Bkaily, Ghassan

Professeur, Faculté de médecine et des sciences de la santé
FMSS Dép. d'immunologie et de biologie cellulaire

Coordonnées

Courriel


819-821-8000, poste 75303

Diplômes

(1984) Post-doctorate (Postdoct training). University of Cincinnati.

(1983) Post-doctorate (Postdoct training). University of Virginia.

(1982) Doctorate (Phylosophiae Doctorate). Université de Sherbrooke.

(1978) Master's Thesis (Master of Science - Masters). Université de Sherbrooke.

Expérience académique

(2016) Associate Professor. Alfaisal University, Riyadh, Saudi Arabia.

(2013-2017) Director of a Fonds de Recherche Nature et Technologie ( FQRNT) Research Team. Fonds de recherche du Québec - Nature et technologies (FRQNT).

(1994-2006) Director- Research Group of Excellence in Immuno-Cardiovascular Interactions. Université de Sherbrooke.

(1993-2002) Director of a CIHR Group on Immuno-Cardiovascular interactions. Canadian Institutes of Health Research.

Présentation

Sujets de recherche

Cardiomyopathy, Cardiovascular System, Hypertension, Electrophysiology, Cellular Aging, Arrhythmia, Atherosclerosis, Cardiac Fibrosis, Cardiovascular Diseases, Stroke, Toxin and Toxicant Metabolism.

Disciplines de recherche

Cardiology, Pharmacology, Cell Biology, Immunology, Molecular Biology.

Mots-clés

Calcium, Cardiovascular development and aging, Cardiovascular physiology, Cell signaling, Electrophysiology, Hypertension, Hypertrophy and heart failure, Ionic membrane transport, Nuclear function, Receptors.

Intérêts de recherche

Cardiovascular physiology, pathology and pharmacology, hypertension, hypotension, cardiac hypertrophy and heart failure, cardiomyopathy, calcium homeostasis.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2017) Executive Council Member of the International Academy of Cardiovascular Sciences- North American Section. International Academy of Cardiovascular Sciences- North American Section. (Distinction).
  • (2015) Associate Editor/ Canadian Journal of Physiology and Pharmacology. Canadian Journal of Physiology and Pharmacology. (Distinction).
  • 3 papers among top 10 most cited papers in his field. BioMedLib. (Distinction).
  • Associate Editor / European Journal of Physiology (Pfluger Archives). European Journal of Physiology (Pfluger Archives). (Distinction).
  • Editor-in-Chief/ Canadian Journal of Physiology and Pharmacology. Canadian Journal of Physiology and Pharmacology. (Distinction).
  • Fellow of the American Heart Association, USA. American Heart Association.
  • Fellow of the International Academy of Cardiovascular Sciences. International Academy of Cardiovascular Sciences. (Honor).
  • Ken Bowman Research Achievement Award, 17th Annual meeting, Institute of Cardiovascular Sciences, Winnipeg, Manitoba, Canada. Institute of Cardiovascular Sciences. (Prize / Award).
  • Most outstanding Pharmacology Paper in the year 2004 /Pharmacological Society of Canada. Prix honorifique annuel (2004) de la Société de pharmacologie du Canada (CJPP). (Distinction).
  • President, Organization committee, Congress of the International Academy of Cardiovascular Sciences- North American Section. International Academy of Cardiovascular Sciences- North American Section. (Distinction).
  • Ramesh K. Goyal Career Award in Cardiovascular Sciences, VII- International Conference of Recent Advances in Cardiovascular Sciences, International Academy of Cardiovascular Sciences, India Section, Amity University, Uttar Pradesh, India. VII- International Conference of Recent Advances in Cardiovascular Sciences, IACS. (Prize / Award).

Financement

Grant. (Awarded). Principal Applicant. Regulation of nuclear calcium and ROS by Angiotensin II in heart cells.. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grant Program. 125000 $ (2016-2022).

Publications

Articles de revue

  • Jacques , D. Provost, C., *Normand, A., *Abou Abdallah N., Al-Khoury, J., Bkaily, G. (2019). Angiotensin II induces apoptosis of human right and left ventricular endocardial endothelial cells by activating the AT2 receptor. Canadian Journal of Physiology and Pharmacology, 97(6), 581-588. (Published).
  • Jacques, D., and Bkaily, G. (2019). Endocardial endothelial cell hypertrophy takes place during the development of hereditary cardiomyopathy. Molecular and Cellular Biochemistry, 453(1-2), 157-161. (Published).
  • *Chamoun, M., Jacques, D., and Bkaily, G. (2019). Extracellular and intracellular tumor necrosis factor alpha modulates cytosolic and nuclear calcium in human cardiovascular cells. Canadian Journal of Physiology and Pharmacology, 97(9), 820-828. (Published).
  • Bkaily, G., *Najibeddine, W., and Jacques D. (2019). Increase of NADPH oxidase 3 in heart failure of hereditary cardiomyopathy. Canadian Journal of Physiology and Pharmacology, 97(9), 902-908. (Published).
  • Bkaily, G. Jazzar, A., Normand, A., Simon, Y., Al-Khoury, J., Jacques, D. (2019). Taurine and cardiac disease: state of the art and perspectives. Canadian Journal of Physiology and Pharmacology, doi: 10.1139/cjpp-2019-0313. [Epub ahead of print], (In Press).
  • Bkaily, G., *Simon, Y., *Menkovic, I., Bkaily, C., Jacques, D. (2018). High salt-induced hypertrophy of human vascular smooth muscle cells associated with a decrease in glycocalyx. Journal of Molecular and Cellular Cardiology, 125, 1-5. (Published).
  • *Hassan, G.S., Jacques, D., D'Orléans-Juste, P., Magder S., and Bkaily, G. (2018). Physical contact between human vascular endothelial and smooth muscle cells modulates cytosolic and nuclear calcium homeostasis. Canadian Journal of Physiology and Pharmacology, 96(7), 655-661. (Published).
  • *Kamal M, Jacques D, Bkaily G. (2017). Angiotensin II receptors' modulation of calcium homeostasis in vascular endothelial cells. Canadian Journal of Physiology and Pharmacology, 95(10), 1289-97. (Published).
  • Jacques D, Abdel-Karim Abdel-Malak N, *Abou Abdallah N, *Al-Khoury J, Bkaily G. (2017). Difference in the response to Angiotensin II between left and right ventricular endocardial endothelial cells. Canadian Journal of Physiology and Pharmacology, 95(10), 1271-82. (Published).
  • Carrier E, Houde M, Grandbois M, Bkaily G, Warner TD, D'Orléans-Juste P. (2017). Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice. Canadian Journal of Physiology and Pharmacology, 95(8), 954-960. (Published).
  • Bkaily G, Jacques D. (2017). Na+-H+ exchanger and proton channel in heart failure associated with Becker and Duchenne muscular dystrophies. Canadian Journal of Physiology and Pharmacology, 95(10), 1213-23. (Published).
  • Jacques D, D'Orleans-Juste P, Magder S, Bkaily G. (2017). Neuropeptide Y and its receptors in ventricular endocardial endothelial cells. Canadian Journal of Physiology and Pharmacology, 95(10), 1224-29. (Published).
  • *Mikhail M, Vachon PH, D'Orleans-Juste P, Jacques D, Bkaily G. (2017). Role of endothelin-1 and its receptors ETA and ETB in the survival of human vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology, 95(10), 1298-1305. (Published).
  • *Abdel-Samad, D, Bkaily G, Magder, S, and Jacques, D. (2016). ETA and ETB receptors contribute to NeuropeptideY-induced secretion of endothelin-1 in right but not left human ventricular endocardial endothelial cells. Neuropeptides, 55, 145-53. (Published).
  • *Semaan W, Desbiens L, Houde M, Labonté J, Gagnon H, Yamamoto D, Takai S, Laidlaw T, Bkaily G, Schwertani A, Pejler D, Levesque C, Desjardins R, Day R, D'Orléans-Juste P. (2015). Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase. Biochem. Pharmacol., 94(2), 91-100. (Published).
  • Bkaily G, *Chahine M, *Al-Khoury J, *Avedanian L, Beier N, Scholz W, Jacques D. (2015). Na+-H+ exchanger inhibitor prevents early death in hereditary cardiomyopathy. Can. Journal of Physiology and Pharmacology, 93(11), 923-34. (Published).
  • Jules F,*Avedanian L, *Al-Khoury J, *Keita R, *Normand A, Bkaily G and Jacques D. (2015). Nuclear membranes ETB receptors mediate ET-1-induced increase of nuclear calcium in human left ventricular endocardial endothelial cells. Journal of Cardiovascular Pharmacology, 66(1), 50-7. (Published).
  • Bkaily G, *Avedanian L, *Al-Khoury J, *Chamoun M, *Semaan R, *Jubinville-Leblanc C, D’Orléans-Juste P, Jacques D. (2015). Nuclear membranes R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. Can J Physiol Pharmacol, 93(4), 291-7. (Published).
  • *Ahmarani L, *Avedanian L, *Al-Khoury J, Perreault C, Jacques D, Bkaily G. (2013). Whole-cell and nuclear NADPH oxidases levels and distribution in human endocardial endothelial, vascular smooth muscle, and vascular endothelial cells. Can J Physiol. Pharmacol., 91(1), 71-9. (Published).
  • Bkaily G , *Avedanian L , *Al-Khoury J , Provost C , *Nader M , D'Orléans-Juste P , Jacques D. (2011). Nuclear membrane receptors for ET-1 in cardiovascular function. American Journal of Physiology, 300(2), R251-63. (Published).
  • *Avedanian L , Jacques D , Bkaily G. (2011). Presence of tubular and reticular structures in the nucleus of human vascular smooth muscle cells. Journal of Molecular and Cellular Cardiology, 50(1), 175-86. (Published).

Chapitres de livre

  • Ghassan Bkaily, Johny Al-Khoury, *Yanick Simon, Danielle Jacques. (2017). Intracellular free calcium measurement using confocal imaging. Rhian M. Touyz & Ernesto L. Schiffrin (Eds) Methods Molecular Biology Vol. 1527, Rhian M. Touyz and Ernesto L. Schiffrin (Eds): Hypertension (Rhian M. Touyz & Ernesto L. Schiffrin (Eds), 1527, 177-187). United Kingdom : Springer Nature. (Published).
  • Ghassan Bkaily and Danielle Jacques. (2017). Intracellular sodium overload in hereditary cardiomyopathy. Edts: Y. Kawai. A.R. Hargens and P.K. Single In: Adaptation Biology & Medicine (volume 8, Current Trends), Edts: Y. Kawai. A.R. Hargens and P.K. Single, Narosa Publishing House Pvt. Ltd. New Dehli,. India. (8, 61-66). Japan : Narosa Publishing House Pvt. Ptd. (Published).
  • Ghassan Bkaily and Danielle Jacques. (2013). Use of confocal microscopy to investigate cell structure and function. P. Michael Conn Techniques in confocal microscopy. P. Michael Conn Ed.pp 105-122. (P. Michael Conn, 105-122). United Kingdom : Elsevier. (Published).

Articles de conférence

  • *Abou Abdallah, N.,*Hassan, G., *Simon, Y., Jacques, D., Bkaily, G. (2018). Physical contact between vascular endothelial and smooth muscle cells mediates increase in intracellular calcium. 37th Annual conference of the North American Section of the International Society of Heart Research, Halifax Nova Scotia, May 29th -June1st 2018. (In Press).
  • *Simon Y, *Abou Abdallah N, Al-Khoury J, Jacques D, Bkaily G. (2017). Regulation of cytosolic and nuclear ROS and calcium by endothelin-1 in cardiovascular cells. 5th Forum to promote Young Investigator and Centers of Excellence in Cardiovascular Research, Annual Meeting of the North American Section of the international Academy of Cardiovascular Sciences (IACS). (Published).
  • Al-Khoury J, Jacques D, and Bkaily G. (2016). Angiotensin II receptors modulation of calcium homeostasis in human vascular endothelial cells. 4th Forum to promote Young Investigator and Centers of Excellence in Cardiovascular Research, Annual Meeting of the North American Section of the international Academy of Cardiovascular Sciences (IACS). (Published).
  • *Jubinville-Leblanc C, *Abdel-Samad A, *Normand A, Bkaily G, Jacques D. (2016). ETA and ETB receptors contribute to neuropeptide Y-induced secretion of endothelin-1 in right but not left human ventricular endocardial endothelial cells. 4th Forum to promote Young Investigator and Centers of Excellence in Cardiovascular Research, Annual Meeting of the North American Section of the international Academy of Cardiovascular Sciences (IACS). (Published).
  • *Semaan Rana, *Ahmarani Lena, *Jubinville-Leblanc Cynthia, Jacques Danielle and Bkaily Ghassan. (2015). Cell-dependent levels and distribution of NADPH oxidases. Annual Meeting of the International Academy of Cardiovascular Sciences: North American Section. (Published).
  • Al-Khoury Johny, Jacques Danielle and Bkaily Ghassan. (2015). Implication of the sodium-hydrogen exchanger type 1 NHE1 in thedevelopment of hypotension in hereditary cardiomyopathy. Annual meeting of the International Academy of cardiovascular Sciences: North American Section. (Published).
  • Bkaily Ghassan. (2015). Nuclear T-tubules as a marker and therapeutic target in hypertrophy and aging of human vascular smooth muscle cells. Indo-Canadian Symposium on Heart Failure: Progress & prospects, March 12-14 2015, Trivandium. (Published).
  • *Keita Ramatoulaye, Jules Farah, Al-Khoury Johny, Bkaily Ghassan, and Jacques Danielle. (2015). Nuclear membranes ETB receptors mediate ET-1-induced increase of nuclearcalcium in human endocardial endothelial cells. Annual Meeting of the International Academy of Cardiovascular Sciences: North American Section. (Published).
  • Bkaily, Ghassan. (2015). Role of Sodium-Hydrogen Exchanger in hypertrophy and heart failure in hereditary cardiomyopathy. 7th International Conference on «Recent Avances in Cardiovascular Sciences, March 10-11 2015, Amity University, Uttar Pradesh. (Published).
  • Bkaily, Ghassan. (2015). Structural adaptation in the nucleus as a marker and therapeutic target in human vascular smooth muscle cells. 11th World Congress of the International Society for Adaptative Medicine, May 27-30th 2015, Yonago Convention Center. (Published).
  • Bkaily, G., Jacques, D. (2013). Hereditary cardiomyopathy is also a vascular disease: The sodium-hydrogen exchanger a key common player?. International Academy of Cardiovascular Sciences. (Published).
  • Neugebauer WA, Houde M, Bkaily G, Labonté J, D'Orléans-Juste P. (2012). Heterofunctional dimer of endothelin ETA antagonist and ETB agonist «clicked» N-terminally on resin with second peptide component in solution. J. Peptide Science, 18, 32th European Peptide Symposium, Athens, Greece. (Published).
  • Jacques, D., Magder, S., D'Orléans-Juste, P., Bkaily, G. (2012). Human endocardial endothelial cells hypertrophy and release of endothelin-1: Role of Neuropeptide Y and Angiotensin II. 10th International NPY-PYY-PP Meeting. (Published).

Propriétés intellectuelles

Patents

  • Specific and highly potent R-type Ca2+ channel blocker, the 30th of September 1997 (No 2,217,088) (Inventors: Bkaily et al.). Canada. (Granted/Issued).
  • Specific and highly potent R-type Ca2+ channel blocker, the 30th of September 1997 (No 2,217,088) (Inventors: Bkaily et al.). Spain. (Granted/Issued).
  • Specific and highly potent R-type Ca2+ channel blocker, the 30th of September 1997 (No 2,217,088) (Inventors: Bkaily et al.). France. (Granted/Issued).
  • Specific and highly potent R-type Ca2+ channel blocker, the 30th of September 1997 (No 2,217,088) (Inventors: Bkaily et al.). United Kingdom. (Granted/Issued).
  • Specific and highly potent R-type Ca2+ channel blocker, the 30th of September 1997 (No 2,217,088) (Inventors: Bkaily et al.). United States. (Granted/Issued).
  • Specific and highly potent R-type Ca2+ channel blocker, the 30th of September 1997 (No 2,217,088) (Inventors: Bkaily et al.). Germany. (Granted/Issued).

Autres contributions

Gestion d'évènements

  • President. (2016). Annual meeting of the International Academy of Cardiovascular Sciences, North American Section, Sherbrooke, Quebec, Canada. (Conference).
  • Judge. (2015). Annual meeting of the International Academy of Cardiovascular Sciences, North American Section, Omaha, Nebraska, USA September 10-12th 2015. (Conference).
  • Chairman. (2009). ET-11: APS International Conference on Endothelin - Montréal, Québec. (Conference).
  • Chairman. (2009). 6th COSC: 6th Meeting of the Canadian Oxidative Stress Consortium - Winnipeg, Manitoba. (Conference).

Présentations

  • (2019). Heart failure in Duchenne and Becker Muscular Dystrophies: Where we are and where we are going. 6th Meeting of European Section and 7th Meeting of North American Section of the International Academy of Cardiovascular Sciences (IACS). Vrnjacka Banja, Serbia.
  • Bkaily, G. (2018). Cardiac defects in muscular dystrophy. 37th Annual conference of the North American Section of the International Society of Heart Research, Halifax Nova Scotia, May 29th -June1st 2018. Halifax, Canada.
  • Bkaily, G., and Jacques, D. (2018). Heart and vascular failures in Duchenne and Becker muscular dystrophies: where we are and where we are going. Joint Conference of the Central American and Caribbean Society of Cardiology, the Cuban Society of Cardiology and the North American Section of the International Academy of Cardiovascular Sciences. June 5-8th 2018. Havana, Cuba.
  • Bkaily, G. (2018). New concept for treatment of heart and vascular failures. 5th meeting of the International Academy of Cardiovascular Sciences – European Section- Advances ?n card?ovascular research: from basic mechanisms to therapeutic strategies, Congress Center of the Slovak Academy of Science, Bratislava,May 23-26 2018. Slovakia.
  • Bkaily, G. (2018). ROS or Anti-ROS, that is the question. 4th Congress of Physiological Sciences of Serbia, Current trends in physiological sciences: from cell signals to the biology of aging. Sept. 19-23, 2018. Serbia.
  • Bkaily, G. (2018). Role of sodium-hydrogen exchange in cardiovascular adaptation in hereditary cardiomyopathy. International Conference for Adaptations and Nutrition in Sports (ICANS), July 18-20 2018, Chonburi, Thailand. Thailand.
  • Bkaily, G. (2017). Calcium-dependent ROS generation in human vascular smooth muscle. VI International Symposium on Oxidative Stress and Cardiovascular Diseases, to be held at the Federal University of Rio Grande do Sul, Porto Alegre, Brazil, on November 17th., 2017. Porto Alegre, Brazil.
  • Bkaily, G. (2017). Heterodimerized endothelin-1 receptors: A novel role in ROS generation in human vascular smooth muscle cells. 5th Forum to promote Young Investigator and Centers of Excellence in Cardiovascular Research, Annual Meeting of the North American Section of the international Academy of Cardiovascular Sciences (IACS). Orlando, United States.
  • Bkaily, G. (2016). Sodium-Hydrogen exchanger blocker for the treatment of heart and vascular failures in Becker and Duchenne muscular dystrophy. 4th Forum to promote Young Investigator and Centers of Excellence in Cardiovascular Research, Annual Meeting of the North American Section of the international Academy of Cardiovascular Sciences (IACS). Sherbrooke, Canada.
  • Bkaily, G. (2015). Nuclear T-tubules as a marker and therapeutic target in hypertrophy and aging of human vascular smooth muscle. Indo-Canadian Symposium on Heart Failure: Progress & Prospects, Trivandrum, India, March 12-14 2015. Trivandium, India.
  • Bkaily, G. (2015). Role of ROS in regulation of calcium homeostasis. Congress of the Slovak Academy of Sciences, Smolenice castle, September 2-5th 2015, Bratislava, Slovakia. Bratislava, Slovakia.
  • Bkaily, G. (2015). Role of sodium-hydrogen exchanger in hypertrophy and heart failure of hereditary cardiomyopathy. 7th International Conference on «Recent advances in Cardiovascular Sciences», Amity University, Uttar Pradesh, India, March 10-11 2015. New Delhi, India.
  • Bkaily, G. (2015). Structural adaptation in the nucleus as a marker and therapeutic target in human vascular smooth muscle cells. 11th World Congress of the International Society for Adaptative Medicine, May 27-30th 2015, Yonago Convention Center. Yonago, Japan.
  • Bkaily, G. (2014). Hereditary cardiomyopathy is also a vascular disease. Second Cardiovascular Forum for Promoting Center of Excellences and Young Investigators. Winnipeg, Canada.
  • Bkaily, G. (2014). Identifying new targets for the treatment of hereditary cardiomyopathy. Cuban Congress of Cardiology. La Havana, Cuba.
  • Bkaily, G. (2013). Reactive oxygen species and loss of calcium homeostasis in the nucleus. Symposium - Pavlov Institute of Physiology (Mini-symposium Frontiers in Cardiac Pathophysiology and Therapies). St-Petersburg, Russian Federation.
  • Bkaily, G. (2011). Nuclear membranes G-proteins coupled receptors and nuclear T-tubules contribute to vascular smooth muscle cells function. XXXth Annual Meeting of the European Section of the International Society of Heart Research (ISAR) - Symposium 1: Calcium Remodelling in the Cardiomyocytes. Haifa, Israel.

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