Pharmacologie
Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail
Auteurs et autrices
Émile Breault, Rebecca L Brouillette, Terence E Hébert, Philippe Sarret, Élie Besserer-Offroy
From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants
Auteurs et autrices
Gabriel Lemieux, Jimena Pérez-Vargas, Antoine Désilets, Malihe Hassanzadeh, Connor A H Thompson, Alice Gravel-Trudeau, Alexandre Joushomme, Siobhan Ennis, Ivan Villanueva, Étienne Marouseau, Bryan J Fraser, William Champagne, Matthieu Lepage, Masahiro Niikura, Cheryl H Arrowsmith, François Jean, Richard Leduc, Pierre-Luc Boudreault
A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome
Auteurs et autrices
Juan Antonio Contreras Vite, Alexandria Tiffinger, Léa Théroux, Nathalie Morin, Mannix Auger-Messier, Pierre-Luc Boudreault, Philippe Sarret, Olivier Lesur, Robert Dumaine
Endothelial SHP-1 regulates diabetes-induced abnormal collateral vessel formation and endothelial cell senescence
Auteurs et autrices
Alexandre Nadeau, Marike Ouellet, Raphaël Béland, Clément Mercier, Stéphanie Robillard, Farah Lizotte, Marc-Antoine Despatis, C Florian Bentzinger, Pedro Geraldes
Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency
Auteurs et autrices
Alexandre Joushomme, Antoine Désilets, William Champagne, Malihe Hassanzadeh, Gabriel Lemieux, Alice Gravel-Trudeau, Matthieu Lepage, Sabrina Lafrenière, Ulrike Froehlich, Karin List, Pierre-Luc Boudreault, Richard Leduc
PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes
Auteurs et autrices
Sophie St-Amour, Laurence Tessier, Janie Harnois, Catherine Allard, Alexandre Lavoie, Philippe Caron, Luigi Bouchard, Patrice Perron, Karine Tremblay
Pain experience of children with Christianson syndrome
Auteurs et autrices
Shajenth Premachandran, Don Daniel Ocay, Claudie Beaulieu, Jonathan Balduzzi, Diana-Luk Ye, Albena Davidova, Rakan Bokhari, Jean A Ouellet, John Orlowski, Louis Gendron, Reza Sharif-Naeini, Catherine E Ferland
Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord
Auteurs et autrices
Alessandro Pazzaglia, Andrej Bicanski, Andrea Ferrario, Jonathan Arreguit, Dimitri Ryczko, Auke Ijspeert
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor
Auteurs et autrices
Rebecca L Brouillette, Christine E Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret
Evaluation of the implementation in primary care of genetic testing for the screening of MODY2 (iMOgene): protocol for an implementation pilot study
Auteurs et autrices
Samuel Legeay, Marie-Eve Poitras, Vanessa Tremblay-Vaillancourt, Amélie Fournier, Luigi Bouchard, Josianne Leblanc, Philippe Caron, Catherine Savard, Nathalie Bettez, Karine Tremblay
Simple A-D2-A Nonfullerene Acceptors for Efficient Binary Bulk Heterojunction Organic Solar Cells
Auteurs et autrices
Andrii Byrka, Léo Boivin, Élodie V d'Astous, Rahul Singhal, Paul-Ludovic Karsenti, Philippe Dauphin-Ducharme, Bernhard Witulski, Ganesh D Sharma, Pierre D Harvey