Bachand, François

Professeur, Faculté de médecine et des sciences de la santé
FMSS Dép. de biochimie et de génomique fonction.

Coordonnées

Courriel


819-821-8000, poste 72733


Site Web

Diplômes

(2005) Post-doctorate (Research Fellow). Dana Farber Cancer Institute.

(2002) Doctorate (Doctorate in Cell Biology). McGill University.

(1998) Master's Thesis (Master's of Science - Masters). Université de Montréal.

(1996) Bachelor's (Bachelor's of Science). McGill University.

Présentation

Sujets de recherche

Cell, Functional and Structural Proteomics, Gene Regulation and Expression, Genomics, Molecular Genetics.

Disciplines de recherche

Genetics, Molecular Biology.

Mots-clés

Gene Regulation, Genomics, Polyadenylation, Proteomics, Ribosomal proteins, Ribosome, RNA-binding proteins, RNA decay, Yeast genetics.

Intérêts de recherche

Protein methylation has emerged as a modification important for gene regulation. However, the biological role of protein methyltransferases and the functional consequences of protein methylation remain poorly understood. The long-term goal of our research program is to further the understanding of how protein methylation modulates critical aspects of RNA maturation and ribonucleoprotein assembly.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • Alumni of the year. (Distinction).
  • Canada Research Chair in Quality Control of Gene Expression. (Prize / Award).
  • Career Development Award. (Prize / Award).
  • Maud Menten New Investigator Prize. (Distinction).
  • Prix Pierre-et-Danielle Bourgaux (To a young researcher with <10 years of university life, which recognizes the significant contribution to the advancement of science). Université de Sherbrooke. (Prize / Award).
  • Robert H. Haynes Young Scientist Award in Genetics. (Prize / Award).
  • Young Scientist Award. (Distinction).

Publications

Articles de revue

  • Landry-Voyer AM, Bilodeau S, Rouleau C, Boisvert FM, BACHAND F. (2015). The human programmed cell death-like 2 (PDCD2L) protein functions in the production of Rps2-methylated small ribosomal subunits. Genes & Development, GENESDEV/2015/270082, Under Review. (Submitted).
  • Nguyen D, Grenier St-Sauveur V, Dupuis-Sandoval F, Scott M, BACHAND F. (2015). A polyadenylation-dependent 3' end maturation pathway is required for the synthesis of the human telomerase RNA. Cell Reports, MS# D-15-02283R1, (Accepted).
  • Lemay JF, BACHAND F. (2015). Fail-safe transcription termination: Because one is never enough. RNA Biology, 12, 927-32. (Published).
  • Bergeron D, Pal G, Beaulieu YB, Chabot B and BACHAND F. (2015). Regulated intron retention and nuclear pre-mRNA decay contribute to PABPN1 autoregulation. Mol. Cell. Biol, 35, 2503-17. (Published).
  • Bitton DA, Atkinson SR, Rallis C, Smith GC, Ellis DA, Chen YY, Malecki M, Codlin S, Lemay JF, Cotobal C, BACHAND F, Marguerat S, Mata J, Bähler J. (2015). Widespread exon-skipping triggers degradation by nuclear RNA surveillance in fission yeast. Genome Research, 25, 884-96. (Published).
  • Lemay JF, Larochelle M, Marguerat S, Atkinson S, Bahler J, BACHAND F. (2014). The RNA Exosome Promotes Transcription Termination of backtracked RNA Polymerase II. Nature Struc. Mol. Biol., 21, 919-926. (Published).
  • Grenier St-Sauveur V, Soucek S, Corbett AH, BACHAND F. (2013). Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay. Mol. Cell. Biol, 33, 4718-4731. (Published).
  • Mallet PL, BACHAND F. (2013). A proline-tyrosine nuclear localization signal (PY-NLS) is required for the nuclear import of fission yeast PAB2, but not of human PABPN1. Traffic, 14, 282-294. (Published).
  • Beaulieu YB , Kleinman CL , Landry-Voyer AM , Majewski J , BACHAND F. (2012). Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1. PLoS Genetics, 8(11), e1003078. (Published).
  • Larochelle M , Lemay JF , BACHAND F. (2012). The THO complex cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression. Nucleic Acids Research, 40(20), 10240-10253. (Published).
  • Lemieux C , Marguerat S , Lafontaine J , Barbezier N , Bähler J , BACHAND F. (2011). A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein. Molecular Cell, 44(1), 108-119. (Published).
  • St-André O , Lemieux C , Perreault A , Lackner DH , Bähler J , BACHAND F. (2010). Negative regulation of meiotic gene expression by the nuclear poly(A)-binding protein in fission yeast. The Journal of Biological Chemistry, 285(36), 27859-68.
  • Lemay JF , Lemieux C , St-André O , BACHAND F. (2010). Crossing the borders: poly(A)-binding proteins working on both sides of the fence. RNA Biology, 7(3), 291-5.
  • Lemay JF , D'Amours A , Lemieux C , Lackner DH , St-Sauveur VG , Bähler J , BACHAND F. (2010). The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs. Molecular Cell, 37(1), 34-45.
  • Lemieux C , BACHAND F. (2009). Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs. Nucleic acids research, 37(10), 3418-30.
  • Perreault A , Gascon S , D'Amours A , Aletta JM , BACHAND F. (2009). A methyltransferase-independent function for Rmt3 in ribosomal subunit homeostasis. The Journal of biological chemistry, 284(22), 15026-37.
  • Perreault A , Bellemer C , BACHAND F. (2008). Nuclear export competence of pre-40S subunits in fission yeast requires the ribosomal protein Rps2. Nucleic acids research, 36(19), 6132-42.
  • Houchens CR , Perreault A , BACHAND F, Kelly TJ. (2008). Schizosaccharomyces pombe Noc3 is essential for ribosome biogenesis and cell division but not DNA replication. Eukaryotic cell, 7(9), 1433-40.
  • Bachand F. (2007). Protein arginine methyltransferases: from unicellular eukaryotes to humans. Eukaryotic cell, 6(6), 889-98.
  • Perreault A , Lemieux C , Bachand F. (2007). Regulation of the nuclear poly(A)-binding protein by arginine methylation in fission yeast. The Journal of biological chemistry, 282(10), 7552-62.
  • Bachand F* , Lackner DH , Bähler J , Silver PA. *corresponding author. (2006). Autoregulation of ribosome biosynthesis by a translational response in fission yeast. Molecular and cellular biology, 26(5), 1731-42.
  • Yu MC , Bachand F , McBride AE , Komili S , Casolari JM , Silver PA. (2004). Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors. Genes & development, 18(16), 2024-35.
  • Bachand F , Silver PA. (2004). PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits. The EMBO journal, 23(13), 2641-50.
  • Bah A , Bachand F , Clair E , Autexier C , Wellinger RJ. (2004). Humanized telomeres and an attempt to express a functional human telomerase in yeast. Nucleic acids research, 32(6), 1917-27.
  • Boisvert FM , Cote J , Boulanger MC , Cleroux P , Bachand F , Autexier C , Richard S. (2002). Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. The Journal of cell biology, 159(6), 957-69.
  • Bachand F , Boisvert FM , Côté J , Richard S , Autexier C. (2002). The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein. Molecular biology of the cell, 13(9), 3192-3202.
  • Bachand F, Triki I, Autexier C. (2001). Human telomerase RNA-protein interactions. Nucleic Acids Res., 29, 3385-93.
  • Bachand F, Autexier C. (2001). Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol Cell Biol., 21, 1888-97.
  • Bachand F, Kukolj G, Autexier C. (2000). Expression of hTERT and hTR in cis reconstitutes and active human telomerase ribonucleoprotein. RNA, 6, 778-84. (Published).
  • Bachand F, Autexier C. (1999). Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiae. J Biol Chem., 274, 38027-31.
  • Bachand F, Yao XJ, Hrimech M, Rougeau N, Cohen EA. (1999). Incorporation of Vpr into human immunodeficiency virus type 1 requires a direct interaction with the p6 domain of the p55 gag precursor. J Biol Chem., 274, 9083-91. (Published).

Chapitres de livre

  • Landry-Voyer AM, Bachand F. (2015). Control of Ribosomal Protein Expression in Yeast and Humans. RNA-binding proteins in development and diseases (Re-Edition). Research Signpost. (Submitted).

Articles de conférence

  • Duy Nguyen, Valérie Grenier St-Sauveur, Danny Bergeron, Fabien Dupuis-Sandoval, Michelle S. Scott, and François Bachand. (2015). A polyadenylation-dependent 3’ end maturation pathway is required for the synthesis of the human telomerase RNA (oral presentation). Annual Ribo-Club meeting. (Published).
  • Jean-François Lemay, Samuel Marguerat, Marc Larochelle, Rob van Nues, Xiaochuan Lin, Sander Granneman, Bin Tian, Jürg Bähler & François Bachand. (2015). Seb1 is a novel factor required for co-transcriptinal 3' end processing of coding and noncoding RNAs (oral presentation). Cold Spring Harbor Meeting on Eukaryotic mRNA processing. (Published).
  • Gheorghe Pal*, Danny Bergeron*, Yves Beaulieu, and Francois Bachand. (2014). Auto-regulation of PABPN1 expression via pre-mRNA decay in human cells. Post-Transcriptional Gene Regulation - Gordon Research Conference. (Published).
  • Anne-Marie Landry-Voyer, Sarah Bilodeau, Caroline Rouleau, François-Michel Boisvert, François Bachand. (2014). PDCD2L is an RPS2-associated shuttling protein that interacts with the late small ribosomal subunit precursor. The Nineteenth Annual Meeting of the RNA Society. (Published).
  • Duy Nguyen, Valérie Grenier St-Sauveur, Francois Bachand. (2014). The Poly(A)-Binding Protein Nuclear 1 (PABPN1) and the Nuclear Exosome Promote 3′ End Maturation of the Human Telomerase RNA. The Nineteenth Annual Meeting of the RNA Society. (Published).
  • Lafontaine J. and F. Bachand. (2013). Auto-regulation of the ribosomal protein S2 (RPS2) in human cells. 14th RiboClub Annual Meeting. (Published).
  • Landry-Voyer AM, Nguyen D, Rouleau C, Boisvert FM and Bachand F. (2013). Human PRMT3 and RPS2 form an extraribosomal complex involved in ribosome biogenesis. 14th RiboClub Annual Meeting. (Published).
  • Lemay JF, Larochelle M, Marguerat S, Bahler J, and F. Bachand. (2013). The RNA exosome promotes a transcription termination pathway coupled to RNA decay. 7th International Fission Yeast Meeting. (Published).
  • Jean-François Lemay, Marc Larochelle, Samuel Marguerat, Jürg Bähler, François Bachand. (2013). The RNA exosome promotes a transcription termination pathway coupled to RNA decay. International RNA Society meeting. (Published).
  • Atkinson S, Marguerat S, Lemay JF, Bachand F, and J. Bahler. (2013). The fission yeast non-coding transcriptome (oral presentation). 7th International Fission Yeast Meeting. (Published).
  • Mallet PL and Bachand F. (2012). A PY-NLS nuclear targeting signal is required for the nuclear import of fission yeast Pab2, but not of human PABPN1. 13th Symposium on RNA Biology. (Published).
  • Grenier St-Sauveur V. and Bachand F. (2012). Antagonistic regulation of a ribosomal protein-coding gene by independent nuclear poly(A)-binding proteins in fission yeast. 13th Symposium on RNA Biology. (Published).
  • Beaulieu Y, Kleinman CL, Landry-Voyer AM, Majewski J, and Bachand F. (2012). Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1. 13th Symposium on RNA Biology. (Published).
  • Marc Larochelle, Jean-Francois Lemay, Samuel Marguerat, Jurg Bahler, Francois Bachand. (2012). The RNA exosome promotes a transcription termination pathway coupled to RNA decay. 14th RiboClub Annual Meeting. (Published).
  • Lemay JF, Larochelle M, and Bachand F. (2011). Pab2-Rrp6 competes with TRAMP-dependent core exosome degradation during the biogenesis of snoRNAs. 12th Symposium on RNA Biology. (Published).
  • Larochelle M and Bachand F. (2011). The THO complex controls snoRNA expression by promoting the co-transcriptional recruitment of the TRAMP complex. 12th Symposium on RNA Biology. (Published).
  • Lemieux C, Lafontaine J, Marguerat S, Bahler J, and F. Bachand. (2011). Control of gene expression by pre-mRNA decay (oral presentation). 6th International Fission Yeast Meeting. (Published).
  • Lemieux C, Marguerat S, Lafontaine J, Rodriguez G, Bähler J, and Bachand F. (2011). Control of gene expression by polyadenylation-dependent pre-mRNA turnover. Cold Spring Harbor meeting on Eukaryotic mRNA processing. (Published).
  • Larochelle M and Bachand F. (2011). The THO complex controls snoRNA expression by maintaining the presence of the TRAMP complex at the 3’ end of snoRNA genes. Cold Spring Harbor meeting on Eukaryotic mRNA processing. (Published).
  • Lemieux C, Marguerat S, Lafontaine J, Rodriguez G, Bähler J, and Bachand F. (2010). Control of gene expression by polyadenylation-dependent pre-mRNA turnover. 11th Anniversary Symposium on RNA Biology. (Published).
  • Mallet PL and Bachand F. (2010). Repression of retrotransponsons expression by a nuclear poly(A)-binding protein in fission yeast. 11th Anniversary Symposium on RNA Biology. (Published).
  • Bachand F. (2010). Molecular control of ribosome biogenesis by a protein arginine methyltransferase (oral presentation). FASEB summer conferences on Biological Methylation (Oral Presentation). (Published).
  • Lemieux C, Marguerat S, Lafontaine J, Rodriguez G, Bähler J, and Bachand F. (2010). Control of gene expression by polyadenylation-dependent pre-mRNA turnover (oral presentation). 4th RNA Stability Meeting. (Published).
  • St-André O, Perreault A, Lemieux C, and Bachand F. (2009). The nuclear poly(A)-binding protein controls meiotic gene expression by posttranscriptional gene regulation of a meiosis-specific noncoding RNA in fission yeast. 5th International Fission Yeast meeting. (Published).
  • St-André O, Perreault A, Lemieux C, and Bachand F. (2009). The nuclear poly(A)-binding protein controls meiotic gene expression by posttranscriptional gene regulation of a meiosis-specific noncoding RNA in fission yeast. 10th Anniversary Symposium on RNA Biology. (Published).
  • Lemay, JF, D’Amours, A, Lemieux, C, Lackner, DH, St-Sauveur, VG, Bähler, J, Bachand F. (2009). The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs (oral presentation). 10th Anniversary Symposium on RNA Biology. (Published).

Autres contributions

Présentations

  • (2015). Seb1 is novel factor required for co-transcriptional 3' end processing of coding and noncoding RNAs. Cold Spring Harbor meeting on Eukaryotic mRNA Processing (Oral presentation).
  • (2014). Nuclear surveillance of coding and noncoding transcriptomes. RiboWest 2014 10th Anniversary.
  • (2014). Nuclear surveillance of coding and noncoding transcriptomes. Seminar associated with Robert H. Haynes Young Scientist Award in Genetics. Canadian Society for Molecular Biosciences (CSMB) 57th annual meeting.
  • (2013). The RNA exosome promotes a transcription termination pathway coupled to RNA decay. EMBO Workshop - RNA 3' ends: Mechanism and Biological Functions in Eukaryotic Genomes.
  • (2012). Polyadenylation-mediated RNA decay by PABPN1 in yeast and humans. Recent Advances in OPMD Research - European Neuro-Muscular Centre.
  • (2011). INVITED SPEAKER (SEMINARS). Since 2007, I have given 16 seminars at the following Institutions - Canadian Universities: McGill, Ottawa, Montreal, UBC, Laval, York, Concordia; American Universities: Emory, Buffalo, Rochester, NIH, Chicago; EUROPE: Oxford, UCL, Institut Curie.
  • (2011). Control of Gene Expression by a pre-mRNA decay pathway. 6th International Fission Yeast Meeting (Session Chair).
  • (2010). Control of Gene Expression by a novel pre-mRNA decay pathway. 4th RNA Stability Meeting.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.