Pharmacologie
Identification of skeletal muscle stem cell adhesion motifs using spot-synthesis-based peptide arrays
Auteurs et autrices
Elizabeth Leblanc, Svenja C Schüler, Yuguo Liu, Léa Théroux, Emmeran Le Moal, Marc-André Bonin, Pierre-Luc Boudreault, C Florian Bentzinger
Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors
Auteurs et autrices
Marie-Edith Nepveu-Traversy, Malihe Hassanzadeh, Laurent Bruneau-Cossette, Élie Besserer-Offroy, Rebecca Brouillette, Sandra Morissette, Hassan Traboulsi, Karyn Kirby, Alexandre Murza, Jean-Michel Longpré, Billy Breton, Fernand-Pierre Gendron, Simon Gaudreau, Pierre-Luc Boudreault, Philippe Sarret
Structure-Guided Optimization of Selective Covalent Reversible Peptidomimetic Inhibitors Targeting TMPRSS6
Auteurs et autrices
Walid Guerrab, Matthieu Lepage, Antoine Désilets, Alexandre Joushomme, Michael Desgagné, Ulrike Froehlich, Richard Leduc, Pierre-Luc Boudreault
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells
Auteurs et autrices
Yuguo Liu, Svenja C Schüler, Simon Dumontier, Frederic Balg, Sonia Bedard, Thibaut Desgeorges, Jerome N Feige, Pierre-Luc Boudreault, C Florian Bentzinger
Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis
Auteurs et autrices
Lounes Haroune, Sabrina Saibi, Jean-Philippe Bellenger, Matthieu Vincenot, Guillaume Léonard, Louis Gendron, Philippe Sarret
Structural characterization of a L-dehydroascorbic acid-L-homocysteine thiolactone reaction product: Intracellular formation in neuronal cells
Auteur et autrices
Ghizlane Loubane, Gabriel Robert, Syed Benazir Firdaus, Raphaël Robidas, Christian Comeau, Pierre-Luc Boudreault, Jeampy E Komba, Hugo Gagnon, J Richard Wagner, Stephen Naylor, Klaus Klarskov
Structural insights into frog skin-derived cyclic peptides as selective matriptase inhibitors
Auteurs et autrices
Agata Gitlin-Domagalska, Malihe Hassanzadeh, Aleksandra Helbik-Maciejewska, Matthieu Lepage, Alexandre Joushomme, Antoine Désilets, Dawid Dębowski, Pierre-Luc Boudreault, Richard Leduc, Krzysztof Rolka
Structure-activity relationships of contulakin-G: Design, synthesis, and characterization of Thr10 analogs for pain modulation
Auteurs et autrices
Annik Lanoie, Sára Ferková, Édouard Caron-Duval, Juliana C C Dallagnol, Sitan Diarra, Alexandre Murza, Alexandre Tremblay, Léa Théroux, Émile Breault, Amirmohammad Ranjbaran, Léa Landry, Jérôme Côté, Jean-Michel Longpré, Pierre-Luc Boudreault, David Chatenet, Philippe Sarret
Aggregation-prone alpha-synuclein proteoforms and dysregulated molecular signatures in the vermiform appendix of synucleinopathy patients
Auteurs et autrices
Ehraz Anis, Saima Zameer, Joshua Wierenga, Peipei Li, Jacek W Sikora, Juozas Gordevicius, Meghan Schilthuis, Richard D LeDuc, Jeffery H Kordower, Michelle Pinho, Sandra Pritzkow, Claudio Soto, Patrik Brundin, Lena Brundin, B A Killinger
Solution NMR Structure and NMR-based Molecular Backbone Dynamics of UbKEKS: A Ubiquitin Variant Encoded in the UBB4 Pseudogene with Emerging Specific and New Functions
Auteurs et autrices
Patrick Delattre, Danny Létourneau, Anna Meller, Xavier Roucou, Francois-Michel Boisvert, Pierre Lavigne
Genetics and response to treatment with metformin for type 2 diabetes
Auteurs et autrices
Laurence Tessier, Sophie St-Amour, Dorianne Simard, Joanie Bouchard, Patrice Perron, Karine Tremblay
Electrochemical and plasmonic detection methods yield comparable analytical performance for DNA hybridization
Auteurs et autrices
Nicolas Fontaine, Arielle Dauphin, Miriam Gaida, Rosalie Simard, Philippe Dauphin-Ducharme
Probing the extent of importin-α targeting of the TAF8 NLS by eliminating its cationic net-charge
Auteurs et autrices
Amirabbas Abdoli, Zhihan Yang, Abdullah Odeh-Ahmed, Olga Bednova, Bruno Lemieux, Leanne Dawe, Aymeric Ravel-Chapuis, Pierre Lavigne, Natalie Zeytuni, Jeffrey V Leyton
Decoding ADGRE5: How Proteolytic Cleavage and Mechanical Forces Unleash Cellular Signals
Auteurs et autrices
Ana L Moreno-Salinas, Arturo Mancini, Samya Aouad, Herthana Kandasamy, Sandra Morissette, Arhamatoulaye Maiga, Michel Bouvier, Richard Leduc, Laurent Sabbagh
Modeling Temporal Summation and Conditioned Pain Modulation in Individuals with and without Chronic Pain
Auteurs
Matthieu Vincenot, Simon Lévesque, Louis Gendron, Félix Camirand Lemyre, Serge Marchand, Guillaume Léonard
ArfGAP with Dual Pleckstrin Homology Domains 2 Promotes Hypertrophy of Cultured Neonatal Cardiomyocytes
Auteurs et autrices
Jonathan Berthiaume, Audrey-Ann Dumont, Lauralyne Dumont, Marie-Frédérique Roy, Hugo Giguère, Mannix Auger-Messier
Optimization of the prostaglandin F2α receptor for structural biology
Auteurs et autrices
Marine Salze, Sébastien Chrétien, Tegvir S Boora, Madalina Macovei, Eric Barbeau, Véronique Blais, Stéphane A Laporte, Martin Audet
Glucagon-like peptide-1 is involved in fasting and postprandial blood flow regulation of subcutaneous adipose tissue
Auteurs et autrices
Richard Sotorník, Pascal Brassard, Julie Ménard, Maude Gagnon-Auger, Jean-Patrice Baillargeon, Jean-Luc Ardilouze
Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice
Auteurs et autrices
Cornelis Immanuel van der Zouwen, Andrea Juárez Tello, Jacinthlyn Sylvia Suresh, Juan Duque-Yate, Ted Hsu, Vaibhav Konanur, Joël Boutin, Mitchell F Roitman, Dimitri Ryczko
Role of Electrode Microstructuration in Electrochemical Aptamer-Based Biosensors for Localized Measurements
Contribution of peripheral and central delta opioid receptors in the relief of migraine-like headache in female and male rats
Auteurs et autrices
Manon Dussol, Gisela da Silva Borges, Claudie Beaulieu, Hadir Ghorbel, Amélie Descheemaeker, Karine Herault, Daniel Voisin, Philippe Luccarini, Louis Gendron, Radhouane Dallel
Association of the TNFRSF1B-rs1061622 variant with nonresponse to infliximab in ulcerative colitis
Auteurs et autrices
Laurence Tessier, Ann-Lorie Gagnon, Sophie St-Amour, Mathilde Côté, Catherine Allard, Mathieu Durand, Danny Bergeron, Alexandre Lavoie, Alban Michaud-Herbst, Karine Tremblay
Structural basis of TMPRSS11D specificity and autocleavage activation
Auteurs et autrices
Bryan J. Fraser, Ryan P. Wilson, Sára Ferková, Olzhas Ilyassov, Jackie Lac, Aiping Dong, Yen-Yen Li, Alma Seitova, Yanjun Li, Zahra Hejazi, Tristan M. G. Kenney, Linda Z. Penn, Aled Edwards, Richard Leduc, Pierre-Luc Boudreault, Gregg B. Morin, François Bénard et Cheryl H. Arrowsmith
Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood
Auteurs et autrices
Laurence Vincent, Catherine Lapointe, Patrick P McDonald, Christos Rammos, Tienush Rassaf, Maria Köllnberger, Hanna Tinel, Stefan Heitmeier, Pedro D'Orléans-Juste
Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail
Auteurs et autrices
Émile Breault, Rebecca L Brouillette, Terence E Hébert, Philippe Sarret, Élie Besserer-Offroy
From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants
Auteurs et autrices
Gabriel Lemieux, Jimena Pérez-Vargas, Antoine Désilets, Malihe Hassanzadeh, Connor A H Thompson, Alice Gravel-Trudeau, Alexandre Joushomme, Siobhan Ennis, Ivan Villanueva, Étienne Marouseau, Bryan J Fraser, William Champagne, Matthieu Lepage, Masahiro Niikura, Cheryl H Arrowsmith, François Jean, Richard Leduc, Pierre-Luc Boudreault
A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome
Auteurs et autrices
Juan Antonio Contreras Vite, Alexandria Tiffinger, Léa Théroux, Nathalie Morin, Mannix Auger-Messier, Pierre-Luc Boudreault, Philippe Sarret, Olivier Lesur, Robert Dumaine
Endothelial SHP-1 regulates diabetes-induced abnormal collateral vessel formation and endothelial cell senescence
Auteurs et autrices
Alexandre Nadeau, Marike Ouellet, Raphaël Béland, Clément Mercier, Stéphanie Robillard, Farah Lizotte, Marc-Antoine Despatis, C Florian Bentzinger, Pedro Geraldes
Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency
Auteurs et autrices
Alexandre Joushomme, Antoine Désilets, William Champagne, Malihe Hassanzadeh, Gabriel Lemieux, Alice Gravel-Trudeau, Matthieu Lepage, Sabrina Lafrenière, Ulrike Froehlich, Karin List, Pierre-Luc Boudreault, Richard Leduc
PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes
Auteurs et autrices
Sophie St-Amour, Laurence Tessier, Janie Harnois, Catherine Allard, Alexandre Lavoie, Philippe Caron, Luigi Bouchard, Patrice Perron, Karine Tremblay
Pain experience of children with Christianson syndrome
Auteurs et autrices
Shajenth Premachandran, Don Daniel Ocay, Claudie Beaulieu, Jonathan Balduzzi, Diana-Luk Ye, Albena Davidova, Rakan Bokhari, Jean A Ouellet, John Orlowski, Louis Gendron, Reza Sharif-Naeini, Catherine E Ferland
Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord
Auteurs et autrices
Alessandro Pazzaglia, Andrej Bicanski, Andrea Ferrario, Jonathan Arreguit, Dimitri Ryczko, Auke Ijspeert
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor
Auteurs et autrices
Rebecca L Brouillette, Christine E Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret
Evaluation of the implementation in primary care of genetic testing for the screening of MODY2 (iMOgene): protocol for an implementation pilot study
Auteurs et autrices
Samuel Legeay, Marie-Eve Poitras, Vanessa Tremblay-Vaillancourt, Amélie Fournier, Luigi Bouchard, Josianne Leblanc, Philippe Caron, Catherine Savard, Nathalie Bettez, Karine Tremblay
Simple A-D2-A Nonfullerene Acceptors for Efficient Binary Bulk Heterojunction Organic Solar Cells
Auteurs et autrices
Andrii Byrka, Léo Boivin, Élodie V d'Astous, Rahul Singhal, Paul-Ludovic Karsenti, Philippe Dauphin-Ducharme, Bernhard Witulski, Ganesh D Sharma, Pierre D Harvey