Présentation

Sujets de recherche

Infections bactériennes, Infections virales, Maladies infectieuses, Maladies transmises sexuellement.

Disciplines de recherche

Biologie moléculaire, Microbiologie.

Mots-clés

Biocapteurs photoniques, Campylobacter, Chlamydia, Clostridium difficile, diagnostic, herpès, Influenza, Legionella pneumophila, maladies infectieuses, Microbiologie, PCR.

Intérêts de recherche

Utiliser les méthodes moléculaires et les méthodes photoniques pour le diagnostic et les études épidémiologiques de microorganismes d'intérêt clinique. Les projets dans mon laboratoire tournent surtout autour des Chlamydia, Legionella pneumophila, Escherichia coli, le Campylobacter et les virus de la famille herpès et l'influenza.

Recherche clinique

Oui

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Publications

Articles de revue

• Fugère A, Lalonde Séguin D, Mitchell G, Déziel E, Dekimpe V, Cantin AM, Frost E, Malouin F. (2014). Interspecific Small Molecule Interactions between Clinical Isolates of Pseudomonas aeruginosa and Staphylococcus aureus from Adult Cystic Fibrosis Patients. PLoS One, 9(1), (Article publié).
• Lévesque S, Fournier E, Carrier N, Frost E, Arbeit RD, Michaud S. (2013). Campylobacteriosis in Urban versus Rural Areas: A Case-Case Study Integrated with Molecular Typing to Validate Risk Factors and to Attribute Sources of Infection. PLoS One, 8(12), (Article publié).
• Mitchell G , Fugère A , Pépin Gaudreau K , Brouillette E , Frost EH , Cantin AM , Malouin F. (2013). SigB is a dominant regulator of virulence in Staphylococcus aureus small-colony variants. PloS one, 8(5),
• Fulop T , Lacombe G , Cunnane S , Le Page A , Dupuis G , Frost EH , Bourgade-Navarro K , Goldeck D , Larbi A , Pawelec G. (2013). Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 1: clinical and historical background. Discovery medicine, 15(80),
• Fulop T , Lacombe G , Cunnane S , Le Page A , Dupuis G , Frost EH , Bourgade-Navarro K , Goldeck D , Larbi A , Pawelec G. (2013). Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 2: new immune paradigm. Discovery medicine, 15(80),
• Lévesque S , St-Pierre K , Frost E , Arbeit RD , Michaud S. (2012). Use of amplified-fragment length polymorphism to study the ecology of Campylobacter jejuni in environmental water and to predict multilocus sequence typing clonal complexes. Applied and environmental microbiology, 78(7),
• Njouom R , Lavoie M , Foupouapouognigni Y , Frost E , Deslandes S , Mamadou-Yaya F , Mbélesso P , Mbadingai S , Pépin J. (2011). Transmission of hepatitis C virus among spouses in Cameroon and the Central African Republic. Journal of medical virology, 83(12),
• Loo VG , Bourgault AM , Poirier L , Lamothe F , Michaud S , Turgeon N , Toye B , Beaudoin A , Frost EH , Gilca R , Brassard P , Dendukuri N , Béliveau C , Oughton M , Brukner I , Dascal A. (2011). Host and pathogen factors for Clostridium difficile infection and colonization. The New England journal of medicine, 365(18),
• Duplan V, Frost E, Dubowski JJ. (2011). A photoluminescence-based quantum semiconductor biosensor for rapid in situdetection of Escherichia coli. Sensors and Actuators B: Chemical, 160(1), 46-51. (Article publié).
• Lévesque S , St-Pierre K , Frost E , Arbeit RD , Michaud S. (2011). Determination of the optimal culture conditions for detecting thermophilic campylobacters in environmental water. Journal of microbiological methods, 86(1),
• LeGoff J , Grésenguet G , Gody C , Longo Jde D , Khonde N , Weiss HA , Mayaud P , Bélec L ,. (2011). Performance of the BioPlex 2200 multiplexing immunoassay platform for the detection of herpes simplex virus type 2 specific antibodies in African settings. Clinical and vaccine immunology : CVI, 18(7),
• Hassen WH, Duplan V, Frost E, Dubowski JJ. (2011). Quantitation of influenza A virus in the presence of extraneous protein using electrochemical impedance spectroscopy. Electrochimica acta, 56, 8325-8328. (Article publié).
• Lévesque S , Michaud S , Arbeit RD , Frost EH. (2011). High-resolution melting system to perform multilocus sequence typing of Campylobacter jejuni. PloS one, 6(1),
• Pépin J , Deslandes S , Giroux G , Sobéla F , Khonde N , Diakité S , Demeule S , Labbé AC , Carrier N , Frost E. (2011). The complex vaginal flora of West African women with bacterial vaginosis. PloS one, 6(9),
• Gonzales M , Pepin J , Frost EH , Carrier JC , Sirard S , Fortier LC , Valiquette L. (2010). Faecal pharmacokinetics of orally administered vancomycin in patients with suspected Clostridium difficile infection. BMC infectious diseases, 10,
• Pépin J , Labbé AC , Mamadou-Yaya F , Mbélesso P , Mbadingaï S , Deslandes S , Locas MC , Frost E. (2010). Iatrogenic transmission of human T cell lymphotropic virus type 1 and hepatitis C virus through parenteral treatment and chemoprophylaxis of sleeping sickness in colonial Equatorial Africa. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 51(7),
• Arudra P, Nguiffo-Podie Y Frost E, Dubowski JJ. (2010). Decomposition of thimerosal and dynamics of thiosalicylic acid attachment on (001) GaAs surface observed with in-situ photoluminescence. Journal of Physical Chemistry C., 13657-62. (Article publié).
• Mitchell G , Séguin DL , Asselin AE , Déziel E , Cantin AM , Frost EH , Michaud S , Malouin F. (2010). Staphylococcus aureus sigma B-dependent emergence of small-colony variants and biofilm production following exposure to Pseudomonas aeruginosa 4-hydroxy-2-heptylquinoline-N-oxide. BMC microbiology, 10,
• Klein MB , Yang H , DelBalso L , Carbonneau J , Frost E , Boivin G. (2010). Viral pathogens including human metapneumovirus are the primary cause of febrile respiratory illness in HIV-infected adults receiving antiretroviral therapy. The Journal of infectious diseases, 201(2),
• Nazemi E, Aithal S, Hassen WM, Frost EH, Dubowski JJ. GaAs/AlGaAs heterostructure based photonic biosensor for rapid detection of Escherichia coli in phosphate buffered saline solution. Sensors and Actuators B: Chemical, Online, (Article publié).
• Bourgade K, Garneau H, Giroux G, Le Page AY, Bocti C, Dupuis G, Frost EH, Fülöp T Jr. β-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1. Biogerentology, (Epub), (Article sous presse).