Présentation

Sujets de recherche

Hypertension artérielle, Maladies cardiovasculaires, Maladies du système immunitaire, Médiateurs immunologiques: cytokines et chimiokines, Signalisation cellulaire.

Disciplines de recherche

Biologie cellulaire, Pharmacologie.

Mots-clés

cancer, endocytosis, g protein-coupled recepto, inflammation, protein interaction, receptor, recycling, signaling, trafficking.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

• (2015) André Lussier Research Chair. Université de Sherbrooke. (Prix / Récompense).
• (2011) Editor's choice, Journal of Cell Science. (Distinction).
• (2011) Selection by Faculty of 1000. (Citation).
• (2007) Pierre-and-Danielle Bourgaux Award. (Distinction).
• Editorial about our work and cover page. (Distinction).

Publications

Articles de revue

• * Beaudry H, Mercier-Blais AA, Delaygue C, Lavoie C, Parent JL, Neugebauer W, Gendron L. (2015). * Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5. British Journal of Pharmacology, 172(10), 2573-87. (Article publié).
• Binda C and Parent JL. (2015). Characterization of the interaction between the prostaglandin D2 DP1 receptor and the intracellular L-prostaglandin D synthase. Methods Mol Biol, 1234, 53-67. (Article publié).
• Lachance V, Angers S, Parent JL. (2014). New insights in the regulation of Rab GTPases by G protein-coupled receptors. Small GTPases, 5:e29039, (Article publié).
• Li Yue, Sonia Haroun, Jean-Luc Parent, Artur J. de Brum-Fernandes. (2014). Prostaglandin D2 Induces Apoptosis of Human Osteoclasts through ERK1/2 and Akt Signaling Pathways. Bone, 60, 112-121. (Article publié).
• Chantal Binda, Samuel Génier, Jason C. Young and Jean-Luc Parent. (2014). Functional cooperativity from an interaction between a GPCR and the intracellular synthase for its agonist. Journal of Cell Biology, 204(3), 377-393. (Article publié).
• Lachance V , Degrandmaison J , Marois S , Robitaille M , Génier S , Nadeau S , Angers S , Parent JL. (2013). Ubiquitination and activation of a Rab GTPase promoted by a β2-Adrenergic Receptor/HACE1 complex. Journal of cell science, (Article publié).
• Roy SJ , Glazkova I , Fréchette L , Iorio-Morin C , Binda C , Pétrin D , Trieu P , Robitaille M , Angers S , Hébert TE , Parent JL. (2013). Novel, Gel-free Proteomics Approach Identifies RNF5 and JAMP as Modulators of GPCR Stability. Molecular endocrinology (Baltimore, Md.), 27(8), (Article publié).
• Iorio-Morin C , Germain P , Parent JL. (2013). Better management of Western blotting results using professional photo management software. Electrophoresis, 34(8), (Article publié).
• Labrecque P , Roy SJ , Fréchette L , Iorio-Morin C , Gallant MA , Parent JL. (2013). Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. PloS one, 8(6), (Article publié).
• Iorio-Morin C , Germain P , Roy S , Génier S , Labrecque P , Parent JL. (2012). Thromboxane A(2) modulates cisplatin-induced apoptosis through a Siva1-dependent mechanism. Cell death and differentiation, 19(8), (Article publié).
• Roy S , Roy SJ , Pinard S , Agulleiro MJ , Cerdá-Reverter JM , Parent JL , Gallo-Payet N. (2012). The C-terminal domains of melanocortin-2 receptor (MC2R) accessory proteins (MRAP1) influence their localization and ACTH-induced cAMP production. General and comparative endocrinology, 176(2), (Article publié).
• Roy S , Roy SJ , Pinard S , Taillefer LD , Rached M , Parent JL , Gallo-Payet N. (2011). Mechanisms of melanocortin-2 receptor (MC2R) internalization and recycling in human embryonic kidney (hek) cells: identification of Key Ser/Thr (S/T) amino acids. Molecular endocrinology (Baltimore, Md.), 25(11), (Article publié).
• Lachance V , Cartier A , Génier S , Munger S , Germain P , Labrecque P , Parent JL. (2011). Regulation of β2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor. The Journal of biological chemistry, 286(47), (Article publié).
• Cartier A , Parent A , Labrecque P , Laroche G , Parent JL. (2011). WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex. Journal of cell science, 124(Pt 19), (Article publié).
• Li S , Esterberg R , Lachance V , Ren D , Radde-Gallwitz K , Chi F , Parent JL , Fritz A , Chen P. (2011). Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity. Proceedings of the National Academy of Sciences of the United States of America, 108(6), (Article publié).
• Mathurin K , Gallant MA , Germain P , Allard-Chamard H , Brisson J , Iorio-Morin C , de Brum Fernandes A , Caron MG , Laporte SA , Parent JL. (2011). An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production. The Journal of biological chemistry, 286(4), (Article publié).
• Parent A , Roy SJ , Iorio-Morin C , Lépine MC , Labrecque P , Gallant MA , Slipetz D , Parent JL. (2010). ANKRD13C acts as a molecular chaperone for G protein-coupled receptors. The Journal of biological chemistry, 285(52), (Article publié).

Autres contributions

Activités de collaboration internationale

• collaborator. (2011-2012).
• collaborator. (2010-2011).
• Principal Investigator. (2010-2011).
• collaborator. (2015).

Présentations

• (2013). Regulation of Rab GTPases by GPCRs in receptor export. GPCR Retreat. Cleveland.
• (2013). New interactions in GPCR maturation and export. Université de Montpellier. Montpellier.
• (2012). Regulation of GPCR trafficking. Medical University of South Carolina. Charleston.
• (2010). Regulation of TPbeta signalling and trafficking. Southern Ilinois University. Carbondale.