Paquette, Benoît

Professeur, Faculté de médecine et des sciences de la santé
FMSS Dép. médecine nucléaire et radiobiologie

Coordonnées

Courriel


819-821-8000, poste 74767


Site Web

Diplômes

(1991) Doctorat (Doctor of Philosophy). Université de Sherbrooke.

(1987) Maîtrise avec mémoire (Master of Science - Maîtrise). Université de Sherbrooke.

(1985) Baccalauréat (Bachelor of Science). Université de Sherbrooke.

Titres de compétence

(2017) Director, Département de médecine nucléaire et radiobiologie. Université de Sherbrooke.

(2012) Directeur, axe de recherche en imagerie médicale et radiothérapie.

(2012) Director.

Présentation

Sujets de recherche

Cancer de l'appareil digestif, Cancer du sein, Carcinogenèse, Cellules souches et organogénèse, Radiothérapie, Thérapie cellulaire du cancer, Tumeurs cérébrales.

Disciplines de recherche

Biologie moléculaire, Oncologie.

Mots-clés

Brain cancer, Breast cancer, Cancer cell invasion, Cancer colorectal, Cancer du cerveau, Cancer du sein, Chimio-radiotherapy, Colo-rectal cancer, Free radicals, Hydroxyestrogens, Mesenchymal stem cells, Métastase, Metastasis, Oxydatif stress, Radiation therapy, Radiosensitizers, Radiotherapy, radiotherapy optimisation.

Intérêts de recherche

Brain plasticity, radiation therapy, brain cancer, magnetic resonance imaging, cell migration, inflammatory cytokines

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2016) Scientific committee. 30th Annual meeting of Canadian Association of Radiation Oncologist. (Distinction).
  • (2016) International expert in the committee that guides research in protontherapie in France. Scientific Advisor Board - France Hadron. (Distinction).
  • (2015) Vice-president. Société internationale de radiobiologie de langue française. (Distinction).
  • (2013) Scientific committee. 11ème Colloque International de Radiobiologie Fondamentale et Appliquée (CIRFA). (Distinction).
  • (2013) Scientific committee. CARO-COMP 2013 Joint Scientific Meeting. (Distinction).
  • (2011) Scientific committee. 10e Colloque International de Radiobiologie Fondamentale et Appliquée. (Distinction).
  • (2010) Scientific committee. 24th Canadian Association of Radiation Oncologist Scientific meeting. (Distinction).
  • (2010) Scientific committee. 2e Congrès International - Radiations Médicales: Recherche et Applications. (Distinction).
  • Publication of the year, Canadian Institutes of Health Research - Cancer. CIHR. (Distinction).
  • Scientific committee. 12ème Colloque International de Radiobiologie Fondamentale et Appliqué. (Distinction).

Financement

Subvention. (En cours d’évaluation). Chercheur principal. Vectorized radiotherapy developed to treat ovarian cancer. (2019-2024).

Subvention. (En cours d’évaluation). Co-demandeur. The small GTPase Rab4 as a target for breast cancer metastasis. (2018-2023).

Subvention. (En cours d’évaluation). Chercheur principal. Can radiotherapy increase the invasiveness of circulating tumor cells in triple-negative breast patients?. (2019-2021).

Subvention. (En cours d’évaluation). Co-chercheur. Development of a radioactive trap to eliminate cancer cells infiltrated in brain parenchyma. (2019-2021).

Subvention. (En cours d’évaluation). Chercheur principal. Prise en charge personnalisée et nouvelle stratégie thérapeutique pour éliminer les cellules tumorales infiltrées dans le parenchyme cérébral. (2018-2020).

Subvention. (Obtenu). Chercheur principal. Cibler les cellules du glioblastome infiltrées dans le parenchyme cérébral. (2018-2020).

Subvention. (Obtenu). Chercheur principal. Développement d’un hydrogel libérant des vésicules enrichies de TRAIL qui s’accumuleront dans les cellules cancéreuses du cerveau pour augmenter l’apoptose induite par les radiations. (2018-2019).

Subvention. (Terminé). Chercheur principal. Role of radiation in cancer cell invasion and metastasis development. (2010-2017).

Publications

Articles de revue

  • Julie Constanzo*, Matthieu Dumont, Luc Tremblay, Kevin Whittingstall, Laurence Masson‐Côté, Sameh Geha, Martin Lepage, Philippe Sarret, Benoit Paquette**, Maxime Descoteaux** (**Co-corresponding author). (2018). Diffusion MRI monitoring of microstructure in the irradiated rat brain. Magnetic Resonance in Medicine, 80, 1614-25. (Article publié).
  • Thititip Tippayamontri*, Brigitte Guérin, René Ouellet, Otman Sarrhini, Jacques Rousseau, Roger Lecomte, Benoit Paquette and Léon Sanche. (2018). Intra-tumoral 18F-FLT infusion in metabolic targeted radiotherapy. EJNMMI Research, (Article soumis).
  • Minghan Shi*, Malathi Anantha, Mohamed Wehbe, Marcel B. Bally, David Fortin, Laurent-Olivier Roy, Gabriel Charest, Maxime Richer, Benoit Paquette**, Léon Sanche** (** = Corresponding author). (2018). Liposomal formulation of carboplatin injected by convection-enhanced delivery significantly increased median survival of F98 glioma bearing rats. Journal of Nanobiotechnology, 16(1), 77-88. (Article publié).
  • Thititip Thippayamontri*, Minghan Shi*, Benoit Paquette, Andrew Bass and Léon Sanche. (2018). Radiosensitization Induced by Ultra-stable PVA-coated Gold Nanoparticles: A Study with Fricke Dosimeter, Plasmid DNA and F98 Glioma Cells. Current Nanomedicine, 8(2), 121-134. (Article publié).
  • Rosalie Lemay*, Benoit Paquette, Claude Pépin, Mélanie Archambault, Luc Tremblay, and Martin Lepage** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2017). Assessment by magnetic resonance imaging of angiogenesis in a Matrigel plus implanted in Balb/c mice. Microcirculation, .(.), . (Révisions requises).
  • Gina Bouchard*, Hélène Therriault*, Rachel Bujold, Caroline Saucier and Benoit Paquette**. (* = PHQ dans mon laboratoire, ** = Corresponding author). (2017). Induction of interleukin-1β by mouse mammary tumor irradiation promotes triple negativebreast cancer cells invasion and metastasis development. International Journal Radiation Biology, 93(5), 507-516. (Article publié).
  • Gina Bouchard*, Hélène Therriault*, Sameh Geha, Rachel Bujold, Caroline Saucier and Benoit Paquette** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2017). Radiation-induced lung metastasis development is MT1-MMP-dependent in a triple negative breast cancer mouse model. British Journal of Cancer, 116(2), 479-488. (Article publié).
  • Lemay R *, Lepage M , Tremblay L , Therriault H*, Charest G*, Paquette B. (2017). Tumor Cell Invasion Induced by Radiation in Balb/C Mouse is Prevented by the COX-2 Inhibitor NS-398. Radiation research, 188(6), 605-614. (Article publié).
  • Julie Constanzo*, Laurence Masson-Côté, Luc Tremblay, Philippe Sarret, Kevin Whittingstall, Jérémie Fouquet, Sameh Geha, Benoit Paquette** and Martin Lepage (** = Corresponding author). (2017). Understanding the Continuum of Radionecrosis and Vascular Disorders in Brain Following Gamma Knife Irradiation. Magnetic Resonance in Médicine, 78(4), 1420-1431. (Article publié).
  • Minghan Shi*, David Fortin, Benoit Paquette** and Léon Sanche (* = PHQ dans mon laboratoire, ** = Corresponding author). (2016). Convection-enhancement delivery of liposomal formulation of oxaliplatin shows less toxicity than oxaliplatin yet maintains a similar median survival time in F98 glioma-bearing rat model. Investigational New Drugs, 34(3), 269-276. (Article publié).
  • Minghan Shi*, Thititip Thippayamontri*, Louis Gendron, Brigitte Guérin, Benoit Paquette** and Léon Sanche. (* = PHQ dans mon laboratoire, ** = Corresponding author). (2016). Increased radio-sensitivity of colorectal tumor with intra-tumoral injection of low dose of gold nanoparticles. International Journal of Nanomedicine, 11, 5323-5333. (Article publié).
  • Guillaume Desmarais*, Gabriel Charest*, Hélène Therriault*, Minghan Shi*, David Fortin, Rachel Bujold, David Mathieu and Benoit Paquette** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2016). Infiltration of F98 glioma cells in Fischer rat brain is temporary stimulated by radiation. International Journal of Radiation Biology, 92(8), 444-450. (Article publié).
  • Gina Bouchard*, Hélène Therriault*, Sameh Geha, Yves Bérubé-Lauzière, Rachel Bujold, Caroline Saucier and Benoit Paquette** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2016). Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model. BMC Cancer, 16, 361-374. (Article publié).
  • Minghan Shi*, David Fortin, Léon Sanche and Benoit Paquette** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2015). Convection-enhancement delivery of platinum-based drugs and LipoplatinTM to optimize the concomitant effect with radiotherapy in F98 glioma rat model. Investigational New Drugs, 33, 555-563. (Article publié).
  • Guillaume Desmarais*, Gabriel Charest*, David Fortin, Rachel Bujold, David mathieu and Benoit Paquette** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2015). Cyclooxygenase-2 inhibitor prevents radiation-enhanced infiltration of F98 glioma cells in brain of Fisher rat. International Journal of Radiation Biology, 91(8), 624-638. (Article publié).
  • Julie Constanzo*, Benoit Paquette, Gabriel Charest*, Laurence Masson-Côté, Mathieu Guillot** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2015). Method to irradiate small areas in rat brain with a Gamma Knife based on dosimetric controls. Medical Physic, 42(5), 2311-2316. (Article publié).
  • Benoit Paquette. (2015). Triple Negative Breast Cancer. Encyclopedia of Cancer, On line, . (Article publié).
  • T. Tippayamontri*, R. Kotb, L. Sanche, B. Paquette** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2014). New therapeutic possibilities of combined treatment of radiotherapy with oxaliplatin and its liposomal formulations Lipoxal™ in rectal cancer using nude mouse xenograft. Anticancer Research, 34(10), 5303-5312. (Article publié).
  • Tippayamontri T* , Kotb R , Paquette B**, Sanche L (* = PHQ dans mon laboratoire, ** = Corresponding author). (2013). Efficacy of cisplatin and lipoplatin™ in combined treatment with radiation of a colorectal tumor in nude mouse. Anticancer Research, 33(8), 3005-3014. (Article publié).
  • Charest G* , Sanche L , Fortin D , Mathieu D , Paquette B** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2013). Optimization of the route of platinum drugs administration to optimize the concomitant treatment with radiotherapy for glioblastoma implanted in the Fischer rat brain. Journal of Neuro-Oncology, 115(3), 365-373. (Article publié).
  • Bouchard G*, Bouvette G, Therriault H*, Bujold R, Saucier C, Paquette B** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2013). Pre-irradiation of mouse mammary gland stimulates cancer cell migration and development of lung metastases. British Journal of Cancer, 109(7), 1829-1838. (Article publié).
  • Paquette B* *, Therriault H , Wagner JR (** = Corresponding author). (2013). Role of Interleukin-1β in radiation-enhancement of MDA-MB-231 breast cancer cell invasion. Radiation Research, 180(3), 292-298. (Article publié).
  • Meesat R, Belmouaddine H, Allard JF, Tanguay-Renaud C, Lemay R*, Brastaviceanu T, Tremblay L, Paquette B, Wagner JR, Jay-Gerin JP, Lepage M, Huels MA, Houde D** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2012). Cancer radiotherapy based on femtosecond IR laser-beam filamentation yielding ultra-high dose rates and zero entrance dose. Proceedings of the National Academy of Sciences of the United States of America, 109(38), E 2508- E 2513. (Article publié).
  • Charest G*, Sanche L, Fortin D, Mathieu D, Paquette B** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2012). Glioblastoma treatment: bypassing the toxicity of platinum compounds by using liposomal formulation and increasing treatment efficiency with concomitant radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 84(1), 244-249. (Article publié).
  • Desmarais G*, Fortin D, Bujold R, Wagner R, Mathieu D, Paquette B** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2012). Infiltration of glioma cells in brain parenchyma stimulated by radiation in the F98/Fischer rat model. International Journal of Radiation Biology, 88(8), 565-574. (Article publié).
  • Tippayamontri T*, Kotb R, Paquette B**, Sanche L (* = PHQ dans mon laboratoire, ** = Corresponding author). (2012). Synergism in concomitant chemoradiotherapy of cisplatin and oxaliplatin and their liposomal formulation in the human colorectal cancer HCT116 model. Anticancer Research, 32(10), 4395-4404. (Article publié).
  • Tippayamontri T*, Kotb R, Paquette B**, Sanche L (* = PHQ dans mon laboratoire, ** = Corresponding author). (2011). Cellular uptake and cytoplasm / DNA distribution of cisplatin and oxaliplatin and their liposomal formulation in human colorectal cancer cell HCT116. Investigational New Drugs, 29(6), 1321-1327. (Article publié).
  • Lemay R*, Archambault M, Tremblay L, Bujold R, Lepage M, Paquette B** (* = PHQ dans mon laboratoire, ** = Corresponding author). (2011). Irradiation of normal mouse tissue increases the invasiveness of mammary cancer cells. International Journal of Radiation Biology, 87(5), 472-482. (Article publié).
  • Paquette B**, Therriault H*, Desmarais G*, Wagner R, Royer R*, Bujold R (* = PHQ dans mon laboratoire, ** = Corresponding author). (2011). Radiation-enhancement of MDA-MB-231 breast cancer cell invasion prevented by a cyclooxygenase-2 inhibitor. British Journal of Cancer, 105(4), 534-541. (Article publié).
  • Rosalie Lemay*, Luc Tremblay, Melanie Archambault, M'hamed Bentourkia, Benoit Paquette et Martin Lepage**. (* = PHQ dans mon laboratoire, ** = Corresponding author). (2010). Cancer invasion monitored by a cluster analysis of T2-wighted and T1-weighted images in tumor-bearing irradiated mice. ISMRM, .(.), . (Article publié).
  • Charest G*, Paquette B**, Fortin D, Mathieu D, Sanche L (* = PHQ dans mon laboratoire, ** = Corresponding author). (2010). Concomitant treatment of F98 glioma cells with new liposomal platinum compounds and ionizing radiation. Journal of Neuro-Oncology, 97(2), 187-193. (Article publié).
  • Picard N, Ali H, van Lier JE, Klarskov K, Paquette B*. (2009). Bromines on N-allyl position of cationic porphyrins affect both radio- and photosensitizing properties. Photochemistry Photobiology Science, 8(2), 224-32. (Article publié).
  • Jastrzebska B, Lebel R, McIntyre OJ, Paquette B, Neugebauer W, Escher E, Lepage M. (2009). Monitoring of MMPs activity in vivo, non-invasively, using solubility switchable MRI contrast agent. Advances in experimental medicine and biology, 611, 453-4. (Article publié).
  • Jastrzebska B, Lebel R, Therriault H, McIntyre JO, Escher E, Guérin B, Paquette B, Neugebauer WA, Lepage M*. (2009). New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging. Journal of medicinal chemistry, 52(6), 1576-81. (Article publié).
  • Charest G, Mathieu D, Lepage M, Fortin D, Paquette B*, Sanche L. (2009). Polymer gel in rat skull to assess the accuracy of a new rat stereotactic device for use with the Gamma Knife. Acta neurochirurgica, 151(6), 677-83. (Article publié).
  • Lebel R, Jastrzebska B, Therriault H, Cournoyer MM, McIntyre JO, Escher E, Neugebauer W, Paquette B, Lepage M. (2008). Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 60(5), 1056-65. (Article publié).
  • Mir Y, van Lier JE, Paquette B, Houde D*. (2008). Oxygen dependence of two-photon activation of zinc and copper phthalocyanine tetrasulfonate in Jurkat cells. Photochemistry and photobiology, 84(5), 1182-6. (Article publié).
  • Paquette, B.*, Lemay, R., Pépin, C., Tremblay, L. and Lepage, M. (2008). The invasiveness of breast cancer cell is enhanced by radiation. Radiotherapy & Oncology, 88, S3. (Article publié).
  • Rosalie Lemay, Claude Pépin, Luc Tremblay, Benoit Paquette and Martin Lepage*. (2007). Follow-up study of in vivo breast cancer cell invasion by MRI. Proc. Int. Soc. Mag. Res. Med, 15, 2904.
  • Paquette B*, Baptiste C , Therriault H , Arguin G , Plouffe B , Lemay R. (2007). In vitro irradiation of basement membrane enhances the invasiveness of breast cancer cells. British journal of cancer, 97(11), 1505-1512. (Article publié).
  • Jastrzebska B, Lebel R, McIntyre JO, Paquette B, Escher E, and Lepage M. (2007). Monitoring of MMPs activity in vivo, non-invasively, using solubility switchable MRI contrast agent. Biopolymers, 88, 600-601. (Article publié).
  • Rosalie Lemay, Claude Pépin, Luc Tremblay, Benoit Paquette and Martin Lepage*. (2007). Non-invasive in vivo MRI angiogenesis assays. Proc. Int. Soc. Mag. Res. Med, 1613.
  • Rosalie Lemay, Jean-Philipe Tremblay-Morin, Hasrat Ali, Darel Hunting, Johan E. Van Lier and Benoit Paquette*. (2007). Synthesis and radiosensitizing properties of brominated tetrapyridine porphyrins. Journal of Porphyrins and Phthalocyanines, 11(8), 549-555. (Article publié).
  • Pellerin, M., Tremblay, L., Paquette, B., Lepage, M.*. (2006). Monitoring micro-vasculature damage induced by radiotherapy on mouse breast carcinomas using DCE-MRI. Proc. Intl. Soc. Mag. Reson. Med., 14, 2910.
  • Cantin, A.M., Martel, M., Drouin, G. and Paquette, B*. (2005). Inhibition of gelatinase B/MMP-9 by dihydrolipoic acid. Canadian Journal Physiology and Pharmacology, 83, 301-318.
  • Paquette, B.*, Bisson, M., Baptiste, C., Therriault, H., Lemay, R. and Cantin, A. M. (2005). Invasiveness of breast cancer cells MDA-MB-231 through extracellular matrix is increased by the estradiol metabolite 4-hydroxyestradiol. International Journal of Cancer, 113, 706-711.
  • Lauzon, K., Zhao, X., Bouetard, A., Delbecchi, L., Paquette, B. and Lacasse, P*. (2005). Neutrophil-induced mammary tissue damage : Antioxidants to Prevent Bovine Neutrophil-induced Mammary Epithelial Cell Damage. Journal of Dairy Science, 88, 4295-4303,.
  • Sané A. T., Cantin A.M., Paquette B. and Wagner, R.J. (2004). Ascorbate modulation of H2O2 and camptothecin-induced cell death in Jurkat cells. Cancer Chemotherarapy Pharmacology, 54, 315-321.
  • Drouin, G., Douillette, A., Bisson, M., Lacasse, P. and Paquette, B.*. (2004). Radiosensitizing effect of conjugated linoleic acid on tumor cells MCF-7 and MDA-MB-231. Canadian Journal Physiology Pharmacology, 82, 94-102.
  • Paquette, B.*, Bisson, M., Therriault, H., Lemay, R., Paré, M., Banville, P. and Cantin, A.M. (2003). Activation of matrix metalloproteinase-2 and –9 by 2- and 4-hydroxyestradiol. The Journal of Steroid Biochemistry and Molecular Biology, 87, 65-73.
  • Thibodeau, P.A. and Paquette, B.*. (2003). DNA strand breaks induced by the redox cycling of catecholestrogens in the presence of copper and modulation by reducing agents. Proc. Biennal Meeting Soc. Free Radical Res. Inter., ., 463-469.
  • Ali, H., Rousseau, J., Paquette, B., Dubé, C., Marko, B. and van Lier, J.E.*. (2003). E/ZSynthesis and target tissue uptake of the 7a-cyano derivatives of (17a,20)-[125I]iodovinyl- and 16a-[125I]iodo-estradiols. Steroids. Steroids, 68, 1189-1200.
  • Thibodeau, P.A., Lemay, R. et Paquette, B.*. (2002). Estrogènes : bénéfiques ou délétères ? Sur la piste des radicaux libres. Cahiers de radiobiologie, 13, 12-26,.
  • Thibodeau, P.A., Kachadourian, R., Lemay, R., Bisson, M., Day, B.J. and Paquette, B.*. (2002). In vitro pro- and antioxidant properties of estrogens. The Journal of Steroid Biochemistry and Molecular Biology, 81(3), 227.
  • Paquette, B.*, Cantin, A., Kocsis Bédard, S., Barry, S., Lemay, R. and Jay-Gerin, J.P. (2001). In vitro generation of peroxynitrite by 2- and 4-hydroxyestrogens in the presence of nitric oxide. Chemical Research in Toxicology, 14, 547-554.
  • Thibodeau P.A., Kocsis Bédard, S., Courteau, J., Niyonsenga, T. and Paquette, B.*. (2001). Thiols can either enhance or suppress DNA damage induction by 4-hydroxyestradiol. Free Radical Biology Medicine, 30, 62-73.
  • Cantin, A.M., Paquette, B., Richter, M. and Larivée P. (2000). Albumin-mediated regulation of cellular glutathione and nuclear factor KappaB activation. American Journal of Respiratory and Critical Care Medicine, 162, 1539-1546.
  • Paquette, B., Fortier, P.K., Héroux, J., Thibodeau, P., Wagner, R., Liu, J. and Cantin, A. (2000). OOestrogen metabolism in lymphangioleiomyomatosis: catechol--methyltransferase is not involved. Thorax, 55, 574-578.
  • Thibodeau, P.A. and Paquette, B.*. (1999). DNA damage induced by catecholestrogens in the presence of copper (II): Generation of reactive oxygen species and enhancement by NADH. Free Radial Biology Medicine, 27, 1367-1377.
  • Thibodeau, P.A., Bissonnette, N., Kocsis Bédard, S., Hunting, D. and Paquette, B.*. (1998). Induction by estrogens of methotrexate resistance in the MCF-7 breast cancer cells. Carcinogenesis, 19, 1545-1552.
  • Paquette, B.*. (1996). Enhancement of genomic instability by 17-estradiol in minisatellite sequences of X-ray-transformed mouse 10T½ cells. Carcinogenesis, 17, 1221-1225.
  • Paquette, B.*, Wagner, R. and Little, J.B. (1996). In vitro reversion of transformed phenotype in mouse C3H/10T½ cells: Modification in genomic 5-methylcytosine content. International Journal of Oncology, 8, 727-734.
  • Paquette, B. and Little, J.B.*. (1994). In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T½ cells transformed by X-rays. Cancer Research, 54, 3173-3178.
  • Paquette, B. and Little, J.B.*. (1992). Genomic rearrangements in mouse C3H/10T½ cells transformed by X-rays, UV-C and 3-methylcholanthrene by a DNA fingerprint assay. Cancer Research, 52, 5788-5793.
  • Boyle, W.R., Paquette, B. and van Lier, J.E. (1992). in vivoBiological activities of phthalocyanines - XIV. Effect of hydrophobic phthalimidomethyl groups on the phototoxicity and mechanism of photodynamic action of sulphonated aluminium phthalocyanines. British Journal of Cancer, 65, 813-817.
  • Paquette, B., Ali, H. and van Lier, J.E.*. (1991). Phtalocyanines pour la thérapie photodynamique du cancer: Effet de substituants tertio-butyles sur l'accumulation cellulaire et l'activité photodynamique de gallium sulfonate phtalocyanines. Journal de Chimie Physique, 88, 1113-1123. (Article publié).
  • Paquette, B., Rousseau, J., Ouellet, R. and van Lier, J.E.*. (1991). Radiolabeled red blood cells for direct measurement of the blood flow kinetics in experimental tumors after photodynamic therapy. Proc. SPIE-Int. Soc. Opt. Eng, ., 1426.
  • Paquette, B., Boyle, R.W., Ali, H., MacLennan, A.H., Truscott, T.G. and van Lier, J.E.*. (1991). in vitroSulfonated phthalimidomethyl aluminum phthalocyanine: the effect of hydrophobic substituents on the phototoxicity of phthalocyanines. Photochemistry and Photobiology, 53, 323-327.
  • Paquette, B., Ali, H., Langlois, R. and van Lier, J.E.*. (1990). Biological activities of phthalocyanines - XI. Phototoxicity of sulfonated aluminum naphthalocyanines towards V-79 Chinese hamster cells. Photochemistry and Photobiology, 51, 313-317.
  • Paquette, B., Ouellet, R., Langlois, R. and van Lier, J.E.*. (1990). Effect of axial ligands and macroring substituents on the photosensitizing properties of phthalo- and naph­thalocyanines. Proc. SPIE-Int. Soc. Opt. Eng., 1203, 246-253.
  • van Lier, J.E., Rousseau, J., Paquette, B., Brasseur, N., Langlois, R. and Ali, H. (1989). Tumor uptake and photodynamic activity of sulfonated metallo phthalocyanines. Proc. SPIE-Int. Soc. Opt. Eng, 1065, 138-145. (Article publié).
  • Paquette, B., Ali, H., Langlois, R. and van Lier, J.E.*. (1988). Biological activities of phthalocyanines - VIII. Cellular distribution in V-79 Chinese hamster cells and phototoxicity of selectively sulfonated aluminum phthalocyanines. Photochemistry and Photobiology, 47, 215-220.
  • Ali, H., Langlois, R., Wagner, J.R., Brasseur, N., Paquette, B. and van Lier, J.E. (1988). Biological activities of phthalocyanines - X. Syntheses and analyses of sulfonated phthalocyanines. Photochemistry and Photobiological, 47, 713-717.

Chapitres de livre

  • Cantin, A.M. and Paquette, B. (2011). Oxidants and antioxidants in lung injury: potential links with LAM. LAM and Other Diseases Characterized by Smooth Muscle Proliferation (517-531). Marcel Dekker. (Article publié).
  • Gabriel Charest, Benoit Paquette, David Mathieu. (2011). Preclinical applications of gamma knife radiosurgery using small animal models. Gamma Knife Radiosurgery (157-180). Intech Open Access Publisher. (Article publié).
  • Paquette, B. and van Lier, J.E. (1991). Phthalocyanines and related compounds: Structure-activity relationships. Photodynamic Therapy: Basic Principles and Clinical Aspects (145-146). Marcel Dekker. (Article publié).
  • van Lier, J.E., Brasseur, N., Paquette, B., Wagner, J.R., Ali, H., Langlois, R. and Rousseau, J. (1988). Phthalocyanines as sensitizers for photodynamic therapy of cancer. Photosensitization (NATO ASI Series, H 15, 435-444). Springer-Verlag Berlin Heidelberg. (Article publié).

Autres contributions

Activités de collaboration internationale

  • Chercheur. (2015-2020). France. Collaboration with the team of Pr Sabine François, Institut de Recherche Biomédicales des Armées (IRBA), on the utilisation of mesenchymal stem cell to increase the tolerance of brain to radiation.

Présentations

  • (2018). Radiation-induced inflammation can modify the invasion capacity of cancer. 4th Radiobiology symposium of the International Military Radiation & Innovation Symposium. Paris, France.
  • (2018). Radiation stimulates the invasion of cancer cells and lung metastasis development in a mouse model of triple-negative breast cancer. Annual meeting of the Canadian Radiation Protection Association. Québec, Canada.
  • (2018). Rat brain region-specific sensitivity following localized irradiation. 64nd annual international meeting, Radiation Research Society. Chicago, États-Unis.
  • (2018). TNBC tumor irradiation promotes metastasis development in a mouse model: Role of the inflammatory cytokine interleukin-1β. 64nd annual international meeting, Radiation Research Society. Chicago, États-Unis.
  • (2017). Chimioradiothérapie métabolique ciblée: Administration intra-tumorale d'un émetteur de positron 18F-FLT et du 5-fluorouracile dans un modèle de cancer colorectal chez la souris. 13e Colloque International de Radiobiologie Fondamentale et Appliquée. Lyon, France.
  • (2017). Chimioradiothérapie métabolique ciblée: Administration intra-tumorale d’un émetteur de positron 18F-FLT et du 5-fluorouracile dans un modèle de cancer colorectal chez la souris. 13ème Colloque International de Radiobiologie Fondamentale et Appliquée. Lyon, France.
  • (2017). Radiation-stimulation of cancer cell invasion and lung metastasis development in a mouse model of Triple-negative breast cancer. CARO Annual Scientific Meeting, Brachytherapy and Biology. Toronto, Canada.
  • (2017). Rat brain region-specific sensitivity following localized irradiation. EACR-AACR-SIC. Florence, Italie.
  • (2017). Risque de la radiation ionisante à faibles doses. Suivi des doses de radiation d'origine médicale chez le patient : quelles stratégies et quels outils pour le Québec?. . Sherbrooke, Canada.
  • (2017). Targeted metabolic chemoradiation therapy: Intratumoral administration of 5FU and 18F-FLT positron source in a colorectal cancer mouse model. 63nd annual international meeting, Radiation Research Society. Cancun, Mexique.
  • (2016). Effet of the irradiated microenvironment on Triple-negative breast cancer cell invasion. 62nd annual international meeting, Radiation Research Society. Hawaii, États-Unis.
  • (2016). Lung metastasis formation stimulated after irradiating a triple-negative breast tumor implanted in mouse mammary gland. International Summit on Biomarkers and Therapeutic Advances in Radiation Oncology. Montréal, Canada.
  • (2016). Neuroplasticity changes in rat brain following targeted irradiation assessed by diffusion MRI tractography validated by histology and behavioral tests. 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Singapour, Singapour.
  • (2016). Radiation-induced migration and invasion of TNBC cells. Stanford University. Stanford, États-Unis.
  • (2016). Radiation can stimulate the invasiveness and lung metastasis development in a mouse model of triple negative breast cancer. 3rd International Symposium of radiobiology. Paris, France.
  • (2016). Rat brain region-specific sensitivity following localized irradiation. 62nd annual international meeting, Radiation Research Society. Hawaii, États-Unis.
  • (2016). T2*-weighted imaging and DCE-MRI as complementary tools to characterize the continuous process of radionecrosis and neovascularization. 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Singapour, Singapour.
  • (2016). Utilization of the Ferrous Sulfate (Fricke) dosimeter for evaluating the radiation absorbed dose of 18F-FDG PET radiotracer. 13th Argentina Meeting of Medical Physics and 7th Latinoamerican Meeting of Medical Physics. Cordoba, Argentine.
  • (2015). Développement des métastases chez les cancers du sein triple-négatif induit par les radiations : Rôle de la protéine de surface MT1-MMP. 12e Colloque International de Radiobiologie Fondamentale et Appliquée. Obernai, France.
  • (2015). Estimations des changements vasculaires et neuronaux dans le cerveau du rat après une irradiation ciblée par Gamma Knife. 12e Colloque International de Radiobiologie Fondamentale et Appliquée. Obernai, France.
  • (2015). Etude pré-clinique d'irradiation ciblée du cerveau chez le petit animal et imagerie des effets radio-induits. Institut Pluridisciplinaire Hubert CURIEN (IPHC). Strasbourg, France.
  • (2015). Intra-tumoral injection of gold nanoparticles to increase the radio-sensitivity of colorectal tumor in nude mice. 61th annual meeting of the Radiation Research Society. Weston, États-Unis.
  • (2015). Irradiation ciblée du cerveau du rat par Gamma Knife et imagerie des changements vasculaires et neuronaux. Centre d'études nucléaires de Bordeaux (CENBG). Gradignan, France.
  • (2015). Metastasis development stimulated by a pre-irradiation of mammary gland in an animal model of triple negative breast cancer is associated with the cell membrane protease MT1-MMP. 61th annual meeting of the Radiation Research Society. Weston, États-Unis.
  • (2015). Method for targeting small volume in rat brain irradiation by Gamma Knife and dosimetric control: towards a standardization. International Conference on Medical Physic, Radiation Protection and Radiobiology. Zurich, Suisse.
  • (2015). Neurovascular coupling assessment in rat brain following targeted Gamma Knife irradiation. 61th annual meeting of the Radiation Research Society. Weston, États-Unis.
  • (2015). Optimal timing in concomitant chemoradiation therapy of colorectal tumors in nude mouse treated with Cisplatin and Lipoplatin TM. World Congress on Medical Physics and Biomedical Engineering. Toronto, Canada.
  • (2015). Therapeutic efficiency of intratumoral administration of 5FU chemotherapeutic drug and F-FDG positron therapy for colorectal cancer. Integrating Radiobiology with Medical Physics (IBPRO). Detroit, États-Unis.
  • (2015). Tumor response induced by intratumoral injection of 5-FU chemotherapy dryg and 18F-radiolabelled compounds in a colorectal cancer mouse model. 61th annual meeting of the Radiation Research Society. Weston, États-Unis.
  • (2015). Vascular disorders induced by stereotactic radiosurgery in rat brain measured by magnetic resonance imaging. CARO Annual Scientific Meeting, Brachytherapy and Biology. Kelowna, Canada.
  • (2015). Vascular disorders measurements in the rat brain following targeted SRS using novel precise Gamma Knife irradiation method. 12th International Stereotactic Radiosurgery Society Congress. Yokohama, Japon.
  • (2014). Convection-enhanced delivery of platinum-based drugs: chemotherapy plus time-optimized radiotherapy in F98 glioma-bearing Fischer rats. 60th annual meeting of the Radiation Reasearch Society. Las Vegas, États-Unis.
  • (2014). Irradiation of mouse mammary gland stimulates the migration of triple negative breast cancer cells and development of lung metastases. Canadian Cancer Research Conference. Toronto, Canada.
  • (2014). Irradiation of mouse mammary gland stimulates the migration of triple negative breast cancer cells and development of lung metastases. 4th World Congress on Cancer Science & Therapy. Chicago, États-Unis.
  • (2014). Méthode standardisée d'irradiation ciblée au cerveau du rat par Gamma Knife basé sur des contrôles dosimétriques. AQPMC Workshop. Montréal, Canada.
  • (2014). Stimulation of triple negative breast cancer cells migration in pre-irradiated mammary gland. 60th annual meeting of the Radiation Research Society. Las Vegas, États-Unis.
  • (2013). Brain irradiation of Fisher rat promotes the infiltration of F98 glioma cells and decreases the survival time of implanted animals. MISAM 2013: Primary and Metastatic Brain Cancers: Molecular Pathways and Clinical Challenges. Montréal, Canada.
  • (2013). Conception d'une nouvelle méthode expérimentale pour mesurer les dommages à l'ADN par des électrons de basse énergie (<50 eV). 11e. Colloque International de Radiobiologie Fondamentale et Appliquée (CIRFA). Montpellier, France.
  • (2013). Effet d’une puissante impulsion laser femtoseconde au sein de systèmes d’intérêts biologiques : dommages génotoxiques induits suite à la génération de plasmas. 11e Colloque International de Radiobiologie Fondamentale et Appliquée (CIRFA). Montpellier, France.
  • (2013). Importance of the Route of Administration of Platinum Drugs to Optimize the Concomitant Treatment with Radiotherapy for Glioblastoma Implanted in the Rat Brain Fischer. Congrès annuel 2013 de l’Association canadienne de radioprotection (ACRP). Sherbrooke, Canada.
  • (2013). Importance of the route of administration of platinum drugs to optimize the concomitant treatment with radiotherapy for glioblastoma implanted in the rat brain Fischer. 27th Annual Scientific Meeting of CARO. Montréal, Canada.
  • (2013). Migration of triple negative breast cancer cells stimulated by fractionated irradiation. 27th Annual Scientific Meeting of CARO. Montréal, Canada.
  • (2013). New avenues of research to improve the efficacy of radiotherapy - Potential role of radiatin in breast cancer progression. Congrès de radio-oncologie de la province de Shandong. Shandong, Chine.
  • (2013). Paramètres biologiques pour maximiser l'effet concomitant radiation-chimiothérapie. Université de Lyon. Lyon, France.
  • (2013). Pre-irradiation of mouse mammary gland stimulates the migration breast cancer cells. Annual Scientific Meeting of Canadian Radiation Protection Association. Sherbrooke, Canada.
  • (2013). Pre-irradiation of mouse mammary gland stimulates the migration of triple negative breast cancer cells and development of lung metastases. The Canadian Cancer Research Conference. Toronto, Canada.
  • (2013). Prévention de la migration radio-induite des cellules cancéreuses du sein. 11e Colloque International de Radiobiologie Fondamentale et Appliquée (CIRFA). Montpellier, France.
  • (2013). Évaluation comparative de différents traitements (5 composés platinés en 3 routes d’administration) combinés ou non avec la radiation ionisante pour améliorer les traitements de glioblastome. Congrès de Neurochirurgie. Québec, Canada.
  • (2012). A dream beam for cancer radiotherapy based on femtosecond IR laser-filamentation. Photonics North. Montréal, Canada.
  • (2012). Comparaison of three routes of administration for 5 different platinum compounds with or without radiotherapy. 58th annual meeting of the Radiation Research Society. Puerto Rico, États-Unis.
  • (2012). Irradiation of the brain of Fisher rat promotes migration of glioma cell F98 and decreases the life expectancy of animals. 26th Annual Scientific Meeting of CARO. Ottawa, Canada.
  • (2012). Irradiation of the brain of Fisher rat promotes migration of glioma cell F98 and decreases the life expectancy of animals. 58th annual meeting of the Radiation Research Society. Puerto Rico, États-Unis.
  • (2012). New therapeutic possibilities of combined treatment of radiotherapy with cisplatin, oxaliplatin or their liposomal formulations (Lipoplatin and Lipoxal) in colorectal cancer using nude mouse xenograft. 58th annual meeting of the Radiation Research Society. Puerto Rico, États-Unis.
  • (2012). New therapeutic possibilities of combined treatment of radiotherapy with cisplatin, oxaliplatin or their liposomal formulations (Lipoplatin and Lipoxal) in colorectal cancer using nude mouse xenograft. International Society of Gastrointestinal Oncology. Arlington, États-Unis.
  • (2012). Optimization of the treatment of radiotherapy for glioblastoma brain tumor in animal model. Qial Hospital of Jinan. Jinan, Chine.
  • (2012). Pre-irradiation of Balb/c mice mammary gland increases the invasiveness of breast cancer cells and the number of lung metastases. 58th annual meeting of the Radiation Research Society. Puerto Rico, États-Unis.
  • (2012). Pre-irradiation of the mammary gland in mice increases the invasiveness of breast cancer cells and lung metastases. Annual Scientific Meeting of CARO. Ottawa, Canada.
  • (2012). Radiotherapy by Femtosecond Laser Pulse Filamentation. Integration of New Radiation Technologies in the Multi-modality Treatment Approaches in Cancer Therapy. Montréal, Canada.
  • (2012). Réveil des métastases dormantes par des cytokines inflammatoires. Journée Phare, Université de Sherbrooke. Orford, Canada.
  • (2012). Évaluation comparative de différents traitements (5 composés platinés en 3 routes d’administration) combinés ou non avec la radiation ionisante pour améliorer les traitements de glioblastome: Études in vivo. Congrès annuel de l’Association de Neurochirurgie du Québec (ANCQ). Québec, Canada.
  • (2011). Characterisation of F98 Glioma Cells Migration Implanted in Irradiated Brain of Fischer Rat. 3B Research Forum: Benchtop to bedside and back. Atlanta, États-Unis.
  • (2011). De la theorie à la pratique, la filamentation par laser femto-seconde dans l'arsenal radio-therapeutique. Journee scientifique du departement de chirurgie. Sherbrooke, Canada.
  • (2011). Filamentation of femtosecond laser pulses as a source for radiotherapy. Photonics North. Ottawa, Canada.
  • (2011). Glioblastoma treatment: comparative studies of three routes of administration, platinum formulations and combination or not with radiation. XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function & the Xth International Conference on Quantification of Brain Function with PET. Barcelona, Espagne.
  • (2011). Infiltration des cellules cancéreuses gliales dans le cerveau stimulée par les radiations dans le modèle F98 implanté chez le rat Fisher. 10ème Colloque International de Radiobiologie Fondamentale et Appliquée. Anglet, France.
  • (2011). Inflammation induced by radiation enhances breast cancer cell invasion. 16th World Congress on Advances in Oncology and Symposium on Molecular Medicine. Rhodes, Grèce.
  • (2011). Invasiveness of breast cancer cell enhanced by radiation. BIT’S 4th Annual World Cancer congress. Dalian, Chine.
  • (2011). Prévention de l'invasion radio-induite des cellules cancéreuses du sein par la chloroquine. Conférence annuelle de la Journée Phare. Orford, Canada.
  • (2011). Rôle de la MT1-MMP et du TGF-(bêta)1 dans l’augmentation radio-induite de la migration des cellules cancéreuses du sein. 10e Colloque International de Radiobiologie Fondamentale et Appliquée. Anglet, France.
  • (2011). Évaluation comparative de différents traitements (5 composés platinés en 3 routes d’administration) combinés ou non avec la radiation ionisante pour améliorer les traitements de glioblastome. 10ème Colloque International de Radiobiologie Fondamentale et Appliquée. Anglet, France.
  • (2010). Cancer invasion monitored by a cluster analysis of T2-weighted and T1-weighted images in tumor-bearing irradiated mice. Joint Annual Meeting ISMRM-ESMRMB 2010. Stockholm, Suède.
  • (2010). Characterisation of invasiveness caused by radiation on the syngeneic glioma model F98/Fischer. 14th Biennial Canadian Neuro-Oncology Meeting. Niagara-on-the-Lake, Canada.
  • (2010). Characterisation of the increase of brain cancer cells migration caused by radiation on the syngeneic glioma model F98/Fischer. 56th annual meeting of the Radiation Research Society. Maui, États-Unis.
  • (2010). Characterisation of the increase of brain cancer cells migration caused by radiation on the syngeneic glioma model F98/Fischer. 15th Annual Scientific Meeting of the Society for Neuro-Oncology. Montréal, Canada.
  • (2010). Characterisation of the increase of brain cancer cells migration caused by radiation on the syngeneic glioma model F98/Fischer. Rencontre annuelle 2010 IROC-CORI (Initiative de Recherche en Oncologie Clinique). Sherbrooke, Canada.
  • (2010). Comparative evaluation of liposomal and non-liposomal platinum drugs combined or not with radiation to improve treatment of glioblastoma implanted in rat brain. Rencontre annuelle 2010 IROC-CORI (Initiative de Recherche en Oncologie Clinique). Sherbrooke, Canada.
  • (2010). Comparative evaluation of liposomal and nonliposomal platinum compounds combined or not with concomitant focal radiation to improve treatment of glioblastoma bearing rat. 15th Annual Scientific Meeting of the Society for Neuro-Oncology (SNO). Montréal, Canada.
  • (2010). Comparative evaluation of liposomal and nonliposomal platinum drugs combined or not with concomitant radiation to improve treatment of glioblastoma implanted in rat brain. 56th annual meeting of the Radiation Research Society. Maui, États-Unis.
  • (2010). Concomitant platinum-based chemotherapy and radiation treatment for colorectal cancer: Studies on toxicity, pharmacokinetics of platinum and synergism. American Society of Clinical Oncology Annual Meeting. Chicago, États-Unis.
  • (2010). For a better treatment of brain tumour by optimizing the concomitance treatment of radiotherapy with liposomal and non liposomal platinum drugs. International Workshop on radiosensitization: From fundamental processes involved in radiosensitization to biological applications. Paris, France.
  • (2010). Glioblastoma treatment: Bypassing the toxicity of platinum compound via liposomal formulation and increasing treatment efficiency with concomitant focal radiotherapy. In vivo experiments. 14th Biennial Canadian Neuro Oncology Meeting. Niagara-on-the-Lake, Canada.
  • (2010). Les radiations ionisantes – Un stimulateur de l’invasion des cellules cancéreuses du sein. 2e Congrès International "Radiations Médicales : Recherche et Applications". Marrakech, Maroc.
  • (2010). Response of platinum-radiosensitizing agents in human colorectal cancer with true concomitant chemoradiotherapy. Rencontre annuelle 2010 IROC-CORI (Initiative de Recherche en Oncologie Clinique). Sherbrooke, Canada.
  • (2010). Response of platinum-radiosensitizing agents in human colorectal cancer with true concomitant chemoradiotherapy. 56th annual meeting of the Radiation Research Society. Maui, États-Unis.
  • (2009). Amélioration de la radiochimiothérapie pour le traitement du glioblastome chez le rat Fischer en utilisant de nouvelles formulations liposomales de composés platinés. Colloque International de Radiobiologie Fondamentale et Appliquée. Annecy, France.
  • (2009). Concomitant treatment of F98 glioma with new liposomal platinum compounds and ionizing radiation. 23nd CARO Annual Scientific Meeting. Québec, Canada.
  • (2009). Cytotoxicity and Pharmacokinetics of Four Platinum Salts in Human Colon Carcinoma Cell-Line HCT116. Clinical Oncology Research Initiatieve. Orford, Canada.
  • (2009). Cytotoxicity and Pharmacokinetics of Four Platinum Salts in Human Colon Carcinoma Cell-Line HCT116. 2009 Gastrointestinal Oncology Conference. Philadelphia, États-Unis.
  • (2009). Fricke and polymer gel dosimetry of femtosecond laser pulse filamentation and radiation chemical effects of laser irradiation on thymidine solutions. Radiation Research Society 55th Annual Meeting. Savannah, États-Unis.
  • (2009). Invasion des cellules cancéreuses du sein stimulée par les radiations. 9ème Colloque International de Radiobiologie Fondamentale et Appliquée. Annecy, France.
  • (2009). Invasion des cellules cancéreuses du sein stimulée par les radiations. Clinical Oncology Research Initiative. Orford, Canada.
  • (2009). Liposomal platinum compounds to improve the concomitant treatment of F98 glioma cells with ionizing radiation. Meeting of the Society for Neuro-Oncology (SNO) and the AANS/CNS. New Orleans, États-Unis.
  • (2009). Liposomal platinum compounds to improve the concomitant treatment of F98 glioma cells with ionizing radiation. Clinical Oncology Research Initiative. Orford, Canada.
  • (2009). New liposomal platinum compounds to improve the concomitant treatment of F98 glioma cells with ionizing radiation. 55th Annual Meeting of the Radiation Research Society. Savannah, États-Unis.
  • (2009). Prévention par un agent anti-inflammatoire de la dermatite radio-induite. 9ème Colloque International de Radiobiologie Fondamentale et Appliquée. Annecy, France.
  • (2009). Role of radiation to stimulate the proliferation and invasiveness of F98 glioma cells implanted in rat brain. Radiation Research Society 55th Annual Meeting. Savannah, États-Unis.
  • (2009). Role of radiation to stimulate the proliferation and invasiveness of F98 glioma cells implanted in rat brain. Clinical Oncology Research Initiative. Orford, Canada.
  • (2009). The invasiveness of breast cancer cell is enhanced by radiation. Montreal International Symposium on Angiogenesis and Metastasis. Montréal, Canada.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.