Perreault, Nathalie

Professeure, Faculté de médecine et des sciences de la santé
FMSS Dép. d'immunologie et de biologie cellulaire

Coordonnées

Courriel


819-821-8000, poste 72124

Diplômes

(2002) Post-doctorate (Post doctorate). University of Pennsylvania.

(1998) Doctorate (Ph.D.). Université de Sherbrooke.

(1994) Master's Thesis (M.Sc. - Masters). Université de Sherbrooke.

(1992) Bachelor's (B.SC). Université de Sherbrooke.

Présentation

Sujets de recherche

Biological and Biochemical Mechanisms, Cell, Cell Signaling, Developmental Genetics, Digestive System.

Disciplines de recherche

Cell Biology, Gastroenterology.

Mots-clés

Autophagy, Cell-cell adhesion, Conditional knockout, Epith/mes. interactions, GI cytodifferentiation, Hedgehog signaling, Intestinal proliferation, Microenvironnement, Molecular genetics, Smad and Gli transcription factor.

Intérêts de recherche

The general objective of my laboratory is to better understand the genetics, molecular and cellular mechanisms involved in mesenchymal-epithelial cross talk in the gut. Our focus is predominantly to analyze the role of the Bone Morphogenetic Proteins (BMPs) signaling pathway in the development, in the control of proliferation and in the differentiation of gut epithelial cells. The identification of new genes or factors having key roles in signalization from the mesenchyme to the epithelium will allow a better understanding of the molecular mechanisms regulating gut physiopathologies such as inflammatory bowel diseases and tumorigenesis.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2009) Award for outstanding achievement. Int. J. of Oncology/ Int. J. of Molecular Medicine. (Distinction).

Financement

Grant. (Awarded). Principal Applicant. Mechanisms regulating autophagy in intestinal epithelial secretory cells. (2018-2023).

Grant. (Awarded). Co-applicant. The nuclear receptor HNF4A as a regulator of WNT ligands: biological impact of this novel interaction in gut diseases. (contribution 15%). (2018-2023).

Grant. (Awarded). Principal Applicant. Functional contribution of Bmp signaling pathway in the reprogramming of gastrointestinal reactive mesenchyme. (Contribution 90%). (2014-2019).

Grant. (Completed). Co-applicant. Role of the nuclear receptor corepressor-1 in blocking inflammatory gene expression (Contribution 50%). (2013-2018).

Grant. (Under Review). Principal Applicant. Biomolecular and biomechanical impact of Foxl1+ mesenchymal telocytes on epithelial cell behaviour in gut-related diseases. (2019-2014).

Publications

Articles de revue

  • Perreault N. (2018). Ulcerative Colitis–Associated Carcinoma: Epithelial SMAD4-Mediated Signaling Is a Key Guardian. Cellular and Molecular Gastroenterology and Hepatology, 6(3), 350-351. (Published).
  • Lepage D., Bélanger É., Jones C., Tremblay S., *Allaire J.M., Bruneau J., Asselin C., Perreault N., Menedez A., Gendron F.-P., Boudreau F. (2017). Gata4 is critical to maintaingut barrier function and mucosal integrity following epithelial injury. Scientific Reports, 9(6), 32759. (Published).
  • Latreille R, *Servant R, Darsigny M, Marcoux S, Jones C, Perreault N, Boudreau F. (2017). Transcription factor CUX1 is required for intestinal epithelial wound healing and targets the VAV2-RAC1 Signalling complex. Biochim Biophys Acta., 1864(12), 2347-235. (Published).
  • *Allaire J.M., *Roy S.A., *Ouellet C., *Lemieux E., Jones C., Paquet M., Boudreau F. and Perreault N. (2016). Bmp signaling in colonic mesenchyme regulates stroll microenvironment and protects from polyposis initiation. International Journal of cancer, 138(11), 2700-2712. (Published).
  • Gonneaud A, Turgeon N, Boudreau F, Perreault N, Rivard N, Asselin C. (2016). Distinct Roles for Intestinal Epithelial Cell-Specific Hdac1 and Hdac2 in the Regulation of Murine Intestinal Homeostasis. J. Cell. Physiol, 231(2), 436-448. (Published).
  • Lepage D, Bélanger É, Jones C, Tremblay S, *Allaire JM, Bruneau J, Asselin C, Perreault N, Menendez A, Gendron FP, Boudreau F. (2016). Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury. Scientific Reports, 9(6), 36776. (Published).
  • *Roy S.A., *Allaire J.M., *Ouellet C., *Maloum F., *Pomerleau V.,* Lemieux E., Babeu J.-P., *Rousseau J., Jones C., Paquet M., Garde-Granger P., Boudreau F. and Perreault N. (2016). Loss of mesenchymal bone morphogeneticprotein signaling leads to development ofreactive stroma and initiation of thegastric neoplastic cascade. Scientific Report, 9(6), 32759. (Published).
  • Coulombe G, Langlois A, De Palma G, Langlois MJ, McCarville JL, *Gagné-Sanfaçon J, Perreault N, Feng GS, Bercik P, Boudreau F1, Verdu EF, Rivard N. (2016). SHP-2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host-Microbiota Homeostasis. J cell. Physical., 23(1), 2529-2540. (Published).
  • *Gagné-Sansfaçon J., *Allaire J.M., Jones, C., Boudreau F., and Perreault N.,. (2014). Loss of Sonic Hedgehog leands to alteration inintestinal secretory cells maturation and decrease cell autophagy. PLoS One, 9(6), e98751. (Published).
  • Coulombe G, Leblanc C, Cagnol S, *Maloum F,* Lemieux E, Perreault N, Feng GS, Boudreau F, Rivard N. (2013). Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Moll. Cell Biol., 33(11), 2275-2284. (Published).
  • Turgeon N, Blais M, Gagné JM, Tardif V, Boudreau F, Perreault N, Asselin C. (2013). HDAC1 and HDAC2 restrain the intestinal inflammatory response by regulating intestinal epithelial cell differentiation. PLoS One, 8(9), e73785. (Published).
  • *Roy SA , *Langlois MJ , Carrier JC , Boudreau F , Rivard N , Perreault N. (2012). Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes. World journal of gastroenterology : WJG, 18(14), 1579-89. (Published).
  • *Maloum F , *Allaire JM , *Gagné-Sansfaçon J ,* Roy E , Belleville K , Sarret P , Morisset J , Carrier JC , Mishina Y , Kaestner KH , Perreault N. (2011). Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells. American journal of physiology. Gastrointestinal and liver physiology, 300(6), G1065-79. (Published).
  • *Allaire J., Darsigny M.,* Marcoux S.S., *Roy S.A.B., *Schmouth J.F., Umans L., Zwijsen A., Boudreau F. and Perreault N. (2011). Loss of Smad5 leads to disassembly of the apical junctional complex and increasing susceptibility to experimental colitis. AJP Gastro Liver Physiol., 300(6), G1065-G1079. (Published).
  • Darsigny M , Babeu JP , Seidman EG , Gendron FP , Levy E , Carrier J , Perreault N , Boudreau F. (2010). Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species. Cancer research, 70(22), 9423-33. (Published).
  • Lussier CR , Brial F , Roy SA , Langlois MJ , Verdu EF , Rivard N , Perreault N , Boudreau F. (2010). Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PloS one, 5(8), e12378. (Published).
  • Langlois MJ , Bergeron S , Bernatchez G , Boudreau F , Saucier C , Perreault N , Carrier JC , Rivard N. (2010). The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PloS one, 5(12), e15742. (Published).
  • Langlois MJ , Roy SA , Auclair BA , Jones C , Boudreau F , Carrier JC , Rivard N , Perreault N. (2009). Epithelial phosphatase and tensin homolog regulates intestinal architecture and secretory cell commitment and acts as a modifier gene in neoplasia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1835-44. (Published).
  • Lussier CR , Babeu JP , Auclair BA , Perreault N , Boudreau F. (2008). Hepatocyte nuclear factor-4alpha promotes differentiation of intestinal epithelial cells in a coculture system. American journal of physiology. Gastrointestinal and liver physiology, 294(2), G418-28. (Published).
  • *Auclair BA, *Benoit YD, Rivard N, Mishina Y, Perreault N. (2007). Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage. Gastroenterology, 133(3), 887-896.
  • Boudreau F, Lussier CR, Mongrain S, Darsigny M, Drouin JL, Doyon G, Suh ER, Beaulieu JF, Rivard N, Perreault N. (2007). Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia. FASEB J., 21(14), 3853-65. (Published).
  • Perreault N, Sackett SD, Katz JP, Furth EE, Kaestner KH. (2005). Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. Genes and Development, 19(3), 311-315. (Published).

Articles de conférence

  • *Veronique Pomerleau, *Vilcy Reyes-Nicolas,* Raphaelle Servant, Francois-Michel Boisvert, Michel Grandbois and Nathalie Perreault. (2018). American society for matrix Biology. (In Press).
  • *Servant, R, Jones, C, Boudreau F., Perreault N.,. (2018). Bmp singaling in Foxl1+ cells is a key to the intestinal stem cell niche homeostasis. Canadian Digestive Disease Week Winter Meeting. (Published).
  • *Reyes V., *Allaire J.M., *Pomerleau V., *Ouellet C., *Servant R., Garde-Granger P., Boudreau F., Perreault N. (2018). Mucus barrier integrity is impaired by a dysfunctional mesenchyme. Canadian Digestive Disease Week Winter Meeting. (Published).
  • *Ouellet C., Garde-Granger P., , Boudreau F., andPerreault N. (2018). TRP53 Early initiation of stomach neoplasia through dual deletion of mesenchymal BMP signaling and. Canadian Digestive Disease Week Winter Meeting. (Published).
  • *Servant R., *Allaire J.M., Garde-Granger P., Boudreau F., Perreault N.,. (2017). Alteration of colonic mesenchyme amplifies the loss of heterogenecity and the oncogeniceffects of tumor suppressor APC. AACR workshop; Advances in Modeling Cancer in Mice:Technology, Biology, and Beyond. (Accepted).
  • *Pomerleau V., Babeu J.-P., Boudreau F., and Perreault N.,. (2017). Bmpra1Dual deletion of epithelial / in mice impairs colonic mucosa identity. Canadian Digestive Disease Week Winter Meeting. (Published).
  • *Reyes-Nicolas V., *Allaire J.M., *Pomerleau V., *Ouellet C., *Servant R., Boudreau F., Perreault N.,. (2017). Impact of mesenchymal Bmp signaling in Ulcerative Colitis. Canadian Digestive Disease Week Winter Meeting. (Published).
  • *Reyes-Nicolas V., *Allaire J.M., *Pomerleau V., *Ouellet C., *Servant R., Boudreau F., Perreault N.,. (2017). Impact of mesenchymal Bmp signaling in UlcerativeColitis. Canadian Digestive Disease Week Winter Meeting. (Published).
  • *Reyes-Nicolas V., *Allaire J.M., *Pomerleau V., *Ouellet C., *Servant R., Boudreau F., Perreault N.,. (2017). Impact of mesenchymal Bmp signaling in UlcerativeColitis. Research Topics in GI disease XVI,. (Published).
  • *Servant R., *Ouellet C and Perreault N.,. (2017). Loss of Bmps signaling inFoxl1+ subepithelial myofibroblasts impairs specification and aturation of intestinal epithelial cells. Canadian Digestive Disease Week Winter Meeting. (Published).
  • *Servant R., *Ouellet C and Perreault N.,. (2017). Loss of Bmps signaling in Foxl1+ subepithelialmyofibroblasts impairs specification and maturation of intestinal epithelialcells. Canadian Research Topics in GI disease XVI,. (Published).
  • *Ouellet C., Garde-Granger P., Boudreau F., and Perreault N.,. (2017). Trp53Loss of mesenchymal Bmpssignaling synergizes with mutation to induce gastric oncogenic progression. Canadian Digestive Disease Week Winter Meeting. (Published).
  • *Ouellet C., Garde-Granger P., Boudreau F., and Perreault N.,. (2017). Trp53Loss of mesenchymal Bmpssignaling synergizes with mutation to induce gastric oncogenic progression. Canadian Research Topics in GI disease XVI,. (Published).
  • Perreault N. (2016). Impact of Bmp signaling in the development ofcolonic reactive mesenchyme and polyposis initiation. Neuroimmunophysiology of the Gastrointestinal Tract 2016. (Published).
  • Perreault N. (2015). Loss of BoneMorphogenetic Proteins Signaling CascadeWithin Mesenchymal Cells Acts as a Trigger in Gastric Tumorigenesis Initiation. Gastric/Stomach Cancer and MALT Lymphoma. Session at The 1st Annual World Congress of Digestive Diseases. (Published).
  • Perreault N. (2015). Loss of BoneMorphogenetic Proteins Signaling Cascade Within Mesenchymal Cells Acts as a Trigger in Gastric Tumorigenesis Initiation. 1st Annual World Congress of Digestive Diseases. (Published).
  • *Allaire J., *Gagné-Sansfaçon J., Jones C., Boudreau F., and Perreault N. (2015). Loss of Sonic Hedgehog leads to alterations inintestinal secretory cell maturations and autophagy. Canadian Digestive Disease Week Winter Meeting. (Published).
  • *Allaire J, *Roy S, *Lemieux E, Jones C, Boudreau F, Perreault N. (2015). Loss of mesenchymal Bmp signaling is a keycomponent in myofibroblast expansion leading to the production of a primed stromaprompting to colonic polyposis. FASEB Summer Conference : GI tract XVI. (Published).
  • *Allaire J.M., *Roy S., Jones C., Keastner K.H., and Perreault N. (2015). Mesenchymal BMP signaling is a key component in thedevelopment of Cancer-Associated-Fibroblasts leading to colonic polyposisinitiation. Canadian Digestive Disease Week Winter Meeting. (Published).
  • Beaurivage C., Simoneau A., St-Jean S., Tremblay S., Boudjadi S.,* Allaire J., *Roy S., Carrier J., Boudreau F., Menendez A., Perreault N., Ilangumaran S. and Saucier C. (2015). The role of SOCS1 inintestinal homeostasis and colorectal carcinogenesis. Research Topics in GI Disease. (Published).
  • *Langlois M.J., *Maloum F.,* Roy S.B., Kaestner K.H., Carrier J., Boudreau, F. Rivard N., and Perreault N. (2014). Role of mesenchymal-associated Pten signaling inintestinal homeostasis and tumorigenesis. 19th World Congress on Advances in Oncology. (Published).
  • *Emond-Boisjoly M.-A., *Roy E., Babeu J.-P., Boudreau F., Perreault N. (2013). Combinatory role of Pten and BMP signalling onestablishment of the colonic mucosa identity. Canadian Digestive Disease Week,. (Published).
  • *Maloum, F., *Langlois M.-J., *Roy S.A.B., Kaestner K.H., Perreault N. (2013). Distinctive roles of epithelial and mesenchymal Pten in gastric tumorigenesis. American Society for Cell Biology. (Published).
  • *Allaire J., *Roy SAB., Kaestner K.H., Boudreau F., Perreault N. (2013). Loss of colonic myofibroblast BMP signalling stimulates matrix deposition and promote a myofibroblastic pro-fibrotic phenotype. Canadian Digestive Disease Week. (Published).
  • *Langlois M.J., *Roy S.A., *Roy E., Carrier JC., Perreault N., Boudreau F., Rivard N. (2013). Role of Pten and p27 tumor suppressors inintestinal morphogenesis and neoplasia. Phosphoinositide biology, signalling and cancer (IRIC international symposium). (Published).
  • *Roy SAB., *Allaire J., Kaestner K.H., Perreault N. (2013). Stromal BMP signalling negatively regulates gastric neoplasia. Digestive Disease Week. (Published).
  • *Roy SAB., *Allaire J., Kaestner K.H., Perreault N. (2013). Stromal BMP signalling negatively regulatesgastric neoplasia. Canadian Digestive Disease Week. (Published).
  • *Langlois M.J.,* Roy S.A.,* Roy E., Boudreau F., Rivard N., Perreault N. (2012). . Impact de la délétion stromale de Pten surl’homéostasie et la tumorigénèse intestinale. . Congrès de Signalisation Québec. (Published).
  • *Allaire J., *Roy SAB., Kaestner K.H., Boudreau F., Perreault N. (2012). Bmp signaling in colonic myofibrobroblasts impact on the subepithelial microenvironnement prompting epithelial dysplasia. Canadian Digestive Disease Week. (Published).
  • Perreault N. (2012). Distinctive roles for epithelial and mesenchymalBMP signaling in gut homeostasis. invited speaker by University of Pennsylvania, Children’s Hospital of Philadelphia, December 4, 2012. (Published).
  • Perreault N. (2012). Gastric BMP signaling : when the mesenchyme plays the bad guy. Symposium CAG Basic Science Session on Gastrointestinal tumorigenesis. CDDW/CASL Winter Meeting. (Published).
  • *Maloum F., *Roy SAB., Langlois MJ., Perreault N. (2012). Loss of epithelial PTEN affect gastric homeostasis and leads to spamolytic polypeptide-expressing metaplasia in themouse. AACR annual meeting. (Published).
  • *Allaire J., *Roy SAB., Kaestner K.H., Boudreau F., Perreault N. (2012). Microenvironemental deregulation following loss of stromal BMP signaling impact on colonic epithelial homeostasis. Keystone Symposia, The Role of Inflammation during Carcinogenesis. (Published).
  • *Langlois M.J.,* Roy SAB., *Roy E., Perreault N., Boudreau F., and Rivard N. (2012). Role of Pten and p27 tumor suppressors inintestinal morphogenesis and neoplasia. Digestive Disease Week. (Published).
  • *Maloum F., *Roy SAB., *Langlois MJ., Perreault N. (2012). Role of epithelial PTEN on gastric architecture, proliferation and cell specification in the mouse. Research topics in GI disease XI. (Published).
  • *Gagné-Sansfacon J., Ménard D., and Perreault N. (2012). Sonic hedgehog signaling is critical for goblet and Paneth cells terminal differentiation and protects against intestinal inflammation. Research topics in GI disease XI. (Published).
  • *Gagné-Sansfaçon J., Ménard D., and Perreault N. (2012). Sonic hedgehog signaling is critical for goblet and Paneth cells terminal differentiation and protects against intestinal inflammation. Canadian Digestive Disease Week,. (Published).
  • *Allaire JM, *Roy SA., Keastner KH., Boudreau F, Perreault N. (2011). BMP signaling in intestinal subepithelial myofibrobroblasts impacts on intestinal inflammation. 1st international symposium on the physiopathology and diseases of the digestive tract. (Published).
  • *Allaire JM, *Roy SA, Boudreau F, Perreault N. (2011). Bmp signaling in intestinal subepithelial myofibrobroblasts impacts on intestinal inflammation. Canadian Digestive Disease Week. (Published).
  • *Allaire JM, *Roy, SA, Boudreau F, Perreault N. (2011). Bmp signaling in intestinal subepithelial myofibrobroblasts impacts on intestinal inflammation. Research topics in GI disease X. (Published).
  • Perreault N. (2011). Gastric BMP signaling : when mesenchyme and epithelium tells a different story. 1st international symposium on the physiopathology and diseases of the digestive tract. (Published).
  • *Allaire JM, *Roy SA, Boudreau F, Perreault N. (2011). La signalisation des Bmps au niveau des myofibroblastes subépithéliaux influence l’inflammation intestinale. 79e Congrès de l’Acfas. (Published).
  • *Maloum F.,* Allaire J., *Sansfacon J.G., Carrier JC., Morisset J. and Perreault N. (2011). La voie de signalisation des Bmps est nécessaire à la specification cellulaire et aux functions épithéliales gastriques. 79e Congrès de l’Acfas. (Published).
  • *Allaire JM, *Roy SA., Keastner KH., Boudreau F, Perreault N. (2011). Loss of BMP signaling in subepithelial myofibrobroblasts leads to colonic dysplasia and impacts on ulcerative colitis. 14th International Symposium on Molecular Medicine. (Published).
  • Perreault N. (2011). Loss of BMP signaling in sub epithelial myofibrobroblasts leads to colonic dysplasia and impacts on ulcerative colitis. 14th International Symposium on Molecular Medicine.
  • *Sansfacon J.G., *Allaire J., Ménard D. and Perreault N. (2011). Rôle protecteur de Sonic Hedgehog dans la colite ulcéreuse. 79e Congrès de l’Acfas,. (Published).
  • Perreault N. (2011). Signalisation mésenchymateuse régulant les fonctions épithéliales digestives. Colloque :La régulation des fonctions de l’épithélium digestif : du récepteur membranaire à l’expression génique. 79e Congrès de l’Acfas. (Published).
  • *Roy SA, Kaestner KH, Perreault N. (2011). Stromal Bone Morphogenetic Proteins signaling dysregulation initiate gastric dysplasia. 1st international symposium on the physiopathology and diseases of the digestive tract. (Published).
  • Maloum F., Auclair B.A., Carrier J.C., Perreault N. (2010). BMP signaling in gastric homeostasis. Canadian Digestive Disease Week. (Published).
  • Maloum F., Allaire J., Morisset J., Carrier JC and Perreault N. (2010). BMP signaling is required for proper specification of epithelial cell lineages but is not involved in development of gastric neoplasia. 13th International Symposium on Molecular Medicine. (Published).
  • Maloum F., Auclair B.A. Carrier J.C., Perreault N. (2010). Bmp signaling is essential for the organogenesis, glandular architecture and specification of gastric epithelium in the mouse. Digestive Disease Week. (Published).
  • Langlois M.J., Boudreau F., Perreault N., Chababi W., Saucier C., Carrier J.C., and Rivard N. (2010). Effect of Pten downreglation on invasionand tumorigenic/metastatic potential of human colon cancer cells. Digestive Disease Week. (Published).
  • Darsigny, M., Babeu, J.-P., Lévy, E., Seidman, E.G., Gendron, F.P., Carrier J., Perreault, N., Boudreau, F. (2010). HNF4alpha protects against reactive oxygen species and promotes gut neoplasia. Digestive Disease Week. (Published).
  • Darsigny, M., Babeu, J.-P., Lévy, E., Seidman, E.G., Gendron, F.P., Carrier J., Perreault, N., Boudreau, F. (2010). Loss of HNF4-alpha increases oxidative stress and inhibits neoplasia in the gut. Canadian Digestive Disease Week. (Published).
  • Allaire J., Darsigny M., Marcoux S.S., Schmouth J.-F., Zwijsen A., Boudreau F. and Perreault N. (2010). Loss of Smad5 disrupts the intestinal barrier by disassembling the apical jnctional complex and increasing susceptibility to experimental colitis. Digestive Disease Week. (Published).
  • Allaire J., Darsigny M., Marcoux S.S., Schmouth J.-F., Umans L., Benoit Y.D., Mishina Y., Zwijsen A., Boudreau F. and Perreault N. (2010). Loss of Smad5 disrupt the intestinal epithelial barrier by disassembling the apical junctional complex and increasing susceptibility to experimental colitis. Canadian Digestive Disease Week. (Published).
  • Roy S, Carrier J.C., Perreault N. (2010). Role of epithelial intestinal Pten phosphatase in enteroendocrine cell specification. Canadian Digestive Disease Week. (Published).
  • Marcoux S., Allaire J. and Perreault N. (2010). Rôle distinct des divers Br-Smads au sein de l’épithélium intestinal. CRCQ. (Published).
  • Gagné-Sansfaçon J., Allaire J., Simoneau A., Ménard D. et Perreault N. (2010). Rôle protecteur de Sonic Hegehog dans la colite ulcéreuse. CRCQ. (Published).
  • Allaire J., Darsigny M., Marcoux S.S., Roy E., Boudreau F. and Perreault N. (2010). Smad5 régule l’assemblage du complexe apical de jonctions dans l’épithélium intestinal. Signalisation Québec. (Published).

Autres contributions

Cours enseignés

Gestion d'évènements

  • President. Comité d'éthique animale. (Association).

Présentations

  • (2018). Subepithelial mesenchymal cells, Trigger of GI diseases?. Kananaskis Inflammation Workshop 2018. Banff, Canada.
  • (2017). A Key Role for Stromal Bone Morphogenetic Proteins Signaling Cascade Deregulation in Triggering Gastrointestinal Diseases. the PCS 2nd Global Cell Science and Stem Cell Conference. Rome, Italy.
  • (2016). Bmp signaling in the regulation of a colonic reactive mesenchyme. Neurolmmuno Physiology of the Gastrointestinal Tract. Banff, Canada.
  • (2016). Impact of Bmp signaling in the development of gastric reactive mesenchyme and initiation of the neoplastic cascade. 2016 IUPHAR-GI on drug Development and New Frontier in Gastrointestinal diseases. Novigrad, Croatia.
  • (2015). Loss of Bone Morphogenetic Proteins Signaling Cascade Within Mesenchymal Cells Acts as a Trigger in Gastric Tumorigenesis Initiation. The 1st Annual World Congress of Digestive Diseases-2015. Nanjing, China.
  • (2014). So you want to flox that gene : Which Cre-line should you use. Small Group Session CDDW/CASL Winter Meeting. Toronto, Canada.
  • (2013). Distinctive roles for epithelial and mesenchymal PTEN signaling in colorectal cancer. University of Toronto, Hospital for Sick Children. Toronto, Canada.
  • (2013). Impact of BMP signaling in intestinal inflammation. University of Toronto, Mount Sinai Hospital. Toronto, Canada.
  • (2012). Bone morphogenetic proteins and epithelial-mesenchymal interactions in inflammation and cancer. Symposium CAG Basic Science Session on The Epithelium out of control: Communicating with Internal and External Environments.CDDW/CASL Winter Meeting. Montreal, Canada.
  • (2012). Distinctive roles for epithelial and mesenchymal BMP signaling in gut homeostasis. FAll Seminar, University of Pennsylvania, Children’s Hospital of Philadelphia. Philadelphia, United States.
  • (2010). Intestinal phenotyping in transgenic mice model. QRNT’s 6th Symposium “Focus on new transgenic models and their phenotyping”. Montreal, Canada.