Présentation

Sujets de recherche

Cell Signaling, Hormones and Growth Factors, Gastrointestinal Pathologies, Cancer of the Digestive System, Immune Mediators: Cytokines and Chemokines, Crohn's Disease, Diabetes.

Disciplines de recherche

Cell Biology, Molecular Biology.

Mots-clés

animal models, cell biology, GI diseases, GPCR, inflammation, intestinal epithelium, ion channels, molecular biology, signal transduction, transcription factors.

Intérêts de recherche

Our interest is to understand the roles of the G protein-coupled P2Y receptors and the ionotropic P2X7 receptor in intestinal epithelium functions in GI diseases and colorectal cancer. More particularly, we focus at elucidating the epigenetic and molecular mechanisms regulating these receptors expression, at characterizing their signaling transduction pathways in epithelial cells and at determining how they modulate cross-talks between epithelial cells and immune cells.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

• (2005) Poster of distinction. World Congress of Gastroenterology. (Distinction).

Financement

Grant. (Awarded). Principal Applicant. Elucidating alternative leucine-rich G protein coupled receptor-5 (Lgr5) signaling.. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery grant. 160000 $ (2019-2024).

Grant. (Awarded). Principal Applicant. Development of novel IBD-modifying drugs by targeting purinergic receptors.. Crohn's & Colitis Foundation of Canada (CCFC). Grants-in-aid of Research. 375000 $ (2018-2021).

Grant. (Awarded). Co-applicant. Preclinical validation of humanized chicken recombinant antibodies targeting GPCRs overexpressed in cancers. Québec Consortium for Drug Discovery (CQDM). SynergiQC. 1100000 $ (2018-2020).

Grant. (Completed). Co-applicant. Chronic Inflammation, Immunity and Cancer (CIIC 2019). Canadian Association of Gastroenterology (The). CAG conference grant. 10000 $ (2019).

Grant. (Completed). Co-applicant. Chronic Inflammation, Immunity and Cancer 2019. Canadian Institutes of Health Research (CIHR). Planning and Dissemination Grant - Institute Community Support. 15000 $ (2019).

Grant. (Completed). Co-applicant. The Sherbrooke Personalized Colorectal Cancer Avatar Models Initiative (COLOR project).. Faculty of medicine and health sciences. Programme de subventions Merck Sharp & Dohme. 249960 $ (2016-2018).

Grant. (Completed). Principal Investigator. Characterization of the mechanism regulating P2X7 expression and function in intestinal epithelial cells. (2013-2018).

Grant. (Completed). Principal Investigator. Regulation and role of P2Y6 nucleotide receptor in colorectal cancer. (2013-2018).

Grant. (Completed). Co-investigator. A new generation of anti-GPCR antibodies for the diagnosis & treatment of colorectal cancer.. (2015-2017).

Grant. (Completed). Co-investigator. Histone deacetylases: epigenetic regulators of intestinal epithelial homeostasis. (2014-2017).

Grant. (Completed). Principal Applicant. High-throughput protein immunolocalization analysis through virtual fluorescence imaging.. (2015-2016).

Scholarship. (Completed). Principal Applicant. Rôle des récepteurs purinergiques P2 dans le maintien de l'homéostasie de l'épithelium intestinal.. (2013-2014).

Grant. (Completed). Co-investigator. Role of C/EBP transcription factors and deacetylation in intestinal inflammation. (2011-2014).

Grant. (Completed). Principal Investigator. Étude des mécanismes moléculaires et cellulaires impliqués dans les physiopathologies de l'épithélium intestinal.. (2008-2013).

Grant. (Completed). Co-applicant. CIHR Team on the digestive epithelium. (2007-2012).

Grant. (Completed). Principal Investigator. Role of epithelial cells P2Y receptors in the dysfunction of the intestinal mucosa during inflammation.. (2009-2012).

Grant. (Completed). Co-applicant. Corrélation inverse leucocytes BLTR1 et inflammation. (2011).

Grant. (Completed). Principal Investigator. Role of the P2X7 nucleotide receptors in intestinal epithelial cell proliferation and differentiation. (2006-2011).

Scholarship. (Completed). Principal Investigator. RÔLES DES RÉCEPTEURS NUCLÉOTIDIQUES P2 DES CELLULES ÉPITHÉLIALES DANS L'ORCHESTRATION DE LA RÉPONSE INFLAMMATOIRE DE LA MUQUEUSE INTESTINALE.. (2009-2010).

Grant. (Completed). Principal Investigator. Role of epithelial cells P2Y receptors in the dysfunction of the intestinal mucosa during inflammation.. (2009-2010).

Grant. (Completed). Principal Investigator. Role and function of the P2Y2 nucleotide receptor in the IEC inflammatory responses.. (2006-2009).

Grant. (Completed). Principal Investigator. Rôles et fonctions des récepteurs nucléotidiques P2 dans le développement et la progression des maladies inflammatoires de l'intestin.. (2006-2009).

Grant. (Completed). Principal Applicant. Étude des mécanismes moléculaires et cellulaires impliqués dans les physiopathologies de l'épithélium intestinal.. (2008-2009).

Fellowship. (Completed). Principal Investigator. Rôles et fonctions des récepteurs nucléotidiques P2 dans le développement et la progression des maladies inflammatoires de l'intestin.. (2006-2008).

Grant. (Completed). Principal Investigator. Rôles et fonctions des récepteurs nucléotidiques P2 dans le développement et la progression des maladies inflammatoires de l'intestin.. (2005-2007).

Fellowship. (Completed). Principal Applicant. Analysis of CDX2 role in intestinal differentiation. (2003-2005).

Fellowship. (Completed). Principal Applicant. Regulation and roles of P2 nucleotide receptors in neuroinflammation. (2000-2002).

Fellowship. (Completed). Principal Applicant. Rôle de l’ATP diphosphohydrolase dans le systeme circulatoire. (1999-2000).

Fellowship. (Completed). Principal Applicant. Rôle de l’ATP diphosphohydrolase dans le systeme circulatoire. (1998-1999).

Publications

Articles de revue

• Bergamin L, Penolazzi L, Lambertini E, Falzoni S, Sarti AC, Molle CM*, Gendron FP, De Bonis P, Di Virgilio F, Piva R. (2020). Expression and function of the P2X7 receptor in human osteoblasts: role of NFATc1 transcription factor. Journal of Cellular Physiology, xx(xx), xx. (Submitted).
• *Girard M, *Dagenais Bellefeuille S, *Eiselt É, *Morgane P, Arguin G, Longpré JM, Sarren P, Gendron FP. (2020). The P2Y6 receptor signals through Gαq/Ca2+/PKCα and Gα13/ROCK pathways to drive the formation of membrane protrusions and dictate cell migration. Journal of Cellular Physiology, xx(xx), xx. (Revision Requested).
• Molle CM*, Arguin G, Jemfer C*, Placet M*, Dagenais Bellefeuille S*, Gendron FP. (2020). The expression of the P2Y6 receptor is regulated at the transcriptional level by p53. Biochemical and Biophysical Research Communication, xx(xx), xx. (In Press).
• *Dagenais Bellefeuille S, *Molle CM, Gendron FP. (2019). Reviewing the role of P2Y receptors in specific gastrointestinal cancers. Purinergic Signalling, 15(4), 451-463. (Published).
• Zelikman V, Pelletier J, Simhaev L, Sela A, Gendron FP, Arguin G, Senderowitz H, Sévigny J, Fischer B. (2018). Highly Selective and Potent Ecto-nucleotide pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine-5'-P α,α-dithiophosphate Analogues. J Med Chem, 61(9), 3939-3951. (Published).
• *Placet M, Arguin G, *Molle CM, Babeu JP, Jones C,Carrier JC, Robaye B, Geha S, Boudreau F, Gendron FP. (2018). The G protein-coupled P2Y6 receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis. BBA - Molecular Basis of Disease, 1864(5 Pt A), 1539-1551. (Published).
• Arguin G, *Bourzac JF, *Placet M, *Molle CM, Paquette M, Beaudoin JF, Rousseau JA, Lecomte R, Plourde M, Gendron FP. (2017). The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Scientific Reports, 7(1), 12917. (Published).
• *Lepage D, *Bélanger E, Jones C, *Tremblay S, *Allaire J, Asselin C, Perreault N, Menendez A, Gendron FP, Boudreau F. (2016). Gata4 is critical to maintain functional intestinal epithelial barrier function and jejunummucosal integrity following epithelial injury. Scientific Report, 6, 36776. (Published).
• *Bilodeau MS, Arguin G, Gendron FP. (2015). C/EBPβ regulates P2X7 expression in response to glucose challenge in intestinal epithelial cells. Biochemistry and Cell Biology, 93(1), 38-46. (Published).
• *Marcil V, *Amre D, Seidman EG, Boudreau F, Gendron FP, Ménard D, Beaulieu JF, Sinnett D, Lambert M, Levy E. (2015). Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youth. PLoS One, 10(2), e0117238. (Published).
• *Vinette V, *Placet M, Arguin G, Gendron FP. (2015). Multidrug resistance-associated protein 2 expression is upregulated by adenosine 5'-triphosphate in colorectal cancer cells and enhances their survival to chemotherapeutic drugs. Plos One, 10(8), e0136080. (Published).
• *Meltzer D, *Ethan O, Arguin G, *Nadel Y, *Danino O, Lecka J, Sévigny J, Gendron FP, Fischer B. (2015). Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists. Bioorg Med Chem., 23(17), 5764-5773. (Published).
• Asselin C, Gendron FP. (2014). Shuttling of information between the mucosal and luminal environment drives intestinal homeostasis. FEBS letters, 588(22), 4148-4157. (Published).
• Turgeon N , *Moore Gagné J ,*Blais M , Gendron FP , Boudreau F , Asselin C. (2014). The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis. American journal of physiology. Gastrointestinal and liver physiology, 306(7), G594-605. (Published).
• *Bourzac JF ,* L'Ériger K , *Larrivée JF , Arguin G , *Bilodeau MS , Stankova J , Gendron FP. (2013). Glucose transporter 2 expression is down regulated following P2X7 activation in enterocytes. Journal of cellular physiology, 228(1), 120-129. (Published).
• *Degagné E , *Degrandmaison J , *Grbic DM , *Vinette V , Arguin G , Gendron FP. (2013). P2Y2 receptor promotes intestinal microtubule stabilization and mucosal re-epithelization in experimental colitis. Journal of cellular physiology, 228(1), 99-109. (Published).
• *Hansen A , Alston L , Tulk SE , Schenck LP , Grassie ME , Alhassan BF , Veermalla AT , Al-Bashir S , Gendron FP , Altier C , MacDonald JA , Beck PL , Hirota SA. (2013). The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction. PloS one, 8(11), e81491. (Published).
• *Marcil V , Sinnett D , Seidman E , Boudreau F , Gendron FP , Beaulieu JF , Menard D , Lambert M , Bitton A , Sanchez R , Amre D , Levy E. (2012). Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease. Genes and immunity, 13(7), 556-565. (Published).
• *Degagné E, Turgeon N, *Moore-Gagné J, Asselin C, Gendron FP. (2012). P2Y(2) receptor expression is regulated by C/EBPβ during inflammation in intestinal epithelial cells. The FEBS journal, 279(16), 2957-2965. (Published).
• *Grbic DM, *Degagne E, *Larrivee JF, *Bilodeau MS, *Vinette V, Arguin G, Stankova J, Gendron FP. (2012). P2Y(6) receptor contributes to neutrophil recruitment to inflamed intestinal mucosa by increasing CXC chemokine ligand 8 expression in an AP-1-dependent manner in epithelial cells. Inflammatory bowel diseases, 18(8), 1456-1469. (Published).
• *Ginsburg-Shmuel T , *Haas M , *Grbic D , Arguin G , Nadel Y , Gendron FP , Reiser G , Fischer B. (2012). UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety. Bioorganic & medicinal chemistry, 20(18), 5483-5495. (Published).
• *Darsigny M, *Babeu JP, Seidman EG, Gendron FP, Levy E, Carrier J, Perreault N, Boudreau F. (2010). Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species. Cancer research, 70(22), 9423-9433. (Published).
• *Marcil V, Seidman E, Sinnett D, Boudreau F, Gendron FP, Beaulieu JF, Ménard D, Precourt LP, Amre D, Levy E. (2010). Modification in oxidative stress, inflammation, and lipoprotein assembly in response to hepatocyte nuclear factor 4alpha knockdown in intestinal epithelial cells. The Journal of biological chemistry, 285(52), 40448-40460. (Published).
• *Taha R, Seidman E, Mailhot G, Boudreau F, Gendron FP, Beaulieu JF, Ménard D, Delvin E, Amre D, Levy E. (2010). Oxidative stress and mitochondrial functions in the intestinal Caco-2/15 cell line. PloS one, 5(7), e11817. (Published).
• Darsigny M, Babeu JP, Dupuis AA, Furth EE, Seidman EG, Lévy E, Verdu EF, Gendron FP, Boudreau F. (2009). Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice. PloS one, 4(10), e7609. (Published).
• Degagné E, Grbic DM, Dupuis AA, Lavoie EG, Langlois C, Jain N, Weisman GA, Sévigny J, Gendron FP. (2009). P2Y2 receptor transcription is increased by NF-kappa B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells. Journal of immunology (Baltimore, Md. : 1950), 183(7), 4521-4529. (Published).
• Langlois C, Gendron FP. (2009). Promoting macrophages transepithelial migration by stimulating the epithelial cell P2Y(2) receptor. European journal of immunology, 39(10), 2895-2905. (Published).
• Grbic DM, Degagné E, Langlois C, Dupuis AA, Gendron FP. (2008). Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. Journal of immunology (Baltimore, Md. : 1950), 180(4), 2659-2668. (Published).
• Boudreau F, Rivard N, Gendron FP, Beaulieu JF. (2007). [CDX2: a transcription factor with multiple tasks for epithelial cells of the digestive tract]. Médecine sciences : M/S, 23(1), 7-8. (Published).
• Gendron FP , Mongrain S , Laprise P , McMahon S , Dubois CM , Blais M , Asselin C , Rivard N. (2006). The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation. American journal of physiology. Gastrointestinal and liver physiology, 290(2), G310-G318. (Published).
• Duval M, Beaudoin AR, Bkaily G, Gendron FP, D' Orléans-Juste P. (2003). Characterization of the NTPDase activities in the mesentery pre- and post-capillary circuits of the guinea pig. Canadian journal of physiology and pharmacology, 81(3), 212-219. (Published).
• Gendron FP, Neary JT, Theiss PM, Sun GY, Gonzalez FA, Weisman GA. (2003). Mechanisms of P2X7 receptor-mediated ERK1/2 phosphorylation in human astrocytoma cells. American journal of physiology. Cell physiology, 284(2), C571-C581. (Published).
• Gendron FP, Chalimoniuk M, Strosznajder J, Shen S, González FA, Weisman GA, Sun GY. (2003). P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells. Journal of neurochemistry, 87(2), 344-352. (Published).
• Gendron FP, Benrezzak O, Krugh BW, Kong Q, Weisman GA, Beaudoin AR. (2002). Purine signaling and potential new therapeutic approach: possible outcomes of NTPDase inhibition. Current drug targets, 3(3), 229-245. (Published).
• Fischer B, Shahar L, Chulkin A, Boyer JL, Harden KT, Gendron FP, Beaudoin AR, Chapal J, Hillaire-Buys D, Petit P. (2000). 2-Thioether-5'-O-(1-thiotriphosphate)-adenosine derivatives: new insulin secretagogues acting through P2Y-receptors. The Israel Medical Association journal : IMAJ, 2 Suppl, 92-98. (Published).
• Gendron FP, Latour JG, Gravel D, Wang Y, Beaudoin AR. (2000). Ca(2+)-channel blockers and nucleoside triphosphate diphosphohydrolase (NTPDase) influence of diltiazem, nifedipine, and verapamil. Biochemical pharmacology, 60(12), 1959-1965. (Published).
• Leclerc MC, Grondin G, Gendron FP, Sévigny J, Beaudoin AR. (2000). Identification, characterization, and immunolocalization of a nucleoside triphosphate diphosphohydrolase in pig liver. Archives of biochemistry and biophysics, 377(2), 372-378. (Published).
• Gendron FP, Halbfinger E, Fischer B, Beaudoin AR. (2000). Inhibitors of NTPDase: key players in the metabolism of extracellular purines. Advances in experimental medicine and biology, 486, 119-123. (Published).
• Gendron FP, Halbfinger E, Fischer B, Duval M, D'Orléans-Juste P, Beaudoin AR. (2000). Novel inhibitors of nucleoside triphosphate diphosphohydrolases: chemical synthesis and biochemical and pharmacological characterizations. Journal of medicinal chemistry, 43(11), 2239-2247. (Published).
• Fischer B , Kabha E , Gendron FP , Beaudoin AR. (2000). Synthesis, mechanism and fluorescence properties of 8-(aryl)-3-beta-D-ribofuranosylimidazo[2,1-i]purine 5'-phosphate derivatives. Nucleosides, nucleotides & nucleic acids, 19(5-6), 1033-1054. (Published).
• Fischer B, Chulkin A, Boyer JL, Harden KT, Gendron FP, Beaudoin AR, Chapal J, Hillaire-Buys D, Petit P. (1999). 2-thioether 5'-O-(1-thiotriphosphate)adenosine derivatives as new insulin secretagogues acting through P2Y-Receptors. Journal of medicinal chemistry, 42(18), 3636-3646. (Published).
• Benrezzak O, Grondin G, Sévigny J, Gendron FP, Rousseau E, D'Orléans-Juste P, Beaudoin AR. (1999). Identification and immunolocalization of two isoforms of ATP-diphosphohydrolase (ATPDase) in the pig immune system. Archives of biochemistry and biophysics, 370(2), 314-322. (Published).
• Beaudoin AR, Grondin G, Gendron FP. (1999). Immunolocalization of ATP diphosphohydrolase in pig and mouse brains, and sensory organs of the mouse. Progress in brain research, 120, 387-395. (Published).
• Sévigny J, Grondin G, Gendron FP, Roy J, Beaudoin AR. (1998). Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system. The American journal of physiology, 275(3 Pt 1), G473-G482. (Published).

Chapitres de livre

• Gendron FP, *Placet M, Arguin G. (2017). P2Y? receptor functions in cancer: a perspective in the context of colorectal cancer. Springer Advances in Experimental Medicine and Biology (1051, 91-106). United States : Springer, Boston, MA. (Published).

Articles de conférence

• Molle CM*, Gendron FP. (2019). A new role for the P2X7 receptor in the development of the intestinal epithelium. Canadian Digestive Diseases Week-Research Topics in GI disease. (Accepted).
• Molle CM*, Arguin G, Jean S, Gendron FP. (2019). A new role for the P2X7 receptor in the development of the intestinal epithelium. Canadian Digestive Diseases Week. (Accepted).
• Girard M*, Dagenais Bellefeuille S*, Arguin G, Longpré JM, Sarret P, Gendron FP. (2019). Characterization of receptor P2Y6 signaling in cell migration. Canadian Digestive Diseases Week. (Accepted).
• Placet M*, McManus S*, Arguin G, Savard M, Gendron FP, Gobeil F Jr. (2019). Could B1R be an actor in tumorigenicity of U87MG cells via EMT-like mechanism. Chronic Inflammation, Immunity and Cancer. (Accepted).
• Molle CM*, Arguin G, Jemfer C*, Dagenais Bellefeuille S*, Placet M*, Gendron FP. (2019). Identification of the molecular determinants regulating P2X7 receptor expression in intestinal epithelial cells and how it could impact their sensitivity to apoptosis. Chronic Inflammation, Immunity and Cancer. (Accepted).
• Dagenais Bellefeuille S*, Arguin G, Gendron FP. (2019). On the trail of alternative signaling pathways and ligands for LGR5. Chronic Inflammation, Immunity and Cancer. (Accepted).
• Girard M*, Dagenais Bellefeuille S*, Placet M*, Arguin G, Longpré JM, Sarret P, Gendron FP. (2019). The P2Y6 receptor stimulates cell migration through a Gαq-dependent pathway. GPCR Retreat. (Accepted).
• Girard M*, Arguin G, Longpré JM, Sarren P, Gendron FP. (2018). Caractérisation du rôle du récepteur P2Y6 dans la migration cellulaire. Journée Phare. (Accepted).
• Girard M*, Dagenais Bellefeuille S*, Arguin G, Longpré JM, Sarret P, Gendron FP. (2018). Caractérisation du rôle du récepteur P2Y6 dans la migration cellulaire. Club de Recherches Cliniques du Québec 60th edition. (Accepted).
• Placet M*, Grbic DM*, Bourzac JF*, Molle CM*, Arguin G, Gendron FP. (2018). The P2Y6 Receptor: A Colorectal Tumorigenesis’ Actor?. Canadian Digestive Diseases Week. (Accepted).
• Girard M*, Dagenais Bellefeuille S*, Arguin G, Longpré JM, Sarret P, Gendron FP. (2017). Caractérisation du rôle du récepteur P2Y6dans la migration cellulaire. Journée Phare. (Accepted).
• Nepveu-Traversy ME*, Morissette S, Boudreault PL, Besserer-Offroy E, Kirby K, Breton B, Longpré JM, Marsault E, Gendron FP, Gaudreau S, Sarret, P. (2017). Characterization of chicken antibodies targeting the 3D structure of the second extracellular loop of the neurotensin receptor type 1. PEGS Summit. (Published).
• Nepveu-Traversy ME*, Morissette S, Boudreaul, PL, Besserer-Offroy E, Kirby K, Breton B, Longpré JM, Marsault E, Gendron FP, Gaudreau S, Sarret P. (2017). Chicken antibodies engineered to target the 3D structure of extracellular loops of GPCRs. 2017 GPCR retreat. (Published).
• Placet M*, Molle CM*, Grbic GM*, Arguin G, Geha S, Gendron FP. (2017). The G protein-coupled P2Y6 pyrimidoceptor increases tumorigenesis potential of epithelial cell in colorectal cancer associated colitis. AACR annual meeting 2017. (Accepted).
• Placet M*, Molle CM*, Grbic DM*, Arguin G, Samen G, Gendron FP. (2017). The G protein-coupled P2Y6 pyrimidoceptor increases tumorigenesis potential of epithelial cell in colorectal cancer associated to colitis. AACR Annual Meeting 2017. (Accepted).
• Molle CM*, Placet M*, Arguin G, Gendron FP. (2017). The role of p53 on P2Y6R expression in colorectal cancer. Canadian Digestive Diseases Week 2017. (Accepted).
• GaudreauS, Boudreault P-L, Gendron FP, Traboulsi H, Marsault E, Sarret P, Leduc F, Arcand M. (2016). 3D-specific IgYantibodies targeting GPCR extracellular loops. 12the Annuel PEGS Boston. (Accepted).
• GaudreauS, Nepveu-Traversy ME*, Morissette S, Boudreault PL, Trabloussi H, Held P, Banks P, Arcand M, Breton B, Marsault E, Gendron FP, Sarret P. (2016). 3D-specific chicken antibodies targeting GPCR extracellular loops. Protein Discovery Summit 2016. (In Press).
• Gaudreau S, Nepveu-Traversy ME*, Morissette S, Boudreault PL, Trabloussi H, Held P, Banks P, Arcand M, Breton B, Marsault E, Gendron FP, Sarret P. (2016). 3D-specific chicken antibodies targeting GPCR extracellular loops. Discovery on Target 2016 15th edition. (Published).
• Nepveu-Traversy ME*, Morissette S, Boudreault PL, Besserer-Offroy E, Kirby K, Breton B, Longpré JM, Marsault E, Gendron FP, Gaudreau S, Sarret, P. (2016). Caractérisation d’anticorps IgY reconnaissant la structure 3D de la deuxième boucle extracellulaire du récepteur NTS1 de la neurotensine. Journée Phare 2016. (Published).
• Molle CM*, Placet M*, Arguin G, Gendron FP. (2016). Regulation of P2Y6 receptor expression by p53. Canadian Digestive Disease Week 2016. (Accepted).
• Placet M*, Molle C, Arguin G, Geha S, Gendron FP. (2016). The G protein-coupled P2Y6 pyrimidoceptor protects colorectal cancerous epithelial cells from apoptosis: Is this receptor a novel target against colorectal cancer?. Annual Meeting of the American Association for Cancer Research. (Accepted).
• *Placet M, *Molle CM, Arguin G, Geha S, Gendron FP. (2016). The G protein-coupled P2Y6 pyrimidoceptor protects colorectal cancerous epithelial cells from apoptosis: Is this receptor a novel target against colorectal cancer?. AACR annual meeting 2016. (Accepted).
• Molle CM*, Placet M*, Grbic DM*, Arguin G, Gendron FP. (2015). Caractérisation des mécanismes moléculaires régulant l’expression du récepteur P2Y6 dans le cancer colorectal. Journée scientifique de la Faculté de Médecine et des Sciences de la Santé. (Published).
• Placet M*, Grbic DM*, Bourzac JF*, Molle C*, Arguin G, Gendron FP. (2015). THE P2Y6 RECEPTOR: A COLORECTAL TUMORIGENESIS' ACTOR?. Canadian Digestive Diseases Week 2015. (Published).
• Placet M*, Grbic DM*, Bourzac JF*, Molle CM*, Arguin G, Gendron FP. (2015). The P2Y6 receptor : A colorectal Tumorigenesis’ Actor?. IRSC Institute of Nutrition, Metabolism and Diabetes (INMD). (Published).
• *Gonneaud A, Turgeon N, Boudreau F, Gendron FP, Asselin C. (2014). Variations of intestinal epithelial HDAC1 and HDAC2 protein levels lead to changes in gut homeostasis. Canadian Digestive Disease Week 2014. (Accepted).
• Grbic, D.M., Larrivée, J.F., Degagné , E., Vinette, V., Bilodeau, M., Bourzac, J.F., Arguin, G., Stankova, J., and Gendron, F.P. (2013). EXTRACELULLAR UDP IS SUFFICENT TO TRIGGER AN INFLAMMATORY OUTBURST IN CHRONIC COLITIS MOUSE MODEL. Canadian Digestive Diseases Week 2013. (Accepted).
• *Grbic DM, *Larrivée JF, *Degagné E, *Vinette V, *Bilodeau MS, *Bourzac JF, Arguin G, Stankova J, Gendron FP. (2013). Extracellular UDP is sufficient to trigger an inflammatory outburst in chronic colitis mouse model. Canadian Digestive Diseases Week 2013. (Accepted).
• *Bourzac JF, Arguin G, Gendron FP. (2013). Implications du récepteur P2X7 dans le métabolisme de la digestion dans l'intestin de souris. 55e Réunion annuelle du Club de recherche clinique du Québec. (Accepted).
• Turgeon N, *Moore-Gagné J, Blais M, Boudreau F, Gendron FP, Asselin C. (2013). Intestinal epithelial HDAC1 and HDAC2 deficient mice are more sensitive to DSS-induced colitis. 10th Symposium on the Physiology and Diseases of the Digestive Tract. (Accepted).
• *Lepage D, *Tremblay S, Gendron FP, Asselin C, Menendez A, Boudreau F. (2013). Role of GATA4 in regulating intestinal epithelial barrier and protecting against bacterial infection. ASCB annual meeting. (Accepted).
• *Bourzac JF, Arguin G, Gendron FP. (2013). Role of P2X7 receptor in the establishment of jejunum morphology and glucose absorption by the intestine. 10th Symposium on the Physiology and Diseases of the Digestive Tract. (Accepted).
• *Grbic DM, Arguin G, Bernatchez G, Carrier J, Gendron FP. (2013). The deregulation of P2Y6 receptor expression confers a growth advantage to colorectal cancer cells. ASCB annual meeting. (Accepted).
• *Grbic DM, *Larrivée JF, Bernatchez G, Carrier J, Stankova J, Gendron FP. (2013). The deregulation of P2Y6 receptor expression confers a growth advantage to colorectal cancer cells. Canadian Digestive Diseases Week 2013. (Accepted).
• *Degagné É, Gendron FP. (2012). Increased expression of P2Y2 receptor during inflammatory bowel diseases is regulated by transcription factor C/EBP?. Canadian Digestive Disease Week 2012. (Published).
• *Vinette V, *Grbic DM, Gendron FP. (2012). Intestinal inflammation upregulates the expression of transporter MRP2 - potential involvement in IBD and colorectal cancer. Canadian Digestive Disease Week 2012. (Published).
• *Grbic DM, *Larrivée JF, Arguin G, Bernatchez G, Carrier J, Stankova J, Gendron FP. (2012). P2Y6 receptor activity is increased in colorectal epithelial cancer cells with p53 mutation and provides a growth advantage by protecting cells from TNF-? induced apoptosis. Keystone Symposia on molecular and cellular biology: The role of inflammation during carcinogenesis. (Published).
• *St-Jean S, *Grbic DM, Gendron FP, Boudreau F. (2012). The nuclear corepressor NCOR1 is a novel regulator of the inflammatory response in colorectal cancer cells. Keystone Symposia on molecular and cellular biology: The role of inflammation during carcinogenesis. (Published).
• *St-Jean S, Jones C, *Grbic DM, Gendron FP, Boudreau F. (2012). The nuclear corepressor Ncor1 is a novel regulator of the inflammatory response in intestinal epithelial cells. Canadian Digestive Disease Week 2012. (Published).
• *Bilodeau MS, *Bourzac JF, Gendron FP. (2012). The regulation of P2X7 receptor expression in response to glucose level variation. Canadian Digestive Disease Week 2012. (Published).
• Babakissa C, Gendron FP, Arguin G, Langlois C, Turcotte S, Rola-Plesczynski M. (2011). Correlation of Crohn's disease severity with expression levels of leukotriene B4 receptor. 44th Annual Meeting of ESPGHAN. (Published).
• Babakissa C, Gendron FP, Arguin G, Langlois C, Turcotte S, Rola-Plesczynski M. (2011). Correlation of Crohn's disease severity with expression levels of leukotriene B4 receptor. 1st international symposium on the physiology and diseases of the digestive tract. 1st international symposium on the physiology and diseases of the digestive tract. (Published).
• *Grbic DM, *Larrivée JF, *Vinette V, *Rémy J, Arguin G, Stankova J, Fischer B, Gendron FP. (2011). Modulating intestinal immune functions using P2Y6 receptor agonists and antagonists, new insights. 1st international symposium on the physiology and diseases of the digestive tract. (Published).
• *Grbic DM, *Larrivée JF, *Vinette V, *Rémy J, Arguin G, Stankova J, Fischer B, Gendron FP. (2011). Modulating intestinal immune functions using P2Y6 receptor agonists and antagonists. Banff Inflammation Workshop 2011. (Published).
• *Yara S, *Taha R, *Marcil V, Beaulieu JF, Boudreau F, Gendron FP, Lavoie JC, Seidman E, Levy E. (2011). Nrf2 silencing induces oxidative stress, inflammation and mitochondrial dysfunctions in the intestine. SFRBM's 18th Annual Meeting. (Published).
• *Degagné É, Arguin G, *Grbic DM, Gendron FP. (2011). P2Y2 receptor interaction with integrin ?v promotes restitution of a wounded monolayer of intestinal epithelial cells. 1st international symposium on the physiology and diseases of the digestive tract. (Published).
• *Bourzac JF, Gendron FP. (2011). The ATP-dependant P2X7 is a novel actor in the regulation of glucose absorption by enterocytes. Canadian Digestive Disease Week 2011. (Published).
• *Bourzac JF, Gendron FP. (2011). The ATP-dependant P2X7 is a novel actor in the regulation of glucose absorption by enterocytes. Research Topics in GI Disease X. (Published).
• *Bourzac JF, *L'Ériger K, *Larrivée, JF, Arguin G, *Bilodeau MS, Langlois C, Stankova J, Gendron FP. (2011). The P2X7 ionotropic receptor regulates the expression of the facilitated transporter of glucose Glut2 in intestinal epithelial cells. 1st international symposium on the physiology and diseases of the digestive tract. (Published).
• *Bilodeau MS, *Bourzac JF, *L'Ériger K, *Marois I, Gendron FP. (2011). The regulation of P2X7 receptor expression in response to glucose level variation. 1st international symposium on the physiology and diseases of the digestive tract. (Published).
• *Darsigny M, *Babeu JP, Levy E, Seidman EG, Gendron FP, Rivard N, Carrier J, Perreault N, Boudreau F. (2010). Hnf4? Protects Against Reactive Oxygen Species and Promotes Gut Neoplasia. Digestive Disease Week 2010. (Published).
• *St-Jean S, *Grbic GM, Gendron FP, Boudreau F. (2010). Implication du corépresseur NCOR1 dans le contrôle de l'expression de CXCL8 durant la réponse inflammatoire épithéliale intestinale. 52e réunion annuelle du CRCQ. (Published).
• *Bourzac JF, *L’Ériger K, *Larrivée JF, Langlois C, Gendron FP. (2010). L'ATP extracellulaire régule l'expression membranaire du transporteur Glut2 des cellules épithéliales intestinales et implique l'activation de la protéine kinase atypique PKD par le récepteur P2X7. 52e réunion annuelle du CRCQ. (Published).
• *Bourzac JF, *L’Eriger K, *Larrivee JF, Langlois C, Gendron FP. (2010). L’ATP extracellulaire régule l’expression membranaire du transporteur GLUT2 des cellules épitheliales intestinales et implique l’activation de la proteine kinase atypique PKD par le récepteur P2X7. Signalisation Quebec 2010. (Published).
• *Degagne E, *Grbic DM, Langlois C, Gendron FP. (2010). P2Y2 Receptor Promotes Intestinal Epithelial Cell Migration Implying a Role in Epithelial Restitution. Digestive Disease Week 2010. (Published).
• *Grbic DM, Langlois C, *Degagne E, Gendron FP. (2010). The P2Y6 Receptor Induces the Expression of Cxcl8 Through an ERK-Dependent Activation of C-FOS/C-Jun AP-1 Transcriptional Complex. Signalisation Quebec 2010. (Published).
• *Grbic DM, *Degagne E, Langlois C, Gendron FP. (2010). The P2Y6 Receptor Induces the Expression of Cxcl8 Through an ERK-Dependent Activation of C-FOS/C-Jun AP-1 Transcriptional Complex. Digestive Disease Week 2010. (Published).

Propriétés intellectuelles

Patents

• (2003). Analogues de nucléotides substitués en position C8 et leur utilisation comme inhibiteurs des NTPDases. 6,617,439. Canada. (Granted/Issued).

Autres contributions

Cours enseignés

• Biologie cellulaire-Compartiments cellulaires. BCL726. Niveau : Graduate.
• Biologie cellulaire-Mécanisme d'endocytose et d'exocytose. BCL726.
• Biologie cellulaire-Signalisation. BCL726.
• Cytophysiologie-Compartiments cellulaires et distribution des protéines. BCL106.
• Cytophysiologie intestinale-Digestion et absorption des sucres. BCL721.
• Sciences biologiques. PHT125.
• Signalisation intracellulaire-Signalisation par les récepteurs couplés aux protéines G. BCL740.

Gestion d'évènements

• President. (2015). 11th Symposium on the Physiology and Diseases of the Digestive Tract. (Conference).
• Co-organizer and chair. (2015). CDDW 2015 - Trainee session: Explore Your Options (academia & alternative careers). (Workshop).
• Co-organizer. (2013). 10th Symposium on the Physiology and Diseases of the Digestive Tract. (Conference).
• Co-organizer and chair. (2011). 1st International Symposium on the Physiology and Diseases of the Digestive Tract. (Conference).

Présentations

• (2015). I am an university professor: A world of opportunity. Canadian Digestive Diseases Week 2015. Banff, Canada.
• (2015). Les récepteurs nucléotidiques P2X7 et P2Y6 comme de nouvelles cibles dans le traitement de l’inflammation intestinale, du cancer colorectal et les désordres glycémiques. Institute of Pharmacology - selected conference event. Sherbrooke, Canada.
• (2012). La signalisation par le récepteur P2Y6 dans les cellules épithéliales intestinales: inflammation ou cancer?. Signalisation Québec 2012. Bécancourt, Canada.
• (2011). Extracellular nucleotides in the intestine: the good, the bad and the not so bad finally. 1st international symposium on the physiology and diseases of the digestive tract. Orford, Canada.
• (2011). IBD Research, A Glimpse into the Future of IBD Suffering Patients. CCFC Education Symposium 2011: Living well with IBD - IBD Research. Saint John, Canada.
• (2011). Le récepteur à l’ATP P2X7 est un nouvel acteur dans la régulation de l’absorption du glucose par les entérocytes. 79e congrès de l’ACFAS. Sherbrooke, Canada.
• (2011). Les maladies inflammatoires intestinales, un mal méconnu: une ouverture vers les nouvelles avenues de recherche. 32e Congrès annuel de la Société québécoise de biologie Clinique. St-Hyacinthe, Canada.
• (2011). Modulating P2Y nucleotide receptors signaling for the treatment of inflammatory bowel diseases. Bar-Ilan University. Ramat Gan, Israel.
• (2011). Regulating P2Y2 and P2Y6 nucleotide receptors activity as a mean to treat IBD: Is this the new Eldorado for the development of novel drugs or will it be our Waterloo?. Banff inflammation workshop 2011. Banff, Canada.
• (2010). Les récepteurs nucléotidiques P2Y2 et P2Y6 participent au maintien de l’homéostasie de la muqueuse intestinale. CRRI-Université Laval. Quebec, Canada.
• (2010). Les récepteurs nucléotidiques P2Y et P2X participent au maintien de l’homéostasie de la muqueuse intestinale. Centre de Recherche du CHU Sainte-Justine. Montreal, Canada.
• (2010). Purinergic Signaling to the Gut Immune System. Canadian Digestive Disease Week 2010. Toronto, Canada.
• (2009). Moduler la signalisation des récepteurs nucléotidiques P2Y comme outils thérapeutiques dans le traitement des maladies inflammatoires de l’intestin. Inserm-unité 563. Toulouse, France.
• (2009). P2Y Nucleotide Receptors: the 21st Century’s "El Dorado" of Anti-inflammatory Bio-molecules. 3rd World congress of gene, Dec. 1-7. Foshan, China.
• Degagné, É., Grbic, D., Lavoie, É., Dupuis, A.-A., Sévigny, J. (2008). Intestinal inflammation up-regulates the expression of the G protein-coupled receptor P2Y2 at the transcriptional level. Purines 2008, June 29 – July 2nd. Copenhagen, Denmark.
• (2008). Les nucléotides extracellulaires sont des interlocuteurs importants du maintien de l’homéostasie de l’épithélium intestinal. Les conférences de la recherche, Centre de recherche Étienne-Le Bel. Sherbrooke, Canada.
• Francois Boudreau Julie Carrier. (2008). «Maladie de Crohn et colite ulcéreuse: Comprendre les maladies inflammatoires de l’intestin pour un avenir en meilleure santé». CCFC Education Symposium 2008. Sherbrooke, Canada.
• K. L'Ériger. (2007). A new role for the deadly P2X7 receptor: the differentiation of intestinal epithelial cells. Gastrointestinal Diseases Research Unit during the International Symposium “At the cutting edge of Neuromuscular and epithelial GI physiology. Kingston, Canada.
• (2007). La signalisation nucléotidique et son implication dans les maladies inflammatoires intestinales. Matinée des chercheurs boursiers - 49ième réunion annuelle du CRCQ. Mont-Tremblant, Canada.
• (2007). P2 nucleotide receptors signalling in intestinal epithelial cells: New implications for your friendly neighbour. Queens University. Kingston, Canada.
• (2005). Les rôles et fonctions des récepteurs nucléotidiques P2 dans la réponse inflammatoire des cellules épithéliales intestinales. 4ième Symposium sur les physiopathologies du tube digestif. Orford, Canada.
• A.R. Beaudoin. (2000). NTPDase from biology to chemistry. Lecture. Ramat-Gan, Israel.