Présentation

Sujets de recherche

Arthrite / arthrose, Maladies du tissu osseux, Ostéoporose.

Disciplines de recherche

Pharmacologie, Rhumatologie.

Mots-clés

Binding Assay, Cyclooxygénase, Os, Ostéoclastes, Ostéoporose, Prostaglandine, Récepteurs prostaglandine, Second Messengers.

Intérêts de recherche

Pathophysiologie osseuse, plus spécifiquement le rôle des prostaglandines et ses récepteurs dans le contrôle du métabolisme des ostéoblastes et des ostéoclastes.

Recherche clinique

Oui

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Espagnol (castillan), Français, Portuguais

Prix et distinctions

• Prix Étienne-LeBel. (Prix / Récompense).

Publications

Articles de revue

• Leblanc-Trudeau, C. Dobkin, P. L. Carrier, N. Cossette, P. de Brum-Fernandes, A. J. Liang, P. Masetto, A. Boire, G. (2015). Depressive symptoms predict future simple disease activity index scores and simple disease activity index remission in a prospective cohort of patients with early inflammatory polyarthritis. Rheumatology (Oxford), 54(12), 2205-14.
• Yue, L. Haroun, S., Parent, J.L.Brum-Fernandes, A.J. (2014). Prostaglandin D2 induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways. Bone, 60, 112-121. (Article publié).
• Allard-Chamard, H., Dufort, P., Haroun, S., de Brum-Fernandes, A.F. (2014). in vitroCytosolic Phospholipase A2 andeicosanoids modulate life, death and function of human osteoclasts . PLEFA, 90(4), 117-123. (Article publié).
• Allard-Chamard, H., Haroun, S. de Brum-Fernandes, A.J. (2014). in vitroSecreted Phospholipase A2 type II is present inPaget's disease of bone and modulates osteoclastogenesis, apoptosis and boneresorption of human osteoclasts independently of its catalytic activity . PLEFA, 90, 39-45. (Article publié).
• Néron S , Boire G , Dussault N , Racine C , de Brum-Fernandes AJ , Côté S , Jacques A. (2014). CD40-activated B cells from patients with systemic lupus erythematosus can be modulated by therapeutic immunoglobulins in vitro. Archivum immunologiae et therapiae experimentalis, 57(6),
• Dobkin PL , Liu A , Abrahamowicz M , Carrier N , de Brum-Fernandes AJ , Cossette P , Boire G. (2013). Predictors of pain for patients with early inflammatory polyarthritis. Arthritis care & research, 65(6),
• Durand M , Komarova SV , Bhargava A , Trebec-Reynolds DP , Li K , Fiorino C , Maria O , Nabavi N , Manolson MF , Harrison RE , Dixon SJ , Sims SM , Mizianty MJ , Kurgan L , Haroun S , Boire G , de Fatima Lucena-Fernandes M , de Brum-Fernandes AJ. (2013). Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: the In Vitro Osteoclast Differentiation in Arthritis study. Arthritis and rheumatism, 65(1),
• Yue L , Durand M , Lebeau Jacob MC , Hogan P , McManus S , Roux S , de Brum-Fernandes AJ. (2012). Prostaglandin D(2) induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. Bone, 51(3), 338-346.
• Durand M , Boire G , Komarova SV , Dixon SJ , Sims SM , Harrison RE , Nabavi N , Maria O , Manolson MF , Mizianty M , Kurgan L , de Brum-Fernandes AJ. (2011). The increased in vitro osteoclastogenesis in patients with rheumatoid arthritis is due to increased percentage of precursors and decreased apoptosis - the In Vitro Osteoclast Differentiation in Arthritis (IODA) study. Bone, 48(3),
• Mathurin K , Gallant MA , Germain P , Allard-Chamard H , Brisson J , Iorio-Morin C , de Brum Fernandes A , Caron MG , Laporte SA , Parent JL. (2011). An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production. The Journal of biological chemistry, 286(4),
• Guzian MC , Carrier N , Cossette P , de Brum-Fernandes AJ , Liang P , Ménard HA , Boire G. (2010). Outcomes in recent-onset inflammatory polyarthritis differ according to initial titers, persistence over time, and specificity of the autoantibodies. Arthritis care & research, 62(11),
• Roy SJ , Parent A , Gallant MA , de Brum-Fernandes AJ , Stanková J , Parent JL. (2010). Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. European journal of pharmacology, 630(1-3),
• Gallant MA , Chamoux E , Bisson M , Wolsen C , Parent JL , Roux S , de Brum-Fernandes AJ. (2010). Increased concentrations of prostaglandin D2 during post-fracture bone remodeling. The Journal of rheumatology, 37(3),

Propriétés intellectuelles

Brevets

• Diagnostic Method and Prognostic Tool for Osteoarthritis. 61/106,001. (Retiré).
• Diagnostic Method and Prognostic Tool for Rheumatoid Arthritis. 12/250,896. (Retiré).

Autres contributions

Cours enseignés

• PHR 504. Université de Sherbrooke. Canada.
• Unité de l'appareil locomoteur. Université de Sherbrooke. Canada.