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Abdelouahed Khalil

Professeur, Faculté de médecine et des sciences de la santé

FMSS Département de médecine

Présentation

Sujet de recherche

Athérosclérose, Maladies cardiovasculaires

Disciplines de recherche

Biochimie, Physiologie

Mots-clés

Biochimie des lipides, Transport inverse du cholestérol, HPLC et GC/MS, antioxydants, Paraoxonase, Maladies cardio-vasculaires, Vieillissement

Intérêts de recherche

Our research interests focus on the importance of the functionality of HDL in cardiovascular protection. In particular, we are interested in antioxidant and anti-inflammatory properties of HDL as well as their ability to mediate reverse cholesterol transport in the prevention of CVD. We aim to elucidate the mechanisms regulating these activities of HDL and determine proteins that are involved. We specifically targeting the paraoxonase (PON1), a protein associated exclusively with HDL and appears to play an important role in the regulation of the atheroprotective functions of HDL.

Centre de recherche

Centre de recherche sur le vieillissement du CIUSSS de l’Estrie – CHUS

Langues parlées et écrites

Anglais, Français

Diplômes

(1999). (Postdoctorat, Stage post-doctoral). Université de Sherbrooke.

(1995). (Doctorat, Doctorat es sciences). Université René Descartes (Paris V).

(1991). (Équivalent de la maîtrise, DEA - Maîtrise). Université René Descartes (Paris V).

(1989). (Baccalauréat, Maîtrise). Université Hassan II.

Prix et distinctions

  • (2007) Bourse Junior II du FRSQ. Fonds de recherche du Québec - Santé (FRQS). (Distinction).
  • (2003) Bourse Junior I du FRSQ. Fonds de recherche du Québec - Santé (FRQS). (Distinction).
  • (1999) Bourse Post-doc du FRSQ. Fonds de recherche du Québec - Santé (FRQS). (Distinction).
  • (1997) Bourse de l'OTAN- Ecole d'été sur le stress oxydatif. Organisation du traité de l'atlantique Nord. (Distinction).
  • Prix Maurice Louis Gérard. Académie de médecine. (Distinction).

Financement

  • (En cours d’évaluation). Candidat principal. La tomographie d'émission par positron pour la mesure de la fragilité de la plaque athérosclérotique et dans la stratification du niveau de risque cardiovasculaire. Instituts de Recherche en Santé du Canada (IRSC). Subvention projet. 1 050 000 $. (2021-2026)
  • (En cours d’évaluation). Cochercheur. Role de la taurine dans la prévention de la nécrose, l'hypertrophie et la défaillance cardiaque.. Instituts de Recherche en Santé du Canada (IRSC). Subvention Projet. 800 000 $. (2021-2026)
  • (Obtenu). Cochercheur. The COVID-19 Quebec long-term follow-up of high-risk survivors of COVID19. Pfizer's COVID-19 Competitive Grant Program. Programm Covid-19. 350 000 $. (2020-2022)
  • (Obtenu). Cochercheur. Assessing the clinical stages of Alzheimer's disease: identification of molecular biomarkers in blood cells.. Centre de recherche sur le vieillissement de l'IUGS. Programme d'initiatives stratégiques. 20 000 $. (2021-2022)
  • Subvention. (Terminé). Chercheur principal. Peut-on utiliser un seul biomarqueur pour l’évaluation du risque de survenue de l’infarctus du myocarde de chez la personne âgée? L’exemple de la troponine à haute sensibilité. Centre de recherche sur le vieillissement de l'IUGS. Programmes des Initiatives stratégiques. 20 000 $. (2019-2020)
  • Subvention. (Terminé). Chercheur principal. A three-dimentional (3D) brain model for unraveling the cellular and molecular mechanisms of the Alzheimer disease. Centre de recherche sur le vieillissement. Programme stratégiques. 62 500 $. (2016-2018)

Publications

Articles de revue

  • Benchagra L., Khalil A., Islam O., Ramchoun M., Boulbaroud S., Hajjaji A., Fülöp T., Ferreti G., Berrougui H. and Khalil A. (2021). Antioxidant effect of Moroccan pomegranate (Punica granatum L. Sefri variety) extracts rich in punicalagin against the oxidative stress process. Antioxidant 999 (99), (Article soumis).
  • Al-enezi M.S., Khalil A., Fulop T., Turcotte E, Bentourkia M. (2021). Assessment of inflammation in non-calcified artery plaques with dynamic 18F-FDG-PET/CT: CT alone, does-it detect the vulnerable plaque?. The International Journal of Cardiovascular Imaging 999 (99), (Article soumis).
  • *Sedighi SM, Fülöp T, Mohammadpour A, Nguyen M, Prud'homme P, Khalil A. (2021). Elevated cardiac troponin levels in geriatric patients without ACS: role of comorbidities. Canadian Journal of Cardiology Open 3 (3), 248-255. (Article publié).
  • *Otrante A; Trigui A;Walha R; Berrougui H; Fülöp T; Khalil A. (2021). Extra virgin olive oil prevents the age-related shifts of the distribution of HDL subclasses and improves their functionality. Nutrients 13 (7), 2235. (Article publié).
  • *Munawara U, Catanzaro M, Xu W, Tan C, Hirokawa K, Bosco N, Dumoulin D, Khalil A, Larbi A, Lévesque S, Ramassamy C, Barron AE, Cunnane SC., Beauregard PB, Bellenger J-P, Rodrigues S, Desroches M, Witkowski JM, Laurent B, Frost ÉH, Fülöp T. (2021). Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease. Immunity and Aging 18(1) (29), 10.1186/s12979-021-0. (Article publié).
  • T. Fulop, A. Larbi, G. Pawelec, A. Khalil, AA. Cohen, K. Hirokawa, J Witkowski, C. Franceschi. (2021). Immunology of aging: the birth of inflammaging. Critical Reviews in Allergy and Immunology 99 (9), 9. (Article soumis).
  • Fulop T, Rodrigues S, DesrochesM, Bunt T, Eiser A, Bernier F, Beauregard P, Barron A, Khalil A, Hirokawa K, Larbi A, Laurent B, Frost E, Witkowski JM. (2021). Targeting impaired antimicrobial immunity in the brain for the treatment of Alzheimer's disease. Neuropsychiatric disease and treatment 2021 (17), 1311-1339. (Article publié).
  • *Simo OK, Berrougui H, Fülöp T, Khalil A. (2021). The susceptibility to diet-induced atherosclerosis is exacerbated with aging in C57B1/6 mice. Biomedicines 9 (5), 487. (Article publié).
  • Andersen PL*, Vermette P, Khalil A, Fülöp T. (2020). Characterization of three-dimensional rat central nervous system culture maturation with applications to monitor cholinergic integrity. Biotechnology Progress 36 (4), e2976. (Article publié).
  • Outlioua, A*., Badre W., Desterke C., Echarki Z., El Hammani N., Rabhi M., Riyad M., Karkouri M., Arnoult D., Khalil, A., Akarid K. (2020). Gastric IL-1beta, IL-8, and IL-17A expression in Moroccan patients infected with Helicobacter pylori may be a predictive signature of severe pathological stages. Cytokine 126 154893. (Article publié).
  • Nagba Yendoubé Gbandjaba, Noreddine Ghalim, Rachid Saile, Abdelouahed Khalil. (2020). Journal of Molecular Biomarkers & Diagnosis. 7th International Conference and Expo on Molecular & Cancer Biomarkers JRS111 (111), 11. (Article publié).
  • Khalil A, Fulop T, Berrougui H. (2020). Role of paraoxonase1 in the regulation of HDL functionality and in cardiovascular protection. Antioxidants & Redox Signaling 34 (3), 191-200. (Article publié).
  • Fülöp T, Munawara U, Larbi A, Desroches M, Rodrigues S, Catanzaro M, Guidolin A, Khalil A, Bernier F, Barron AE, Hirokawa K, Beauregard PB, Dumoulin D, Bellenger J-P, Witkowski JM, Frost É. (2020). Targeting infectious agents as a therapeutic strategy in Alzheimer's disease. CNS Drugs 34 (7), 673-695. (Article publié).
  • Sedighi SM*, Nguyen M, Khalil A, Fulop T. (2020). The impact of cardiac troponin in elderly patients in the absence of acute coronary syndrome: A systematic review. IJC Heart & Vasculature 31 100629. (Article publié).
  • Tamas Fulop, Anis Larbi, Abdelouahed Khalil, Alan A. Cohen and Jacek M. Witkowski. (2019). Are we ill because we Age ?. Frontiers in Physiology 10.3389 .01508. (Article publié).
  • Mamdouh S.Al enezi, Reda Alla Abdo, Mohammed Yazid Mokeddem, Faiçcal A. Slimani, Abdelouahed Khalil, Tamas Fulop, Eric Turcote, M'hamed Bentourkia. (2019). Assessment of artery calcification in atherosclerosis with dynamic 18F-FDG-PET/CT imaging in elderly subjects. The International Journal of Cardiovascular Imaging ttps://doi.org/10.10 019-01527-7. (Article publié).
  • Tamas Fulop, Jacek M. Witkowski, Anis Larbi, Abdelouahed Khalil, Georges Herbein, Eric H. Frost. (2019). Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer’s disease?. Journal of NeuroVirology 25 (5), 634-647. (Article publié).
  • Boutros G., Jacob K. J., Fulop T., Khalil A., Dionne I.J., Tessier D., Trutschnigg B., Kilgour R.D., Vigano A. Morais J. A.,. (2019). Energy utilization and fatigue in frail older women in relation to walking. Advances in Geriatric Medicine and Research e190013. 1:. (Article publié).
  • Mahdi Sedighi S*, Prud’Homme P., Ghachem A., Lepage S, Nguyen M., Fulop F., Khalil A. (2019). High-sensitivity Cardiac Troponin T does not increase with age: the results of a retrospective study. International Journal of Cardiology Heart & Vasculature 22 187-191. (Article publié).
  • Aurelie Lepage, Abdelouahed Khalil, Patrick Vermette, Eric H. Frost, Jack M. Witkowski, tamas Fulop. (2019). The role of Elastin-derived Peptides in Human Physiology and Diseases. Matrix Biology 84 81-96. (Article publié).
  • Tamas Fulop, Jacek M. Witkowski, Karine Bourgade-Navarro, Abdelouahed Khalil, Echarki Zerif, Anis Larbi, Katsuiku Hirokawa, Graham Pawelec, Christian Bocti, Guy Lacombe, Gilles Dupuis, Eric H. Frost. (2018). Can an infection hypothesis explain the beta amyloid hypothesis of Alzheimer’s disease?. Frontiers Aging Neuroscience 10;224 (2018.00224), eCollection 201. (Article publié).
  • Gbandjaba N. Y.*, Boyode P., Kpegba K. and Khalil A. (2018). The Free Radical Theory of Ageing: Where are We 60 Years Later?. Gerontology & Geriatric studies 1 (5), GGS.000524. (Article publié).
  • Kamtcheung O. S.*, Souade I*, Berrouigui H., Khalil A. (2017). Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages. Canadian Journal of Physiology and Pharmacology 95 (8), 977-984. (Article publié).
  • Camponova P.* , Le Page A., Berrougui H., Lamoureux J., Pawelec G, Witkowski J.M., Fulop T, Khalil A. (2017). Alteration of the HDL functionality in Alzheimer disease patients. Canadian Journal of Physiology and Phramcaology 95 (8), 894-903. (Article publié).
  • Ikhlef Souade*, Berrougui Hicham*, Kamtchueng Olivier Simo*, Zerif Echerki, Khalil Abdelouahed. (2017). Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport. PLoS One 9 (13), e0173385. (Article publié).
  • Khalil Abdelouahed, Kamatchueng Simo Olivier*, Ikhlef Souade*, Berrougui Hicham. (2017). The role of paraoxonase 1 in regulating HDL functionality during aging. Canadian Journal of Physiology and Pharmacology 95 (10), 1254-1262. (Article publié).
  • Abdelghani Bounafaa*, Hicham Berrougui*, Boubker Nasser, Abdallah Bagri, Abderrahmane Moujahid, Noreddine Ghalim, Souad Ikhlef, Pamela Camponova*, Najoua Yamoul, Abdelkhalid Essamadi, Abdelouahed Khalil,. (2016). Association between paraoxonase 1 (PON1) polymorphisms and the risk of acute coronary syndrome in North African population. PLOS ONE 10 (8), e0133719. (Article publié).
  • Hicham Berrougui*, Souade Ikhlef*, Abdelouahed Khalil. (2016). Extra-virgin olive oil phenols, promotes cholesterol efflux and improves HDL functionality. Evidence-Based Complementary and Alternative Medicine 10.1155/2015 (10.1155/20), 208062. (Article publié).
  • Souad Ikhle*, Hicham Berrougui, Olivier Simo Kamptchueng*, Echarki Zerif,cAbdelouahed Khalil. (2016). Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport. PLOS ONE 12 ((3)), :e0173385. (Article publié).
  • S Ikhlef*, H Berrougui, A Khalil. (2016). Paraoxonase 1-treated oxLDL promotes cholesterol efflux from macrophages by stimulating PPRAgamma-LRX alpha-ABCA1 pathways. FEBS Letters 590 (11), 1614-1629. (Article publié).
  • A. Bounafaa*, H. Berrougui *, S. Ikhlef*, A. Essamadi, B. Nasser, A. Bennis, N. Yamoul, N. Ghalim, A. Khalil. (2014). Alteration of HDL functionality and PON1 activities in acute coronary syndrome patients. Clinical Biochemistry 47 318-325. (Article publié).
  • Anis Larbi, Fortin Carl, Gilles Dupuis, Hicham Berrougui, Abdelouahed Khalil, Tamas Fulop. (2014). Immunomodulatory Role of High Density Lipoproteins: Impact on Immunosenescence. Age 36 (5), 97-12. (Article publié).
  • Khalil A, Orellana MR*, Fulop T, Turcotte EE, Bentourkia M. (2014). Positron emission tomography imaging for vascular inflammation evaluation in elderly subjects with different risk factors for cardiovascular diseases. Am J Nucl Med Mol Imaging 4 (3), 283-292. (Article publié).
  • Orellana MR*, Bentourkia M, Sarrhini O, Fulop T, Paquet N, Lavallée E, Turcotte E, Khalil A. (2013). Assessment of inflammation in large arteries with 18F-FDG-PET in elderly. Comput Med Imaging Graph. 37 (7-8), 459-65. (Article publié).
  • Said T*, Tremblay-Mercier J, Berrougui H, Rat P, Khalil A. (2013). Effects of vegetable oils on biochemical and biophysical properties of membrane retinal pigment epithelium cells. Can J Physiol Pharmacol. 91 (10), 812-7. (Article publié).
  • Helal O* , Berrougui H* , Loued S* , Khalil A. (2013). Extra-virgin olive oil consumption improves the capacity of HDL to mediate cholesterol efflux and increases ABCA1 and ABCG1 expression in human macrophages. The British journal of nutrition 109 (10), 1844-55. (Article publié).
  • Loued S* , Berrougui H*, Componova P*, Ikhlef S*, Helal O* , Khalil A. (2013). Extra-virgin olive oil consumption reduces the age-related decrease in HDL and paraoxonase 1 anti-inflammatory activities. The British journal of nutrition 110 (7), 1272-84. (Article publié).
  • Nagba Yendoubé Gbandjaba*, Halima Labrazi, Abdelouahed Khalil, Rachid Saile, Nourddine Ghalim. (2013). Paraoxonase 1, un nouveau facteur de risque cardiovasculaire chez les diabétiques et les hémodialyses. European Journal of Scientific Research 112 394-407. (Article publié).
  • Berrougui H* , Momo CN* , Khalil A. (2012). Health benefits of high-density lipoproteins in preventing cardiovascular diseases. Journal of clinical lipidology 6 (6), 524-33. (Article publié).
  • Khalil A. Berrougui H* , Pawelec G , Fulop T. (2012). Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease. Mechanisms of ageing and development 133 (1), 20-9. (Article publié).
  • Morais JA , Wollin S , Khalil A , Gray-Donald K , Feine JS. (2012). Implant overdentures and nutrition: a randomized controlled trial. Journal of dental research 91 (1), 39-46. (Article publié).
  • Gbandjaba NY*,Ghalim N , Hassar M , Berrougui H , Labrazi H , Taki H , Saile R , Khalil A. (2012). Paraoxonase activity in healthy, diabetic, and hemodialysis patients. Clinical biochemistry 45 (6), 470-4. (Article publié).
  • Berrougui H*. Loued S* , Khalil A. (2012). Purified human paraoxonase-1 interacts with plasma membrane lipid rafts and mediates cholesterol efflux from macrophages. Free radical biology & medicine 52 (8), 1372-81. (Article publié).
  • Loued S*, Isabelle M* , Berrougui H* , Khalil A. (2012). The anti-inflammatory effect of paraoxonase 1 against oxidized lipids depends on its association with high density lipoproteins. Life sciences 90 (1-2), 82-8. (Article publié).
  • Khalil A , Larbi A. (2012). The role of elastin peptides in modulating the immune response in aging and age-related diseases. Pathologie-biologie 60 (1), 28-33. (Article publié).
  • Meesat R* , Sanguanmith S , Meesungnoen J , Lepage M , Khalil A , Jay-Gerin JP. (2012). Utilization of the ferrous sulfate (Fricke) dosimeter for evaluating the radioprotective potential of cystamine: experiment and Monte Carlo simulation. Radiation research 177 (6), 813-26. (Article publié).
  • Khalil A , Gaudreau P , Cherki M* , Wagner R , Tessier DM , Fulop T , Shatenstein B. (2011). Antioxidant-rich food intakes and their association with blood total antioxidant status and vitamin C and E levels in community-dwelling seniors from the Quebec longitudinal study NuAge. Experimental gerontology 46 (6), 475-81. (Article publié).
  • Labonte M* , Dionne IJ , Khalil A. (2011). Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population. The journal of nutrition, health & aging 15 (10), 883-9. (Article publié).
  • Labonté M* , Khalil A , Dionne IJ. (2010). Effects of resistance training combined with antioxidant supplementation on fat-free mass and insulin sensitivity in healthy elderly subjects. Diabetes research and clinical practice 87 (1), e1-3. (Article publié).
  • Aubertin-Leheudre M* , Lord C , Labonté M , Khalil A , Dionne IJ. (2010). Fat mass threshold associated with a significant deterioration of insulin sensitivity in postmenopausal women. Diabetes research and clinical practice 88 (1), e1-3. (Article publié).
  • R. Messat*, J-F. Allard, D. Houde, L. Tremblay, A. Khalil, J-p" Jay Gerin, M. Lepage. (2010). Femtosecond laser pulse filamentation characterized by polymer dosimetry and Fricke dosimetry Journal of Physics: Conference Series. Journal of Physics: Conference Series 250 385-389. (Article publié).
  • H Berrougui and A Khalil. (2009). Age-associated decrease of HDL-mediated reverse cholesterol transport activity. Rejuvenation Research 12 (2), 117-26. (Article publié).
  • Khalil A. (2009). Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity. Rejuvenation research 12 (2), 117-26. (Article publié).
  • Grenier G , Loued S , Drouin G , Khalil A. (2009). A new insight into resveratrol as an atheroprotective compound: inhibition of lipid peroxidation and enhancement of cholesterol efflux. Atherosclerosis 207 (2), 420-7. (Article publié).
  • Labonté M , Tessier D , Khalil A , Bobeuf F , Doyon CY , Rieth N , Dionne IJ. (2009). Effect of antioxidants combined to resistance training on BMD in elderly women: a pilot study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20 (7), 1253-8. (Article publié).
  • Bobeuf F , Labonté M , Khalil A , Dionne IJ. (2009). Effect of resistance training on hematological blood markers in older men and women: a pilot study. Current gerontology and geriatrics research 2009 (13), 156820. (Article publié).
  • Tessier DM , Khalil A , Trottier L , Fülöp T. (2009). Effects of vitamin C supplementation on antioxidants and lipid peroxidation markers in elderly subjects with type 2 diabetes. Archives of gerontology and geriatrics 48 (1), 67-72. (Article publié).
  • Meesat R , Jay-Gerin JP , Khalil A , Lepage M. (2009). Evaluation of the dose enhancement of iodinated compounds by polyacrylamide gel dosimetry. Physics in medicine and biology 54 (19), 5909-17. (Article publié).
  • Hassaine A , Dionne IJ , Gaudreau P , Khalil A , Fulop T , Shatenstein B , Tessier D , Morais JA. (2009). Frailty in the elderly is associated with insulin resistance of glucose metabolism in the postabsorptive state only in the presence of increased abdominal fat. Experimental gerontology 44 (11), 740-4. (Article publié).
  • A Khalil & H Berrougui. (2009). Mechanism of action of resveratrol in lipid metabolism and atherosclerosis, Editorial. Journal of Clinical Lipidology 4 (5), 527-531. (Article publié).
  • Labonté M , Dionne IJ , Bouchard DR , Sénéchal M , Tessier D , Khalil A , Labonté M , Bobeuf F , Tessier D , Khalil A , Dionne IJ. (2008). Effects of antioxidant supplements combined with resistance exercise on gains in fat-free mass in healthy elderly subjects: a pilot study. Journal of the American Geriatrics Society 56 (9), 1766-8. (Article publié).
  • Dionne IJ , Bouchard DR , Sénéchal M , Tessier D , Khalil A , Labonté M , Bobeuf F , Tessier D , Khalil A , Dionne IJ. (2008). Effects of antioxidant supplements combined with resistance exercise on gains in fat-free mass in healthy elderly subjects: a pilot study. Journal of the American Geriatrics Society 56 (9), (Article publié).
  • Lord C , Khalil A , Dionne IJ. (2008). Isoflavones and clinical cardiovascular risk factors in obese postmenopausal women: a randomized double-blind placebo-controlled trial. Journal of women's health 17 (8), 1363-9. (Article publié).
  • Aubertin-Leheudre M , Lord C , Khalil A , Dionne IJ. (2008). Isoflavones and clinical cardiovascular risk factors in obese postmenopausal women: a randomized double-blind placebo-controlled trial. Journal of women's health (2002) 17 (8), (Article publié).
  • Grenier G , Khalil A , Vermette P. (2008). Oxidized-LDL induce morphological changes and increase stiffness of endothelial cells. Experimental cell research 314 (16), (Article publié).
  • Aubertin-Leheudre M , Lord C , Labonté M , Khalil A , Dionne IJ. (2008). Relationship between sarcopenia and fracture risks in obese postmenopausal women. Journal of women & aging 20 (3-4), (Article publié).
  • Aubertin-Leheudre M , Lord C , Labonté M , Khalil A , Dionne IJ. (2008). Relationship between sarcopenia and fracture risks in obese postmenopausal women. Journal of women & aging 20 (3-4), (Article publié).
  • Isabelle M , Cloutier M , Grenier G , Khalil A. (2007). Age-related impairment of HDL-mediated cholesterol efflux. Journal of lipid research 48 (2), (Article publié).
  • Cherki M , Koumbadinga GA , Isabelle M , Douville J , Spino C , Khalil A. (2007). Antiatherogenic activity of extracts of Argania spinosa L. pericarp: beneficial effects on lipid peroxidation and cholesterol homeostasis. Canadian journal of physiology and pharmacology 85 (9), (Article publié).
  • Aubertin-Leheudre M , Lord C , Khalil A , Dionne IJ. (2007). Effect of 6 months of exercise and isoflavone supplementation on clinical cardiovascular risk factors in obese postmenopausal women: a randomized, double-blind study. Menopause (New York, N.Y.) 14 (4), (Article publié).
  • Berrougui H , Isabelle M , Cloutier M , Koumbadinga GA , Khalil A. (2007). Effect of PON1 polymorphism on HDL antioxidant potential is blunted with aging. Experimental gerontology 42 (8), (Article publié).
  • Lord C , Aubertin-Leheudre M , Dionne IJ , Khalil A , Tremblay A. (2007). Is overweight/obesity associated with short sleep duration in older women?. Aging clinical and experimental research 19 (4), (Article publié).
  • Chouinard JA , Khalil A , Vermette P. (2007). Method of imaging low density lipoproteins by atomic force microscopy. Microscopy research and technique 70 (10), (Article publié).
  • Gaudreau P , Morais JA , Shatenstein B , Gray-Donald K , Khalil A , Dionne I , Ferland G , Fülöp T , Jacques D , Kergoat MJ , Tessier D , Wagner R , Payette H. (2007). Nutrition as a determinant of successful aging: description of the Quebec longitudinal study Nuage and results from cross-sectional pilot studies. Rejuvenation research 10 (3), (Article publié).
  • Chaput JP , Lord C , Cloutier M , Aubertin Leheudre M , Goulet ED , Rousseau S , Khalil A , Dionne IJ. (2007). Relationship between antioxidant intakes and class I sarcopenia in elderly men and women. The journal of nutrition, health & aging 11 (4), (Article publié).
  • Aubertin-Leheudre M , Lord C , Khalil A , Dionne IJ. (2007). Six months of isoflavone supplement increases fat-free mass in obese-sarcopenic postmenopausal women: a randomized double-blind controlled trial. European journal of clinical nutrition 61 (12), (Article publié).
  • de Guise C , Berrougui H , Cloutier M , Isabelle M , Fulop T , Payette H , Khalil A. (2006). Age-related decrease in high-density lipoproteins antioxidant activity is due to an alteration in the PON1's free sulfhydryl groups. Atherosclerosis 185 (1), (Article publié).
  • Cherki M , Berrougui H , Drissi A , Adlouni A , Khalil A. (2006). Argan oil: which benefits on cardiovascular diseases?. Pharmacological research : the official journal of the Italian Pharmacological Society 54 (1), (Article publié).
  • Dupuis G , Khalil A , Douziech N , Fortin C , Fülöp T. (2006). Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging. Cellular signalling 18 (7), (Article publié).
  • Aubertin-Leheudre M , Lord C , Goulet ED , Khalil A , Dionne IJ. (2006). Effect of sarcopenia on cardiovascular disease risk factors in obese postmenopausal women. Obesity (Silver Spring, Md.) 14 (12), (Article publié).
  • Berrougui H , Isabelle M , Cherki M , Khalil A. (2006). Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage. Life sciences 80 (2), (Article publié).
  • Cloutier M , Isabelle M , Khalil A. (2006). Phenolic-extract from argan oil (Argania spinosa L.) inhibits human low-density lipoprotein (LDL) oxidation and enhances cholesterol efflux from human THP-1 macrophages. Atherosclerosis 184 (2), 389-96. (Article publié).
  • Berrougui H , Isabelle M , Cloutier M , Hmamouchi M , Khalil A. (2006). Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation. The Journal of pharmacy and pharmacology 58 (7), (Article publié).
  • Isabelle M , Cloutier M , Hmamouchi M , Khalil A. (2006). Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation. The Journal of pharmacy and pharmacology 58 (7), (Article publié).
  • Berrougui H , Martín-Cordero C , Khalil A , Hmamouchi M , Ettaib A , Marhuenda E , Herrera MD. (2006). Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta. Pharmacological research : the official journal of the Italian Pharmacological Society 54 (2), (Article publié).
  • Cherki M , Derouiche A , Drissi A , El Messal M , Bamou Y , Idrissi-Ouadghiri A , Khalil A , Adlouni A. (2005). Consumption of argan oil may have an antiatherogenic effect by improving paraoxonase activities and antioxidant status: Intervention study in healthy men. Nutrition, metabolism, and cardiovascular diseases : NMCD 15 (5), (Article publié).
  • Larbi A , Fortun A , Robert L , Khalil A. (2005). Elastin peptides induced oxidation of LDL by phagocytic cells. Pathologie-biologie 53 (7), (Article publié).
  • Larbi A , Douziech N , Dupuis G , Khalil A , Pelletier H , Guerard KP , Fülöp T. (2004). Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes. Journal of leukocyte biology 75 (2), (Article publié).
  • Douziech N , Khalil A , Dupuis G , Gheraïri S , Guérard KP , Fülöp T. (2004). Effects of methyl-beta-cyclodextrin on T lymphocytes lipid rafts with aging. Experimental gerontology 39 (4), (Article publié).
  • Dupuis G , Douziech N , Khalil A , Fülöp T. (2004). Low-grade inflammation with aging has consequences for T-lymphocyte signaling. Annals of the New York Academy of Sciences 1030 (52), (Article publié).
  • Fulop T , Larbi A , Douziech N , Fortin C , Guérard KP , Lesur O , Khalil A , Dupuis G. (2004). Signal transduction and functional changes in neutrophils with aging. Aging cell 3 (4), (Article publié).
  • Seres I , Paragh G , Deschene E , Fulop T , Khalil A. (2004). Study of factors influencing the decreased HDL associated PON1 activity with aging. Experimental gerontology 39 (1), (Article publié).
  • Shatenstein B , Payette H , Nadon S , Gray-Donald K ,. (2003). An approach for evaluating lifelong intakes of functional foods in elderly people. The Journal of nutrition 133 (7), (Article publié).
  • Milochevitch C , Khalil A. (2003). PON1 paraoxonase activity is reduced during HDL oxidation and is an indicator of HDL antioxidant capacity. Free radical research 37 (1), (Article publié).
  • Khalil, A. (2002). [Molecular mechanisms of the protective effect of vitamin e against atherosclerosis]. Canadian journal of physiology and pharmacology 80 (7), (Article publié).
  • Khalil A , Fülöp T. (2001). A comparison of the kinetics of low-density lipoprotein oxidation induced by copper or by gamma-rays: influence of radiation dose-rate and copper concentration. Canadian journal of physiology and pharmacology 79 (2), (Article publié).
  • Khalil A , Gagné D , Douziech N , Kuntz C , Jay-Gerin JP , Dupuis G , Fülöp T. (2001). Monocytes influence the fate of T cells challenged with oxidised low density lipoproteins towards apoptosis or MHC-restricted proliferation. Atherosclerosis 156 (1), (Article publié).
  • Milochevitch C , Khalil A. (2001). Study of the paraoxonase and platelet-activating factor acetylhydrolase activities with aging. Prostaglandins, leukotrienes, and essential fatty acids 65 (5-6), (Article publié).
  • Fortin JP , LeHoux JG , Fülöp T. (2000). Age-related decrease of dehydroepiandrosterone concentrations in low density lipoproteins and its role in the susceptibility of low density lipoproteins to lipid peroxidation. Journal of lipid research 41 (10), (Article publié).
  • Khalil A , Fülöp T. (1999). Effects of an oral glucose challenge on free radicals/antioxidants balance in an older population with type II diabetes. The journals of gerontology. Series A, Biological sciences and medical sciences 54 (11), (Article publié).
  • Maheux P , Khalil A , Fülöp T. (1999). Effects of gliclazide versus metformin on the clinical profile and lipid peroxidation markers in type 2 diabetes. Metabolism: clinical and experimental 48 (7), (Article publié).
  • Wagner JR , Khalil A , Weber J , Trottier L , Payette H. (1999). Relationship between the response to influenza vaccination and the nutritional status in institutionalized elderly subjects. The journals of gerontology. Series A, Biological sciences and medical sciences 54 (2), (Article publié).
  • Jay-Gerin JP , Fülöp T. (1998). Age-related increased susceptibility of high-density lipoproteins (HDL) to in vitro oxidation induced by gamma-radiolysis of water. FEBS letters 435 (2-3), (Article publié).
  • Jacob MP , Khalil A , Wallach J , Robert L. (1998). Biological effects of elastin peptides. Pathologie-biologie 46 (7), (Article publié).
  • Lehoux JG , Wagner RJ , Lesur O , Cruz S , Dupont E , Jay-Gerin JP , Wallach J , Fülöp T. (1998). Dehydroepiandrosterone protects low density lipoproteins against peroxidation by free radicals produced by gamma-radiolysis of ethanol-water mixtures. Atherosclerosis 136 (1), (Article publié).
  • Khalil A , Fortun A , Hébert S , Jay-Gerin JP , El Abbouyi A , Wallach J , Fülöp T. (1998). Novel 21-aminosteroid U-74389G inhibits low-density lipoprotein peroxidation induced by .OH and O2-. free radicals. Life sciences 63 (9), (Article publié).
  • Fouquet C , Allaire P , Perrin N , Lacombe G , Stankova J , Rola-Pleszczynski M , Gagné D , Wagner JR , Khalil A , Dupuis G. (1997). Changes in apoptosis of human polymorphonuclear granulocytes with aging. Mechanisms of ageing and development 96 (1-3), (Article publié).
  • Khalil A , Delattre J , Jore D , Gardès-Albert M. (1997). Oxidation of human high-density lipoproteins by .OH and .OH/O(.-)2 free radicals. Radiation research 147 (6), (Article publié).
  • Bonnefont-Rousselot D , Khalil A , Gardès-Albert M , Delattre J. (1997). Reciprocal protection of LDL and HDL oxidised by .OH free radicals in the presence of oxygen. FEBS letters 403 (1), (Article publié).
  • Wagner JR , Lacombe G , Dangoisse V , Fülöp T. (1996). Increased susceptibility of low-density lipoprotein (LDL) to oxidation by gamma-radiolysis with age. FEBS letters 392 (1), (Article publié).
  • Motta C , Khalil AO , Sola R , La Ville AE , Delattre J , Gardès-Albert M. (1995). Physicochemical changes in human high-density lipoproteins (HDL) oxidized by gamma radiolysis-generated oxyradicals. Effect on their cholesterol effluxing capacity. Biochimica et biophysica acta 1255 (1), 23-30. (Article publié).
  • Delattre J , Bonnefont-Rousselot D , Khalil A , Lepage S , Gardes-Albert M , Ferradini C. (1993). [Peroxidation of human high density lipoproteins by oxygen-derived free radicals]. Bulletin de l'Académie nationale de médecine 177 (7), (Article publié).

Chapitres de livre

  • Hassiba Chebbihi, Anal Cohen, Tamas Fulop, Abdelouahed Khalil. (2021). Biologie du Vieillissement. Marcle Arcand et Réjean Hebert. Précis Pratique de gériatrie (4ème Édition). Canada : EDISEM. (Article sous presse).
  • Anis Larbi, Emilie Combet Aspray, Graham Pawelec, Abdelouahed Khalil, and Tamas Fulop. (2019). Effect of Intrinsic and Extrinsic Lipids on T-Cell Signaling. T. Fulop, C. Franceschi, K. Hirokawa, G. Pawelec. Handbook of Immunosenescence. Basic Understanding and Clinical Applications. 2nd: 1-18. (Springer Nature Switzerland AG 2018, T. Fulop et a, 2nd, 1-18.). Pays-Bas : Springer. (Article publié).

Articles de conférence

  • *Douhi A, Al-Enezi MS, Khalil A, Bentourkia MH. (2021). Évaluation des plaques d'athérosclérose par l'imagerie TEP/TDM chez des patients âgés. web, (Article publié).
  • Nousra Berrahmoune, Mamdouh S. Al-enezi, Abdelillah Douhi, Tamas Fulop, Eric Turcotte, M’hamed Bentourkia, Abdelouahed Khalil. (2020). the virtual 2020 IEEE Nuclear Science Symposium (NSS) and Medical Imaging Conference (MIC). (Article soumis).
  • *Berrahmoune N, *Alenezi M, Khalil A, Fülöp T, Turcotte É, Bentourkia M. (2020). Analyse de la plaque d’athérosclérose par l’imagerie métabolique et fonctionnelle chez les personnes âgées. Cahier des résumés, --. (Article publié).
  • *Douhi A, *Alenezi M, Khalil A, Fülöp T, Turcotte É, Bentourkia M. (2020). Diagnostique de l’athérosclérose par l’imagerie TEP/TDM des artères chez les personnes âgées. Cahier des résumés, --. (Article publié).
  • *Alenezi M, Khalil A, Fülöp T, Turcotte É, Bentourkia M. (2020). Estimation of inflammation of atherosclerosis in elderly with 18F-FDG using Two-tissue compartment model. Cahier des résumés, --. (Article publié).
  • *Alenezi M, Khalil A, Bentourkia M. (2019). Correlation of artery single and multi-spots calcifications with metabolism using FDG-PET/CT imaging in elderly with atherosclerosis. Cahier des résumés, --. (Article publié).
  • *Berrhamoune N, Al-Enezi MS, Khalil A, Fülöp T, Turcotte É, Bentourkia M. (2019). Imaging of atherosclerosis with dynamic PET/CT. Cahier des résumés, --. (Article publié).
  • *Al-Enezi M, Fülöp T, Turcotte E, Bentourkia M, Khalil A. (2019). Kinetic modeling of PET-18F-FDG in the human arteries with inflammation. Cahier des résumés, --. (Article publié).
  • Nguyen M, Lepage S, *Sedighi SM, *Ghachem A, Fülöp T, Prud'Homme P*, Khalil A. (2019). Revisiting the association between ageing and increased level of Troponin. Cahier des résumés, --. (Article publié).
  • *Al-enezi M, Khalil A, Bentourkia M. (2019). Targeted osteogenesis and calcificationusing sodium-fluoride PET-CT imaging in elderly with atherosclerosis. Cahier des résumés, --. (Article publié).
  • *Alenezi M, *Slimani Faiçal AA, Khalil A, Bentourkia M. (2017). Modeling and correlation between CT calcification and glucose metabolism in atherosclerosis. Cahier des résumés, --. (Article publié).
  • *Al-Enezi M, Bentourkia M, *Slimani Faiçal AA, Khalil A. (2016). Segmentation and kinetic modeling of human arteries in PET/CT imaging. Cahier des résumés, --. (Article publié).
  • Khalil Abdelouahed, Sarrhini Otman*, Fulop Tamas, Paquet Nancy, Lavallee Eric, Turcotte Eric, Bentourkia M'hamed. Assessment of glucose metabolism in atherosclerosis inflammation with FDG-PET. World Molecular Imaging Congress.
  • Rossibel Montesino Orellana Marlene*, Khalil Abdelouahed, Bentourkia M'hamed. Characterization of artery inflammation associated with aging using the PET imaging. Aging and Society: An Interdisciplinary Conference.
  • Rossibel Montesino Orellana Marlene*, Khalil Abdelouahed, Sarrhini Otman*, Fulop Tamas, Paquet Nancy, Lavallee Eric, Turcotte Eric, Bentourkia M'hamed. Repeated measurements of atherosclerosis in elderly patients with FDG-PET. World Molecular Imaging Congress.

Autres contributions

Présentations

  • Nousra Berrahmoune, Mamdouh S. Al-enezi, Abdelillah Douhi, Tamas Fulop, Eric Turcotte, M’hamed Bentourkia. (2020). Coupling of CT and PET-18F-FDG imaging in arteries with calcification. virtual 2020 IEEE Nuclear Science Symposium (NSS) and Medical Imaging Conference (MIC). États-Unis
  • Abdelouahed Khalil. (2019). Extra virgin olive oil reduces the age-related alteration of the HDL particle size and functionality. 2019 High Density Lipoprotein (HDL) Workshop. September 25-27. Valencia, Espagne
  • Olivier kamtchueng Simo, Souade Ikhlef, Hicham Berrougui , and Abdelouahed Khalil. (2018). HDL dans la régulation de l’homéostasie du cholestérol. 6e journée scientifique du DOCC (diabéte, obésité et complications cardiovasculaires). Sherbrooke, Canada
  • Olivier kamtchueng Simo, Souade Ikhlef, Hicham Berrougui , and Abdelouahed Khalil. (2018). Le D-galactose pour l’étude de l’effet de l’âge sur le transport inverse du cholestérol. la Société québécoise de lipidologie, de nutrition et de métabolisme (SQLNM), du Réseau de recherche en santé cardiométabolique, diabète et obésité (CMDO). Sherbrooke, Canada
  • Michel Nguyen, Serge Lepage, Seyed Mahdi Sedighi*, Ahmed Ghachem, Tamas Fulop, Patrick Prud’Homme, Abdelouahed Khalil. (2018). Revisiting the association between ageing and increased level of Troponin. European Society of Cardiology (ESC) Congress 2018. Allemagne
  • Olivier kamtchueng Simo, Souade Ikhlef, Hicham Berrougui , and Abdelouahed Khalil. (2017). 6- Effet athéroprotecteur des HDLs au cours du vieillissement. Association Francophone pour le savoir (ACFAS). Montréal, Canada
  • (2016). HDL FUNCTIONALITY, or HDL Quality versus HDL Quantity. 4th Cardiovascular Forum for Promoting Centres of Excellence and Young Investigators. Canada
  • N/A. (2016). Paraoxonase 1 (PON1) maintains cellular cholesterol homeostasis via the regulation of cholesterol efflux. 84th EAS Congress. Innsbruk, Autriche
  • Olivier Kamtchueng Simo. (2016). Paraoxonase 1-treated oxLDL promotes cholesterol efflux from macrophages by stimulating the PPAR Ƴ–LXRα–ABCA1pathway. 4th Forum to promote Young Investigators and Centers of Excellence In Cardiovascular Research. Sherbrooke, Canada
  • (2013). Consommation de l'huile d'olive et maladies cardiovasculaire chez la personne âgée. 6ème Journées Internationales d'Étude sur les Lipides. Casablanca, Maroc
  • (2013). Inflammation, cholesterol homeostasis and Paraoxonase 1 : Recents Advances and Potential for Antioxidants Applications. The 13th international Conference on Antioxidants. Marrakech, Maroc
  • (2012). Extra virgin olive oil consumption reduces the age-related increase of the atherosclerosis process. The 2nd Euro Mediterranean Conference on Bioengineering & Biomaterials. Fes, Maroc, Maroc
  • (2011). Athérosclérose et vieillissement : rôle de la paraoxonase1 dans la protection cardiovasculaire. Journée de recherche interdisciplinaire en santé. Moncton, Canada
  • (2010). La Tomographie par Émission de Positron et marquage au Fludeoxyglucose (18FDG) pour évaluer l’inflammation au niveau artériel. 4th International Meeting on Molecular Chemistry and Development “RICMD4’2010”. Marrakech, Maroc
  • (2010). Oxidative stress and age-related alterations of paraoxoanse 1 in the process of atherosclerosis. International Congress on controversies in longevity, Health and Aging. Barcelona, Espagne
  • (2010). Paraoxonase 1 et processus d'athérosclérose au cours du vieillissement. 9e Congrès International Francophone de Gérontologie et de Gériatrie (CIFGG). Nice, France