Professeure, Faculté de médecine et des sciences de la santé
FMSS Dép. d'immunologie et de biologie cellulaire
(2002) Post-doctorate (Post doctorate). University of Pennsylvania.
(1998) Doctorate (Ph.D.). Université de Sherbrooke.
(1994) Master's Thesis (M.Sc. - Masters). Université de Sherbrooke.
(1992) Bachelor's (B.SC). Université de Sherbrooke.
Biological and Biochemical Mechanisms, Cell, Cell Signaling, Developmental Genetics, Digestive System.
Cell Biology, Gastroenterology.
Autophagy, Cell-cell adhesion, Conditional knockout, Epith/mes. interactions, GI cytodifferentiation, Hedgehog signaling, Intestinal proliferation, Microenvironnement, Molecular genetics, Smad and Gli transcription factor.
The general objective of my laboratory is to better understand the genetics, molecular and cellular mechanisms involved in mesenchymal-epithelial cross talk in the gut. Our focus is predominantly to analyze the role of the Bone Morphogenetic Proteins (BMPs) signaling pathway in the development, in the control of proliferation and in the differentiation of gut epithelial cells. The identification of new genes or factors having key roles in signalization from the mesenchyme to the epithelium will allow a better understanding of the molecular mechanisms regulating gut physiopathologies such as inflammatory bowel diseases and tumorigenesis.
Centre de recherche du CHUS
Grant. (Awarded). Principal Applicant. Mechanisms regulating autophagy in intestinal epithelial secretory cells. (2018-2023).
Grant. (Awarded). Co-applicant. The nuclear receptor HNF4A as a regulator of WNT ligands: biological impact of this novel interaction in gut diseases. (contribution 15%). (2018-2023).
Grant. (Awarded). Principal Applicant. Functional contribution of Bmp signaling pathway in the reprogramming of gastrointestinal reactive mesenchyme. (Contribution 90%). (2014-2019).
Grant. (Completed). Co-applicant. Role of the nuclear receptor corepressor-1 in blocking inflammatory gene expression (Contribution 50%). (2013-2018).
Grant. (Under Review). Principal Applicant. Biomolecular and biomechanical impact of Foxl1+ mesenchymal telocytes on epithelial cell behaviour in gut-related diseases. (2019-2014).