Rivard, Nathalie

Vice-doyenne, Faculté de médecine et des sciences de la santé

Coordonnées

Courriel


819-821-8000, poste 75211


Site Web

Diplômes

(1997) Postdoctorat (Stage post-doctoral). Université de Nice.

(1993) Doctorat (Philosophiae Doctor, Ph.D.). Université de Sherbrooke.

(1989) Baccalauréat (Bachelière ès sciences, B.Sc.). Université de Sherbrooke.

Titres de compétence

(2017) Cancer Axis director. Centre Hospitalier Univ. de Sherbrooke.

(2017) Editorial board de Médecine Sciences.

Editorial Board Member of World J Gastrointestinal and Pathophysiology.

Editorial Board of Gastrointestinal Cancer: Targets and Therapy Gastrointestinal Cancer: Targets and Therapy.

Editorial board of International Journal of Oncology.

Researcher of the week.

Expérience académique

(2017) Vice-dean Graduate studies, Research and Innovation. Université de Sherbrooke.

Présentation

Sujets de recherche

Cancer de l'appareil digestif, Signalisation cellulaire et cancer, Oncogènes, Carcinogenèse.

Disciplines de recherche

Gastroentérologie, Biologie cellulaire, Oncologie.

Mots-clés

Biologie cellulaire, Oncologie, Épithélium, Protéines phosphatases, Cycle cellulaire, Transduction du signal, Culture des cellules, Prolifération, Système gastrointestinal, Protéines kinases.

Intérêts de recherche

Intestinal oncogenesis and tumorigenesis, colorectal cancer signaling, inflammatory cell signaling, epithelial cell biology, studies on intracellular signaling pathways including the KRAS/MAP kinase, PI3K/PTEN/AKT, Wnt/beta-catenin, SHP-1/SHP-2 pathways.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2020) Editorial Board Member of World J Gastrointestinal and Pathophysiology. World Jounal of Gastrointestinal Pathophysiology. (Distinction).
  • (2018) Canada Research Chair in colorectal and inflammatory cell signalling. Canada research Chair Program. (Distinction).
  • (2013) Research Excellence Award from the Canadian Association of Gastroenterology. Canadian Association of Gastroenterology. (Prix / Récompense).
  • (2012) Canada Research Chair in Digestive physiopathology and signalling. Canada research Chair Program. (Distinction).
  • (2006) Pierre-et-Danielle-Bourgaux Prize. Université de Sherbrooke. (Prix / Récompense).
  • (2006) Young Investigator Award of the Canadian Association of Gastroenterology. L'Association Canadienne de Gastroentérologie. (Prix / Récompense).
  • (2004) Researcher of the week. Canadian for Health Research. (Distinction).
  • Editorial Board of Gastrointestinal Cancer: Targets and Therapy. Gastrointestinal Cancer: Targets and Therapy. (Distinction).
  • Editorial board de Médecine Sciences. Médecine Sciences. (Distinction).
  • Editorial board of International Journal of Oncology. International Journal of Oncology. (Distinction).
  • Etienne-LeBel research excellence award. Université de Sherbrooke. (Prix / Récompense).
  • Fellow from American Gastroenterological Association. American Gastroenterological Association. (Distinction).
  • RECMUS Prize : An award given by the Université de Sherbrooke to an outstanding mentor and professor. Université de Sherbrooke. (Prix / Récompense).

Financement

(Obtenu). Chercheur principal. Canada Research Chair in colorectal cancer and inflammatory cell signaling. Instituts de Recherche en Santé du Canada (IRSC). Canada Research Chair. 1400000 $ (2018-2025).

Subvention. (En cours d’évaluation). Chercheur principal. A critical role for DUal Specificity Phosphatase 4 in intestinal oncogenesis?. Instituts de Recherche en Santé du Canada (IRSC). Operating grant. 1050000 $ (2019-2024).

Subvention. (Obtenu). Chercheur principal. A critical role for DUal Specificity Phosphatase 4 in intestinal oncogenesis?. Instituts de Recherche en Santé du Canada (IRSC). Project Grant-Bridge. 100000 $ (2018-2019).

Subvention. (Terminé). Chercheur principal. Role of SHP-1 in the control of intestinal epithelial proliferation and differentiation. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Découverte. 216000 $ (2012-2019).

Subvention. (Terminé). Co-demandeur. In vivo studies of autophagy: from the model organism to human organoids. Fondation Canadienne pour l'Innovation (FCI). Leaders. 372960 $ (2017-2018).

Subvention. (Terminé). Co-chercheur. The Sherbrooke Personalized Colorectal Cancer Avatar Models Initiative (COLOR project). MERCK-Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke. Programme de subvention MERCK Sharp & Dohme. 250000 $ (2016-2018).

Subvention. (Terminé). Co-chercheur. La culture organoïde : le chainon manquant pour le pronostic et le traitement optimisé des cancers du côlon, de la prostate et du pancréas. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Projets structurants. 50000 $ (2016-2017).

Publications

Articles de revue

  • Beaudry K*, MJ Langlois, A Montagne*, S Cagnol*, JC Carrier, N Rivard. (2019). Loss of dual specificity phosphatase-6 protects the colonic epithelium against inflammation but promotes proliferation and tumorigenesis. Journal of Cell Physiology, 234(5), 6731-6745. (Article publié).
  • Gagné-Sansfaçon J*, A Langlois*, G Coulombe*, S Tremblay, V Vaillancourt-Lavigueur*, MJ Langlois, CK Qu, A Menendez, N Rivard. (2019). Shp-2/ERK signalling drives intestinal epithelial regeneration and confers resistance to mucosal erosion and colitis. Journal of Pathology, 247(1), 135-146. (Article publié).
  • Leblanc C*, MJ Langlois, G Coulombe*, V Vaillancourt-Lavigureur*, JC Carrier, F Boudreau, and N Rivard. (2017). Epithelial Src Homology region 2 domain-containing Phosphatase-1 restrains intestinal growth, secretory cell differentiation and tumorigenesis. Faseb J, 31, 3512-3526. (Article publié).
  • Bian B*, S Mongrain, S Cagnol*, MJ Langlois, J Boulanger*, G Bernatchez JC Carrier, F Boudreau, N Rivard. (2016). Cathepsin B promotes colorectal tumorigenesis, cell invasion and metastasis. Molecular Carcinogenesis, 55, 671-687. (Article publié).
  • Gonneaud A, Turgeon N, Boudreau F, Perreault N, Rivard N, Asselin C. (2016). Distinct Roles for Intestinal Epithelial Cell-Specific Hdac1 and Hdac2 in the Regulation of Murine Intestinal Homeostasis. J Cell Physiology, 231(2), 436-448. (Article publié).
  • Coulombe G*, Rivard N. (2016). New and unexpected biological functions for SHP-2 tyrosine phosphatase in the gastrointestinal tract. Cellular and Molecular Gastroenterology and Hepatology, 2(1), 11-21. (Article publié).
  • Gagné-Sansfaçon J*, G Coulombe*, MJ Langlois, A Langlois*, M Paquet, J Carrier, GS Feng, CK Qu, N Rivard. (2016). SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development. Oncotarget, 7(40), 65676-65695. (Article publié).
  • Coulombe G*, A Langlois*, G De Palma, MJ Langlois, JL McCarville, J Gagné-Sanfaçon*, N Perreault, GS Feng, P Bercik, F Boudreau, EF Verdu and N Rivard. (2016). SHP-2 phosphatase prevents colonic inflammation by controlling secretory celldifferentiation and maintaining host-microbiota homeostasis. Journal Cellular Physiology, 231(11), 2529-2540. (Article publié).
  • Lemieux E*, S Cagnol*, K Beaudry*, J Carrier, N Rivard. (2015). Oncogenic KRAS signalling promotes Wnt/β-catenin pathway through LRP6 in colorectal cancer. Oncogene, 34(38), 4914-4927. (Article publié).
  • Paquin MC*, Cagnol S*, Carrier JC, Leblanc C*, Rivard N. (2013). ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells. BMC cell biology, 14, 33-42. (Article publié).
  • Bernatchez G , Giroux V , Lassalle T , Carpentier AC , Rivard N , Carrier JC. (2013). ERRα metabolic nuclear receptor controls growth of colon cancer cells. Carcinogenesis, 34(10), 2253-2261. (Article publié).
  • Coulombe G* , Leblanc C*, Cagnol S*, Maloum F, Lemieux E*, Perreault N , Feng GS , Boudreau F , Rivard N. (2013). Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Molecular and cellular biology, 33(11), 2275-2284. (Article publié).
  • Paquin MC*, Leblanc C*, Lemieux E*, Bian B*, Rivard N. (2013). Functional impact of colorectal cancer-associated mutations in the transcription factor E2F4. International journal of oncology, 43(6), 2015-2022. (Article publié).
  • Jones C , St-Jean S , Fréchette I , Bergeron D , Rivard N , Boudreau F. (2013). Identification of a novel promyelocytic leukemia zinc-finger isoform required for colorectal cancer cell growth and survival. International journal of cancer., 133(1), 58-66. (Article publié).
  • Cagnol S*, Rivard N. (2013). Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. Oncogene, 32(5), 564-576. (Article publié).
  • Cagnol S*, Boucher MJ, Carrier JC, Rivard N. (2012). Aberrant activation of the KRAS/BRAF/MAP Kinase signalling pathway in colorectal and pancreatic cancers. Médecine/Sciences Amériques, 1, 86-103. (Article publié).
  • Roy SA , Langlois MJ*, Carrier JC, Boudreau F, Rivard N, Perreault N. (2012). Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes. World journal of gastroenterology : WJG, 18(14), 1579-1589. (Article publié).
  • Paquin MC*, Rivard N. (2012). E2F4 (E2F transcription factor 4, p107/p130 binding). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 16(8), 529-539. (Article publié).
  • Asselin C, Boudreau F, Gendron FP, Perreault N, Rivard N. (2012). Rôle des cellules épithéliales dans le contrôle de l'inflammation intestinale. Médecine/Sciences Amériques, 1, 86-103. (Article publié).
  • Pinier M*, Fuhrmann G , Galipeau HJ, Rivard N, Murray JA, David CS, Drasarova H, Tuckova L, Leroux JC, Verdu EF. (2012). The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues. Gastroenterology, 142(2), 316-325. (Article publié).
  • Lemieux E*, Boucher MJ, Mongrain S*, Boudreau F, Asselin C, Rivard N. (2011). Constitutive activation of the MEK/ERK pathway inhibits intestinal epithelial cell differentiation. American journal of physiology. Gastrointestinal and liver physiology, 301(4), G719-730. (Article publié).
  • Simoneau M*, Coulombe G*, Vandal G*, Vézina A, Rivard N. (2011). SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein. Cellular signalling, 23(1), 269-279. (Article publié).
  • Gaudet S, Langlois MJ*, Lue RA, Rivard N, Viel A. (2011). The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring. BMC cell biology, 12, 55-62. (Article publié).
  • Lussier CR, Brial F, Roy SA, Langlois MJ*, Verdu EF, Rivard N, Perreault N, Boudreau F. (2010). Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PloS one, 5(8), e12378-12385. (Article publié).
  • Langlois MJ*, Bergeron S*, Bernatchez G, Boudreau F, Saucier C, Perreault N, Carrier JC, Rivard N. (2010). The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PloS One, 5(12), 1542. (Article publié).
  • Bergeron S*, Lemieux E*, Durand V*, Cagnol S*, Carrier JC, Lussier JG, Boucher MJ, Rivard N. (2010). The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. Molecular cancer, 9, 271. (Article publié).
  • Lemieux, E., S. Bergeron, V. Durand, C. Asselin, C. Saucier and N. Rivard. (2009). Constitutively active MEK1causes epithelial to mesenchymal transition inintestinal epithelial cells and promotes tumor invasionandmetastasis. Int J Cancer, 125(7), 1575-1586. (Article publié).
  • Garneau, H., M.C. Paquin, J.C. Carrier, and N. Rivard. (2009). E2F4 expression is required for cell cycle progressionof normal intestinal crypt cells and colorectal cancer cells. J Cell Physiology, 221, 350-358. (Article publié).
  • Langlois, M.J., S.A. Roy, B.A. Auclair, C. Jones, F. Boudreau, J.C. Carrier, N. Rivard and N. Perreault. (2009). Epithelial phosphatase and tensin homolog regulates intestinal architecture and secretorycell commitment and acts as a modifier gene in neoplasia. Faseb J, 23(6), 1835-1844. (Article publié).
  • Siqueira, J.M., A.C. Gazola, M.R. Farias, L. Volkov, N. Rivard, A.J. de Brum-Fernandes, and R.M. Ribeirodo- Valle. (2009). Evaluationof the antitumoral effect of dihydrocucurbitacin-B in both in vitro and in vivomodels. Cancer Chemother Pharmacol, 64(3), 529-538. (Article publié).
  • Rivard N. (2009). Phosphatidylinositol 3-kinase: a keyregulator in adherens junction formation and function. Frontiers in Biosciences, 14, 510-522. (Article publié).
  • Pinier, M., E.M. Verdu, M. Nasser-Eddine, N. Rivard* and J.C. Leroux*. (2009). Suppressionof gliadin-induced toxicity by poly(hydroxyethylmethacrylate-co-sodium4-styrene sulfonate): A potential supportive treatment for celiac disease. Gastroenterology, 136(1), 288-298. (Article publié).

Chapitres de livre

  • Paquin MC* and N Rivard. (2012). E2F4 transcription factor. Atlas of Genetics and Cytogenetics in Oncology and Haematology France : http://AtlasGeneticsOncology.org. (Article publié).
  • Saucier C, Rivard N. (2010). Epithelial cell signalling in colorectal cancer metastasis. Metastasis of colorectal cancer. (14, 205-242). États-Unis : Springer. (Article publié).

Documents de travail

  • Raisch J, MJ Langlois, N Rivard. (2018). The Wnt co-receptor LRP6 reduces inflammation and enhances intestinal regeneration.
  • Prinos P, B Chabot, N Rivard. (2016). KRAS signalling modulates EJC complex activity during colorectal carcinogenesis.

Articles de conférence

  • Langlois MJ, A Langlois, J Gagné-Sansfaçon, C Jones, F Boudreau and N Rivard. (2016). Development of intestinal organoid models to study the cellular functions of Shp-2. Embo Conferences, Organoids: modelling organ development and disease in 3D culture. (Article accepté).
  • Gagné-Sansfaçon J, S Tremblay, CK Qu, A Menedez and N Rivard. (2016). Epithelial SHP-2 activation protects the intestinal mucosa against colitis induced by dextran sulphate sodium or citrobacterrodentium. Canadian Digestive Diseases Week - CDDW 2016. (Article publié).
  • Gagné-Sansfaçon J, V Vaillancourt-Lavigueur, S Tremblay, CK Qu, A Menendez and N Rivard. (2016). Epithelial SHP-2 protects the intestinal mucosa against colitis and colorectal cancer. BEST PRESENTATION award. Faseb Research Conferences, Protein Phosphatases, Steamboats Springs, Colorado. (Article publié).
  • Gagné-Sansfaçon J, MJ Langlois, CK Qu, and N Rivard. (2016). Functional impact of colorectal cancer-associatedmutations in the tyrosine phosphatase SHP-2. Canadian Digestive Diseases Week - CDDW 2016. (Article publié).
  • Langlois A, MJ Langlois, J Gagné-Sans-façon, C Jones, F Boudreau et N Rivard. (2016). Implication importante de la tyrosine phosphatase Shp-2 dans le développement et lacroissance d’organoïdes intestinaux. Signalisation Québec 2016. (Article accepté).
  • Gagné-Sansfaçon J, V Vaillancourt-Lavigueur, S Tremblay, CK Qu, A Menendez et N Rivard. (2016). La protéine phosphatase SHP-2 protège la muqueuse intestinale de l’inflammation. Signalisation Québec 2016. (Article accepté).
  • Beaudry K, A Montagne, MJ Langlois, S Cagnol, and N Rivard. (2016). Role of the phosphatase DUSP6 in the control ofintestinal tumorigenesis and inflammation. CAG Student Prize. Canadian Digestive Diseases Week, CDDW 2016. (Article publié).
  • Leblanc C, V Vaillancourt-Lavigueur, MJ Langlois, et N Rivard. (2016). Régulation de la croissance cellulaire par la phosphatase Shp-1 et impact sur la tumorigénèse intestinale. Signalisation Québec 2016. (Article accepté).
  • Leblanc C, MJ Langlois, G Coulombe and N Rivard. (2016). The role of SHP-1 as a tumor suppressor gene inintestinal epithelium. Canadian Digestive Diseases Week, CDDW 2016. (Article publié).
  • Leblanc C, MJ Langlois, N Rivard. (2015). Epithelial tyrosine phosphatase Shp-1 controls growth and secretory cell differentiation in the small intestine (oral presentation). Gastroenterology, (Article publié).
  • Gagné-Sansfaçon J, G Coulombe, A Langlois, MJ Langlois, M Paquet and N Rivard. (2015). Laphosphatase SHP-2 est un suppresseur de tumeur pour le cancer colorectal associé à la colite. Club de Recherches Cliniques du Québec, CRCQ 2015. (Article publié).
  • Leblanc C, MJ Langlois, N Rivard. (2015). La tyrosine phosphatase Shp-1 régule l’homéostasie de l’épithéliumintestinal en contrôlant l’activation de la voie PI3K/Akt. HANS SELYE Award. Club de Recherches Cliniques du Québec, CRCQ 2015. (Article publié).
  • Langlois A, G Coulombe, MJ Langlois and N Rivard. (2015). L’inactivation de la signalisation TLR/Myd88 atténue l’inflammation intestinale des sourisdéficientes pour l’expression de la phosphatase SHP-2. Club de Recherches Cliniques du Québec. CRCQ 2015. (Article publié).
  • Beaudry K, MJ Langlois, S Cagnol and N Rivard. (2015). Rôlede la phosphatase Dusp6 dans la tumorigénèse et la réponse inflammatoireintestinale. PRIX de la relève. Club de Recherches Cliniques du Québec, CRCQ 2015. (Article publié).
  • Leblanc C, MJ Langlois, G Coulombe, and N Rivard. (2015). SHP-1 protein tyrosine phosphatase negatively modulates growth and Goblet/Paneth cell fate decisions through PI3K/Akt signalling in the intestinal epithelium. Canadian Digestive Diseases Week. (Article publié).
  • Gagné-Sansfaçon J, G Coulombe, A Langlois, MJ Langlois, M Paquet, and N Rivard. (2015). SHP-2 can act as a tumor suppressor gene in colorectal carcinogenesis. Canadian Digestive Diseases Week. (Article publié).
  • Langlois A, G Coulombe, MJ Langlois, S Cagnol, F Boudreau, G de Palma, P Bercik, EF Verdu and N Rivard. (2015). SHP-2/ERK signalling controls barrier function in the colon. Oral Presentation. Canadian Digestive Diseases Week. (Article publié).
  • Gagné-Sansfaçon J, G Coulombe, A Langlois, MJ Langlois, M Paquet, N Rivard. (2015). Tyrosine phosphatase SHP-2 prevents development of inflammation-associated colon cancer. Faseb research conferences. Gastrointestinal Tract XVI: GI Homeostasis: The Microbiome and the Barrier, Development, & Disease. (Article publié).
  • Coulombe C, Leblanc C, Langlois MJ, Verdu EF, de Palma G, Bercik P, Rivard N. (2014). Colonic cell fate dysregulation: cause or consequence of inflammation ?. Canadian Digestive Diseases Week. (Article sous presse).
  • J GagnéSanfacon, G Coulombe, A Langlois, N Rivard. (2014). La protéine tyrosine phosphatase SHP-2 est un suppresseur de tumeur lors du développement du cancer associé à la colite ulcéreuse. Nominated for Jacques-Genest Prize. Club de recherches cliniques du Québec. (Article accepté).
  • A Langlois, G Coulombe, N Rivard. (2014). La signalisation SHP-2/ERK/MAP kinase contrôle la détermination cellulaire et promeut la fonction barrière de l’épithélium colique. Club de recherches cliniques du Québec. (Article accepté).
  • J GagnéSansfacon, G Coulombe, A Langlois, N Rivard. (2014). L’inflammation intestinale engendrée par la deletion de SHP-2 dans l’épithélium promot la tumorigénèse colorectale * Best presentation award, PhD. Signalisation Québec 2014. (Article accepté).
  • GagnéSansfacon J, Coulombe G, Bourdages N, Rivard N. (2014). Role of SHP-2 tyrosine phosphatase in colorectal carcinogenesis. AACR 2014 (American Association of Cancer Research), San Diego, USA. (Article publié).
  • C Leblanc, G Coulombe, N Rivard. (2014). SHP-1 contrôle l’homéostasie de l’épithélium intestinal Best presentation award, MSc. Signalisation Québec. (Article accepté).
  • J Gagné Sanafacon, G Coulombe, N Rivard. (2013). Expression et role de la phosphatase SHP-2 dans le cancer colorectal. Club de recherches cliniques du Québec. (Article publié).
  • C Leblanc, G Coulombe, N Rivard. (2013). Implication de la tyrosine phosphatase dans le cancer colorectal. Club de recherches cliniques du Québec. (Article publié).
  • Langlois MJ, Roy SB, Roy E, Carrier J, Perreault N Boudreau F, Rivard N. (2013). Pten and p27 cooperation in intestinal morphogenesis and neoplasia. Keystone Symposia - PI 3-Kinase and Interplay with Other Signaling Pathways (X3). (Article accepté).
  • G Coulombe, EF Verdu, G de Palma, P Bercik, N Rivard. (2013). SHP-2 contrôle la determination cellulaire de l’épithélium colique. Club de recherches cliniques du Québec. (Article accepté).
  • Gagné-Sansfacon, J, G Coulombe, N Rivard. (2013). SHP-2 negatively regulates colorectal carcinogenesis. Canadian Digestive Diseases Week. (Article publié).
  • Lemieux, E and N Rivard. (2013). The WNT-b-catenin pathway is involved in KRAS-induced intestinal epithelial cell transformation. Canadian Digestive Diseases Week. Victoria, BC. (Article publié).
  • Lemieux E, Rivard N. (2013). The Wnt/b-catenin pathway contributes to intestinal epithelial cell transformation by oncogenic KRAS/MAPK signalling. Digestive Diseases Week. (Article publié).
  • Coulombe, G, C Leblanc, MJ Langlois, F Boudreau, N Rivard,. (2013). The tyrosine phosphatase SHP-2 regulates inflammation by controlling intestinal epithelial cell response to microflora. Canadian Digestive Diseases Week. (Article publié).
  • Coulombe G, Leblanc C, Langlois MJ, Maloum F, Lemieux E, Perreault N, Feng GS, Boudreau F, Rivard N. (2012). Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation and colorectal cancer. Received a Keystone symposia future of science fund scholarship. Keystone Symposia on molecular and cellular biology. The role of inflammation during carcinogenesis. Dublin, Ireland. (Article accepté).
  • Montagne A, S Cagnol, N Rivard. (2012). Régulation de la phosphatase DUSP6 par la voie de signalisation RAS-RAF-MEK-ERK lors de la tumorigénèse intestinale. Club de Recherche Clinique du Québec. (Article publié).
  • Coulombe G, C Leblanc, MJ Langlois, F Boudreau, N Rivard. (2012). SHP-2 régule l’inflammation en contrôlant la réponse des cellules épithéliales intestinales à la microflore. Club de Recherche Clinique du Québec. (Article publié).
  • Lemieux E, Rivard N. (2012). The Wnt/b-catenin pathway is involved in KRAS-induced intestinal epithelial cell transformation. American Association for Cancer Research Meeting. (Article accepté).
  • Lemieux E, G Chevalier-Soudeyns, S Cagnol and N Rivard. (2012). The cyclin-dependent kinase CDK8 is a novel target of ERK signaling involved in human colorectal cancer. Canadian Digestive Diseases Week. (Article accepté).
  • Coulombe G, S Cagnol, C Leblanc, F Maloum, É Lemieux, F Boudreau and N Rivard. (2012). The tyrosine phosphatase SHP-2 protects against intestinal inflammation. Digestive Disease Week. San Diego. (Article publié).
  • Coulombe G, C Leblanc and N Rivard. (2011). La protéine tyrosine phosphatase SHP-2 contrôle la prolifération et la sénescence des cellules épithéliales intestinale. Club de Recherche Clinique du Québec. (Article accepté).
  • Chevalier-Soudeyns G, S Cagnol, E Lemieux and N Rivard. (2011). Role of cdk8 in colorectal cancer. ACFAS 2011. (Article accepté).
  • Coulombe G, C Leblanc, and N Rivard. (2011). SHP-2 protects intestinal epithelial cells against oncogenic stress by inducing senescence. Canadian Digestive Diseases Week. (Article accepté).
  • Bian B, S Mongrain, F Boudreau and N Rivard. (2011). The role of cathepsin B in colorectal tumorigenesis. AACR, American Association for Cancer Research. (Article publié).
  • Paquin MC and N Rivard. (2010). Dual regulation of E2F4 transcription factor by ERK and GSK3 kinases. ASCB 50th Annual Meeting. (Article accepté).
  • Bian B, S Mongrain and N Rivard. (2010). Implication de la cathepsine B dans les processus tumorigeniques colorectaux. Club de Recherche Clinique du Québec. 23-25. (Article accepté).
  • Coulombe G, M Simoneau, and N Rivard. (2010). Regulation of b-catenin function by the tyrosine phosphatase SHP-1 in human intestinal epithelial cells. ASCB 50th Annual Meeting. (Article accepté).
  • Cagnol S, E Lemieux and N Rivard. (2010). The dual-specificity phosphatases DUSP/MKP: key regulators of the Ras/Raf/ERK pathway in colorectal tumorigenesis. Digestive Diseases Week. (Article accepté).
  • Paquin MC and N Rivard. (2010). Une forme alternative du co-facteur de transcription DP2 est surexprimée dans les cellules cancéreuses colorectales humaines. Club de Recherche Clinique du Québec. (Article accepté).
  • Raisch J, A Côté-Biron, MJ Langlois and N Rivard. LRP6 is required for crypt regeneration and for proper intestinal epithelial protection against inflammation. Digestive Diseases Week.
  • Rivard N, V Vaillancourt-Lavigueur, J Gagné-Sansfaçon, MJ Langlois. SHP-2 promotes intestinal epithelial regenerationand tumorigenesis. Europhosphatases -EMBO Conferences.
  • Côté-Biron A, J Raisch, and N Rivard. The Wnt co-receptor LRP6 promotes growth of colorectal cancer cells. Canadian Digestive Diseases Week.
  • Raisch J, A Côté-Biron, MJ Langlois, and N Rivard. The Wnt co-receptor LRP6 reduces inflammation and enhances intestinal regeneration. Canadian Digestive Diseases Week.

Autres contributions

Gestion d'évènements

  • Co-organizer. (2014). 55ième Réunion annuelle du Club de Recherches Cliniques du Québec, Ste-Adèle, Québec. (Conférence).
  • Co-organizer. (2013). 55ième Réunion annuelle du Club de Recherches Cliniques du Québec, Lac Delage, Québec. (Conférence).
  • Co-organizer. (2012). 54ième Réunion annuelle du Club de Recherches Cliniques du Québec, Orford, Québec. (Conférence).
  • Co-organizer. (2010). 4th Symposium Signalisation Québec. (Conférence).
  • Co-organizer. Signalisation Quebec 2016. (Conférence).

Activités de collaboration internationale

  • Collaborator with M. Chamaillard. (2015). France. Collaboration on a project on the role of antimicrobial peptides in intestinal homeostasis.
  • Collaborator with JC Leroux. (2010). Suisse. Project: Prevention gliadin effects in celiac disease.
  • Collaborator with GS Feng. (2012). États-Unis. Project: Roleof SHP-2 phosphatase in intestinal inflammation.
  • Collaborator with Cheng-Kui Qu. (2013). États-Unis. Project: Role of SHP-2 phosphatase in intestinaltumorigenesis and cancer.

Présentations

  • Rivard N. (2019). Shp-2 phosphatase: a critical regulator of colonocytes in IBD. Canadian Digestive Diseases Week 2019, Banff. Canada.
  • (2018). Rôle de LRP6 dans l'action pro-oncogénique de la signalisation Ras/MAP kinase. Signalisation QUÉBEC 2018. Bécancour, Canada.
  • Rivard N. (2017). Complex regulation of ERK signaling during colorectal carcinogenesis. KEYNOTE Lecture. 10th Annual Cancer Congress. Barcelona, Espagne.
  • Rivard N, V Vaillancourt-Lavigueur, J Gagé-Sansfaçon, MJ Langlois. (2017). SHP-2 promotes intestinal epithelial regeneration and tumorigenesis. Europhosphatases: Phosphatases in cell fates and decisions. Embo Conference. Paris, France.
  • (2017). Shp-2 : une phosphatase au cœur de l’inflammation et du cancer du côlon. Conférencière invitée, Département de Pharmacologie, Université de Montréal. Montréal, Canada.
  • Rivard N. (2016). Epithelial SHP-2 protects the intestinal mucosa against colitis and colorectal cancer. KEYNOTE Lecture. 7th European Pediatrics Conference, Amsterdam. Amsterdam, Pays-Bas.
  • (2016). SHP-2 est-il un oncogène pour l’épithélium intestinal ?. Signalisation Québec 2016. Bécancour, Canada.
  • Rivard N. (2016). The complex role of SHP-2 tyrosine phosphatase in the development of colorectal cancer. KEYNOTE Lecture. 6th Global Gastroenterologists meeting. Birmingham, Royaume-Uni.
  • (2016). The complex role of SHP-2 tyrosine phosphatase in the development of colorectal cancer. KEYNOTE Lecture. 8th International Conference on Clinical Gastroenterology & Hepatology,. Toronto, Canada.
  • Leblanc C, MJ Langlois, N Rivard. (2015). Epithelial tyrosine phosphatase Shp-1 controls growth and secretory cell differentiation in the small intestine. Digestive Diseases Week. Washington, États-Unis.
  • (2015). La phosphatase SHP-2 contrôle la fonction barrière de l'épithélium intestinal. Conférence invitée au LOEX, Université Laval. Québec, Canada.
  • Rivard N. (2015). Oncogenic KRAS promotes the Wnt/β-catenin signaling pathway through LRP6 during colorectal oncogenesis. 20th World Congress on Advances in Oncology & 18th International Symposium of molecular medicine. Athènes, Grèce.
  • (2015). SHP-2, a tyrosine phosphatase that protects against inflammation and cancer in the colon. KEYNOTE Lecture. Canadian Digestive Diseases Week 2015 (Symposium Inflammation-Cancer). Banff, Canada.
  • (2015). The dual functions of SHP-2 tyrosine phosphatase in colorectal cancer. Atelier sur la recherche en cancer- National Science Foundation of China (NSFC)-FRQS. Shanghai, Chine.
  • (2014). Dual functions of SHP-2 tyrosine phosphatase in colorectal cancer. Cancer Science 2014. Chicago, États-Unis.
  • Leblanc C, Coulombe G, Langlois MJ, Rivard N. (2014). Involvement of the SHP-1 tyrosine phosphatase in regulating intestinal epithelial cell signaling, proliferation and tumorigenesis. Canadian Digestive Diseases Week. Toronto, Canada.
  • N Rivard. (2014). Protein tyrosine phosphatases in the intestinal epithelium: emerging regulators of inflammation and tumorigenesis. 35th Anniversary Symposium "Growth Control Lab". Nice, France.
  • (2014). Role of SHP-2 phosphatase in the regulation of intestinal homeostasis. Conférence invitée à l'INSERM UMR-1043, Centre de pathophysiologie de Toulouse Purpan. Toulouse, France.
  • (2014). SHP-2 régule l'inflammation en contrôlant la réponse des cellules épithéliales intestinales à la microflore. Signalisation Québec 2014. Bécancour, Canada.
  • (2014). Understanding the dual nature of SHP-2 in colorectal cancer. 19th World Congress on Advances in Oncology & 17th Internation Symposium of molecular medicine. Athènes, Grèce.
  • Rivard N. (2013). A role for DUSP4 phosphatase in colorectal carcinogenesis ?. The Rosalind and Morris Goodman Cancer Research Centre, Montreal. Montréal, Canada.
  • Rivard N. (2013). Contribution de la signalisation Wnt/b-caténine dans l'effet oncogénique de la voie KRAS/MAP Kinase. ACFAS 2013, Colloque sur l'oncologie. Québec, Canada.
  • Langlois MJ, Roy SB, Roy E, Carrier J, Perreault N Boudreau F, Rivard N. (2013). Pten and p27 cooperation in intestinal morphogenesis and neoplasia. Keystone Symposia - PI 3-Kinase and Interplay with Other Signaling Pathways (X3). Keystone, États-Unis.
  • Rivard, N. (2013). Signalling pathways in intestinal epithelial cells: decisions to cycle, to differentiate, to transform and to inflame. Canadian Digestive Diseases Week (Research Excellence Lecture). Victoria, Canada.
  • Langlois MJ, SB Roy, E Roy, N Perreault, F Boudreau, N Rivard. (2012). Coopération de PTEN et de p27 dans le maintien de l’homéostasie intestinale. Club de Recherche Clinique du Québec, Orford. Orford, Canada.
  • Placet M, G Chevalier-Soudeyns, E Lemieux, C Asselin, N Rivard. (2012). Rôle de CDK8 dans la tumorigénèse colorectale. Club de Recherche Clinique du Québec, Orford. Orford, Canada.
  • Coulombe G, C Leblanc, MJ Langlois, F Boudreau, N Rivard. (2012). SHP-2 régule l’inflammation en contrôlant la réponse des cellules épithéliales intestinales à la microflore. Club de Recherche Clinique du Québec, Orford. Orford, Canada.
  • Coulombe C, S Cagnol, C Leblanc, F Maloum, É Lemieux, F Boudreau, N Rivard. (2012). The tyrosine phosphatase SHP-2 protects against intestinal inflammation. Digestive Disease Week, San Diego. San Diégo, États-Unis.
  • Rivard N. (2012). Un rôle pour DUSP4 dans la carcinogénèse colorectale ?. Signalisation Québec 2012, Bécancour QC. Bécancour, Canada.
  • Rivard N. (2011). Cooperative regulation of the metastatic potential by the PI3K and ERK signaling pathways. Montreal International Symposium on Angiogenesis and Metastasis (MISAM 2011). Montréal, Canada.
  • Rivard N. (2011). Epithelial cell signalling in colorectal carcinogenesis. 1st International symposium in digestive physiopathology. Orford, Canada.
  • Rivard N. (2011). Implications de la phosphorylation et la surexpression du facteur de transcription E2F4 dans la tumorigénèse intestinale. ACFAS 2011, Sherbrooke. Sherbrooke, Canada.
  • Cagnol S, Rivard N. (2011). La phosphatase nucléaire MKP2/DUSP4 est un régulateur crucial de la voie Ras/RAF/ERK dans la tumorigenèse colorectale. Club de Recherche Clinique du Québec, Sainte-Adèle. Sainte-Adèle, Canada.
  • Rivard N. (2011). Role of DUSPs in colorectal carcinogenesis. 16th World Congress on advances in oncology & 14th international Symposium on molecular medicine. Rhodes, Greece. Rhodes, Greece, Grèce.
  • Rivard N. (2011). Rôle et régulation du sentier de signalisation ERK MAP Kinases dans la carcinogénèse colorectale. Centre de recherche sur le cancer de l’Hôtel-Dieu de Québec. Québec, Canada.
  • Coulombe G, E Lemieux, F Boudreau, N Rivard. (2011). The tyrosine phosphatase SHP-2 protects against intestinal inflammation. Canadian Digestive Diseases Week, Vancouver, Canada Recipient of Canadian of the Association of Gastroenterology Student Research Prize. Vancouver, Canada.
  • N Rivard. (2010). Role of PTEN in colorectal carcinogenesis. 15th World Congress on advances in oncology & 13th international Symposium on molecular medicine. Athens, Grèce.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.