Lepage, Martin

Directeur de département, Faculté de médecine et des sciences de la santé
FMSS Dép. médecine nucléaire et radiobiologie

Coordonnées

Courriel


819-821-8000, poste 11867

Diplômes

(1998) Étude de la formation de résonances électroniques et de leur rôle dans la fragmentation neutre de molécules d'intérêt biologique. Doctorate (Philosophiae Doctor). Université de Sherbrooke.

(1994) Cosntruction et mise au point d'un spectromètre d'électrons. Master's Thesis (Master's Science - Masters). Université de Sherbrooke.

(1992) Bachelor's (Bachelor's). Université de Sherbrooke.

Expérience académique

(2018) Director. Université de Sherbrooke.

Présentation

Sujets de recherche

Cancer Diagnosis and Detection, Cerebral Tumors, Breast Cancer, Radiotherapy, Neurodegenerative Diseases.

Disciplines de recherche

Radiology, Biochemistry.

Mots-clés

Animal imaging, Brain metastases, Cancer imaging, Contrast agents, MRI, Perfusion, Radiation necrosis.

Recherche clinique

Oui

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2022) Director, Dept of Nuclear Medicine and Radiobiology. Université de Sherbrooke. (Distinction).
  • (2019) Co-Director. Quebec Bio-Imaging Network. (Distinction).
  • (2017) Outstanding reviewer award. Institute of Physics. (Prize / Award).
  • (2017) Assistant Director (directeur adjoint). Quebec Bio-Imaging Network. (Distinction).
  • (2016) Outsanding Reviewer Award. Institute of Phyiscs. (Prize / Award).
  • (2014) Canada Research Chair (Tier II). Canada Research Chair program. (Distinction).
  • (2014) Canada Research Chair (Tier II). Canada Research Chair program. (Distinction).
  • Co-Director. Quebec Bio-Imaging Network. (Distinction).
  • Pierre-et-Danielle-Bourgaux award. Faculté de médecine et des sciences de la santé. (Distinction).

Financement

Grant. (Awarded). Co-investigator. Development of cancer therapies targeting Myc with cell penetrating b-HLH-LZ domains. Canadian Institutes of Health Research (CIHR). Nouvelle Subvention. 868276 $ (2018-2023).

Grant. (Awarded). Co-investigator. Quantifying Brown Adipose Tissue Thermogenesis in Obesity and Type 2 Diabetes. Canadian Institutes of Health Research (CIHR). Nouvelle Subvention. 1055700 $ (2018-2023).

Grant. (Awarded). Principal Applicant. Can deep-learning algorithms identify genetic mutations or aberrant cellular signalling pathways from medical images?. Natural Sciences and Engineering Research Council of Canada (NSERC). Collaborative Research and Development. 440287 $ (2019-2022).

Grant. (Awarded). Principal Investigator. Imaging, understanding, and managing radiotherapy inflammation and radiation necrosis. Canadian Institutes of Health Research (CIHR). Project Scheme. 914175 $ (2017-2022).

Grant. (Awarded). Co-investigator. Optimiser les soins des patients atteints du cancer de la prostate résistant à la castration en utilisant une stratégie de triple traceur en imagerie moléculaire et en radiothérapie ciblée. Fonds de recherche du Québec - Santé (FRQS). Oncopole - EMC2. 1500000 $ (2018-2021).

Grant. (Awarded). Co-applicant. Réseau de bio-imagerie du Québec (RBIQ) / Quebec Bio-Imaging Network (QBIN). Fonds de recherche du Québec - Santé (FRQS). Réseaux thématiques du FRQS. 3998000 $ (2017-2021).

Grant. (Awarded). Principal Investigator. Création d’un outil informatisé pour estimer la probabilité de récurrence tumorale et de radionécrose suivant une irradiation d’une tumeur cérébrale. Fonds de recherche du Québec - Nature et technologies (FRQNT). Projet de recherche en équipe. 161589 $ (2017-2020).

Grant. (Awarded). Co-applicant. Éradiquer le cancer par l'intérieur. Fonds de recherche du Québec - Santé (FRQS). AUDACE. 126995 $ (2018-2020).

Grant. (Awarded). Co-applicant. Cannabidiol as a potential therapeutic target for mild traumatic brain injury recovery in female rats. Canadian Institutes of Health Research (CIHR). Catalyst Grant - Cannabis Research in Urgent Priority Areas. 125000 $ (2019-2020).

Grant. (Awarded). Co-applicant. Activation pharmacologique de la graisse brune chez l’humain. Fonds Institutionel de Recherche de l'Université de Sherbrooke. Merck Sharp & Dhome grants. 173095 $ (2016-2018).

Grant. (Awarded). Co-investigator. A phase I/II study in relapsing GBM of IA carboplatin chemoradiation therapy using imaging and in vitro data for planning and treatment response prediction. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Projets structurants. 75000 $ (2017-2018).

Grant. (Awarded). Co-applicant. Oncolytic Vesicular Stomatitis Virus for the treatment of non-muscle invasive bladder cancer in humanized mice. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Projets structurants. 75000 $ (2017-2018).

Grant. (Awarded). Collaborator. Développement d'un système automatisé de clamp de la température cutanée compatible à l'IRM. l’Axe d’imagerie médicale du CRCHUS et du Centre d’imagerie médicale de l’Université de Sherbrooke. Projets pilotes express. 10000 $ (2018).

Grant. (Awarded). Principal Investigator. Synthèse et validation d’un traceur TEP de l’activité microgliale. Centre de recherche du CHUS. Projets pilotes express. 9850 $ (2018).

Grant. (Awarded). Co-applicant. Combattre l’hypoxie pour un traitement personnalisé du cancer du cerveau. Fonds Institutionel de Recherche de l'Université de Sherbrooke. Merck Sharp & Dhome grants. 50000 $ (2016-2017).

Grant. (Awarded). Co-applicant. Évaluation préclinique du potentiel d’analogues du b-HLH-LZ de Mad1 comme candidats médicaments dans la lutte contre le cancer. FMSS - Université de Sherbrooke. Merck Sharp & Dhome grants. 50000 $ (2016-2017).

Grant. (Awarded). Co-applicant. Génération d'un modèle orthotopique pour élucider le rôle des facteurs génétiques et du microenvironnement tumoral dans la carcinogenèse pancréatique. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Projets structurants. 50000 $ (2016-2017).

Grant. (Awarded). Co-applicant. Mechanisms of intestinal contribution to cholesterol gallstones formation. Canadian Institutes of Health Research (CIHR). Project Grant. 100000 $ (2016-2017).

Publications

Articles de revue

  • Fortier M, Castellano CA, Croteau E, Langlois F, St-Pierre V, Vandenberghe C, Bernier M, Roy M, Descoteaux M, Whittingstall K, Lepage M, Turcotte EE, Fulop T, Cunnane SC. (2019). A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment. Alzheimer's & Dementia, 15(5), 625-634. (Published).
  • Sikpa D, Fouquet JP, Lebel R, Diamandis P, Richer M, Lepage M. (2019). Automated detection and quantification of breast cancer brain metastases in an animal model using emocratized machine learning tools. Scientific Reports, (Accepted).
  • Richard MA, Blondin D, Noll C, Lebel R, Lepage M, Carpentier AC. (2019). Determination of a pharmacokinetic model for[11C]-acetate in brown adipose tissue. European Journal of Nuclear Medicine and Molecular Imaging Research, 9(1), 31. (Published).
  • Barrière D, Midavaine É, Doré-Savard L, Kirby K, Tremblay L, Beaudoin JF, Beaudet N, Longpre JM, Lecomte R, Lepage M, Sarret P. (2019). Dichotomic effects of clinically used drugs on tumorgrowth, bone remodeling and pain management. Scientific Reports, (Accepted).
  • Masse MH, Richard MA, D'Aragon F, St-Arnaud C, Mayette M, Adhikari N, Fraser W, Carpentier A, Palanchuck S, Gauthier D, Lanthier L, Touchette M, Lamontagne A, Chenard J, Mehta S, Sansoucy Y, Croteau E, Lepage M, Lamontagne F. (2019). Early evidence of sepsis-associated hyperperfusion - A study of cerebral blood flow measured with magnetic resonance imaging arterialspin labeling in critically-ill septic patients and control subjects. Critical Care Medicine, 46(7), e663-e669. (Published).
  • Bourassa-Moreau B, Lebel R, Gilbert G, Mathieu D, Lepage M. (2019). Increased precision in the intravascular arterial inputfunction with flow compensation. Magnetic Resonance in Medicine, 82, 1782-1795. (Published).
  • Castellano C, Hudon C, Croteau E, Fortier M, St-Pierre V, Vandenberghe C, Nugent S, Tremblay S, Paquet N, Lepage M, Fulop T, Turcotte EE, Dionne IJ, Potvin O, Duchesne S, Cunnane SC. (2019). Links between metabolic an structural changes in thebrain of cognitively normal older adults: A four year longitudinal follow-up. Frontiers in Aging Neuroscience, 11, 15. (Published).
  • Constanzo J, Dumont M, Lebel R, Tremblay L, Whittingstall K, Masson-Côté L, Geha S, Sarret P, Lepage M, Paquette B, Descoteaux M. (2018). Diffusion MRI monitoring of specific structures in the irradiated rat brain. Magn. Reson. Med., 80(4), 1614-1625. (Published).
  • Croteau E, Castellano CA, Richard MA, Fortier M, Nugent S, Lepage M, Duchesne S, Whittingstall K, Turcotte EE, Bocti C, Fülöp T, Cunnane SC. (2018). Ketogenic medium chain triglycerides increase brain metabolism in Alzheimer’s disease. Journal of Alzheimer’s Disease, 64, 551–561. (Published).
  • Houde M, Schwertani A, Touil H, Desbiens L, Sarrhini O, Lecomte R, Lepage M, Gagnon H, Takai S, Pejler G, Jacques D, Gobeil F, Day R, D'Orleans-Juste P. (2018). Mouse mast cell protease 4 deletion protects heartfunction and survival after permanent myocardial infarction. Frontiers in Pharmacology, 9, 868. (Published).
  • Richard M A, Fouquet J P, Lebel R, Lepage M,. (2017). Determination of an optimal pharmacokinetic model of FET for quantitative applications in rat brain tumors. J. Nucl. Med., 58(8), 1278-1284. (Published).
  • Tricot B, Descoteaux M, Dumont M, Chagnon F, Tremblay L, Carpentier A, Lesur O, Lepage M, Lalande A. (2017). Improving the evaluation of cardiac function in rats at 7T with denoising filters: a comparison study. BMC Med Imaging, 17(1), 62. (Published).
  • Lemay R, Lepage M, Tremblay L, Therriault H, Charest G, Paquette B,. (2017). Tumor cell invasion induced by radiation in Balb/C mouseis prevented by the cox-2 inhibitor NS-398. Radiation Research, 188, 605-614. (Published).
  • Constanzo J, Masson-Côté L, Tremblay L, Fouquet JP, Sarret P, Geha S, Whittingstall K, Paquette B, Lepage M,. (2017). Understanding the continuum of radionecrosis and vascular disorders in the brain following Gamma Knife irradiation: An MRI study. Magn. Reson. Med., 78, 1420-1431. (Published).
  • M.A. Richard, J.P. Fouquet, R. Lebel, M. Lepage,. (2016). Magnetic resonance imaging-guided derivation of the input function for PET kinetic modelling. PET Clinics, 11(2), 193-202. (Published).
  • Guirault C, Cauchon N, Lepage M, Sébire G,. (2016). Perinatal arterial ischemic stroke is associated to materno-fetal immune activation and intracranial arteritis. Int. J. Mol. Sci., 17(12), 1980. (Published).
  • Poulin E , Lebel R , Croteau E , Blanchette M , Tremblay L , Lecomte R , Bentourkia M , Lepage M. (2015). Optimization of the reference region method for dual pharmacokinetic modeling using Gd-DTPA/MRI and (18)F-FDG/PET. Magnetic Resonance in Medicine, 73(2), 740-748. (Published).
  • Chagnon F, Bourgouin A, Lebel R, Bonin MA, Marsault E, Lepage M, Lesur O,. (2015). Smart imaging of acute lung injury: exploration of myeloperoxidase (MPO) activity using in vivo endoscopic confocal fluorescencemicroscopy (ECFM). American Journal of Physiology - Lung Cellular and Molecular Physiology, 309, L543-551. (Published).
  • Lebel R , Lepage M. (2014). A comprehensive review on controls in molecular imaging: lessons from MMP-2 imaging. Contrast Media & Molecular Imaging, 9(3), 187-210. (Published).
  • Croteau E , Poulin E , Tremblay S , Dumulon-Perreault V , Sarrhini O , Lepage M , Lecomte R. (2014). Arterial input function sampling without surgery in rats for positron emission tomography molecular imaging. Nuclear Medicine Communications, 35(6), 666-676. (Published).
  • Nugent S , Tremblay S , Chen KW , Ayutyanont N , Roontiva A , Castellano CA , Fortier M , Roy M , Courchesne-Loyer A , Bocti C , Lepage M , Turcotte E , Fulop T , Reiman EM , Cunnane SC. (2014). Brain glucose and acetoacetate metabolism: a comparison of young and older adults. Neurobiology of Aging, 35(6), 1386-1395. (Published).
  • Nugent S, Castellano CA, Goffaux P, Whittingstall K, Lepage M, Paquet N, Bocti C, Fulop T, Cunnane S. (2014). Glucose hypometabolism is highly localized but lowercortical thickness and brain atrophy are widespread in cognitively normal olderadults. Am. J. Physiol. Endocrinol. Metab., 306, E1315-E1321. (Published).
  • Blanchette M , Tremblay L , Lepage M , Fortin D. (2014). Impact of drug size on brain tumor and brain parenchyma delivery after a blood-brain barrier disruption. Journal of Cerebral Blood Flow and Metabolism, 34(5), 820-826. (Published).
  • Kumar S , Tong X , Dory YL , Lepage M , Zhao Y. (2013). A CO2-switchable polymer brush for reversible capture and release of proteins. Chemical communications (Cambridge, England), 49(1), 90-92. (Published).
  • Fluckiger JU , Loveless ME , Barnes SL , Lepage M , Yankeelov TE. (2013). A diffusion-compensated model for the analysis of DCE-MRI data: theory, simulations and experimental results. Physics in Medicine and Biology, 58(6), 1983-1998. (Published).
  • Doré-Savard L , Beaudet N , Tremblay L , Xiao Y , Lepage M , Sarret P. (2013). A micro-imaging study linking bone cancer pain with tumor growth and bone resorption in a rat model. Clinical & Experimental Metastasis, 30(2), 225-236. (Published).
  • Miron G, Girard M, Lepage M, Plante JS. (2013). Design and manufacturing of embedded air-muscles for amagnetic resonance imaging compatible prostate cancer binary manipulator. J. Mech. Des., 135, 011003. (Published).
  • Côté J, Savard M, Neugebauer W, Fortin D, Lepage M, Gobeil F Jr. (2013). Dual kinin B1 and B2 receptor activation provides enhanced blood-brain barrier permeability and anticancer drug delivery into brain tumors. Cancer Biology & Therapy, 14(9), 1-6. (Published).
  • Côté J , Savard M , Neugebauer W , Fortin D , Lepage M , Gobeil F. (2013). Dual kinin B1 and B2 receptor activation provides enhanced blood-brain barrier permeability and anticancer drug delivery into brain tumors. Cancer biology & therapy, 14(9), 806-811. (Published).
  • Savard A , Lavoie K , Brochu ME , Grbic D , Lepage M , Gris D , Sebire G. (2013). Involvement of neuronal IL-1beta in acquired brain lesions in a rat model of neonatal encephalopathy. Journal of Neuroinflammation, 10(1), 110. (Published).
  • Doré-Savard L , Barrière DA , Midavaine E , Bélanger D , Beaudet N , Tremblay L , Beaudoin JF , Turcotte EE , Lecomte R , Lepage M , Sarret P. (2013). Mammary Cancer Bone Metastasis Follow-up Using Multimodal Small-Animal MR and PET Imaging. Journal of Nuclear Medicine, 54(6), 944-952. (Published).
  • Bergeron JD , Deslauriers J , Grignon S , Fortier LC , Lepage M , Stroh T , Poyart C , Sébire G. (2013). White Matter Injury and Autistic-Like Behavior Predominantly Affecting Male Rat Offspring Exposed to Group B Streptococcal Maternal Inflammation. Developmental Neuroscience, 35(6), 504-515. (Published).
  • Meesat R , Belmouaddine H , Allard JF , Tanguay-Renaud C , Lemay R , Brastaviceanu T , Tremblay L , Paquette B , Wagner JR , Jay-Gerin JP , Lepage M , Huels MA , Houde D. (2012). Cancer radiotherapy based on femtosecond IR laser-beam filamentation yielding ultra-high dose rates and zero entrance dose. Proceedings of the National Academy of Sciences of the United States of America, 109(38), 15086-15087. (Published).
  • Poulin E , Lebel R , Croteau E , Blanchette M , Tremblay L , Lecomte R , Bentourkia M , Lepage M. (2012). Conversion of arterial input functions for dual pharmacokinetic modeling using Gd-DTPA/MRI and (18) F-FDG/PET. Magnetic Resonance in Medicine, 69, 781-792. (Published).
  • Shkilnyy A , Proulx P , Sharp J , Lepage M , Vermette P. (2012). Diffusion of rhodamine B and bovine serum albumin in fibrin gels seeded with primary endothelial cells. Colloids and Surfaces. B, Biointerfaces, 93, 202-207. (Published).
  • Girard S , Tremblay L , Lepage M , Sebire G. (2012). Early detection of placental inflammation by MRI enabling protection by clinically relevant IL-1Ra administration. American Journal of Obstetrics and Gynecology, 206(4), 358.e1-9. (Published).
  • Lebel R , Bonin MA , Zriba R , Radulska A , Neugebauer W , Lepage M. (2012). Impact of H-aggregation on activatable MMP-2-specific probes for optical imaging. Contrast media & molecular imaging, 7(3), 328-337. (Published).
  • Côté J , Bovenzi V , Savard M , Dubuc C , Fortier A , Neugebauer W , Tremblay L , Müller-Esterl W , Tsanaclis AM , Lepage M , Fortin D , Gobeil F. (2012). Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model. PloS one, 7(5), e37485. (Published).
  • Ceberg S , Lepage M , Bäck SA , Gustafsson H , Ceberg C. (2012). Modelling the dynamic dose response of an nMAG polymer gel dosimeter. Physics in Medicine and Biology, 57(15), 4845-4853. (Published).
  • Kumar S, Allard JF, Morris D, Dory YL, Lepage M, Zhao Y,. (2012). Near-infrared light triggered drug release from biocompatible polypeptide block copolymer micelles. Journal of Material Chemistry, 22, 7252-7257. (Published).
  • Sedaghat M , Bujold R , Lepage M. (2012). Preliminary studies on the role and reactions of tetrakis(hydroxymethyl)phosphonium chloride in polyacrylamide gel dosimeters. Physics in Medicine and Biology, 57(19), 5981-5994. (Published).
  • Meesat R , Sanguanmith S , Meesungnoen J , Lepage M , Khalil A , Jay-Gerin JP. (2012). Utilization of the ferrous sulfate (fricke) dosimeter for evaluating the radioprotective potential of cystamine: experiment and monte carlo simulation. Radiation Research, 177(6), 813-826. (Published).
  • Aubry S , Leclerc O , Tremblay L , Rizcallah E , Croteau F , Orfali C , Lepage M. (2011). 7-Tesla MR imaging of non-melanoma skin cancer samples: correlation with histopathology. Skin Research and Technology, 18(4), 413-420. (Published).
  • Tremblay NM , Hubert-Tremblay V , Bujold R , Beddar AS , Beaulieu L , Lepage M. (2011). Accurate calibration of a polymer gel dosimeter with a plastic scintillation detector. Medical Physics, 38(5), 2754-2761. (Published).
  • Dubois J , Tremblay L , Lepage M , Vermette P. (2011). Flow dynamics within a bioreactor for tissue engineering by residence time distribution analysis combined with fluorescence and magnetic resonance imaging to investigate forced permeability and apparent diffusion coefficient in a perfusion cell cultu. Biotechnology and Bioengineering, 108, 2488-2498. (Published).
  • Sedaghat M , Bujold R , Lepage M. (2011). Investigating potential physicochemical errors in polymer gel dosimeters. Physics in Medicine and Biology, 56(18), 6083-6107. (Published).
  • Lemay R , Archambault M , Tremblay L , Bujold R , Lepage M , Paquette B. (2011). Irradiation of normal mouse tissue increases the invasiveness of mammary cancer cells. International Journal of Radiation Biology, 87(5), 472-482. (Published).
  • Gibbs S , Chattopadhyaya B , Desgent S , Awad PN , Clerk-Lamalice O , Levesque M , Vianna RM , Rébillard RM , Delsemme AA , Hébert D , Tremblay L , Lepage M , Descarries L , Di Cristo G , Carmant L. (2011). Long-term consequences of a prolonged febrile seizure in a dual pathology model. Neurobiology of Disease, 43(2), 312-321. (Published).
  • Sedaghat M , Bujold R , Lepage M. (2011). Severe dose inaccuracies caused by an oxygen-antioxidant imbalance in normoxic polymer gel dosimeters. Physics in Medicine and Biology, 56(3), 601-625. (Published).
  • Kumar S, Dory Y, Lepage M, Zhao Y,. (2011). Surface-grafted stimuli-responsive block copolymer brushes for thermo-, photo- and pH-sensitive release of dye molecules. Macromolecules, 44, 7385-7393. (Published).
  • Lepage M, Jordan K. (2010). 3D dosimetry fundamentals: gels and plastics. J. Phys.: Conf. Ser., 250, 253-261. (Published).

Chapitres de livre

  • Paré G, Lebel R, Perez J, Chagnon F, Bonin MA, Bibeau C, El Naqa I, Marsault E, Lepage M, Lesur O,. (2017). Emerging applications of intra-vital smart micro-imaging: from bench-to-bedside. Méndez-Vilas A Microscopy and imaging science: practical approaches to applied research and education (120-133). Spain : Formatex Research Center. (Published).
  • Lepage M, Gochberg DF. (2011). Magnetization transfer and chemical exchange saturation transfer imaging in cancer imaging. Yankeelov TE, Pickens DR, Price RR, Quantitative MRI in Cancer (99-106). United States : CRC Press. (Published).
  • Lepage M. (2011). Molecular and cellular imaging. Yankeelov TE, Pickens DR, Price RR, Quantitative MRI in Cancer (277-288). United States : CRC Press. (Published).

Articles de conférence

  • Sikpa D, Whittingstall L, Fouquet JP, Tremblay L, Lebel R, Lepage M. (2019). Pre-existing neurovascular inflammation increases theoccurrence of brain metastases. AACR Annual Meeting 2019. (Published).
  • Richard MA, Masse MH, D'Aragon F, St-Arnaud C, Mayette M, Croteau E, Adhikari NKJ, Fraser W, Carpentier A, Palanchuck S, Gauthier D, Lanthier L, Touchette M, Lamontagne A, Chenard J, Mehta S, Sansoucy Y, Lamontagne F, Lepage M. (2018). Cerebral blood flow in a resuscitated septic shock population: an ASL study. ISMRM 26th annual meeting. (Published).
  • Charest G, Lepage M, Fortin D, Masson-Côté L, Turcotte E, Guérin B. (2018). Fighting hypoxia for personalized brain cancer therapy. Colloque Merck-FMSS. (Published).
  • Bourassa-Moreau B, Lebel R, Gilbert G, Mathieu D, Lepage M. (2018). Flow compensation in dynamic susceptibility contrast MRI for an increase in arterial input function precision. ISMRM 26th annual meeting. (Published).
  • Fouquet JP, Paquette M, Lebel R, Descoteaux M, Lepage M. (2018). On the importance of adapting compressed sensing for imageswith significant spatial phase variations. ISMRM 26th annual meeting. (Published).
  • Sikpa D, Whittingstall L, Fouquet JP, Tremblay L, Lebel R, Lepage M. (2018). Pre-existing inflammation in the brain promotes metastases invasion. ISMRM 26th annual meeting. (Published).
  • Constanzo J, Midavaine E, Lepage M, Descoteaux M, Kirby K, Fouquet J, Tremblay L, Masson-Côté L, Geha S, Longpré JM, Pouget JP, Whittingstall K, Sarret P, Paquette B. (2018). Rat brain region-specific sensitivity following localized irradiation. 64th Annual Meeting of the Radiation Research Society. (Published).
  • Paré G, Lebel R, Bonin MA, Hudson R, Lepage M, Lesur O. (2018). Validation expérimentale de sondes fluorescentes caspase3pour l’imagerie de l’apoptose pulmonaire par microendoscopie confocale. 60ième réunion annuelle du Club de Recherches Cliniques du Québec. (Published).
  • Bourassa-Moreau* B, Lebel R, Gilbert G, Lepage M. (2017). Correction of T2* effects in arterial input function of fast dynamic contrast-enhanced MRI for accurate cerebral blood flow measurement. ISMRM 24th annual meeting. (Published).
  • Constanzo J, Lepage M, Descoteaux M, Kirby K, Fouquet J, Tremblay L, Masson-Côté L, Geha S, Longpré JM, Whittingstall K, Sarret P, Paquette B. (2017). Rat brain region-specific sensitivity following localized irradiation. EACR-AACR-SIC Special Conference 2017 - The Challenges of Optimising Immuno and Targeted Therapies: from Cancer Biology to the Clinic. (Published).
  • Fouquet* JP, Tremblay L, Lepage M. (2017). T2*-weighted imaging of the mouse neurovasculature without contrast agent. ISMRM 25th annual meeting. (Published).
  • Richard MA, Fouquet JP, Tremblay L, Lebel R, Lepage M. (2016). Determination of an optimal pharmacokinetic model of FET for quantitative applications in rat brain tumors. World Molecular Imaging Congress. (Published).
  • Richard MA, Lebel R, Fouquet JP, Lepage M. (2016). MRI-guided PET image denoising using a non-local meansfilter. ISMRM 24th annual meeting. (Published).
  • Richard MA, Fouquet JP, Lebel R, Lepage M. (2016). MRI-guided PET kinetic modeling pipeline in a rat brain tumor model. 2016 IEEE Nuclear Science Symposium and Medical Imaging Conference. (Published).
  • Fouquet JP, Constanzo J, Masson-Côté L, Tremblay L, Sarret P, Geha S, Whittingstall K, Paquette B, Lepage M. (2016). T2*-weighted imaging and DCE-MRI as complementary tools to characterize the continuous process of radionecrosis and neovascularization. ISMRM 24th annual meeting. (Published).
  • Sikpa D, Lebel R, Turgeon V, Whittingstall L, Fouquet J, Bonin MA, Tremblay L, Lepage M,. (2015). Closing up on pharmacokinetic modeling – Exploring the limits of the Tofts model for DCE-MRI analysis using intravital microscopy. ISMRM 23rd annual meeting. (Published).
  • Richard MA, Turgeon V, Fouquet JP, Tremblay L, Lebel R, Lepage M,. (2015). Combined PET-MRI: is it possible to quantify FDG perfusion based on Gd-DTPA pharmacokinetics?. ISMRM 23rd annual meeting. (Published).
  • Richard MA, Turgeon V, Fouquet JP, Tremblay L, Lebel R, Lepage M. (2015). Correlating FET and Gd-DTPA perfusion for advanced pharmacokinetic modelling. 2015 World Molecular Imaging Congress. (Published).
  • Constanzo J, Lepage M, Tremblay L, Descoteaux M, Dumont M, Sarret P, Masson-Côté L, Kirby K, Geha S, Paquette B. (2015). Estimations des changements vasculaires et neuronaux dans le cerveau du rat après une irradiation ciblée par Gamma Knife. CIRFA. (Published).
  • Fouquet JP, Lebel R, Tremblay L, Lepage M,. (2015). In vivo high resolution imaging of the mouse neurovasculature. ISMRM 23rd annual meeting. (Published).
  • Whittingstall L, Fouquet JP, Sikpa D, Lebel R, Tremblay L, Lepage M. (2015). In vivo magnetic resonance imaging and microscopy of vessel permeability and endovascular inflammation using targeted microparticles of iron oxide. 2015 World Molecular Imaging Congress. (Published).
  • Constanzo J, Lepage M, Tremblay L, Descoteaux M, Kirby K, Masson-Côté L, Guillot M, Sarret P, Paquette B. (2015). Neurovascular coupling assessment in rat brain following targeted Gamma Knife irradiation. 61st annual meeting, Radiation Research Society. (Published).
  • Constanzo, J; Masson-Côté, L; Guillot, M; Tremblay, L; Lepage, M; Paquette B;. (2015). Vascular disorders induced by stereotactic radiosurgeryin rat brain measured by magnetic resonance imaging. CARO 2015 Annual Scientific Meeting, Brachytherapy and Biology. (Published).
  • Constanzo, J; Masson-Côté, L; Guillot, M; Tremblay, L; Lepage, M; Paquette B;. (2015). Vascular disorders measurements in the rat brainfollowing targeted SRS using novel precise gamma knife irradiation method. International Stereotactic Radiosurgery Society (ISRS),. (Published).
  • M. Blanchette, S. Gascon, S. Tremblay, L. Tremblay, B. Guérin, M. Lepage, R. Lecomte, D. Fortin. (2014). Does osmotic blood-brain barrier disruption allow efflux pump substrates delivery to the tumor and CNS?. Annual SNO Scientific Meeting. (Published).
  • C. Guiraut, N. Cauchon, M. Lepage, G. Sebire. (2014). Gestational inflammation and neonatal arterial ischemic stroke, a causal connection?. Thrombosis and Vascular Biology. (Submitted).
  • O. Clerk-Lamalice, L. Tremblay, M. Dumont, L. Carmant, M. Lepage, M. Descoteaux. (2014). Hippocampal fractional anisotropy changes in a cortical dysplasiaanimal model. American Society of Neuroradiology. (Published).
  • F. Chagnon, A. Bourgouin, M.A. Bonin, R. Lebel, E. Marsault, O. Lesur, M. Lepage. (2014). Molecular imaging of acute lung injury: Detection of myeloperoxidase(MPO) activity using in vivo confocal fluorescence endomicroscopy. World Molecular Imaging Congress. (Published).
  • Radulska A, Lebel R, Neugebauer W A, Lepage M,. (2013). Characterization of MPIO probes for molecular imaging of VCAM-1. World Molecular Imaging Congress. (Published).
  • C.A. Castellano, S. Nugent, S. Tremblay, M. Fortier, N. Paquet, C. Bocti, M. Lepage, E. Turcotte, T. Fulop, S.C. Cunnane. (2013). In contrast to lower brain glucose uptake, brain ketone uptake is unchanged in mild Alzheimer’s disease: A dual tracer PET study comparing 18F-FDG and 11C-acetoacetate. Clinical Trials on Alzheimer’s Disease. (Published).
  • Doré-Savard L, Barrière DA, Midavaine E, Bélanger D, Beaudet N, Tremblay L, Beaudoin JF, Turcotte EE, Lecomte R, Sarret P, Lepage M. (2013). MRI-PET applied to a novel rat model of bone cancer pain. PET/MR and SPECT/MR: New Paradigms for Combined Modalities in Molecular Imaging Conference (PSMR2013). (Published).
  • Fouquet J, Lebel R, Lepage M. (2013). Study of the link between arterial input functions of FET-PET and Gd-DTPA-MRI for pharmacokinetic modelling. PET/MR and SPECT/MR: New Paradigms for Combined Modalities in Molecular Imaging Conference (PSMR2013). (Published).
  • R. Lebel, E. Poulin, E. Croteau, M. Blanchette, L. Tremblay, R. Lecomte, M. Bentourkia, M. Lepage. (2012). Arterial input function substitution between PET and MRI for pharmacokinetic modelling. PET/MR and SPECT/MR: New Paradigms for Combined Modalities in Molecular Imaging Conference. (Published).
  • R. Lebel, E. Poulin, M. Lepage. (2012). Automatic extraction of an AIF using a novel blood-tissue equilibrium approach. ISMRM 20th annual meeting. (Published).
  • J. Côté, L. Tremblay, D. Fortin, F. Gobeil, M. Lepage. (2012). DCE-MRI and ICP-MS evaluation of biodistribution of contrast agents and chemotherapeutic agents to gliomas with a new pharmacological approach in F98 glioma cells implanted Fischer rats. ISMRM 20th annual meeting. (Published).
  • G. Miron, A. Girard, J.-S. Plante, M. Lepage. (2012). Design and Manufacturing of Embedded Pneumatic Actuators for an MRI-Compatible Prostate Cancer Binary Manipulator. Proceedings of the ASME IDETC and CIE Conference. (Published).
  • B. Tricot, M. Descoteaux, M. Lepage, O. Lesur, L. Tremblay, F. Chagnon, A. Lalande. (2012). Improvement of the evaluation of cardiac function in rats at 7T using non-local means filtering. European Society for Magnetic Resonance in Medicine and Biology (ESMRMB). (Published).
  • M. Lepage, E. Poulin, R. Lebel, E. Croteau, M. Blanchette, L. Tremblay, R. Lecomte, M. Bentourkia. (2012). Optimization of the reference region method for dual pharmacokinetic modeling using Gd-DTPA/MRI and 18F-FDG/PET. PET/MR and SPECT/MR: New Paradigms for Combined Modalities in Molecular Imaging Conference. (Published).
  • Paquette B, Meesat R, Allard JF, Belmouaddine H, Wagner JR, Jay-Gerin JP, Lepage M, Tremblay L, Tanguay-Renaud C, Dorion D, Belzile M, Houde D. (2012). Radiotherapy by femtosecond laser pulse filamentation. Integration of new radiation technologies in the multi-modality treatment approaches in cancer therapy. (Published).
  • A. Radulska, S. Ait-Mohand, V. Dumulon-Perreault, R. Lebel, R. Zriba, B. Guérin, W. A. Neugebauer, M. Lepage. (2012). Stability studies of MMP-2 specific peptides for the preparation of molecular probes. Proceedings of the 32nd European Peptide Symposium, (Published).
  • K. Surjith, X. Tong, Y.L. Dory, M. Lepage, Y. Zhao. (2012). Stimuli-responsive polymer brushes: from controlled release to switchable protein binding. 35th High Polymer Forum. (Published).
  • É. Croteau, É. Poulin, S. Tremblay, V. Dumulon-Perreault, S. Gascon, F. Bénard, M. Lepage, R. Lecomte. (2011). A non-invasive arterial blood sampling method to obtain input function in rat. SNM 2011 Annual Meeting. (Published).
  • E. Poulin, R. Lebel, E. Croteau, M. Blanchette, L. Tremblay, R. Lecomte, M. Bentourkia, M. Lepage. (2011). Combined MRI-PET pharmacokinetic modeling using Gd-DTPA and 18F-FDG. 2011 World Molecular Imaging Congress. (Published).
  • M. Bernier, M. Lepage, R. Lecomte, L. Tremblay, L. Doré-Savard, M. Descoteaux. (2011). Combining parallel multiresolution and PCA initialization for a fully automatic PET-MRI registration. ISMRM 19th annual meeting. (Published).
  • M. Blanchette, L. Tremblay, D. Fortin, M. Lepage. (2011). DCE-MRI for chemotherapy treatment planning in neuro-oncology. 2011 World Molecular Imaging Congress. (Published).
  • É. Poulin, É. Croteau, R. Lebel, L. Tremblay, R. Lecomte, M. Bentourkia, M. Lepage. (2011). Feasibility of dual pharmacokinetic modeling using Gd-DTPA/MRI and 18F-FDG/PET. ISMRM 19th annual meeting. (Published).
  • S. Aubry, O. Leclerc, L. Tremblay, E. Rizcallah, M. Lepage. (2011). IRM 7T des tumeurs cutanées non mélanocytaires: corrélation avec l'anatomo-pathologie. Journées Françaises de Radiologie. (Published).
  • R. Lebel, M.-A Bonin, R. Zriba, A. Radulska, W.A. Neugebauer, M. Lepage. (2011). In vitro characterization of MMP-2 specific probes for optical imaging. 2011 World Molecular Imaging Congress. (Published).
  • R. Lebel, M.-A. Bonin, R. Zriba, A. Radulska, W. Neugebauer, M. Lepage. (2011). New fluorescent MMP2 activable probes based on Cy5/QSY21 and the impact of their impromptu dimerization on their absorption spectra. 94th Canadian Chemistry Conference. (Published).
  • S. Girard, L. Tremblay, G. Sébire, M. Lepage. (2011). Protection of fetuses from in utero inflammation: can MRI be the solution?. ISMRM 19th annual meeting. (Published).
  • S. Kumar, X. Tong, Y. L. Dory, Y. Zhao, M. Lepage. (2011). Surface-grafted multi-stimuli-responsive block copolymer brushes for controlled release. 94th Canadian Chemistry Conference. (Published).
  • L. Doré-Savard, L. Tremblay, K. Belleville, N, Beaudet, R. Lecomte, M. Lepage, P. Sarret. (2010). Approche multimodale d’imagerie médicale pour comprendre la douleur cancéreuse. Official satellite symposium of the 13th World Congress on Pain. (Published).
  • O. Clerk-Lamalice, P. Gravel, L. Tremblay, R. Lecomte, L. Carmant, M. Lepage. (2010). Areas of susceptibility of the predisposed immature rat brain to hyperthermic seizures and resultant neurodevelopmental delay: an MRI and PET study. ISMRM-ESMRB joint annual meeting. (Published).
  • J Côté, L Tremblay, F Gobeil Jr, M Lepage, D Fortin. (2010). DCE-MRI evaluation of inducible kinin B1 receptor-mediated selective blood-brain barrier permeabilisation in F98 glioma-bearing Fischer rats with a high molecular weight contrast agent. 14th Biennial Canadian Neuro-Oncology Meeting. (Published).
  • J. Côté, L. Tremblay, D. Fortin, F. Gobeil Jr, M. Lepage. (2010). DCE-MRI evaluation of inducible kinin B1 receptor-mediated selective blood-brain barrier permeabilisation in F98 glioma-bearing Fischer rats with a high molecular weight contrast agent. ISMRM-ESMRB joint annual meeting. (Published).
  • R. Meesat, J.-F. Allard, D. Houde, L. Tremblay, A. Khalil, J.-P. Jay-Gerin, M. Lepage. (2010). Femtosecond laser pulse filamentation characterized by polymer gel dosimetry and Fricke dosimetry. IC3DDose 2010, 6th International Conference on 3D Radiation Dosimetry (J. Phys.: Conf. Ser. 250, 012076 (2010)). (Published).
  • S. Girard, L. Tremblay, G. Sebire, M. Lepage. (2010). Impact of anti-inflammatory treatment on placental and neurodevelopmental defects monitored in utero by MRI. ISMRM-ESMRB joint annual meeting. (Published).
  • M. Sedaghat, R. Bujold, M. Lepage. (2010). Impact of oxygen on the accuracy and precision of normoxic polymer gel dosimeters. IC3DDose 2010, 6th International Conference on 3D Radiation Dosimetry (J. Phys.: Conf. Ser. 250, 012017 (2010)). (Published).
  • N.M. Tremblay, V. Hubert-Tremblay, R. Bujold, L. Beaulieu, M. Lepage. (2010). Improvement in the accuracy of polymer gel dosimeters using scintillating fibers. IC3DDose 2010, 6th International Conference on 3D Radiation Dosimetry (J. Phys.: Conf. Ser. 250, 012076 (2010)). (Published).
  • R. Lebel., H. Ligeret, F. Rivault, M. Lepage, M. Massonneau. (2010). Novel EPR-based fluorescent probe for tumour imaging during radiotherapy. 2010 World Molecular Imaging Congress. (Published).
  • S. Girard, L. Tremblay, G. Sebire, M. Lepage. (2010). Region specific-alteration of blood-brain barrier development caused by prenatal exposure to inflammation. ISMRM-ESMRB joint annual meeting. (Published).
  • É. Poulin, R. Lebel, E. Croteau, R. Lecomte, M. Bentourkia, M. Lepage. (2010). The relationship between the arterial input function obtained with Gd-DTPA / MRI and 18F-FDG / PET: a new multimodality approach. 2010 World Molecular Imaging Congress. (Published).
  • L. Doré-Savard, L. Tremblay, M. Archambault, J.-F. Beaudoin, N. Beaudet, É. Turcotte, R. Lecomte, P. Sarret, M. Lepage. (2010). Towards a better understanding of bone metastatic pain: a multimodal micro-imaging approach. ISMRM-ESMRB joint annual meeting. (Published).
  • J. Côté, M. Savard, C. Dubuc, V. Bovenzi, M. Lepage, D. Fortin, F. Gobeil jr. (2010). Étude in vivo sur l’extravasation d’agents de contraste induite par l’activation des récepteurs B2 de la bradykinine dans le modèle de gliome de rat F98. 52ième réunion annuelle du Club de Recherches Cliniques du Québec. (Published).
  • Fouquet JP, Tremblay L, Deistung A, Sibgatulin R, Krämer M, Herrmann KH, Lebel R, Reichenbach JR, Lepage M. Effects of anesthetic conditions on the mouse cerebral oxygensaturation measured by QSM. ISMRM 28th annual meeting.
  • Fouquet JP, Tremblay L, Deistung A, Sibgatulin R, Krämer M, Herrmann KH, Lebel R, Reichenbach JR, Lepage M. Effects of anesthetic conditions on the mouse cerebral oxygen saturation measured by QSM. ISMRM 28th annual meeting.
  • Richard G, Noll C, Archambault M, Tremblay L, Phoenix S, Ait-Mohand S, Lebel R, Guérin B, Carpentier AC, Lepage M. Estimation of brown adipose tissue perfusion by DCE-MRI improves measurement of oxidative metabolism by 11C-acetate PET in a rat model. ISMRM 28th annual meeting.
  • Sikpa D, Fouquet JP, Tremblay L, Lebel R, Paquette B, Lepage M. Low dose brain irradiation leads to delayed neuro-inflammation. ISMRM 28th annual meeting.
  • Bourassa-Moreau B, Lebel R, Gilbert G, Mathieu D, Lepage M. Partial volume correction of the arterial input function with surrounding tissue signal for dynamic contrast enhanced MRI in the brain. ISMRM 28th annual meeting.
  • Bourassa-Moreau B, Lebel R, Benzaquen E, Labbé I, Gilbert G, Mathieu D, Lepage M. Perfusion estimates of fast dynamic contrast enhanced MRI correlates with dynamic susceptibility contrast in brain metastases follow-up. ISMRM 28th annual meeting.

Propriétés intellectuelles

Patents

  • Gobeil Fernand, Lepage Martin, Fortin David, Sabbagh Robert, Guérin Brigitte. (2015). Novel kinin-based theranostic probes for solid cancers and uses thereof. 62/184,268; PCT/CA2016/050732. Canada. (Allowed).

Autres contributions

Présentations

  • (2018). Nouvelles approches d’imagerie de métastases cérébrales en contexte préclinique et clinique. Centre Hospitalier Universitaire de Montréal. Montreal, Canada.
  • (2015). Controls in molecular imaging. World Molecular Imaging Congress. Honolulu, United States.
  • (2015). Multi-modality imaging of tumors in rodent models. Small Animal Imaging Labs (SAIL) Grand Opening Symposium. Montreal, Canada.
  • Julie Douville Sylvie Wise. (2015). Neuroscience Specialties: Imaging Applications, Novel Models, and Specialized Administration Routes for Nonclinical Testing. 36th Annual Meeting of the American College of Toxicology. Summerlin, United States.
  • (2015). Résonnance magnétique: les nouveaux développements et avenues de recherche. IUPESM 2015 World Congress on Medical Physics & Biomedical Engineering. Toronto, Canada.
  • (2015). Small animal vascular imaging for cancer research. CREATE - Medical Image Analysis Day. Sherbrooke, Canada.
  • (2014). L’imagerie multi-modale dynamique – Caractérisation de tumeurs, planification et suivi de traitements. Journée Scientifique des Étudiants. Centre de recherche sur le cancer de l’Université Laval et CHU de Québec. Quebec City, Canada.
  • (2013). Small animal imaging of cancer. Alberta Imaging Symposium. Calgary, Canada.
  • (2013). Small animal multimodality imaging applied to cancer and neurosciences. Invited lecture. Lethbridge, Canada.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.