Jacques, Danielle

Professeure, Faculté de médecine et des sciences de la santé
FMSS Dép. d'immunologie et de biologie cellulaire

Coordonnées

Courriel


819-821-8000, poste 75419

Diplômes

(1998) Post-doctorate (Postdoctoral Fellow). Douglas Hospital Research Centre.

(1994) Doctorate (Doctor of Philosophy). Université de Sherbrooke.

(1992) Doctorate (Ph.D. training). Université de Montréal.

(1989) Master's Thesis (Master of Science - Masters). Université de Sherbrooke.

(1987) Bachelor's (Bachelor of Science). Université de Sherbrooke.

Expérience académique

(2016) Associate professor. Alfaisal University, Riyadh, Saudi Arabia.

(2016) Professor responsible for the Integration of Basic Sciences and conception of APP (Problem solving, 8-10 students) and APE (Team problem solving, 40 students) in the New Medical Curriculum Program of the Faculty of Medecine and Health Sciences. Université de Sherbrooke.

(2016) Director- BioMed I- Medical Program of the Faculty of Medecine and Health Sciences. Université de Sherbrooke.

(2007-2013) Director- Nutrition and Successful Aging Group that is part of the Québec Network for Research on Aging. Fonds de recherche du Québec - Santé (FRQS).

Présentation

Sujets de recherche

Cardiomyopathy, Cardiovascular Diseases, Cellular Aging, Electrophysiology, Neuropharmacology.

Disciplines de recherche

Cardiology, Pharmacology, Neurosciences.

Mots-clés

Binding assays, Cardiovascular, Electrophysiology, Endothelium, Immunohistochemistry, Intracellular calcium, Peptides, Pharmacology, Physiopathology, Receptors.

Intérêts de recherche

Endocardial endothelium in hypertrophy and heart failure

Centre de recherche

Centre de recherche sur le vieillissement du CIUSSS de l’Estrie – CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2014) Editor-in-chief /Revue Médecine Sciences Amérique. Revue Médecine Sciences Amérique. (Distinction).
  • (2008) Chercheur boursier/New Investigator Research Award. Heart and Stroke Foundation of Canada. (Prize / Award).
  • (2005) Prize Alfred B. Grossman. Heart and Stroke Foundation of Canada. (Prize / Award).
  • (2002) Chercheur boursier Junior 1. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • (1998) Postdoctoral Fellowship. Fonds de la recherche en santé du Canada. (Prize / Award).
  • (1994) Ph.D. Research Fellowship. Heart and Stroke Foundation of Canada. (Prize / Award).
  • (1993) Ph.D. Research Fellowship. FCAR. (Prize / Award).
  • 6 articles among the 10 most cited in the field of AngII and ET-1. BioMedLib. (Distinction).
  • Associate editor/ Canadian Journal of Physiology and Pharmacology. Canadian Journal of Physiology and Pharmacology. (Distinction).
  • C.J.P.P. Annual Award 2004. Pharmacological Society of Canada. (Distinction).
  • Chair of the Highlighted Symposium for "Stressed Skeletal Muscle". International Conference for Adaptations and Nutrition in Sports (ICANS 2020) to be held during July 10-12 in Taipei, Taiwan. International Conference for Adaptations and Nutrition in Sports (ICANS).
  • Distinguished Service Award in Cardiovascular Science, Medicine and Surgery. International Academy of Cardiovascular Sciences. (Prize / Award).
  • Editorial. Circulation Research. (Distinction).
  • Fellow of the International Academy of Cardiovascular Sciences. International Academy of Cardiovascular Sciences. (Honor).
  • Member of the Editorial Board/Molecular and Cellular Biochemistry. Molecular and Cellular Biochemistry. (Distinction).
  • Prix -George Fodor Feature Symposium. CIHR Young Investigator Forum. (Distinction).
  • Secretary of the local organizing committee of the Annual meeting of the International Academy of Cardiovascular Sciences- North American Section to be held in Sherbrooke, September 2016. International Academy of Cardiovascular Sciences- North American Section. (Distinction).

Financement

Grant. (Awarded). Principal Applicant. Modulation of cytosolic and nuclear calcium in endocardial endothelium by Endothelin-1.. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grant Program. 125000 $ (2017-2022).

Grant. (Awarded). Principal Applicant. Role d'un dialogue entre les récepteurs du neuropeptide Y et de l'endothéline-1 dans le couplage excitation-sécrétion et le remodelage des cellules endothéliales endocardiques.. University of Sherbrooke. Fonds de dépannage. 23166 $ (2019).

Publications

Articles de revue

  • Jacques, D., Provost, C., *Normand, A., *Abou Abdallah, N., Al-Khoury, J., Bkaily, G. (2019). Angiotensin II induces apoptosis of human right and left ventricular endocardial endothelial cells by activating the AT2 receptor. Canadian Journal of Physiology and Pharmacology, 97(6), 581-588. (Published).
  • Jacques D. and Bkaily G. (2019). Endocardial endothelial cell hypertrophy takes place during the development of hereditary cardiomyopathy. Molecular and Cellular Biochemistry, 453(1-2), 157-161. (Published).
  • Chamoun, M., Jacques, D., and Bkaily, G. (2019). Extracellular and intracellular tumor necrosis factor alpha modulates cytosolic and nuclear calcium in human cardiovascular cells. Canadian Journal of Physiology and Pharmacology, 97(9), 820-828. (Published).
  • Bkaily, G., Najibeddine, W., Jacques, D. (2019). Increase of NADPH oxidase 3 in heart failure of hereditary cardiomyopathy. Canadian Journal of Physiology and Pharmacology, 97(9), 902-908. (Published).
  • Bkaily, G. Jazzar, A., Normand, A., Simon, Y., Al-Khoury, J., Jacques, D. (2019). Taurine and cardiac disease: state of the art and perspectives. Canadian Journal of Physiology and Pharmacology, doi: 10.1139/cjpp-2019-0313. [Epub ahead of print], (In Press).
  • Bkaily G., *Simon, Y., *Menkovic, I., Bkaily, C. and Jacques, D. (2018). High salt-induced hypertrophy of human vascular smooth muscle cells associated with a decrease in glycocalyx. Journal of Cellular and Molecular Cardiology, 125, 1-5. (Published).
  • Houde M, Schwertani AG, Touil H, Desbien L, Sarrhini O, Lecomte R, Lepage M, , Gagnon H, Takai S, Pejler G, Jacques D, Gobeil Jr F, Day R, and D'Orleans-Juste P. (2018). Mouse mast cell protease 4 deletion protects heart function and survival after acute myocardial infarction. Frontiers in Pharmacology doi: 10.3389/fphar.2018.00868., 9(art. 868), 1-15. (Published).
  • Hassan, G.S., Jacques, D. D'Orléans-Juste, P., Magder, S., and Bkaily, G. (2018). Physical contact between human vascular endothelial and smooth muscle cells modulates cytosolic and nuclear calcium homeostasis. Canadian Journal of Physiology and Pharmacology, 96(7), 655-661. (Published).
  • Kamal M, Jacques D, and Bkaily G. (2017). Angiotensin II receptors' modulation of calcium homeostasis in human vascular endothelial cells. Canadian Journal of Physiology and Pharmacology, 95(10), 1289-1297. (Published).
  • Jacques D, *Abdel-Karim Abdel-Malak N, *Abou Abdallah N, Al-Khoury J, and Bkaily. (2017). Difference in the response to angiotensin II between left and right ventricular endocardial endothelial cells. Canadian Journal of Physiology Pharmacology, 95(10), 1271-82. (Published).
  • Bkaily G and Jacques D. (2017). Na+-H+ exchanger and proton channel in heart failure associated with Becker and Duchenne muscular dystrophies. Canadian Journal of Physiology and Pharmacology, 95(10), 1213-23. (Published).
  • Jacques D, D'Orleans-Juste P, Magder S, and Bkaily G. (2017). Neuropeptide Y and its receptors in ventricular endocardial endothelial cells. Canadian Journal of Physiology and Pharmacology, 95(10), 1224-29. (Published).
  • Mikhail M, Vachon PH, D'Orleans-Juste P, Jacques D, and Bkaily G. (2017). Role of endothelin-1 and its receptors ETA and ETB in the survival of human vascular endothelial cells. Canadian Journal of Physiology and Pharmacology, 95(10), 1298-1305. (Published).
  • *Dima Abdel-Samad, Ghassan Bkaily, Sheldon Magder and Danielle Jacques. (2016). ETA and ETB receptors contribute to Neuropeptide Y-induced secretion of endothelin-1 in right but not left human ventricular endocardial endothelial cells. Neuropeptides, 55, 145-53. (Published).
  • Ghassan Bkaily, Mirna Chahine, Johny Al-Khoury, *Levon Avedanian, Norbert Beier, Wolfgang Scholz and Danielle Jacques. (2015). Na+-H+ exchanger inhibitor prevents early death in hereditary cardiomyopathy. Canadian Journal of Physiology and Pharmacology, 93(11), 923-34. (Published).
  • *Farah Jules, *Levon Avedanian, Johny Al-Khoury, *Ramatoulaye Keita, *Alexandre Normand, Ghassan Bkaily and Danielle Jacques. (2015). Nuclear membranes ETB receptors mediate ET-1-induced increase of nuclear calcium in human left ventricular endocardial endothelial cells. Journal of Cardiovascular Pharmacology, 66(1), 50-7. (Published).
  • Ghassan Bkaily, *Levon Avedanian, Johny Al-Khoury, *Marc Chamoun, *Rana Semaan, *Cynthia Jubinville-Leblanc, Pedro D'Orléans-Juste and Danielle Jacques. (2015). Nuclear membranes R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. Canadian Journal Physiology and Pharmacology, 93(4), 291-7. (Published).
  • Bkaily, G., Al-Khoury, J., Jacques, D. (2014). Nuclear membranes GPCRs: possible implication in cardiovascular health and disease. Current Vascular Pharmacology, 12(2), 215-22. (Published).
  • Jacques, D. (2013). Entrevue éditoriale avec Monsieur le Ministre de la Santé, Dr Réjean Hébert. Revue Médecine Sciences Amérique, 2(3), 3-9. (Published).
  • *Ahmarani L, *Avedanian L, *Al-Khoury J, *Perreault C, Jacques D, Bkaily G. (2013). Whole-cell and nuclear NADPH oxidases levels and distribution in human endocardial endothelial vascular smooth muscle, and vascular endothelial cells. Canadian Journal of Physiology and Pharmacology, 91(1), 71-9. (Published).
  • *Adbel-Samad D, *Perreault C, *Ahmarani L, *Avedanian L, Bkaily G, Magder S, D'Orléans-Juste P, Jacques D. (2012). Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells. Neuropeptides, 46(6), 373-382. (Published).
  • Jacques, D. (2012). Entrevue Éditoriale: La recherche au Québec vue par le premier scientifique en chef, le Pr Rémi Quirion. Revue Médecine Sciences Amérique, 1(1), 1-5. (Published).
  • Jacques, D. (2012). Entrevue Éditoriale avec le Dr Alain Beaudet, Président des Instituts de Recherche en Santé au Canada. Revue Médecine Sciences Amérique, 1(3), 1-6. (Published).
  • Jacques, D. (2012). Entrevue Éditoriale avec le Dr Gérard Eugène Plante. Revue Médecine Sciences Amérique, 1(4), 27-32. (Published).
  • Bkaily G, *Avedanian L, *Al-Khoury J, *Ahmarani L, *Perreault C, Jacques D. (2012). Receptors and ionic transporters in nuclear membranes: new targets for therapeutical pharmacological interventions. Canadian Journal of Physiology and Pharmacology, 90(8), 953-65. (Published).
  • Bkaily G , *Avedanian L , *Al-Khoury J , *Provost C , Nader M , D'Orléans-Juste P , Jacques D. (2011). Nuclear membrane receptors for ET-1 in cardiovascular function. American Journal of Physiology, 300(2), R251-63. (Published).
  • *Avedanian L , Jacques D , Bkaily G. (2011). Presence of tubular and reticular structures in the nucleus of human vascular smooth muscle cells. Journal of Molecular and Cellular Cardiology, 50(1), 175-86. (Published).
  • *Avedanian L , Riopel J , Bkaily G , Nader M , D'Orleans-Juste P , Jacques D. (2010). ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium. Canadian Journal of Physiology and Pharmacology, 88(8), 817-29. (Published).
  • Der-Boghossian AH , Saad SR , *Perreault C , *Provost C , Jacques D , Kadi LN , Issa NG , Sibai AM , El-Majzoub NW , Bikhazi AB. (2010). Role of insulin on jejunal PepT1 expression and function regulation in diabetic male and female rats. Canadian Journal of Physiology and Pharmacology, 88(7), 753-9. (Published).

Chapitres de livre

  • Ghassan Bkaily, Johny Al-Khoury, *Yanick Simon, Danielle Jacques. (2016). Intracellular free calcium measurement using confocal imaging. Rhian M. Touyz and Ernesto L. Schffrin (Eds) Methods Molecular Biology, Vol. 1527, Rhian M. Touyz and Ernesto L. Schffrin (Eds) : Hypertension 2017 (Rhian M. Touyz & Ernesto L. Schiffrin (Eds), 1527, 177-187). United Kingdom : Springer Nature. (Published).
  • Ghassan Bkaily and Danielle Jacques. (2016). Intracellular sodium overload in hereditary cardiomyopathy. Narosa Publishing Adaptative Biology & Medicine, XI International Society of Adaptative Medicine ( ISAM) World Congress Proceedings (Narosa Publishing, 8, -). Japan : Narosa Publishing. (In Press).
  • Ghassan Bkaily and Danielle Jacques. (2013). Use of confocal microscopy to investigate cell structure and function. P. Michael Conn Techniques in confocal microscopy (P. Michael Conn, 105-122). United Kingdom : Elsevier. (Published).
  • Jacques, D., Sader, S., Perreault, C. and Abdel-Samad, D. (2006). NPY and NPY receptors: presence, distribution and roles in the regulation of the endocardial endothelium and cardiac function. Z. Zukowska and G.Z. Feuerstein EXS- Series on NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics (Z. Zukowska & G. Z. Feuerstein Edt., 77-87). Switzerland : Birkhauser Verlag. (Published).

Articles de conférence

  • *Abou Abdallah, N., Hassan, G., *Simon, Y., Jacques, D., Bkaily, G. (2018). Physical contact between vascular endothelial and smooth muscle cells mediate increase in intracellular calcium. 37th Annual conference of the North American Section of the International Society of Heart Research, Halifax, Nova Scotia, May 29th-June 1st 2018. (Published).
  • *Simon Y, *Abou Abdallah N, Al-Khoury J, Jacques D, Bkaily, G. (2017). Regulation of cytosolic and nuclear ROS and calcium by endothelin-1 in cardiovascular cells. 5th Forum to promote Young Investigator and Centers of Excellence in Cardiovascular Research, Annual meeting of the North American Section of the International Academy of Cardiovascular Sciences (IACS). (Published).
  • Johny Al-Khoury, Danielle Jacques, Ghassan Bkaily. (2016). Angiotensin II receptors modulation of calcium homeostasis in human vascular endothelial cells. 4th Annual meeting of the International Academy of Cardiovascular Sciences, Sherbrooke, Qc, September 22-24th 2016. (Published).
  • *Cynthia Jubinville-Leblanc, *Dima Abdel-Samad, *Alexandre Normand, Ghassan Bkaily, Danielle Jacques. (2016). ETA and ETB receptors contribute to neuropeptide Y-induced secretion of endothelin-1 in right but not left human ventricular endocardial endothelial cells. 4th Annual meeting of the International Academy of Cardiovascular Sciences, Sherbrooke, Qc, September 22-24th 2016. (Published).
  • *Chamoun Marc, *Abdel-Karim Abdel-Malak Nelly, *Provost Chantale, *Simon Yanick, Bkaily Ghassan and Jacques Danielle. (2015). Angiotensin II receptor distribution, internalization and modulation of intracellular calcium: differences between human right and left ventricular endocardial endothelial cells. Annual meeting of the International Academy of Cardiovascular Sciences, North American Section. (Published).
  • *Keita Ramatoulaye, *Jules Farah, Al-Khoury Johny, Bkaily Ghassan, and Jacques Danielle. (2015). Nuclear membranes ETB receptors mediate ET-1-induced increase of nuclear calcium in human endocardial endothelial cells. Annual meeting of the International Academy of Cardiovascular Sciences, North American Section. (Published).
  • Jacques, D. and Bkaily, G. (2014). Role of sodium-hydrogen exchange in vascular failure in hereditary cardiomyopathy. Cardiovascular Research, S126. (Published).
  • *Keita R, *Najibeddine W, *Normand A, D'Orléans-Juste P, Magder S, Jacques D. (2013). Differences in excitation-secretion coupling exist between left and right human endocardial endothelial cells. International Society for Heart Research (ISHR) XXI World Congress. (Published).
  • *Al-Khoury J, Semaan W, *Najibeddine W, D'Orléans-Juste P, Magder S, Jacques D, Bkaily G. (2013). ET-1 and NHE1 in vascular failure in hereditary cardiomyopathy. International Society for Heart Research (ISHR) XXI World Congress. (Published).
  • Bkaily G, Jacques D. (2013). Hereditary cardiomyopathy is also a vascular disease: the sodium-hydrogen exchanger a key common player?. International Academy of Cardiovascular Sciences, Slovakia. (Published).
  • *Najibeddine W, *Jules F, *Normand A, *Keita R, Jacques D. (2013). Nuclear membranes ETB receptors mediate ET-1 induced increase of nuclear calcium in human right and left ventricular endocardial endothelial cells. International Society for Heart Research (ISHR) XXI World Congress. (Published).
  • Al-Khoury J, *Ahmarani L, *Chamoun M, *Najibeddine W, Jacques D, Bkaily G. (2013). Presence of NOX1-5 in human vascular smooth muscle and endothelial cells: regulation of nuclear calcium. International Society for Heart Research (ISHR) XXI World Congress. (Published).
  • Jacques, D., Magder, S., D'Orléans-Juste, P., Bkaily, G. (2012). Human endocardial endothelial cells hypertrophy and release of endothelin-1: Role of Neuropeptide Y and Angiotensin II. 10th International NPY-PYY-PP Meeting. (Published).
  • *Ahmarani L , *Perreault C , Bkaily G , Magder S , D'Orléans-Juste P , Jacques D. (2012). Neuropeptide Y receptors and neuropeptide Y-induced secretion are different in left compared to right ventricular human endocardial cells. 10th International NPY-PYY-PP Meeting. (Published).
  • Bkaily G , Jacques D. (2012). Regulation of nuclear ROS by ET-1 and AngII in human vascular smooth muscle and endothelial cells. 7th Meeting of the Canadian Oxidative Stress Consortium. (Published).
  • *Avedanian L, Jacques D, D'Orléans-Juste P, Bkaily G. (2011). ET-1 modulates tubular and reticular structures in the nucleus. 12th International Conference on Endothelin. (Published).
  • *Al-Khoury J, *Abdel-Samad D, *Provost C, Magder S, D'Orléans-Juste P, Bkaily G, Jacques D. (2011). Modulation of release of endothelin-1 in hypertrophic human endocardial and vascular endothelial cells. 12th International Conference on Endothelin. (Published).
  • Jacques D, Bkaily G. (2011). Neuropeptide Y and Angiotensin II induce human endocardial endothelial cell hypertrophy and release of endothelin-1. International Society for Heart Research Meeting - European Section. (Published).
  • Bkaily G, Jacques D. (2011). Nuclear membrane G-protein coupled receptors and nuclear T-tubules contribute to normal and pathological cell function. Winnipeg Heart International - Institute of Cardiovascular Sciences. (Published).
  • Bkaily G, Jacques D. (2011). Nuclear membranes G-proteins coupled receptors and nuclear T-tubules contribute to vascular smooth muscle cells function. International Society for Heart Research Meeting - European Section. (Published).

Autres contributions

Gestion d'évènements

  • Secretary of the local organizing committee. (2016). Annual meeting of the International Academy of Cardiovascular Sciences, North American Section, September 22-24th 2016. (Conference).
  • Chair. (2012). 10th International NPY-PYY-PP Meeting. (Conference).
  • Member of the Local Organizing Committee. (2012). 10th International NPY-PYY-PP Meeting, Montréal, Qc. (Conference).
  • Organizer. (2011). Symposium in Cardiovascular Physiopathology, ACFAS, Sherbrooke, Qc. (Conference).
  • Chairman. (2011). Symposium on Cardiovascular Pharmacology, ACFAS, Sherbrooke, Qc. (Conference).

Présentations

  • Jacques, D. (2018). Cardiac hypertrophy: endocardial endothelial cells are not simple bystanders. 5th meeting of the International Academy of Cardiovascular Sciences –European Section-Advances ?n card?ovascular research: from basic mechanisms to therapeutic strategies, Congress Center of the Slovak Academy of Sciences, Bratislava, May 23-26. Slovakia.
  • Jacques , D. (2018). Role of taurine in the regulation of excitation-secretion coupling and remodeling of human endocardial endothelial cells. International Conference for Adaptations and Nutrition in Sports (ICANS)”, July 18-20, 2018, Chonburi, Thailand. Thailand.
  • Jacques , D. (2017). Endocardial endothelium in cardiac physiopathology: Neuropeptide Y is a new key player. 5th Annual meeting of the International Academy of Cardiovascular Sciences, Orlando, August 31st- September 2nd 2017. Orlando, United States.
  • Jacques , D. (2017). Endocardial endothelium in cardiac physiopathology : implication of Neuropeptide Y. Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada. Halifax, Canada.
  • Jacques , D. (2017). Neuropeptide Y and ROS generation in human endocardial endothelial cells. VI International Symposium on Oxidative Stress and Cardiovascular Diseases, to be held at the Federal University of Rio Grande do Sul, Porto Alegre, Brazil, on November 17th., 2017. Porto Alegre, Brazil.
  • Jacques, D. (2016). Crosstalk between the NPY and ET-1 systems in human endocardial endothelial cells. 4th Annual meeting of the International Academy of Cardiovascular Sciences, Sherbrooke, Qc, September 22-24th 2016. Sherbrooke, Canada.
  • Jacques, D. (2015). Endocardial endothelium and cardiac hypertrophic factors. Congress Center of the Slovak Academy of Sciences, Smolenice Castle. September 2-5th 2015. Bratislava, Slovakia.
  • Jacques, D. (2015). NPY receptors in the nucleus: What are they doing there?. 7th International Conference on «Recent Avances in Cardiovascular Sciences, March 10-11 2015, Amity University, Uttar Pradesh, India. Uttar Pradesh, New Dehli, India.
  • Jacques, D. (2015). Role of endocardial endothelium in cardiac physiopathology. Indo-Canadian Symposium on Heart Failure: Progress & prospects, March 12-14 2015, Trivandium, India. Trivandium, India.
  • Jacques, D. (2014). Excitation-ET-1 secretion coupling in human endocardial endothelial cells. 2nd Cardiovascular Forum for Promoting Centers of Excellence and Young Investigators. Winnipeg, Canada.
  • Jacques, D. (2014). Role of endocardial endothelium in hypertrophy and heart failure. Cuban Congress of Cardiology. La Havana, Cuba.
  • Bkaily, G. and Jacques, D. (2013). Role of NHE1 in the development of heart failure in hereditary cardiomyopathy. KFSH Cardiac Center, AlFaisal University. Riyadh, Saudi Arabia.
  • Jacques, D. (2013). What are neuropeptide Y and its receptors doing in the nucleus of endocardial endothelial cells?. Faculty of medicine, AlFaisal University. Riyadh, Saudi Arabia.
  • Jacques, D. (2012). Human endocardial endothelial cells hypertrophy and release of endothelin-1: Role of neuropeptide Y and angiotensin II. 10th International NPY-PYY-PP Meeting. Montréal, Canada.
  • Jacques, D. (2011). Neuropeptide Y and Angiotensin II induce human endocardial endothelial cells hypertrophy and release of endothelin-1. International Society for Heart Research Meeting - European Section. Haifa, Israel.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.