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Claude Spino

Professeur, Faculté des sciences
FAC. SCIENCES Chimie

Présentation

Sujet de recherche

Chemical Synthesis and Catalysis, Organic Molecules and Biomolecules, Inorganic and Organometallic Compounds

Disciplines de recherche

Chemistry

Mots-clés

Natural Products, Organic Synthesis, Pharmaceuticals, Reaction Mechanism, Synthetic Methodology

Intérêts de recherche

My main research interest is the discovery of new synthetic pathways to bioactive molecules. Other interests range from the design of new reactions to the solution of reaction mechanisms.

Centre de recherche

None

Langues parlées et écrites

Anglais, Français

Diplômes

(1988). (Doctorate, Doctorate in Organic Chemistry). University of British Columbia.

(1983). (Bachelor's, Bachelor in Chemistry). Université de Montréal.

Prix et distinctions

  • (2012) Visiting Professor at Australian National University. Australian National University. (Distinction).
  • (2009) Prix Marcel-Bastin. Université de Sherbrooke. (Distinction).
  • (2009) Best chemistry professor. Université de Sherbrooke. (Distinction).
  • (2009) Visiting professor at Univesité de Rennes 1. Université de Rennes I. (Distinction).
  • (2008) Canadian Academic Development Program Research Award. (Prize / Award).
  • (1997) Boehringer-Ingelheim Young Investigator Award. (Prize / Award).
  • Best biochemistry professor. Université de Sherbrooke. (Distinction).

Publications

Articles de revue

  • Martin Déry, Kevin Assouvie, Nora Heinrich, Isabelle Rajotte, Louis-Philippe D. Lefebvre, Marc-André Legault, and Claude Spino. (2015). N‑Heterocycles from Chromium Aminocarbenes. Organic Letters 17 (5), 1312-1315. (Published).
  • Martin Déry, Louis-Philippe D.Lefebvre, Kevin Aissa, and Claude Spino. (2013). N-Heteropolycyclic compounds from the formal intramolecular (4+1)-cycloaddition of chromium aminocarbenes. Organic Letters (In Press).
  • Simon Pichette, Dana Winter, Jean Lessard, and Claude Spino. (2013). Transforming cycloalkanone into N-heterocycles: Formal Total Synthesis of (-)-gephyrotoxin C. Journal of Organic Chemistry (Revision Requested).
  • Patrice Arpin, Bryan Hill, Robin Larouche-Gauthier, and Claude Spino. (2013). Prins cyclization of a-bromoethers under basic conditions. Canadian Journal of Chemistry 91 (12), 1193-1201. (Published).
  • Pichette S , Aubert-Nicol S , Lessard J , Spino C. (2012). Photochemical and thermal ring-contraction of cyclic hydroxamic acid derivatives. The Journal of organic chemistry 77 (24),
  • Beaumier F , Dupuis M , Spino C , Legault CY. (2012). Formal intramolecular (4 + 1)-cycloaddition of dialkoxycarbenes: control of the stereoselectivity and a mechanistic portrait. Journal of the American Chemical Society 134 (13),
  • Laflamme P , Beaudoin A , Chapaton T , Spino C , Soldera A. (2012). Simulated infrared spectra of triflic acid during proton dissociation. Journal of computational chemistry 33 (1190-1196),
  • Laflamme, Patrick; Beaudoin, Alexandre; Chapaton, Thomas; Spino, Claude; Soldera, Armand. (2012). Molecular modeling assisted design of new monomers utilized in fuel cell proton exchange membranes. Journal of Membrane Science 401-402 (56-60),
  • Spino C. (2011). Menthone and p-menthyl-3-carboxaldehyde as chiral auxiliaries. Chemical communications (Cambridge, England) 47 (17),
  • Drouin A , Winter DK , Pichette S , Aubert-Nicol S , Lessard J , Spino C. (2011). Photochemical rearrangement of N-mesyloxylactams: stereospecific formation of N-heterocycles. The Journal of organic chemistry 76 (1),
  • Winter DK , Drouin A , Lessard J , Spino C. (2010). Photochemical rearrangement of N-chlorolactams: a route to N-heterocycles through concerted ring contraction. The Journal of organic chemistry 75 (8),
  • Gagnon D , Spino C. (2009). Stereoselective synthesis of (+)-aspidofractinine. The Journal of organic chemistry 74 (16),
  • Arbour M , Roy S , Godbout C , Spino C. (2009). Stereoselective synthesis of (+)-euphococcinine and (-)-adaline. The Journal of organic chemistry 74 (10),
  • Perreault S , Poirier M , Léveillé P , René O , Joly P , Dory Y , Spino C. (2008). Mechanism and regioselectivity of the cycloaddition of thiones derived from Meldrum's acid, malonates, or other dicarbonyls. The Journal of organic chemistry 73 (19),
  • Boisvert L , Beaumier F , Spino C. (2007). Evidence for a concerted [4 + 1]- cycloaddition between electron-rich carbenes and electron-deficient dienes. Organic letters 9 (26),
  • Berrougui H , Cherki M , Koumbadinga GA , Isabelle M , Douville J , Spino C , Khalil A. (2007). Antiatherogenic activity of extracts of Argania spinosa L. pericarp: beneficial effects on lipid peroxidation and cholesterol homeostasis. Canadian journal of physiology and pharmacology 85 (9),
  • Perreault S , Spino C. (2006). Meldrum's acid-derived thione dienophile in a convergent and stereoselective synthesis of a tetracyclic quassinoid intermediate. Organic letters 8 (20),
  • Roy S , Spino C. (2006). Stereocontrolled formation of amino acids and N-heterocycles bearing a quaternary chiral carbon. Organic letters 8 (5),
  • Dion A , Dubé P , Spino C. (2005). A triple diene-transmissive Diels-Alder strategy to build the quassinoid framework. Organic letters 7 (25),
  • Gagnon D , Lauzon S , Godbout C , Spino C. (2005). Sterically biased 3,3-sigmatropic rearrangement of azides: efficient preparation of nonracemic alpha-amino acids and heterocycles. Organic letters 7 (21),

Chapitres de livre

  • Spino, Claude. (2009). Copper-mediated asymmetric allylic alkylations. Chemistry of Organocopper Compounds (1st, 2, 603-691). Wiley & Sons. (Published).

Propriétés intellectuelles

Patents

  • (2014). Organic superacid monomers containing a bis-sulfonic acid group and methods of making and using the same. US 8, 658, 706 B2. (Completed).
  • (2012). ORGANIC SUPERACID MONOMERS CONTAINING A BIS-SULFONIC ACID GROUP AND METHODS OF MAKING AND USING THE SAME. US2012/277332. (Completed).
  • (2009). Organic superacids, polymers derived from organic superacids, and making membranes for fuel cell applications. US 20090043068. (Completed).

Autres contributions

Gestion d'évènements

  • Principal Organizer. 94th Canadian Chemistry Conference & Exhibition Symposium on Natural Products. (Conference).
  • Prinicipal Organizer. Journée Sherbrooke - Montpellier (France) Symposium on medicinal chemistry and organic synthesis. (Conference).

Présentations

  • (2014). Formal synthesis of (+)-gephyrotoxin C. 97th Canadian Chemistry Conference. Vancouver
  • (2014). Carbenes and dienes. Gilead conference series. Seattle
  • (2014). Carbenes and dienes. UBC lecture series. Vancouver
  • (2013). Making chiral quaternary carbons. University of Waterloo, Invited Seminar Series. Waterloo
  • (2012). Syntheses of alkaloids and terpenoids from a climbers’ point of view. Dalhousie University, Invited Seminar Series. Halifax
  • (2012). Making chiral quaternary carbons. Sidney University, Invited Seminar Series. Sidney
  • (2012). Making chiral quaternary carbons. University of New South Wales, Invited Seminar Series. Sidney
  • (2012). Making chiral quaternary carbons. Eskitis Institute, Griffith University, Invited Seminar Series. Brisbane
  • (2012). Synthesis of alkaloids using a chiral auxiliary cleavable by metathesis. International Conference on Chemical Sciences. Colombo
  • (2012). Making chiral quaternary carbons. Australia National University, Invited Seminar Series. Canberra
  • (2012). Ring contraction of N-activated lactams. 95th Canadian Chemical Conference & Exhibition – Symposium on Advances in Synthesic Methods. Calgary
  • (2011). Allylic azides (of course) but mostly (4+1)-Cycloadditions. University of Toronto, Invited Seminar Series. Toronto
  • (2011). Synthesis of hetero-polycyclic compounds using formal [4+1]-cycloadditions. Mid-Atlantic Regional Meeting (MARM). College Park
  • (2010). Six synthèses d'alcaloïdes vues par un grimpeur. Université de Montréal, Invited Seminar Series. Montreal
  • (2010). Synthèse d'acides aminés chiraux non-naturels. Journée Sherbrooke - Montpellier. Sherbrooke
  • (2010). A climbers’ view of the synthesis of six alkaloids. 93rd Canadian Chemical Conference & Exhibition. Toronto
  • (2009). A climbers’ view of the synthesis of 6 alkaloids. University of Ottawa, Invited Seminar Series. Ottawa
  • (2009). Cycloadditions-[4+1]. Université de Rennes 1, Invited Seminar Series. Rennes
  • (2009). Six synthèses d'alcaloïdes vues par un grimpeur. Université Parix XI (Paris Sud), Invited Seminar Series. Gif sur Yvette
  • (2009). Six synthèses d'alcaloïdes vues par un grimpeur. Université de Bretagne Occidentale, Invited Seminar Series. Brest
  • (2009). Les quassinoïdes. Université de Caen, Invited Seminar Series. Caen
  • (2009). Six synthèses d'alcaloïdes vues par un grimpeur. Université de Rennes 1, Invited Seminar Series. Rennes
  • (2009). Six synthèses d'alcaloïdes vues par un grimpeur. Université Catholique de Louvain-La-Neuve, Invited Seminar Series. Louvain La Neuve
  • (2009). A climbers’ view of the synthesis of 6 alkaloids. University of Western Ontario (now Western University), Invited Seminar Series. London
  • (2007). Exposition de synthèse multi-étape. Université du Québec à Montréal, Invited Seminar Series. Montreal
  • (2007). Alternative à l'alkylation des énolates chiraux. Université Laval, Invited Seminar Series. Quebec