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Louis-Philippe Picard

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie

Présentation

Sujet de recherche

Cell Signaling

Disciplines de recherche

Biochemistry, Pharmacology, Molecular Biology

Mots-clés

G proteins, G Protein Coupled Receptor (GPCR), Nuclear Magnetic Resonance (NMR), Signal Transduction, Cell Signaling, Biochemistry, Membrane Proteins

Centre de recherche

Institute for Research in Immunology and Cancer (IRIC)

Langues parlées et écrites

Anglais, Français

Diplômes

(2019). Déterminants structuraux et moléculaires de la sélectivité fonctionnelle des récepteurs couplés aux protéines G. (Doctorate, Ph.D in Biochemistry). Université de Montréal.

(2015). (Bachelor's, Biochemistry and molecular medicine). Université de Montréal.

Expérience académique

Assistant Professor. (2025-). Université de Sherbrooke. Canada.

Post-doctoral fellow. (2019-2024). University of Toronto at Mississauga. Canada.

Publications

Articles de revue

  • Picard,LP; Orazietti, A; Tran, DP; Tucs, A; Hagimoto, S; Qi, Z; Huang, SK; Tsuda, K; Kitao, A; Sljoka, A; Prosser, RS. (2025). Balancing G protein Selectivity and Efficacy in the adenosine A2Areceptor. Nature Chemical Biology 21 71–79. (Published).
  • Picard LP, Pichugin D, Huang SK, Suleiman M, Prosser RS. (2025). Reducing experimental time through spin-lattice relaxation enhancement via dissolved oxygen. Journal of Biomolecular NMR 80 -. (Published).
  • De Bortoli Teixeira, L; Blouin, MJ; Le Gouill, C; Picad, LP; Costa-Neto, C; Bouvier, M; Parreiras e Silva, L. (2025). Sustained Gαs signaling mediated by vasopressin type2 receptors is ligand dependent but endocytosis andβ- arrestin independent. Science Signaling 18 (874), -. (Published).
  • Huang, SK; Picard, LP; Rahmatullah, R; Pandey, A; Van Eps, N; Sunahara, R; Ernst, O; Sljoka, A; Prosser, RS. (2023). Mapping the conformational landscape of the stimulatory heterotrimeric G protein. Nature Structural and Molecular Biology 30 (4), 502–511. (Published).
  • Huang, SK; Almurad, O; Pejana, RJ; Morrison, ZA ; Pandey, A, Picard, LP; Nitz, M; Sljoka, A; Prosser, RS. (2022). Allosteric modulation of the adenosine A2A receptor by cholesterol. Elife 11:e73901. 1-24. (Published).
  • Picard, LP; Prosser, RS. (2021). Advance in the study of GPCRs by 19F NMR. Current Opinion in Structural Biology 69 169-176. (Published).
  • Overduin, M; Trieber, C; Prosser, RS; Picard, LP; Sheff, JG. (2021). Structure and dynamics of native-state transmembrane protein targets and bound lipids. Membranes 11 (6), 451. (Published).
  • Kobayashi, H; Picard, LP; Schonegge, AM; Bouvier, M. (2019). Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells. Nature Protocols 14 (4), 1084-1107. (Published).
  • Stanek, M; Picard, LP; Schmidt, M; Kaindl, J; Hubner, H; Bouvier, M; Weikert, D; Gmeiner, P. (2019). Hybridization of β-adrenergic agonists and antagonists confers G protein bias. Journal of Medicinal Chemistry 62 (10), 5111-5131. (Published).
  • Picard, LP; Schoenegge, AM; Bouvier, M. (2019). Structural Insight into G Protein-Coupled Receptor Signaling Efficacy and Bias between Gs and β-Arrestin. ACS Pharmacology and Translational Science 2 (3), 148-154. (Published).
  • Picard, LP; Schönegge, AM; Lohse, MJ ; Bouvier, M. (2018). Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Communications Biology 1 (1), 106. (Published).
  • Masureel, M; Zou, Y; Picard, LP; van der Westhuizen, E; Mahoney, J; Rodrigues, J; Mildorf, T; Dror, R; Shaw, D; Bouvier, M; Pardon, E; Steyaert, J; Sunahara, R; William, I; Weis, W; Zhang, C; Kobilka, B. (2018). Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist. Nature Chemical Biology 14 (11), 1059-1066. (Published).
  • Schönegge AM*; Gallion J*; Picard LP*; Wilkins AD*; Le Gouill C; Audet M*; Stallaert W*; Lohse MJ; Lichtarge O; Bouvier M. (2017). Evolutionary Action and structural basis of the allosteric switch determinants of B2AR signaling bias. Nature Communication 8 (1), 2169. (Published).
  • Jananji S; Risi C*; Lindamulage IKS*; Picard LP*;Van Sciver R*; Laflamme G*; Albaghjati A*; Hickson GRX; Kwok BH; Galkin VE. (2017). Multimodal and polymorphic interactions between anillin and actin: their implications for cytokinesis. Journal of Molecular Biology 429 (5), 715–731. (Published).

Articles de conférence

  • Picard, LP; Orazietti, A; Tran, DP; Tucs, A; Hagimoto, S; Qi, Z; Huang, SK; Tsuda, K; Kitao, A; Sljoka, A; Prosser, RS. (2023). Balancing G Protein Selectivity and Efficacy in the adenosine A2Areceptor. 22nd GPCR Great Lakes conference. (Published).
  • Picard, LP; Orazietti, A; Tran, DP; Tucs, A; Hagimoto, S; Qi, Z; Huang, SK; Tsuda, K; Kitao, A; Sljoka, A; Prosser, RS. (2023). Balancing promiscuity and selectivity: Determining factors governingG-protein selectivity and efficacy for the adenosine A2A receptor. AUREMN 19th NMR Users Meeting. (Published).
  • Picard, LP; Orazietti,A; Tran, DP; Qi, Z; Kiato, A; Sljoka, A; Prosser, RS. (2022). Determining Factors in G protein selectivity and efficacy for the Adenosine A2a receptor. 21st GPCR Great Lakes Conference. (Published).
  • Picard LP*, Schönegge AM*, Lohse MJ, Bouvier M. (2017). New BRET biosensor to monitor Beta 2Adrenergic Receptor conformation changes from the inside of the cell. 7th IRIC`s Scientific Day. (Published).
  • Picard LP*, Schönegge AM*, Gallion J* , Lichtarge O, Bouvier M. (2017). The link between the PIF and NPxxY motifare responsible for the transduction of signal leading to ?arrestin recruitment to the ?2 adrenergic receptor. 18th GPCR Great Lakes Conference. (Accepted).
  • Picard LP*, Schönegge AM*, Gallion J* , Lichtarge O, Bouvier M. (2017). The link between the PIF and NPxxY motif are responsible for the transduction of signal leading to ?arrestin recruitment to the ?2 adrenergic receptor.GPCR. GPCR workshop 2017. (Published).
  • Picard LP*, Schönegge AM*, Lohse MJ, Bouvier M. (2016). New BRET biosensor to monitor Beta 2 Adrenergic Receptor conformation changes from the inside of the cell. 17th GPCR Great Lakes Conference. (Published).
  • Picard LP*, Jananji S, Hickson G, Galkin V. (2014). Mapping anillin-actin interactions. Biophycal Society, (Published).
  • Picard LP*, Jananji S, Galkin V, Hickson G. (2014). [Determination of binding modes between actin and anillin , essential protein for cell division]. Ste-Justine Hospital, (Published).
  • Picard LP*, Jananji S, Galkin V, Hickson G. (2013). Mapping anillin-actin interactions. Montreal Cell cycle and Cytoskeleton Meeting. (Published).
  • Picard LP*,Jananji S, Hickson G, Galkin V. (2013). Mapping anillin-actin interactions. American Society for Cell Biology, (Published).

Autres contributions

Présentations

  • (2024). Au-delà des structures : Exploration de la dynamique conformationnelle dans la pharmacologie des RCPGs via RMN. Seminar, Institut de Pharmacologie de Sherbrooke. Sherbrooke, Canada
  • (2024). Conformational Dynamics Driving G Protein Selectivity in A2A Receptor Signaling. 1st GPCR forum Conference. online, Canada
  • (2023). Balancing G protein Selectivity and Efficacy in the Adenosine A2A receptor. 22nd GPCR Great Lakes conference. MonteBello, Canada
  • (2023). Balancing promiscuity and selectivity: Determining factors governing G-protein selectivity and efficacy for the adenosine A2A receptor. AUREMN 19th NMR users Meeting. Rio De Janeiro, Brazil
  • (2022). Determining Factors in G Protein Selectivity and Efficacy for the Adenosine A2A Receptor. 21st GPCR Great Lakes conference. Niagara on the Lake, Canada
  • (2022). GPCRs and G proteins Signaling. 2022 INSPIRE Scholars Drug Discovery Program. University of Toronto, Canada