Gévry, Nicolas

Professeur, Faculté des sciences
FAC. SCIENCES Biologie

Coordonnées

Courriel


819-821-8000, poste 66013


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Diplômes

(2007) Post-doctorat (Postdoctorat). Université de Sherbrooke.

(2004) Post-doctorat (Posdoctorat). Cornell University.

(2003) Doctorat (Sciences Vétérinaire). Université de Montréal.

(1999) Maîtrise avec mémoire (Sciences Vétérinaire - Maîtrise). Université de Montréal.

(1998) Baccalauréat (Biologie). Université de Sherbrooke.

Présentation

Sujets de recherche

Apoptose et cancer, Bioinformatique, Cancer de l'appareil reproducteur, Cancer de la prostate, Cancer du sein, Cancers hormonaux-dépendants, Expression et régulation génique, Génomique, Mécanismes et dysfonctions de la reproduction.

Disciplines de recherche

Biologie cellulaire, Biologie moléculaire, Endocrinologie, Génétique.

Mots-clés

Bioinformatique, Chromatine, Génomique, Immunoprécipitation de la chromatine (ChIP), Récepteurs Nucléaires, Séquençage à haut débit, Transcription.

Intérêts de recherche

Mes intérêts de recherche sont d'améliorer les connaissances sur les mécanismes moléculaires qui gouvernent l'expression des gènes dépendants des récepteurs nucléaires dans des contextes physiologiques et pathologiques.

Centre de recherche

Aucun

Langues parlées et écrites

Anglais, Français

Prix et distinctions

  • (2017) Research Award - Junior 2. Fonds de recherche du Québec - Santé (FRQS). (Prix / Récompense).
  • (2013) Research Award - Junior 1. Fonds de recherche du Québec - Santé (FRQS). (Prix / Récompense).
  • (2006) Postdoctoral Fellowships award. Fonds de recherche du Québec - Santé (FRQS). (Prix / Récompense).
  • (2006) Postdoctoral Fellowships award. Conseil de recherches en sciences naturelles et en génie (CRSNG). (Prix / Récompense).
  • Dean`honor roll nomination. Awarded to the top 5%. Université de Montréal. (Distinction).
  • Endocrine Society Travel Award. (Distinction).

Publications

Articles de revue

  • Brunelle M, , Nordell-Markovits A, Rodrigue S, Lupien M, Jacques PE, Gevry N. (2015). The histone variant H2A.Z is an important regulator of enhancer activity. Nucleic Acids Research, (Article sous presse).
  • Bianco S, Jangal M, Garneau D, Gévry N. (2015). LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression. Oncogene, Aug 20(34), 4509-1. (Article publié).
  • Jangal M, Couture JP, Bianco S, Magnani L, Mohammed H, Gévry N. (2014). The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor α target genes. Nucleic Acids Research, 42(18), 11339-48. (Article publié).
  • Sanchez R, Schuermann Y, Gagnon-Duval L, Baldassarre H, Murphy BD, Gevry N, Agellon LB, Bordignon V, Duggavathi R. (2014). Differential abundance of IGF1, bile acids, and the genes involved in their signaling in the dominant follicle microenvironment of lactating cows and nulliparous heifers. Theriogenology, 81(6), 771-9. (Article publié).
  • Bianco S , Brunelle M , Jangal M , Magnani L , Gevry N. (2014). LRH-1 governs vital transcriptional programs in endocrine sensitive and resistant breast cancer cells. Cancer research, 81(6), 2015-25. (Article publié).
  • Nordell Markovits A, Joly Beauparlant C, Toupin D, Wang S, Droit A, Gevry N. (2013). NGS++: a library for rapid prototyping of epigenomics software tools. Bioinformatics (Oxford, England), 29(15), 1893-4. (Article publié).
  • Magnani L, Brunelle M, Gévry N, Lupien M. (2012). Chromatin landscape and endocrine response in breast cancer. Epigenomics, 4(6), 675-83. (Article publié).
  • Couture JP, Nolet G, Beaulieu E, Blouin R, Gévry N. (2012). The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes. Endocrinology, 153(12), 5796-808. (Article publié).
  • Brunelle M, Gévry N, Lupien M. (2012). Colorectal cancer is typified by enhancer specific epigenetic mutations. Médecine sciences : M/S, 28(11), 929-31. (Article publié).
  • Beshiri ML, Holmes KB, Richter WF, Hess S, Islam AB, Yan Q, Plante L, Litovchick L, Gévry N, Lopez-Bigas N, Kaelin WG Jr, Benevolenskaya EV. (2012). Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. Proceedings of the National Academy of Sciences of the United States of America, 109(45), 18499-504. (Article publié).
  • Bianco S, Gévry N. (2012). Endocrine resistance in breast cancer: from cellular signaling pathways to epigenetic mechanisms. Transcription, 3(4), 165-70. (Article publié).
  • Svotelis A, Bianco S, Madore J, Huppé G, Nordell-Markovits A, Mes-Masson AM, Gévry N. (2011). H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERα ligand dependency. EMBO journal, 30(19), 3947-61. (Article publié).
  • Svotelis A, Gévry N, Grondin G, Gaudreau L. (2010). H2A.Z overexpression promotes cellular proliferation of breast cancer cells. Cell Cycle, 9(2), 364-70. (Article publié).
  • Hardy S , Jacques PE , Gévry N , Forest A , Fortin ME , Laflamme L , Gaudreau L , Robert F. (2009). The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition. PLoS genetics, 5(10),
  • Gévry N , Hardy S , Jacques PE , Laflamme L , Svotelis A , Robert F , Gaudreau L. (2009). Histone H2A.Z is essential for estrogen receptor signaling. Genes & development, 23(13),
  • Svotelis A , Gévry N , Gaudreau L. (2009). Regulation of gene expression and cellular proliferation by histone H2A.Z. Biochemistry and cell biology = Biochimie et biologie cellulaire, 87(1),
  • Svotelis A , Gévry N , Gaudreau L. (2009). Chromatin immunoprecipitation in mammalian cells. Methods in molecular biology (Clifton, N.J.), 543,
  • Gévry N , Svotelis A , Larochelle M , Gaudreau L. (2009). Nucleosome mapping. Methods in molecular biology (Clifton, N.J.), 543,
  • Gévry N , Schoonjans K , Guay F , Murphy BD. (2008). Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues. Journal of lipid research, 49(5),
  • Gévry N , Chan HM , Laflamme L , Livingston DM , Gaudreau L. (2007). p21 transcription is regulated by differential localization of histone H2A.Z. Genes & development, 21(15),
  • Lopes FL , Desmarais J , Ledoux S , Gévry NY , Lefevre P , Murphy BD. (2006). Transcriptional regulation of uterine vascular endothelial growth factor during early gestation in a carnivore model, Mustela vison. The Journal of biological chemistry, 281(34),
  • Guillemette B , Bataille AR , Gévry N , Adam M , Blanchette M , Robert F , Gaudreau L. (2005). Variant histone H2A.Z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning. PLoS biology, 3(12),
  • Kim MY , Mauro S , Gévry N , Lis JT , Kraus WL. (2004). NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1. Cell, 119(6),
  • Gévry NY , Lopes FL , Ledoux S , Murphy BD. (2004). Aberrant intracellular cholesterol transport disrupts pituitary and ovarian function. Molecular endocrinology (Baltimore, Md.), 18(7),
  • Lopes FL , Desmarais J , Gevry NY , Ledoux S , Murphy BD. (2003). Expression of vascular endothelial growth factor isoforms and receptors Flt-1 and KDR during the peri-implantation period in the mink, Mustela vison. Biology of reproduction, 68(5),
  • Gévry NY , Lalli E , Sassone-Corsi P , Murphy BD. (2003). Regulation of niemann-pick c1 gene expression by the 3'5'-cyclic adenosine monophosphate pathway in steroidogenic cells. Molecular endocrinology (Baltimore, Md.), 17(4),
  • Ruiz-Cortés ZT , Martel-Kennes Y , Gévry NY , Downey BR , Palin MF , Murphy BD. (2003). Biphasic effects of leptin in porcine granulosa cells. Biology of reproduction, 68(3),
  • Gévry NY , Murphy BD. (2002). The role and regulation of the Niemann-Pick C1 gene in adrenal steroidogenesis. Endocrine research, 28(4),
  • Gévry N , Lacroix D , Song JH , Pescador N , Dobias M , Murphy BD. (2002). Porcine Niemann Pick-C1 protein is expressed in steroidogenic tissues and modulated by cAMP. Endocrinology, 143(2),
  • Murphy BD , Gévry N , Ruiz-Cortés T , Coté F , Downey BR , Sirois J. (2001). Formation and early development of the corpus luteum in pigs. Reproduction (Cambridge, England) Supplement, 58,

Livres

  • Brunelle M, Gevry N. (2015). Genome-wide approches to determining nucleosome occupancy in mammalian cells. (Methods in Molecular Biology). Humana Press. (Article publié).
  • Bianco S, Gevry N. (2015). Global mapping of open chromatin regulatory elements by FAIRE-seq. (Methods in Molecular Biology). Humana Press. (Article publié).
  • Gévry N, Svotelis A, Gaudreau L. (2009). Nucleosome mapping. (Methods in Molecular Biology). Humana Press. (Article publié).

Autres contributions

Cours enseignés

  • Initiation à l'endocrinologie moléculaire. END506. (2008-01-04). Université de Sherbrooke. Canada.

Les informations disponibles dans la base de données Expertus sont tirées du CV commun canadien.