Pharmacologie
Pharmacologie
Adhesion GPCR ADGRL1/Latrophilin-1 mobilizes β-arrestins as a prerequisite for endosomal restriction of G protein activation and splice-dependent scaffolds
Auteurs et autrices
Sheila Ribalta-Mena, Ana Lilia Moreno-Salinas, Judith Hernández-Aranda, Juana Calderón-Amador, Kerlys Correoso-Braña, Vincent Vialou, Jesús Alberto Olivares-Reyes, Richard Leduc, Antony A Boucard
Using a bioluminescence resonance energy transfer (BRET2) caspase biosensor to study caspase-3 cleavage site specificity
A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function
Auteurs et autrices
Rebecca L. Brouillette, Frédérique Lussier, Émile Breault, Nathan Meneboo, Malihe Hassanzadeh, Victoria Tremblay, Magali Chartier, Élora Midavaine, Laurence Ulrich, Jérôme Côté, Véronique Blais, Christine E. Mona, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Martin Audet, Élie Besserer-Offroy, Philippe Sarret
Unbiased characterization of COVID-19 endotypes leads to prognostication of high-risk individuals using routine blood tests
Auteurs et autrices
William Ma, Antoine Soulé, Catherine Allard, Madeleine Durand, Karine Tremblay, Simon Rousseau, Amin Emad
Pharmacogenetic association study of cannabis use in chronic pain
Auteurs et autrices
William Beauchesne, Jordan Turcotte, Philippe Mercier, Flore Lavoie, Laurence Tessier, Ann-Lorie Gagnon, Catherine Allard, Elliot Fortin, Guillaume Léonard, Louis Gendron, Karine Tremblay
TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection
Auteurs et autrices
Lianne Presley, Jimena Pérez-Vargas, Anaïs Saintigny, Iván Villanueva, Michelle Ho, Jessica Fone, Lara Brinsden, Nidhi Kaushik, Syan Olver, Connor A H Thompson, Diana Bautista-Sánchez, Siobhan Ennis, Mike Chen, Matthew McCallum, Jack T Brown, Sára Ferková, Brian Hetrick, David Veesler, Richard Leduc, Masahiro Niikura, Pierre-Luc Boudreault, Bryce Warner, François Jean
Tunable Biased Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Engineering and Allosteric Site Targeting
Auteurs et autrices
Margot Hadjadj, Malihe Hassanzadeh, Justin Martel, Marie-Frédérique Roy, Hugo Giguère, Alexandre Murza, Brian J Holleran, Yoon Namkung, Ulrike Froehlich, Richard Leduc, Mannix Auger-Messier, Stéphane A Laporte, Pierre-Luc Boudreault