Épisode 35 : Étude RECOVERY, volet Dexaméthasone
Dexaméthasone chez les sujets hospitalisés pour la COVID-19 (étude RECOVERY, volet Dexaméthasone)
Diffusé le 28 août 2020
Dans cette 35e baladodiffusion, les Drs Luc Lanthier et Michaël Mayette discutent de l’efficacité de la dexaméthasone dans le traitement des patients hospitalisés pour la COVID-19, en plus de réviser la littérature médicale de juin et juillet 2020.
Référence principale
Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, et al. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021;384(8):693-704. PubMed PMID: 32678530.
Article résumé
Lanthier L, Mayette M, Huard G, Plourde ME, Cauchon M. Chez les sujets hospitalisés pour COVID-19, est-ce que la dexaméthasone diminue la mortalité à 28 jours comparativement au traitement standard ? Rev Med Interne. 2020;41(11):790-91. PubMed PMID: 33077267
Articles associés
Lane HC, Fauci AS. Research in the Context of a Pandemic. N Engl J Med. 2021;384(8):755-757. PubMed PMID : 32678528.
Normand ST. The RECOVERY Platform. N Engl J Med. 2021;384(8):757-758. PubMed PMID : 32706531.
Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. Remdesivir for the Treatment of Covid-19 - Preliminary Report. N Engl J Med. 2020;383(19):1813-26. PubMed PMID : 32445440.
Tang W, Cao Z, Han M, Wang Z, Chen J, Sun W, et al. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial. BMJ. 2020;369:m1849. PubMed PMID : 32409561.
Boulware DR, Pullen MF, Bangdiwala AS, et al. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. N Engl J Med. 2020;383(6):517-525. PubMed PMID : 32492293.
Fosbol EL, Butt JH, Ostergaard L, Andersson C, Selmer C, Kragholm K, et al. Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality. JAMA. 2020;324(2):168-177. PubMed PMID : 32558877.
Shafran DM, Bunce PE, Gold WL. Reducing the risk of infection in a 74-year-old man who is to receive prednisone. CMAJ. 2014;186(16):1239-1240. PubMed PMID : 25024293.
Pericàs JM, Hernandez-Meneses M, Sheahan TP, et al. COVID-19: from epidemiology to treatment. Eur Heart J. 2020;41(22):2092-2112. PubMed PMID: 32511724.
https://www.inesss.qc.ca/covid-19/etudes-cliniques-en-cours-prophylaxie-et-traitement.html
Autres articles d'intérêt récents
Badve SV, Pascoe EM, Tiku A, Boudville N, Brown FG, Cass A, et al. Effects of Allopurinol on the Progression of Chronic Kidney Disease. N Engl J Med. 2020;382(26):2504-13. PubMed PMID : 32579811.
Kim BK, Hong SJ, Cho YH, Yun KH, Kim YH, Suh Y, et al. Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial. JAMA. 2020;323(23):2407-16. PubMed PMID : 32543684.
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, et al. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. N Engl J Med. 2020;383(2):129-40. PubMed PMID : 32640131.
Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, et al. Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. N Engl J Med. 2020;383(3):207-17. PubMed PMID : 32668111.
Guides de pratique récents
FitzGerald JD, Dalbeth N, Mikuls T, Brignardello-Petersen R, Guyatt G, Abeles AM, et al. 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Rheumatol. 2020;72(6):879-95. PubMed PMID : 32390306.
Smolen JS, Landewe RBM, Bijlsma JWJ, Burmester GR, Dougados M, Kerschbaumer A, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis. 2020;79(6):685-99. PubMed PMID : 31969328.
Gossec L, Baraliakos X, Kerschbaumer A, de Wit M, McInnes I, Dougados M, et al. EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update. Ann Rheum Dis. 2020;79(6):700-12. PubMed PMID : 32434812.
Deyell MW, AbdelWahab A, Angaran P, Essebag V, Glover B, Gula LJ, et al. 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society Position Statement on the Management of Ventricular Tachycardia and Fibrillation in Patients With Structural Heart Disease. Can J Cardiol. 2020;36(6):822-36. PubMed PMID : 32536373.
Groulx S, Limburg H, Doull M, Klarenbach S, Singh H, Wilson BJ, et al. Guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease. CMAJ. 2020;192(27):E768-E777. PubMed PMID : 32631908.
Hirani N, Brunner NW, Kapasi A, Chandy G, Rudski L, Paterson I, et al. Canadian Cardiovascular Society/Canadian Thoracic Society Position Statement on Pulmonary Hypertension. Can J Cardiol. 2020;36(7):977-92. PubMed PMID : 32682511.
Ohle R, Yan JW, Yadav K, Cournoyer A, Savage DW, Jetty P, et al. Diagnosing acute aortic syndrome: a Canadian clinical practice guideline. CMAJ. 2020;192(29):E832-E843. PubMed PMID : 32690558.