Amrani, Abdelaziz

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pédiatrie

Coordonnées

Courriel


819-821-8000, poste 14854

Diplômes

(2001) Postdoctorat. The University of Calgary.

(1996) Postdoctorat. The University of Calgary.

(1995) Doctorat. Université de Paris VI (P & M Curie).

(1992) Maîtrise avec mémoire. Université de Paris VI (P & M Curie).

Présentation

Sujets de recherche

Système immunitaire, Maladies du système immunitaire, Immunothérapie.

Disciplines de recherche

Immunologie, Biologie cellulaire.

Mots-clés

Autoimmunité, Cellules dendritiques, Cytométrie de flux, Diabète de type 1, Lymphocytes T, Lymphocytes T régulateurs, RT-PCR, ELISA, Souris transgéniques, Test de cytotoxicité, tests de prolifération.

Intérêts de recherche

Étude des mécanismes cellulaires et moléculaires par lesquels les cellules dendritiques induisent la tolérance des lymphocytes T dans les maladies autoimmunes.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Financement

Subvention. (Obtenu). Demandeur principal. Molecular signaling in the regulation of dendritic cell function. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Discovery Grant. 150000 $ (2015-2020).

Publications

Articles de revue

  • Gharagozloo M, Mahmoud S, Simard C, Yamamoto K, Bobbala D, Ilangumaran S, Lamontagne A, Jarjoura S, Denault JB, Blais V, Gendron L, Vilariño-Güell C, Sadovnick AD, Ting JP, Amrani , and Gris D. (2019). PLos Biology, 17(9), 1 - 30. DOI. (Article publié).
  • Zerif E* , Gris D, Dupis G and Amrani A. (2019). Constitutively Active Stat5b Drives dendritic cells Tolerogenic Status Through Ezh2 dependent regulation of IRF4 and IRF8 in NOD mice. Plos Biology, NA(NA), NA. (Article soumis).
  • Marjan Gharagozloo, Katsiaryna V. Gris, Tara Mahvelati, Abdelaziz Amrani, John R. Lukens and Denis Gris. (2018). NLR-Dependent Regulation of inflammation in Multiple Sclerosis. Frontiers in Immunology, 8(January), 1-18. (Article publié).
  • Gharagozloo M, Mahmoud S, Mahvelati TM , Amrani A, and Denis Gris. (2018). Nlrp12The dual immunoregulatory function of in T Cell-mediated Immune Response. :Lessons from Experimental Autoimmune Encephalomyelitis. Cells, 7(9), 1-19. (Article publié).
  • Chantal Guindi *, Alexandre Cloutier, Simon Gaudreau *, Echarki Zerif *, Patrick McDonald, Claude Asselin, Gilles Dupuis, Denis Gris And Abdelaziz Amrani. (2018). Role of CREB/C/EBPbeta axis in the Regulation of the Phenotype and IL-10/IL-12 Production in Tolerogenic Bone Marrow-Derived Dendritic cells. Cells, ??(??), 1 - 30. (Article soumis).
  • Guindi C* , Cloutier A, Gaudreau S* , Zerif E *, McDonald PP, Tatsiy O, Asselin C, Dupuis G, Dris D' AND Amrani A. (2018). Role of the p38MAPK/C/EBP? Pathway in the regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic cells. Cells, 7(12), 1-21. (Article accepté).
  • Zerif Echarki *, Aida Maalem *, Simon Gaudreau *, Chantal Guindi *, Muhammad Ramzan*, Steeve Véroneau, Denis Gris, Jana Stankova, Marek Rola-Pleszczynski, Walid Mourad, Gilles Dupuis and Abdelaziz Amrani. (2017). Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression. Journal of Autoimmunity, 76(6), 63-74. (Article accepté).
  • Chabot, Sylvie; Alvarez, Fernando; Amrani, Abdelaziz and Idriss, Djilali-Saiah. (2016). Novel model of double transgenic mouse results in autoimmune diabetes in males. Autoimmunity, 49(6), 397--404. (Article accepté).
  • Gharagozloo M, Mahvelati TM, Imbeault E, Gris P, Zerif E *, Bobbala D, Ilangumaran S, Amrani A, Gris D. (2015). The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis. J. Nuroinflammation, 12, 198-210. (Article publié).
  • Papon MA , El Khoury NB , Marcouiller F , Julien C , Morin F , Bretteville A , Petry FR , Gaudreau S * , Amrani A , Mathews PM , Hébert SS , Planel E. (2013). Deregulation of protein phosphatase 2A and hyperphosphorylation of ? protein following onset of diabetes in NOD mice. Diabetes, 62(2), 609-17. (Article accepté).
  • Bourgeois-Daigneault MC, Pezeshki AM, Galbas T, Houde M, Baril M, Früh K, Amrani A, Ishido S, Lamarre D, Thibodeau J. (2013). Tollip-induced down-regulation of MARCH1. Results Immunol., 3, 17-25. (Article accepté).

Articles de conférence

  • Echarki Zerif, Aida Selma Maalem, Simon Gaudreau, Chantal Guindi and Abdelaziz Amrani. (2016). Constitutively active Stat5b signalling in dendritic cells confers diabetes protection and halts diabetes progression in NOD mice. FOCIS 2016. (Article accepté).
  • Gaudreau S and Amrani A. (2015). CD4+CD25-PD-1+ Tlymphocytes contribution to diabetes resistance induced by GM-CSF. The 13th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2013), June 27-30, in Boston, Massachusetts. (Article accepté).
  • Muhammad Ramzan, Chantal Guindi, Alexandre Cloutier, Simon Gaudreau and Abdelaziz Amrani. (2015). Dendritic Cells Use PI3K to Control Treg/th17 Balance in Type 1 Diabetes. American diabetes Association 2015, 75th scientific sessions Boston, USA. (Article accepté).
  • Amrani A and Gaudreau S. (2013). CD4+CD25-PD-1+ T lymphocytes contribution to diabetes resistance induced by GM-CSF. The 13th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2013), June 27-30,. (Article accepté).
  • Gaudreau S, Dupuis G and Amrani A. (2013). CD4+CD25-PD-1+ T lymphocytes contribution to diabetes resistance induced by GM-CSF. Federation of Clinical Immunology Society. (Article accepté).
  • Echarki Zerif, Aida Selma Maalem, Simon Gaudreau, Chantal Guindi, Jana Stankova and Abdelaziz Amrani. (2013). Constitutively ActiveSTAT5b Signaling in Dendritic Cells Confers Diabetes Protection and HaltsDiabetes Progression in NOD Mice. The 16th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2013), June 22-25, in Boston, Massachusetts. (Article accepté).

Autres contributions

Présentations

  • (2018). Induction of Immune tolerance in autoimmune diabetes. 3rd World Congress and Expo on Immunology" (Immunology Congress-2018). Pays-Bas.
  • Serif E*, Maalem A*, Gaudreau S*, Stankova J and Amrani A. (2016). Constitutively Active STAT5b Signaling in Dendritic Cells Confers Diabetes Protection and Halts Diabetes Progression in NOD Mice. Federation of Clinical Immunology Societies (FOCIS) 2016. Boston, États-Unis.
  • Guindi C*, Cloutier, Gaudreau S*, Asselin C, and A Amrani. (2015). Dendritic Cells Use PI3K to control Treg/Th17 balance in type 1 diabetes. American Diabetes Association, 75 th scientific sessions. Boston, États-Unis.
  • Maalem A*, Guindi C*, Dupuis G and A. Amrani. (2014). Overcoming defective STAT5B signalling in dendritic cells of NOD confers diabetes protection. Canadian Society for Immunology 2014. Quebec city, Canada.
  • Gaudreau S*, Amrani A. (2013). CD4+CD25-PD-1+ T lymphocytes contribution to diabetes resistance induced by GM-CSF. Federation of Clinical Immunology Societies (FOCIS) 2013. Boston, États-Unis.