Présentation

Sujets de recherche

Cell Signaling and Cancer, Biological and Biochemical Mechanisms, Carcinogenesis, Digestive System, Host-Tumour Interaction.

Disciplines de recherche

Oncology, Cell Biology.

Mots-clés

Cancer, Receptor Tyrosine Kinase, Cell Signaling, Angiogenesis, Tumorigenesis, Metastasis, Cancer Mouse Models, Colorectal cancer, Inflammatory bowel disease.

Intérêts de recherche

My research interest is to understand the molecular signaling events and biological processes regulated by growth factor receptor tyrosine kinases contributing to the initiation and progression of cancer.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

• (2014) RECMUS Award Nomination. Université de Sherbrooke. (Distinction).
• (2012) FRSQ Research Salary Award Senior. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
• (2011) FRSQ Research Salary Award Junior 2. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
• Member of CIHR College of Reviewers. Canadian Institute for Health Research. (Distinction).

Financement

Grant. (Awarded). Principal Investigator. Epithelial cell-specific role of SOCS1 in prevention of intestinal inflammation. Canadian Institutes of Health Research (CIHR). Project Grant. 787950 $ (2019-2024).

Grant. (Awarded). Principal Applicant. Non-canonical role of initiator caspases in colorectal cancer. Canadian Institutes of Health Research (CIHR). Project Grant. 669375 $ (2019-2024).

Grant. (Awarded). Principal Investigator. MET and p66SHC interactomes and functions. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grant. 130000 $ (2017-2022).

Grant. (Completed). Co-applicant. CIACCO-2019 (8th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity). Canadian Institutes of Health Research (CIHR). Planning and Dissemination Grant. 10000 $ (2018-2019).

Grant. (Completed). Principal Applicant. Rôle oncogénique des caspases. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Programme d’aide au financement interne. 10000 $ (2018-2019).

Grant. (Completed). Principal Applicant. Développement d’anticorps spécifiques aux formes clivées par les caspases initiatrices de sortin nexin 1 et 2. Centre de protéomique structurale et fonctionnelle des protéomes de l’Université de Sherbrooke. Projets collaboratifs PROTEOMEUS. 8000 $ (2018-2019).

Grant. (Completed). Principal Applicant. Rôle intrinsèque de SOCS1 dans l’épithélium intestinal et l'inflammation. Centre de recherche en inflammation et oncologie digestive de l’UdeS. Operating Grant. 15000 $ (2017-2018).

Grant. (Completed). Co-applicant. Blocking Molecular Movement of the NHE6 Exchanger Could Lead to New Way to Treat Breast Cancer. (2015-2016).

Grant. (Completed). Principal Investigator. Impact de la délétion de SOCS1 dans l’épithélium intestinal. (2013-2015).

Grant. (Completed). Principal Investigator. Role of Receptor Tyrosine Kinases in the Initiation and Progression of Colorectal Cancer. Canadian Institutes of Health Research (CIHR). Operating Grant. 657990 $ (2010-2015).

Grant. (Completed). Principal Investigator. Évaluation pré-clinique de l'effet préventif et thérapeutique de monoglycérides dérivés d'oméga-3 dans le cancer colorectal. (2011-2013).

Grant. (Completed). Co-investigator. Regulation of Met Signaling by Socs1 in Hepatocellular Carcinoma. (2011-2013).

Grant. (Completed). Principal Investigator. The Role of Met Receptor in Morphogenesis and Renewal of the Intestinal Epithelium. (2008-2013).

Grant. (Completed). Principal Investigator. Évaluation comparative des propriétés biologiques des monoglycérides de DHA et EPA dans le cancer colorectale. (2011).

Grant. (Completed). Co-investigator. Wake up of Dormant Metastatic Breast Cancer Cells by Radiation: Prevention with a COX-2 Inhibitor. (2010-2011).

Grant. (Completed). Co-applicant. Colloque "Signalisation Québec 2010". (2010).

Grant. (Completed). Principal Investigator. Role of Shc in the Development and Progression of Colorectal Cancer. (2007-2010).

Grant. (Completed). Principal Applicant. Étude des mécanismes moléculaires et cellulaires impliqués dans les physiopathologies de l'épithélium intestinal. (2008-2009).

Grant. (Completed). Principal Applicant. Étude des mécanismes moléculaires et cellulaires impliqués dans les physiopathologies de l'épithélium intestinal. (2008-2009).

Grant. (Completed). Principal Investigator. The Role of Met Receptor in Morphogenesis and Renewal of the Intestinal Epithelium. (2007-2008).

Grant. (Completed). Co-applicant. Shc in Breast Tumor Angiogenesis. (2005-2008).

Publications

Articles de revue

• PLEASE take note:. (2020). * identifies students or PDF under my supervision and ¶ research professionals. N/A, N/A(N/A), NA. (Accepted).
• Harper K, Brochu-Gaudreau K , SAUCIER C, Dubois CM. (2019). Hypoxia Downregulates LPP3 and Promotes the Spatial Segregation of ATX and LPP1 During Cancer Cell Invasion. Cancers, (Revision Requested).
• *Gui Y, Khan MGM, Bobbala D, Dubois C, Ramanathan S, SAUCIER C and Ilangumaran S (Co-Senior Author). (2017). Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1. World J. Gastroenterol., 23(36), 6639-6649. (Published).
• Duclos CM, *Champagne A, Carrier JC, SAUCIER C, Lavoie CL, Denault JB. (2017). Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell death discovery, 3, 16100. (Published).
• Duclos CM, *Champagne A, Carrier JC, SAUCIER C, Lavoie CL, Denault JB. (2017). Caspases play in traffic. Cell death & disease (partly funded by CIHR grant to CS), 8(3), e2636. (Published).
• Chevrier M , Bobbala D , Villalobos-Hernandez A , Khan MG , Ramanathan S , SAUCIER C , Ferbeyre G , Geha S , Ilangumaran S. (2017). Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer. BMC cancer, 17(1), 157. (Published).
• *Bouchard G, Therriault H, Bujold R, SAUCIER C, Paquette B. (2017). Induction of interleulin-1? by mouse mammary tumor irradiation promotes triple negative breast cancer cells invasion and metastasis development. International journal of radiation biology, 93(5), 507-516. (Published).
• *Bouchard G , Therriault H , Geha S , Bujold R , SAUCIER C , Paquette B. (2017). Radiation-induced lung metastasis development is MT1-MMP-dependent in a triple-negative breast cancer mouse model. British journal of cancer, 116(4), 479-488. (Published).
• Villalobos-Hernandez A, Bobbala D, Kandhi R, Khan MG, Mayhue M, Dubois CM, Ferbeyre G, SAUCIER C, Ramanathan S, Ilangumaran S. (2017). SOCS1 inhibits migration and invasion of prostate cancer cells, attenuates tumor growth and modulates the tumor stroma. Prostate cancer and prostatic diseases, 20(1), 36-47. (Published).
• Rodriguez GM, Bobbala D, Serrano D, Mayhue M, *Champagne A, SAUCIER C, Steimle V, Kufer TA, Menendez A, Ramanathan S, Ilangumaran S. (2016). NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8(+) T lymphocytes. Oncoimmunology, 5(6), e1151593. (Published).
• *Landry M , ¶Pomerleau V , SAUCIER C (Senior Author). (2016). Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor. The Biochemical journal, 473(11), 1617-27. (Published).
• *Beaurivage C, *Champagne A, *Tobelaim WS, ¶Pomerleau V, Menendez A, SAUCIER C (Senior Author). (2016). SOCS1 in cancer: An oncogene and a tumor suppressor. Cytokine, 82, 87-94. (Published).
• *Bouchard G, Therriault H, Geha S, Bérubé-Lauzière Y, Bujold R, SAUCIER C, Paquette B. (2016). Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model. BMC Cancer, 16(361), 1-14. (Published).
• *Bouchard G, Therriault H, Geha S, Bérubé-Lauzière Y, Bujold R, SAUCIER C, Paquette B. (2016). Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model. BMC cancer, 16, 361. (Published).
• Yeganeh M, *Gui Y, Kandhi R, Bobbala D, *Tobelaim WS, SAUCIER C, Yoshimura A, Ferbeyre G, Ramanathan S, Ilangumaran S. (2016). Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21(CIP1/WAF1) in the liver. Oncogene, 35(32), 4200-11. (Published).
• *Gui Y, Yeganeh M, Cepero-Donates Y, *Tobelaim WS, ¶Chababi W, Mayhue M, Yoshimura A, Ramanathan S, Yoshimura A, SAUCIER C, Ilangumaran S (Co-Senior Author). (2015). Regulation of MET receptor tyrosine kinase signaling by suppressor of cytokine signaling 1 (SOCS1) in hepatocellular carcinoma. Oncogene, 34, 5718-28. (Published).
• *Tobelaim S, *Beaurivage C, *Champagne A, ¶Pomerleau V, ¶Simoneau A, ¶Chababi W, Yeganeh M, Thibault P, Klinck R, Carrier JC, Ferbeyre G, Ilangumaran S, SAUCIER C (Senior Author). (2015). Tumor-promoting role of SOCS1 in colorectal cancer cells. Scientific Reports, 5, 1-13. (Published).
• ¶Pomerleau V, *Landry M, *Bernier J, Vachon PH, SAUCIER C (Senior Author). (2014). Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions. BMC Cancer, 14, 1-15. (Published).
• *Gui Y, Yeganeh M, Cepero-Donates Y, Ramanathan S, SAUCIER C, Ilangumaran S. (2014). Regulation of MET Receptor Signaling by SOCS1 and its Implications for Hepatocellular Carcinoma. Current Pharmaceutical Design, 20(17), 2922-2933. (Published).
• Haines E, SAUCIER C, Claing A. (2014). The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells. Journal of Biological Chemistry, 289(9), 5687-703. (Published).
• *Bouchard G, Bouvette G, Therriault H, Bujold R, SAUCIER C, Paquette B. (2013). Pre-irradiation of mouse mammary gland stimulates cancer cell migration and development of lung metastases. British Journal of Cancer, 109(7), 1829-38. (Published).
• *Gui Y, Yeganeh M, Ramanathan S, Leblanc C, ¶Pomerleau V, Ferbeyre G, SAUCIER C, Ilangumaran S. (2011). SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes. Journal of Hepatology, 55(6), 1300-8. (Published).
• *Bernier J, *Chababi W, ¶Pomerleau V, SAUCIER C (Senior Author). (2010). Oncogenic engagement of the Met receptor is sufficient to evoke angiogenic, tumorigenic, and metastatic activities in rat intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology, 299(3), G677-86. (Published).
• Langlois MJ, Bergeron S, Bernatchez G, Boudreau F, SAUCIER C, Perreault N, Carrier JC, Rivard N. (2010). The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PloS One, 5(12), 1-12. (Published).
• Lemieux E, Bergeron S, Durand V, Asselin C, SAUCIER C, Rivard N. (2009). Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis. International journal of cancer. Journal international du cancer, 125(7), 1575-86. (Published).
• Seiden-Long I , Navab R , Shih W , Li M , Chow J , Zhu CQ , Radulovich N , SAUCIER C , Tsao MS. (2008). Gab1 but not Grb2 mediates tumor progression in Met overexpressing colorectal cancer cells. Carcinogenesis, 29(3), 647-55.
• ‡Mood K , ‡SAUCIER C , Bong YS , Lee HS , Park M , Daar IO (‡co-first author). (2006). Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor. Molecular biology of the cell, 17(9), 3717-28.
• ‡Mood K , ‡SAUCIER C , Ishimura A , Bong YS , Lee HS , Park M , Daar IO (‡co-first author). (2006). Oncogenic Met receptor induces cell-cycle progression in Xenopus oocytes independent of direct Grb2 and Shc binding or Mos synthesis, but requires phosphatidylinositol 3-kinase and Raf signaling. Journal of cellular physiology, 207(1), 271-85.
• Ishimura A , Lee HS , Bong YS , SAUCIER C , Mood K , Park EK , Daar IO. (2006). Oncogenic Met receptor induces ectopic structures in Xenopus embryos. Oncogene, 25(31), 4286-99.
• Abella JV , Peschard P , Naujokas MA , Lin T , SAUCIER C , Urbé S , Park M. (2005). Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Molecular and cellular biology, 25(21), 9632-45.
• SAUCIER C , Khoury H , Lai KM , Peschard P , Dankort D , Naujokas MA , Holash J , Yancopoulos GD , Muller WJ , Pawson T , Park M. (2004). The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 101(8), 2345-50. (Published).
• Lock LS , Frigault MM , SAUCIER C , Park M. (2003). Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain. The Journal of biological chemistry, 278(32), 30083-90.
• SAUCIER C , Papavasiliou V , Palazzo A , Naujokas MA , Kremer R , Park M. (2002). Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis. Oncogene, 21(12), 1800-11.
• SAUCIER C , Morris SJ , Albert PR. (1998). Endogenous serotonin-2A and -2C receptors in Balb/c-3T3 cells revealed in serotonin-free medium: desensitization and down-regulation by serotonin. Biochemical pharmacology, 56(10), 1347-57.
• SAUCIER C , Albert PR. (1997). Identification of an endogenous 5-hydroxytryptamine2A receptor in NIH-3T3 cells: agonist-induced down-regulation involves decreases in receptor RNA and number. Journal of neurochemistry, 68(5), 1998-2011.
• Albert PR , Lembo P , Storring JM , Charest A , SAUCIER C. (1996). The 5-HT1A receptor: signaling, desensitization, and gene transcription. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 14(1), 19-25.

Chapitres de livre

• McManus S*, Chababi W*, Arsenault D, Dubois CM and SAUCIER C (Senior Author). (2018). Dissecting Oncogenic RTK Pathways in Colorectal Cancer Initiation and Progression. Beaulieu J.-F. Colorectal Cancer: Methods and Protocols (1765, 2742). United States : Springer. (Published).
• SAUCIER C, Rivard N. (Co-Senior Author). (2010). Epithelial cell signalling in colorectal cancer metastasis. Beauchemin N, Huot J Metastasis of Colorectal Cancer (205-241). Netherlands : Springer. (Published).

Autres contributions

Cours enseignés

• Prolifération cellulaire et cancer. BCL 602. (2020-01-10). Niveau : Undergraduate.
• Cytophysiologie – Mécanismes de transmission des signaux. BCL 106. (2019-09-01). Niveau : Undergraduate.
• Projet de recherche en médecine II. MSP266. (2019-01-10). Niveau : Undergraduate.
• Le microbiome dans la physiologie, l'immunologie et le métabolisme de l'hôte – Le microbiome dans le cancer. MCR 717. (2018-01-09). Niveau : Graduate.
• Biologie Cellulaire – Signalisation cellulaire. BCL 726. (2017-01-02). Niveau : Graduate.
• Cytokines – Les facteurs de croissance et les récepteurs des tyrosines kinases. IML 701. (2016-03-03). Niveau : Graduate.
• Pharmacologie moléculaire : Cibles pharmacologiques – kinases à Tyr. PHR 501. (2014-03-21). Niveau : Undergraduate.
• Biologie moléculaire et cellulaire du cancer. BCL 735. (2013-09-02). Niveau : Graduate.
• Signalisation intracellulaire. BCL 740. (2008-05-01). Niveau : Graduate.

Gestion d'évènements

• Organizing Committee Member. (2019). 2e Colloque de biologie cellulaire. (Conference).
• Organizing Committee Member. (2019). 8th Annual Symposium on Cytokine in Inflammation, Ageing, Cancer and Obesity (CIACCO). (Conference).
• Organizing Committee Member. (2018). 7th Annual Symposium on Cytokine in Inflammation, Ageing, Cancer and Obesity (CIACCO). (Conference).
• Organizing Committee Member. (2017). 6th Annual Symposium on Cytokine in Inflammation, Ageing, Cancer and Obesity (CIACCO). (Conference).
• Organizing Committee Member. (2016). 5th Annual Symposium on Cytokine in Inflammation, Ageing, Cancer and Obesity (CIACCO). (Conference).
• Organizing Committee Member. (2015). 4th Annual Symposium on Cytokines in Inflammation, Ageing, Cancer and Obesity (CIACCO). (Conference).
• Coordinator. (2011-2014). Conference & Seminar Series, Department of Anatomy and Cell Biology & Program of Cell Biology, Université de Sherbrooke. (Seminar).
• Organizing Committee Member. (2014). 3rd Annula Symposium on Cytokines in Inflammation, Ageing, Cancer and Obesity (CIACCO). (Conference).
• Organizing Committee Member. (2010). Colloque “Signalisation Québec 2010". (Conference).