Présentation

Sujets de recherche

Neurodegenerative Diseases, Neuronal and Synaptic Activity, Neuronal Communication and Neurotransmission, Visual System.

Disciplines de recherche

Neurosciences.

Mots-clés

EEG, Neurophysiology, Signal processing.

Intérêts de recherche

Simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (FMRI) in humans

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Financement

Grant. (Awarded). Principal Applicant. Natural Sciences and Engineering Research Council of Canada (NSERC). (2018-2023).

Grant. (Completed). Co-applicant. Focused ultrasound stimulation for brain research. (2017-2018).

Grant. (Completed). Co-applicant. Multichannel neural signal recording instrumentation for the central auditory system. (2016-2017).

Publications

Articles de revue

• Léveillé- P , Hamel M , Ardilouze JL , Pasquier JC , Deacon C , Whittingstall K , Plourde M. (2018). Pilot study of EEG in neonates born to mothers with gestational diabetes mellitus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 66, 37-44. (Published).
• Savoie, F-A and Th{\'e}nault, F and Whittingstall, K and Bernier, P-M. (2018). Visuomotor Prediction Errors Modulate EEG Activity Over Parietal Cortex. Scientific reports, 8(1), 12513.
• Chamberland M* , Scherrer B , Prabhu SP , Madsen J , Fortin D , Whittingstall K , Descoteaux M , Warfield SK. (2017). Active delineation of Meyer's loop using oriented priors through MAGNEtic tractography (MAGNET). Human brain mapping, 38(1), 509-527. (Published).
• Butler R* , Gilbert G , Descoteaux M , Bernier PM , Whittingstall K. (2017). Application of polymer sensitive MRI sequence to localization of EEG electrodes. Journal of neuroscience methods, 278, 36-45. (Published).
• Girard G* , Daducci A , Petit L , Thiran JP , Whittingstall K , Deriche R , Wassermann D , Descoteaux M. (2017). AxTract: Toward microstructure informed tractography. Human brain mapping, 38(11), 5485-5500. (Published).
• Russell Butler*, Pierre-Michel Bernier, Jérémie Lefebvre, Guillaume Gilbert, Kevin Whittingstall. (2017). Decorrelated Input Dissociates Narrow Band y Power and BOLD in Human Visual Cortex. J Neurosci, 37(22), 5408-5418. (Published).
• Bernier PM, Whittingstall K, Grafton ST. (2017). Differential Recruitment of Parietal Cortex during Spatial and Non-spatial Reach Planning. Frontiers in Human Neuroscience, 5, 5-6. (Published).
• Ledoux LP* , Morency FC , Cousineau M , Houde JC , Whittingstall K , Descoteaux M. (2017). Fiberweb: Diffusion Visualization and Processing in the Browser. Frontiers in neuroinformatics, 11, 54. (Published).
• Chamberland M* , Girard G , Bernier M* , Fortin D , Descoteaux M , Whittingstall K. (2017). On the Origin of Individual Functional Connectivity Variability: The Role of White Matter Architecture. Brain connectivity, 7(8), 491-503. (Published).
• Bernier M* , Croteau E , Castellano CA , Cunnane SC , Whittingstall K. (2017). Spatial distribution of resting-state BOLD regional homogeneity as a predictor of brain glucose uptake: A study in healthy aging. NeuroImage, 150, 14-22. (Published).
• Bizeau A* , Gilbert G , Bernier M* , Huynh MT , Bocti C , Descoteaux M , Whittingstall K. (2017). Stimulus-evoked changes in cerebral vessel diameter: A study in healthy humans. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 5, 271678X17701948. (Published).
• Provencher D* , Bizeau A* , Gilbert G , Bérubé-Lauzière Y , Whittingstall K. (2017). Structural impacts on the timing and amplitude of the negative BOLD response. Magnetic resonance imaging, 45, 34-42. (Published).
• Lagueux É, Bernier M, Bourgault P, Whittingstall K, Mercier C, Léonard G, Laroche S, Tousignant-Laflamme Y. (2017). The Effectiveness of Transcranial Direct Current Stimulation as an Add on Modality to Graded Motor Imagery for Treatment of Complex Regional Pain Syndrome: A Randomized Proof of Concept Study. Clinical Journal of Pain, 6(6), 8-9. (Published).
• Lafleur LP , Tremblay S , Whittingstall K , Lepage JF. (2016). Assessment of Effective Connectivity and Plasticity With Dual-Coil Transcranial Magnetic Stimulation. Brain stimulation, 9(3), 347-55. (Published).
• Benazet M , Thénault F , Whittingstall K , Bernier PM. (2016). Attenuation of visual reafferent signals in the parietal cortex during voluntary movement. Journal of neurophysiology, 116(4), 1831-1839. (Published).
• Provencher D* , Hennebelle M , Cunnane SC , Bérubé-Lauzière Y , Whittingstall K. (2016). Cortical Thinning in Healthy Aging Correlates with Larger Motor-Evoked EEG Desynchronization. Frontiers in aging neuroscience, 8, 63. (Published).
• Hamel-Thibault A , Thénault F , Whittingstall K , Bernier PM. (2016). Delta-Band Oscillations in Motor Regions Predict Hand Selection for Reaching. Cerebral cortex (New York, N.Y. : 1991), 9(8-9), 7-9. (Published).
• Ghumman S* , Fortin D , Noel-Lamy M , Cunnane SC , Whittingstall K. (2016). Exploratory study of the effect of brain tumors on the default mode network. Journal of neuro-oncology, na, na. (Accepted).
• Léveillé P , Ardilouze JL , Pasquier JC , Deacon C , Whittingstall K , Plourde M. (2016). Fatty acid profile in cord blood of neonates born to optimally controlled gestational diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids, 115, 48-52. (Published).
• Bernier M* , Gauvreau C* , Theriault D , Madrolle S , Lepage JF , Whittingstall K. (2016). Increased BOLD activation in the left parahippocampal cortex after 1 year of medical school: an association with cumulative verbal memory learning. Neuroreport, 27(1), 45-9. (Published).
• Renauld E* , Descoteaux M , Bernier M*, Garyfallidis E , Whittingstall K. (2016). Semi-Automatic Segmentation of Optic Radiations and LGN, and Their Relationship to EEG Alpha Waves. PloS one, 11(7), e0156436. (Published).
• Constanzo J , Masson-Côté L , Tremblay L , Fouquet JP , Sarret P , Geha S , Whittingstall K , Paquette B , Lepage M. (2016). Understanding the continuum of radionecrosis and vascular disorders in the brain following gamma knife irradiation: An MRI study. Magnetic resonance in medicine, 4, 5-6. (Published).
• Tax CM , Chamberland M* , van Stralen M , Viergever MA , Whittingstall K , Fortin D , Descoteaux M , Leemans A. (2015). Seeing More by Showing Less: Orientation-Dependent Transparency Rendering for Fiber Tractography Visualization. PloS one, 10(10), e0139434. (Published).
• Dufort Rouleau R , Lagrandeur L , Daigle K , Lorrain D , Léonard G , Whittingstall K , Goffaux P. (2015). Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2, 1-8. (Published).
• Lefebvre J, Hutt A, Knebel JF, Whittingstall K, Murray M. (2015). Stimulus statistics shape oscillations in non-linear recurrent neural networks. Journal of Neuroscience, 7, 2895-903. (In Press).
• Zaldivar D, Rauch A, Whittingstall K, Logothetis N, Goense J. (2014). Dopamine-induced dissociation of BOLD- and neural activity in macaque visual cortex. Current Biology, 23, 2805-11. (In Press).
• Musall S* , von Pföstl V , Rauch A , Logothetis NK , Whittingstall K. (2014). Effects of neural synchrony on surface EEG. Cerebral cortex (New York, N.Y. : 1991), 24(4), 1045-53. (Published).
• Nugent S , Castellano CA , Goffaux P , Whittingstall K , Lepage M , Paquet N , Bocti C , Fulop T , Cunnane SC. (2014). Glucose hypometabolism is highly localized but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults. American journal of physiology. Endocrinology and metabolism, 11, E1315-21. (Accepted).
• Goffaux P , Girard-Tremblay L , Marchand S , Daigle K , Whittingstall K. (2014). Individual differences in pain sensitivity vary as a function of precuneus reactivity. Brain topography, 27(3), 366-74. (Published).
• Chamberland M* , Whittingstall K , Fortin D , Mathieu D , Descoteaux M. (2014). Real-time multi-peak tractography for instantaneous connectivity display. Frontiers in neuroinformatics, 8, 59. (Published).
• Vigneau-Roy N* , Bernier M* , Descoteaux M , Whittingstall K. (2014). Regional variations in vascular density correlate with resting-state and task-evoked blood oxygen level-dependent signal amplitude. Human brain mapping, 35(5), 1906-20. (Published).
• Girard-Tremblay L , Auclair V , Daigle K , Léonard G , Whittingstall K , Goffaux P. (2014). Sex differences in the neural representation of pain unpleasantness. The journal of pain : official journal of the American Pain Society, 15(8), 867-77. (Published).
• Whittingstall K , Bernier M* , Houde JC , Fortin D , Descoteaux M. (2014). Structural network underlying visuospatial imagery in humans. Cortex; a journal devoted to the study of the nervous system and behavior, 56, 85-98. (Published).
• Girard G* , Whittingstall K , Deriche R , Descoteaux M. (2014). Towards quantitative connectivity analysis: reducing tractography biases. NeuroImage, 98, 266-78. (Published).
• Bernier M* , Chamberland M* , Houde JC , Descoteaux M , Whittingstall K. (2014). Using fMRI non-local means denoising to uncover activation in sub-cortical structures at 1.5 T for guided HARDI tractography. Frontiers in human neuroscience, 8, 715. (Published).
• Fortin D , Aubin-Lemay C , Boré A , Girard G , Houde JC , Whittingstall K , Descoteaux M. (2012). Tractography in the study of the human brain: a neurosurgical perspective. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 39(6), 747-56. (Published).
• Reichenbach A , Whittingstall K , Thielscher A. (2011). Effects of transcranial magnetic stimulation on visual evoked potentials in a visual suppression task. NeuroImage, 54(2), 1375-84. (Published).
• Whittingstall K , Bartels A , Singh V , Kwon S , Logothetis NK. (2010). Integration of EEG source imaging and fMRI during continuous viewing of natural movies. Magnetic resonance imaging, 28(8), 1135-42. (Published).
• Mazzoni A , Whittingstall K , Brunel N , Logothetis NK , Panzeri S. (2010). Understanding the relationships between spike rate and delta/gamma frequency bands of LFPs and EEGs using a local cortical network model. NeuroImage, 52(3), 956-72. (Published).

Chapitres de livre

• Louis Lemieux, Kevin Whittingstall and Kamil Uludag. (2015). Combining fMRI with Other Modalities: Multimodal Neuroimaging. fMRI: From nuclear spins to brain functions (330-345). Springer. (Published).
• Kevin Whittingstall and Nikos Logothetis. (2013). Physiological foundations of neural signals. Principles of Neural Coding (1-20). CRC Press. (Published).

Articles de conférence

• Bernier M*, Croteau E, Castellano C, Cunnane SC, Whittingstall K. (2016). Resting-state BOLD local synchrony as a strong proxy of glucose uptake and as a biomarker of aging using functionally-driven gray matter parcelization. International Society for Magnetic Resonance in Medicine (ISMRM). (Accepted).
• Provencher D*, Bartels A, Bérubé-Lauzière Y, Whittingstall K. (2015). Failure of the "standard" fMRI analysis in the visual cortex using a smooth visual stimulus. International Society for Magnetic Resonance in Medicine. (Accepted).
• Chamberland M*, Bernier M*, Fortin D, Whittingstall K and Descoteaux M. (2015). Interactively computing and visualizing functional and structural brain connectivity in real-time. International Society of Magnetic Resonance in Medecine (ISMRM). (Accepted).
• Provencher D*, Bernier M, Cunnane C, Bérubé-Lauzière Y, Whttingstall K. (2015). Investigation of anatomical confounds in EEG signal modulation. Human Brain Mapping. (Accepted).
• Bernier M*, Croteau E, Castellano C-A, Chamberland M, Provencher D, Cunnane S, Whittingstall K. (2015). Resting-state BOLD amplitude (ALFF) is a poor predictor of PET-FDG measure of glucose metabolism. Human Brain Mapping. (Accepted).
• Butler R*, Bernier PM, Whittingstall K. (2015). Simple Stimulus Manipulation Decouples Gamma Power and BOLD in Human V1. Human Brain Mapping. (Accepted).
• Girard G*, Whittingstall K, Deriche R, Descoteaux M. (2015). Structural connectivity reproducibility through multiple acquisitions. Human Brain Mapping. (Accepted).
• Girard G*, Whittingstall K, Deriche R, Descoteaux M. (2015). Studying white matter tractography reproducibility through connectivity matrices. International Symposium on Magnetic Resonance in Medicine. (Accepted).
• Chamberland M*, Bernier M*, Fortin D, Descoteaux M, Whittingstall K. (2015). Tractography-driven resting-state fMRI for investigating inter-subject variability. OHBM 2015. (Accepted).
• Bernier M*, Chamberland M, Castellano C-A, Cunnane S, Whittingstall K. (2015). Uncovering sub-cortical functinal networks involving deep-brain structures using Non-Local Means denoising at 1.5T. International Society for Magnetic Resonance in Medecine. (Accepted).
• Renauld E*, Descoteaux M, Whittingstall K. (2014). An EEG/MRI-dMRI study: Structural properties of the thalamus and its influence on human alpha waves. Human Brain Mapping. (Accepted).
• Girard G*, Whittingstall K, Deriche R, Descoteaux M. (2014). Choosing Tractography Parameters to Improve Connectivity Mapping. International Symposium on Magnetic Resonance in Medicine (ISMRM). (Accepted).
• Girard G*, Whittingstall K, Descoteaux M. (2014). Connectivity directionally-encoded color map: a streamline-based color mapping. Human Brain Mapping. (Accepted).
• Trottier-Duclos F*, Bourgalt P, Whittingstall K. (2014). Effect of corpus callosum on task-related beta power modulation. Human Brain Mapping. (Accepted).
• Bernier M*, Whittingstall K. (2014). FMRI denoising using non-local means to uncover activation in sub-cortical structures at 1.5T. Human Brain Mapping. (Accepted).
• Provencher D*, Bartels A, Bérubé-Lauzière Y, Whittingstall K. (2014). Hemodynamic response function estimation in the visual cortex during sinusoidal visual stimuli. Human Brain Mapping. (Accepted).
• Hutt A, Whittingstall K, Lefebvre J*, Murray M. (2014). Stochastic Modulation of Oscillatory Neural Activity. Organization for Computational Neuroscience (CNS). (Accepted).
• Thompson J, Whittingstall K, Vigneau-Roy N*, Warsi M, Noseworthy M. (2014). Study of Cerebral Venous Density in Alzheiner's Disease using Susceptibility Weighted Magnetic Resonance Imaging. International Symposium on Magnetic Resonance in Medicine (ISMRM). (Accepted).
• Chamberland M*, Bernier M, Fortin D, Descoteaux M, Whittingstall K. (2014). Uncovering a visuospatial network at rest. Human Brain Mapping. (Accepted).
• Whittingstall K, Vigneau-Roy N*, Bernier M, Descoteaux M. (2013). A toolbox for automatically segmenting cortical vessels from MRI. Society for Neuroscience (SFN). (Accepted).
• Bernier M, Gaudreau D, Thenault F, Gagne ME, Whittingstall K. (2013). Neural correlates of visuo-proprioceptive integration for online movement control. Society for Neuroscience (SFN). (Accepted).
• Bernier M*, Whittingstall K. (2012). Functional connectivity of fMRI activation clusters projected in resting state-space. Organization for Human Brain Mapping. (Accepted).
• Vigneau-Roy N*, Bernier M*, Descoteaux M, Whittingstall K. (2012). Link between function and structure in the resting-state brain; an fMRI and VBM study. Organization for Human Brain Mapping. (Accepted).
• Goffaux P, Rainville P, Marchand S, Girard-Tremblay L, Whittingstall K. (2012). Predicting induvidual differences in sensitivity to pain: a role for the precuneus. Annual Scientific Meeting of the American Pain Society. (Accepted).
• Zaldivar D*, Li J, vPföstl V, Whittingstall K, Goense J, Logothetis NK, Rauch A. (2012). The modulatory role of dopamine in the early visual system of macaques investigated by fMRI, neurochemistry and neurophysiology. Federation of European Neurosciences. (Accepted).
• Descoteaux M, Fortin D, Whittingstall K. (2011). DTI/fMRI fusion at 1.5T confirms robust relationship between structural and functional connectivity in a glioma patient. ISMRM Mapping Functional Networks for Brain Surgery Workshop. (Accepted).

Autres contributions

Gestion d'évènements

• Member of Organization Committee. (2017). Medical Image Computing and Computer Assisted Interventions. (Conference).

Présentations

• (2017). Couplage Neurovasculaire chez L'humain. Club de Recherches Cliniques du Québec (CRCQ). Canada.
• (2016). Imaging Human Cerebral Vaculature. Quebec Bio-Imaging Network Scientific Symposium: Super-Big Brain. Canada.
• (2016). Neurovascular Coupling in the Human Brain. Invited Presentation. Canada.
• (2015). Neurovascular Coupling in the Human Brain. Invited Presentation. Vancouver, Canada.
• (2014). EEG: Basic principles and interpretation. Invited Presentation. Canada.
• (2014). Neurovascular Coupling in the Human Brain. Quebec Bio-Imaging Network Scientific Research Day. Canada.
• (2014). Neurovascular Coupling in the Human Brain. Invited Presentation. France.
• (2014). Neurovascular Coupling in the Human Brain. Invited Presentation. Netherlands.
• (2013). Neurovascular Coupling in the Human Brain. Invited Presentation. Canada.
• (2013). Neurovascular Coupling in the Human Brain. Invited Presentation. Canada.
• (2013). Neurovascular Coupling in the Human Brain. Invited Presentation. Canada.
• (2013). Neurovascular Coupling in the Human Brain. Invited Presentation. Canada.
• (2012). Neurovascular Coupling in the Human Brain. Invited presentation:. France.