Grignon, Sylvain

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de psychiatrie

Coordonnées

Courriel


819-821-8000, poste 25553

Diplômes

(2007) Post-doctorat (Short Course).

(2005) Post-doctorat (NIRS visiting fellowship). Harvard Medical School.

(2005) Post-doctorat (Molecular biology summer workshop). Harvard Medical School.

(1998) Post-doctorat (stage post doctoral). Georgetown University.

(1996) Doctorat (doctorat d'université). Université d'Aix-Marseille II.

(1991) Post-doctorat (diplôme d'études spécialisées). Université d'Aix-Marseille II.

(1990) Doctorat (doctorat d'état en médecine). Université d'Aix-Marseille II.

Titres de compétence

US medical licensure examination.

examen d'évaluation. Conseil médical du Canada.

Présentation

Sujets de recherche

Récepteurs et transporteurs, Schizophrénie.

Disciplines de recherche

Neurosciences.

Mots-clés

Modèles animaux, Modèles cellulaires, Recherche clinique.

Intérêts de recherche

Impact physiopathologique des perturbations du statut oxydatif dans les maladies neuropsychiatriques

Centres de recherche

Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Centre de recherche du CHUS.

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • Best Paper Award. (Distinction).
  • Prix de la meilleure affiche. (Distinction).

Publications

Articles de revue

  • Bourque J , Mendrek A , Durand M , Lakis N , Lipp O , Stip E , Lalonde P , Grignon S , Potvin S. (2013). Cannabis abuse is associated with better emotional memory in schizophrenia: A functional magnetic resonance imaging study. Psychiatry research, 214(1),
  • Deslauriers J , Larouche A , Sarret P , Grignon S. (2013). Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers. Progress in neuro-psychopharmacology & biological psychiatry, 45,
  • Potvin S , Bourque J , Durand M , Lipp O , Lalonde P , Stip E , Grignon S , Mendrek A. (2013). The neural correlates of mental rotation abilities in cannabis-abusing patients with schizophrenia: an FMRI study. Schizophrenia research and treatment, 2013,
  • Lévesque M , Potvin S , Marchand S , Stip E , Grignon S , Pierre L , Lipp O , Goffaux P. (2012). Pain perception in schizophrenia: evidence of a specific pain response profile. Pain medicine (Malden, Mass.), 13(12),
  • Lévesque M , Potvin S , Marchand S , Stip E , Grignon S , Pierre L , Lipp O , Goffaux P. (2012). Pain perception in schizophrenia: evidence of a specific pain response profile. Pain medicine (Malden, Mass.), 13(12),
  • Deslauriers J , Desmarais C , Sarret P , Grignon S. (2012). α-Lipoic Acid Interaction with Dopamine D2 Receptor-Dependent Activation of the Akt/GSK-3β Signaling Pathway Induced by Antipsychotics: Potential Relevance for the Treatment of Schizophrenia. Journal of molecular neuroscience : MN,
  • Stip E , Abdel-Baki A , Bloom D , Grignon S , Roy MA. (2011). [Long-acting injectable antipsychotics: an expert opinion from the Association des médecins psychiatres du Québec]. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 56(6),
  • Deslauriers J , Lefrançois M , Larouche A , Sarret P , Grignon S. (2011). Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y neuroblastoma cells. Synapse (New York, N.Y.), 65(4),
  • Stip E, Abdel-Baki A, Bloom D, Grignon S, Roy MA. (2011). Long-acting injectable antipsychotics: an expert opinion from the Association des médecins psychiatres du Québec]. Can J Psychiatry, 56(6), 367-376. (Article publié).
  • Potvin S , Larouche A , Normand E , de Souza JB , Gaumond I , Marchand S , Grignon S. (2010). No relationship between the ins del polymorphism of the serotonin transporter promoter and pain perception in fibromyalgia patients and healthy controls. European journal of pain (London, England), 14(7),
  • Elie D , Poirier M , Chianetta J , Durand M , Grégoire C , Grignon S. (2010). Cognitive effects of antipsychotic dosage and polypharmacy: a study with the BACS in patients with schizophrenia and schizoaffective disorder. Journal of psychopharmacology (Oxford, England), 24(7),
  • Roy-Desruisseaux J , Grignon S. (2010). Protracted, dose-dependent weight loss after addition of ziprasidone to a stable regimen of clozapine. Human psychopharmacology, 25(5),
  • Haslam J , Pépin G , Bourbonnais R , Grignon S. (2010). Processes of task performance as measured by the Assessment of Motor and Process Skills (AMPS): A predictor of work-related outcomes for adults with schizophrenia?. Work (Reading, Mass.), 37(1),
  • Potvin S , Larouche A , Normand E , de Souza JB , Gaumond I , Grignon S , Marchand S. (2009). DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls. The journal of pain : official journal of the American Pain Society, 10(9),
  • Potvin S, Grignon S, Marchand S. (2009). Human evidence of a supra-spinal modulating role of dopamine on pain perception. Synapse, 63(5), 390-402. (Article publié).
  • Chianetta JM , Lefebvre M , LeBlanc R , Grignon S. (2008). Comparative psychometric properties of the BACS and RBANS in patients with schizophrenia and schizoaffective disorder. Schizophrenia research, 105(1-3),
  • Goulet K , Grignon S. (2008). Case report: clozapine given in the context of chemotherapy for lung cancer. Psycho-oncology, 17(5),
  • Grignon S , Forget K , Durand M , Huppert T. (2008). Increased left prefrontal activation during staring/mutism episodes in a patient with resistant catatonic schizophrenia: a near infrared spectroscopy study. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 21(1),
  • Larouche A , Berube P , Sarret P , Grignon S. (2008). Subacute H2O2, but not poly(IC), upregulates dopamine D2 receptors in retinoic acid differentiated SH-SY5Y neuroblastoma. Synapse (New York, N.Y.), 62(1),
  • Marchand J , Grignon S. (2007). A case-control study of patients with resistant schizophrenia after clozapine discontinuation. Journal of clinical psychopharmacology, 27(1),
  • Grignon S, Chianetta JM. (2007). Assessment of malondialdehyde levels in schizophrenia: a meta-analysis and some methodological considerations. Prog Neuropsychopharmacol Biol Psychiatry, 31(2), 365-369. (Article publié).
  • Potvin S, Grignon S. (2007). Dopamine et douleur: une revue de littérature. Douleur et Analgésie, 20, 246-256. (Article publié).
  • Grignon S , Trottier M. (2005). Capgras syndrome in the modern era: self misidentification on an ID picture. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 50(1),
  • Grignon S, Brethes JI, Chamberland M, Guimaraes DB. (2005). Incipient neuroleptic malignant syndrome with quetiapine/paroxetine combination treatment: atypical presentation and early, successful rechallenge with olanzapine. International Journal of Psychiatry in Clinical Practice, 9, 296-298. (Article publié).
  • Grignon S , Bassiri D , Bartoli JL , Calvet P. (1999). Association of Diogenes syndrome with a compulsive disorder. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 44(1),
  • Grignon S , Levy N , Couraud F , Bruguerolle B. (1996). Tyrosine kinase inhibitors and cycloheximide inhibit Li+ protection of cerebellar granule neurons switched to non-depolarizing medium. European journal of pharmacology, 315(1),
  • Jacob D , Grignon S , Attolini L , Gantenbein M , Bruguerolle B. (1996). Effects of calcium antagonists on binding of local anesthetics to plasma proteins and erythrocytes in mice. Pharmacology, 53(4),
  • Jeanningros R , Serres F , Dassa D , Azorin JM , Grignon S. (1996). Red blood cell L-tryptophan uptake in depression: kinetic analysis in untreated depressed patients and healthy volunteers. Psychiatry research, 63(2-3),
  • Andre MH , Grignon S , Bruguerolle B. (1996). Circadian phase dependent pharmacokinetics of L-dopa, its main metabolites (3-OMD, HVA, DOPAC) and carbidopa in rats. Fundamental & clinical pharmacology, 10(4),
  • Romain JL , Dermain P , Greslé P , Grignon S , Moisan P , Nore D , Pech G , Benyaya J , Perret I. (1996). [Efficacy of zuclopenthixol acetate on psychotic anxiety evaluated in an open study]. L'Encéphale, 22(4),
  • Grignon S, Bruguerolle B. (1996). Cerebellar lithium toxicity: a review of recent literature and tentative pathophysiology. Therapie, 51(2), 101-106. (Article publié).
  • Bruguerolle B, Grignon S. (1996). Chronopharmacology. Pathol Biol (Paris), 44(6), (Article publié).
  • Attolini L , Gantenbein M , Grignon S , Bruguerolle B. (1995). Effects of clonidine pretreatment on the local anaesthetic activity of bupivacaine in mice. The Journal of pharmacy and pharmacology, 47(12A),
  • Davous P, Auquier P, Grignon S, Neukirch H.C. (1995). A prospective study of depression in french patients with Parkinson’s disease: the DEPAR study. European Journal of Neurology, 2(5), 455-461. (Article publié).
  • Grignon S , Seagar MJ , Couraud F. (1993). Omega-conotoxin sensitive calcium channels in cerebellar granule cells are not coupled to [3H]glutamate release. Neuroscience letters, 155(1),
  • Bottai T , Levy C , Lancon C , Azorin JM , Grignon S , Valli M , Jadot G , Tissot R. (1991). [Plasma MHPG, peripheral noradrenergic marker and hormonal plasma levels of cortisol-T3-T4-TSH in depressive syndromes]. L'Encéphale, 17(3),
  • Rodor F , Bianchi G , Grignon S , Samuelian JC , Jouglard J. (1990). [Recurrent psychiatric manifestations during malaria prevention with mefloquine. A case report]. Thérapie, 45(5),
  • Jeanningros R , Grignon S , Giusiano B , Tissot R. (1989). [Changes in the kinetics of erythrocyte membrane transport of tryptophan in depression]. L'Encéphale, 15(2),

Chapitres de livre

  • Marchand S,Saravane D,Gaumond I. (2012). Douleur et schizophrénie : une perspective psychiatrique. Santé mentale et douleur Springer. (Article publié).
  • Llorca PM. (2001). Aspects étiopathogéniques de la schizophrénie. Les Psychoses John Libbey Eurotxt. (Article publié).
  • Tramoni AV. (1997). Les enjeux du diagnostic génétique en psychiatrie. Ethique Médicale et Psychiatrie Masson. (Article publié).

Autres contributions

Présentations

  • (2011). Implications hormonales dans la prédisposition à la psychose dans les troubles de l’humeur. 3ème journée du groupe de neurobiologie translationnelle en santé mentale. Montréal.
  • (2011). Neurochemical abnormalities in synergistic disruption of prepulse inhibition by prenatal immune challenge and restraint stress. Society for Neuroscience 41st Annual Meeting. Washington.
  • (2011). Suicide-related behaviors induced by social isolation in a model of schizophrenia. Society for Neuroscience 41st Annual Meeting. Washington.
  • (2011). Schizophrenia and oxidative phenomenas. Neurotalk 2011. Dalian.
  • (2011). Synergistic disruption of prepulse inhibition by prenatal immune challenge and restraint stress. International Congress on Schizophrenia Research. Colorado Springs.
  • (2010). In vitro involvement of Akt/GSK-3 signaling pathway in antipsychotics-induced dopamine D2 receptors up-regulation. Society for Neuroscience 40th Annual Meeting. San Diego.
  • (2010). Modulation glutamatergique et psychose. 2ème journée du groupe de neurobiologie translationnelle en santé mentale. Québec.
  • (2010). In vitro prevention, by -estradiol, of haloperidol-induced dopamine D2 receptors up-regulation. American Society for Neurochemistry 41st meeting. Sante Fe.
  • (2010). Oxidative phenomena underlying antipsychotics-induced dopamine D2 receptors up-regulation. American Society for Neurochemistry 41st meeting. Sante Fe.
  • (2009). Correlates of DRD2 and Sp1 mRNA expression in stable, medicated patients with schizophrenia. Society for Neuroscience 39th Annual Meeting. Chicago.
  • (2009). In vitro upregulation of dopamine D2 receptors by haloperidol, but not amisulpride, and its prevention by lipoic acid. Society for Neuroscience 39th Annual Meeting. Chicago.
  • (2009). No relationship between the INS/DEL polymorphism of the promoter region of the serotonin transporter gene and thermal pain perception and modulation in humans. Society for Neuroscience 39th Annual Meeting. Chicago.
  • (2009). Indices oxydatifs dans les troubles de l’humeur. 1ère journée du groupe de neurobiologie translationnelle en santé mentale. Montréal.
  • (2008). Correlates of dopamine D2 receptor and Sp1 transcription factor expression in lymphocytes of stable patients with schizophrenia and schizo-affective disorder. Society for Neuroscience 38th Annual Meeting. Washington.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.