Benoît Chabot

Prix et distinctions

• (2020) Chaire de recherche Pierre C. Fournier. Université de Sherbrooke. (Prix / Récompense).
• (2015) Canada Research Chair in Functional Genomics. Canada Research Chair. (Prix / Récompense).
• (2011) Canadian Researcher of the Month. Canadian for Health Research. (Distinction).
• Fellow CAHS. Académie Canadienne des sciences de la santé. (Distinction).
• NRC Press Senior Investigator Award of Canadian Society for Molecular Biosciences. CSMB. (Prix / Récompense).
• Research Award JIOMICS & Proteomass Scientific Society. JIOMICS and Proteomass Scientific Society. (Prix / Récompense).

Financement

• Subvention. (En cours d’évaluation). Co-chercheur. Automation of protein and precipitant pipetting for crystal screening campaign. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Outils et instruments de recherche. 200 000 $. (2020-2025)
• Subvention. (En cours d’évaluation). Co-demandeur. Telomeres and the control of alternative splicing during cellular senescence. Instituts de Recherche en Santé du Canada (IRSC). Subvention. 1 170 000 $. (2020-2025)
• (Obtenu). Co-demandeur. Total liquid ventilation for bronchopulmonary dysplasia prevention in a model of extreme preterm lamb. Instituts de Recherche en Santé du Canada (IRSC). New Investigator Grants in Maternal, Reproductive, Child & Youth Health. 105 000 $. (2020-2023)
• Subvention. (Terminé). Co-chercheur. An antibody delivery system that overcomes endosome entrapment for effective siRNA therapy. IPS-Projet Innovant. Projet Innovant. 40 000 $. (2017-2018)
• Subvention. (Terminé). Co-demandeur. RTI -FPLC. CRSNG. RTI. 138 000 $. (2017)
• Subvention. (Terminé). Co-chercheur. Évaluation de la réponse inflammatoire pulmonaire de la ventilation liquidienne et gazeuse chez l’ovin néonatal en déficit en surfactant. CRCHUS. PAFI. 25 000 $. (2016-2017)
• Subvention. (Terminé). Co-chercheur. Alternative splicing of FGFR4 in hepatocellular carcinoma. Université de Sherbrooke. CRIODUS. 10 000 $. (2016-2017)

Publications

Articles de revue

• Deshaies, J.E., Shkreta, L.*, Moszczynski, A.J., Flamier, A., Sidibe, H., Semmler, S., Fouillen, A., Bennet, E., Bekenstein, U., Destroismaisons, L., Toutant, J.*, Delmotte Q., Volkening, K., Stabile, S., Aulas, A., Khalfallah, Y., Soreq, H., Nanci, A., Bernier, G., Strong, M.J., Chabot, B. and Vande Velde, C. (2018). TDP-43 regulates hnRNP A1 alternative splicing to generate an aggregation prone isoform in amyotrophic lateral sclerosis. Brain 141 (5), 1320-1333. (Article publié).
• Cloutier, A*., Barbier, J*., Toutant, J.*, Durand, M., Lapointe, E., Thibault, P. and Chabot, B. (2018). Transiently depleting RNPS1 promote perdurable changes in alternative splicing. BioRvX 141 (1), 1-20. (Article soumis).
• Cloutier, A*., Shkreta, L.*, Durand, M., Toutant, J.*, Thibault, P. and Chabot, B. (2018). hnRNP A1/A2 and Sam68 collaborate with SRSF10 to control the splicing response to oxaliplatin-mediated DNA damage. Scientific Reports 8 (1), 2208. (Article publié).
• Bondy-Chorney, E., Baldwin, R.M., Didillon, A., Chabot, B., Jasmin, B.J. and Côté, J. (2017). Altered expression of splicing factors SNW1 and RALY leads to misregulation of protein arginine methyltransferase 1 exon 2 alternative splicing and increased invasion in breast cancer cells. Int. J. Biochem. & Cell Biol. 91 124-135. (Article publié).
• Shkreta, L.*, Blanchette, M., Toutant, J.*, Wilhem, E., Bell, B., Story, B. A., Cochrane, A., Cheung, P. K., Harrigan, P.R., Grierson, D. and Chabot, B. (2017). Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication. Nucl. Acids Res. 45 (7), 4051-4067. DOI. (Article publié).
• Sutherland, L.C., Thibault, P., Durand, M., Lapointe, E., Knee J.M., Beauvais, A., Kalatskaya I., Hunt, S.C., Loiselle, J.J., Roy, J.G., Tessier, S.J., Ybazeta, G., Stein, L., Kotary, R., Klinck, R., Chabot, B. (2017). Splicing arrays reveal novel RBM10 targets, including SMN2 pre-mRNA. BMC Molecular Biology 18 (1), 19. (Article publié).
• Cloutier, P., Hekmat, O., Poitras, C., Durand, M., Fiola-Masson, E., Bouchard, A., Faubert, D., Chabot, B. and B. Coulombe. (2017). The RUVBL1/RUVBL2 component of the cochaperone R2TP/Prefoldin-like directly interacts with ZNHIT2 to regulate assembly of the small nuclear ribonucleoprotein U5. Nature Communications 8 15615. DOI. (Article publié).
• Mathieu Deschênes*, Benoit Chabot. (2017). The emerging role of alternative splicing in senescence and aging. Aging Cell 16 (5), 918-933. DOI. (Article publié).
• Shkreta, L*., Toutant, J.*, Durand, M., Manley, J.L. and Chabot, B. (2016). Cell Reports 17 (8), 1990-2003. (Article publié).
• Peter K. Cheung , David Horant , Laura E. Bandy , Maryam Zamiri , Safwat M. Rabea, Stoyan K. Karagiosov, Mitra Matloobi, Steven McArthur, P. Richard Harrigan, Benoit Chabot, and David S. Grierson. (2016). A parallel synthesis approach to the identification of novel diheteroarylamide-based compound blocking HIV replication: potential inhibitors of HIV-1 pre-mRNA alternative splicing. Journal of Medicinal Chemistry 59 (5), 1869-1879. (Article publié).
• Chabot B. and Shkreta L.*. (2016). Defective control of pre-messenger RNA splicing in human disease. Journal of Cell Biology 212 (1), 13-27. (Article publié).
• Bondy-Chorney, E., Crawford, T. E., Ravel-Chapuis, A., Klinck, R., Chabot, B., Jasmin, B. J., and Côté, J. (2016). Staufen1 regulates multiple alternative splicing events through intronic Alu elements which ameliorates or exacerbates the myotonic dystrophy type I phenotype. PLoS Genetics 12 (1), 1-22. DOI. (Article publié).
• Lemieux, B.*, Blanchette, M., Monette, A., Mouland, A.J., J.F., Wellinger, R.J. and Chabot, B. (2015). A function for hnRNP A1 and A2 in transcription elongation. PLoS One 10 (5), e0126654. (Article publié).
• Mauger, O., Klinck, R., Chabot, B., Muchardt, C., Allemand, E. and Batsché, E. (2015). Alternative splicing regulates the expression of G9A and SUV39H2, and dramatically changes SUV39H2 functions. Nucleic Acids Research 43 1869-1882. (Article publié).
• B. Chabot. (2015). Finding the rules and using them ... alternatively. RNA 4 582-583. (Article publié).
• B. Chabot. (2015). My road to alternative splicing control: from simple paths to loops and interconnections. Biochem. Cell. Biol. 3 171-179. (Article publié).
• Bergeron, D., Pal, G., Beaulieu, Y.B., Chabot, B. and Bachand, F. (2015). Regulated intron retention and nuclear pre-mRNA decay contribute to PABPN1 autoregulation. Mol. Cell. Biol. 35 (14), 2503-2517. (Article publié).
• Shkreta, L.*, Cloutier, A.*, Toutant, J.*, Vennin Rendos, H.* and Chabot, B. (2015). Regulation of alternative splicing and the case of Bcl-x. Pakistan Journal of Biochemistry and Molecular Biology 48 (2), 27-38. (Article publié).
• Gabriel, M., Delforge, Y., Deward, A., Habraken, Y., Hennuy, B., Piette, J., Klinck, R., Chabot, B., Colige, A. and Lambert, C. (2015). Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis. BMC Cancer 15 1-14. (Article publié).
• Lulzim Shkreta* and Benoit Chabot. (2015). The RNA splicing response to DNA damage. Biomolecules 5 2935-2977. (Article publié).
• Best, A., James, K., Dalgliesh, C., Hong, E., Kheirolahi-Kouhestani, M., Curk, T., Xu, Y., Danilenko, M., Hussain, R., Keavney, B., Wipat, A., Klinck, R., Cowell, I., Lee, K. C., Austin, C., Venables, J., Chabot, B., Santibanez Koref, M., Tyson-Capper, A. and D. J. Elliott. (2014). Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons. Nature Communications 5 4560. (Article publié).
• Klinck, R., Fourrier, A., Thibault, P., Toutant, J., Durand, M., Lapointe, E., Caillet-Boudin, M.-L., Sergeant, N., Gourdon, G., Meola, G., Furling, D., Puymirat, J., Chabot, B. (2014). RBFOX1 cooperates with MBNL1 to control splicing in muscle, including events altered in myotonic dystrophy type 1. PLOS One 9 (9), e107324. (Article publié).
• Brosseau JP , Lucier JF , Lamarche AA *, Shkreta L *, Gendron D , Lapointe E , Thibault P , Paquet E , Perreault JP , Abou Elela S , Chabot B. (2014). Redirecting splicing with bifunctional oligonucleotides. Nucleic acids research 42 e40. (Article publié).
• Brosseau JP , Lucier JF , Nwilati H , Thibault P , Garneau D , Gendron D , Durand M , Couture S , Lapointe E , Prinos P , Klinck R , Perreault JP , Chabot B , Abou-Elela S. (2014). Tumor microenvironment-associated modifications of alternative splicing. RNA (New York, N.Y.) 20 (2), 189-201. (Article publié).
• Venables JP , Lapasset L , Gadea G , Fort P , Klinck R , Irimia M , Vignal E , Thibault P , Prinos P , Chabot B , Abou Elela S , Roux P , Lemaitre JM , Tazi J. (2013). MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nature communications 4 2480 doi: 10.1038/nc. (Article publié).
• Diaz Z , Aguilar-Mahecha A , Paquet ER , Basik M , Orain M , Camlioglu E , Constantin A , Benlimame N , Bachvarov D , Jannot G , Simard MJ , Chabot B , Gologan A , Klinck R , Gagnon-Kugler T , Lespérance B , Samson B , Kavan P , Alcindor T , Dalfen R , Lan C , Chabot C , Buchanan M , Przybytkowski E , Qureshi S , Rousseau C , Spatz A , Têtu B , Batist G. (2013). Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine. Modern Pathology 26 1413-1424. (Article publié).
• Venables JP , Brosseau JP , Gadea G , Klinck R , Prinos P , Beaulieu JF , Lapointe E , Durand M , Thibault P , Tremblay K , Rousset F , Tazi J , Abou Elela S , Chabot B. (2013). RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Molecular and Cellular Biology 33 (2), 396-405. (Article publié).
• Prinos, P., Klinck, R., Venables, J.P., Perreault, J.P., Wellinger, R.J., Abou Elela, S. and Chabot, B. (2012). Alternative splicing as a generator of functional diversity in cancer. MSA 1 (4), 151-165. (Article publié).
• Lund N , Milev MP , Wong R , Sanmuganantham T , Woolaway K , Chabot B , Abou Elela S , Mouland AJ , Cochrane A. (2012). Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression. Nucleic acids research 40 (8), 3663-3675. (Article publié).
• Michelle L* , Cloutier A* , Toutant J*, Shkreta L* , Thibault P , Durand M , Garneau D , Gendron D , Lapointe E , Couture S , Le Hir H , Klinck R , Elela SA , Prinos P , Chabot B. (2012). EJC components modulate the alternative splicing of Bcl-x and other apoptotic genes. Molecular and cellular biology 32 (5), 954-967. (Article publié).
• Montes M , Cloutier A* , Sánchez-Hernández N , Michelle L* , Lemieux B* , Blanchette M , Hernández-Munain C , Chabot B , Suñé C. (2012). TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription. Molecular and cellular biology 32 (4), 751-762. (Article publié).
• Prinos P , Garneau D , Lucier JF , Gendron D , Couture S , Boivin M , Brosseau JP , Lapointe E , Thibault P , Durand M , Tremblay K , Gervais-Bird J , Nwilati H , Klinck R , Chabot B , Perreault JP , Wellinger RJ , Elela SA. (2011). Alternative splicing of SYK regulates mitosis and cell survival. Nature structural & molecular biology 18 (6), 673-679. (Article publié).
• Parenteau J , Durand M , Morin G , Gagnon J , Lucier JF , Wellinger RJ , Chabot B , Elela SA. (2011). Introns within ribosomal protein genes regulate the production and function of yeast ribosomes. Cell 147 (2), 320-331. (Article publié).
• Tanackovic G , Ransijn A , Thibault P , Abou Elela S , Klinck R , Berson EL , Chabot B , Rivolta C. (2011). PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. Human molecular genetics 20 (11), 21116-21130. (Article publié).
• Shkreta L , Michelle L , Toutant J , Tremblay ML , Chabot B. (2011). The DNA damage response pathway regulates the alternative splicing of the apoptotic mediator Bcl-x. The Journal of Biological Chemistry 286 (1), 331-340. (Article publié).
• Dominguez C , Fisette JF , Chabot B , Allain FH. (2010). Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. Nature Structural & Molecular Biology 17 (7), 853-851. (Article publié).
• Fisette JF , Toutant J , Dugré-Brisson S , Desgroseillers L , Chabot B. (2010). hnRNP A1 and hnRNP H can collaborate to modulate 5' splice site selection. RNA (New York, N.Y.) 16 (1), 228-238.
• Venables JP , Klinck R , Koh C , Gervais-Bird J , Bramard A , Inkel L , Durand M , Couture S , Froehlich U , Lapointe E , Lucier JF , Thibault P , Rancourt C , Tremblay K , Prinos P , Chabot B , Elela SA. (2009). Cancer-associated regulation of alternative splicing. Nature Structural & Molecular Biology 16 (6), 670-676.
• Alló M , Buggiano V , Fededa JP , Petrillo E , Schor I , de la Mata M , Agirre E , Plass M , Eyras E , Elela SA , Klinck R , Chabot B , Kornblihtt AR. (2009). Control of alternative splicing through siRNA-mediated transcriptional gene silencing. Nature structural & molecular biology 16 (7), 717-724.
• Revil T , Pelletier J , Toutant J , Cloutier A , Chabot B. (2009). Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform. The Journal of biological chemistry 284 (32), 21458-21467.
• Fisette JF , Michelle L , Revil T , Chabot B. (2009). [Guiding and integrating to control and diversify splicing]. Médecine Sciences 25 (2),
• Cloutier P , Toutant J , Shkreta L , Goekjian S , Revil T , Chabot B. (2008). Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x. The Journal of biological chemistry 283 (31), 21315-21324.
• Shkreta L , Froehlich U , Paquet ER , Toutant J , Elela SA , Chabot B. (2008). Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes. Molecular cancer therapeutics 7 (6), 1398-1409.
• Chabot B , Elela SA , Zhuo D. (2008). Comment on "When good transcripts go bad: artifactual RT-PCR 'splicing' and genome analysis". BioEssays 30 (11-12),
• Parenteau J , Durand M , Véronneau S , Lacombe AA , Morin G , Guérin V , Cecez B , Gervais-Bird J , Koh CS , Brunelle D , Wellinger RJ , Chabot B , Abou Elela S. (2008). Deletion of many yeast introns reveals a minority of genes that require splicing for function. Molecular biology of the cell 19 (5), 1932-1941.
• Venables JP , Klinck R , Bramard A , Inkel L , Dufresne-Martin G , Koh C , Gervais-Bird J , Lapointe E , Froehlich U , Durand M , Gendron D , Brosseau JP , Thibault P , Lucier JF , Tremblay K , Prinos P , Wellinger RJ , Chabot B , Rancourt C , Elela. (2008). Identification of alternative splicing markers for breast cancer. Cancer Research 68 (22), 9525-9531.
• Klinck R , Bramard A , Inkel L , Dufresne-Martin G , Gervais-Bird J , Madden R , Paquet ER , Koh C , Venables JP , Prinos P , Jilaveanu-Pelmus M , Wellinger R , Rancourt C , Chabot B , Abou Elela S. (2008). Multiple alternative splicing markers for ovarian cancer. Cancer Research 68 (3), 657-663.
• Venables JP , Koh CS , Froehlich U , Lapointe E , Couture S , Inkel L , Bramard A , Paquet ER , Watier V , Durand M , Lucier JF , Gervais-Bird J , Tremblay K , Prinos P , Klinck R , Elela SA , Chabot B. (2008). Multiple and specific mRNA processing targets for the major human hnRNP proteins. Molecular and Cellular Biology 28 (19), 6033-6043.
• Zhuo D , Madden R , Elela SA , Chabot B. (2007). Modern origin of numerous alternatively spliced human introns from tandem arrays. Proceedings of the National Academy of Sciences of the United States of America 104 (3), 882-886.
• Revil T , Toutant J , Shkreta L , Garneau D , Cloutier P , Chabot B. (2007). Protein kinase C-dependent control of Bcl-x alternative splicing. Molecular and Cellular Biology 27 (24), 8431-8441.
• Bakkour N , Lin YL , Maire S , Ayadi L , Mahuteau-Betzer F , Nguyen CH , Mettling C , Portales P , Grierson D , Chabot B , Jeanteur P , Branlant C , Corbeau P , Tazi J. (2007). Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance. PLoS Pathogens 3 (10), 1530-1539.
• Jeronimo C , Forget D , Bouchard A , Li Q , Chua G , Poitras C , Thérien C , Bergeron D , Bourassa S , Greenblatt J , Chabot B , Poirier GG , Hughes TR , Blanchette M , Price DH , Coulombe B. (2007). Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Molecular Cell 27 (2), 262-274.
• Paradis C , Cloutier P , Shkreta L , Toutant J , Klarskov K , Chabot B. (2007). hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c. RNA 13 (8), 1287-1300.
• Martinez-Contreras R , Cloutier P , Shkreta L , Fisette JF , Revil T , Chabot B. (2007). hnRNP proteins and splicing control. Advances in Experimental Medicine and Biology 623 123-147.
• Martinez-Contreras R , Fisette JF , Nasim FU , Madden R , Cordeau M , Chabot B. (2006). Intronic binding sites for hnRNP A/B and hnRNP F/H proteins stimulate pre-mRNA splicing. PLoS Biology 4 (2), 172-185.
• Gendron D , Carriero S , Garneau D , Villemaire J , Klinck R , Elela SA , Damha MJ , Chabot B. (2006). Modulation of 5' splice site selection using tailed oligonucleotides carrying splicing signals. BMC Biotechnology 6 (5), 12 pages.
• Revil T , Shkreta L , Chabot B. (2006). [Pre-mRNA alternative splicing in cancer: functional impact, molecular mechanisms and therapeutic perspectives]. Bulletin du cancer 93 (9),
• Garneau D , Revil T , Fisette JF , Chabot B. (2005). Heterogeneous nuclear ribonucleoprotein F/H proteins modulate the alternative splicing of the apoptotic mediator Bcl-x. The Journal of Biological Chemistry 280 (24), 22641-22650.
• Naud JF , McDuff FO , Sauvé S , Montagne M , Webb BA , Smith SP , Chabot B , Lavigne P. (2005). Structural and thermodynamical characterization of the complete p21 gene product of Max. Biochemistry 44 (38), 12746-12758.
• Bériault V , Clément JF , Lévesque K , Lebel C , Yong X , Chabot B , Cohen EA , Cochrane AW , Rigby WF , Mouland AJ. (2004). A late role for the association of hnRNP A2 with the HIV-1 hnRNP A2 response elements in genomic RNA, Gag, and Vpr localization. The Journal of Biological Chemistry 279 (42), 44141-44153.
• Patry C , Lemieux B , Wellinger RJ , Chabot B. (2004). Targeting heterogeneous nuclear ribonucleoparticule A1 and A2 proteins by RNA interference promotes cell death in transformed but not in normal mouse cell lines. Molecular Cancer Therapeutics 3 (10), 1194-1199.
• Gagné JP , Hunter JM , Labrecque B , Chabot B , Poirier GG. (2003). A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins. The Biochemical Journal 371 (2), 331-340.
• Jean-François N , Frédéric G , Raymund W , Benoit C , Lavigne P. (2003). Improving the thermodynamic stability of the leucine zipper of max increases the stability of its b-HLH-LZ:E-box complex. Journal of Molecular Biology 326 (5), 1577-1595.
• Villemaire J , Dion I , Elela SA , Chabot B. (2003). Reprogramming alternative pre-messenger RNA splicing through the use of protein-binding antisense oligonucleotides. The Journal of Biological Chemistry 278 (50), 50031-50039.
• Patry C , Bouchard L , Labrecque P , Gendron D , Lemieux B , Toutant J , Lapointe E , Wellinger R , Chabot B. (2003). Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines. Cancer Research 63 (22), 7679-7688.
• Robert F , Blanchette M , Maes O , Chabot B , Coulombe B. (2002). A human RNA polymerase II-containing complex associated with factors necessary for spliceosome assembly. The Journal of Biological Chemistry 277 (11), 9302-9306.
• Hutchison S , LeBel C , Blanchette M , Chabot B. (2002). Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (hnRNP) A1/A2 binding sites control 5' splice site selection in the hnRNP A1 mRNA precursor. The Journal of Biological Chemistry 277 (33), 29745-29752.
• Nasim FU , Hutchison S , Cordeau M , Chabot B. (2002). High-affinity hnRNP A1 binding sites and duplex-forming inverted repeats have similar effects on 5' splice site selection in support of a common looping out and repression mechanism. RNA 8 (8), 1078-1089.
• Simard MJ , Chabot B. (2002). SRp30c is a repressor of 3' splice site utilization. Molecular and Cellular Biology 22 (12), 4001-4010.
• Fang LJ , Simard MJ , Vidaud D , Assouline B , Lemieux B , Vidaud M , Chabot B , Thirion JP. (2001). A novel mutation in the neurofibromatosis type 1 (NF1) gene promotes skipping of two exons by preventing exon definition. Journal of Molecular Biology 307 (5), 1261-1270.
• Bolduc L , Labrecque B , Cordeau M , Blanchette M , Chabot B. (2001). Dimethyl sulfoxide affects the selection of splice sites. The Journal of Biological Chemistry 276 (20), 17597-17602.
• Fiset S , Chabot B. (2001). hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro. Nucleic Acids Research 29 (11), 2268-2275.
• Hutchison S, Simard MJ, Nasim FH, Cordeau M Chabot B. (2000). Alternative splicing of hnRNP A1: Complex control of a simple splicing event. Recent Res. Devel. Mol. Cell. Biol. 1 117-135. (Article publié).
• Simard MJ , Chabot B. (2000). Control of hnRNP A1 alternative splicing: an intron element represses use of the common 3' splice site. Molecular and Cellular Biology 20 (19), 7353-7362.
• Dallaire F , Dupuis S , Fiset S , Chabot B. (2000). Heterogeneous nuclear ribonucleoprotein A1 and UP1 protect mammalian telomeric repeats and modulate telomere replication in vitro. The Journal of Biological Chemistry 275 (19), 14509-14516.
• Côté J , Simard MJ , Chabot B. (1999). An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection. Nucleic Acids Research 27 (12),
• Blanchette M , Chabot B. (1999). Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization. The EMBO Journal 18 (7),
• LaBranche H , Dupuis S , Ben-David Y , Bani MR , Wellinger RJ , Chabot B. (1998). Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nature Genetics 19 (2),
• Blanchette M , Chabot B. (1997). A highly stable duplex structure sequesters the 5' splice site region of hnRNP A1 alternative exon 7B. RNA (New York, N.Y.) 3 (4),
• Chabot B , Blanchette M , Lapierre I , La Branche H. (1997). An intron element modulating 5' splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1. Molecular and Cellular Biology 17 (4),
• Côté J , Chabot B. (1997). Natural base-pairing interactions between 5' splice site and branch site sequences affect mammalian 5' splice site selection. RNA (New York, N.Y.) 3 (11),
• Granger D , Tremblay A , Boulanger C , Chabot B , Ménard HA , Boire G. (1996). Autoantigenic epitopes on hY5 Ro RNA are distinct from regions bound by the 60-kDa Ro and La proteins. Journal of immunology (Baltimore, Md. : 1950) 157 (5),
• Chabot B. (1996). Directing alternative splicing: cast and scenarios. Trends in Genetic 12 (11),
• Granger D , Gendron M , Tremblay A , Chabot B , Ménard HA , Boire G. (1996). RNA-labelled Ro and La ribonucleoprotein complexes reassembled in vitro; characterization by gel shift analysis. Clinical and experimental immunology 106 (3),
• Vincent M , Lauriault P , Dubois MF , Lavoie S , Bensaude O , Chabot B. (1996). The nuclear matrix protein p255 is a highly phosphorylated form of RNA polymerase II largest subunit which associates with spliceosomes. Nucleic acids research 24 (23),
• Boulanger C , Chabot B , Ménard HA , Boire G. (1995). Autoantibodies in human anti-Ro sera specifically recognize deproteinized hY5 Ro RNA. Clinical and Experimental Immunology 99 (1),
• Côté J , Beaudoin J , Tacke R , Chabot B. (1995). The U1 small nuclear ribonucleoprotein/5' splice site interaction affects U2AF65 binding to the downstream 3' splice site. The Journal of biological chemistry 270 (8),
• Chabot B , Bisotto S , Vincent M. (1995). The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/U6.U5] tri-snRNP particle. Nucleic acids research 23 (16),
• Yang X , Bani MR , Lu SJ , Rowan S , Ben-David Y , Chabot B. (1994). The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo. Proceedings of the National Academy of Sciences of the United States of America 91 (15),
• Lavigueur A , La Branche H , Kornblihtt AR , Chabot B. (1993). A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes & Development 7 (12A),
• Chabot B , Frappier D , La Branche H. (1992). Differential ASF/SF2 activity in extracts from normal WI38 and transformed WI38VA13 cells. Nucleic Acids Research 20 (19),
• Ben-David Y , Bani MR , Chabot B , De Koven A , Bernstein A. (1992). Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth. Molecular and cellular biology 12 (10),
• La Branche H , Frappier D , Chabot B. (1991). Proteolysis of splicing factors during rat and monkey cell fractionation. Nucleic acids research 19 (16),
• Bernstein A , Chabot B , Dubreuil P , Reith A , Nocka K , Majumder S , Ray P , Besmer P. (1990). The mouse W/c-kit locus. Ciba Foundation symposium 148
• Chabot, B. (1989). Des souris et des hommes: de la biologie moléculaire à la clinique. Can. Med. Assoc. J. 121 371. (Article publié).
• Nocka K , Majumder S , Chabot B , Ray P , Cervone M , Bernstein A , Besmer P. (1989). Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice. Genes & Development 3 (6),
• Chabot B , Stephenson DA , Chapman VM , Besmer P , Bernstein A. (1988). The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335 (6185),
• Chabot B , Steitz JA. (1987). Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Molecular and Cellular Biology 7 (1),
• Chabot B , Steitz JA. (1987). Recognition of mutant and cryptic 5' splice sites by the U1 small nuclear ribonucleoprotein in vitro. Molecular and Cellular Biology 7 (2),
• Chabot B , Black DL , LeMaster DM , Steitz JA. (1985). The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein. Science 230 (4732),
• Black DL , Chabot B , Steitz JA. (1985). U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing. Cell 42 (3),
• Sage, M., See, W., Nault, S., Morin, C., Michalski, C., Chabot, B., Marouan, S., Lavoie, P.M., Micheau, P., Praud, J.P., and Fortin-Pellerin, E. Effect of low versus high tidal-volume total liquid ventilation on pulmonary inflammation. Frontiers in Physiology (Article soumis).
• Nourreddine, S., Lavoie, G., Paradis, J., Méant, A., Aubert, L., El Kadhi, K.B., Gendron, P., Chabot, B., Bouvier, M., Carreno, S., Roux, P.R. The NF45-NF90 complex regulates mitotic gene expression to promote genomic stability and cell division. Cell Reports (Révisions requises).
• J. Chen, M. Rajasekaran, Y. Wang, Y. Qiao, H. Xia, A. Deivasigamani, K. Sekar, V. P. Seshachalam, H. Gao, C. Chang, H. Dong, Q. Li, L. Xu, Y. Chen, D. Chen, J. Gunaratne, W. Han, W. Hong, D. S. Grierson, B. Chabot, T. Xie, K. M. Hui. The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma. Hepatology (Article soumis).

Chapitres de livre

• Shkreta L, Bell B, Revil T, Venables JP, Prinos P, Abou Elela S, Chabot B. (2013). Cancer-associated perturbations in alternative pre-messenger RNA splicing. Jane Wu. RNA and Cancer (41-94). États-Unis : Springer, USA. (Article publié).
• Michelle L, Barbier J, Chabot B. (2012). hnRNP and hnRNP-like proteins in splicing control: molecular mechanisms and implication in human diseases. Z. Lorkovic. RNA binding proteins (1-25). États-Unis : Landes Biosciences. (Article publié).

Propriétés intellectuelles

Brevets

• (2009). Methods to regrogram splice site selection in pre-messenger RNAs. US2009/0186846 A1. États-Unis. (Délivré).
• (2003). Methods and compositions for treating neoplasia relating to hnRNP A1 and hnRnP A2 nucleic acid molecules. États-Unis. (Délivré).
• (2002). Methods for monitoring the binding of A1/UP1 to single-stranded nucleic acid sequences and to measure the effect of this binding on telomere extension and protection. 6,358,687. États-Unis. (Délivré).
• Alternative splicing gene variants in cancer detection. PCT/CA2008/001477 - WO 2009/021338. États-Unis. (Retiré).
• Bifunctional oligonucleotides stimulating splicing at 5'splice sites. 61/909,744. États-Unis. (Retiré).
• Composition and methods for modulating the length of telomeres. CA97/00471. US 6,294,332 B1. États-Unis. (Délivré).
• Composition and methods for modulation of alternative splicing. 8,546,346. États-Unis. (Retiré).
• Indole derivative compounds as therapeutics and methods for their use. 61/985,963. États-Unis. (En instance).
• Hélène Chabrolles, Thomas Lahlali, Benoit Chabot, David Grierson, David Durantel, Anna Salvetti. Methods for treating HBV infection. EP18305398.2. France. (En instance).
• Signature of secreted protein isoforms specific to ovarian cancer. États-Unis. (Retiré).

Autres contributions

Cours enseignés

• Me?thodes d’e?tudes de cibles pharmacologiques. PHR713. (2015-02-19 à 2016-06-17).Université de Sherbrooke. Canada. (2CR).
• Transcription et Maturations Post-Transcriptionnelles. MCR716. (1996-01-30).Université de Sherbrooke. Canada. (2CR).

Gestion d'évènements

• Chair. (2015-2021) Meetings Committee fo the RNA Society. (Association).

Activités de collaboration internationale

• collaborateur. France. Projet ANRS -Interaction of Hepatitis B virus Core protein(HBc) with cellular RNA binding factors and functional consequences on the HBV replication and hepatocyte physiology.
• co-organizer. Canada. co-organisateur du congrès Riboclub en partenariat avec Université de Montpellier.
• Accueil de stagiaire (post-doctorat). France. Stage à la Plateforme ARN Laure Lapasset Université de Montpellier.
• Accueil de stagiaire au doctorat. Espagne. Stagiaire (Ph.D.) Maria Montes Université de Granada.

Présentations

• (2020). Cibler les régulateurs d’épissage comme stratégie anti-cancer. Conférence CRMO-FC/UQAM. Montreal, Canada
• B. Chabot. (2019). Épissage et innovation. Congrès annuel du programme en biologie médicale UQTR. Trois-Rivières, Canada
• M. Deschênes* and B. Chabot. (2018). Alternative splicing alterations potentially contribute to apoptotic resistance associated with senescence. June 2018. Ste-Camille, QC. Cytokines in inflammation, ageing, cancer and obesity (CIACO) Meeting. St-Camille, Canada
• M. Deschênes* and B. Chabot. (2018). Alternative splicing in apoptotic resistance associated with senescence. International Cell Senescence Association Meeting. Montreal, Canada
• B. Chabot. (2018). Défauts d’épissage et maladies génétiques. Réunion annuelle de l'Association des médecins généticiens du Québec - Conférencier Marie-Lambert. Montréal, Canada
• N. Martínez-Montiel*, R. Martínez-Contreras, J. Toutant, E, Lapointe, M. Durand, P. Thibault, M. Scott, N. Rivard, J. Carrier, J.B. Denault, R. Leduc and B. Chabot. (2018). Reprogramming splicing events in cancer using new small molecules and an innovative. Gordon Research Conference on Post-Transcriptional Gene Regulation. Newry, ME, États-Unis
• B. Chabot. (2018). Splicing factors as targets in colorectal cancer. SPLICING 2018. Caparica, Portugal
• J. Barbier*, A. Cloutier*. (2018). Transient depletions of RNPS1 lead to perdurable changes in alternative splicing. CSH Asia RNA Biology. Suzhou, Chine
• B. Chabot. (2017). Alternative Splicing Modulation by Small Molecules. Seminar program at PTC Therapeutics. South Plainfield, États-Unis
• B. Chabot. (2017). Panel member on Splicing Discovery. 40 years of mRNA Splicing Cold Spring Harbor Laboratory Meeting. Cold Spring Harbor, États-Unis
• B. Chabot. (2017). Reconfiguration de l’épissage alternatif par les dommages à l’ADN. Conférence du CRCHUM - Cancer. Montréal, Canada
• B. Chabot. (2017). SRSF10, hnRNP A1, Sam68 and the RNA splicing response to DNA damage. Séminaire IGBMC. Montpellier, France
• B. Chabot. (2016). Connecting DNA damage with splicing decisions. Splicing 2016. Portugal
• Chabot, B., Blanchette, M., Story, B.A., Manley, J.L. Grierson, D.S. and Shkreta, L. (2016). The RNA splicing response to DNA damage is connected to the activity of SRSF10. 21st Annual Meeting of the RNA Society. Kyoto, Japon
• B. Chabot. (2015). A novel compound blocks HIV-1 replication by altering the function of the splicing regulator SRSF10. RNA and disease. Marrakech, Maroc
• B. Chabot. (2015). Connecting DNA damage to the alternative splicing of apoptotic and DNA repair genes. 16th Annual Meeting of the RiboClub. Orford, Canada
• B. Chabot. (2015). Connecting DNA damage with splicing decisions. Guest speaker. Toronto, Canada
• B. Chabot. (2014). Night watchmen with a day job: EJC components that control alternative splicing in cancer cells. 12th International Conference of the Pakistan Society of Biochemistry and Molecular Biology. Bahawalpur, Pakistan
• B. Chabot. (2013). Alternative splicing under stress and during cancer. Department of Biochemistry, McGill University. Montreal, Canada
• B. Chabot. (2013). Alternative splicing under stress and during cancer. University of British Columbia, Pharmaceutical Sciences. Vancouver, Canada
• B. Chabot. (2013). Alternative splicing under stress and during cancer. Advanced Medical Research Institute of Canada (AMRIC). Sudbury, Canada
• B. Chabot. (2013). Alternative splicing under stress and during cancer. Institut de cardiologie de Montréal. Montreal, Canada
• B. Chabot. (2013). Mechanisms of alternative splicing regulation during stress and human diseases. 56th Annual Conference of the Canadian Society for Molecular Biosciences. Niagara-on-the-Lake, Canada
• (2012). Alternative splicing under stress and during cancer. University of Manitoba - Dept. Physiology. Winnipeg, Canada
• (2012). Alternative splicing under stress and during cancer. Gene Center Colloquium - Hunter College of the City University of New York. New York, États-Unis
• (2012). Épissage alternatif et cancer. Centre de recherche sur le Cancer. Quebec, Canada
• (2011). Diversify and unite: regulating Bcl-x splicing during stress. "Gene expression and RNA processing" ICGEB meeting. Iguazu, Argentine
• (2011). Playing with introns : alternative usage in mammals and a vanishing act in yeast. Ribo-West 2011 UNBC. Prince-George, Canada
• (2011). Playing with introns : alternative usage in mammals and a vanishing act in yeast. Donnely Centre, University of Toronto. Toronto, Canada
• (2010). Cancer-specific alternative splicing. University of Western Ontario. London, Canada