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Darel Hunting

Professeur, Faculté de médecine et des sciences de la santé
FMSS Dép. médecine nucléaire et radiobiologie

Présentation

Sujet de recherche

Apoptose et cancer, Carcinogenèse, Dépistage génétique des maladies, Oncogènes, Gène suppresseur

Disciplines de recherche

Biochimie, Biologie moléculaire

Mots-clés

Apoptosis, Cancer, Cell cycle, DNA damage, DNA repair, p21Waf1/Cip1, p53, poly(ADP-ribose), Radiation, Radiosensibilisation

Intérêts de recherche

Développement de radiosensibilisateurs. Mécanismes de radiosensibilisation de l'ADN par des dérivés halogénés. Dommage à l'ADN par les électrons secondaires. Mécanismes de réparation de l'ADN. Formation des ponts interbrins dans l'ADN par les rayonnements ionisants.

Centre de recherche

Aucun

Langues parlées et écrites

Anglais, Français

Diplômes

(1985). (Postdoctorat, Stage post-doctoral). University of Texas at Dallas.

(1984). (Postdoctorat, Stage post-doctoral). University of Alberta.

(1982). (Postdoctorat, Stage post-doctoral). Washington University Medical School.

(1981). (Doctorat, Doctorat). University of Alberta.

(1975). (Baccalauréat, B.Sc.). Bishop's University.

Prix et distinctions

  • Certificate of Merit Award/Certificat de mérite. CAME/ACEM. (Distinction).

Financement

  • Subvention. (Terminé). Chercheur principal. Intégration de technologies avancées dans un complexe de recherche biomédicale multidisciplinaire.. Université de Sherbrooke. Parc mobilier. 7 858 $. (2006-2013)

Publications

Articles de revue

  • Brodeur N , Cloutier P , Bass AD , Bertrand G , Hunting DJ , Grandbois M , Sanche L. (2018). Absolute cross section for DNA damage induced by low-energy (10 eV) electrons: Experimental refinements and sample characterization by AFM. The Journal of chemical physics 149 (16), 164904. (Article publié).
  • Degroote S , Hunting D , Takser L. (2018). Periconceptional folate deficiency leads to autism-like traits in Wistar rat offspring. Neurotoxicology and teratology 66 132-138. (Article publié).
  • Brunet MA , Levesque SA , Hunting DJ , Cohen AA , Roucou X. (2018). Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship. Genome research 28 (5), 609-624. (Article publié).
  • Shao, Yu; Dong, Yanfang; Hunting, Darel; Zheng, Yi; Sanche, Leon. (2017). A Unified Mechanism for the Generation of Isolated and Clustered DNA Damages by a Single Low Energy (5-10 eV) Electron. Journal of Physical Chemistry C. 121 (4), 2466-2472. (Article publié).
  • Samandi S , Roy AV , Delcourt V , Lucier JF , Gagnon J , Beaudoin MC , Vanderperre B , Breton MA , Motard J , Jacques JF , Brunelle M , Gagnon-Arsenault I , Fournier I , Ouangraoua A , Hunting DJ , Cohen AA , Landry CR , Scott MS , Roucou X. (2017). Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins. eLife 6 . (Article publié).
  • Degroote, Stéphanie, Hunting, Darel, Takser, Larissa. (2017). Improved assessment of sensorimotor gating in animal models relevant to ASD: A data modelling approach to quantify PrePulse Inhibition of the acoustic startle reflex. Journal of Neuroscience Methods 276 13-22. DOI. (Article publié).
  • Tsvetan G Gantchev, Peicho St. Petkov, Darel J. Hunting. (2017). cisConformational rearrangements of 1,2-d(GG) intrastrand -diammineplatinum crosslinked DNA is driven by counter-ion penetration within the minor groove of the modified site. Journal of Molecular Modeling . (.), . (Article accepté).
  • Roucou X., Samandi S., Roy A., Delcourt V., Lucier JF., Gagnon J., Beaudoin M., Vanderperre B., Breton MA, Motard J., Jacques JF., Gagnon-Arsenault I., Fournier I., Ouangraoua A., Hunting DJ, Cohen A., Landry C., Scott M. (2016). Deep transcriptome annotation suggests cooperation between small and large proteins coded by thesame genes. eLife (Révisions requises).
  • Stephanie Degroote, Darel Hunting,Larissa Takser. (2016). Improved assessment of sensorimotor gating inanimal models relevant to ASD: A data modelling approach to quantify PrePulseInhibition of the acoustic startle reflex. Journal of Neuroscience Methods 276 13-22. DOI. (Article publié).
  • Degroote S, Hunting DJ, Baccarelli AA, Takser L. (2016). Maternal gut and fetal brain connection: Increased anxiety and reducedsocial interactions in Wistar rat offspring following peri-conceptionalantibiotic exposure. Prog Neuropsychopharmacol Biol Psychiatry 71 76-82. (Article publié).
  • Gillet V, Hunting DJ, Takser L. (2016). Turing Revisited:Decoding the microRNA Messages in Brain Extracellular Vesicles for EarlyDetection of Neurodevelopmental Disorders. Curr Environ Health Rep 3 (3), 188-201. (Article publié).
  • S. Kouass Sahbani, P. Cloutier, A. D. Bass, D. J. Hunting, & L. Sanche. (2015). Electron Resonance Decayinto a Biological Function: Decrease in Viability of E. coli Transformed byPlasmid DNA Irradiated with 0.5?18 eV Electrons. Journal of Physical Chemistry Letters 6 3911?3914. (Article publié).
  • S. Kouass Sahbani, L. Sanche, P. Cloutier, A. Bass & D.J. Hunting. (2015). Loss of cellulartransformation efficiency induced by DNA irradiation with low-energy (10 eV)electrons. The Journal of Physical Chemistry B 118 (46), 13123-13131. (Article publié).
  • B. Behmand, J.-L. Marignier, M. Mostafavi, J. R. Wagner, D. J. Hunting & L. Sanche. (2015). Radiosentization of DNAby Cisplatin Adducts Results from an Increase in the Rate Constant for theReaction with Hydrated Electrons and Formation of PtI. Journal of Physical Chemistry B 119 (30), 9496-9500. (Article publié).
  • O. Boulanouar, M. Rezaee, M. Fromm, P. Cloutier, Y. Zheng, A.D. Bass, M. Michaud, D.J. Hunting & L. Sanche. (2014). Absolute measurement of low energy electron-induced strand-break damage in films of plasmid DNA andplasmid DNA/Dap2+ complexes. Journal of Physics: Conference Series 488 1. (Article publié).
  • Rezaee M, Alizadeh E, Cloutier P, Hunting DJ, Sanche L. (2014). A single subexcitation-energy electron can induce a double-strand break in DNA modified by platinum chemotherapeutic drugs. ChemMedChem 9 (6), 1145-9.
  • Degroote S, Hunting DJ, Sébire G, Takser L. (2014). Autistic-like traits in Lewis rats exposed perinatally to a mixture of common endocrine disruptors. Endocrine Disruptors 2 (1), (Article publié).
  • B. Behmand, J.R. Wagner, L. Sanche & D.J. Hunting. (2014). Cisplatin IntrastrandAdducts Sentitize DNA to Base Damage by Hydrated Electrons. The Journal of Physical Chemistry B. 118 4803-4808. (Article publié).
  • Rezaee M, Hunting DJ, Sanche L. (2014). Correlation between energy deposition and molecular damage from Auger electrons: A case study of ultra-low energy (5-18 eV) electron interactions with DNA. Med Phys. 41 (7), 07250.
  • Kouass Sahbani S, Rezaee M, Cloutier P, Sanche L, Hunting DJ. (2014). Non-DSB clustered DNA lesions induced by ionizing radiation are largely responsible for the loss of plasmid DNA functionality in the presence of cisplatin. Chem Biol Interact. 217 9-18.
  • S. Sahbani, S. Girouard, P. Cloutier, D.J. Hunting & L. Sanche. (2014). The relative contributions of DNA strand breaks, base damage and clustered lesions to theloss of DNA functionality induced by ionizing radiation. Radiation research 181 99-110. (Article publié).
  • M. Rezaee, E. Alizadeh, P. Cloutier, D.J. Hunting & L. Sanche. (2013). A single subexcitation-energy electron can induce a double strand break in DNA modified by platinum chemotherapeutic drugs. Angewandte Chemie International Edition Journal 9 ((6)), 1145-9. (Article soumis).
  • Rezaee M,* Sanche L, Hunting DJ. (2013). Cisplatin enhances the formation of DNA single- and double-strand breaks by hydrated electrons and hydroxyl radicals. Radiation research 179 (3), 323-31.
  • Huang C, Bao Q, Hunting D, Zheng Y, Sanche L. (2013). Conformation-dependent DNA damage induced by gold nanoparticles. Journal of biomedical nanotechnology 9 5.
  • B. Behmand, P. Cloutier, S. Girouard, J.R. Wagner, L. Sanche, D.J. Hunting. (2013). Hydrated Electrons React with High Specificity with Cisplatin Bound to Single Stranded DNA. The Journal of Physical Chemistry 117 (50), 15994-9. (Article accepté).
  • M.-E. Dextraze, J.R. Wagner and D.J. Hunting. (2013). Mapping interstrand cross-links induced by gamma and UV radiation in bromodeoxyuridine-substituted DNA. Nucleic Acids Research (Article soumis).
  • Rezaee M , Hunting DJ , Sanche L. (2013). New Insights into the Mechanism Underlying the Synergistic Action of Ionizing Radiation With Platinum Chemotherapeutic Drugs: The Role of Low-Energy Electrons. International journal of radiation oncology, biology, physics 87 (4), 847-53.
  • S. Sahbani, S. Girouard, P. Cloutier, D.J. Hunting & L. Sanche. (2013). The relative contributions of DNA strand breaks, base damage and clustered lesions to the loss of DNA functionality induced by ionizing radiation. Radiation Research N/A (N/A), N/A. (Article sous presse).
  • Rezaee M,* Cloutier P, Bass AD, Michaud M, Hunting DJ, Sanche L. (2012). Absolute cross section for low-energy-electron damage to condensed macromolecules: a case study of DNA. Physical review. E, Statistical, nonlinear, and soft matter physics 86 (3 Pt 1), 031913.
  • Rezaee M , Alizadeh E , Hunting D , Sanche L. (2012). DNA-Platinum Thin Films for Use in Chemoradiation Therapy Studies. Bioinorganic chemistry and applications 2012 9.
  • Smith K, Malatesti N, Cauchon N, Hunting D, Lecomte R, van Lier JE, Greenman J, Boyle RW. (2011). Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action. Immunology 132 (2), 256-65.
  • Xiao F, Zheng Y, Cloutier P, He Y, Hunting D, Sanche L. (2011). On the role of low-energy electrons in the radiosensitization of DNA by gold nanoparticles. Nanotechnology 22 (46), 465101.
  • Alizadeh E, Cloutier P, Hunting D, Sanche L. (2011). Soft X-ray and low energy electron-induced damage to DNA under N2 and O2 atmospheres. The journal of physical chemistry. B 115 (15), 4523-31.
  • Dextraze ME,* Gantchev T, Girouard S, Hunting D. (2010). DNA interstrand cross-links induced by ionizing radiation: an unsung lesion. Mutation research 704 (1-3), 101-7.
  • Gantchev TG, Hunting DJ. (2010). Modeling the interactions of the nucleotide excision repair UvrA(2) dimer with DNA. Biochemistry 49 (51), 10912-24.
  • Hébert EM,* Debouttière PJ, Lepage M, Sanche L, Hunting DJ. (2010). Preferential tumour accumulation of gold nanoparticles, visualised by Magnetic Resonance Imaging: radiosensitisation studies in vivo and in vitro. International journal of radiation biology 86 (8), 692-700.
  • Dumont A,* Zheng Y, Hunting D, Sanche L. (2010). Protection by organic ions against DNA damage induced by low energy electrons. The Journal of chemical physics 132 (4), 045102.

Chapitres de livre

  • T.G. Gantchev, M.-E. Dextraze, D.J. Hunting. (2011). DNA radiosensitization: The search for repair refractive lesions including double strand breaks and interstrand crosslinks. Clark C. Chen. Selected Topics in DNA Repair (1, 2, 417-434). États-Unis : Clark Chen. (Article publié).

Autres contributions

Présentations

  • B. Behmand, A. Noronha, C.J. Wilds, J.L. Marignier, M. Mostafavi, D.J. Hunting and L. Sanche. (2017). Cisplatin Adducts Sensitize double-stranded DNA to Attack by Hydrated Electrons Leading to Interstrand Crosslink Formation. 30th Miller Conference on Radiation Chemistry. Castellammare del Golfo, Sicile, Italie
  • N. Brodeur, D.J. Hunting, L. Sanche. (2017). Improvements on the cross section measurements for DNA damage induced bylow energy electrons. 63rd Annual Meeting of the Radiation Research Society. Cancun, Mexique
  • N. Brodeur, P. Cloutier, A. Bass, D. Hunting & L. Sanche. (2016). Approche expérimentale pour une meilleure compréhension des dommages à l’ADN en radiothérapie: Le rôle des électrons de basse énergie. Association Canadienne Française pour l’Avancement des Sciences (ACFAS). Montréal, Canada
  • Kouass Sahbani, P. Cloutier, A.D. Bass, D.J. Hunting, and L. Sanche. (2016). Effect of Gamma radiation and low energy electrons on DNA functionality. International workshop on Damage to DNA. Melbourne, Australie
  • S. Kouass-Sahbani, P. Cloutier, A.D. Bass, D.J. Hunting, and L. Sanche. (2016). Effect of low energy (0.5? 18 eV) electrons in the viability of e.coli transformed by plasmid DNA. 62nd Annual Meeting of the Radiation Research Society. Waikoloa, États-Unis
  • T. Thippayamontri, M. Shi, D. Hunting, B.Paquette and L. Sanche. (2016). Radiosensitizing effect of PVA coated goldnanoparticles: Study in the Fricke dosimeter and plasmid DNA damage. Nuclear Science and Technology Conference (INST2016). Bangkok, Thaïlande
  • M. Rezaee, D.J. Hunting & L. Sanche. (2015). Sensitization of DNA to ionizing Radiation by platinum chemotherapeutic drugs. World Congress on Medical Physics and Biomedical Engineering. Toronto, Canada
  • E. Alizadeh, M. Rezaee, D.J. Hunting & L. Sanche. (2015). Synergistic action of ionizing radiation with platinum-based chemotherapeutic drugs: Soft X-rays and low-energy electrons. World Congress on Medical Physics and Biomedical Engineering. Toronto, Canada
  • B. Behmand, P. Cloutier, R. Wagner, L. Sanche, D. Hunting, J.L. Marignier, & M. Mostafavi. (2014). A model comparing the clinical application of a variable relative biological effectiveness based on high resolution in vitro studies. 60th Radiation Research Society Annual Meeting. Las Vegas, États-Unis
  • S.Degroote, G.Sébire, L. Takser. (2014). Autistic-like traits in Lewis rats exposed perinatally to a mixture of common endocrine disruptors. Gordon Research Conference. Barga, Italie
  • B. Behmand, P. Cloutier, R. Wagner, L. Sanche, D. Hunting, J.L. Marignier & M. Mostafavi. (2014). Cisplatin Adducts Sensitive DNA to Attack by Hydrated Electrons Leading to Cisplatin Detachment and Base Damage. 60th Radiation Research Society Annual Meeting. Las Vegas, États-Unis
  • B. Behmand, D. Hunting & L. Sanche. (2014). Cisplatin Adducts Sensitize DNA to Attack by hydrated Electrons Leading to Cisplatin Detachment and Base Damage. Gordon Research Conference on Radiation Chemistry, Proctor Academy. Andover, États-Unis
  • S.K. Sahbani, P. Cloutier, A. Bass, D. Hunting & L. Sanche. (2014). Les dommages aux bases et les dommages multiples localisés de l'ADN double-brins peuvent être induits par les électrons de basse énergie. 25ème Forum des Sciences Biologiques et Biotechnologie. Hammamet, Tunisie
  • S.K. Sahbani, P. Cloutier, A. Bass, L. Sanche & D. J. Hunting. (2014). Low energy electron induced lethal lesions in DNA as measured by the loss of plasmid functionality. Gordon Research Conference on Radiation Chemistry, Proctor Academy. Andover, États-Unis
  • S.K. Sahbani, P. Cloutier, A. Bass, L. Sanche & D. Hunting. (2014). Low energy electrons induce loss of plasmid functionality by producing lethal lesions in DNA. 60th Annual International Meeting, Radiation Research Society. Las Vegas, États-Unis
  • S. Sahbani, D. Hunting & L. Sanche. (2014). Quantification de bases endommagées et de dommage multiples localisés de l'ADN double-brins induits par des électrons de basse énergie. 82e Congrès de l'ACFAS, Université Concordia. Montréal, Canada
  • M. Rezaee, M. Michaud, D. J. Hunting & L. Sanche. (2014). Radiobiological Effects and Nanodosimetry of Auger Electrons: A case study 5-18 eV Electron Interactions with DNA. 13th International Workshop on Radiation. Boston, États-Unis
  • B. Behmand, P. Cloutier, S. Girouard, J.R. Wagner, D. Hunting, J.-L. Marignier, M. Mostafavi & L. Sanche. (2014). Radiosensibilisation du dommage induit par les électrons hydratés aux bases de l'ADN par le cisplatine et son détachement. 17e Journées d'Études de la chimie sous Rayonnement. Fréjus, Var, France
  • O. Boulanouar, M. Rezaee, M. Fromm, P. Cloutier, Y. Zheng, A. D. Bass, M. Michaud, D. J. Hunting & L. Sanche. (2013). Absolute measurement of low energy electron-induced strand-break damage in films of plasmid DNA and plasmid DNA/Dap2+ complexes. XXVIII International Conference on Photonic, Electronic and Atomic Collisions. Lanzhou, Chine
  • M. Rezaee, D. Hunting & L. Sanche. (2013). Carboplatin is more efficient than cisplatin in sensitizing DNA to direct effects of ionizing radiation. 59th Radiation Research Society Annual Meeting. New Orleans, États-Unis
  • S. Kouass Sahbani, M. Rezaee, P. Cloutier, L. Sanche & D.J. Hunting. (2013). Cisplatin enhances the formation of DNA damage and the loss of functionality induced by ionizing radiation. 59th Radiation Research Society Annual Meeting. New Orleans, États-Unis
  • X. Yao, S. Chen, Y. Chen, S. Sahbani, D. Hunting, Y. Zheng & L. Sanche. (2013). DNA damage Induced by gold nanoparticles is Conformation-dependent. 40th Annual Meeting of the European Radiation Research Society. Dublin, Irlande
  • E. Alizadeh, M. Rezaee, D. J. Hunting & L. Sanche. (2013). Damage induced by low energy electrons and soft X-rays to DNA modified by platinum chemotherapeutic drugs. 2nd Nano-Ion Beam Cancer Therapy. Sopot, Pologne
  • B. Behmand, S. Girouard, P. Cloutier, R. Wagner, D. Hunting & L. Sanche. (2013). Dommages au complexe cisplatine-ADN induits par des électrons hydratés. 81e Congrès de l'ACFAS. Québec, Canada
  • M. Rezaee, S. Kouass Sahbani, D. J. Hunting & L. Sanche. (2013). Hydrated Electrons Induce both DNA Single and Double Strand Breaks in the Presence of Cisplatin. 40th Annual Meeting of the European Radiation Research Society. Dublin, Irlande
  • S. Kouass Sahbani, P. Cloutier, S. Girouard, L. Sanche & D. Hunting. (2013). Les cassures doubles brins ne sont pas les lésions létales les plus fréquentes induites par les effets indirects du rayonnement ionisant. 81e Congrès de l'ACFAS. Québec, Canada
  • E. Alizadeh, M. Rezaee, D. J. Hunting & L. Sanche. (2013). Platinum chemotherapeutic drugs sensitize DNA towards sub-excitation-energy electrons to induce cluster lesions. 59th Radiation Research Society Annual Meeting. New Orleans, États-Unis
  • S. Kouass Sahbani, M. Rezaee, P. Cloutier, L. Sanche & D.J. Hunting. (2013). Radiosensitization of plasmid DNA by cisplatin: enhancement in damage and loss of functionality. 40th Annual Meeting of the European Radiation Research Society. Dublin, Irlande
  • M. Rezaee, E. Alizadeh, D.J. Hunting & L. Sanche. (2013). The role of dissociative electron attachment in the formation of strand breaks in DNA modified by platinum chemotherapeutic drugs. 2nd Nano-Ion Beam Cancer Therapy. Sopot, Pologne
  • M. Rezaee, D.J. Hunting & L. Sanche. (2012). Double strand breaks are not the most frequent lethal lesion created by the indirect effect of ionizing radiation. Gordon Research Conference on radiation chemistry. Andover, États-Unis
  • M. Rezaee, D. Hunting & L. Sanche. (2012). Effect of platinum chemotherapeutic drugs on DNA cluster damage induced by low energy electrons. 12th International Workshop on Radiation Damage to DNA. Prague, Tchèque, République
  • S. Kouass Sahbani, P. Cloutier, L. Sanche & D. Hunting. (2012). Les cassures doubles brins ne sont pas les lésions létales les plus fréquentes induites par les effets indirects du rayonnement ionisant. 16èmes Journées d’Études de la Chimie sous Rayonnement (JECR 2012). Sines, Portugal
  • M. Rezaee, P. Cloutier, A.D. Bass, M. Michaud, D.J. Hunting & L. Sanche. (2012). Quasi-absolute cross section for DNA damage induced by low energy electrons. Quantum scattering calculations and Monte Carlo simulations to model dynamical processes in biosystems. Madrid, Espagne
  • M. Rezaee, P. Cloutier, A.D. Bass, D.J. Hunting & L. Sanche. (2012). Quasi-absolute cross section for low energy electron damage to condensed macromolecules: a case study of DNA. 4th Focused Electron Beam Induced Processing Workshop. Zaragova, Espagne
  • (2011). Damage induced by hydrated electrons to the cisplatin-DNA complex. 14th International Congress of Radiation Research. Varsovie, Pologne
  • B. Behmand, P. Cloutier, S. Girouard, A. Bass, D. Hunting, L. Sanche. (2011). Dommages au complexe cisplatine-ADN induits par des électrons de basse énergie et par des électrons hydratés. 79e Congrès de l'ACFAS, Université Bishop. Sherbrooke, Canada
  • E. Alizadeh, P. Cloutier, D. Hunting, L. Sanche. (2011). Dommages à l'ADN maintenu sous atmosphère d’azote ou d’oxygène, induits par des rayons-X et des électrons de basses énerg. 79e Congrès de l'ACFAS, Université Bishop. Sherbrooke, Canada
  • L. Sanche. (2011). How can we exploit the properties of low energy and hydrated electrons to improve radiotherapy?. 14th International Congress of Radiation Research. Varsovie, Pologne
  • E. Alizadeh, D. Hunting & L. Sanche. (2011). Induction of Strand Breaks in DNA by Low Energy Electrons and Soft X-rays under Nitrous Oxide Atmosphere. 14th International Congress of Radiation Research. Warsaw, Pologne
  • M. Rezaee, E. Alizadeh, D. Hunting & L. Sanche. (2011). Optimized Method for Preparation of Nanoscale DNA-Platinum Films for Use in Chemoradiation Therapy Studies. Proceedings of the 2nd International Conference on Nanotechnology: Fundamentals and Applications. Ottawa, Canada
  • M. Rezaee, P. Cloutier, D.J. Hunting & L. Sanche. (2011). Radiosensitization of DNA to low energy electron by carboplatin and cisplatin. 14th International Congress of Radiation Research. Varsovie, Pologne
  • L. Sanche. (2010). DNA damage by low energy electrons: What we have learned and what we wish to know. Gordon Research Conferences. Andover, États-Unis