Claire Dubois

Prix et distinctions

• (2024) Honorary Member of the editorial bord. (Honneur).
• (2004) Senior Investigator. (Prix / Récompense).
• (2000) JuniorII Investigator. (Prix / Récompense).
• (1996) JuniorI Investigator. (Prix / Récompense).
• (1992) Fonds de dotation de l'Université de Sherbrooke. (Prix / Récompense).
• (1991) Post-doctoral fellow. (Prix / Récompense).
• (1988) Studentship Award (Ph.D). (Prix / Récompense).
• (1986) Studentship Award (M.Sc, Ph.D). (Prix / Récompense).
• Conférencier Pfizer. (Distinction).
• Gordon Research Award. (Distinction).
• Gordon research Award. (Distinction).
• Institute of Cancer (CIHR) publication Prize. Instituts de recherche en santé du Canada. (Prix / Récompense).
• Manuscript primed by F1000. (Distinction).
• Top ten discovery of the year. (Distinction).

Publications

Articles de revue

• *Arsenault, D.Charbonneau, M., *Roy, *LO, Lucien, F., and Dubois, CM. (*: STUDENTS. (2015). A conserved histidine residue in the mammalian TGFβ1 propeptide uses organelle pH forproteolytic processing and invadosome formation in cancer cells. FASEB journal (Article soumis).
• # Charbonneau, M.,*#R. Lavoie,R* Lauzier, A., *Harper, K.,McDonald, PP., Dubois, CM.; #: Co-first authors. (2015). Platelet-derived growth factor receptor activation promotes the pro-degradative invadosome-forming phenotype of synoviocytes from rheumatoid arthritis patients. J. Immunol (Révisions requises).
• * Lauzier,A., *R. Lavoie, R., *Gouin-Boisvert, B., *Harper, K., Charbonneau, M., Dubois, CM. (2015). Snail as a critical mediator of invadosome formation and joint degradation in arthritis. American Journal of Pathology (Article sous presse).
• Stéphanie Sylvain-Prévost, Thornin Ear*, François A. Simard, Carl F. Fortin, Claire M. Dubois Nicolas Flamand, and Patrick P. McDonald*. (2015). Activation of TAK1 by chemotactic and growth factors, and its impact on human neutrophil signaling and functional responses. J. Immunol (Article sous presse).
• Renzhong Li, Lalita Uttarwar, Bo Gao, Martine Charbonneau, Claire M. Dubois, Joan C. Krepinsky. (2015). High Glucose Upregulates ADAM17 through HIF-alpha in Mesangial Cells. J. Biol Chem 28 (290), 21603-21614. (Article sous presse).
• Trensz F, *Lucien F, Couture V, Söllrald T, Drouin G, Rouleau AJ, Dubois CM, Grandbois M, Lacraz G, Grenier G. (2015). Increased microenvironment stiffness in damaged myofibers promotes myogenic progenitor cell proliferation. Skelet Muscle 5 (5), 1-16. (Article publié).
• Obama T, Takayanagi T, Kobayashi T, Bourne AM, Elliott KJ, Charbonneau M, Dubois CM, Eguchi S. (2015). Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1alpha. Am J Hypertens. 28 (1), 10-14. (Article publié).
• *Lucien, F., *Harper, K., *Pelletier, PP., Volkov, L., Dubois, CM. (2014). Simultaneous pH measurement in endocytic and cytosolic compartments in living cells using confocal microscopy. J Vis Exp 28 (86), 1-7. (Article publié).
• Mayer TZ , Simard FA , Cloutier A , Vardhan H , Dubois CM , McDonald PP. (2013). The p38-MSK1 Signaling Cascade Influences Cytokine Production through CREB and C/EBP Factors in Human Neutrophils. Journal of immunology (Baltimore, Md. : 1950) 191 (8), 4299-4307. (Article publié).
• *Arsenault D , *Brochu-Gaudreau K , Charbonneau M , Dubois CM. (2013). HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion. PLoSONE 8 (2), 1-13. (Article publié).
• *Lauzier A, Charbonneau M , Paquette M , *Harper K , Dubois CM. (2012). Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis. Arthritis research & therapy 14 (4), 1-14. (Article publié).
• *Arsenault D , *Lucien F , Dubois CM. (2012). Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface. Journal of cellular physiology 227 (2), 789-800. (Article publié).
• *Lauzier A , Charbonneau M , *Harper K , Jilaveanu-Pelmus M , Dubois CM. (2011). Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src. Arthritis and Rheumatism 63 (6), 1591-1602. (Article publié).
• *Poulin S , Thompson C , Thivierge M , Véronneau S , *McMahon S , Dubois CM , Stankova J , Rola-Pleszczynski M. (2011). Cysteinyl-leukotrienes induce vascular endothelial growth factor production in human monocytes and bronchial smooth muscle cells. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 41 (2), 204-217. (Article publié).
• *Lucien F ,* Brochu-Gaudreau K , *Arsenault D , *Harper K , Dubois CM. (2011). Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK).(). PloSONE 6 (12), 1-11. (Article publié).
• *Harper K , Arsenault D , *Boulay-Jean S. , *Lauzier A , *Lucien F , Dubois CM. (2010). Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation. (). Cancer research 70 (11), 4634-4643. (Article publié).
• Cloutier A , Guindi C , Larivée P , Dubois CM , Amrani A , McDonald PP. (2009). Inflammatory cytokine production by human neutrophils involves C/EBP transcription factors. Journal of immunology (Baltimore, Md. : 1950) 182 (1), (Article publié).
• Thompson C , *McMahon S , Bossé Y , Dubois CM , Stankova J , Rola-Pleszczynski M. (2008). Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling. American journal of respiratory cell and molecular biology 39 (2),

Propriétés intellectuelles

Brevets

• Recombinant baculovirus vectors and insect host expressing a protein convertase, particularly furin, and a proteic precursor cleavable thereby, particularly pro-TGFβ. File # 60027356 (USA), 2 October 1996. (Terminé).
• Use of Furin and Furin-like Protease inhibitors in the Treatment of Inflammatory or Matrix Remodeling Diseases. File # 85761-12 (Canada) and 85761-13 (USA), 23 July 2000. (Terminé).

Licences

• New method to produce recombinant proteins in insect cells.(09/1998-09/2013). (Licence obtenue).
• Use of the baculovirus TGFß production system, (05/2000-05/2001). (Licence obtenue).

Autres contributions

Gestion d'évènements

• Member of the scientific committee. Gordon Research Conference on Proprotein Trafficking and Secretion (Colby-Sawyer College, New London, USA). (Conférence).
• Session Chair. International Conference on Tumor Hypoxia and Malignant Progression (Kyiv, Ukraine ). (Conférence).

Présentations

• (2015). LPA receptors and EGFR cooperate for hypoxia-induced invadopodia production.(Best poster award (HK); and Canadian Cancer Society travel award (HK)). FASEB SRC: Lysophospholipids and Related Mediators - From Bench to Clinic. Banff
• (2015). Selective up regulation of Smad3 signalling in hypoxia promotes invadopodia production. TGF-b Superfamily: Signaling in Development and Disease. Snowmass
• (2015). Platelet-derived growth factor receptor activation promotes the pro-degradative invadosome-forming phenotype of synoviocytes from patients with rheumatoid arthritis. 3rd World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases. Montreal
• (2015). Snail promotes invadosome formation and joint degradation in arthritis. 3rd World Congress on Controversies, Debates 7 Consensus in Bone Muscle & Joint Diseases. Montreal
• (2014). Cooperation entre les récepteurs LPAR et EGFR dans l’induction hypoxique des invadopodes chez les cellules tumorales. 56e Reunion annuelle du CRCQ. Sainte-Adèle
• (2014). Le nouveau rôle de la protéine adaptatrice Tks4 dans le recrutement de la MT1-MMP aux invadosomes. 56e Reunion annuelle du CRCQ. Sainte-Adèle
• (2014). LPA receptors and EGFR cooperate for hypoxia-induced invadopodia production. Colloque d'immuno-inflammation. Eastman
• (2013). Consequences of Furin Trafficking in Cancer. 10th Symposium on the Physiology and Diseases of the Digestive Track. Orford
• (2012). Quand les cellules cancéreuses font de la résistance. 80ème Congrès de l’Association francophone pour le Savoir. Montreal
• (2011). The LPA receptors LPA4 and LPA1 cooperate for hypoxia-induced invadopodia production. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease. Lucca
• (2011). The LPA receptors LPA4 and LPA1 cooperate for hypoxia-induced invadopodia production. Montreal International Symposium on Angiogenesis and Metastasis. Montreal
• (2011). Hypoxia-induced invadopodia formation involves activation of NHE-1 by p90RSK. Montreal International Symposium on Angiogenesis and Metastasis. Montreal
• (2010). Regulation of tumor cell invasion by NHE1-induced extracellular acidification.(Best poster prize (FL). 5th International Conference on Tumor Microenvironment : Progression, Therapy and Prevention. Versailles
• (2010). Rôle du microenvironnement tumoral dans l’invasion des cellules cancéreuses. 51è réunion annuelle du CRCQ. Bromont
• (2010). Implication of autotaxin in the hypoxic induction of invadopodia. The new York Academy of Sciences conférence on Hypoxia and Consequences : From Molecule to Malady. New-York
• (2010). Impact of hypoxia on proprotein convertases trafficking. The new York Academy of Sciences conférence on Hypoxia and Consequences : from Molecule to Malady. New-York
• (2010). LPA receptor4 mediates Autotaxin-induced Invadopodia production and Invasion.(Best poster prize(HK)). Signalisation Québec. Orford
• (2010). La formation d’invadopodes par les cellules synoviales promeut la degradation du cartilage dans l’arthrite expérimentale. Signalisation Québec. Orford
• (2010). Regulation of tumor cell invadopodia by hypoxia-induced NHE-1 activation. 21st Meeting of the European Association for Cancer Research. Oslo
• (2010). LPA Receptor 4 mediates Autotaxin-induced Invadopodia production and Invasion. 21st Meeting of the European Association for Cancer Research. Oslo
• (2010). Furin Trafficking in Tumor Cell Invasion. Gordon Research Conference on Proprotein Trafficking and Secretion. New London
• (2010). Impact of hypoxia on furin trafficking and the formation of invadopodia. 21st Meeting of the European Association for Cancer Research. Oslo
• (2010). La formation d’invadopodes par les cellules synoviales promeut la degradation du cartilage dans l’arthrite expérimentale. Signalisation Québec. Orford
• (2010). LPA receptor 4 mediates autotaxin-induced invadopodia production and invasion. Colloque d’immuno-inflammation. Eastman