Martin Nicolas Klein
Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de médecine
Présentation
Sujets, disciplines ou intérêts de recherche
Immunology, Asthma, Epithelium, Regulatory Cells, Exosomes, Organoid
Diplômes
- (2016-2019). PhD. Institut du Thorax. Nantes, France.
- (2014-2016). Master. Université de Tours. Tours, Centre-Val de Loire, France.
Expériences académiques
- Assistant Professor. (2025-). Université de Sherbrooke. Sherbrooke, Canada.
- Postdoctoral fellow. (2020-2024). Institut universitaire de cardiologie et de pneumologie de Québec. Quebec, QC, Canada.
Publications
Articles
- Victoria Lorant, Martin Klein, Damien Garçon, Thibaud Sotin, Samuel Frey, Marie-Aude Cheminant, Audrey Ayer, Mikaël Croyal, Laurent Flet, Antoine Rimbert, Luc Colas, Bertrand Cariou, Grégory Bouchaud, Cédric Le May. (2024). PCSK9 inhibition protects mice from food allergy. Translational Research. DOI
- Martin Klein, Pierre-Alexandre Gagnon, Mabrouka Salem, Mahmoud Rouabhia, Jamila Chakir. (2024). MiR-155-5p Differentially Regulates IL-13Rα1 and IL-13Rα2 Expression and Signalling, Driving Abnormal Lung Epithelial Cell Phenotype in Severe Asthma. American Journal of Respiratory Cell and Molecular Biology. DOI
- Martin Klein, Sophie Plante, Marie-Ève Boulay, Louis-Philippe Boulet, Jamila Chakir. (2023). Discrepancy in the suppressive function of regulatory T cells in allergic asthmatic vs. allergic rhinitis subjects upon low-dose allergen challenges. Frontiers in Allergy. DOI
- Pierre-Alexandre Gagnon, Martin Klein, John De Vos, Sabrina Biardel, Andréanne Côté, Krystelle Godbout, Michel Laviolette, Catherine Laprise, Said Assou, Jamila Chakir. (2023). S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty. Respiratory Research. DOI
- Pierre-Alexandre Gagnon, Andréanne Côté, Martin Klein, Sabrina Biardel, Michel Laviolette, Krystelle Godbout, Ynuk Bossé, Jamila Chakir. (2023). The reduction of airway smooth muscle by bronchial thermoplasty stands the test of time. ERJ Open Research. DOI
- Martin Klein, Eleonore Dijoux, Marie-Aude Cheminant, Laurent Intes, Grégory Bouchaud. (2023). GliSODin® prevents airway inflammation by inhibiting T-cell differentiation and activation in a mouse model of asthma. Frontiers in Allergy. DOI
- Eléonore Dijoux, Martin Klein, Barbara Misme-Aucouturier, Marie-Aude Cheminant, Marion de Carvalho, Louise Collin, Dorian Hassoun, Erwan Delage, Mathilde Gourdel, Gervaise Loirand, Vincent Sauzeau, Antoine Magnan, Grégory Bouchaud. (2023). Allergic Sensitization Driving Immune Phenotyping and Disease Severity in a Mouse Model of Asthma. Allergy, Asthma & Immunology Research. DOI
- Misme-Aucouturier B, De Carvalho M, Delage E, Dijoux E, Klein M, Brosseau C, Bodinier M, Guzylack-Piriou L, Bouchaud G. (2022). Oral exposure to bisphenol A exacerbates allergic inflammation in a mouse model of food allergy. Toxicology. DOI
- Martin Klein, Barbara Misme-Aucouturier, Marie-Aude Cheminant, Marion De Carvalho, Marie Wauters, Olivier Tranquet, Antoine Magnan, Grégory Bouchuad. (2021). Engineering a safe monoclonal anti‐human IL‐2 that is effective in a murine model of food allergy and asthma. Allergy. DOI
- (2021). Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling. Thorax. DOI
- (2020). Der p 2.1 Peptide Abrogates House Dust Mites-Induced Asthma Features in Mice and Humanized Mice by Inhibiting DC-Mediated T Cell Polarization. Frontiers in Immunology. DOI
- Moui A, Klein M, Hassoun D, Dijoux E, Cheminant MA, Magnan A, Bouchaud G. (2020). The IL-15 / sIL-15Rα complex modulates immunity without effect on asthma features in mouse. Respiratory research. DOI
- Klein M, Magnan A, Bouchaud G. (2019). [Allergen-derived peptide: A promising approach in asthma]. Revue des maladies respiratoires. DOI
- (2019). Nouveaux acteurs dans la physiopathologie de l’asthme. La Presse Médicale. DOI
- Brosseau C, Durand M, Colas L, Durand E, Foureau A, Cheminant MA, Bouchaud G, Castan L, Klein M, Magnan A, Brouard S. (2018). CD9+ Regulatory B Cells Induce T Cell Apoptosis via IL-10 and Are Reduced in Severe Asthmatic Patients. Frontiers in immunology. DOI
- Rosa N, Triffaux E, Robert V, Mars M, Klein M, Bouchaud G, Canivet A, Magnan A, Guéry JC, Pelletier L, Savignac M. (2017). The β and α2δ auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for TH2 lymphocyte function and acute allergic airway inflammation. The Journal of allergy and clinical immunology. DOI
