Massé, Éric

Professeur, Faculté de médecine et des sciences de la santé
FMSS Dép. de biochimie et de génomique fonction.

Coordonnées

Courriel


819-821-8000, poste 75475


Site Web

Diplômes

(2003) Postdoctorat (Microbiologie). National Institutes of Health.

(2000) Doctorat (Microbiologie). Université de Montréal.

(1996) Maîtrise avec mémoire (Biologie Moléculaire). Université de Montréal.

(1994) Baccalauréat (Microbiologie). Université de Montréal.

Présentation

Sujets de recherche

Bactéries, Métabolisme, Infections bactériennes.

Disciplines de recherche

Biologie moléculaire, Microbiologie.

Mots-clés

Gene Expression, Genetic Modeling, Microbiome, mRNA Translation, RNA-Based Regulation, RNA Chaperone, RNomics, small RNA, Sponge RNAs, Virulence.

Intérêts de recherche

Microbiome

Recherche clinique

Oui

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2015) Bourse de Chercheurs-Boursiers, Senior (FRSQ Senior Research Scholar). Fonds de recherche du Québec - Santé (FRQS). (Prix / Récompense).
  • (2012) Bourse de Chercheurs-Boursiers, Junior II (FRSQ Junior II Research Scholar). Fonds de recherche du Québec - Santé (FRQS). (Prix / Récompense).
  • (2010) CIHR New Investigator Scholar. Instituts de recherche en santé du Canada. (Prix / Récompense).
  • (2007) Bourse de Chercheurs-Boursiers, Junior I (Junior Research Scholar). Fonds de recherche du Québec - Santé (FRQS). (Prix / Récompense).
  • Jean-de-Margerie Award for best paper of the year. Université de Sherbrooke. (Prix / Récompense).
  • Research and Creativity Award ($5,000) Prix de la Recherche et de la Création ($5000). Université de Sherbrooke. (Prix / Récompense).
  • Robert Haynes Young Scientist Award of the Canadian Society for Molecular Biosciences (CSMB). Canadian Society For Molecular Biosciences. (Prix / Récompense).

Financement

Subvention. (Obtenu). Chercheur principal. PHYSIOLOGY AND BIOCHEMISTRY OF SMALL REGULATORY RNAS. Instituts de Recherche en Santé du Canada (IRSC). Project grant. 738225 $ (2018-2023).

Subvention. (Obtenu). Co-chercheur. MOLECULAR DETERMINANTS OF REGULATORY HIERARCHY FOR BACTERIAL SMALL RNAS. National Institutes of Health (NIH) (USA). Prokaryotic Cell and Molecular Biology (NIGMS). 1839583 $ (2017-2022).

Subvention. (Obtenu). Chercheur principal. EMERGING REGULATORY ROLES FOR tRNA FRAGMENTS. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Discovery Grant. 320000 $ (2017-2022).

Subvention. (En cours d’évaluation). Demandeur principal. INTEGRATED PLATFORM TO MAP RNA-PROTEIN AND RNA-RNA INTERACTIONS AT THE TRANSCRIPTOME-WIDE LEVEL. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). RTI. 150000 $ (2018).

Subvention. (Terminé). Co-demandeur. INVESTIGATING THE RELATIONSHIP BETWEEN MICROBIOME SIGNATURE AND INSUFFICIENT WEIGHT GAIN IN INFANTS - Association entre le statut pondéral de l’enfant de 5 ans et son microbiote intestinal: Rôle des facteurs aggravants de la période périnatale.. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Team grant from CRCHUS. 75000 $ (2016-2018).

Subvention. (Terminé). Chercheur principal. DISSEMINATION GRANT FROM THE CIHR FOR THE ANNUAL RIBOCLUB SYMPOSIUM. Instituts de Recherche en Santé du Canada (IRSC). Planning and dissemination grant. 10000 $ (2017).

Publications

Articles de revue

  • Thierry Chénard Mandy Malick Jean Dubé Eric Massé. (2020). The influence of blood on the human gut microbiome. BMC Microbiology, (Article sous presse).
  • Grüll MP Massé E. (2019). Mimicry, deception and competition: The life of competing endogenous RNAs. Wiley Interdiscip Rev RNA, 10(3), e1525. (Article publié).
  • Chakravarty S Massé E. (2019). RNA-Dependent Regulation of Virulence in Pathogenic Bacteria. Front Cell Infect Microbiol., 2019 Oct 9;9:337, DOI. (Article publié).
  • Lalaouna D Eyraud A Devinck A Prévost K Massé E. (2019). RNAGcvB small uses two distinct seed regions to regulate an extensive targetome. Mol Microbiol., 111, 473-486. (Article publié).
  • Silva IJ Barahona S Eyraud A Lalaouna D Figueroa-Bossi N Massé E Arraiano CM. (2019). rhoSraL sRNA interaction regulates the terminator by preventing premature transcription termination of mRNA. Proc Natl Acad Sci U S A., 116(8), 3042-3051. (Article publié).
  • Carrier MC Lalaouna D Massé E. (2018). Broadening the Definition of Bacterial Small RNAs: Characteristics and Mechanisms of Action. Annu Rev Microbiol, 72, 141-161. (Article publié).
  • Lalaouna D Prévost K Laliberté G Houé V Massé E. (2018). Contrasting silencing mechanisms of the same target mRNA by two regulatory RNAs in Escherichia coli. Nucl Acids Res, doi: 10.1093/nar/gkx, 1-13. (Article publié).
  • Carrier MC Laliberté G Massé E. (2018). RNAIdentification of New Bacterial Small Targets Using MS2 Affinity Purification Coupled to Sequencing. Methods Mol Biol, 1737, 77-88. (Article publié).
  • Carrier MC Morin C Massé E. (2018). RNAOn the Prowl: An In Vivo Method to Identify Partners of a sRNA. Methods Enzymol., 612, 251-268. (Article publié).
  • *Lalaouna D, Massé E. (2017). Cut in translation: ribosome-dependent mRNA decay. EMBO Journal, 36, 1120-1122. (Article publié).
  • *Lalaouna D, *Prévost K, *Eyraud A, Massé E. (2017). Identification of unknown RNA partners using MAPS. Methods, 15, 28-34. (Article publié).
  • *Carrier MC *Bourassa JS Massé E. (2017). RNACellular Homeostasis: A Small at the Crossroads of Iron and Photosynthesis. Current Biology, 27, 380-383. (Article publié).
  • Bastet L, Chauvier A, Singh N, Lussier A, Lamontagne AM, *Prévost K, Massé E, Wade JT, Lafontaine DA. (2017). Translational control and Rho-dependent transcription termination are intimately linked in riboswitch regulation. Nucleic Acids Research, 45, 7474-7486. (Article publié).
  • *Carrier MC, *Lalaouna D, Massé E. (2016). A game of tag: MAPS catches up on RNA interactomes. RNA Biology, 13, 473-476. DOI. (Article publié).
  • *Lalaouna D, Massé E. (2016). The spectrum of activity of the small RNA DsrA: not so narrow after all. Current genetics, 62, 261. DOI. (Article publié).
  • *Lalaouna D, *Carrier MC, *Semsey S, *Brouard JS, Wang J, Wade JT, Massé E. (2015). A 3’ external transcribed spacer in a tRNA transcript acts as a sponge for small RNAs to prevent transcriptional noise. Molecular Cell, 58, 393-405. (Article publié).
  • *Lalaouna D, *Carrier MC, Masse E. (2015). Every little piece counts: the many faces of tRNA transcripts. Transcription, 6, 74-77. DOI. (Article publié).
  • Wang J, Rennie W, Ding Y, Massé E, Wade JT. (2015). Identification of Bacterial sRNA Regulatory Targets using Ribosome Profiling. Nucleic Acids Research, 43, 10308-10320. (Article publié).
  • *Lalaouna D, Massé E. (2015). Identification ofsRNA interacting with a transcript of interest using MS2-affinity purificationcoupled with RNA sequencing (MAPS) technology. Genomics Data, 5, 136. DOI. (Article publié).
  • *Lalaouna D, *Carrier MC, Masse E. (2015). The shock absorber: Preventing sRNA transcriptional noise. Cell Cycle, 14, 2539-3540. (Article publié).
  • *Lalaouna D, *Morissette A, *Carrier MC, Massé E. (2015). hnsDsrA regulatory RNA represses both and mRNAs through distinct mechanisms in. Molecular Microbiology, 98, 357-369. (Article publié).
  • *Lalaouna D, *Eyraud A, Chabelskaya S, Felden B, Massé E,. (2014). Regulatory RNAs Involved in Bacterial Antibiotic Resistance. PLoS Pathogens, 10(8), e1004299. (Article publié).
  • *Benjamin JA, Massé E. (2014). The iron-sensing aconitase B binds its own mRNA to prevent sRNA-induced mRNA cleavage. Nucleic Acids Res, 42(15), 10023. (Article publié).
  • Porcheron G, Habib R, Houle S, Caza M, Lépine F, Daigle F, Massé E, Dozois CM,. (2014). The small RNA RyhB contributes to siderophore production and virulence of uropathogenic Escherichia coli. Infection and Immunity, 82(12), 5056. (Article publié).
  • *Salvail H , *Caron MP , *Bélanger J , Massé E. (2013). Antagonistic functions between the RNA chaperone Hfq and an sRNA regulate sensitivity to the antibiotic colicin. The EMBO journal, 32(20), 2764-2778. (Article publié).
  • *Desnoyers G , *Bouchard MP , Massé E. (2013). New insights into small RNA-dependent translational regulation in prokaryotes. Trends in genetics : TIG, 29(2), 92-98. (Article publié).
  • *Lalaouna D , *Simoneau-Roy M , Lafontaine D , Massé E. (2013). Regulatory RNAs and target mRNA decay in prokaryotes. Biochimica et biophysica acta, 1829(6-7), 742-747. (Article publié).
  • *Desnoyers G , Massé E. (2012). Activity of small RNAs on the stability of targeted mRNAs in vivo. Methods in molecular biology (Clifton, N.J.), 905, 245-255. (Article publié).
  • *Caron MP , *Bastet L , Lussier A , *Simoneau-Roy M , Massé E , Lafontaine DA. (2012). Dual-acting riboswitch control of translation initiation and mRNA decay. Proceedings of the National Academy of Sciences of the United States of America, 109(50), E3444-3453. (Article publié).
  • *Desnoyers G , Massé E. (2012). Noncanonical repression of translation initiation through small RNA recruitment of the RNA chaperone Hfq. Genes & development, 26(7), 726-739. (Article publié).
  • *Salvail H , Massé E. (2012). Regulating iron storage and metabolism with RNA: an overview of posttranscriptional controls of intracellular iron homeostasis. Wiley interdisciplinary reviews. RNA, 3(1), 26-36. (Article publié).
  • Lemay JF, *Desnoyers G, Blouin S, Heppell B, Bastet L, St-Pierre P, Massé E, Lafontaine DA. (2011). Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms. PLoS genetics, 7(1), e1001278. (Article publié).
  • Bastet L , Dubé A , Massé E , Lafontaine DA. (2011). New insights into riboswitch regulation mechanisms. Molecular microbiology, 80(5), 1148-1154. (Article publié).
  • *Benjamin JA , *Prévost K , Massé E. (2011). Remote control of mRNA cleavage by a small RNA. Cell cycle (Georgetown, Tex.), 10(11), 1106-1107. (Article publié).
  • *Prévost K, *Desnoyers G, *Jacques JF, *Lavoie F, Massé E. (2011). Small RNA-induced mRNA degradation achieved through both translation block and activated cleavage. Genes & Development, 25, 385-396. (Article publié).
  • *Benjamin JA , *Desnoyers G , *Morissette A , *Salvail H , Massé E. (2010). Dealing with oxidative stress and iron starvation in microorganisms: an overview. Canadian journal of physiology and pharmacology, 88(3), 264-272. (Article publié).
  • *Caron MP, Lafontaine DA, Massé E. (2010). Small RNA-mediated regulation at the level of transcript stability. RNA biology, 7(2), 140-144. (Article publié).

Autres contributions

Cours enseignés

  • BCH720 Structure and Mecanism of Biological Molecules for graduate students - Structure et Mécanisme de Molécules Biologiques. (2007-01-12). Université de Sherbrooke. Canada. Niveau : Deuxième cycle. (3CR).
  • BCH718 Molecular Biology of RNA for graduate students. BCH718. (2005-09-07). Université de Sherbrooke. Canada. Niveau : Deuxième cycle. (3CR).
  • BIM500 Molecular biology of the gene. (2005-09-01). Université de Sherbrooke. Canada. Niveau : Premier cycle. (3CR).
  • GNT305 Fundamental and applied genetics - Génétique fondamentale et appliquée GNT305. GNT305. (2004-09-03). Université de Sherbrooke. Canada. Niveau : Premier cycle. (2CR).

Gestion d'évènements

  • Co-Organiser. (2004-2020). Annual Riboclub Conference. (Conférence).
  • Co-organizer. (2004-2020). Monthly meeting of the RiboClub. (Séminaire).
  • Executive committee member. (2015-2020). Cancer Axis at the CHUS Research Center (CRCHUS). (Association).
  • Executive committee member. (2015-2020). Cancer Theme at the Université de Sherbrooke. (Association).
  • Team leader. (2015-2020). Microbiome platform service. (Association).

Activités de collaboration internationale

  • Co-applicant. (2014-2025). États-Unis.
  • Collaborator. (2006-2025). Danemark.
  • Co-applicant. (2004-2025). États-Unis.
  • Collaborator. (2015-2020). Inde.
  • Collaborator. (2014-2020). Portugal.
  • Collaborator. (2012-2020). États-Unis.
  • Principal Applicant. (2014-2017). France.
  • Collaborator. (2005-2012). États-Unis.

Présentations

  • (2019). Capture of small RNA targets. Invited Lecture at Dartmouth University. Hanover, États-Unis.
  • (2019). Fonction of the RNA chaperone Hfq for sRNA targetome. EMBO | EMBL Symposium THE NON-CODING GENOME. Heidelberg, Allemagne.
  • (2018). Hfq and its new mechanisms. 5th Meeting of Regulating with RNA in Bacteria & Archaea. Sevilla, Espagne.
  • (2018). The RNA chaperone Hfq and its targetome. Non-coding RNA biology conference. Buenos Aires, Argentine.
  • (2018). The RNA chaperone Hfq binds target mRNA to induce degradation. FASEB conference on post-transcriptional control of gene expression. Arizona. July 2018. Scottsdale, États-Unis.
  • (2017). New roles for the RNA chaperone Hfq in the regulation of small RNAs. Invited Talk at CNRS Marseille. Marseille CNRS, France.
  • (2017). New roles for the RNA chaperone Hfq in the regulation of small RNAs. Invited Talk at CNRS (Paris) and external reviewer for a thesis defense. Paris CNRS, France.
  • (2017). The role of RNA chaperone for the function of small regulatory RNAs. Invited talk at the Lady Davis Institute, McGill University, Montreal. Canada.
  • (2016). Capturing the RNA targetome of sRNAs. Invited talk at Harvard University, Boston. Boston, États-Unis.
  • (2016). Capturing the RNA targetome of sRNAs. Invited talk at McGill University, Montreal. Montreal, Canada.
  • (2016). Hfq binds mRNAs to promote sRNA-mediated cleavage. 2016 Riboclub Meeting. Sherbrooke, Canada.
  • (2015). Capturing the RNA targetome of sRNAs. Invited talk at the NIH, Bethesda, MD. Bethesda, États-Unis.
  • (2015). New players in the sRNA field. 6th FEMS (Federation of European Microbiology Societies) Maastricht (NDL) June 7-11 / 2015. Maastricht, Pays-Bas.
  • (2015). Regulating sRNAs with sponge RNAs. Invited talk University of Alberta (Biol Dept). Edmonton, Canada.
  • (2015). Small RNAs and antibiotics resistance. ICAAC. Regulatory RNAs in Antibiotics Resistance Mechanisms in a Symposium entitled RNA in Infection Pathogenesis. San Diego, États-Unis.
  • (2014). Mapping the targetome of an iron-responsive small RNA. Invited talk at Université de Strasbourg. Strasbourg, France.
  • (2014). Mapping the targetome of an iron-responsive small RNA. Université de Rennes. Rennes, France.
  • (2014). The dark matter of the genome: mapping the targetome of an iron-responsive small RNA. International union of microbiological societies, Montreal. Montreal, Canada.
  • (2014). The dark matter of the genome: mapping the targetome of an iron-responsive small RNA. 15th Annual Riboclub Conference. Orford, Canada.
  • (2013). New insights in regulation of translation with RNA in Bacteria. Invited speaker at the Copenhagen University, Denmark. Copenhagen, Danemark.
  • (2013). New mechanism of mRNA Regulation with small RNA in Bacteria. Invited Speaker at Yale University, CT, USA. New Haven, États-Unis.
  • (2013). Regulating mRNA translation and decay with small RNAs in E. coli. ASM General Meeting, Denver. Denver, États-Unis.
  • (2013). Regulating mRNA translation and decay with small RNAs in E. coli. ASM Conference: Regulating with RNA in Bacteria. Wurzburg, Allemagne.
  • (2013). Regulating translation with RNA in Bacteria. Invited speaker at the University of Toronto, Ontario Canada. Toronto, Canada.
  • (2013). The Regulation of translation with RNA chaperone in Bacteria. Invited Speaker at Utrecht University, Netherlands. Utrecht, Pays-Bas.
  • (2013). Translation modulation with small RNA in Bacteria. Invited speaker at Laval University, Quebec, Canada. Quebec, Canada.
  • (2012). Regulating mRNA translation and decay with sRNAs during iron, carbon, and membrane stress. 2012 Gordon Research Conference: Microbial Stress Response, Holyoke. South Hadley, États-Unis.
  • (2012). Regulating mRNA translation and decay with sRNAs during iron, carbon, and membrane stress. Invited speaker at the Wadsworth Center, New York State Department of Health. Albany, États-Unis.
  • (2012). Regulating mRNA translation and decay with sRNAs during iron, carbon, and membrane stress. 2012 FASEB Summer Research Conference entitled “Post-transcriptional Control of Gene Expression: Mechanisms of mRNA Decay”. Steamboat Springs, États-Unis.
  • (2011). Post-transcriptional Control of Gene Expression by small RNAs. Special Summer Conference in RNA. The Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal. Montreal, Canada.
  • (2011). The role of a sRNA in the production of siderophore synthesis. Conference on Small Systems Biology, Denmark. Dragor, Danemark.
  • (2010). Adaptation to iron starvation by a sRNA regulating intracellular iron and siderophore synthesis. Invited speaker by the Department of Microbiology, University of Illinois at Urbana-Champaign. Urbana-Champaign, États-Unis.
  • (2009). A small RNA involved in siderophore production. Canadian Society for Microbiology Concordia University. Montreal, Canada.
  • (2009). New mechanisms of gene regulation by small regulatory RNAs. Invited Talk at the Center for Models of Life, Niels Bohr Institute. Copenhagen, Danemark.
  • (2009). Small RNA involved in polycistronic mRNA regulation and siderophore production. Invited talk at Institut Armand-Frappier, Laval. Laval, Canada.
  • (2009). Small RNA involved in polycistronic mRNA regulation and siderophore production. 6th Canadian Oxidative Stress Consortium, Winnipeg. Winnipeg, Canada.
  • (2008). New mechanisms of small regulatory RNAs. Invited talk by the Departement of Biochemistry and Chemistry, Concordia University. Montreal, Canada.
  • (2008). Polar regulation of an operon by a small RNA. Invited talk by the Department of Microbiology, Université de Montréal. Montreal, Canada.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.