Présentation

Sujets de recherche

Auto-Immune Diseases, Cell Signaling and Infectious and Immune Diseases, Immunotherapy.

Disciplines de recherche

Biology and Related Sciences, Immunology.

Mots-clés

animal models of T1D, Autoimmune Diabetes, Autoimmunity, Calcium homeostasis, cellular immunology, IL-15 signaling, Immunology, inflammation, Lymophocyte apoptosis, Lymphocte Homeostasis.

Intérêts de recherche

T cells confer protection against pathogens. Sometimes, they can cause autoimmune diseases. Within T cells, several proteins regulate apoptosis, some induce cell death while others promote cell survival. Research in my lab is focused on how one protein, GIMAP5 functions to prevent cell death in T cells. Other research projects are aimed at validating new immunotherapies for autoimmune diabetes and understanding the role of chronic inflammation in obesity and the related metabolic syndromes.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français, Tamoul/Tamil

Publications

Articles de revue

• Bobbala D, Khandhi R,Chen XL, Mayhue M, Yan Y, Barabé F, Ramanathan S* and Ilangumaran S*. (shared senior authorship). (2915). ScidIL-15 deficiency promotes induction of leukemia in NOD. mice by adoptively transferred CD4+ T cells. Leukemia, (Revision Requested).
• Xi-Lin Chen, Daniel Serrano, Marian Mayhue, Kasper Hoebe, Subburaj Ilangumaran and Sheela Ramanathan. (2015). GIMAP5 deficiency is associated with an increase in the spontaneous activity of AKT in T lymphocytes. PLOS One DOI:10.1371/journal.pone.0139019, (Accepted).
• Yuneivy Cepero-Donates, Volatiana Rakotoarivelo, Marian Mayhue, Averil Ma, Yi-Guang Chen and Sheela Ramanathan. (2015). Homeostasis of IL-15 dependent lymphocyte subsets in the liver. Cytokine, (Submitted).
• Yuneivy Cepero-Donates, Gregory Lacraz, Volatiana Rakotoarivelo, Marian Mayhue, Yi-Guang Chen, Alfredo Menendez, Subburaj Ilangumaran and Sheela Ramanathan. (2015). Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease. Cytokine, (Submitted).
• Galaxia M. Rodriguez, Audrey Champagne, Diwakar Bobbala, Daniel Serrano, Marian Mayhue, Viktor Steimle, Thomas Kufer, Caroline Saucier, Sheela Ramanathan and Subburaj Ilangumaran. (2015). NOD-like receptor family CARD domain containing protein 5(NLRC5) enhances tumor cell. Cancer Research, (Submitted).
• Diwakar Bobbala, Marian Mayhue, Alfredo Menendez, Subburaj Ilangumaran and Sheela Ramanathan. (2015). Trans-presentation of IL-15 by IL-15R alpha is dispensable for the pathogenesis of autoimmune type 1 diabetes. Cellular and Molecular Immunology, (Revision Requested).
• Xi-Lin Chen, Daniel Serrano,Marian Mayhue, Kasper Hoebe and Sheela Ramanathan. (2015). TCR and IL-7 signaling are disrupted in the absence of functional GTPase of the immune associated nucleotide binding protein 5 (GIMAP5). Molecular Immunology, (Revision Requested).
• Diwakar Bobbala, Sheela Ramanathan and Subburaj Ilangumaran. (2015). A novel role for IL-21 in modulating T cell antigen receptor reactivity towards low affinity peptides in CD8+ T lymphocytes. Journal of Autoimmunity, (Submitted).
• Gui, Y, Yegneh, M, Donates Y-C, Tobelaim, W-S, Chababi, W, Ramanathan, S, Yoshimura, A, Saucier, C and Ilangumaran, S. (2015). SOCS1 exerts its tumor suppressor function in hepatocellular carcinoma by promoting ubiquitination and proteasomal degradation of the MET receptor tyrosine kinase. Oncogene doi: 10.1038/onc.2015.20. [Epub ahead of print], (Accepted).
• Mehdi Yeganeh, Yirui Gui, Yuneivy Cepero-Donates, Rajani Kandhi, Diwakar Bobbala, William-Sam Tobelaim, Marian Mayhue, Dante d’Urbano, Sameh Geha, Akihiko Yoshimura, Caroline Saucier, Gerardo Ferbeyre, Sheela Ramanathan, and Subburaj Ilangumaran. (2015). Suppressor of cytokine signaling 1 (SOCS1) restrains the paradoxical oncogenic functions of p21CIP1/WAF1 in hepatocytes. Hepatology, (Revision Requested).
• G Lacraz, Y Cepero-Donates, SM Labbé, ... A Menendez, D Richard, G Ferbeyre, J Fradette, M-F Langlois, S Ilangumaran, M Pleszczynski and S. Ramanathan. (2014). Interleukin-15 promotes obesity-associated metabolic dysregulation by inhibiting adaptive thermogenesis in adipose tissues. Diabetes, (Revision Requested).
• Chen XL , Bobbala D , Cepero Donates Y , Mayhue M , Ilangumaran S , Ramanathan S. (2014). IL-15 trans-presentation regulates homeostasis of CD4(+) T lymphocytes. Cellular & molecular immunology, 11(4), 387-97. (Published).
• Chen XL , Bobbala D , Rodriguez GM , Mayhue M , Chen YG , Ilangumaran S , Ramanathan S. (2013). Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8(+) T cells. Clinical and experimental immunology, 173(2), 184-94. (Published).
• Gui Y, Yeganeh M, Cepero-Donates Y, Ramanathan S, Saucier C, Ilangumaran S. (2013). Regulation of MET Receptor Signaling by SOCS1 and its Implications for Hepatocellular Carcinoma. Curr Pharm Des, 20(17), 2922-33. (Published).
• Maria Rodriguez G , D'Urbano D , Bobbala D , Lin Chen X , Yeganeh M , Ramanathan S , Ilangumaran S. (2013). SOCS1 prevents potentially skin-reactive cytotoxic T lymphocytes from gaining the ability to cause inflammatory lesions. The Journal of investigative dermatology, 133(8), 2013-22. (Published).
• Chen XL , Serrano D , Mayhue M , Wieden HJ , Stankova J , Boulay G , Ilangumaran S , Ramanathan S. (2013). GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation. The Biochemical journal, 449(2), 353-64. (Published).
• Bobbala D , Chen XL , Leblanc C , Mayhue M , Stankova J , Tanaka T , Chen YG , Ilangumaran S , Ramanathan S. (2012). Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia, 55(11), 3010-20. (Published).
• Gui Y , Yeganeh M , Ramanathan S , Leblanc C , Pomerleau V , Ferbeyre G , Saucier C , Ilangumaran S. (2011). SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes. Journal of hepatology, 55(6), 1300-8. (Published).
• Ramanathan S , Dubois S , Chen XL , Leblanc C , Ohashi PS , Ilangumaran S. (2011). Exposure to IL-15 and IL-21 enables autoreactive CD8 T cells to respond to weak antigens and cause disease in a mouse model of autoimmune diabetes. Journal of immunology (Baltimore, Md. : 1950), 186(9), 5131-41. (Published).
• Ilangumaran S , Gagnon J , Leblanc C , Poussier P , Ramanathan S. (2010). Increased generation of CD8 single positive cells in SOCS1-deficient thymus does not proportionately increase their export. Immunology letters, 132(1-2), 12-7. (Published).
• Ramanathan S , Dubois S , Gagnon J , Leblanc C , Mariathasan S , Ferbeyre G , Rottapel R , Ohashi PS , Ilangumaran S. (2010). Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. Journal of immunology (Baltimore, Md. : 1950), 185(1), 357-366. (Published).

Articles de conférence

• Xi-Lin Chen, Daniel Serrano, Marian Mayhue, Kasper Hoebe, Subburaj Ilangumaran and Sheela Ramanathan. (2015). GIMAP5deficiency is associated impaired signaling through TCR and IL-7 receptor. 6th Congress of FIMSA. (Accepted).
• Xi-Lin Chen, Daniel Serrano, Marian Mayhue, Kasper Hoebe and Sheela Ramanathan. (2015). GIMAP5deficiency is associated with an increase in the spontaneous activity of AKT inT lymphocytes. Annual Meeting of the Canadian Immunology Society. (Accepted).
• Yuneivy Cepero-Donates, Marian Mayhue, Averil Ma, Subburaj Ilangumaran and Sheela Ramanathan. (2015). Homeostasisof IL-15 dependent lymphocyte subsets in the liver. Annual meeting of the Canadian Society for Immunology. (Accepted).
• Rakotoarivelo V, Mayhue M, Langlois MF et Ramanathan S. (2015). Regulation de l’inflammation dans les tissus adipeux par les cytokines pro-inflammatoires. cytokines in Inflammation, Aging, Cancer and Obesity. (Accepted).
• Orkhis S, Bobbala D, Menendez A, Ilangumaran S and Ramanathan S. (2015). Rôle de l’IL-15 dans les réponses immunitaires. Cytokines in Inflammation, Aging, Cancer and Obesity. (Accepted).
• Rakotoarivelo V, Cepero-Donates Y, Mayhue M, Langlois MF et Ramanathan, S. (2015). Regulation de l’inflammation dans les tissus adipeux par les cytokines pro-inflammatoires. Société québécoise de lipidologie, de nutrition et de métabolisme. (Accepted).
• Lacraz G, Cepero-Donates Y, Mayhue M, Langlois MF, Rola-Pleszczynski M, Ilangumaran S and Ramanathan S. (2014). Diet-induced IL-15 promotes obesity by inhibiting adaptive thermogenesis in adipose tissues. European association for the study of Diabetes. (Published).
• Serrano D, Ilangumaran S, Lavoie C and Ramanathan S. (2014). GIMAP5 affects calcium homeostasis by regulating the movement of organelles. Dynamic Cell. (Accepted).
• Ilangumaran S, Cepero-Donates Y, Lacraz G, Mayhue M and Ramanathan S. (2014). Interleukin-15 signalling promotes high fat diet-induced inflammation in the liver. European association for the study of Diabetes,. (Published).
• Cepero-Donates Y, Lacraz G, Mayhue M, Ramanathan S and Ilangumaran S. (2014). A Pathogenic Role For IL-15 In Fatty Liver Disease. 27th Annual Spring Meeting of the Canadian Society for Immunology. (Accepted).
• Serrano D and Ramanathan S. (2014). A role for GIMAP5 in regulating the movement of organelles. 27th Annual Spring Meeting of the Canadian Society for Immunology. (Accepted).
• Lacraz G, Cepero-Donates Y, Mayhue M, Langlois MF, Rola-Pleszczynski M, Ilangumaran S and Ramanathan S. (2014). Interleukin-15 in the regulation of obesity and fatty liver disease. Indian association for the study of liver. (Accepted).
• Bobbala D, Ilangumaran S and Ramanathan S. (2014). Role of IL-15 And IL-21 In Activating Autoreactive CD8+ T Cells In A Virus-Induced Autoimmune Type 1 Diabetes Model. 27th Annual Spring Meeting of the Canadian Society for Immunology,. (Accepted).
• Lacraz G, Cepero Donates Y, Labbé SM, Vernier M, Mayhue M, Daigle S, Ferbeyre G, Richard D, Fradette J, Langlois M-F, Ilangumaran S, Rola-Pleszczynski M and Ramanathan S. (2014). Mechanisms contributing to the initiation of inflammation in obesity. Keystone Symposia, Obesity: A multisystems perspective. (Accepted).
• Ramanathan S,Bobbala D, Mayhue M, and Ilangumaran S. (2013). Targeting IL-15 for immunotherapy in autoimmune diabetes. European association for the study of Diabetes. (Published).
• Chen XL, Serrano D and Ramanathan S. (2013). GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T lymphocytes by promoting mitochondrial calcium accumulation. 26rd Annual Spring Meeting of the Canadian Society for Immunology. (Accepted).
• Ramanathan S, Bobbala D, Chen XL, Mayhue M, Leblanc C, Tanaka T, Chen YG and Ilangumaran S. (2012). Inflammatory cytokines in the pathogenesis of autoimmune type 1 diabetes. American Association of Immunologists. (Accepted).
• Ilangumaran S, Leblanc C and Ramanathan S. (2011). SOCS1 Controls the pathogenicity of potentially autoreactive CD8+ T cells by regulating cytokine-driven differentiation. Autoimmunity Congress Asia. (Accepted).
• S Ramanathan and S Ilangumaran. (2011). Inflammatory cytokines in autoimmune type 1 diabetes. 10th World Congress of Inflammation. (Accepted).
• Chen XL and Ramanathan. (2011). GIMAP5 regulates mitochondrial Ca2+ Homeostasis. 24rd Annual Spring Meeting of the Canadian Society for Immunology. (Accepted).

Autres contributions

Présentations

• (2015). The role of IL-15 in chronic inflammation in autoimmunity and metabolic syndrome. Invited Seminar. Delhi.
• (2014). GIMAP5 and cell survival - questions and more questions. Babraham Institute. Cambridge.
• (2014). Role of SOCS1 in hepatocellular carcinoma. Invited seminar Global Health Network, Chennai, India. Chennai.
• (2014). Regulation of adaptive thermogenesis by IL-15. Invited seminars Madras Diabetes Research Foundation, Chennai, India. Chennai.
• (2012). An essential role for IL-15 in the pathogenesis of autoimmune diabetes. 5th Federation of Immunological Societies of Asia and Oceania, New Delhi, India.March 14-17, 2012. New Delhi.
• (2012). Essential role of IL-21 in activating autoreactive CD8+ T cells to induce type 1 diabetes in the NOD mouse. 5th Federation of Immunological Societies of Asia and Oceania. New Delhi.
• (2011). Insights into the pro-survival function of GIMAP5 in T lymphocytes. Invited seminar Hopital Purpan, Toulouse, France. Toulouse.
• (2011). Regulation of calcium homeostasis by GIMAP5 in T lymphocytes. Invited seminar Maisonneuve-Rosemont Hospital, University of Montreal, Montreal, Quebec, Canada. Montreal.