Labbé, Simon

Professeur, Faculté de médecine et des sciences de la santé
FMSS Dép. de biochimie et de génomique fonction.

Coordonnées

Courriel


819-821-8000, poste 75460


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Diplômes

(1999) Postdoctorat (Postdoctorat). University of Michigan.

(1995) Doctorat (Ph. D.). Université Laval.

(1989) Maîtrise avec mémoire (Maîtrise - Maîtrise). Université Laval.

(1987) Baccalauréat (Baccalauréat). Université Laval.

Titres de compétence

Professor. Université de Sherbrooke.

Présentation

Sujets de recherche

Désordres métaboliques, Désordres nutritionnels, Expression et régulation génique, Génétique moléculaire, Infections fongiques.

Disciplines de recherche

Biochimie, Biologie cellulaire, Biologie moléculaire, Microbiologie.

Mots-clés

Analyses par micropuces, Génétique des levures, Germination fongique, Homéostasie de l'hème, Homéostasie du cuivre et du fer, Homéostasie du fer, Levures, Métallochaperones, Métalloenzymes, Métallorégulateurs, Programmes cellulaires tels mitose et méiose, Routage des ions, Transport et routage d'ions métalliques.

Intérêts de recherche

Élucidation des mécanismes moléculaires du transport et du maintien de l'homéostasie des oligo-éléments essentiels tels le Cu, Fe et l'hème. Les modes de fonctionnement ainsi que les aspects structuraux des protéines régulatrices et de transport sont étudiés. Ces mécanismes sont étudiés à la fois au cours de la division cellulaire mitotique, de la différenciation méiotique et de la germination fongique. D'autre part, les mécanismes conférant des avantages pour les levures pathogènes au détriment des cellules hôtes qu'elles infectent sont également l'objet de plusieurs travaux dans le laboratoire.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2020) College of reviewers / Collège des évaluateurs des IRSC / CIHR. Canadian Institutes of Health Research (CIHR/IRSC). (Distinction).
  • (2016) Dean's honor for Professors and their Research Excellence. Recognition honor given by the Faculty of Medicine / Faculté de médecine et des sciences de la santé. Faculté de médecine et des sciences de la santé. (Honneur).
  • (2011) Senior Scientist Scholarship from Fonds de la Recherche en Santé du Québec (FRSQ) / Bourse de chercheur-boursier Senior. Fonds de recherche du Québec - Santé (FRQS). (Prix / Récompense).
  • (2009) Prix Pierre-et-Danielle-Bourgaux Award, Research Excellence Recognition Award given by the Faculty of Medicine / Faculté de médecine et des sciences de la santé. Université de Sherbrooke. (Distinction).
  • (2009) Prix AGES Mention de reconnaissance pour l’excellence de l’enseignement au 1er cycle par l’Association Générale des Étudiants de Sciences de l’Université de Sherbrooke. Université de Sherbrooke. (Distinction).
  • (2008) Prix AGES Mention de reconnaissance pour l’excellence de l’enseignement au 1er cycle par l’Association Générale des Étudiants de Sciences de l’Université de Sherbrooke. Université de Sherbrooke. (Distinction).
  • (2008) Scientist Junior II from Fonds de la Recherche en Santé du Québec (FRSQ) / Bourse de chercheur-boursier Junior II. Fonds de recherche du Québec - Santé (FRQS). (Prix / Récompense).
  • (2006) New Investigator Scholarship from Canadian Institutes of Health Research (CIHR) / Bourse pour Nouveau Chercheur des Instituts de recherches en santé du Canada (IRSC). Instituts de recherche en santé du Canada. (Prix / Récompense).
  • (2003) Junior I Scholarship from Fonds de la Recherche en Santé du Québec (FRSQ) / Bourse de chercheur-boursier Junior I. Fonds de recherche du Québec - Santé (FRQS). (Prix / Récompense).

Financement

Subvention. (Obtenu). Chercheur principal. Deciphering heme-iron homeostasis using the fission yeast model.. (2015-2020).

Subvention. (Obtenu). Demandeur principal. Key roles for metal-dependent proteins in meiotic differentiation.. (2017-2018).

Subvention. (Obtenu). Demandeur principal. Études structurales et fonctionnelles d’une nouvelle classe de protéines transportant l’hème.. (2015-2018).

Subvention. (Terminé). Chercheur principal. Development of serodiagnostic biomarkers for Candidemia.. (2016-2017).

Subvention. (Terminé). Demandeur principal. Nouveau biomarqueur pour contrer les fungémies.. (2015-2017).

Subvention. (Terminé). Chercheur principal. New roles for copper metabolism proteins in meiotic differentiation.. (2011-2016).

Subvention. (Terminé). Demandeur principal. Approche translationnelle pour la détection et le traitement des candidoses systémiques.. (2015-2016).

Subvention. (Terminé). Co-chercheur. High throughput protein immunolocalization analysis through virtual fluorescence imaging.. (2015-2016).

Subvention. (Terminé). Chercheur principal. Innovative and flexible tools for protein purification and molecule binding studies.. (2014-2015).

Subvention. (Terminé). Chercheur principal. Molecular control of iron-sensing in yeast.. (2010-2015).

Subvention. (Terminé). Co-chercheur. Development of department-wide bioinformatics solutions and their integration with experimental approaches.. (2011-2013).

Subvention. (Terminé). Chercheur principal. Molecular control of iron-sensing in yeast - Régulation de l'homéostasie du fer chez l'organisme modèle S. pombe. NSERC's Discovery Accelerator Supplements (DAS). (2010-2013).

Publications

Articles de revue

  • Normant, V., Mourer, T., and Labbé, S. (2018). The major facilitator transporter Str3 is required for low-affinity heme acquisition in Schizosaccharomyces pombe. Journal of Biological Chemistry, Epub ahead of print, March 16 2018., 293, 1-10. (Article publié).
  • Plante, S., Normant, V., Ramos-Torres, K. M., and Labbé, S. (2017). Cell-surface coppertransporters and superoxide dismutase 1 are essential for outgrowth duringfungal spore germination. Journal of Biological Chemistry, 292, 11896-11914. (Article publié).
  • Dlouhy, A. C., Beaudoin, J., Labbé, S., and Outten, C. E. (2017). Schizosaccharomyces pombe Grx4 regulates the transcriptional repressorPhp4 via [2Fe-2S] cluster binding. Metallomics, 9, 1096-1105. (Article publié).
  • Mourer, T., Normant, V., and Labbé, S. (2017). Schizosaccharomyces pombeHeme assimilation in requires cellsurface-anchored protein Shu1 and vacuolar transporter Abc3. Journal of Biological Chemistry, 292, 4898-4912. (Article publié).
  • Bird AJ and Labbé S. (2017). The Zap1 transcriptional activator negatively regulates translation of the RTC4 mRNA through the use of alternative 5' transcript leaders. Molecular Microbiology, 106, 673-677. (Article publié).
  • Ioannoni, R., Brault, A., and Labbé, S. (2016). Cuf2 is a transcriptional co-regulator that interacts with Mei4 for timely expression of middle-phase meiotic genes. PLoS One, 11(3), e0151914. (Article publié).
  • Brault, A., Rallis, C., Normant, V., Garant, J.M., Bahler, J., and Labbé, S. (2016). Php4 is a key player for iron economy in meiotic and sporulating cells. G3 - Genes/Genomes/Genetics, 6(10), 3015-3034. (Article accepté).
  • Normant, V., Beaudoin, J., and Labbé, S. (2015). An antisense RNA-mediated mechanism eliminates a meiosis-specific copper-regulated transcript in mitotic cells. Journal of Biological Chemistry, 290(37), 22622-22637. (Article publié).
  • Brault, A., Mourer, T., and Labbé, S. (2015). Molecular basis of the regulation of iron homeostasis in fission and filamentous yeasts. IUBMB Life, 67(11), 1-15. (Article publié).
  • Mourer, T, Jacques, JF, Brault, A, Bisaillon, M, Labbé, S. (2015). Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe. Journal of Biological Chemistry, 290, 10176-10190. (Article publié).
  • Plante S , Ioannoni R , Beaudoin J , Labbé S. (2014). Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells. Journal of Biological Chemistry, 289(14), 10168-10181. (Article publié).
  • Khan, MGM, Jacques, JF, Beaudoin, J, and Labbé, S. (2014). Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4. PLoS One, 9, e110721 (pp 1-15). (Article publié).
  • Jacques, JF, Mercier, A, Brault, A, Mourer, T, and Labbé, S. (2014). Fra2 is a co-regulator for Fep1 inhibition in response to iron starvation. PLoS One, 9, e98959 (pp 1-12). (Article publié).
  • Beaudoin J , Ekici S , Daldal F , Ait-Mohand S , Guérin B , Labbé S. (2013). Copper transport and regulation in Schizosaccharomyces pombe. Biochemical Society Transactions, 41(6), 1679-1686. (Article publié).
  • Labbé S , Khan MG , Jacques JF. (2013). Iron uptake and regulation in Schizosaccharomyces pombe. Current Opinion in Microbiology, 16(6), 669-676. (Article publié).
  • Beaudoin J , Ioannoni R , Mailloux S , Plante S , Labbé S. (2013). Transcriptional regulation of the copper transporter Mfc1 in meiotic cells. Eukaryotic Cell, 12(4), 575-590. (Article publié).
  • Ioannoni R , Beaudoin J , Lopez-Maury L , Codlin S , Bahler J , Labbé S. (2012). Cuf2 is a novel meiosis-specific regulatory factor of meiosis maturation. PloS One, 7(4), e36338 (pp1-15). (Article publié).
  • Ioannoni, R, Beaudoin, J, and Labbé, S. (2012). Mfc1 is a new meiosis-specific transporter. / Mfc1 est un nouveau transporteur de cuivre dédié à la méiose. Médecine Sciences Amérique (MSA), 1, 1-6. (Article publié).
  • Beaudoin, J , Ioannoni, R , Labbé, S. (2012). Mfc1 is a novel copper transporter during meiosis. Communicative & Integrative Biology, 5(2), 118-121. (Article publié).
  • Vachon P , Mercier A , Jbel M , Labbé S. (2012). The monothiol glutaredoxin Grx4 exerts an iron-dependent inhibitory effect on Php4 function. Eukaryotic Cell, 11(6), 806-819. (Article publié).
  • Beaudoin J , Thiele DJ , Labbé S , Puig S. (2011). Dissection of the relative contribution of the Schizosaccharomyces pombe Ctr4 and Ctr5 proteins to the copper transport and cell surface delivery functions. Microbiology, 157(Pt 4), 1021-1031. (Article publié).
  • Jbel M , Mercier A , Labbé S. (2011). Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1. Eukaryotic Cell, 10(5), 629-645. (Article publié).
  • Beaudoin J , Ioannoni R , López-Maury L , Bähler J , Ait-Mohand S , Guérin B , Dodani SC , Chang CJ , Labbé S. (2011). Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells. Journal of Biological Chemistry, 286(39), 34356-34372. (Article publié).
  • Ioannoni R , Beaudoin J , Mercier A , Labbé S. (2010). Copper-dependent trafficking of the Ctr4-Ctr5 copper transporting complex. PloS One, 5(8), e11964 (pp 1-10). (Article publié).
  • Mercier A , Labbé S. (2010). Iron-dependent remodeling of fungal metabolic pathways associated with ferrichrome biosynthesis. Applied and Environmental Microbiology, 76(12), 3806-3817. (Article publié).
  • Labbé S. (2010). Simon Labbé's work on iron and copper homeostasis. World Journal of Biological Chemistry, 1(5), 196-200. (Article publié).
  • Pouliot B , Jbel M , Mercier A , Labbé S. (2010). abc3+ encodes an iron-regulated vacuolar ABC-type transporter in Schizosaccharomyces pombe. Eukaryotic Cell, 9(1), 59-73. (Article publié).
  • Mercier A , Labbé S. (2009). Both Php4 function and subcellular localization are regulated by iron via a multistep mechanism involving the glutaredoxin Grx4 and the exportin Crm1. Journal of Biological Chemistry, 284(30), 20249-20262. (Article publié).
  • Labbé S , Harrisson JF , Séguin C. (2009). Identification of sequence-specific DNA-binding proteins by Southwestern blotting. Methods in Molecular Biology, 543, 151-161. (Article publié).
  • Jbel M , Mercier A , Pelletier B , Beaudoin J , Labbé S. (2009). Iron activates in vivo DNA binding of Schizosaccharomyces pombe transcription factor Fep1 through its amino-terminal region. Eukaryotic Cell, 8(4), 649-664. (Article publié).
  • Peter C , Laliberté J , Beaudoin J , Labbé S. (2008). Copper distributed by Atx1 is available to copper amine oxidase 1 in Schizosaccharomyces pombe. Eukaryotic Cell, 7(10), 1781-1791. (Article publié).
  • Mercier A , Watt S , Bähler J , Labbé S. (2008). Key function for the CCAAT-binding factor Php4 to regulate gene expression in response to iron deficiency in fission yeast. Eukaryotic Cell, 7(3), 493-508. (Article publié).
  • LaRochelle O , Labbé S , Harrisson JF , Simard C , Tremblay V , St-Gelais G , Govindan MV , Séguin C. (2008). Nuclear factor-1 and metal transcription factor-1 synergistically activate the mouse metallothionein-1 gene in response to metal ions. Journal of Biological Chemistry, 283(13), 8190-8201. (Article publié).
  • Laliberté J , Labbé S. (2008). The molecular bases for copper uptake and distribution: lessons from yeast. Médecine Sciences (M/S), 24(3), 277-283. (Article publié).
  • Beaudoin J , Labbé S. (2007). Crm1-mediated nuclear export of the Schizosaccharomyces pombe transcription factor Cuf1 during a shift from low to high copper concentrations. Eukaryotic Cell, 6(5), 764-775. (Article publié).
  • Pelletier B , Mercier A , Durand M , Peter C , Jbel M , Beaudoin J , Labbé S. (2007). Expression of Candida albicans Sfu1 in fission yeast complements the loss of the iron-regulatory transcription factor Fep1 and requires Tup co-repressors. Yeast, 24(10), 883-900. (Article publié).
  • Labbé S , Pelletier B , Mercier A. (2007). Iron homeostasis in the fission yeast Schizosaccharomyces pombe. Biometals, 20(3-4), 523-537. (Article publié).
  • Mercier A , Pelletier B , Labbé S. (2006). A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe. Eukaryotic Cell, 5(11), 1866-1881. (Article publié).
  • Beaudoin J , Labbé S. (2006). Copper induces cytoplasmic retention of fission yeast transcription factor Cuf1. Eukaryotic Cell, 5(2), 277-292. (Article publié).
  • Beaudoin J , Laliberté J , Labbé S. (2006). Functional dissection of Ctr4 and Ctr5 amino-terminal regions reveals motifs with redundant roles in copper transport. Microbiology, 152(Pt 1), 209-222. (Article publié).
  • Laliberté J , Labbé S. (2006). Mechanisms of copper loading on the Schizosaccharomyces pombe copper amine oxidase 1 expressed in Saccharomyces cerevisiae. Microbiology, 152(Pt 9), 2819-2830. (Article publié).
  • Pelletier B , Trott A , Morano KA , Labbé S. (2005). Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. Journal of Biological Chemistry, 280(26), 25146-25161. (Article publié).
  • Laliberté J , Whitson LJ , Beaudoin J , Holloway SP , Hart PJ , Labbé S. (2004). The Schizosaccharomyces pombe Pccs protein functions in both copper trafficking and metal detoxification pathways. Journal of Biological Chemistry, 279(27), 28744-28755. (Article publié).
  • Znaidi S , Pelletier B , Mukai Y , Labbé S. (2004). The Schizosaccharomyces pombe corepressor Tup11 interacts with the iron-responsive transcription factor Fep1. Journal of Biological Chemistry, 279(10), 9462-9474. (Article publié).
  • Pelletier B , Beaudoin J , Philpott CC , Labbé S. (2003). Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system. Nucleic Acids Research, 31(15), 4332-4344. (Article publié).
  • Beaudoin J , Mercier A , Langlois R , Labbé S. (2003). The Schizosaccharomyces pombe Cuf1 is composed of functional modules from two distinct classes of copper metalloregulatory transcription factors. Journal of Biological Chemistry, 278(16), 14565-14577. (Article publié).
  • Bellemare DR , Shaner L , Morano KA , Beaudoin J , Langlois R , Labbé S. (2002). Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe. Journal of Biological Chemistry, 277(48), 46676-46686. (Article publié).
  • Pelletier B , Beaudoin J , Mukai Y , Labbé S. (2002). Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe. Journal of Biological Chemistry, 277(25), 22950-22958. (Article publié).
  • Bellemare DR , Sanschagrin M , Beaudoin J , Labbé S. (2001). A novel copper-regulated promoter system for expression of heterologous proteins in Schizosaccharomyces pombe. Gene, 273(2), 191-198. (Article publié).
  • Beaudoin J , Labbé S. (2001). The fission yeast copper-sensing transcription factor Cuf1 regulates the copper transporter gene expression through an Ace1/Amt1-like recognition sequence. Journal of Biological Chemistry, 276(18), 15472-15480. (Article publié).

Chapitres de livre

  • Labbé, S, Beaudoin, J, and Ioannoni, R. (2013). Copper transport in fungi. Metals in Cells in Encyclopedia of Inorganic and Bioinorganic Chemistry; ISBN 978-1-119-95323-4. (163-174). John Wiley & Sons. (Article publié).
  • Labbé, S, Harrisson, JF, and Séguin, C. (2009). Identification of sequence-specific DNA-binding proteins by Southwestern blotting. In Methods in Molecular Biology. Protein-DNA Interactions: Principles and Protocols 3rd ed. (151-161). Humana Press, Totowa, NJ. (Article publié).
  • Labbé, S., Beaudoin, J., Bellemare, D.R., and Pelletier, B. (2002). Regulatory responses to copper ions in fungi. Handbook of Copper Pharmacology and Toxicology. (571-587). Humana Press. (Article publié).

Articles de conférence

  • Mourer, T., Létourneau, D., Morency, L.-P., Najmanovich, R., Lavigne, P., Bisaillon, M., and Labbé, S. (2017). 2ième Prix de la Meilleure Affiche (over 65)Caractérisation biochimique du récepteur d’hème Shu1. 17e Symposium Annuel PROTEO. (Article accepté).
  • For simplicity, here, I listed only selected posters that were the most important. (2017). Over the past 7 years (2011-18), my students have presented 65 posters and/or short talks in International, National, Provincial, and Institutional Meetings. Between 2011 and 2018, 10 of my students received prizes for their poster/talk presentations. (Article accepté).
  • Normant, V., Mourer, T., and Labbé, S. (2017). Schizosaccharomyces pombe.Str3 is a new protein involved in heme transport in. 17e Symposium Annuel PROTEO. (Article accepté).
  • Mourer, T., Létourneau, D., Lavigne, P., Bisaillon, M., and Labbé, S. (2017). Selected among the top 6 best posters (over 170) of the Conference.Biochemical characterization of Shu1, a protein that mediates heme acquisition. 2017 Gordon Research Conference on the Cell Biology of Metals – Metals in physiology and disease. (Article accepté).
  • Mourer, T., Normant, V., Beaudoin, J., Grenier, C., Guay, M-P, Carignan, A., Valiquette, L., Bisaillon, M., and Labbé, S. (2017). Selected for a presentation.Développementde biomarqueurs pour la détection précoce de patients candidémiques. 59e Club de Recherches Cliniques du Québec (CRCQ). (Article accepté).
  • Normant, V., Mourer, T., and Labbé, S. (2017). Str3 is a hemoprotein involved in heme transport. 2017 Gordon Research Conference on the Cell Biology of Metals – Metals in physiology and disease. (Article accepté).
  • Mourer, T., Morency, L-P, Bisaillon, M., and Labbé, S. (2016). 1er Prix Meilleur Poster.L’homéostasie de l’hème chez Schizosaccharomyces pombe : une ouverture vers la clinique. Journée Phare 2016. (Article accepté).
  • Normant, V., Mourer, T., and Labbé, S. (2016). Implication de la protéine Str3 dans l’assimilation d’hème chez la levure Schizosaccharomyces pombe. Journée Phare 2016. (Article accepté).
  • Mourer, T., Jean-François Jacques, Martin Bisaillon, and Labbé, S. (2015). 1er Prix Meilleure Presentation orale.Shu1 and heme assimilation in Schizosaccharomyces pombe. Journée Phare 2015. (Article accepté).
  • Dlouhy, A. C., Labbé, S., Outten, C. E. (2015). Schizosaccharomyces pombe Grx4 forms a [2Fe-2S]cluster-bound complex with Php4 to inhibit its transcriptional function. 2015 Gordon Research Conference on the Cell Biology of Metals – Mechanisms from Microbes to Humans. (Article accepté).
  • Brault, A., Rallis, C., Bahler, J. and Labbé, S. (2015). Selected among the top 8 best posters (over 100) of the Conference.Characterization of the iron-responsive CCAAT-regulatory subunit Php4 in meiotic cells. 2015 Gordon Research Conference on the Cell Biology of Metals – Mechanisms from Microbes to Humans. (Article accepté).
  • Mourer, T., Jean-François Jacques, Martin Bisaillon, and Labbé, S. (2015). Shu1 and heme acquisition in fission yeast. 2015 Gordon Research Conference on the Cell Biology of Metals – Mechanisms from Microbes to Humans. (Article accepté).
  • Normant, V., Beaudoin, J., and Labbé, S. (2014). A novel gene is regulated in a copper- and Cuf1-dependent manner in meiotic cells. 9th International Copper Meeting – Copper in Biology. (Article accepté).
  • Khan, M.G.M., Jacques, J.F., and Labbé, S. (2014). Modulation of Php4 nuclear localization. 2014 FASEB Summer Research Conference – Trace Elements in Biology and Medicine. (Article accepté).
  • Dlouhy, A., Li, H., Mapolelo, D., Zhang, B., Labbé, S., Johnson, M.K., and Outten, C.E. (2014). One of three posters selected for best poster award.Investigating the roles of monothiol glutaredoxins in cellular iron homeostasis. 2014 FASEB Summer Research Conference – Trace Elements in Biology and Medicine. (Article publié).
  • Plante, S., Ioannoni, R., Beaudoin, J., and Labbé, S. (2014). Selected for a presentation.Copper transporters during meiotic differentiation. 2014 International Smyte Meeting on Yeast Transport and Energetics. (Article accepté).
  • Mourer, T., Jacques, J.F., Bisaillon, M., and Labbé, S. (2014). Selected for a presentation.Shu1, a novel protein requires for iron acquisition from heme. 2014 International Smyte Meeting on Yeast Transport and Energetics. (Article accepté).
  • Dlouhy, A., Labbé, S., and Outten C. (2013). An [2Fe-2S]cluster-bound complex is formed between Php4 and the monothiol glutaredoxin Grx4. 2013 Gordon Research Conference on the Cell Biology of Metals. (Article accepté).
  • Dlouhy, A., Labbé, S., and Outten C. (2013). S. pombe Grx4 forms a [2Fe-2S] cluster-bound complex with Php4 to inhibit its transcriptional function. 7th International Conference on Iron-sulfur Cluster Biogenesis and Regulation - Edition 2013. (Article accepté).
  • Ioannoni, R., Beaudoin, J., Lanthier, A., Lopez-Maury, L., Bahler, J., and Labbé, S. (2012). Cuf2, a novel meiosis-specific regulatory factor for meiosis maturation. 8th International Copper Meeting – Copper in Biology - Edition 2012. (Article accepté).
  • Plante, S., Beaudoin, J., and Labbé, S. (2012). Expression profiles of members of the copper transporter (Ctr) family during meiosis. 8th International Copper Meeting – Copper in Biology. Edition 2012. (Article accepté).
  • Vachon, P., Mercier, A., Jbel, M., Khan, Md G. M., and Labbé, S. (2012). Interactions between the iron-regulatory subunit Php4 and the glutaredoxin Grx4. 2012 FASEB Summer Research Conference – Trace Element Metabolism in Biology and Medicine. (Article accepté).
  • Ioannoni, R., Beaudoin, J., Lopez-Maury, L., Codlin, S., Bähler, J., and Labbé, S. (2011). Cuf2 functions in the timely repression of middle genes during meiotic differentiation. 6th International Fission Yeast Meeting - Edition 2011. (Article accepté).
  • Jbel, M., Mercier, A., and Labbé, S. (2011). Grx4 monothiol glutaredoxin acts as an inhibitory partner for the iron-dependent regulator Fep1. 6th International Fission Yeast Meeting - Edition 2011. (Article accepté).
  • Vachon, P., Mercier, A., Jbel, M., and Labbé, S. (2011). Iron-mediated inhibition of Php4 function requires the monothiol glutaredoxin Grx4. 6th International Fission Yeast Meeting - Edition 2011. (Article accepté).
  • Beaudoin, J., Ioannoni, R., López-Maury, L., Bähler, J., Ait-Mohand, S., Guérin, B., Chang, C. J., and Labbé, S. (2011). Mfc1 is a copper transporter that functions in fission yeast meiosis and sporulation. 2011 Cell Biology of Metals - Gordon Research Conference. (Article accepté).
  • Labbé, S., Beaudoin, J., Ioannoni, R., López-Maury, L., Bähler, J., Ait-Mohand, S., Guérin, B., Chang, C. J. (2011). Schizosaccharomyces pombe.Discovery of a novel meiosis-specific copper transporter in. 6th International Fission Yeast Meeting - Edition 2011. (Article accepté).
  • Ioannoni, R., Beaudoin, J., Lopez-Maury, L., Bähler, J., and Labbé, S. (2010). Cuf2, a meiosis-specific transcriptional regulator. 2010 International Copper Meeting – Copper in Biology. (Article publié).
  • Beaudoin, J., Lopez-Maury, L., Bähler, J., and Labbé, S. (2010). Selected for a presentation.Mfc1, a meiosis-specific copper transporter. International Copper Meeting – Copper in Biology. Edition 2010. (Article publié).
  • Ioannoni, R., Beaudoin, J., Mercier, A., and Labbé, S. (2010). Visualization of the Ctr4-Ctr5 copper transporting complex by bimolecular fluorescence complementation in fission yeast. 2010 FASEB Summer Research Conference – Trace Element Metabolism in Biology and Medicine. (Article publié).
  • Jbel, M., Mercier, A., Pelletier, B., Beaudoin, J., and Labbé S. (2009). Iron-regulated binding of Fep1 to chromatin. 2009 Cell Biology of Metals – Metal Metabolism and Diseases - Gordon Research Conference. (Article publié).
  • Mercier, A., and Labbé S. (2009). Php4 undergoes iron-regulated nuclear-cytoplasmic shuttling in a Grx4- and Crm1- dependent manner. 2009 Cell Biology of Metals – Metal Metabolism and Diseases - Gordon Research Conference. (Article publié).
  • Mourer, T., Normant, V., Beaudoin, J., Grenier, C., Guay, M-P, Carignan, A., Valiquette, L., Bisaillon, M., and Labbé, S. Practical development of immunological and nucleotide-based strategies for rapid diagnosis of candidemia. 2018 FASEB - Trace elements in biology & Medicine.

Autres contributions

Cours enseignés

  • Génétique fondamentale et appliquée. GNT-305. (2015-11-27). Université de Sherbrooke. Canada.
  • Biologie moléculaire. BIM-501. (2015-05-05). Université de Sherbrooke. Canada.
  • Clonage moléculaire. BCM-114. (2015-01-06). Université de Sherbrooke. Canada.
  • Éléments de protéomique. BCM-610. (2015-01-06). Université de Sherbrooke. Canada.

Présentations

  • (2018). Simon Labbé. ''Heme receptors as new biomarkers for early detection of candidemia''. 2018 FASEB Summer Research Conference – Trace Elements in Biology & Medicine. États-Unis.
  • (2017). Simon Labbé. ''Spotlight on Schizosaccharomyces pombe heme acquisition proteins''. 2017 Gordon Research Conference on the Cell Biology of Metals. États-Unis.
  • (2016). Simon Labbé. ''Homéostasie des oligos-éléments chez les espèces fongiques.''. Symposium Annuel Proteomeus - 2016. Sherbrooke, Canada.
  • (2014). Simon Labbé. ''Copper metabolism proteins in meiotic differentiation''. 9th International Copper Meeting on Copper in Biology. Vico Equense, Italie.
  • (2014). Simon Labbé. ''Copper transporters during meiotic differentiation.''. 2014 International Smyte Meeting on Yeast Transport and Energetics. Montréal, Canada.
  • (2013). Découverte d’un nouveau transporteur méiotique. Symposium Simon-Pierre-Noël du Département de biochimie de l’Université de Montréal. Montreal, Canada.
  • (2013). Molecular control of the meiosis-specific copper transporter Mfc1. 7th International Fission Yeast Meeting – Pombe 2013. EMBO Conference. London, Royaume-Uni.
  • (2013). Simon Labbé. ''Iron homeostasis in the model eukaryote S. pombe.''. 2013 Gordon Research Conference on the Cell Biology of Metals. Newport, Salve Regina University, États-Unis.
  • (2013). Simon Labbé. ''Mfc1 function and regulation during meiosis.''. University Concordia as part of the life sciences seminar series. Montreal, Canada.
  • (2012). Regulation of meiosis-specific copper transporter gene expression. 8th International Meeting on "Copper in Biology" – Copper 12. Alghero, Island of Sardinia, Italie.
  • (2012). Trace element transporters and permeases. 2012 FASEB – Trace element metabolism in biology and medicine. Steamboat, États-Unis.
  • (2012). Une nouvelle cuproprotéine requise lors de la méiose. Seminar series - CHUQ. Quebec, Canada.
  • (2011). Control of iron homeostasis in the fungus Schizosaccharomyces pombe. 2011 Meeting on Intra- and Inter Transport and Communication - IITC, Marburg, Germany. Marburg, Allemagne.
  • (2011). Molecular response to iron deficiency. Seminar Series - Department of Biology, Queen's University. Kingston, Canada.
  • (2010). Mfc1, a meiosis-specific copper transporter. 7th International Meeting on "Copper in Biology". Alghero, Island of Sardinia, Italie.
  • (2010). Visualization of the Ctr4-Ctr5 copper transporting complex by bimolecular fluorescence complementation in fission yeast. 2010 FASEB Summer Research Conference - Trace Element Metabolism in Biology & Medicine. Snowmass, États-Unis.
  • (2009). A new mechanism for preservation of iron in eukaryotic cells. Seminar series - Lady Davis Institute for Medical Research. Montreal, Canada.
  • (2009). Iron deficiency response in the model eukaryote Schizosaccharomyces pombe. 59th Annual Conference of the Canadian Society of Microbiologists – Microbial Metals: Acquisition and Utilization. Montreal, Canada.
  • (2008). A novel mechanism for the iron-sparing response. 2008 Annual Microbiological Society Meeting: Microbial Stress Response; prokaryotes and eukaryotes. Daejeon, Corée, République Populaire Démocratique de.
  • (2008). Guardians of metal homeostasis in Schizosaccharomyces pombe. 2008 Symposium of Stress Response of Eukaryotic Microorganisms. Seoul, Corée, République Populaire Démocratique de.
  • (2007). Metals in endocytic and internal compartments. 2007 Gordon Research Conference on the Cell Biology of Metals. Newport - Salve Regina University, États-Unis.