Bisaillon, Martin

Vice-doyen & Secrétaire de faculté, Faculté de médecine et des sciences de la santé

Coordonnées

Courriel


819-821-8000, poste 75904

Diplômes

(2001) Post-doctorate (Postdoctorate Molecular Biology). Memorial Sloan-Kettering Cancer Center.

(1999) Doctorate (Microbiology and immunology). Université de Montréal.

Expérience académique

(2017) Vice-Dean of Students Affairs and Secretary of the Faculty (Vice-doyen à la vie étudiante et Secrétaire facultaire). Université de Sherbrooke.

Présentation

Sujets de recherche

Virus.

Disciplines de recherche

Biochemistry.

Mots-clés

Protein biochemistry, Protein expression, RNA viruses.

Intérêts de recherche

We are actively investigating the kinetic and thermodynamic parameters that are associated with the binding of various ligands to viral enzymes involved in the synthesis and maturation of mRNAs.

Centres de recherche

Centre de recherche du CHUS, None.

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2016) Chercheur-boursier Sénior. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • (2012) Chercheur-boursier Junior II. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • (2008) New Investigator Award. Canadian Institutes of Health Research. (Prize / Award).
  • (2006) Chercheur-boursier Junior 1. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • Excellence in Teaching Award. Université de Sherbrooke. (Prize / Award).
  • Marcel-Bastin Award for outstanding teaching. Université de Sherbrooke. (Prize / Award).
  • Marcel-Bastin Award for outstanding teaching. Université de Sherbrooke. (Prize / Award).
  • Marcel-Bastin Award for outstanding teaching. Université de Sherbrooke. (Prize / Award).

Financement

Grant. (Awarded). Principal Applicant. Molecular basis of protein-ligand interactions.. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grants Program. 145000 $ (2016-2021).

Grant. (Awarded). Co-applicant. Mechanisms of antiviral drug resistance for Herpesviruses.. (2015-2020).

Grant. (Awarded). Co-applicant. Nouveaux biomarqueurs pour la détection précoce du cancer oropharyngé.. Département de chirurgie - FMSS. Research funds. 32000 $ (2017-2018).

Grant. (Awarded). Co-investigator. Développement et validation d’essais moléculaires d’expression génique permettant une meilleure stratification du risque associé aux oligodendrogliomes IDH-mutés 1p/19q-codélétés et aux gliomes IDH-wt.. Merck Sharpe & Dohme. Research funds. 67000 $ (2017-2018).

Grant. (Awarded). Co-investigator. Nouveaux biomarqueurs urinaires pour la détection de récidive tumorale : les événements d’épissage alternatif comme nouvel outil diagnostic chez les patients atteints du cancer de la vessie. Merck Sharpe & Dohme. Research funds. 67000 $ (2017-2018).

Grant. (Awarded). Co-applicant. Development of serodiagnostic biomarkers for Candidemia.. Canadian Institutes of Health Research (CIHR). Project Grant. 100000 $ (2016-2017).

Grant. (Awarded). Co-applicant. Études structurales et fonctionnelles d'une nouvelle classe de protéines transportant l'hème.. (2015-2017).

Fellowship. (Awarded). Principal Investigator. Caractérisation des déterminants moléculaires impliqués dans la maturation des ARN viraux.. (2012-2016).

Grant. (Awarded). Principal Applicant. Modifications des événements d'épissage alternatif dans les cancers induits par les virus: un nouveau paradigme pour la recherche translationnelle et la médecine personnalisée.. (2015-2016).

Grant. (Awarded). Principal Applicant. Molecular basis of protein-ligand interactions.. (2015-2016).

Grant. Molecular basis of protein-ligand interactions.. (2015-2016).

Grant. (Awarded). Co-investigator. Nouveau biomarqueur pour contrer les fungémies. Centre de recherche clinique du CHUS. Programme PAFI. 25000 $ (2015-2016).

Grant. (Awarded). Principal Applicant. Modifications de l'épissage alternatif de gènes impliqués dans le cancer lors d'infections virales.. (2014-2015).

Grant. (Awarded). Co-investigator. Centre de biologie de l'ARN. (2012-2015).

Grant. (Awarded). Co-applicant. Innovative and flexible tools for protein purification and molecule binding studies.. (2014-2015).

Grant. (Awarded). Principal Investigator. Molecular basis of protein-ligand interactions. (2010-2015).

Grant. (Awarded). Principal Investigator. Biological implications of RNA decapping during vaccinia virus infection.. (2012-2015).

Fellowship. (Completed). Principal Investigator. Caractérisation des déterminants moléculaires impliqués dans la synthèse et la maturation des ARN viraux.. (2008-2012).

Grant. (Completed). Principal Investigator. Biological implications of RNA decapping during vaccinia virus infection.. (2011-2012).

Grant. (Completed). Co-investigator. Centre de biologie de l'ARN. (2009-2012).

Grant. (Completed). Principal Investigator. Characterization of the molecular determinants involved in the synthesis and maturation of viral RNAs.. (2006-2011).

Grant. (Completed). Co-investigator. Platform for the study of RNA structure, function, and evolution. (2005-2010).

Grant. (Completed). Principal Investigator. Development of a SOFA-ribozyme-based strategy to control the propagation of the influenza virus.. (2009-2010).

Grant. (Completed). Principal Investigator. Structural and mechanistic studies of proteins involved in the replication of the West Nile virus.. (2004-2009).

Grant. (Completed). Co-investigator. Acquisition of an imaging system for quantification of DNA, RNA, and proteins.. (2008-2009).

Grant. (Completed). Principal Investigator. Development of a SOFA-ribozyme-based strategy to control the propagation of the influenza virus. (2008-2009).

Fellowship. (Completed). Principal Investigator. Identification and characterization of molecular determinants involved in the RNA capping chemistry of viral proteins.. (2003-2008).

Grant. (Completed). Co-investigator. Acquisition of a scintillation counter. (2007-2008).

Grant. (Completed). Co-investigator. A metal-free water purification system. (2006-2007).

Fellowship. Élucidation du mécanisme moléculaire des protéines impliquées dans la synthèse de la structure coiffe des ARN messagers.. (2002-2006).

Grant. (Completed). Principal Investigator. A centrifuge for the analysis and characterization of proteins.. (2005-2006).

(Completed). Principal Investigator. Identification and characterization of the molecular determinants involved in the RNA capping chemistry of viral proteins.. (2003-2006).

(Completed). Principal Investigator. Élucidation du mécanisme moléculaire des protéines impliquées dans la synthèse de la structure coiffe des ARN messagers.. (2002-2005).

(Completed). Principal Investigator. Combined experimental approaches for the study of protein-ligand interactions.. (2004).

(Completed). Principal Investigator. Élucidation du mécanisme moléculaire des protéines impliquées dans la synthèse de la structure coiffe des ARN messagers.. (2002-2003).

Grant. (Completed). Principal Investigator. Caractérisation des déterminants moléculaires impliqués dans la synthèse et la maturation des ARN viraux.. (2002-2003).

Fellowship. (1999-2002).

Fellowship. (1999-2001).

Fellowship. (1998-1999).

Fellowship. (1997).

Fellowship. (1997).

Fellowship. (1992-1993).

Fellowship. (1991-1992).

Publications

Articles de revue

  • Brodeur CM, Thibault P, Durand M, Perreault JP, Bisaillon M. (2019). Dissecting the expression landscape of cytochromes P450 in hepatocellular carcinoma: towards novel molecular biomarkers. Genes Cancer, 10, 97-108.
  • Jodoin R, Carrier J, Rivard N, Bisaillon M, Perreault JP. (2019). G-quadruplex located in the 5’UTR of the BAG-1 mRNA affects both its cap-dependent and cap-independent translation through global secondary structure maintenance. Nucleic Acids Res, 47, 10247-10266.
  • Lanoie D, Boudreault S, Bisaillon M, Lemay G. (2019). How Many Mammalian Reovirus Proteins are involved in the Control of the Interferon Response?. Pathogens, 8, E83.
  • Boudreault S, Armero VES, Scott MS, Perreault JP, Bisaillon M. (2019). The Epstein-Barr virus EBNA1 protein modulates the alternative splicing of cellular genes. Virol J, 16, 29.
  • Boudreault S, Roy P, Lemay G, Bisaillon M. (2019). Viral modulation of cellular RNA alternative splicing: A new key player in virus-host interactions?. Wiley Interdiscip Rev RNA, 10, e1543.
  • Picard-Jean F, Brand C, Tremblay-Létourneau M, Allaire A, Beaudoin MC, Boudreault S, Duval C, Rainville-Sirois J, Robert F, Pelletier J, Geiss BJ, Bisaillon M. (2018). 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO. PLoS One, 13(3), e0193804. (Published).
  • Rouleau SG, Garant JM, Bolduc F, Bisaillon M, Perreault JP. (2018). G-Quadruplexes influence pri-microRNA processing. RNA Biol., 15(2), 198-206. (Published).
  • Rouleau SG, Glouzon JS, Brumwell A, Bisaillon M, Perreault JP. (2017). 3' UTR G-Quadruplexes regulate miRNA binding. RNA, May 4, 1172-1179. (In Press).
  • Brand C, Bisaillon M, Geiss BJ. (2017). Organization of the Flavivirus RNA replicase complex. Wiley Interdiscip Rev RNA., 8(6), e1437. (Published).
  • Armero VES, Tremblay MP, Allaire A, Boudreault S, Martenon-Brodeur C, Duval C, Durand M, Lapointe E, Thibault P, Tremblay-Létourneau M, Perreault JP, Scott MS, Bisaillon M. (2017). Transcriptome-wide analysis of alternative RNA splicing events in Epstein-Barr virus-associated gastric carcinomas. PLoS One, 12(5), e0176880. (Published).
  • Boudreault S, Martenon-Brodeur C, Caron M, Garant JM, Tremblay MP, Armero VE, Durand M, Lapointe E, Thibault P, Tremblay-Létourneau M, Perreault JP, Scott MS, Lemay G, Bisaillon M. (2016). Global Profiling of the Cellular Alternative RNA Splicing Landscape during Virus-Host Interactions. PLoS One, 11, e0161914. (Published).
  • Tremblay MP, Armero VE, Allaire A, Boudreault S, Martenon-Brodeur C, Durand M, Lapointe E, Thibault P, Tremblay-Létourneau M, Perreault JP, Scott MS, Bisaillon M. (2016). Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma. BMC Genomics, 17, 683. (Published).
  • Allaire A, Picard-Jean F, Bisaillon M. (2015). Immunofluorescence to monitor the cellular uptake of human lactoferrin and its associated antiviral activity against the Hepatitis C Virus. J Vis Exp, 104, doi: 10.3791/53053. (Published).
  • Mourer T, Jacques JF, Brault A, Bisaillon M, Labbe S. (2015). Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe. J Biol Chem, 290(16), 10176-10190. (Published).
  • Rouleau SG, Beaudoin JD, Bisaillon M, Perreault JP. (2015). Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches. Nucleic Acids Res, 43(1), 595-606. (Published).
  • Picard-Jean F, Bouchard S, Larivée G, Bisaillon M. (2014). The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein. Antiviral Res., 111C, 13-22. (Published).
  • Wypijewska del Nogal A , Surleac MD , Kowalska J , Lukaszewicz M , Jemielity J , Bisaillon M , Darzynkiewicz E , Milac AL , Bojarska E. (2013). Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding. The FEBS journal, 280(24), 6508-27. (Published).
  • Issur M , Bougie I , Despins S , Bisaillon M. (2013). Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism. PLoS one, 8(9), e75310. (Published).
  • Picard-Jean F , Bougie I , Shuto S , Bisaillon M. (2013). The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme. PLoS one, 8(1), e54621. (Published).
  • Anderson DE , Castan A , Bisaillon M , von Messling V. (2012). Elements in the canine distemper virus M 3' UTR contribute to control of replication efficiency and virulence. PLoS one, 7(2), e31561. (Published).
  • Lemay G , Bisaillon M. (2012). Further characterization and determination of the single amino acid change in the tsI138 reovirus thermosensitive mutant. Canadian Journal of Microbiology, 58(5), 589-95. (Published).
  • Rouleau SG , Jodoin R , Bisaillon M , Perreault JP. (2012). Programming a highly structured ribozyme into complex allostery using RNA oligonucleotides. ACS chemical biology, 7(11), 1802-6. (Published).
  • Motard J , Rouxel R , Paun A , von Messling V , Bisaillon M , Perreault JP. (2011). A novel ribozyme-based prophylaxis inhibits influenza A virus replication and protects from severe disease. PLoS one, 6(11), e27327. (Published).
  • Dubé A , Bolduc F , Bisaillon M , Perreault JP. (2011). Mapping studies of the Peach latent mosaic viroid reveal novel structural features. Molecular Plant Pathology, 12(7), 688-701. (Published).
  • Issur M , Picard-Jean F , Bisaillon M. (2011). The RNA capping machinery as an anti-infective target. Wiley interdisciplinary reviews. RNA, 2(2), 184-92. (Published).
  • Tremblay-Létourneau M , Despins S , Bougie I , Bisaillon M. (2011). Virtual high-throughput screening identifies mycophenolic acid as a novel RNA capping inhibitor. PLoS one, 6(9), e24806. (Published).
  • Despins S , Issur M , Bougie I , Bisaillon M. (2010). Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase. Nucleic Acids Research, 38(16), 5493-506. (Published).
  • Reymond C , Lévesque D , Bisaillon M , Perreault JP. (2010). Developing three-dimensional models of putative-folding intermediates of the HDV ribozyme. Structure (London, England : 1993), 18(12), 1608-16. (Published).
  • Soulière MF , Perreault JP , Bisaillon M. (2010). Insights into the molecular determinants involved in cap recognition by the vaccinia virus D10 decapping enzyme. Nucleic Acids Research, 38(21), 7599-610. (Published).
  • Dubé A , Baumstark T , Bisaillon M , Perreault JP. (2010). The RNA strands of the plus and minus polarities of peach latent mosaic viroid fold into different structures. RNA (New York, N.Y.), 16(3), 463-73. (Published).
  • Soulière MF , Perreault JP , Bisaillon M. (2009). Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism. The Biochemical journal, 420(1), 27-35. (Published).
  • Dubé A , Bisaillon M , Perreault JP. (2009). Identification of proteins from prunus persica that interact with peach latent mosaic viroid. Journal of virology, 83(23), 12057-67. (Published).
  • Bougie I , Bisaillon M. (2009). Metal ion-binding studies highlight important differences between flaviviral RNA polymerases. Biochimica et biophysica acta, 1794(1), 50-60. (Published).
  • Reymond C , Bisaillon M , Perreault JP. (2009). Monitoring of an RNA multistep folding pathway by isothermal titration calorimetry. Biophysical journal, 96(1), 132-40. (Published).
  • Issur M , Despins S , Bougie I , Bisaillon M. (2009). Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase. Nucleic acids research, 37(11), 3714-22. (Published).
  • Issur M , Geiss BJ , Bougie I , Picard-Jean F , Despins S , Mayette J , Hobdey SE , Bisaillon M. (2009). The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure. RNA (New York, N.Y.), 15(12), 2340-50. (Published).
  • Soulière MF , Perreault JP , Bisaillon M. (2008). Kinetic and thermodynamic characterization of the RNA guanylyltransferase reaction. Biochemistry, 47(12), 3863-74. (Published).
  • Soulière MF , Perreault JP , Bisaillon M. (2008). Magnesium-binding studies reveal fundamental differences between closely related RNA triphosphatases. Nucleic acids research, 36(2), 451-61. (Published).
  • Picard-Jean F , Bougie I , Bisaillon M. (2007). Characterization of the DNA- and dNTP-binding activities of the human cytomegalovirus DNA polymerase catalytic subunit UL54. The Biochemical journal, 407(3), 331-41. (Published).
  • Bougie I , Bisaillon M. (2007). Characterization of the RNA binding energetics of the Candida albicans poly(A) polymerase. Yeast (Chichester, England), 24(5), (Published).
  • Reymond C , Ouellet J , Bisaillon M , Perreault JP. (2007). Examination of the folding pathway of the antigenomic hepatitis delta virus ribozyme reveals key interactions of the L3 loop. RNA (New York, N.Y.), 13(1), (Published).
  • Fillebeen C , Muckenthaler M , Andriopoulos B , Bisaillon M , Mounir Z , Hentze MW , Koromilas AE , Pantopoulos K. (2007). Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells. Journal of hepatology, 47(1), (Published).
  • Benzaghou I , Bougie I , Picard-Jean F , Bisaillon M. (2006). Energetics of RNA binding by the West Nile virus RNA triphosphatase. FEBS letters, 580(3), (Published).
  • Bougie I , Bisaillon M. (2006). Inhibition of a metal-dependent viral RNA triphosphatase by decavanadate. The Biochemical journal, 398(3), (Published).
  • Parent A , Bisaillon M. (2006). [Synergy between transcription and mRNA processing events]. Médecine sciences : M/S, 22(6-7), (Published).
  • Fillebeen C , Rivas-Estilla AM , Bisaillon M , Ponka P , Muckenthaler M , Hentze MW , Koromilas AE , Pantopoulos K. (2005). Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. The Journal of biological chemistry, 280(10), (Published).
  • Yan Y , Svitkin Y , Lee JM , Bisaillon M , Pelletier J. (2005). Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap. RNA (New York, N.Y.), 11(8), (Published).
  • Benzaghou I , Bougie I , Bisaillon M. (2004). Effect of metal ion binding on the structural stability of the hepatitis C virus RNA polymerase. The Journal of biological chemistry, 279(48), (Published).
  • Bougie I , Bisaillon M. (2004). The broad spectrum antiviral nucleoside ribavirin as a substrate for a viral RNA capping enzyme. The Journal of biological chemistry, 279(21), (Published).
  • Bougie I , Parent A , Bisaillon M. (2004). Thermodynamics of ligand binding by the yeast mRNA-capping enzyme reveals different modes of binding. The Biochemical journal, 384(Pt 2), (Published).
  • Bougie I , Charpentier S , Bisaillon M. (2003). Characterization of the metal ion binding properties of the hepatitis C virus RNA polymerase. The Journal of biological chemistry, 278(6), (Published).
  • Bougie I , Bisaillon M. (2003). Initial binding of the broad spectrum antiviral nucleoside ribavirin to the hepatitis C virus RNA polymerase. The Journal of biological chemistry, 278(52), (Published).
  • Bisaillon M , Bougie I. (2003). Investigating the role of metal ions in the catalytic mechanism of the yeast RNA triphosphatase. The Journal of biological chemistry, 278(36), (Published).
  • Bisaillon M , Shuman S. (2001). Functional groups required for the stability of yeast RNA triphosphatase in vitro and in vivo. The Journal of biological chemistry, 276(32), (Published).
  • Bisaillon M , Shuman S. (2001). Structure-function analysis of the active site tunnel of yeast RNA triphosphatase. The Journal of biological chemistry, 276(20), (Published).
  • Bisaillon M , Sénéchal S , Bernier L , Lemay G. (1999). A glycosyl hydrolase activity of mammalian reovirus sigma1 protein can contribute to viral infection through a mucus layer. Journal of molecular biology, 286(3), (Published).
  • Bisaillon M , Lemay G. (1999). Computational sequence analysis of mammalian reovirus proteins. Virus genes, 18(1), (Published).
  • Bisaillon M , Bergeron J , Lemay G. (1997). Characterization of the nucleoside triphosphate phosphohydrolase and helicase activities of the reovirus lambda1 protein. The Journal of biological chemistry, 272(29), (Published).
  • Bisaillon M , Lemay G. (1997). Characterization of the reovirus lambda1 protein RNA 5'-triphosphatase activity. The Journal of biological chemistry, 272(47), (Published).
  • Bisaillon M , Lemay G. (1997). Molecular dissection of the reovirus lambda1 protein nucleic acids binding site. Virus research, 51(2), (Published).
  • Bisaillon M , Lemay G. (1997). Viral and cellular enzymes involved in synthesis of mRNA cap structure. Virology, 236(1), (Published).

Chapitres de livre

  • Picard-Jean F, Tremblay-Létourneau M, Serra E, Dimech C, Schulz H, Anselin M, Dutilly V, Bisaillon M. (2013). RNA 5'-end maturation: a crucial step in the replication of viral genomes. Romanowski V Current issues in molecular virology (27-56). Croatia : InTech. (Published).

Articles de conférence

  • C. Brand, K. Bullard, B. Geiss, M. Bisaillon. (2019). RiboClub 20th Anniversary and Canada Gairdner International Symposium. (Accepted).
  • C. Brand, K. Bullard, B. Geiss, M. Bisaillon. (2019). Changes in host cell gene expression levels and alternative splicing during Flavivirus infections. 69th Annual Conference of the Canadian Society of Microbiologists. (Accepted).
  • C. Brand, K. Bullard, B. Geiss, M. Bisaillon. (2019). Comparaison des changements d’expression des gènes et d’épissage alternatif de la cellule hôte lors d’une infection avec différents Flavivirus. 48e Journée scientifique de la FMSS. (Published).
  • Claudio Jeldres, Sabrina Bouchard, Martin Bisaillon. (2018). Dissecting the expression landscape of genitourinary cancers. American Society of Clinical Society (ASCO) Annual Meeting. (Published).
  • C. Brand, K. Bullard, B. Geiss, M. Bisaillon. (2018). Modulations of the host cell transcriptome upon infection with Kunjin, Zika and Yellow Fever viruses. 31st Annual Canadian Student Health Research Forum. (Published).
  • Claudio Jeldres, Sabrina Bouchard, Martin Bisaillon. (2018). Transcriptome-wide analysis of alternative splicing events in bladder cancer: Novel biomarkers discovery for early diagnosis. American Society of Clinical Society (ASCO) Annual Meeting. (Published).
  • C. Brand, K. Bullard, B. Geiss, M. Bisaillon. (2017). Flaviviruses modulate gene expression and alternative splicing in infected cells. 18th RiboClub Annual Meeting. (Published).
  • C. Brand, K. Votaw, M. McCullagh, B. Geiss, M. Bisaillon. (2016). Characterization of the interaction between the NS3 and NS5 proteins within the West Nile virus replication complex. 19th Annual Chemistry and Biochemistry Graduate Research Conference. (Published).
  • Boudreault S, Thibault P, Durand M, Lapointe E, Lemay G, Bisaillon M. (2016). Reovirus Infection Alters Host Cell Alternative Splicing Landscape. 6th European Congress of Virology (ECV). (Published).
  • C. Brand, K. Votaw, M. McCullagh, B. Geiss, M. Bisaillon. (2016). Study of the West Nile virus RNA replication complex. 17th RiboClub Annual Meeting. (Published).
  • Boudreault S, Thibault P, Durand M, Lapointe E, Garant J-M, Perreault J-P, Scott M, Lemay G, Bisaillon M. (2015). Alternative Splicing Modifications Triggered by Reovirus Infection. Chemistry and Biochemistry Graduate Research Conference (CBGRC). (Published).
  • Boudreault S, Côté S, Lavoie D, Durand M, Lapointe E, Thibault P, Sandekian V, Bisaillon M, Lemay G. (2015). Combination of classical genetics, reverse genetics and transcriptomics to study reovirus'interferon sensitivity and host-cell response. Cytokine 2015 - Symphonies in Health and Disease - Third annual Meeting of the International cytokine and Interferon Society (ICIS). (Published).
  • Rouleau S, Bisaillon M, Perreault JP. (2014). Sequence Specific Modulation of G-Quadruplex Folding. 19th Annual Meeting of the RNA Society. (Published).
  • Jodoin R, Beaudoin JD, Perreault JP, Bisaillon M. (2013). A predictive value optimizing the evaluation of biological RNA G-quadruplexes formation. 18th Annual Meeting of the RNA Society. (Published).
  • Picard-Jean F, Bouchard S, Larivée G, Bisaillon M. (2012). HCV replicon inhibition by the human Lactoferrin is mediated by NS3 ATPase/Helicase inhibition. 19th International Symposium on Hepatitis C Virus and Related Viruses. (Published).
  • Picard-Jean F, Bouchard S, Larivée G, Bisaillon M. (2011). Lactoferrin inhibits the HCV NS3 ATPase/Helicase protein which impairs HCV replicon replication. 18th International Symposium on Hepatitis C Virus and Related Viruses. (Published).
  • Picard-Jean F, Shuto S, Bisaillon, M. (2011). mRNA Capping is Inhibited by the Immunosuppressive Agent Mizoribine Monophosphate. RNA Meeting. (Published).
  • Picard-Jean F, Shuto S, Bisaillon M. (2010). Can mizoribine monophosphate also be an RNA capping inhibitor ?. Gordon research conferences. (Published).
  • Soulière MF, Perreault JP, Bisaillon M. (2010). Cap-recognition Mode of the viral D10 Decapping Enzyme. EMBL Conference: The Complex life of mRNA: from synthesis to decay. EMBL Conference. (Published).
  • Issur M, Despins S, Bougie I, Bisaillon M. (2010). Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase. 24th Annual Symposium of the Protein Society. (Published).
  • Reymond C, Bisaillon M, Perreault JP. (2009). Decipher the folding pathway of a catalytic RNA. RNA Society 14th annual meeting. (Published).
  • Picard-Jean F, Bisaillon M. (2009). Pleiotropic activity of ribavirin on HVC: Ribavirin-triphosphatae can support the NS3-mediated dsRNA unwinding activity. 16th International Symposium on Hepatitis C virus and related viruses. (Published).
  • Dubé A, Baumstark T, Bisaillon M, Perreault JP. (2009). Structural differences between the two RNA strands of peach latent mosaic viroid. American Society for Virology 28th annual meeting. (Published).
  • Soulière M, Perreault JP, Bisaillon M. (2008). Characterization of the vaccinia virus D10 decapping enzyme. RNA 2008. (Published).

Autres contributions

Activités de collaboration internationale

  • Collaborator. (2008-2034). United States. On-going collaboration with Dr Brian Geiss for the study of enzymes involved in the replication of West Nile virus.

Présentations

  • C. Brand, K. Bullard, B. Geiss, M. Bisaillon. (2018). Kunjin, Zika and Yellow Fever viruses differentially alter gene expression and alternative splicing in U87 glioblastoma cells. 37th American Society for Virology Annual Meeting. College Park, MD, United States.
  • C. Brand, K. Bullard, B. Geiss, M. Bisaillon. (2018). Modulations du transcriptome de la cellule hôte suite à l’infection avec le virus Zika. 86e Congrès de l’Acfas. Chicoutimi, Qc, Canada.
  • C. Brand, K. Votaw, M. McCullagh, B. Geiss, M. Bisaillon. (2017). Caractérisation de l’interaction entre les protéines NS3 et NS5 dans le complexe de réplication du virus du Nil occidental. 85e Congrès de l’Acfas. Montréal, Qc, Canada.
  • Sabrina Bouchard, Dominique Dorion, Jean-Pierre-Perreault, Martin Bisaillon. (2017). Focusing on cancer hallmarks: head and neck cancer biomarkers discovery. Journée Phare 2017: Congrès Québécois en sciences de la santé. Bromont, Qc, Canada.
  • C. Brand, K. Bullard, B. Geiss, M. Bisaillon. (2017). Les Flavivirus modulent l’expression des gènes et l’épissage alternatif de leurs cellules hôtes. 9e Journée Phare. Bromont, Qc, Canada.
  • C. Brand, K. Bullard, B. Geiss, M. Bisaillon. (2017). Étude des changements d’expression des gènes et d’épissage alternatif suite à l’infection avec différents Flavivirus. 10e Congrès Armand Frappier. Orford, Qc, Canada.
  • C. Brand, K. Votaw, M. McCullagh, B. Geiss, M. Bisaillon. (2016). L’interaction entre les protéines NS3 et NS5 du virus du Nil occidental - une nouvelle cible pour le développement de composés antiviraux?. 8e Journée Phare. Bromont, Qc, Canada.
  • Simon Boudreault et Martin Bisaillon. (2016). Modulation de l’épissage alternatif de la cellule-hôte lors d’une infection virale. Journée Simon-Pierre Noël 2016 du département de biochimie de l'Université de Montréal. Canada.
  • (2012). La synthèse de la structure coiffe des ARNm représente une cible potentielle pour le développement d’inhibiteurs novateurs. Guest speaker / Seminar series / Dépt. de microbiology et immunologie / Université de Montréal. Montréal, Canada.
  • (2011). RNA Cap Recognition by the Vaccinia Virus D10 Decapping Enzyme. American Society for Microbiology Conference on Viral Genome Replication. Banff, Canada.
  • (2010). Développement d'inhibiteurs contre la synthèse de la structure coiffe des ARNm. Guest speaker / Seminar series / Dépt. de biochimie / Université de Montréal. Montreal, Canada.
  • Moheshwarnath Issur. (2009). Identification of the flaviviral RNA guanylyltransferase involved in the synthesis of the viral RNA cap structure. American Society for Virology 28th annual meeting. Vancouver, Canada.
  • Marie Soulière. (2009). Kinetic and mechanistic characterization of viral capping and decapping enzymes. Guest speaker. Innsbruck, Austria.
  • (2009). Nucleotide analogs and molecular modeling studies to understand enzymes involved in RNA cap synthesis. Guest speaker. Prince George, Canada.
  • (2009). Nucleotide analogs and molecular modeling studies to understand enzymes involved in RNA cap synthesis. Guest speaker. Fort Collins, United States.
  • Marie Soulière. (2009). Two-metal ion mechanism for the vaccinia virus D10 decapping enzyme. American Society for Virology 28th annual meeting. Vancouver, Canada.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.