Publications 2017

Guillaume Bélanger

Boissarie, P. & Bélanger, G. Short Approach toward the Nonracemic A,B,E Tricyclic Core of Calyciphylline B-Type Alkaloids. Org. Lett. (2017).

Hauduc, C. & Bélanger, G. General Approach toward Aspidospermatan-Type Alkaloids Using One-Pot Vilsmeier-Haack Cyclization and Azomethine Ylide Cycloaddition. J. Org. Chem. 82, 4703–4712 (2017).

M'Hamed Bentourkia

Farmer, M., Echenne, B., Drouin, R. & Bentourkia, M. H. Insights in Developmental Coordination Disorder. Curr Pediatr Rev (2017).

Hamdi, M., Mimi, M. & Bentourkia, M. Impact of X-ray energy on absorbed dose assessed with Monte Carlo simulations in a mouse tumor and in nearest organs irradiated with kilovoltage X-ray beams. Cancer Radiother 21, 190–198 (2017).

Hamdi, M., Mimi, M. & Bentourkia, M. Comparison between X-rays spectra and their effective energies in small animal CT tomographic imaging and dosimetry. Australas Phys Eng Sci Med 40, 29–37 (2017).

Paquette, M. et al. Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer. Oncoimmunology (2017).

Guylain Boulay

Serrano, D. et al. GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Front Immunol 8, 94 (2017).

André Cantin

Boyapelly, K. et al. Synthesis and Characterization of a Phosphate Prodrug of Isoliquiritigenin. J. Nat. Prod. 80, 879–886 (2017).

Cantin, A. M. & Hanrahan, J. W. Thymosin α1: a single drug with multiple targets in cystic fibrosis. Nat. Med. 23, 536–538 (2017).

Wong, F. H. et al. Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells. Am. J. Physiol., Cell Physiol. 2017 (2017).

Paul Charette

Sollradl, T. et al.Metal clad waveguide (MCWG) based imaging using a high numerical aperture microscope objective.Optics Express 25, 1666–1679 (2017).

Robert Day

Couture, F. et al. PACE4 Undergoes an Oncogenic Alternative Splicing Switch in Cancer. Cancer Res. (2017).

Dianati, V. et al. Rational Design of a Highly Potent and Selective Peptide Inhibitor of PACE4 by Salt Bridge Interaction with D160 at Position P3. ChemMedChem 12, 1169–1172 (2017).

Essalmani, R. et al. Thrombin activation of protein C requires prior processing by a liver proprotein convertase. J. Biol. Chem. 292, 10564–10573 (2017).

Łepek, T. et al. Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations. Eur. J. Cell Biol. (2017).

Małuch, I. et al. Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4. J. Med. Chem. 60, 2732–2744 (2017).

Panet, F. et al. PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression. Eur. J. Cell Biol. (2017).

Jean-Bernard Denault

Duclos, C., Lavoie, C. & Denault, J.-B. Caspases rule the intracellular trafficking cartel. FEBS J. 284, 1394–1420 (2017).

Duclos, C. M. et al. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov 3, 16100 (2017).

Duclos, C. M. et al. Caspases play in traffic. Cell Death Dis 8, e2636 (2017).

Martini, C., Bédard, M., Lavigne, P. & Denault, J.-B. Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase-Substrate Interaction Involving Intrinsically Disordered Regions. Biochemistry 56, 5099–5111 (2017).

Pedro D'Orléans-Juste

Jacques, D., D’Orléans-Juste, P., Magder, S. & Bkaily, G. Neuropeptide Y and its receptors in ventricular endocardial endothelial cells. Can. J. Physiol. Pharmacol. 95, 1224–1229 (2017).

Mikhail, M., Vachon, P. H., D’Orléans-Juste, P., Jacques, D. & Bkaily, G. Role of endothelin-1 and its receptors, ETA and ETB, in the survival of human vascular endothelial cells. Can. J. Physiol. Pharmacol. 95, 1298–1305 (2017).

Yves Dory

Baillargeon, P. et al. Isomorphous crystal structures of chlorodi-acetyl-ene and iododi-acetyl-ene derivatives: simultaneous hydrogen and halogen bonds on carbon-yl. Acta Crystallogr E Crystallogr Commun 73, 1175–1179 (2017).

Dianati, V. et al. Rational Design of a Highly Potent and Selective Peptide Inhibitor of PACE4 by Salt Bridge Interaction with D160 at Position P3ChemMedChem 12, 1169–1172 (2017).

Łepek, T. et al. Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations. Eur. J. Cell Biol. (2017).

Nadon, J.-F. et al. Synthesis of Gly-ψ[(Z)CF═CH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin Peptidomimetic. ACS Chem Neurosci 8, 40–49 (2017).

Pirisedigh, A. et al. Synthesis and Evaluation of a (64)Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent. Org. Lett. 19, 2018–2021 (2017).

Quémener, M., Galstian, T., Marmin, T., Laroche, V. & Dory, Y. L. Diffusion of chiral molecules and propagation of structural chirality in anisotropic liquids. Phys Rev E 95, 052701 (2017).

Susan-Resiga, D. et al. The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA. J. Biol. Chem. 292, 1573–1590 (2017).

Nathalie Faucheux

Fernández-Gutiérrez, D. et al. Biovalorization of saccharides derived from industrial wastes such as whey: a review. Reviews in Environmental Science and Biotechnology 16, 147–174 (2017).

Girard, J.-M., Tremblay, R., Faucheux, N., Heitz, M. & Deschênes, J.-S. Phycoremediation of cheese whey permeate using directed commensalism between Scenedesmus obliquus and Chlorella protothecoides. Algal Research 22, 122–126 (2017).

Hosseininasab, S., Faucheux, N., Soucy, G. & Tavares, J. R. Full range of wettability through surface modification of single-wall carbon nanotubes by photo-initiated chemical vapour deposition. Chemical Engineering Journal 325, 101–113 (2017).

Veillette, M., Giroir-Fendler, A., Faucheux, N. & Heitz, M. A biodiesel production process catalyzed by the leaching of alkaline metal earths in methanol: from a model oil to microalgae lipids. Journal of Chemical Technology and Biotechnology 92, 1094–1103 (2017).

Veillette, M., Giroir-Fendler, A., Faucheux, N. & Heitz, M. Biodiesel from microalgae lipids: from inorganic carbon to energy production. (2017).

Veillette, M., Giroir-Fendler, A., Faucheux, N. & Heitz, M. Esterification of free fatty acids with methanol to biodiesel using heterogeneous catalysts: From model acid oil to microalgae lipids. Chemical Engineering Journal 308, 101–109 (2017).

David Fortin

Chamberland, M. et al. On the Origin of Individual Functional Connectivity Variability: The Role of White Matter Architecture. Brain Connect 7, 491–503 (2017).

Chamberland, M. et al. Active delineation of Meyer’s loop using oriented priors through MAGNEtic tractography (MAGNET). Hum Brain Mapp 38, 509–527 (2017).

Garyfallidis, E. et al. Recognition of white matter bundles using local and global streamline-based registration and clustering. Neuroimage (2017).

Luc Gaudreau

Dubois, J.-C. et al. A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination. Nucleic Acids Res. (2017).

Laflamme, L., Guillemette, B. & Gaudreau, L. An Assay for Measuring Histone Variant Exchange within Nucleosomes In Vitro. Histones: Methods and Protocols 19–37 (2017).

Lashgari, A., Millau, J.-F., Jacques, P.-É. & Gaudreau, L. Global inhibition of transcription causes an increase in histone H2A.Z incorporation within gene bodies. Nucleic Acids Res. (2017).

Millau, J.-F., Guillemette, B. & Gaudreau, L. A Method for Large-Scale Screening of Random Sequence Libraries to Determine the Function of Unstructured Regions from Essential Proteins. Methods Mol. Biol. 1528, 257–275 (2017).

Schmitt, C. et al. Patterns of diversity and spatial variability of β-defensin innate immune genes in a declining wild population of tree swallows. J. Hered. (2017).

Fernand-Pierre Gendron

Arguin, G. et al. The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Sci Rep 7, 12917 (2017).

Gendron, F.-P., Placet, M. & Arguin, G. P2Y2 Receptor Functions in Cancer: A Perspective in the Context of Colorectal Cancer. Adv. Exp. Med. Biol. (2017). 

Louis Gendron

Abdallah, K. & Gendron, L. The Delta Opioid Receptor in Pain Control. Handb Exp Pharmacol (2017).

Henry, M. S., Gendron, L., Tremblay, M.-E. & Drolet, G. Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience. Neural Plast. 2017, 1546125 (2017).

Nadon, J.-F. et al. Synthesis of Gly-ψ[(Z)CF═CH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin PeptidomimeticACS Chem Neurosci 8, 40–49 (2017).

Pirisedigh, A. et al. Synthesis and Evaluation of a (64)Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent. Org. Lett. 19, 2018–2021 (2017).

St-Louis, É. et al. Involvement of the coatomer protein complex I in the intracellular traffic of the delta opioid receptor. Mol. Cell. Neurosci. 79, 53–63 (2017).

Fernand Gobeil

Regoli, D. & Gobeil, F. Kallikrein-kinin system as the dominant mechanism to counteract hyperactive renin-angiotensin system. Can. J. Physiol. Pharmacol. 1–8 (2017).

Michel Grandbois

Astruc, J. et al. Isolation of cellulose-II nanospheres from flax stems and their physical and morphological properties. Carbohydr Polym 178, 352–359 (2017).

Besserer-Offroy, É. et al. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur. J. Pharmacol. 805, 1–13 (2017).

Sollradl, T. et al. Metal clad waveguide (MCWG) based imaging using a high numerical aperture microscope objective. Optics Express 25, 1666–1679 (2017).

Brigitte Guérin

Blondin, D. P. et al. Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans. Cell Metab. (2017).

Blondin, D. P. et al. Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men. Nat Commun 8, 14146 (2017).

Mansour, N. et al. Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [(64) Cu]Cu/NOTA peptide-based gastrin-releasing peptide receptors antagonists. J Labelled Comp Radiopharm 60, 200–212 (2017).

Nadon, J.-F. et al. Synthesis of Gly-ψ[(Z)CF═CH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin PeptidomimeticACS Chem Neurosci 8, 40–49 (2017).

Osati, S., Ali, H., Guerin, B. & van Lier, J. E. Synthesis and spectral properties of estrogen- and androgen-BODIPY conjugates. Steroids 123, 27–36 (2017).

Osati, S. et al. BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities. Bioorg. Med. Chem. Lett. 27, 443–446 (2017).

Panet, F. et al. PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression. Eur. J. Cell Biol. (2017).

Paquette, M. et al. Improved Estrogen Receptor Assessment by PET Using the Novel Radiotracer 4FMFES in ER+ Breast Cancer Patients: an Ongoing Phase II Clinical Trial. J. Nucl. Med. (2017).

Paquette, M. et al. Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer. Oncoimmunology 6, (2017).

Pirisedigh, A. et al. Synthesis and Evaluation of a (64)Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent. Org. Lett. 19, 2018–2021 (2017).

Selivanova, S. V. et al. Clinical Trial with Sodium (99m)Tc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function. J. Nucl. Med. 58, 791–798 (2017).

Daniel Lafontaine

Bastet, L. et al. Translational control and Rho-dependent transcription termination are intimately linked in riboswitch regulation. Nucleic Acids Res. 45, 7474–7486 (2017).

Chauvier, A. et al. Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation. Nat Commun 8, 13892 (2017).

Dussault, A.-M., Dubé, A., Jacques, F., Grondin, J. P. & Lafontaine, D. A. Ligand recognition and helical stacking formation are intimately linked in the SAM-I riboswitch regulatory mechanism. RNA 23, 1539–1551 (2017).

Pierre Lavigne

Bédard, M., Maltais, L., Montagne, M. & Lavigne, P. Miz-1 and Max compete to engage c-Myc: implication for the mechanism of inhibition of c-Myc transcriptional activity by Miz-1. Proteins 85, 199–206 (2017).

Bédard, M., Roy, V., Montagne, M. & Lavigne, P. Structural Insights into c-Myc-interacting Zinc Finger Protein-1 (Miz-1) Delineate Domains Required for DNA Scanning and Sequence-specific Binding. J. Biol. Chem. 292, 3323–3340 (2017).

Li, X. et al. Gαs protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting. Proc. Natl. Acad. Sci. U.S.A. (2017).

Maltais, L. et al. Biophysical characterization of the b-HLH-LZ of ΔMax, an alternatively spliced isoform of Max found in tumor cells: Towards the validation of a tumor suppressor role for the Max homodimers. PLoS ONE 12, (2017).

Martini, C., Bédard, M., Lavigne, P. & Denault, J.-B. Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase-Substrate Interaction Involving Intrinsically Disordered RegionsBiochemistry 56, 5099–5111 (2017).

Christine Lavoie

Duclos, C., Lavoie, C. & Denault, J.-B. Caspases rule the intracellular trafficking cartel. FEBS J. 284, 1394–1420 (2017).

Duclos, C. M. et al. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov 3, 16100 (2017).

Duclos, C. M. et al. Caspases play in traffic. Cell Death Dis 8, e2636 (2017).

Lanchec, E. et al. The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloid. J. Biol. Chem. (2017).

Li, X. et al. Gαs protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sortingProc. Natl. Acad. Sci. U.S.A. (2017).

Serrano, D. et al. GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Front Immunol 8, 94 (2017).

St-Louis, É. et al. Involvement of the coatomer protein complex I in the intracellular traffic of the delta opioid receptor. Mol. Cell. Neurosci. 79, 53–63 (2017).

Roger Lecomte

Arguin, G. et al. The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosisSci Rep 7, 12917 (2017).

Caron, A. et al. Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue. Biochimie (2017).

Loignon-Houle, F., Bergeron, M., Pepin, C. M., Charlebois, S. A. & Lecomte, R. Simulation of scintillation light output in LYSO scintillators through a full factorial design. Phys Med Biol 62, 669–683 (2017).

Mansour, N. et al. Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [(64) Cu]Cu/NOTA peptide-based gastrin-releasing peptide receptors antagonists. J Labelled Comp Radiopharm 60, 200–212 (2017).

O’Farrell, A. C. et al. A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate. PLoS ONE 12, (2017).

Paquette, M. et al. Improved Estrogen Receptor Assessment by PET Using the Novel Radiotracer 4FMFES in ER+ Breast Cancer Patients: an Ongoing Phase II Clinical TrialJ. Nucl. Med. (2017).

Paquette, M. et al. Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancerOncoimmunology 6, (2017).

Selivanova, S. V. et al. Clinical Trial with Sodium (99m)Tc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function. J. Nucl. Med. 58, 791–798 (2017).

Richard Leduc

Besserer-Offroy, É. et al. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur. J. Pharmacol. 805, 1–13 (2017).

Lahey, K. A. et al. Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS ONE 12, (2017).

Lanchec, E. et al. The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloidJ. Biol. Chem. (2017).

Li, X. et al. Gαs protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sortingProc. Natl. Acad. Sci. U.S.A. (2017).

Murza, A. et al. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org. Biomol. Chem. 15, 449–458 (2017).

Perreault, S. et al. Older adults with heart failure treated with carvedilol, bisoprolol, or metoprolol tartrate: risk of mortality. Pharmacoepidemiol Drug Saf 26, 81–90 (2017).

Pirisedigh, A. et al. Synthesis and Evaluation of a (64)Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent. Org. Lett. 19, 2018–2021 (2017).

St-Georges, C. et al. Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids. Eur J Med Chem 129, 110–123 (2017).

Wilkinson, D. J. et al. Matriptase induces metalloproteinase-dependent aggrecanolysis in vitro and in vivo: multiple mechanisms promote cartilage damage in osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.) (2017).

Claude Legault

Basdevant, B., Guilbault, A.-A., Beaulieu, S., Lauriers, A. J.-D. & Legault, C. Y. Iodine(III)-mediated synthesis of chiral α-substituted ketones: Recent advances and mechanistic insights. Pure and Applied Chemistry 89, 781–789 (2017).

Cocaud, C. et al. Tunable Approach for the Stereoselective Synthesis of 1-C-Diethylphosphono(difluoromethyl) Iminosugars as Glycosyl Phosphate Mimics. J. Org. Chem. 82, 2753–2763 (2017).

Dagenais, R., Lauriers, A. J.-D. & Legault, C. Y. Iodine(III)-Mediated Oxidative Hydrolysis of Haloalkenes: Investigation of the Effect of Iodine(III) Reagents. Synthesis (Germany) 49, 2928–2932 (2017).

Labattut, A., Tremblay, P.-L., Moutounet, O. & Legault, C. Y. Experimental and Theoretical Quantification of the Lewis Acidity of Iodine(III) Species. J. Org. Chem. 82, 11891–11896 (2017).

Robidas, R., Guérin, V., Provençal, L., Echeverria, M. & Legault, C. Y. Investigation of Iodonium Trifluoroborate Zwitterions as Bifunctional Arene Reagents. Org. Lett. (2017). 

Martin Lepage

Constanzo, J. et al. Understanding the continuum of radionecrosis and vascular disorders in the brain following gamma knife irradiation: An MRI study. Magn Reson Med 78, 1420–1431 (2017).

Lemay, R. et al. Tumor Cell Invasion Induced by Radiation in Balb/C Mouse is Prevented by the Cox-2 Inhibitor NS-398. Radiat. Res. (2017). 

Paré, G. et al. Emerging applications of intra-vital smart micro-imaging: from bench-to-bedside. in Microscopy and imaging science: practical approaches to applied research and education. (ed. Méndez-Vilas, A.) 120–133 (Formatex Research Center, 2017).

Richard, M. A., Fouquet, J. P., Lebel, R. & Lepage, M. Determination of an Optimal Pharmacokinetic Model of (18)F-FET for Quantitative Applications in Rat Brain Tumors. J. Nucl. Med. 58, 1278–1284 (2017).

Olivier Lesur

Chagnon, F. et al. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit. Care Med. 45, e391–e398 (2017).

Coquerel, D. et al. ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock. Crit. Care Med. 45, e1139–e1148 (2017).

Murza, A. et al. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org. Biomol. Chem. 15, 449–458 (2017).

Paré, G. et al. Emerging applications of intra-vital smart micro-imaging: from bench-to-bedside. in Microscopy and imaging science: practical approaches to applied research and education. (ed. Méndez-Vilas, A.) 120–133 (Formatex Research Center, 2017).

Perez, J. R. et al. Tracking of Mesenchymal Stem Cells with Fluorescence Endomicroscopy Imaging in Radiotherapy-Induced Lung Injury. Sci Rep 7, 40748 (2017).

Jeffrey Leyton

Osati, S. et al. BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities. Bioorg. Med. Chem. Lett. 27, 443–446 (2017).

Paquette, M. et al. Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancerOncoimmunology 6, (2017).

Éric Marsault

Besserer-Offroy, É. et al. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur. J. Pharmacol. 805, 1–13 (2017).

Boyapelly, K. et al. Synthesis and Characterization of a Phosphate Prodrug of IsoliquiritigeninJ. Nat. Prod. 80, 879–886 (2017).

Chagnon, F. et al. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit. Care Med. 45, e391–e398 (2017).

Coquerel, D. et al. ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic ShockCrit. Care Med. 45, e1139–e1148 (2017).

Marsault, E. & Peterson, M. L. Practical medicinal chemistry with macrocycles : design, synthesis, and case studies. (Hoboken, New Jersey : Wiley, 2017., 2017).

Murza, A. et al. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org. Biomol. Chem. 15, 449–458 (2017).

Paquette, M. et al. Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancerOncoimmunology 6, (2017).

Paré, G. et al. Emerging applications of intra-vital smart micro-imaging: from bench-to-bedside. in Microscopy and imaging science: practical approaches to applied research and education. (ed. Méndez-Vilas, A.) 120–133 (Formatex Research Center, 2017).

St-Georges, C. et al. Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acidsEur J Med Chem 129, 110–123 (2017).

Rafaël Najmanovich

Chartier, M., Morency, L.-P., Zylber, M. I. & Najmanovich, R. J. Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects. BMC Pharmacol Toxicol 18, 18 (2017).

Chénard, T. et al. Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes. BMC Syst Biol 11, 60 (2017).

Frappier, V., Chartier, M. & Najmanovich, R. Applications of Normal Mode Analysis Methods in Computational Protein Design. Methods Mol. Biol. 1529, 203–214 (2017).

Najmanovich, R. J. Evolutionary studies of ligand binding sites in proteins. Curr. Opin. Struct. Biol. 45, 85–90 (2017).

St-Georges, C. et al. Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acidsEur J Med Chem 129, 110–123 (2017).

Jean-Luc Parent

Lucien, F. et al. Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance. Nat Commun 8, 15884 (2017).

St-Louis, É. et al. Involvement of the coatomer protein complex I in the intracellular traffic of the delta opioid receptor. Mol. Cell. Neurosci. 79, 53–63 (2017).

White, C. A. et al. β-Trace Protein Assays: A Comparison Between Nephelometric and ELISA Methodologies. Am. J. Kidney Dis. 69, 866–868 (2017).

Xavier Roucou

Delcourt, V. et al. Combined Mass Spectrometry Imaging and Top-down Microproteomics Reveals Evidence of a Hidden Proteome in Ovarian Cancer. EBioMedicine (2017).30.

Delcourt, V. et al. Top-down microproteomics bridged to MALDI MS imaging reveals the molecular physiome of brain regions. Mol. Cell Proteomics (2017). 

Delcourt, V., Staskevicius, A., Salzet, M., Fournier, I. & Roucou, X. Small proteins encoded by unannotated ORFs are rising stars of the proteome, confirming shortcomings in genome annotations and current vision of an mRNA. Proteomics (2017).

Samandi, S. et al. Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins. Elife 6, (2017).

Philippe Sarret

Besserer-Offroy, É. et al. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur. J. Pharmacol. 805, 1–13 (2017).

Chagnon, F. et al. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit. Care Med. 45, e391–e398 (2017).

Constanzo, J. et al.Understanding the continuum of radionecrosis and vascular disorders in the brain following gamma knife irradiation: An MRI study. Magn Reson Med 78, 1420–1431 (2017).

Coquerel, D. et al. ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic ShockCrit. Care Med. 45, e1139–e1148 (2017).

Fanelli, R. et al. Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues. J. Med. Chem. 60, 3303–3313 (2017).

Ferland, C. E. et al. Preoperative Norepinephrine Levels in Cerebrospinal Fluid and Plasma Correlate With Pain Intensity After Pediatric Spine Surgery. Spine Deform 5, 325–333 (2017).

Murza, A. et al. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org. Biomol. Chem. 15, 449–458 (2017).

Patrick Vermette

Andersen, P. L. & Vermette, P. Biomimetic Surfaces Supporting Dissociated Pancreatic Islet Cultures. Colloids and Surfaces B: Biointerfaces 159, 166–173 (2017).http://www.mdpi.com/2073-4360/9/6/238/htm

Dubiel, E. A., Fulop, T., Vigier, S. & Vermette, P. Quartz crystal microbalance as an assay to detect anti-drug antibodies for the immunogenicity assessment of therapeutic biologics. Analytical and Bioanalytical Chemistry 1–15 (2017).

Dubiel, E. A., Martin, B., Vigier, S. & Vermette, P. Real-time label-free detection and kinetic analysis of Etanercept—Protein A interactions using quartz crystal microbalance. Colloids and Surfaces B: Biointerfaces 149, 312–321 (2017).

Sharp, J. & Vermette, P. An In-situ glucose-stimulated insulin secretion assay under perfusion bioreactor conditions. Biotechnology Progress 33, 454–462 (2017).

Vigier, S. et al. Composition and organization of the pancreatic extracellular matrix by combined methods of immunohistochemistry, proteomics and scanning electron microscopy. Current Research in Translational Medicine 65, 31–39 (2017).

Yue Zhao

Chen, Y. et al. One-Pot Preparation of Autonomously Self-Healable Elastomeric Hydrogel from Boric Acid and Random Copolymer Bearing Hydroxyl Groups. ACS Macro Lett. 6, 1129–1133 (2017).

Dong, L., Fan, W., Zhang, H., Chen, M. & Zhao, Y. CO 2-Responsive polymer membranes with gas-tunable pore size. Chemical Communications 53, 9574–9577 (2017).

Fan, W., Tong, X., Farnia, F., Yu, B. & Zhao, Y. CO2-Responsive Polymer Single-Chain Nanoparticles and Self-Assembly for Gas-Tunable Nanoreactors. Chem. Mater. 29, 5693–5701 (2017).

Fan, W., Tong, X., Li, G. & Zhao, Y. Photoresponsive liquid crystalline polymer single-chain nanoparticles. Polymer Chemistry 8, 3523–3529 (2017).

Ge, F., Lu, X., Xiang, J., Tong, X. & Zhao, Y. An Optical Actuator Based on Gold‐Nanoparticle‐Containing Temperature‐Memory Semicrystalline Polymers. Angewandte Chemie International Edition 56, 6126–6130 (2017).

Ge, F. & Zhao, Y. A new function for thermal phase transition-based polymer actuators: autonomous motion on a surface of constant temperature. Chemical Science 8, 6307–6312 (2017).

Lu, X., Guo, S., Tong, X., Xia, H. & Zhao, Y. Tunable Photocontrolled Motions Using Stored Strain Energy in Malleable Azobenzene Liquid Crystalline Polymer Actuators. Advanced Materials 29, 1606467–n/a (2017).

Yang, R. & Zhao, Y. Non-Uniform Optical Inscription of Actuation Domains in a Liquid Crystal Polymer of Uniaxial Orientation: An Approach to Complex and Programmable Shape Changes. Angewandte Chemie 129, 14390–14394 (2017).

Yu, B., Fan, W. & Zhao, Y. Gelation of Triblock Copolymers in Aqueous Solution through CO2-Triggered Electrostatic Interaction. Macromolecular Chemistry and Physics (2017).

Yu, B. & Zhao, Y. CO 2-Responsive fluorescent hyperbranched poly (ether amine) s. Polymer Chemistry 8, 4132–4139 (2017).

Zhang, H., Guo, S., Fu, S. & Zhao, Y. A Near-Infrared Light-Responsive Hybrid Hydrogel Based on UCST Triblock Copolymer and Gold Nanorods. Polymers 9, 238 (2017).