Guérin, Brigitte

Professeure, Faculté de médecine et des sciences de la santé
FMSS Dép. médecine nucléaire et radiobiologie

Coordonnées

Courriel


819-821-8000, poste 15285


Site Web

Diplômes

(2007) Post-doctorate (Postdoctorate in Chemistry). Université de Sherbrooke.

(1995) Post-doctorate (Postdoctorate in Chemistry). Université de Montréal.

(1994) Doctorate (Doctorate in Chemistry). Université de Sherbrooke.

(1988) Bachelor's (Bachelor in Chemistry). Université de Sherbrooke.

Présentation

Sujets de recherche

Chemical Synthesis and Catalysis, Organic Molecules and Biomolecules, Cancer Diagnosis and Detection, Breast Cancer, Prostate Cancer.

Disciplines de recherche

Nuclear Medicine, Chemistry.

Mots-clés

Bifunctional Chelator, In vitro and in vivo animal studies, PET tracer development, Preclinical imaging, Radiochemistry, Radiolabelling, Radiometal for targeted radiotherapy, Radiometal production by Cyclotron, Theranostic development, Translational studies.

Intérêts de recherche

Trained in organic chemistry, medicinal chemistry and radiochemistry, my research focuses on the development of radiometal produced by cyclotron, bifuctional chelators for radiometal labeling and theranostics for early detection and treatment of cancer recurrence. These are important tools that help characterize and accurately pinpoint the exact stage of development of the disease. This research paves the way to personalized medicine and on-target cancer treatments.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2020) Research Chair Jeanne et Jean-Louis Lévesque de radiobiologie. Université de Sherbrooke. (Prize / Award).
  • (2019) 2018 Clara Benson Award Winner. Sponsored by the Canadian Council of University Chemistry Chairs (CCUCC),. Chemical Institute of Canada/Canadian Society for Chemistry. (Prize / Award).
  • First Winner- Category Quality of Care and Services: 68Ga-DOTA-TATE--. Centre intégré universitaire de santé et des services sociaux de l'Estrie (CIUSSE)-CHUS. (Distinction).
  • Mérite Estrien for my leadership in the cyclotron-produced Tc-99m project. La Tribune for a regional recognition. (Distinction).
  • Prix d'excellence de groupe, catégorie Rayonnement for a national effort to develop an alternative production method for Tc-99m using cyclotron. Centre Hospitalier Univ. de Sherbrooke. (Distinction).
  • Prix du Doyen au Gala du Mérite Dean's Award Production of Tc-99m by cyclotron. Université de Sherbrooke. (Distinction).

Financement

Grant. (Awarded). Principal Applicant. Tools for the preparation of peptide-based radioligands. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery grant. 145000 $ (2019-2024).

Grant. (Awarded). Co-applicant. Imaging, understanding, and managing radiotherapy inflammation and radiation necrosis. Canadian Institutes of Health Research (CIHR). Project grant. 914175 $ (2017-2022).

Grant. (Awarded). Co-investigator. Early detection and in vivo estrogen receptor status determination of uterine and ovarian cancers using the novel PET tracer 4FMFES: a phase I/II study. Canadian Cancer Society. Innovative Grants - 2018. 199672 $ (2018-2021).

Grant. (Awarded). Principal Investigator. Optimizing care for castration-resistant prostate cancer patients using triple-tracer molecular imaging and targeted radioligand therapy. Oncopole. Oncopole-EMC2. 1500000 $ (2018-2021).

Grant. (Awarded). Principal Investigator. APPROVISIONNEMENT EN TECHNÉTIUM AU QUÉBEC. Ministère de la Santé et des Services Sociaux (MSSS). N/A. 859905 $ (2017-2020).

Research Chair. (Awarded). Principal Applicant. Chaire Jeanne et Jean-Louis Lévesque de radiobiologie. Fonds Institutionel de Recherche de l'Université de Sherbrooke. Chaire institutionnelle. 575000 $ (2016-2020).

Grant. (Awarded). Principal Applicant. Conception et réalisation d'une unité de synthèse automatisée pour la préparation du [18F]-FMPEP-d2.. Natural Sciences and Engineering Research Council of Canada (NSERC). EGP - Subventions d'engagement partenarial pour les universités. 25000 $ (2019-2020).

Grant. (Awarded). Co-investigator. Imaging agents for the early detection of amyloid and neurodegenerative diseases. Fonds de recherche du Québec - Santé (FRQS). Partenariat MOST/ FRQNT/FRSQ. 150000 $ (2017-2020).

Grant. (Awarded). Principal Applicant. Optimiser les soins des patients atteints du cancer de la prostate résistant à la castration. Fondation du CHUS/Bombardier produits récréatifs. N/A. 300000 $ (2019-2020).

Grant. (Awarded). Co-applicant. Biopsie corps entier du cancer du sein par imagerie TEP: Meilleur diagnostic non-invasif pour un traitement plus personnalisé. Fonds Jean-Luc Mongrain et de la Fondation du CHUS. N/A. 50000 $ (2018-2019).

Grant. (Awarded). Principal Investigator. Développement d’un nouveau traceur TEP de l’activité microgliale et validation en contexte de douleur chronique. RQRD-RBIQ. Concours de subvention inter-réseaux RQRD-RBIQ 2017-2018. 20000 $ (2018-2019).

Grant. (Awarded). Co-investigator. Vers l’exploitation de biopsies pancorporelles non-invasives dans le cancer du sein : développement d’une capacité multicentrique en vue d’une étude de phase II d’imagerie TEP ciblant les récepteurs d’estrogène (ER) et HER2 à l’aide du 4FMFES et du 8. RBIQ. INITIATIVE STRATÉGIQUE. 25000 $ (2018-2019).

Grant. (Awarded). Co-applicant. Imagerie TEP des récepteurs d’œstrogène au 4FMFES : du cancer du sein vers les cancers gynécologiques. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke (CRCHUS). PAFI. 25000 $ (2018-2019).

Grant. (Completed). Principal Applicant. Fight hypoxia for personalized brain cancer therapy. Merck Sharp & Dohme. Don de Merck Sharp & Dohme. 50000 $ (2016-2017).

Publications

Articles de revue

  • A.-M. Carreau, C. Noll, D. P. Blondin, F. Frisch, M. Nadeau, M. Pelletier, S. Phoenix, S. C. Cunnane, B. Guérin, E. E. Turcotte, L. Biertho2 A. Tchernof, and A. C. Carpentier. (2020). Bariatric surgery rapidly decreases cardiacdietary fatty acid partitioning and hepatic insulin resistance throughincreased intra-abdominal adipose tissue storage and reduced spillover in type2 diabetes. Diabetes, N/A, N/A. (Accepted).
  • C. Noll; É. Montastier; M. Amrani; M. Kunach; F. Frisch; M. Fortin; L. Bouffard; S. Dubreuil; S. Phoenix; S. C. Cunnane; B. Guérin; E. E. Turcotte; M, Laville and A. C. Carpentier. (2020). Seven-day overfeeding enhances adipose tissuedietary fatty acid storage and decreases myocardial and muscle dietary fattyacid partitioning in healthy subjects. Am J Physiol Endocrinol Metab, 318(2), E286-E296. (Published).
  • A. H. Alnahwi, S. Tremblay, S. Ait-Mohand, V. Dumulon-Perreault, J.-F. Beaudoin and B. Guérin. (2019). Automated radiosynthesisof 68Ga for large-scale routine production using 68Zn pressed target. Applied Radiation and Isotopes, N/A, N/A. (Submitted).
  • T, Tippayamontri, B. Guérin, R. Ouellet, O. Sarrhini, J. Rousseau, R. Lecomte, B. Paquette and L. Sanche. (2019). Intra-tumoral18F-FLT infusion in metabolic targeted radiotherapy. EJNMMI Research, 9, 33. (Published).
  • J.-L., Beaudeau*; V. Blais, B. Holleran, G. Pineyro, B. Guérin, L. Gendron, Y. Dory. (2019). N-guanidyland C-tetrazole Leu-Enkephalin Derivatives: Efficient Delta Opioid ReceptorAgonists with Improved Pharmacological Properties. ACS Chemical Neuroscience, N/A, N/A. (Accepted).
  • H. Ali; J.E. van Lier; B. Guérin. (2019). Radiolabeled BODIPYs: AnOverview. J. Porphyrins Phthalocyanines, 23, 781–796. (Published).
  • H. Ali; B. Guérin; J.E. van Lier. (2019). gem-DiBromovinylBoron Dipyrrins: Synthesis, Spectral Properties and Crystal Structures. Dalton Trans., 48(30), 11492-11507. (Published).
  • A. H. Alnahwi*, S. Tremblay*, B. Guérin. (2018). ComparativeStudy with 89Y-foil and 89Y-pressed Targets for theProduction of 89Zr. Appl. Sci., 8, 1579. (Published).
  • A. Kwiatkowska, F. Couture, S. Ait-Mohand, R. Desjardins, Y. L. Dory, B. Guérin, and R. Day. (2018). Enhancedanti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed intoan albumin-bound tumor-targeting prodrug. Scientific Reports, 9:2118, 1-12. (Revision Requested).
  • N. Mansour*, M. Paquette*, S. Ait-Mohand*, V. Dumulon-Perreault*, B. Guérin. (2018). Evaluation of a novel GRPR antagonist for prostate cancer PET imaging: [64Cu]-DOTHA2-PEG-RM26. Nuclear Medicine and Biology, 56, 31–38. (Published).
  • D. Bella Ndong*,V Blais, B. J. Holleran, A. Proteau-Gagne, I. Cantin-Savoie, W Robert, J.-F. Nadon, S. Beauchemin, R. Leduc, G Pineyro, B. Guerin, L. Gendron, Y. L. Dory. (2018). Explorationof the fifth position of leu-enkephalin and its role in binding and activatingdelta (DOP) and mu (MOP) opioid receptors. Peptide Science, 111(1), e24070. (Published).
  • M. Paquette,* É. Lavallée, S. Phoenix*, R. Ouellet*, H. Senta, J. E. van Lier, B. Guérin, R. Lecomte, and É. E. Turcotte. (2018). Improved Estrogen Receptor assessment by PET using the novel tracer 4FMFES over FES inER+ breast cancer patients in an ongoing phase II clinical trial. J. Nucl. Med., 59, 197-203. (Published).
  • S. Beaudoin*, M. Paquette*, L. Fafard-Couture, M.A. Tremblay, R. Lecomte, B. Guerin, and J.V. Leyton. (2018). Initial evaluation of antibody-conjugates modified with viral-derived peptides for increasingcellular accumulation and improving tumor targeting. Journal of Visualized Experimentation (JOVE), 133, N/A. (Published).
  • M. Paquette*, S. Beaudoin*, M.-A.Tremblay, S. Jean, A. Lopez, R. Lecomte, B. Guérin, M. Bentourkia, R. Sabbagh, J Leyton. (2018). NLS-cholic acid conjugation to IL-5R?-specific antibody improves cellular accumulation andin vivo tumor-targeting properties in a bladder cancer model. Bioconjug. Chem., 29(4), 1352–1363. (Published).
  • René Ouellet*, Sébastien Tremblay*, Brigitte Guérin. (2017). A new simple method for the purification of sodium pertechnetate produced by cyclotron and therecycling of molybdenum. Nuclear Medicine and Biology, (Submitted).
  • S. Osati,* H. Ali*, F. Marques, M. Paquette*, S. Beaudoin*, B. Guerin, J. V. Leyton, J. E. van Lier. (2017). BODIPY-17a-ethynylestradiol conjugates: Synthesis,fluorescence properties and receptor binding affinities. Bioorganic & Medicinal Chemistry Letters, 27, 443–446. (Published).
  • D.P. Blondin, H. C. Tingelstad, C.Noll, F. Frisch, S. Phoenix*, B. Guérin, É. E. Turcotte, D. Richard, F Haman, A. C. Carpentier. (2017). Dietary fatty acid metabolism of brown adipose tissue in cold-acclimatedmen. Nature Communications, 14146, N/A. (Published).
  • N. Mansour,* V. Dumulon-Perreault*, S. Ait-Mohand*, M. Paquette,* R. Lecomte, B. Guérin. (2017). Impact of charged linker on biodistribution of [64Cu]NOTA peptide-based GRPR antagonists. Labelled Compounds and Radiopharmaceuticals, 60(4), 200-212. (Published).
  • D.P. Blondin, F. Frisch, S. Phoenix*, B. Guérin, É. E. Turcotte, D. Richard, F. Haman, A. C. Carpentier. (2017). Inhibition of intracellular triglyceride lipolysis suppresses coldinduced brown adipose tissue metabolism and increases shivering in humans. Cell Metab., 25, 438-447. (Published).
  • F. Panet, F. Couture*, A. Kwiatkowska, R. Desjardins, B. Guérin , R. Day. (2017). PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation andtumor progression. European Journal of Cell Biology, 96(5), 469-475. (Published).
  • S.V. Selivanova*, É. Lavallée, H. Senta, L. Caouette, A. J. McEwan, B. Guérin, R. Lecomte, É. Turcotte. (2017). Phase I clinical trial using sodium pertechnetate 99mTc produced with a medium-energycyclotron. Journal of Nuclear Medicine, 58(5), 791-798. (Published).
  • S. Osati*, H. Ali*, B. Guérin and J. E. van Lier. (2017). Steroid-photosensitizerconjugates: Syntheses and applications. Journal of Porphyrins and Phthalocyanines, 21, 701–730. (Published).
  • A Pirisedigh,* V. D. Blais, S. Ait-Mohand*, K. Abdallah, B. J. Holleran, R. Leduc, Y. L. Dory, L. Gendron, B. Gue?rin. (2017). Synthesis and Evaluation of a Novel 64Cu/NOTA-TIPP Conjugate, a Selective?-Opioid Receptor PET Imaging Agent. Organic Letters, 19(8), 2018-2021. (Published).
  • S. Osati*; H. Ali*; B. Guérin; J. E. van Lier. (2017). Synthesis and spectral properties of estrogen- and androgen-BODIPY conjugates. Steroids, 123, 27–36. (Published).
  • M. Paquette,* L.-G. Perez-Vilera, S. Beaudoin*, N. Ekindi-Ndongo, P.-L. Boudreaut, M.-A. Bonin, M.-C. Battista, M. Bentourkia, A. Lopez, R. Lecomte, E. Marsault, B. Guerin, R. Sabbagh, and J. Leyton. (2017). Targeting IL-5R? with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer. OncoImmunology, 6(10), e1331195. (Published).
  • J.-F.Nadon,* K. Rochon, G. Langlois, S. Grastilleur, B. Guérin, L. Gendron, Y. Dory. (2017). ZSynthesis of Gly-?[()CF=CH]-Phe,a fluoroalkene dipeptide isostere and its incorporation into a Leu-enkephalinpeptidomimetic. ACS Chemical Neuroscience, 8(1), 40-49. (Published).
  • M. Shi,* B. Paquette, T. Thippayamontri, L. Gendron, B. Guérin & L. Sanche. (2016). Increased radio-sensitivity of colorectal tumor with intra-tumoral injection of low doseof gold nanoparticles. International Journal of Nanomedicine, 11, 5323-5333. (Published).
  • C. Zhang, J. Pan, K.-S. Lin, I. Dude, J. Lau, H. Merkens, S. Jenni, B. Guérin, F. Bénard. (2016). Targeting the neuropeptide Y1 receptor for cancer imaging by positron emission tomographyusing novel truncated peptides. Molecular Pharmaceutics, N/A(7), 3657-3664. (Published).
  • D P. Blondin, S M. Labbé, S Phoenix*, B Guérin, É E. Turcotte, D Richard, A C. Carpentier, and F Haman. (2015). Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic response in healthy men. Journal of Physiology, 593(3), 701-14. (Published).
  • Couture F*, Ly K, Levesque C, Kwiatkowska A, Ait-Mohand S*, Desjardins R, Guérin B, Day R. (2015). Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity. Biomed Res Int., 2015, 824014. (Published).
  • C. Levesque , F. Couture*, A .Kwiatkowska, R. Desjardins , B. Guérin , W. Neugebauer, R. Day. (2015). PACE4 Inhibitors and Their Peptidomimetic Analogs Block Prostate Cancer Tumor Progression Through Quiescence Induction, Increased Apoptosis and Impaired Neovascularisation. Oncotarget, 6(6), 3680-93. (Published).
  • Selivanova SV*, Lavallée É, Senta H, Caouette L, Sader JA, van Lier EJ, Zyuzin A, van Lier JE, Guérin B, Turcotte É, Lecomte R. (2015). Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications. J Nucl Med., 56(10), 1600-8. (Published).
  • D. P. Blondin, S. M. Labbé, C. Noll, M. Kunach, S. Phoenix*, B Guérin, É E. Turcotte, F Haman, D Richard, A C. Carpentier. (2015). Selective impairment of glucose, but not fatty acid or oxidative metabolism in brown adipose tissue of subjects with type 2 diabetes. Diabetes, 64(7), 2388-97. (Published).
  • Noll C, Kunach M, Frisch F, Bouffard L, Dubreuil S, Jean-Denis F, Phoenix S*, Cunnane SC, Guérin B, Turcotte EE, Carpentier AC. (2015). Seven-day caloric and saturated fat restriction increases myocardial dietary fatty acid partitioning in impaired glucose-tolerant subjects. Diabetes, 64(11), 3690-9. (Published).
  • S. Ait-Mohand*, C. Denis,* G. Tremblay,* M. Paquette* and B. Guérin. (2014). Development of Bifunctional Chelates Bearing Hydroxamate Arms for Highly Efficient 64Cu Radiolabeling. Organic Letters, 16, 4512-4515. (Published).
  • M Kunach, C Noll, S Phoenix*, B Guérin, J-P Baillargeon, E E. Turcotte, AC. Carpentier. (2014). Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans. Diabetes, 64(7), 2432-41. (Published).
  • Labbé SM , Noll C , Grenier-Larouche T , Kunach M , Bouffard L , Phoenix S*, Guérin B , Baillargeon JP , Langlois MF , Turcotte EE , Carpentier AC. (2014). Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance. American journal of physiology. Endocrinology and metabolism, 306(12), E1388-E1396. (Published).
  • Blondin DP , Labbé SM , Christian Tingelstad H , Noll C , Kunach M , Phoenix S*, Guérin B , Turcotte EE , Carpentier AC , Richard D , Haman F. (2014). Increased brown adipose tissue oxidative capacity in cold-acclimated humans. The Journal of clinical endocrinology and metabolism, 99(3), E438–E446. (Published).
  • F Couture*, C Levesque, V Dumulon-Perreault, S Ait-Mohand, F D’Anjou, R Day*, B Guérin*. (2014). PACE4-based molecular targeting of prostate cancer using an engineered 64Cu-radiolabeled peptide inhibitor. Neoplasia, 16(8), 634-643. (Published).
  • Ranyuk E,* Lebel R , Bérubé-Lauzière Y , Klarskov K , Lecomte R , van Lier JE , Guérin B. (2013). (68)Ga/DOTA- and (64)Cu/NOTA-Phthalocyanine Conjugates as Fluorescent/PET Bimodal Imaging Probes. Bioconjugate chemistry, 24(9), 1624–1633. (Published).
  • Inkster J*, Lin KS , Ait-Mohand S*, Gosselin S*, Bénard F , Guérin B, Pourghiasian M , Ruth T, Schaffer P, Storr T. (2013). 2-Fluoropyridine prosthetic compounds for the (18)F labeling of bombesin analogues. Bioorganic & medicinal chemistry letters, 23(13), 3920-6. (Published).
  • Beaudoin J, Ekici S, Daldal F, Ait-Mohand S*, Guérin B, Labbé S. (2013). Copper transport and regulation in Schizosaccharomyces pombe. Biochem Soc Trans, 41(6), 1679–1686. (Published).
  • M. Kunach, C. Noll, S.M. Labbé, T. Grenier-Larouche, L. Bouffard, S. Phoenix, B. Guérin, J.P. Baillargeon, M.F. Langlois, E.E. Turcotte, A.C. Carpentier. (2013). Improved Cardiopulmonary Functional Capacity Following a One-Year Lifestyle Intervention Regimen Does Not Explain Improved Postprandial Myocardial Dietary Fatty Acid Metabolism in Patients with Impaired Glucose Tolerance. Can. J. Diabetes, 37(S4), S50. (Published).
  • Ranyuk E,* Cauchon N , Klarskov K , Guérin B , van Lier JE. (2013). Phthalocyanine-Peptide Conjugates: Receptor-Targeting Bifunctional Agents for Imaging and Photodynamic Therapy. Journal of Medicinal Chemistry, 56(4), 1520–1534. (Published).
  • Rochon K , Proteau-Gagné A, Bourassa P , Nadon JF , Côté J , Bournival V , Gobeil F , Guérin B, Dory YL , Gendron L. (2013). Preparation and Evaluation at the Delta Opioid Receptor of a Series of Linear Leu-Enkephalin Analogues Obtained by Systematic Replacement of the Amides. ACS chemical neuroscience, DOI: 10.1021/cn40005, 1204-16. (Published).
  • C. Noll, M. Kunach, S. Phoenix*, B. Guérin, E.E. Turcotte, A.C. Carpentier. (2013). Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Subjects with Impaired Glucose Tolerance. Can. J. Diabetes, 37(S4), S70. (Published).
  • Proteau-Gagné A , Rochon K , Roy M , Albert PJ , Guérin B, Gendron L , Dory YL. (2013). Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity. Bioorganic & medicinal chemistry letters, 23(19), 5267-9. (Published).
  • Lebel, R., Zarifyussefian, N., Letendre-Jauniaux, M., Daigle, O., Ranyuk, E.*, Van Lier, J., Guérin, B., Lecomte, R., Massonneau, M., Ducharme, M.-E., and Bérubé Lauzière,. (2013). Ultra-high sensitivity detection of bimodal probes at ultra-low noise for combined fluorescence and positron emission tomography imaging. Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, SPIE BiOS - Photonics, 85740M, 1-7. (Published).
  • S M. Labbé, É E. Turcotte, B Guérin,R Lecomte et A C. Carpentier. (2012). Avancées de l’imagerie par tomographie d’émission par positrons pour l’élucidationdes mécanismes menant aux complications cardiométaboliques de l’obésité. Médecine Sciences Amérique, 1(4), 135-150. (Published).
  • Ouellet V, Labbé SM, Blondin DP, Phoenix S*, Guérin B, Haman F, Turcotte EE, Richard D, Carpentier AC. (2012). Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. The Journal of clinical investigation, 122(2), 545-52. (Published).
  • P. Fournier,* V. Dumulon-Perreault*, S. Ait-Mohand*, R. Langlois, F. Bénard, R. Lecomte and B. Guérin. (2012). Comparative study of 64Cu/NOTA-[D-Tyr6,?Ala11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging. EJNMMI Res., 2(8), 8. (Published).
  • Bessi VL , Labbé SM, Huynh DN, Ménard L, Jossart C, Febbraio M, Guérin B, Bentourkia M, Lecomte R, Carpentier AC, Ong H, Marleau S. (2012). EP 80317, a selective CD36 ligand, shows cardioprotective effects against post-ischaemic myocardial damage in mice. Cardiovascular research, 96(1), 99-108. (Published).
  • Labbé SM, Grenier-Larouche T, Noll C , Phoenix S*, Guérin B, Turcotte EE, Carpentier AC. (2012). Increased myocardial uptake of dietary fatty acids linked to cardiac dysfunction in glucose-intolerant humans. Diabetes, 61(11), 2701-10. (Published).
  • Fournier P,* Dumulon-Perreault V*, Ait-Mohand S*, Tremblay S*, Bénard F, Lecomte R, Guérin B. (2012). Novel radiolabeled peptides for breast and prostate tumor PET imaging: (64)Cu/and (68)Ga/NOTA-PEG-[D-Tyr(6),?Ala(11),Thi(13),Nle(14)]BBN(6-14). Bioconjugate chemistry, 23(8), 1687-93. (Published).
  • A. Radulska, S. Ait-Mohand*, V. Dumulon-Perreault*, R. Lebel, R. Zriba, B. Guérin, W.Neugebauer, M. Lepage. (2012). Stability studies on MMP-2 specific peptides for the preparation of molecular probes. Proceedings of the 32nd European Peptide Symposium, George Kokotos, Violetta Constantinou-Kokotou, John Matsoukas (Editors)European Peptide Society, N/A, 228-9. (Published).
  • Inkster JA, Liu K, Ait-Mohand S*, Schaffer P, Guérin B, Ruth TJ, Storr T. (2012). Sulfonyl fluoride-based prosthetic compounds as potential (18) f labelling agents. Chemistry, A Europeen Journal, 18(35), 11079-87. (Published).
  • Ait-Mohand S, Fournier P,* Dumulon-Perreault V, Kiefer GE, Jurek P, Ferreira CL, Bénard F, Guérin B. (2011). Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates. Bioconjugate chemistry, 22(8), 1729-35. (Published).
  • A. Proteau-Gagné, J.-F. Nadon, S. Bernard, B. Guérin,* L. Gendron* and Y. L. Dory. (2011). Kinetic deconjugation: a gateway to the synthesis of Xxx-Gly (E)-alkene dipeptide isosteres. Tetrahedron Letters, 52(49), 6603-6605. (Published).
  • Labbé SM , Croteau E , Grenier-Larouche T , Frisch F , Ouellet R , Langlois R , Guérin B , Turcotte EE , Carpentier AC. (2011). Normal postprandial nonesterified fatty acid uptake in muscles despite increased circulating fatty acids in type 2 diabetes. Diabetes, 60(2), 408-15. (Published).
  • Labbé SM, Grenier-Larouche T, Croteau E, Normand-Lauzière F, Frisch F, Ouellet R, Guérin B, Turcotte EE, Carpentier AC. (2011). Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography. Am J Physiol Endocrinol Metab., 300(3), E445-53. (Published).
  • Ranyuk ER,* Cauchon N, Ali H, Lecomte R, Guérin B, van Lier JE. (2011). PET imaging using 64Cu-labeled sulfophthalocyanines: synthesis and biodistribution. Bioorg Med Chem Lett., 21(24), 7470-3. (Published).
  • Ali H, Ait-Mohand S, Gosselin S,* van Lier JE, Guérin B. (2011). Phthalocyanine-peptide conjugates via palladium-catalyzed cross-coupling reactions. The Journal of Organic Chemistry, 76(6), 1887-90. (Published).
  • S. M. Aly,* H. Guernon, B. Guérin, and P. D. Harvey. (2011). Polyoligopeptides Functionalized Zinc(II)porphyrins. A Step Towards Artificial Hemes. J. Porphyrins Phthalocyanines, 15, 1–12. (Published).
  • B. Guérin, A. Zyuzin, S. Tremblay, E. J. van Lier, S. Rodrigue, J. A. Rousseau, V. Dumulon-Perreault, R. Lecomte, and J. E. van Lier. (2010). Comparing Cyclotron- with generator- produced 99mTc. In Technetium and Other Radiometals in Chemistry and Medicine, Edited by Ulderico Mazzi, William C. Eckelman, Wynn A. Volkert, Non applicable, 497-500. (Published).
  • Guérin B, Tremblay S, Rodrigue S, Rousseau JA, Dumulon-Perreault V, Lecomte R, van Lier JE, Zyuzin A, van Lier EJ. (2010). Cyclotron production of 99mTc: an approach to the medical isotope crisis. J Nucl Med., 51(4), 13N-6N. (Published).
  • Guérin B , Ait-Mohand S , Tremblay MC , Dumulon-Perreault V,* Fournier P,* Bénard F. (2010). Total solid-phase synthesis of NOTA-functionalized peptides for PET imaging. Organic letters, 12(2), 280-3. (Published).

Documents de travail

  • Véronique Dumulon-Perreault, Etienne Croteau, Samia Ait-Mohand, Jean-François Beaudoin, René Ouellet, Jacques A. Rousseau, Éric, Lavallée, Roger Lecomte, Éric Turcotte, Brigitte. Positron emitting tracers as alternatives to 99mTc-radiopharmaceuticals for pulmonary ventilation/perfusion scan.

Articles de conférence

  • G. Charest*, S. Ait-Mohand*, O. Sarrhini, J. Rousseau, D. Stanimirovic, R. Hutchison, D. Fortin and B. Guérin. (2018). Measurement of blood brain barrier transport using radiolabeled antibodies. ESRR’18 – 19th European Symposium on Radiopharmacy and Radiopharmaceuticals. (Published).
  • G. Charest*, S. Ait-Mohand*, O. Sarrhini, J. Rousseau, D. Stanimirovic, R. Hutchison, D. Fortin and B. Guérin. (2018). Radiolabeled antibodiesto validate blood brain barrier penetration. Society of Nuclear Medicine Annual Meeting, SNMMI 2018. (Published).
  • A. H. Alnahwi*, S. Tremblay*, B. Guérin. (2017). 89Zr production via the 89Y(p,n)89Zrreaction using pressed target. 100th Canadian Chemistry Conference and Exhibition. Symposium in the Biological and Medicinal Chemistry Division. (Published).
  • M. Paquette*, V. Dumulon-Perreault*, S. Ait-Mohand*, B. Guérin. (2017). A New 64Cu-Labeled,Metabolic-Resistant Peptide with Nanomolar Affinity for NPY-Y1R for BreastCancer Targeting. EANM’17. (Published).
  • M. Paquette*, S. Ait-Mohand*, V. Dumulon-Perreault, F. Bénard, B. Guérin. (2017). A Novel 64Cu/NOTA-labeled Peptide with High Metabolic-resistance and NPY-Y1R Affinity. 100th Canadian Chemistry Conference and Exhibition. Symposium in the Biological and Medicinal Chemistry Division. (Published).
  • M. Paquette*, S. Beaudoin*, S. Phoenix*, L. Fafard-Couture, É. E. Turcotte, B. Guérin, R. Lecomte, J. V. Leyton. (2017). A Successive Triple PET Tracer Approach to Characterize ER and HER2 Status In Vivo in a Breast Cancer Mouse Xenograft Model. EANM’17. (Published).
  • B Guérin, M Savard, V Dumulon-Perreault, C Dubuc, S. Ait-Mohand*, F Gobeil Jr. (2017). A new 64Cu-radiolabeledpeptide conjugate for kinin B1R positive tumors. 22nd International Symposium on Radiopharmaceutical Sciences (ISRS 2017). (Published).
  • G. Charest*, O. Sarrhini, D. Fortin, D. Stanimirovic, R. Gabathuler, B. Guérin. (2017). Antibody-based PET imaging of brain cancer cells infiltration.SNO-SCIDOT joint conference ontherapeutic delivery to the CNS. SNO-SCIDOT joint conference on therapeutic delivery to the CNS. (Published).
  • B. Guérin, R. Ouellet*, S. Tremblay*. (2017). A simple method for the purification of Technetium-99m produced by cyclotron and the recycling of molybdenum. 22nd International Symposium on Radiopharmaceutical Sciences (ISRS 2017). (Published).
  • M. Paquette*, É. Lavallée, S. Phoenix*, H. Senta, B. Guérin, J. E. van Lier, R. Lecomte, É. E. Turcotte. (2017). Combined FDG and 4FMFES PET Imaging in ER+ Breast Cancer Patients for Improved Diagnostic andPrognostic Value. EANM’17. (Published).
  • M. Paquette*, S. Phoenix*, J. A. Rousseau, O. Sarrhini, B. Guérin, É. E. Turcotte, R. Lecomte. (2017). Cross-Species Physiological Assessment of Brain Estrogen Receptor Expression Using 4FMFES PET Imaging. EANM’17. (Published).
  • S. Phoenix*, S. Tremblay*, S. Ait-Mohand*, R. Ouellet*, P.Thibault, H. Senta, L. Caouette and B. Guérin. (2017). Gallium-68 DOTATATE Production with an Automated Synthesis System. 100th Canadian Chemistry Conference and Exhibition. Symposium in the Biological and Medicinal Chemistry Division. (Published).
  • A. H. Alnahwi*, S. Tremblay*, B. Guérin. (2017). Improved production yield, processing using cassette-based module and specific activity of Zirconium-89. Journée scientifique CANCER - INFLAMMATION – DOULEUR. (Published).
  • A. Alnahwi*, S. Tremblay* and B. Guerin. (2017). J. Nucl. Med. Improved production yield, processing and specific activity of 89Zr. 2017 58:335. Society of Nuclear Medicine Annual Meeting, SNMMI 2017. (Published).
  • A. Alnahwi*, S. Ait-mohand*, V. Dumulon-Perreault*, and B. Guerin. (2017). N-Radiolabeling and validation of a new acyclicchelator bearing hydroxy--methyl succinamide pendant arms for Zirconium-89 radionuclide, superior performance in comparison with DFO. 2017 58:67. Society of Nuclear Medicine Annual Meeting, SNMMI 2017. (Published).
  • A. H. Alnahwi*, S. Ait-mohand*, V. Dumulon-Perreault*, B. Guérin. (2017). NA new acyclic chelator bearing -hydroxy--methyl succinamide pendant arms for Zirconium-89 radionuclide: Radiolabeling and validation. Journée scientifique CANCER - INFLAMMATION – DOULEUR. (Published).
  • S. Aït-Mohand*, V. Dumulon-Perreault*, B. Guérin. (2017). NSuperior performance of a new acyclic chelator bearing -hydrox--methyl succinamide pendant arms, 4HMSA, in comparison with DOTA and NOTA for 68Ga PET. May 1, 2017 vol. 58:671. Society of Nuclear Medicine Annual Meeting, SNMMI 2017. (Published).
  • B. Guérin, S. Aït-Mohand*, A. Alnahwi*, V. Dumulon-Perreault*. (2017). Novel Acyclic Chelatorsfor 89Zr and 68Ga. ESRR’18 – 19th European Symposium on Radiopharmacy and Radiopharmaceuticals. (Published).
  • C. Zhang, J. Pan, K.-S. Lin, J. Zeisler, B. Guerin, and F. Benard. (2017). Stabilizing truncated peptides targeting the neuropeptide Y1 receptor for cancer imaging. JNucl Med 2017 58:693. Society of Nuclear Medicine Annual Meeting, SNMMI 2017,. (Published).
  • M. Paquette*, É. Lavallée, S. Phoenix*, H. Senta, J. E. van Lier, R. Lecomte, B. Guérin, É. E. Turcotte. (2017). Successful Diagnosis ofa CT-Negative, Bone Scintigraphy-Negative and FDG-PET-Negative Metastatic Recurrence Case Using ER-Targeting 4FMFES-PET. EANM’17. (Published).
  • N. Mansour*, M. Paquette*, S. Ait-Mohand*, V. Dumulon-Perreault*, R. Lecomte, B. Guérin. (2016). : Novel RadiolabeledPeptide for PET Imaging of Prostate Cancer64Cu-DOTHA2-PEG-RM26. Oral presentation given by B. Guérin. ESRR’16 – 18th European Symposium on Radiopharmacy and Radiopharmaceuticals. (Published).
  • S. Ait-Mohand*, V. Dumulon-Perreault*, B. Guérin. (2016). A new NPY-Y1R targeting peptide for breast cancer PET imaging. Oral presentation given by Guerin. ESRR’16 – 18th European Symposium on Radiopharmacy and Radiopharmaceuticals. (Published).
  • S. Osati*, M. Paquette*, S. Beaudoin*, H. Ali*, F. Marques, B. Guérin, J.V. Leyton and J. E. van Lier. (2016). BODIPY-estradiol conjugates as multi-modality tumor imaging agents. ESRR’16 – 18th European Symposium on Radiopharmacy and Radiopharmaceuticals. (Published).
  • M Paquette*, S Beaudoin*, L Fafard-Couture, L-G Vilera-Perez, N Ekindi-Ndongo, A Lopez, R Lecomte, R Sabbagh, B Guerin, and J Leyton. (2016). ChAcNLS-A14, a novel antibody-conjugate PET tracer for targeting human IL-5R?-positive muscle invasive bladder cancer. J Nucl Med 2016, 57:52. Society of Nuclear Medicine Annual Meeting, SNMMI 2016. (Published).
  • L. Fafard-Couture, S. Osati*, S. Beaudoin*, V. Dumoulon-Perreault*, R. Lebel, M. Lepage, B. Guerin, J. van Lier, and J. Leyton. (2016). ChAcNLS-A14-B105, a novel photodynamic imaging agent for detection of muscle invasive bladder cancer. AACR Annual Meeting 2016. (Published).
  • S. Ait-Mohand*, V. Dumulon-Perreault*, F. Benard B. Guérin. (2016). Design optimization of a new 64Cu/NOTA truncated NPY analog with improved stability and Y1 affinity, the first step toward successful breast cancer PET Imaging. J Nucl Med, 2016, 57:1076. Society of Nuclear Medicine Annual Meeting, SNMMI 2016,. (Published).
  • C Zhang, J Pan, K-S Lin, I Dude, J Lau, H Merkens, S Jenni, B Guerin, and F Benard. (2016). Improved 68Ga-labelled truncated peptides targeting the neuropeptide Y1 receptor for cancer imaging by positron emission tomography. Society of Nuclear Medicine Annual Meeting, SNMMI 2016. (Published).
  • DP Blondin, B Guérin, EE Turcotte, D Richard, F Haman , AC Carpentier. (2016). Inhibition of intracellular triglyceride lipolysis significantly impairs BAT oxidative metabolism in humans. Keystone Symposia on Molecular and Cellular Biology. (Published).
  • M Paquette*, S Beaudoin*, L Fafard-Couture, A Lopez, R Lecomte, B Guerin, and J Leyton. (2016). Novel 64Cu-labeled antibody-conjugates designed to evade the endosomal-lysosomal pathway for increased intracellular radio-accumulation in target IL-5R?-positive muscle invasive bladder cancer cells. J Nucl Med 2016, 57:391. Society of Nuclear Medicine Annual Meeting, SNMMI 2016. (Published).
  • G Tremblay*, S Aït-Mohand*, R Ouellet* and B Guérin. (2016). Novel syntheticapproach for one-pot F-18 labeling of unprotected peptides for PET imaging. Journée Phare 2016, Congrès québécois en sciences de la santé. (Published).
  • M Paquette*, E Lavallee, S Phoenix, H Senta, B Guerin, J van Lier, R Lecomte, and E Turcotte. (2016). Ongoing Phase II Trial Comparing 4FMFES and FES Estrogen-Receptor PET Tracers in Breast CancerPatients: an Update. J Nucl Med 2016, 57:567. Society of Nuclear Medicine Annual Meeting, SNMMI 2016,. (Published).
  • A Pirisedigh*, Y Dory, L Gendron, B Guerin. (2016). Preparation and evaluation of a series of 19F-enkephalin analogues; the first step in the design of potent and selective 18F-labeled PET tracers for delta opioid receptor imaging. 252 nd ACS National Meeting. (Published).
  • F Gobeil Jr, M Savard, V Dumulon-Perreault*, C Dubuc*, E Croteau, and B Guerin. (2016). Theranostic potential of a new [64Cu]-radiolabeled R-954 conjugate for kinin B1R positive tumors. J Nucl Med 2016, 57:1164. Society of Nuclear Medicine Annual Meeting, SNMMI 2016. (Published).
  • G Tremblay*, S Aït-Mohand*, R Ouellet* and B Guérin. (2015). .Novel synthetic approach for one-pot F-18 labeling of unprotected peptides for PET imaging. 26th Québec/Ontario Mini-Symposium in Bioorganic and Organic Chemistry. (Published).
  • M. Paquette*, S. Beaudoin*, L. Couture-Fafard, L.Vilera, N, Ekindy, R. Sabbagh, R. Lecomte, B. Guérin, A. Lopez, and J. V. Leyton. (2015). A Novel Antibody-Conjugate Design To Exploit Internalization and Trafficking of Interleukin-5 Receptor ?-subunit– Implications For More Effective Tumor Targeting. CRCL 2015 (2nd International Symposium of the Cancer Research Center of Lyon). (Accepted).
  • S. Osati*, H. Ali*, M. Paquette*, B.Guérin and J. E. van Lier. (2015). BODIPY- Estradiol Conjugates for Fluorescence Imaging of Breast Cancer. European Society for Photobiology 2015 Congress. (Accepted).
  • N. Mansour*, M. Paquette*, S. Ait-Mohand*, B. Guerin. (2015). Biological evaluation of 64Cu-radiolabeled gastrin-releasing peptide receptors antagonist conjugated to DOTHA2 a new bifunctional chelator bearing hydroxamic acid arms. 2nd International Conference on Prostate Cancer and Treatment. (Accepted).
  • A. Pirisedigh*, Y. Dory, L. Gendron, B. Guérin. (2015). Design, Synthesis and Evaluation of Selective 19F-Enkephalin Analogs; A First Step in the Development of PET Tracers for DOP Imaging. 26th Québec/Ontario Mini-Symposium in Bioorganic and Organic Chemistry. (Accepted).
  • É. Croteau*, C.-A. Castellano, S. Tremblay, B. Guérin, L. De Beaumont, S.C. Cunnane. (2015). Imagerie cérébrale de l’activité métabolique et de la protéine ?-amyloïde chez d’anciens athlètes universitaires ayant subi un traumatisme craniocérébral léger. Journée scientifique 2015. (Published).
  • S. V. Selivanova*, É. Lavallée, O. Sarrihni, B. Guérin, É. Turcotte, R. Lecomte. (2015). Investigation of Image Quality with Sodium Pertechnetate 99mTc Produced by Cyclotron. EANM'15 - Annual Congress of the European Association of Nuclear Medicine. (Published).
  • C. Zhang, J. Pan, J. Lau, N. Colpo, S. Jenni, S. Park, B. Guerin, K.Lin, F. Bénard. (2015). In vitro and in vivo evaluation of a novel 68Ga-labeled BVD15 analogue for neuropeptide Y1 receptor imaging with positron emission tomography. WMIC 2015, 8th Annual World Molecular Imaging Congress. (Published).
  • F. Gobeil jr, M. Savard, C. Dubuc, J. Côté,, V. Dumulon-Perreault*, M. Paquette*, É.Croteau, S. Ait-Mohand*, B. Guérin. (2015). Novel Kinin-Based Analogues as Potential BBB-Penetration Enhancers for Delivery of Chemotherapy and as New Theranostic Agents for Imaging and Treatment of Malignant Brain Cancer. Kinin 2015 - International Meeting on Kinin System and Peptide Receptors. (Published).
  • G. Tremblay*, S. Aït-Mohand*, R. Ouellet*, B. Guérin. (2015). Novel Synthetic approach for one-pot 18F radiolabeling of unprotected peptides for PET imaging. Journée scientifique 2015. (Accepted).
  • G. Tremblay*, S. Ait-Mohand*, R. Ouellet, and B. Guerin. (2015). Novel synthetic approachfor one-pot F-18 labeling of unprotected peptides for PET imaging. J NuclMed 2015 56:221. Society of Nuclear Medicine Annual Meeting, SNMMI 2015,. (Accepted).
  • F Couture, K Ly, C Levesque, A Kwiatkowska, R Desjardins, B Guérin, R Day. (2015). PACE4-dependent cellular uptake and retention of the Multi-Leucine peptide inhibitor into cancer cells. AACR Annual Meeting 2015. (Published).
  • S. Selivanova*, É. Lavallée, H. Senta, L. Caouette, A. Zyuzin, A. McEwan, J. van Lier, B. Guerin, R. Lecomte, and É. Turcotte. (2015). Phase I clinical trial using sodium pertechnetate 99mTc produced by medium-energy cyclotron. J Nucl Med 2015 56:475. Society of Nuclear Medicine Annual Meeting, SNMMI 2015. (Accepted).
  • M. Paquette*, L. Fafard-Couture, S. Beaudoin, B. Guérin, J. Leyton. (2015). Évaluation préliminaire in vivo par imagerie TEP d'un anticorps-NLS-acide cholique marqué au cuivre-64 et ciblant IL5-R? dans un modèle de cancer de la vessie. Journée scientifique 2015. (Accepted).
  • A. Rondeau*, S. Beaudoin*, B. Guerin, M. Bentourkia, and J. V. Leyton. (2014). A novel delivery system for enhanced cellular accumulation inside IL-3Ra+ leukemic stem cells using functionalized 7G3 antibody. Symposium Imaginez l'imagerie. (Accepted).
  • S. V. Selivanova, É. Lavallée, H. Senta, J. Sader, E.J. van Lier, A. Zyuzin, J. E. van Lier, B. Guérin, R. Lecomte, É. Turcotte. (2014). Clinical quality sodium pertechnetate Tc-99m is reached with cyclotron at 24 MeV. EANM Congress 2014. (Published).
  • G. Tremblay*, S. Ait-Mohand*, C. Denis*, M. Paquette* and B. Guérin. (2014). DOTHA2 and NOTHA2, New Chelates for Highly Efficient Cu-64 Radiolabeling. Journée Phare 2014. (Accepted).
  • G. Tremblay*, S. Ait-Mohand*, C. Denis*, M. Paquette* and B. Guérin. (2014). DOTHA2 and NOTHA2, New Chelates for Highly Efficient Cu-64 Radiolabeling. Symposium Imaginez l'imagerie. (Published).
  • S. Ait-Mohand*, C. Denis*, G. Tremblay*, M. Paquette* and B. Guérin. (2014). DOTHA2 and NOTHA2—New Chelates for Highly Efficient Cu-64 Radiolabeling. TERACHEM 2014 Symposium. (Accepted).
  • Blanchette M, Gascon S, Tremblay S*, Tremblay L, Guérin B, Lepage M, Lecomte R, Fortin D. (2014). Does Osmotic blood-brain Barrier Disruption allows efflux pump substrates delivery to the tumor and CNS?. 19th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology. (Submitted).
  • N. Mansour*, V. Dumulon-Perreault*, L. Matei*, S. Ait-Mohand*, B. Guerin. (2014). Impact des espaceurs sur la biodistribution in vivo d'antagonistes de GRPR marqués au 64Cu/NOTA. 56e réunion annuelle du CRCQ. (Accepted).
  • S. V. Selivanova*, E. Lavallée, J. Sader, E. J. van Lier, A. Zyuzin, J. E. van Lier, É. Turcotte, R. Lecomte, B. Guérin. (2014). Isotopic purity of 100Mo targetis paramount for cyclotron production of clinical quality 99mTc. American Chemical Society Meeting. (Accepted).
  • C. Denis*, S. Ait-Mohand*, N. Mansour*, G. Tremblay*, B. Guérin. (2014). Le 64Cu , un radionucléide à visée théranostique pour le cancer. Symposium de la recherche sur le cancer. (Published).
  • F.Couture*, C. Levesque, V. Dumulon-Perreault, S. Ait-Mohand*, F. D’Anjou, B. Guérin, R. Day. (2014). Molecular imaging of prostate cancer using an engineered PACE4 radiolabelled peptide inhibitor. Symposium Imaginez l'imagerie. (Accepted).
  • A.Zyuzin, J. Sader, E. Jenei, S. Tremblay*, P. Thibault, B. Guérin. (2014). New Targetry Possibilities from the TR-24. 15Th Internanional Workshop on targetry and target chemistry. 15Th Internanional Workshop on targetry and target chemistry. (Accepted).
  • G. Tremblay*, S. Ait-Mohand* et B. Guérin. (2014). Novel synthetic approaches to 18F radiolabeling of gastrin receptor targeting peptides for breast and prostate cancer PET imaging. Symposium de la recherche sur le cancer. (Published).
  • G. Tremblay*, S. Ait-Mohand* et B. Guérin. (2014). Novel synthetic approaches to 18F radiolabeling of gastrin receptor targeting peptides for breast and prostate cancer PET imaging. Journée scientifique de la faculté de médecine et des sciences de la santé. (Published).
  • G. Tremblay*, S. Ait-Mohand* et B. Guérin. (2014). Novel synthetic approaches to 18F radiolabeling of gastrin receptor targeting peptides for breast and prostate cancer PET imaging. 56e réunion annuelle du CRCQ. (Accepted).
  • C. Levesque, F. Couture, S. Ait-Mohand*, B. Guérin, R. Day. (2014). PACE4 Inhibitors and Their Peptidomimetic Analogs Block Prostate Cancer Tumor Progression Through Quiescence Induction, Increased Apoptosis and Impaired Neovascularisation. Gordon Research Conference on Protein Processing, Trafficking and Secretions. (Published).
  • S. Ait-Mohand*, C. Denis*, G. Tremblay*, M. Paquette*, B. Guérin. (2014). Synthesis and Evaluation of DOTHA2 and NOTHA2 Bifunctional Chelators Bearing N-Methyl-Hydroxamic Acid Arms. 97th Canadian Chemistry Conference and Exhibition. (Published).
  • G. Tremblay*, S. Ait-Mohand*, C. Denis*, B. Guérin. (2014). Synthesis and evaluation of DOTHA2 and NODHA2 bifunctional chelators bearing methyl-hydroxamic acid arms. Society of Nuclear Medicine Annual Meeting. (Published).
  • V. Dumulon-Perreault*, S. Ait-Mohand*, L. Matei*,P. Fournier*, J.F Beaudoin, F. Benard,B. Guerin. (2013). 64Cu-labeled GRPR agonist and antagonist in prostate cancer PET imaging. SNMMI 2013, Vancouver, BC, Canada, June 8-12, 2013. (Published).
  • S. V. Selivanova*, L. Matei*, V. Dumulon-Perreault*, J. Rousseau, É. Turcotte, B. Guérin R. Lecomte. (2013). 99mTc-Pertechnetate Production Using a Cyclotron: Considerations for Patient Dosimetry and Personnel Radiation Protection. CRPA Conference, Sherbrooke, Quebec, May 26 – 30. (Published).
  • S. Selivanova*, L. Matei*, R. Lecomte, J. van Lier, E. Turcotte, J. Sader, E. van Lier, A. Zyuzin, University of Alberta, B. Guérin. (2013). 99mTc-Pertechnetate production using a medium-energy cyclotron. SNMMI 2013, Vancouver, BC, Canada, June 8-12, 2013. (Published).
  • S. Selivanova*, L. Matei*, V. Dumulon-Perreault*, J. Rousseau, J. Sader, E. J. van Lier, A. Zyuzin, J. E. van Lier, É. Turcotte, R. Lecomte, B. Guérin. (2013). 99mTc-pertechnetate manufacturing using a medium-energy cyclotron: from target irradiation to quality control. Radiometals 2013, Santa Rosa, California, USA, June 13-16, 2013. (Published).
  • J. Fortin*, M.-O. Benoit Biancamano, B. Guérin. (2013). Caractérisation du rôle de l'amyline (IAPP) dans le diabète de type 2 et les tumeurs des îlots pancréatiques. Congrès de l’ACFAS, Université Laval, Qc, Canada, May 7, 2013. (Accepted).
  • A. Zyuzin, E. van Lier, J. Sader, B. Guerin, R. Lecomte, M. Toussaint, E Turcotte, D Abrams, A McEwan, John Wilson, S. McQuarrie, S. Jakeway. (2013). Cyclotron production of 99mTc in Canada. 245th ACS National Meeting, New Orleans, LA. (Published).
  • M. Pourghiasian, J. A.Inkster, N. Hundal, B. Guerin, T. Ruth, K.S. Lin, F. Benard. (2013). PEGylated F-18 labeled bombesin derivatives for improved GRP receptor imaging in prostate cancer. SNMMI 2013, Vancouver, BC, Canada, June 8-12, 2013. (Published).
  • P. Fournier*, V. Dumulon-Perreault*, S. Ait-Mohand*, R. Langlois, F. Benard, R. Lecomte, B. Guerin. (2012). Comparative study of GRPR-targeting monomer and dimers for prostate cancer PET imaging. SNM Annual Meeting, Miami, Fl, June 9-13, 2012.J Nucl Med. 2012; 53 (Supplement 1): 1646. (Published).
  • E. Turcotte, M. Paquette*, E. Lavallée, R. Langlois, S. Dubreuil, H. Senta, R. Lecomte, B. Guerin, F. Benard, J. Van Lier. (2012). Comparison of 4FMFES-PET with FES-PET in a phase II trial to detect estrogen receptor-positive breast cancer: Preliminary results. SNM Annual Meeting, Miami, Fl, June 9-13, 2012. J Nucl Med. 2012; 53 (Supplement 1):281. (Published).
  • P. Fournier*, V. Dumulon-Perreault*, S. Ait-Mohand*, R. Lecomte, F. Bénard and B. Guérin. (2012). Labelling of a novel peptide for GRPR breast and prostate tumor PET imaging with 64Cu and 68Ga, an in vitro and in vivo comparative study. World Molecular Imaging Congress (WMIC 2012). (Published).
  • V. Dumulon-Perreault*, E. Croteau, S. Ait-Mohand*, R. Ouellet*, J. Rousseau, J.-F. Beaudoin, J.-F. Gagnon, R. Lecomte, E. Turcotte, B. Guerin. (2012). PET imaging of pulmonary embolism with 18F-Fluorogas and 64Cu-MAA. SNM Annual Meeting, Miami, Fl, June 9-13, 2012, J Nucl Med. 2012; 53 (Supplement 1):487. (Published).
  • Dumulon-Perreault, V.*; Croteau, E.; Ait-Mohand, S.*; Ouellet, R.*; Rousseau, J. A.; Beaudoin, J.-F.; Lecomte, R.; Turcotte, E. E.; Guerin, B. (2012). PET imaging of pulmonary embolism with 18F-Fluorogas and 64Cu-MAA. World Molecular Imaging Congress (WMIC 2012). (Published).
  • N. Cauchon, E. Ranyuk*, B. Guérin, K. Klarskov, J. E. van Lier. (2012). Phthalocyanine-Peptide Conjugates: Receptor-Targeted Bi-Functional Agents for Imaging and Photodynamic Therapy. 36th meeting of the American Society for Photobiology (ASP). (Published).
  • M. Paquette*; É. Lavallée; R. Langlois; E. Croteau; B. Guerin; F. Benard; J.E. van Lier; R. Lecomte; E.E. Turcotte. (2012). Preliminary Results of a Phase II Trial Comparing 4FMFES to FES in PET imaging of Breast Cancer Patients. Journal of Nuclear Medicine, (Published).
  • A. Radulska, S. Ait-Mohand*, V. Dumulon-Perreault*, R. Lebel, R. Zriba, B. Guérin, W.A. Neugebauer, M. Lepage. (2012). Stability studies of peptides specific for MMP-2 as potential PET probes. 22ND European Peptide Symposium. (Published).
  • J. van Lier, E. Ranyuk*, N. Cauchon, H. Ali*, R. Lecomte, B. Guérin. (2012). Synthesis of Cu-64 labelled phthalocyanine-based photosensitizers to generate PET-derived biodistribution patterns for structure-activity relationships. 16th European Symposium on Radiopharmacy and Radiopharmaceuticals April 26-29, 2012 Nantes, France J. Nucl. ed. Mol. Im, 2012;.56, Suppl 1-2, 69-70. (Published).
  • R.Day, F. D’Anjou, F. Couture, C. Levesque, A. Kwaitkowska, S. Routhier, R. Desjardins, B. Guérin, Al. Doueik, M. Carmel, and R. Sabbagh. (2012). Targeting the Proprotein Convertases in Prostate Cancer. 67th Annual Meeting of the Canadian Urological Association - CUA 2012. (Published).
  • A. McEwan, S. McQuarrie, D. Abrams, K. Gagnon, J Wilson, E. Turcotte, B.Guerin, R.Lecomte. (2012). Technetium-99m (Tc-99m) pertechnetate (TcO4) imaging with cyclotron produced Tc-99m compared with generator Tc-99m. SNM Annual Meeting, Miami, Fl, June 9-13, 2012. J Nucl Med. 2012; 53 (Supplement 1):487. (Published).
  • Pourghiasian, M.; Inkster, J.; Hundal, N.; Mesak, F.; Guerin, B.; Ait-Mohand, S.; Ruth,T.; Adam, M.; Lin, K.-S.; Benard, F. (2011). 18F-BVD-15 for NPY Y1 receptor imaging in breast cancer and neuroblastoma models by PET. SNM Annual Meeting, San Antonio, Texas, June 4-8, 2011. J. Nucl Med. 2011; 52 (Supplement 1):1682. (Published).
  • B. Guérin, P. Fournier, V. Dumulon-Perreault, S. Ait-Mohand, R. Lecomte, F. Bénard. (2011). 64Cu/NOTA-[D-Tyr6,?Ala11,Thi13,Nle14]BBN(6-14) monomers and dimers for breast and prostate cancer PET imaging. 19th International Symposium on Radiopharmaceutical Sciences. Amsterdam, The Netherlands, Aug.28-Sept.02, 2011. J Label Compd Radiopharm 2011; 54: S232. (Published).
  • J.A.H.Inkster, K. Liu, P. Schaffer, B. Guerin, T. Ruth, T. Storr. (2011). Assessing the potential of sulfonyl fluorides as 18F-bearing prosthetic molecules. 19th International Symposium on Radiopharmaceutical Sciences. Amsterdam, The Netherlands, Aug.28-Sept.02, 2011. J Label Compd Radiopharm 2011; 54: S75. (Published).
  • Dumulon-Perreault, V.; Ait-Mohand, S.; Fournier, P.; Kiefer, G.; Jurek, P.; Ferreira, C.; Guerin, B. (2011). Bifunctional chelates for 64Cu radiolabelling of BBN peptides for PET imaging, a comparative study. SNM Annual Meeting, San Antonio, Texas, June 4-8, 2011. J. Nucl Med. 2011; 52 (Supplement 1):471. (Published).
  • A.Zyuzin, E. J. van Lier, K. Gagnon, D. Abrams, J Wilson, S. McQuarrie, R. Lecomte, J.E. van Lier, B. Guérin. (2011). Commercializing cyclotron production of 99mTc in Canada: the Canadian ACS-ES approach. 19th International Symposium on Radiopharmaceutical Sciences. Amsterdam, The Netherlands, Aug.28-Sept.02, 2011. J Label Compd Radiopharm 2011; 54: S341. (Published).
  • Fournier, P.; Dumulon-Perreault, V.; Ait-Mohand, S.; Bénard, F.; Lecomte, R.; Guerin, B. (2011). Comparative study of 64Cu/NOTA-[D-Tyr6, ?Ala11, Thi13, Nle14]BBN(6-14) monomer and dimer for breast cancer PET imaging. SNM Annual Meeting, San Antonio, Texas, June 4-8, 2011. J. Nucl Med. 2011; 52 (Supplement 1):1575. (Published).
  • Ranyuk, E.; Cauchon, N.; Ali, H.; Gosselin, S.; Guérin, B.; van Lier, J. (2011). Copper-64 Labeling of phthalocyanine based- Photosensitizers for Positron Emission Tomography. Radiopharmaceuticals and Imaging posters, 94th Canadian Chemistry Conference and Exhibition, Palais des Congrès, Montréal, Qc, Canada, June 5-9, 2011. (Published).
  • Pourghiasian, M.; Inkster, J.; Hundal, N.; Mesak, F.; Guerin, B.; Ait-Mohand, S.; Ruth,T.; Adam, M.; Lin, K.-S.; Benard, F. (2011). Improved tumor targeting of F-18 bombesin analogs labeled by click chemistry is achieved by addition of a PEG side chain. SNM Annual Meeting, San Antonio, Texas, June 4-8, 2011. J. Nucl Med. 2011; 52 (Supplement 1):1579. (Published).
  • Fournier P., A.; Dumulon-Perreault, V.; Ait-Mohand, S.; Bénard, F.; Lecomte, R.; Guérin, B. (2011). Le DOTA-Aoc-BBN(6-14) marqué au 64Cu et 68Ga pour la détection du cancer du sein par imagerie TEP. Congrès de l’ACFAS, Université de Sherbrooke, Sherbrooke, Qc, Canada, May 6-13, 2011. (Published).
  • Ait-Mohand, S.; Ali, H.; Ranyuk, E.; Gosselin, S.; van Lier, J.; Guérin, B. (2011). Les peptides couplés aux phthalocyanines via des réactions de couplage croisé catalisées au palladium pour l’imagerie bimodale de fluorescence et TEP. Congrès de l’ACFAS, Université de Sherbrooke, Sherbrooke, Qc, Canada, May 6-13, 2011. (Published).
  • Rémillard, A.; Ait-Mohand, S.;Bernatchez, G.; Guérin, B. (2011). Nouveaux radiotraceurs peptidiques analogues de la bradykinine pour améliorer le diagnostic du cancer du sein et de la prostate par tomographie d'émission par positrons. 40e Édition de la Journée Scientifique de Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Qc, Canada, March 22-23 2011. [Prix FRSQ (CRC Étienne-Le Bel) -. (Published).
  • Fournier, P.; Dumulon-Perreault, V.; Ait-Mohand, S.; Lecomte, R.; Bénard, F.; Guerin, B. (2011). Novel radiolabeled peptides for breast and prostate tumor PET imaging: 64Cu/ and 68Ga/NOTA-PEG-BBN(6-14). SNM Annual Meeting, San Antonio, Texas, June 4-8, 2011. J. Nucl Med. 2011; 52 (Supplement 1):470. (Published).
  • B. Guérin, V. Dumulon-Perreault, E. Croteau, S. Ait-Mohand, R. Ouellet, J. Rousseau, R. Lecomte, E. Turcotte. (2011). PET imaging of pulmonary embolism with 18F-Fluorogas and 64Cu-MAA. 19th International Symposium on Radiopharmaceutical Sciences. Amsterdam, The Netherlands, Aug.28-Sept.02, 2011. J Label Compd Radiopharm 2011; 54: S144. (Published).
  • E. Ranyuk, N. Cauchon, H. Ali, B. Guérin, J.E. van Lier. (2011). Preparation of Cu-64 labeled analogs of phthalocyanine-based photosensitizers for positron emission tomography (PET) imaging and in vivo studies of phthalocyanine biodistribution. 19th International Symposium on Radiopharmaceutical Sciences. Amsterdam, The Netherlands, Aug.28-Sept.02, 2011. J Label Compd Radiopharm 2011; 54: S129. (Published).
  • Fournier P., A.; Ait-Mohand, S.; Dumulon-Perreault, V.; Guérin, B. (2011). Étude comparative in vitro des dérivés du BBN(6-14) radiomarqués au 64Cu et 68Ga pour la détection du cancer du sein par imagerie TEP. 40e Édition de la Journée Scientifique de Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Qc, Canada, March 22-23 2011. (Published).
  • Guérin, B.; Zyuzin, A.; Tremblay, S.; van Lier, E.; Rodrigue, S.; Rousseau, J.; Dumulon-Perreault, V.; Lecomte, R; van Lier, J. E. (2010). Comparing cyclotron- with generator-produced Tc-99m. International Symposium on Technetium and other Radiometals in Chemistry and Medicine, Bressanone (BZ), Italy. (Published).
  • A. Zyuzin, B. Guérin, E.J. van Lier, S. Tremblay, S. Rodrigue, J.A. Rousseau, V. Dumulon-Perreault, R. Lecomte, J.E. van Lier. (2010). Cyclotron production of 99mTc. 13th International Workshop on Targetry and Target Chemistry, Roskilde, Denmark. (Published).
  • Guérin, B.; Zyuzin, A.; Tremblay, S.; van Lier, E.; Rodrigue, S.; Rousseau, J.; Dumulon-Perreault, V.; Lecomte, R; van Lier, J. E. (2010). Direct production of 99mTc with a medical cyclotron?. Pacifichem 2010, Honolulu, Hawaï, USA,. (Published).
  • B. Guérin, A. Zyuzin, S. Tremblay, E.J. van Lier, S. Rodrigue, J.A. Rousseau, V. Dumulon-Perreault, R. Lecomte, J.E. van Lier. (2010). Direct production of 99mTc with a medical cyclotron?. Society of Nuclear Medicine 57th Annual Meeting, Salt Lake City, Utah Inclusion in the “high-lights” lecture. (Published).
  • Labbé SM, Ouellet R, van Lier JE, Guérin B, Lecomte R, Carpentier A. (2010). Impact des gras alimentaires dans le developpement de la lipotoxicite des tissus non-adipeux. 11e réunion annuelle de la SQLNM, Prix de la meilleure présentation poster au niveau doctoral. (Published).
  • P Fournier, S Ait-Mohand, V Dumulon-Perreault et B Guérin. (2010). In vitro comparative study of DOTA- and NOTA-BBN(6-14) radiolabelled with 64Cu for breast cancer PET imaging. Colloque Uppsala /Sherbrooke, Université de Sherbrooke, Sherbrooke, Qc, Canada. (Published).
  • Turashvili G, Aparicio S, Guérin B, Watson P, Bénard F. (2010). Overexpression of peptide receptors as target for PET or SPECT radiopharmaceuticals: a tissue microarray study (TMA). Society of Nuclear Medicine 57th Annual Meeting, Salt Lake City, Utah. (Published).
  • P Fournier, S Ait-Mohand, V Dumulon-Perreault et B Guérin. (2010). Peptides radiomarqués au Cuivre-64 et au Gallium-68 pour la détection du cancer du sein par tomographie d’émission par positron. 39e Édition de la Journée Scientifique de Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Qc, Canada Prix Jean-Marie Beauregard. (Published).
  • Guérin, B.; Ali, H.; Ait-Mohand, S.; Gosselin, S.; van Lier, J. E. (2010). Phthalocyanine-functionalized peptides via palladium-catalyzed cross-coupling reactions. Pacifichem 2010, Honolulu, Hawaï, USA,. (Published).
  • E.J. van Lier, J. Garret, B. Guérin, S. Rodrigue, J.E. van Lier, S. McQuarrie, J. Wilson, K. Gagnon, M.S. Kovacs, J. Burbee, A. Zyuzin,. (2010). Targets for Cyclotron Production of Tc-99m. 13th International Workshop on Targetry and Target Chemistry, Roskilde, Denmark. (Published).
  • Fournier,P.; Ait-Mohand, S.; Dumulon-Perreault, V.; Guérin, B. (2010). Étude compartive in vitro de derivés du BBN(6-14) radio marqués au 64Cu et au 68Ga pour la détection du cancer du sein par imagerie TEP. Journée Phare 2010 de l’Université de Sherbrooke , Sherbrooke, QC, Canada. (Published).
  • M. Paquette, E. Lavallée, S. Phoenix, H. Senta, R. Lecomte, B. Guerin, E. Turcotte. 4FMFES-PET in ER+ lobular breast cancer: revealing what FDG-PET could not. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:1227.
  • M. Paquette, S. Phoenix, R. Lecomte, B. Guerin, E. Turcotte. 4FMFES and FDG-PET of a ER+ uterine cancer mousexenograft model. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:1418.
  • S. Beaudoin, S, Tremblay, S. Ait-mohand, J. Leyton, B. Guerin. A new PET imaging agent for monitoring HER2 status using Trastuzumabantibody conjugated with a novel 89Zr-chelator. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:1009.
  • J.-M. Beauregard, P. Cadieux, F.-A. Buteau, A. Beaulieu, B. Guérin, E. Turcotte. Development ofTheranostic Response Criteria In Solid Tumors (THERCIST) and tumor burdenquantification methods for 68Ga-PET/CT and 177Lu-QSPECT/CT. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:626.
  • L. Dery, G. Charette, L. Sanche, B. Guérin. D. Fortin. 2nd price, poster presentation to L. Dery. Gliotrap: un nouveau traitement contre les tumeurscérébrales primaires. Symposium de la recherche sur le cancer.
  • E. Croteau, E. Rousseau, P. Prud'Homme, S. Cunnane, V. Dumulon-Perreault, M. Archambault, O. Sarrhini, M.-A. Richard, S. Tremblay, B. Guerin, R. Lecomte. Heart ketone uptakereserve in diabetic ZDF rats with an acute ketone ester supplementation: a [11C]-acetoacetaterest-stress study. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:36.
  • M. Khosravifarsani, S. Ait-Mohand, L. Sanche, B. Guérin. In-vitro cytotoxiceffect of 64Cu/NOTA-terpyridine platinum complex, as a novel chemoradiationtherapy (CRT) agent. Symposium de la recherche sur le cancer.
  • M. Khosravifarsani, S. Ait-mohand, L. Sanche, B. Guérin. In-vitro cytotoxic effect of 64Cu/NOTA-terpyridineplatinum conjugate, as a novel theranostic agent. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:1615.
  • A. Alnahwi, S. Tremblay, S. Ait-Mohand, J.-F. Beaudoin, B. Guerin. Large-scale routineproduction of 68Ga using 68Zn-pressed target. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:634.
  • S. Kanh Ali, S. Ait-Mohand, V. Dumulon-Perreault, B. Guérin. Best poster presentation to S. Kanh Ali. Le 68Ga-4HMSA, un traceur TEP pourl’imagerie de l’inflammation ?. Symposium de la recherche sur le cancer.
  • J.-M. Beauregard, F.-A. Buteau, A. Beaulieu, F. Arsenault, M. Del Prete, N. Lafrenière, E. Turcotte, B. Guérin. Planning ofpersonalized 177Lu-octreotate PRRT with 68Ga-octreotate-PET/CT:the tumor sink effect and the renal uptake as predictors of renal dosimetry. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:628.
  • J.-F. Beaudoin, S. Tremblay, A. Alnahwi, B. Guerin. Target carrier anddissolution system for facilitating end-to-end in-vault cyclotron production ofradiometals in large quantities. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:1162.
  • V. Dumulon-Perreault, S. Ait-mohand, S. Tremblay, E. Rousseau, E. Turcotte, J.-M. Beauregard, F. Pouliot, B. Guerin. Validation of 68Ga-4HMSA-PSMA,a novel PSMA radioligand for PET Imaging of Prostate Cancer. Society of Nuclear Medicine Annual Meeting, SNMMI 2018 J Nucl Med 2019 60:1044.
  • V. Dumulon-Perreault, S. Tremblay, J.-F, Rousseau, S. Ait-Mohand, E. Rousseau, E. Turcotte, J.-M. Beauregard, F. Pouliot, B. Guerin. Validation of [68Ga]-Ga-DOTA-TATE using 68Gaproduced by cyclotron. Society of Nuclear Medicine Annual Meeting, SNMMI 2018.

Propriétés intellectuelles

Patents

  • (2006). New peptidic and peptidoid bradykinin b1 receptor antagonists and uses thereof. WO 2006017938 A1. Canada. (Granted/Issued).
  • CARRIER FOR IRRADIATED TARGET AND DISSOLUTION SYSTEM FOR PRODUCING SOLUTION OF SAME. US 62/833,058. Canada. (Pending).
  • NOVEL KININ-BASED THERANOSTIC PROBES FOR SOLID CANCERS (AS BRAIN TUMORS) AND USES THEREOF. PCT/CA2016/050732. Canada. (Pending).
  • PROCESSES AND SYSTEMS FOR PRODUCING AND/OR PURIFYING GALLIUM-68. 62/777,994 USPR. Canada. (Pending).
  • PROCESSES FOR OBTAINING TECHNETIUM-99M AND/OR MOLYBDENUM(VI) OXIDE. 05202424-36CA. Canada. (Pending).
  • RADIOLABELLED PACE4 INHIBITOR FOR MOLECULAR IMAGING AND TARGETED THERAPY OF CANCER. Canada. (Pending).

Autres contributions

Gestion d'évènements

  • Organizing Committee, Local. (2012). 10th International NPY-PYY-PP meeting. (Conference).

Activités de collaboration internationale

  • Expert in radiochemistry. (2018). Austria. 2nd Research Coordination Meeting on Copper-64Radiopharmaceuticals for Theranostic Applications 7-11 May 2018, IAEAHeadquarters Vienna, Austria.
  • Expert in radiochemistry,. (2018). Austria. Consultants’ Meeting on Formulationof an IAEA TECDOC on “Ga-68 Cyclotron Production” 26-29 March 2018, IAEAHeadquarters.
  • Expert in radiochemistry. (2012). Saudi Arabia. Presentations given at Riyadh and Jeddah on the feasibility ofcyclotron-based production of medical 99mTc, as an alternativeto nuclear-reactor based procedures.

Présentations

  • (2019). Cyclotron Production of Zr-89 and Ga-68 Using Pressed Targets. TRIUMF Science week. Vancouver. Canada.
  • (2019). ONCOPOLE : Optimiser les soins des patients atteints du cancer de la prostate résistant à la castration en utilisant une stratégie de triple traceur en imagerie moléculaire et en radiothérapie ciblée. Symposium de la recherche sur le cancer,Sherbrooke. Canada.
  • (2019). Optimizing care for prostate cancer patients using molecular imaging and targeted radioligand therapy. 11th Scientific Day QBIN, Montreal. Canada.
  • (2019). Our experience on metallic radiopharmaceuticals Development of 68Ga-Octreotate and 68Ga-PSMA for molecular imaging using 68Ga-produced by cyclotron. CONSULTANTS’ MEETING (EVT1701715), IAEA Headquarters, Vienna. Austria.
  • (2018). 18F-labelled BODIPY-steroid conjugates as potential bimodal imaging agents. Tenth International Conference on Porphyrins & Phthalocyanines, ICPP?10. Munich, Germany.
  • (2018). Cyclotron production of 68Ga via 68Zn(p,n)68Ga reaction using pressed target. Consultants’ Meeting on Formulation of an IAEA TECDOC on “Ga-68 Cyclotron Production. Vienna, Austria.
  • (2018). New 64Cu peptides for prostate and breast cancers for PET imaging. 2nd Research Coordination Meeting on Copper-64 Radiopharmaceuticals for Theranostic Applications. Vienna, Austria.
  • (2018). Optimizing care for castration-resistant prostate cancer patients using triple-tracer molecular imaging and targeted radioligand therapy. Symposium Oncopole. Canada.
  • (2018). Outils pour l’imagerie TEP, une ouverture vers le développement de théranostiques. Lecture at UQAM's chemistry department. Canada.
  • (2018). Tools for peptide radiolabeling, Clara Benson Award Lecture. 101st Canadian Chemistry Conference and Exhibition. Edmonton, Canada.
  • Martin Savard, Veronique Dumulon-Perreault, Celena Dubuc, Samia Ait-Mohand, Fernand jr Gobeil. (2017). Theranostic potential of a new 64Cu-radiolabeled peptide conjugate for kinin B1R positive tumors. BIT’s 10th Annual World Cancer Congress, WCC 2017. Spain.
  • (2016). BODIPY-estradiol conjugates as multi-modality tumor imaging agents. Ninth International Conference on Porphyrins and Phthalocyanines (ICPP9). Nanjing, China.
  • (2015). Produire des isotopes médicaux sans réacteur nucléaire. Symposium mondial sur l’uranium. Québec, Canada.
  • Alex Zyuzin. (2015). Project for Producing Tc-99m for Medical Use. State of Molybdenum-99 Production and Utilization and Progress toward Eliminating Use of Highly Enriched Uranium. Ottawa, Canada.
  • (2013). Development of PET radioeptides to Improve Cancer Diagnostic. Radiochemistry Symposium, 96th Canadian Chemistry Conference and Exhibition,. Québec, Canada.
  • (2012). Radiolabelled NPY peptides to improve cancer diagnosis by PET. 10th International NPY-PYY-PP meeting. Canada, Canada.
  • (2012). TR-24 Canadian experience. Invitation of the Saudi Arabian National Guard. Riyadh, Saudi Arabia, Saudi Arabia.
  • (2011). Optimization and Biological Evaluation of Radiolabelled Peptides as Diagnostic Tools for PET Imaging. Peptide Science Symposium, 94th Canadian Chemistry Conference and Exhibition. Montréal, Canada.
  • (2011). Radiolabelled Peptides to Improve Cancer Diagnostic by Positron Emission Tomography. Radiopharmaceuticals and Imaging Symposium, 94th Canadian Chemistry Conference and Exhibition. Montréal, Canada.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.