Sarret, Philippe

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie

Coordonnées

Courriel


819-821-8000, poste 72554

Diplômes

(2004) Post-doctorat (Postdoctorat). McGill University.

(2000) Doctorat (Ph. D.).

(1996) Equivalent à la maîtrise (D.E.A.). Université de Nice Sophia-Antipolis.

(1994) Equivalent à la maîtrise (Maîtrise). Université de Nice.

(1993) Baccalauréat (Licence). Université de Nice.

(1991) Baccalauréat (DEUG). Université de Nice.

Présentation

Sujets de recherche

Communication neuronale et neurotransmission, Douleur, Récepteurs et transporteurs, Signalisation cellulaire, Signalisation cellulaire et cancer.

Disciplines de recherche

Neurosciences, Pharmacologie.

Mots-clés

biologie moléculaire et cellulaire, douleur, internalisation, microscopie confocale, neuroanatomie, neuropeptides, neurotensine, pharmacologie et toxicologie, RCPG, signalisation.

Intérêts de recherche

Rôle des Récepteurs Couplés aux Protéines-G (RCPG) dans la Douleur

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2019) Chaire de Recherche du Canada, Niveau 1. Instituts de recherche en santé du Canada. (Distinction).
  • (2016) Prix Jean-de-Margerie - Meilleure publication de l'année. Université de Sherbrooke. (Prix / Récompense).
  • (2016) Prix de la recherche et de la création, Meilleure publication de l'année. Université de Sherbrooke. (Prix / Récompense).
  • (2014) Prix Pierre et Danielle Bourgaux - Chercheur de moins de 10 ans de carrière. Université de Sherbrooke. (Honneur).
  • (2013) Chercheur boursier J2. Fonds de recherche du Québec - Santé (FRQS). (Distinction).
  • (2011) Nouveau chercheur. Institut de recherche en santé d'Ottawa. (Distinction).
  • (2010) Prix Jean-de-Margerie - Meilleure publication de l'année. Université de Sherbrooke. (Honneur).
  • (2009) Prix Relève à la recherche médicale - Chercheur de moins de 10 ans de carrière. (Honneur).
  • (2008) Chercheur boursier J 1. Fonds de recherche du Québec - Santé (FRQS). (Distinction).
  • Chargé de recherche classe 2 - position déclinée. (Distinction).
  • Early Career Award. (Honneur).

Publications

Articles de revue

  • Barrière D.A., Noll C., Roussy G., Kirby K.*, Belleville K*, Lizotte F., Kessai A., Tremblay L., Beaudoin J.F., Sarrhini O., Longpré J.M.*, Lecomte R. Carpentier A., Geraldes P. and Sarret P. (2015). Combination ofhigh-fat/high fructose diet and low-dose streptozotocin to modeling long term type-2 diabetes complications. Diabetes, -, -. (Article soumis).
  • Tétreault P., Parent A., Besserer-Offroy É., Murza A., René A., Dubuc I., Beaudet N.*, Leduc R., Marsault E, Martinez J., Cavelier F., Sarret P. (2015). Pain relief devoid of opioid side effects followingcentral action of a new neurotensin analog. British journal of Pharmacology, -, -. (Article soumis).
  • Constanzo J., Masson-Côté, L., Lepage, M. Tremblay L., Sarret, P., Whittingstall, K., Fouquet, J., Geha, S., Paquette B. (2015). Understanding the Continuum of Vascular Disorders inBrain Following Gamma Knife Irradiation in a Pre-Clinical Model. International Journal of Radiation Oncology, -, -. (Article soumis).
  • Murza A., Sainsily X., Coquerel D., Côté J., Marx P., Besserer-Offroy E., Longpré J.M.*, Salvail D., Dumaine R., Leduc. R., Lesur O., Auger-Messier M., Sarret P. and Marsault E. (2015). Discovery and structure-activity relationships of a bioactive fragment of ELABELA/Toddler that provides cardiovascular effects. J. Med Chem., -, -. (Article soumis).
  • Bégin-Lavallée V., Élora Midavaine, Tétreault P., Jacobi A., Rose S.D., Behlke M.A., Beaudet N.*and Sarret P. (2015). Functional inhibition of CCR2 by Dicer-substrate siRNA prevents pain development. Molecular Pain, -, -. (Article soumis).
  • Chagnon F., Coquerel D., Salvail D., Marsault E., Dumaine R., Auger-Messier M., Sarret P., and Lesur O. (2015). Apelin over dobutamine is cardioprotective and life-saving in a rat model of endotoxin-induced myocardial dysfunction. Circulation Research, -, -. (Article soumis).
  • Deslauriers J., Belleville K., Beaudet N., Sarret P. and Grignon S. (2015). A two-hit model of suicide-trait-related behaviors in a context of schizophrenia-like phenotype: distinct effects of lithium chloride and clozapine. Behavioral Brain Research, -, -. (Révisions requises).
  • Gervais J., Otis C., Guillot M., Gervais J.A., Gauvin D., Péthel C., Authier S., Dansereau M.A., Sarret P. and Troncy E. (2015). Concurrent validity of different pain assessment methods in the rat osteoarthritis MIA model. Journal of Pharmacological and Toxicological Methods, -, -. (Révisions requises).
  • Parent A.J., Tétreault P., Roux M., Belleville K.*, Longpré J.M.*, Beaudet N.*, Goffaux P. and Sarret P. (2015). Descending nociceptive inhibition is modulated in a time-dependent and pain-specific manner following a double-hit model of chronic/tonic pain. Eur. J. of Pain, -, -. (Article soumis).
  • Thomas J.B., Giddings, A.M., Olepu S., Wiethe R.W., Warner K.R., Sarret P., Runyon S.P., Gilmour B.P. (2015). Identification of 2-(amino)tricyclo[3.3.1.13,7]decane-2-carboxylic acid (NTRC-844) as a selective antagonist for the Neurotensin receptor type 2. J. Med Chem., -, -. (Article soumis).
  • Souissi H., Fréchette Y., Murza A., Masse M.H., Marsault E., Sarret P., D’Aragon F., Parent A.J., and Sansoucy Y. (2015). Intracuff 160 mg alkalinized lidocaine reduces cough upon emergence from general anesthesia without N2O: a controlled, randomized, double blind clinical trial. Anesthesia & Analgesia, -, -. (Article soumis).
  • Barrière D.A., Dalman R., Bernier M., Etienne M., Chapuis E., Chalus M., Traoré A., Bielicki G., Keller C., Whittingstall K., Sarret P., Mallet. C., Eschalier A. (2015). Periaqueductal grey matter is a key structure in the analgesic effect of acetaminophen. Scientific Reports, -, -. (Révisions requises).
  • Ferland C.E., Parent A.J., Bote S., Saran N., Ingelmo P.M., Marchand S., Sarret P., Ouellet J.A. (2015). Preoperative norepinephrine levels in cerebrospinal fluid and plasma of pediatric patients predict postoperative pain intensity after an orthopedic surgery. Eur. J. of Pain, -, -. (Article soumis).
  • Besserer-Offroy E., Brouillette R., Brumwell A., Murza A., Longpré J.M.*, Marsault E., Leduc. R. and Sarret P. (2015). Signalling signature of neurotensin receptor type 1, NTS1 following activation by neurotensin, neurotensin 8-13 and neuromedin N. Biochemical Pharmacology, -, -. (Article soumis).
  • Fanelli, R., Besserer-Offroy, E., René, A., Côté, J., Tétreault, P., Collerette-Tremblay, J., Longpré, J.M., Leduc, R., Martinez, J., Cavelier, F., Sarret, P. (2015). Synthesis, in vitro and in vivo characterization of (L)-(trimethylsilyl)alanine containing neurotensin analogues. J. Med Chem., -, -. (Article sous presse).
  • Choinière M., Ware, M.A, Pagé G., Lacasse A., Lanctôt H. Altier A., Beaudet N.* Boulanger A., Bourgault P. Cloutier C., Coupal L., De Koninck Y, Dion D., Dolbec D., Germain L., Martin V., Sarret P. Shir Y, Taillefer M.C., Trépanier A., Tousignant B., Truchon R. (2015). The Quebec Pain Registry– Part I: Development and implementation of a registry of patients attending multidisciplinarypain treatment clinics. Pain, -, -. (Article soumis).
  • François Brial, Carine R. Lussier, Karine Belleville, Philippe Sarret, and François Boudreau. (2015). Ghrelin inhibition restores glucose homeostasis in hepatocyte nuclear factor-1alpha (MODY3)- deficient mice. Diabetes, 64(9), 3314-20. (Article publié).
  • Thomas JB, Giddings AM, Olepu S, Wiethe RW, Warner KR, Sarret P, Longpre JM, Runyon SP, Gilmour BP. (2015). The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type2. Bioorg Med Chem Lett., 25(10), 2060-64. (Article publié).
  • Murza A., Besserer-Offroy E., Côté J., Bérubé P., Longpré J.M.*, Dumaine R., Lesur O., Auger-Messier M., Leduc R. Marsault E. and Sarret P. (2015). C-terminal modifications of apelin-13 significantly change ligand binding, receptor signaling and hypotensive action. Journal of Medicinal Chemistry, 58(5), 2431-40. (Article publié).
  • Thomas J.B., Giddings, A.M., Olepu S., Wiethe R.W., Harris D.L., Narayanan S.,Warner K.R., Sarret P., Longpré J.M.*, Runyon S.P., Gilmour B.P. (2015). Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine(NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptortype 2. Bioorg Med Chem Lett., 25(2), 292-96. (Article publié).
  • Parent A.J., Beaudet N.*, Daigle K., Sabbagh R., Sansoucy Y., Marchand S., Goffaux P. Sarret P. (2015). Relationship between blood- and CSF-bound neurotransmitter concentrations and conditioned pain modulation in pain-free and chronic pain subjects. Journal of Pain, 16(5), 436-44. (Article publié).
  • Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP. (2014). Identification of N-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2. Journal of Medicinal Chemistry, 57(17), 7472-77. (Article publié).
  • Thomas JB , Giddings AM , Wiethe RW , Olepu S , Warner KR , Sarret P , Gendron L , Longpre JM , Zhang Y , Runyon SP , Gilmour BP. (2014). Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Non-peptide Neurotensin Receptor Type 2 Compound. Journal of Medicinal Chemistry, 57(12), 5318-32. (Article publié).
  • Deslauriers J , Racine W , Sarret P , Grignon S. (2014). Preventive effect of α-lipoic acid on prepulse inhibition deficits in a juvenile two-hit model of schizophrenia. Neuroscience, 272, 261-270. (Article publié).
  • Murza A , Belleville K , Longpré JM , Sarret P , Marsault E. (2014). Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid. Biopolymers, 101(4), 297-303. (Article accepté).
  • Demeule M, Beaudet N, Régina A, Besserer-Offroy E, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault E, Leduc R, Lachowicz JE, Gonias SL, Castaigne J.P. and Sarret P. (2014). Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. The Journal of Clinical Investigation, 124(3), 1199-1213. (Article publié).
  • Deslauriers J , Desmarais C , Sarret P , Grignon S. (2014). Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of (±)-α-lipoic acid in SH-SY5Y neuroblastoma cells. Journal of Molecular Neuroscience : MN, 52(3), 378-383. (Article publié).
  • Belkouch M , Dansereau MA , Tétreault P , Biet M , Beaudet N , Dumaine R , Chraibi A , Mélik-Parsadaniantz S , Sarret P. (2014). Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation. Journal of Neuroinflammation, 11(1), 45. (Article publié).
  • Beaudet N , Courteau J , Sarret P , Vanasse A. (2013). Improving the selection of true incident cases of low back pain by screening retrospective administrative data. European Journal of Pain (London, England), 18(7), 923-931. (Article publié).
  • *Doré-Savard L , *Barrière DA , *Midavaine E , Bélanger D , *Beaudet N , Tremblay L , Beaudoin JF , Turcotte EE , Lecomte R , Lepage M , Sarret P. (2013). Mammary Cancer Bone Metastasis Follow-up Using Multimodal Small-Animal MR and PET Imaging. Journal of Nuclear Medicine : the official publication, Society of Nuclear Medicine, 54(6), 944-52. (Article publié).
  • *Tétreault P , *Beaudet N , Perron A , *Belleville K , René A , Cavelier F , Martinez J , Stroh T , Jacobi AM , Rose SD , Behlke MA , Sarret P. (2013). Spinal NTS2 receptor activation reverses signs of neuropathic pain. FASEB Journal : the official publication of the Federation of American Societies for Experimental Biology, 27(9), 3741-52. (Article publié).
  • *Deslauriers J , Larouche A , Grignon S, Sarret P. (2013). Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 45C, 156-64. (Article publié).
  • Quaegebeur N , Masson P , *Beaudet N , Sarret P. (2013). Pressure mapping system based on guided waves reflection. The Journal of the Acoustical Society of America, 133(5), 3546. (Article publié).
  • *Deslauriers J , Desmarais C , Sarret P , Grignon S. (2013). α-Lipoic acid interaction with dopamine D2 receptor-dependent activation of the Akt/GSK-3β signaling pathway induced by antipsychotics: potential relevance for the treatment of schizophrenia. Journal of Molecular Neuroscience : MN, 50(1), 134-45. (Article publié).
  • *Doré-Savard L , *Beaudet N , Tremblay L , Xiao Y , Lepage M , Sarret P. (2013). A micro-imaging study linking bone cancer pain with tumor growth and bone resorption in a rat model. Clinical & Experimental Metastasis, 30(2), 225-36. (Article publié).
  • *Beaudet N , Courteau J , Sarret P , Vanasse A. (2013). Prevalence of claims-based recurrent low back pain in a Canadian population: a secondary analysis of an administrative database. BMC Musculoskeletal Disorders, 14(151), 1-8. (Article publié).
  • Girard S , Sébire H , Brochu ME , Briota S , Sarret P , Sébire G. (2012). Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries. Brain, Behavior, and Immunity, 26(8), 1331-39. (Article publié).
  • *Parent AJ , *Beaudet N , Beaudry H , Bergeron J , *Bérubé P , Drolet G , Sarret P , Gendron L. (2012). Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain. Behavioural Brain Research, 229(1), 160-67. (Article publié).
  • Guillemette A , *Dansereau MA , *Beaudet N , Richelson E , Sarret P. (2012). Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain. European Journal of Pain (London, England), 16(4), 473-84. (Article publié).
  • Chen A , Gössling EK , Witkowski L , Bhindi A , Bauch C , *Roussy G , Sarret P , Kreienkamp HJ , Stroh T. (2012). Regional and subcellular distribution of the receptor-targeting protein PIST in the rat central nervous system. The Journal of Comparative Neurology, 520(5), 889-913. (Article publié).
  • *Murza A , *Parent A , *Besserer-Offroy E , Tremblay H , Karadereye F , *Beaudet N , Leduc R , Sarret P , Marsault É. (2012). Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability. ChemMedChem, 7(2), 318-25. (Article publié).
  • *Belkouch M , *Dansereau MA , Réaux-Le Goazigo A , Van Steenwinckel J , *Beaudet N , Chraibi A , Melik-Parsadaniantz S , Sarret P. (2011). The chemokine CCL2 increases Nav1.8 sodium channel activity in primary sensory neurons through a Gβγ-dependent mechanism. The Journal of Neuroscience : the official Journal of the Society for Neuroscience, 31(50), 18381-90. (Article publié).
  • Rostène W , *Dansereau MA , Godefroy D , Van Steenwinckel J , Reaux-Le Goazigo A , Mélik-Parsadaniantz S , Apartis E , Hunot S , *Beaudet N , Sarret P. (2011). Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous system. Journal of Neurochemistry, 118(5), 680-94. (Article publié).
  • *Tétreault P , *Dansereau MA , *Doré-Savard L , *Beaudet N , Sarret P. (2011). Weight bearing evaluation in inflammatory, neuropathic and cancer chronic pain in freely moving rats. Physiology & Behavior, 104(3), 495-502. (Article publié).
  • Maloum F , Allaire JM , Gagné-Sansfaçon J , Roy E , *Belleville K , Sarret P , Morisset J , Carrier JC , Mishina Y , Kaestner KH , Perreault N. (2011). Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells. American Journal of Physiology. Gastrointestinal and Liver Physiology, 300(6), G1065-79. (Article publié).
  • Otis V , Sarret P , Gendron L. (2011). Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience, 183, 221-29. (Article publié).
  • *Deslauriers J , Lefrançois M , Larouche A , Sarret P , Grignon S. (2011). Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y neuroblastoma cells. Synapse (New York, N.Y.), 65(4), 321-31. (Article publié).
  • Van Steenwinckel J , Reaux-Le Goazigo A , Pommier B , Mauborgne A , *Dansereau MA , Kitabgi P , Sarret P , Pohl M , Mélik Parsadaniantz S. (2011). CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury. The Journal of Neuroscience : the official Journal of the Society for Neuroscience, 31(15), 5865-75. (Article publié).
  • *Doré-Savard L., Tremblay L., *Belleville K., *Beaudet N., Lecomte R., Lepage M. and Sarret P. (2011). Approche d'imagerie médicale multimodale dans l'étude de la douleur cancéreuse. Douleur et Analgésie, 24(2), S4-6. (Article publié).
  • *Benoit CE , Rowe WB , Menard C , Sarret P , Quirion R. (2011). Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory. Trends in Pharmacological Sciences, 32(1), 43-52. (Article publié).
  • *Tétreault P., *Beaudet N. and Sarret P. (2011). L'interférence de l'ARN: une nouvelle approche pour traiter la douleur. 24 (2), S35-37. Douleur et Analgésie, 24(2), S35-37. (Article publié).
  • *Doré-Savard L , Otis V , *Belleville K , Lemire M , Archambault M , Tremblay L , Beaudoin JF , *Beaudet N , Lecomte R , Lepage M , Gendron L , Sarret P. (2010). Behavioral, medical imaging and histopathological features of a new rat model of bone cancer pain. PloS ONE, 5(10), e13774. (Article publié).
  • Sarret P , *Doré-Savard L , *Beaudet N. (2010). Direct application of siRNA for in vivo pain research. Methods in Molecular Biology (Clifton, N.J.), 623, 383-95. (Article publié).
  • Hwang JR , Baek MW , Sim J , Choi HS , Han JM , Kim YL , Hwang JI , Kwon HB , *Beaudet N , Sarret P , Seong JY. (2010). Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors. Biochemical and Biophysical Research Communications, 391(1), 1007-13. (Article publié).
  • *Lafrance M , *Roussy G , *Belleville K , Maeno H , *Beaudet N , Wada K , Sarret P. (2010). Involvement of NTS2 receptors in stress-induced analgesia. Neuroscience, 166(2), 639-52. (Article publié).
  • *Roussy G , Beaudry H , *Lafrance M , *Belleville K , *Beaudet N , Wada K , Gendron L , Sarret P. (2010). Altered morphine-induced analgesia in neurotensin type 1 receptor null mice. Neuroscience, 170(4), 1286-94. (Article publié).
  • *Benoit CE , Bastianetto S , Brouillette J , Tse Y , Boutin JA , Delagrange P , Wong T , Sarret P , Quirion R. (2010). Loss of quinone reductase 2 function selectively facilitates learning behaviors. The Journal of Neuroscience : the official journal of the Society for Neuroscience, 30(38), 12690-700. (Article publié).
  • *Roussy J.F., Chagnon F., Gallo-Payet N., Dumaine R., Sarret P., Chraibi A., Chouinard L., Hogue B. and Lesur O. (2010). Proven infection-related sepsis induces a differential stress response early after ICU admission. Crit. Care, 14(4), R131. (Article publié).
  • Chamberland C , Barajas-Martinez H , Haufe V , Fecteau MH , Delabre JF , Burashnikov A , Antzelevitch C , Lesur O , Chraibi A , Sarret P , Dumaine R. (2010). Modulation of canine cardiac sodium current by Apelin. Journal of Molecular and Cellular Cardiology, 48(4), 694-701. (Article publié).
  • *Doré-Savard L., Tremblay L., *Belleville K., Archambault M., Beaudoin J.F., *Beaudet N., Lecomte R., Sarret P. and Lepage M. (2009). Tumor Growth Characterization in a Rat Bone Cancer Pain Model Using MRI-PET Coregistration. Mol Imaging Bio, 12, 408. (Article publié).
  • Girard S , Kadhim H , *Beaudet N , Sarret P , Sébire G. (2009). Developmental motor deficits induced by combined fetal exposure to lipopolysaccharide and early neonatal hypoxia/ischemia: a novel animal model for cerebral palsy in very premature infants. Neuroscience, 158(2), 673-82. (Article publié).
  • *Roussy G , *Dansereau MA , Baudisson S , Ezzoubaa F , *Belleville K , *Beaudet N , Martinez J , Richelson E , Sarret P. (2009). Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity. Molecular Pain, 5, 38. (Article publié).
  • *Dansereau MA , Gosselin RD , Pohl M , Pommier B , Mechighel P , Mauborgne A , Rostene W , Kitabgi P , *Beaudet N , Melik-Parsadaniantz S, Sarret P. (2008). Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Journal of Neurochemistry, 106(2), 757-69. (Article publié).
  • *Roussy G , *Dansereau MA , *Doré-Savard L , *Belleville K , *Beaudet N , Richelson E , Sarret P. (2008). Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model. Journal of Neurochemistry, 105(4), 1100-14. (Article publié).
  • Gosselin RD , *Dansereau MA , Pohl M , Kitabgi P , *Beaudet N , Sarret P , Mélik Parsadaniantz S. (2008). Chemokine network in the nervous system: a new target for pain relief. Current Medicinal Chemistry, 15(27), 2866-75. (Article publié).
  • Larouche A , *Berube P , Sarret P , Grignon S. (2008). Subacute H2O2, but not poly(IC), upregulates dopamine D2 receptors in retinoic acid differentiated SH-SY5Y neuroblastoma. Synapse (New York, N.Y.), 62(1), 70-73. (Article publié).
  • Sharif N , Gendron L , Wowchuk J , Sarret P , Mazella J , *Beaudet A , Stroh T. (2007). Coexpression of somatostatin receptor subtype 5 affects internalization and trafficking of somatostatin receptor subtype 2. Endocrinology, 148(5), 2095-2105. (Article publié).
  • Perron A , Sharif N , Sarret P , Stroh T , *Beaudet A. (2007). NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization. Biochemical and Biophysical Research Communications, 353(3), 582-90. (Article publié).
  • Sarret P , *Beaudet N , *Roussy G. (2007). NTS2 receptor: slamming the brakes on pain. Médecine sciences : M/S, 23(1), 11-12. (Article publié).
  • Stroh T , Sarret P , Tannenbaum GS , *Beaudet A. (2006). Immunohistochemical distribution and subcellular localization of the somatostatin receptor subtype 1 (sst1) in the rat hypothalamus. Neurochemical Research, 31(2), 247-57. (Article publié).
  • Sarret P., Esdaile M.J., Perron A., Stroh T., Martinez J. and Beaudet A. (2005). Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors. The Journal of Neuroscience : the official Journal of the Society for Neuroscience, 25(36), 8188-96. (Article publié).
  • Perron A , Sarret P , Gendron L , Stroh T , Beaudet A. (2005). Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system. The Journal of biological chemistry, 280(11), 10219-27. (Article publié).
  • Gendron L , Perron A , Payet MD , Gallo-Payet N , Sarret P , Beaudet A. (2004). Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2. Molecular pharmacology, 66(6), 1421-30. (Article publié).
  • Sarret P , Esdaile MJ , McPherson PS , Schonbrunn A , Kreienkamp HJ , Beaudet A. (2004). Role of amphiphysin II in somatostatin receptor trafficking in neuroendocrine cells. The Journal of biological chemistry, 279(9), 8029-37. (Article publié).
  • Sarret P , Krzywkowski P , Segal L , Nielsen MS , Petersen CM , Mazella J , Stroh T , Beaudet A. (2003). Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system. The Journal of comparative neurology, 461(4), 483-505. (Article publié).
  • Sarret P , Perron A , Stroh T , Beaudet A. (2003). Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system. The Journal of comparative neurology, 461(4), 520-38. (Article publié).
  • Sarret P , Gendron L , Kilian P , Nguyen HM , Gallo-Payet N , Payet MD , Beaudet A. (2002). Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells. The Journal of biological chemistry, 277(39), 36233-43. (Article publié).
  • Dal Farra C , Sarret P , Navarro V , Botto JM , Mazella J , Vincent JP. (2001). Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines. International journal of cancer. Journal international du cancer, 92(4), 503-9. (Article publié).
  • Navarro V , Martin S , Sarret P , Nielsen MS , Petersen CM , Vincent J , Mazella J. (2001). Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin. FEBS letters, 495(1-2), 100-5. (Article publié).
  • Boudin H , Sarret P , Mazella J , Schonbrunn A , Beaudet A. (2000). Somatostatin-induced regulation of SST(2A) receptor expression and cellsurface availability in central neurons: role of receptor internalization. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(16), 5932-9. (Article publié).
  • Stroh T , Jackson AC , Sarret P , Dal Farra C , Vincent JP , Kreienkamp HJ , Mazella J , Beaudet A. (2000). Intracellular dynamics of sst5 receptors in transfected COS-7 cells: maintenance of cell surface receptors during ligand-induced endocytosis. Endocrinology, 141(1), 354-65. (Article publié).
  • Sarret P , Nouel D , Dal Farra C , Vincent JP , Beaudet A , Mazella J. (1999). Receptor-mediated internalization is critical for the inhibition of the expression of growth hormone by somatostatin in the pituitary cell line AtT-20. The Journal of biological chemistry, 274(27), 19294-300. (Article publié).
  • cDubuc I , Sarret P , Labbé-Jullié C , Botto JM , Honoré E , Bourdel E , Martinez J , Costentin J , Vincent JP , Kitabgi P , Mazella J. (1999). Identification of the receptor subtype involved in the analgesic effect of neurotensin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(1), 503-10. (Article publié).
  • Nouel D , Sarret P , Vincent JP , Mazella J , Beaudet A. (1999). Pharmacological, molecular and functional characterization of glial neurotensin receptors. Neuroscience, 94(4), 1189-97. (Article publié).
  • Sarret P , Botto JM , Vincent JP , Mazella J , Beaudet A. (1998). Preferential expression of sst2A over sst2B somatostatin receptor splice variant in rat brain and pituitary. Neuroendocrinology, 68(1), 37-43. (Article publié).
  • Sarret P , Beaudet A , Vincent JP , Mazella J. (1998). Regional and cellular distribution of low affinity neurotensin receptor mRNA in adult and developing mouse brain. The Journal of comparative neurology, 394(3), 344-56. (Article publié).
  • Botto JM , Chabry J , Sarret P , Vincent JP , Mazella J. (1998). Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism. Biochemical and biophysical research communications, 243(2), 585-90. (Article publié).
  • Botto JM , Sarret P , Vincent JP , Mazella J. (1997). Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system. FEBS letters, 400(2), 211-4. (Article publié).
  • Mazella J , Botto JM , Guillemare E , Coppola T , Sarret P , Vincent JP. (1996). Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 16(18), 5613-20. (Article publié).

Chapitres de livre

  • Deslauriers J., Sarret P. and Grignon S. (2015). The impact of oxidative stress on the dopaminergic neurotransmission. Oxidative and nitrative stress in psychiatric disorders. (Springer-Verlag). S. Grigon & A. Dietrich-Muszalska. (Article sous presse).
  • Doré-Savard, L., Beaudet, N. and Sarret, P. (2015). Chapter in Landmark Papers in Pain. Neuromethods (Oxford University Press). Wolfgang Walz and Craig W. Stevens. (Article publié).
  • L. Doré-Savard*, L. Tremblay*, K. Belleville*, N. Beaudet*, R. Lecompte, M. Lepage and P. Sarret*. (2011). Approche d'imagerie médicale multimodale dansl'étude de la douleur cancéreuse. Douleur et analgésie (24, 2, S4-6). Springer Verlag. (Article publié).
  • Tétreault, P.*, Beaudet N.* and Sarret P.*. (2011). L'interférence de l'ARN: une nouvelle approche pour traiter la douleur. Douleur et analgésie (24, 2, S35-37). Springer Verlag. (Article publié).
  • Sarret P., *Doré-Savard L., *Tétreault P., *Dansereau M.A., *Bégin-Lavallée V. and *Beaudet N. (2011). Using RNA interference to down-regulate GPCRs. G-Protein-Coupled Receptor Technology (60, 379-402). Springer-Verlag (Humana Press). (Article publié).
  • Sarret P., *Doré-Savard L., *Tétreault P., *Bégin-Lavallée V. and *Beaudet N. (2010). Application of dicer-substrate siRNA in pain research. Book chapter in RNA. Technologies and Their Applications (XVI, 161-191). Springer-Verlag. (Article publié).
  • Melik-Parsadaniantz S., Sarret P. and Rostène W. (2010). Chemokine and chemokine receptors in the brain. Chemokines Receptors Function and NeuroAids (XVI, 173-191). Springer-Verlag. (Article publié).
  • Sarret P, *Doré-Savard L, *Beaudet N. (2010). Direct application of siRNA for in vivo pain research. Methods Molecular Biology (623, 383-395). Springer. (Article publié).

Articles de conférence

  • Marsault, E., Murza, A., Besserer-Offroy, É., Côté, J., Longpré. J.M. and Sarret, P. (2015). Modulating the apelin receptor signaling with macrocyles. Pacificem. (Article accepté).
  • Côté J., Demeule M., Beaudet N.*, Regina A., Belleville K.*, Larocque A., Longpré J.M.*, Lachowicz J., Castaigne J.P. and Sarret P. (2015). Creation of a new brain-penetrant peptide-neurotensin(8-13) conjugate exerting analgesic activities after systemic administration. 45TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Besserer-Offroy É., Lafrance M., Ouirzane M., Murza A., Longpré J.M., Marsault E., Leduc R., Sarret P. (2015). Design, synthesis and exploration of structure-function relationship studies of new macrocyclic dérivatives of apelin-13. 45TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Monpays C., Deslauriers J., Sarret P. and Grignon S. (2015). Determination of mitochondrial activity in a mice juvenile two-hit model of schizophrenia. 45TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Dansereau M.A., Jacobi A.M., Rose S.C. Behlke M.A., Longpré J.M.* and Sarret P. (2015). Interfering with chronic inflammatory pain: the case of Dicer-substrate siRNAs targeting the CCL2/CCR2 chemokine system. 45TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Girard R., Maurice-Gelinas C., Faye C., Pare G., Monpays C., Deslauriers J., Sarret P. and Grignon S. (2015). Lack of preventive effect of acute DHA and subacute EPA/DHA combination on PPI disruption in a murine juvenile two-hit model of schizophrenia. 45TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Constanzo J., Descoteaux M., Lepage M., Tremblay L., Dumont M., Longpré J.M., Kirby K., Geha L., Masson-Coté L., Sarret P. and Paquette B. (2015). Neuroplasticity changes in rat brain following targeted gamma knife irradiation. 45TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Midavaine E., Longpré J.M. * and Sarret P. (2015). Selective CCR2 chemokine receptor antagonists as potentiel treatment of bone cancer pain. 45TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Vivancos M., Besserer-Offroy É., Brouillette R., René A., Fanelli R., Lafrance M., Tétreault P., Colerette-Tremblay J., Longpré J.M.*, Martinez J., Cavelier F. and Sarret P. (2015). Site-selective modifications of the neurotensin hexapeptide fragment lead to the generation of highly active and metabolically stable NT(8-13) analogs. 45TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Constanzo J., Lepage M., Tremblay L., Descoteaux M., Kirby K., Masson-Coté L., Sarret P. and Paquette B. (2015). Neurovascular coupling assessment in rat brain following targeted gamma knife irradiation. 61ST Annual Meeting-Radiation Research Society. (Article accepté).
  • Buckley S.M., Unsain N., Osso L., Midavaine E., Belleville K., Barriere D., Longpre J.M., Mogil J.S., Sarret P., Seguela P. and Barker P. (2015). p75NTR deletion enhances chronic one cancer pain but does not alter acute pain responses. Neurotrophic Factors Gordon Research Conference. (Article accepté).
  • Rémond E., Hapău D., René A., Martinez J., Sarret P, Zaharia V., Cavelier F. (2015). Synthèse diastéréosélective de dérivés thiazoles α-aminoacideset applications pour la synthèse de nouveaux analogues de la neurotensine. 19ième Congrès du Groupe Français des Peptides et des Protéines. (Article accepté).
  • Darbaky Y., Chirat C., Maffre V., Duval A., Gobron S., Miolt-Noirault E., Miladi I., Barrière D., Midavaine E., Sarret P. and Diop L. (2014). Cancer-induced bone pain in rat : Cellular, behavioral, pharmacological and medical imaging characterization. 44TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Buckley S.M., Osso L., Belleville K.*, Barrière D., Longpré J.M.*, Mogil J.S., Sarret P., Seguela P. and Barker P. (2014). Investigating the role of p75NTR in nociception using conditional knockout mice. 44TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Deslauriers J., Sarret P. and Grignon S. (2014). Potential implication of the kynurenine pathway in a juvenile two-hit animal model of schizophrenia: Reversal of PPI deficits by the inhibition of indoleamine 2,3-dioxygenase. 44TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Monpays C., Tremey A., Deslauriers J., Racine W., Asli K., Sarret P. and Grignon S. (2014). Sleep deprivation at juvenile age causes alterations in cortical GAD67 levels in juvenile mice and induces prepulse inhibition deficit in adult female mice. 44TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Lafrance, M., René A., Beaudet, N., Lonpré J.M., Cavelier F., Martinez J. and Sarret, P. (2014). Activation of NTS2 receptors in the rostral ventromedial medulla induces analgesia through serotoninergic-mediated descending inhibition in a rat model of tonic pain. 15th World Congress on Pain. (Article accepté).
  • Tétreault P., Besserer-Offroy É., Murza A., Parent A., Bérubé P., René A., Dubuc I., Longpré J.M.*, Beaudet N.*, Leduc R., Marsault É., Martinez J., Cavelier F. and Sarret P. (2014). Analgesic potency of a new neurotensin analog in different experimental pain models. 15Th Great Lakes GPCR Retreat. (Article accepté).
  • Tétreault P., Besserer-Offroy É., Murza A., Parent A., Bérubé P., René A., Dubuc I., Longpré J.M.*, Beaudet N.*, Leduc R., Marsault É., Martinez J., Cavelier F. and Sarret P. (2014). Analgesic potency of a new neurotensin analog in different experimental pain models. 15Th Great Lakes GPCR Retreat. (Article accepté).
  • Besserer-Offroy É., Murza A., Bérubé P., Dinh T., Longpré J.M.*, Leduc R., Marsault É. and Sarret P. (2014). C-terminal modifications of Apelin-13: generation of new biased analogs and impact on hypotensive effect. 15Th Great Lakes GPCR Retreat. (Article accepté).
  • Darbaky, Y., Chirat, C., Maffre, V., Duval, A., Gobron, S., Miolt-Noirault, E., Miladi, I., Barrière D., Midavaine, E., Sarret, P. and Diop, L. (2014). Characterization of a rat model of cancer-induced bone pain using cellular, behavioral, pharmacological and medical imaging methods. 15th World Congress on Pain. (Article accepté).
  • Murza A., Besserer-Offroy É., Bérubé P., Longpré J.M.*, Sarret P. and Marsault E. (2014). Design, synthesis and exploration of structure-function relationship studies of new macrocyclic derivatives of apelin-13. 15Th Great Lakes GPCR Retreat. (Article accepté).
  • Besserer-Offroy É., Brumwell A., Murza A., Longpré J.M.*, Sarret P. and Leduc R. (2014). Establishing the signaling signature of hNTS1 by Neurotensin, Neurotensin 8-13 or Neuromedin N. 15Th Great Lakes GPCR Retreat. (Article accepté).
  • Roux M., Tétreault P., Longpré J.M.*, Jacobi A.M., Rose S.C. Behlke M.A. and Sarret P. (2014). Novel antisense technology-based drugs for the targeted treatment of pain: Proof-of-concept with the NTS2 receptor in a context of acute and persistent pain. 15Th Great Lakes GPCR Retreat. (Article accepté).
  • Midavaine É., Tétreault P., Barrière D., Longpré J.M. and Sarret P. (2014). Targeting CCL2/CCR2 signaling in the management of metastatic bone pain. 15Th Great Lakes GPCR Retreat. (Article accepté).
  • Midavaine, E., Tétreault, P., Barrière D., Longpré, J.M. and Sarret, P. (2014). Targeting CCL2/CCR2 signaling in the management of metastatic bone pain. 15th World Congress on Pain. (Article accepté).
  • Marsault, E., Murza, A., Besserer-Offroy, E., Bérubé, P., Longpré, J.M. and Sarret, P. (2014). Deciphering the structure function of apelin with unnatural amino acids and macrocycles. 33rd European Peptide Symposium. (Article accepté).
  • Murza, A., Besserer-Offroy, E., Bérubé, P., Parent, A., Longpré, J.M., Leduc, R., Sarret, P. and Marsault E. (2014). Design, synthesis and structure-activity relationship studies of new macrocyclic analogs of apelin-13. 97th Canadian Chemistry Conference and Exhibition. (Article accepté).
  • Beaudet, N., Courteau, J., Michaud, F., Sarret, P., Vanasse A. (2014). Epidemiology of claims-bsed recurrent low back pain in Canada using secondary analyses of administrative data. Australian Pain Society's 34th Annual Scientific Meeting (ASM). (Article accepté).
  • *Murza A., *Besserer-Offroy E., *Lafrance M., Roux M., *Beaudet N., *Longpré J.M., Leduc R., Marsault E. and Sarret P. (2013). Chronic neuropathic pain evokes adaptive changes in the response to endogenous pain inhibition in rats. 43TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Parent A., *Tétreault P., Roux M., *Belleville K., Aurais-Blais C., Goffaux P. and Sarret P. (2013). Chronic neuropathic pain evokes adaptive changes in the response to endogenous pain inhibition in rats. 43TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Besserer-Offroy E., *Tétreault P., *Lafrance M., *Murza A., René A., *Longpré J.M., Cavelier F., Matinez J., Marsault E., Leduc R. and Sarret P. (2013). Deciphering the NTS1 receptor signalling pathways leading to analgesia and hypothermia. 43TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Monpays C., Tremey A., *Deslauriers J., Racine W., Asli K., Sarret P. and Grignon S. (2013). Development of manic symptoms by sleep deprivation at juvenile age. 43TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Deslauriers J., *Belleville K., *Beaudet N., Sarret P. and Grignon S. (2013). Distinct effects of lithium chloride and clozapine in preventing suicide-related behaviors in a two-hit model of schizophrenia. 43TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Bergeron J., Allard M.J., *Deslauriers J., Sarret P. and Grignon S., Fortier L.C., Poyart C., Sébire G. (2013). Group B streptococcus inflammatory response induced during gestation leads to perinatal injuries and subsequent behavioral impairments in male offspring mimicking autistic features. 43TH Annual Meeting-Society for eurosciences. (Article accepté).
  • *Midavaine É., *Barrière D., *Tétreault P., *Longpré J.M. and Sarret P. (2013). Pharmacological inhibition of the CCL2/CCR2 chemokinergic system reduces cancer-related pain behaviors. 43TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Lafrance M., *Murza A., *Besserer-Offroy E., *Longpré J.M., Leduc R., Stroh T., Marsault E., Sarret P. (2013). Impact of the incorporation of unnatural amino acids at the C-terminal end of the apelin peptide on pain inhibition. 8Th EFIC – Pain in Europe Congress. (Article accepté).
  • *Beaudet N., Courteau J., Sarret P, Vanasse A. (2013). Improving the selection of true incident cases of low back pain by screening retrospective administration data. 8Th EFIC – Pain in Europe Congress. (Article accepté).
  • *Belkouch M., *Dansereau M.A., *Beaudet N., Chraibi A., Pohl M., Melik-Parsadaniantz S. and Sarret P. (2013). Increase Nav1.8 current in large-diameter sensory neurons following chronic inflammatory pain. 20TH Colloque des Canaux ioniques. (Article accepté).
  • *Parent A., *Tétreault P., Roux M., *Belleville K., Aurais-Blais C., Sabbagh R., Sansoucy Y., Sarret P. and Goffaux P. (2013). Épuisement des mécanismes endogènes d’inhibition de la douleur chez les patients souffrant de douleur chronique: l’hypothèse des cliniciens était bonne depuis le début. 55ème réunion annuelle du Club de Recherches Cliniques du Québec. (Article accepté).
  • *Tétreault P., *Parent A., *Besserer-Offroy E., *Murza A., René A., Dubuc I., *Beaudet N., Leduc R., Marsault E., Martinez J. Cavelier F. and Sarret P. (2013). Pain relief devoid of opioid side effects following central action of a new neurotensin analog. 14TH World Congress on Pain. (Article accepté).
  • *Parent A., *Beaudet N., Gagnon R., Fortin M., Bherer P., Daigle K., Sabbagh R, Sansoucy Y., Aurais-Blais C., Goffaux P. and Sarret P. (2013). Quantification of neuropeptides in rodent and human cerebrospinal fluid: Use of mass spectrometry to identify biomarkers in pain research. 14TH World Congress on Pain. (Article accepté).
  • *Deslauriers J., *Belleville K., *Beaudet N., Sarret P. and Grignon S. (2013). Distinct effects of lithium chloride and clozapine in preventing suicide-related behaviors in a two-hit model of schizophrenia. IASR World Congress on Suicide. (Article accepté).
  • *Besserer-Offroy E., Demeule M., *Beaudet N., Régina A., *Tétreault P., *Belleville K., Ché C., Larocque A., Lachowicz J., Castaigne J.P., Sarret P. (2013). Use of peptide technology for analgesic brain delivery. 23rd American Peptide Symposium. (Article accepté).
  • *Parent A., *Tétreault P., *Belleville K., Roux M., Goffaux P. and Sarret P. (2013). Endogenous inhibitory responses in rats change when chronic pain sets in: Evidence of initial compensation and subsequent extinction. 4th International Congress on Neuropathic Pain. (Article accepté).
  • *Murza A., *Besserer-Offroy E., *Lafrance M., *Parent A., *Beaudet N., Leduc R., Sarret P. and Marsault E. (2013). Incorporation of unnatural amino acids in apelin: Influence on biased signaling and activity in animal models of pain. 96th Canadian Chemistry Conference and Exhibition. (Article accepté).
  • *Doré-Savard L., *Barrière D., *Midavaine É., Bélanger D., *Beaudet N.*, Tremblay L., Beaudoin J.F, Turcotte E., Lecomte R., Sarret P. and Lepage M. (2013). MRI-PET imaging applied to a novel rat model of bone cancer pain. PSMR 2013 / 4th Jülich MR-PET Workshop. (Article accepté).
  • *Tétreault P., *Beaudet N., Martinez J. Cavelier F., Jacobi A.M., Rose S.D., Behlke M.A. and Sarret P. (2013). Pharmacological activation of NTS2 receptors reduces behavioral hypersensitivity after peripheral nerve injury. 4th International Congress on Neuropathic Pain. (Article accepté).
  • *Deslauriers J., Sarret P. and Grignon S. (2013). Therapeutic potential of -lipoic acid on PPI deficits in a juvenile two-hit animal model of schizophrenia. 14TH International Congress on Schizophrenia Research. (Article accepté).
  • Quaegebeur N., Masson P., Brault L.P., *Beaudet N., Sarret P. (2013). Pressure mapping system based on guided waves reflection. SPIE Smart Structures and Materials & Nondestructive Evaluation and Health Monitoring. (Article accepté).
  • Lachowicz J., Demeule M., Larocque A., Ché C., *Beaudet N., *Belleville K., Castaigne J.P. and Sarret P. (2012). Analgesic properties of a new brain-penetrant Angiopep-2-neurotensin derivative (ANG2002) for treating chronic pain. 42TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • Demeule M., Lachowicz J., Yang Q., Ché C., Otis V., Sarret P., Castaigne J.P. and Gendron L. (2012). A new brain-penetrant Angiopep-2-morphine-6-glucuronide derivative (ANG2010) with pain relieving properties. 42TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Parent A., *Tétreault P., Shooner J., *Beaudet N., Aurais-Blais C., Goffaux P. and Sarret P. (2012). Central and peripheral modulation of serotoninergic activity after DNIC activation in rodent with chronic inflammatory pain. 42TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Barrière D., *Doré-Savard L., Tremblay L., *Beaudet N., Lepage M., Lecomte R. and Sarret P. (2012). Contribution of micro-imaging studies and neurotensinergic agonists in the research for a bone cancer pain treatment. 42TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Lafrance M., René A., *Beaudet N., Martinez J. Cavelier F. and Sarret P. (2012). Descending pain inhibition by brainstem NTS2 receptors. 42TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Lemire M., *Lainé J., *Beaudet N. and Sarret P. (2012). Identification of the secretory protein secretogranin III as an interaction partner of the neurotensin NTS2 receptor. 42TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Tétreault P., *Parent A., *Besserer-Offroy E., *Murza A., René A., Dubuc I., *Beaudet N., Leduc R., Marsault E., Martinez J. Cavelier F. and Sarret P. (2012). Neurotensin receptor-based therapy: Achieving analgesia without opioid-related side effects. 42TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Tétreault P., *Beaudet N., Martinez J. Cavelier F., Rose S.D., Jacobi A.M., Behlke M.A. and Sarret P. (2012). Spinal NTS2 agonists reverses signs of neuropathic pain. 42TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Murza A., *Parent A., *Besserer-Offroy E., Tremblay H., Karadereye F., *Beaudet N., Leduc R., Sarret P. and Marsault E. (2012). Elucidation of the structure-activity relationships of apelin: Influence of unnatural amino acids on binding, signaling and plasma stability. 32nd European Peptide Symposium. (Article accepté).
  • *Lafrance M., *Murza A., *Besserer-Offroy E., Bossé S., *Beaudet N., Leduc R., Stroh T., Marsault E. and Sarret P. (2012). Analgesic effect of apelin and structural analogs on pain modulation. 14TH World Congress on Pain. (Article accepté).
  • *Belkouch M., *Dansereau M.A., *Tétreault P., *Beaudet N., Chraibi A., Melik-Parsadaniantz S. and Sarret P. (2012). Phenotypic switch in A afferent fibers mediates inflammatory pain hypersensitivity. 14TH World Congress on Pain. (Article accepté).
  • *Doré-Savard L., Tremblay L., *Beaudet N., Lepage M. and Sarret P. (2011). A micro-imaging study to correlate bone cancer pain with tumor growth and bone resorption in the rat. 41TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Dansereau M.A., *Murza A., *Beaudet N., Marsault E., Melik-Parsadaniantz S. and Sarret P. (2011). (2011). Chronic inflammatory pain: should we bet on a CCR2 antagonist?. 41TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Tétreault P., *Dansereau M.A., *Doré-Savard L., *Beaudet N. and Sarret P. (2011). Dynamic weight bearing: from characterization to drug screening. 41TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Roussy G., *Belleville K., *Kirby K., *Beaudet N., Wada K., Martinez J. and Sarret P. (2011). Impact of NTS2 receptor activation on bone cancer pain development and pain-related behaviors. 41TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Lafrance M., *Murza A., Bossé S., *Beaudet N., Stroh T., Marsault E. and Sarret P. (2011). Involvement of the apelinergic system in pain modulation. 41TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Deslauriers J., Larouche A., Sarret P. and Grignon S. (2011). Neurochemical changes in schizophrenia are primed by the synergistic action of prenatal immune challenge and restraint stress. 41TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Deslauriers, J., *Belleville, K., *Kirby, K., *Beaudet, N., Sarret, P. and Grignon S. (2011). Suicide-related behaviors induced by social isolation in a model of schizophrenia. 41TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • René A., Martinez J., Cavelier F., *Tétreault P., *Beaudet N., Lepage M. and Sarret P. (2011). Synthesis of neurotensin analogues as potent antinociceptive agents. 3rd West Mediterranean Chemistry Meeting. (Article accepté).
  • *Dansereau M.A., *Murza A., *Beaudet N., Marsault E., Melik-Parsadaniantz S. and Sarret P. (2011). Behavioral evaluation of a CCR2 antagonist against clinically effective drugs in an animal model of arthritic pain. Annual Scientific Conference of the Canadian Arthritis Network. (Article accepté).
  • *Parent A., *Beaudet N., Bergeron J., *Bérubé P., Drolet G., Sarret P. and Gendron L. (2011). Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain. Annual Scientific Conference of the Canadian Arthritis Network. (Article accepté).
  • *Belkouch M., *Dansereau M.A., Pohl M, *Beaudet N., Chraibi A., Melik-Parsadaniantz S. and Sarret P. (2011). CCL2 increases Nav1.8 current and nociceptor excitability through a Gi/o dependent-mechanism. 8TH IBRO World congress of Neuroscience. (Article accepté).
  • *Barrière D., *Midavaine É., *Doré-Savard L., *Longpré J.M. and Sarret P. (2011). Effect of long-term morphine treatment on the progression of bone metastases. 43TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Murza A, Tremblay H, Karadereye F, *Parent A, *Beaudet N., Sarret P. and Marsault E. (2011). Structure-activity relationships of apelin derivatives; National Meeting of the Canadian Society for Chemisty. 94TH National Meeting of the Canadian Society for Chemisty. (Article accepté).
  • *Belkouch M., *Dansereau M.A., Pohl M, *Beaudet N., Chraibi A., Melik-Parsadaniantz S. and Sarret P. (2011). The Chemokine CCL2 enhances TTX-resistant Nav1.8 sodium currents in dissociated rat sensory neurons via a Gi/o-dependent mechanism. 10TH Société des Neurosciences. (Article accepté).
  • *Deslauriers J., Sarret P. and Grignon S. (2011). Synergistic disruption of prepulse inhibition by prenatal immune challenge and restraint stress. 13TH International Congress on Schizophrenia Research. (Article accepté).
  • *Parent A., Bergeron J., Beaudry H., *Belleville K., *Beaudet N., Sarret P. and Gendron L. (2010). A meaningful rat model for the study of anxiety caused by chronic inflammatory pain. Annual Scientific Conference of the Canadian Arthritis Network. (Article accepté).
  • *Doré-Savard L., Tremblay L., *Belleville K., Archambault M., Beaudoin J.F., Martinez J., *Beaudet N., Lecomte R., Lepage M. and Sarret P. (2010). Analgesic efficacy of NTS2 agonists in relieving breast tumor-induced bone pain. 40TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Belkouch M., *Begin-Lavallée V., *Beaudet N., Chraibi A., Melik-Parsadaniantz S. and Sarret P. (2010). CCL2 modulates Nav1.8 sodium channel activity in dorsal root ganglia neurons. 40TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Parent A., *Kirby K., *Beaudet N., Drolet G., Sarret P. and Gendron L. (2010). Effect of diazepam and morphine on anxiety-like behaviours induced by chronic pain. 40TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Doré-Savard L., Otis V., Tremblay L., *Belleville K., Archambault M., *Beaudet N., Lepage M., Gendron L. and Sarret P. (2010). Imaging, Behavioural and Neurochemical Characteristics of a Clinically Relevant Bone Cancer Pain Model. Annual Scientific Conference of the Canadian Arthritis Network. (Article accepté).
  • *Deslauriers J., Sarret P. and Grignon S. (2010). In vitro involvement of Akt/GSK-3 signaling pathway in antipsychotic-induced dopamine D2 receptor up-regulation. 40TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Lafrance M., *Roussy G., *Belleville K., Maeno H., *Beaudet N., Wada K. and Sarret P. (2010). Involvement of neurotensin receptors in stress-induced analgesia. 40TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Dansereau M.A., Pohl M., *Beaudet N., Melik Parsadaniantz S. and Sarret P. (2010). Potent Analgesic Effects of a CCR2 Antagonist on Inflammatory Pain. Annual Scientific Conference of the Canadian Arthritis Network. (Article accepté).
  • *Dansereau M.A., *Murza, A., *Beaudet N., Marsault E., Melik-Parsadaniantz S. and Sarret P. (2010). Pronociceptive role of spinal CCR2 receptors in inflammatory unilateral arthritis. 40TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Tétreault P., *Belleville K., Martinez J., *Beaudet N. and Sarret P. (2010). Reduced nerve-injury-induced neuropathic pain in NTS2 agonist-treated rats. 40TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Bégin-Lavallée V., *Dansereau M.A., Rose S.D., Jacobi A.M., *Beaudet N., Behlke M.A., Melik-Parsadaniantz S. and Sarret P. (2010). Spinal delivery of Dicer-substrate siRNA targeting CCR2 prevents the pronociceptive action of monocyte chemoattractant protein-1. 40TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Roussy G., *Lemire M., *Belleville K., *Beaudet N., Martinez, J. and Sarret P. (2010). Targeting neurotensin receptors for bone cancer pain relief. 40TH Annual Meeting-Society for Neurosciences. (Article accepté).
  • *Dansereau M.A., Pohl M., *Beaudet N., Melik-Parsadaniantz S. and Sarret P. (2010). A CCR2 antagonist to alleviate inflammatory pain. Annual Scientific Conference of the Canadian Arthritis Network. (Article accepté).
  • *Doré-Savard L., Tremblay L., *Belleville K., Archambault M., Beaudoin J.F., *Beaudet N., Lecomte R., Lepage M. and Sarret P. (2010). Neurotensin analog reveals an analgesic potential in metastasis-induced bone pain. Annual Scientific Conference of the Canadian Arthritis Network. (Article accepté).
  • *Parent A., *Beaudet N., Drolet G., Sarret P. and Gendron L. (2010). Temporal characterization of an animal model of anxiety-like behaviours caused by chronic pain. Annual Scientific Conference of the Canadian Arthritis Network. (Article accepté).
  • *Dansereau M.A., Pohl M., *Beaudet N., Melik-Parsadaniantz S. and Sarret P. (2010). A CCR2 antagonist to alleviate inflammatory pain. 13TH World Congress on Pain. (Article accepté).
  • *Bégin-Lavallée V., *Dansereau M.A., Rose S.D., Jacobi A.M., *Beaudet N., Behlke M.A., Melik-Parsadaniantz S. and Sarret P. (2010). Dicer-substrate-siRNA: A potential gene therapy approach to prevent nociceptive hypersensitivity caused by monocyte chemoattractant protein-1 in healthy rats. 13TH World Congress on Pain. (Article accepté).
  • *Belkouch M., *Begin-Lavallée V., *Beaudet N., Chraibi A., Melik-Parsadaniantz S. and Sarret P. (2010). Monocyte chemoattractant protein-1 enhances TTX-resistant sodium currents in isolated rat DRG neurons. 13TH World Congress on Pain. (Article accepté).
  • *Doré-Savard L., Tremblay L., *Belleville K., Archambault M., Beaudoin J.F., *Beaudet N., Lecomte R., Lepage M. and Sarret P. (2010). Neurotensin analog reveals an analgesic potential in metastasis-induced bone pain. 13TH World Congress on Pain. (Article accepté).
  • *Roussy G., *Lemire M., *Belleville K., *Beaudet N., Martinez J. and Sarret P. (2010). Targeting the neurotensinergic system to soothe bone cancer pain. 13TH World Congress on Pain. (Article accepté).
  • *Parent A., *Beaudet N., Drolet G., Sarret P. and Gendron L. (2010). Temporal characterization of an animal model of anxiety-like behaviours caused by chronic pain. 13TH World Congress on Pain. (Article accepté).
  • *Deslauriers J., Larouche A., Sarret P. and Grignon S. (2010). In vitro prevention, by -estradiol, of haloperidol-induced dopamine D2 receptor up-regulation. 4th Annual Meeting- Canadian Association for Neurosciences. (Article accepté).
  • *Deslauriers J., Larouche A., Sarret P. and Grignon S. (2010). Mechanisms underlying antipsychotics-induced dopamine D2 receptor up-regulation. 4th Annual Meeting- Canadian Association for Neurosciences. (Article accepté).
  • *Doré-Savard, L., Tremblay L., Archambault M., Beaudoin J.F., *Beaudet N., Turcotte E., Lecomte R., Sarret P. and Lepage M. (2010). Toward a better understanding of bone metastatic pain: a multimodal micro-imaging approach. 18TH International Society for Magnetic Resonance in Medicine, ISMRM. (Article accepté).

Propriétés intellectuelles

Brevets

  • Active Acoustic Pressure Mapping System. US 61/679,232. (Demande en cours).
  • Chemokines : a novel therapeutics approach for the treatment of pain. (Demande en cours).
  • Utilisation des Dicer Duplex siRNA dans le traitement central de la douleur chronique. (Demande en cours).

Autres contributions

Cours enseignés

  • Endocrinologie cellulaire et moléculaire (8 hres/année). Université de Sherbrooke. Canada.
  • Hormones et système nerveux central. PHS 710. Université de Sherbrooke. Canada.
  • Le cerveau: en conditions physiologiques et pathologiques (3 hres/année). Université de Sherbrooke. Canada.
  • Neurophysiologie de la douleur (4 hres/année). GDL 720. Université de Sherbrooke. Canada.
  • Pharmacologie du comportement (6 hres/année). Université de Sherbrooke. Canada.
  • Récepteurs et transducteurs (4 hres/année). Université de Sherbrooke. Canada.
  • Évaluation de la douleur (4 hres/année). GDL 730. Université de Sherbrooke. Canada.

Gestion d'évènements

  • Membre du Comité organisateur. 15th Annual Joint Meeting of the Great Lakes GPCR Retreat and Cubl des récepteurs à sept domaines transmembranaires du Québec. (Conférence).
  • Membre du Comité organisateur. 37e Colloque de la Société de Neuroendocrinologie et 4e Colloque franco-québécois. (Conférence).
  • Organisateur. La neurotensine et ses analogues pour le traitement de la douleur chronique d'origine cancéreuse dans le cadre des rencontres scientifiques universitaires Sherbrooke – Montpellier. Sherbrooke, 5-8 octobre 2010. (Conférence).
  • Organisateur. Symposium satellite « Francophonie and Pain : Translational Challenges » du 13e congrès mondial sur la douleur. (Conférence).

Activités de collaboration internationale

  • Initiateur. (2008). Collaboration avec le Dr Keiji Wada, Directeur de l'Institut des neurosciences de Tohyo, Japon, sur la thématique: Douleur et stress.
  • Initiateur. (2007). Cotutelle de thèse avec le Dr. Stéphane Mélik-Parsadaniantz sur la thématique des chimiokines. Cette cotutelle s’inscrit dans des accords d’échange que j’ai mis en place en 2007 entre l’Université de Sherbrooke et l’Université Paris VI (France) pour le développement des plateformes neurosciences et de la recherche biomédicale.
  • Initiateur. (2007). Rôle central des récepteurs neurotensine. Collaboration avec le Pr Jean Martinez (Université de Montpellier, France).

Présentations

  • (2016). Nouveaux acteurs de la voie de sécrétion régulée impliqués dans la modulation de la douleur. 41e Colloque de la Société de Neuroendocrinologie.
  • (2016). Chimiokines et réactivité gliale dans la modulation de la douleur chronique cancéreuse. 41e Colloque de la Société de Neuroendocrinologie.
  • (2016). Crossing the blood brain barrier for delivery of analgesic peptides. 16th World Congress of Pain, IASP.
  • (2015). Déjouer la barrière hématoencéphalique pour traiter la douleur chronique. Faculté de médecine dentaire, Université de Montréal.
  • (2014). Les complications neurologiques du diabète ? La neuropathie diabétique. Café scientifique, IRSC.
  • (2014). Characterization of a New Brain-Penetrant Angiopep2-Neurotensin Derivative (ANG2002) with Antinociceptive Properties. The 10Th annual PEGS Meeting. Boston.
  • (2013). Pharmacological inhibition of the CCL2/CCR2 chemokinergic system reduces cancer-related pain behaviors. 43TH Annual Meeting-Society for Neurosciences.
  • (2013). La barrière hématoencéphalique: Un obstacle au traitement de la douleur chronique. 4ième rencontre Montpellier-Sherbrooke Les récepteurs couplés aux protéines G à Sherbrooke et Montpellier. Montpellier.
  • (2013). Use of peptide technology for analgesic brain delivery. CIHR training program in biological therapeutics. Toronto.
  • (2013). Mieux comprendre le cerveau. Parlons Sciences. Sherbrooke.
  • (2012). Spinal NTS2 agonists reverse signs of neuropathic pain. 42TH Annual Meeting-Society for Neurosciences.
  • (2010). Approches non-opioïdes pour le traitement de la douleur. 36e Colloque de la Société de Neuroendocrinologie et 1er Colloque franco-italien. Nice.
  • (2010). Le récepteur NTS2: Une nouvelle cible thérapeutique pour le traitement de la douleur chronique. Rencontre Montpellier-Sherbrooke. Montpellier.
  • (2010). Les récepteurs de la neurotensine : de nouvelles cibles thérapeutiques pour le traitement de la douleur chronique. IFR 79 - Santé Auvergne. Clermont-Ferrand.
  • (2010). Douleur due au cancer: vers un modèle cliniquement représentatif. IFR 79 - Santé Auvergne. Clermont-Ferrand.
  • (2010). Utilité des modèles animaux pour la compréhension des mécanismes de la douleur et la prédiction de l’efficacité analgésique chez l’humain. 5e Édition des journées d'étude des comités d'éthique de la recherche et de leurs partenaires. Montréal, Québec, Canada.
  • (2010). Rôle des récepteurs de la neurotensine dans le contrôle de la douleur. Angiochem. Montréal.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.