Publications 2017

Guillaume Bélanger

Boissarie, P. & Bélanger, G. Short Approach toward the Nonracemic A,B,E Tricyclic Core of Calyciphylline B-Type Alkaloids. Org. Lett. (2017).

Hauduc, C. & Bélanger, G. General Approach toward Aspidospermatan-Type Alkaloids Using One-Pot Vilsmeier-Haack Cyclization and Azomethine Ylide Cycloaddition. J. Org. Chem. 82, 4703–4712 (2017).

M'Hamed Bentourkia

Hamdi, M., Mimi, M. & Bentourkia, M. Impact of X-ray energy on absorbed dose assessed with Monte Carlo simulations in a mouse tumor and in nearest organs irradiated with kilovoltage X-ray beams. Cancer Radiother 21, 190–198 (2017).

Hamdi, M., Mimi, M. & Bentourkia, M. Comparison between X-rays spectra and their effective energies in small animal CT tomographic imaging and dosimetry. Australas Phys Eng Sci Med 40, 29–37 (2017).

Guylain Boulay

Serrano, D. et al. GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Front Immunol 8, 94 (2017).

André Cantin

Cantin, A. M. & Hanrahan, J. W. Thymosin α1: a single drug with multiple targets in cystic fibrosis. Nat. Med. 23, 536–538 (2017).

Robert Day

Essalmani, R. et al. Thrombin activation of protein C requires prior processing by a liver proprotein convertase. J. Biol. Chem. 292, 10564–10573 (2017).

Łepek, T. et al. Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations. Eur. J. Cell Biol. (2017).

Małuch, I. et al. Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4. J. Med. Chem. 60, 2732–2744 (2017).

Panet, F. et al. PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression. Eur. J. Cell Biol. (2017).

Jean-Bernard Denault

Duclos, C., Lavoie, C. & Denault, J.-B. Caspases rule the intracellular trafficking cartel. FEBS J. 284, 1394–1420 (2017).

Duclos, C. M. et al. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov 3, 16100 (2017).

Duclos, C. M. et al. Caspases play in traffic. Cell Death Dis 8, e2636 (2017).

Yves Dory

Łepek, T. et al. Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations. Eur. J. Cell Biol. (2017).

Pirisedigh, A. et al. Synthesis and Evaluation of a (64)Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent. Org. Lett. 19, 2018–2021 (2017).

Quémener, M., Galstian, T., Marmin, T., Laroche, V. & Dory, Y. L. Diffusion of chiral molecules and propagation of structural chirality in anisotropic liquids. Phys Rev E 95, 052701 (2017).

Susan-Resiga, D. et al. The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA. J. Biol. Chem. 292, 1573–1590 (2017).

Nathalie Faucheux

Fernández-Gutiérrez, D. et al. Biovalorization of saccharides derived from industrial wastes such as whey: a review. Reviews in Environmental Science and Biotechnology 16, 147–174 (2017).

Girard, J.-M., Tremblay, R., Faucheux, N., Heitz, M. & Deschênes, J.-S. Phycoremediation of cheese whey permeate using directed commensalism between Scenedesmus obliquus and Chlorella protothecoides. Algal Research 22, 122–126 (2017).

Hosseininasab, S., Faucheux, N., Soucy, G. & Tavares, J. R. Full range of wettability through surface modification of single-wall carbon nanotubes by photo-initiated chemical vapour deposition. Chemical Engineering Journal 325, 101–113 (2017).

Veillette, M., Giroir-Fendler, A., Faucheux, N. & Heitz, M. A biodiesel production process catalyzed by the leaching of alkaline metal earths in methanol: from a model oil to microalgae lipids. Journal of Chemical Technology and Biotechnology 92, 1094–1103 (2017).

Veillette, M., Giroir-Fendler, A., Faucheux, N. & Heitz, M. Biodiesel from microalgae lipids: from inorganic carbon to energy production. (2017).

Veillette, M., Giroir-Fendler, A., Faucheux, N. & Heitz, M. Esterification of free fatty acids with methanol to biodiesel using heterogeneous catalysts: From model acid oil to microalgae lipids. Chemical Engineering Journal 308, 101–109 (2017).

David Fortin

Chamberland, M. et al. Active delineation of Meyer’s loop using oriented priors through MAGNEtic tractography (MAGNET). Hum Brain Mapp 38, 509–527 (2017).

Luc Gaudreau

Dubois, J.-C. et al. A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination. Nucleic Acids Res. (2017).

Laflamme, L., Guillemette, B. & Gaudreau, L. An Assay for Measuring Histone Variant Exchange within Nucleosomes In Vitro. Histones: Methods and Protocols 19–37 (2017).

Schmitt, C. et al. Patterns of diversity and spatial variability of β-defensin innate immune genes in a declining wild population of tree swallows. J. Hered. (2017).

Louis Gendron

Abdallah, K. & Gendron, L. The Delta Opioid Receptor in Pain Control. Handb Exp Pharmacol (2017).

Pirisedigh, A. et al. Synthesis and Evaluation of a (64)Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent. Org. Lett. 19, 2018–2021 (2017).

St-Louis, É. et al. Involvement of the coatomer protein complex I in the intracellular traffic of the delta opioid receptor. Mol. Cell. Neurosci. 79, 53–63 (2017).

Fernand Gobeil

Regoli, D. & Gobeil, F. Kallikrein-kinin system as the dominant mechanism to counteract hyperactive renin-angiotensin system. Can. J. Physiol. Pharmacol. 1–8 (2017).

Michel Grandbois

Besserer-Offroy, É. et al. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur. J. Pharmacol. 805, 1–13 (2017).

Brigitte Guérin

Blondin, D. P. et al. Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans. Cell Metab. (2017).

Blondin, D. P. et al. Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men. Nat Commun 8, 14146 (2017).

Mansour, N. et al. Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [(64) Cu]Cu/NOTA peptide-based gastrin-releasing peptide receptors antagonists. J Labelled Comp Radiopharm 60, 200–212 (2017).

Panet, F. et al. PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression. Eur. J. Cell Biol. (2017).

Pirisedigh, A. et al. Synthesis and Evaluation of a (64)Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent. Org. Lett. 19, 2018–2021 (2017).

Selivanova, S. V. et al. Clinical Trial with Sodium (99m)Tc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function. J. Nucl. Med. 58, 791–798 (2017).

Daniel Lafontaine

Chauvier, A. et al. Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation. Nat Commun 8, 13892 (2017).

Pierre Lavigne

Bédard, M., Maltais, L., Montagne, M. & Lavigne, P. Miz-1 and Max compete to engage c-Myc: implication for the mechanism of inhibition of c-Myc transcriptional activity by Miz-1. Proteins 85, 199–206 (2017).

Bédard, M., Roy, V., Montagne, M. & Lavigne, P. Structural Insights into c-Myc-interacting Zinc Finger Protein-1 (Miz-1) Delineate Domains Required for DNA Scanning and Sequence-specific Binding. J. Biol. Chem. 292, 3323–3340 (2017).

Maltais, L. et al. Biophysical characterization of the b-HLH-LZ of ΔMax, an alternatively spliced isoform of Max found in tumor cells: Towards the validation of a tumor suppressor role for the Max homodimers. PLoS ONE 12, e0174413 (2017).

Christine Lavoie

Duclos, C., Lavoie, C. & Denault, J.-B. Caspases rule the intracellular trafficking cartel. FEBS J. 284, 1394–1420 (2017).

Duclos, C. M. et al. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov 3, 16100 (2017).

Duclos, C. M. et al. Caspases play in traffic. Cell Death Dis 8, e2636 (2017).

Serrano, D. et al. GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Front Immunol 8, 94 (2017).

St-Louis, É. et al. Involvement of the coatomer protein complex I in the intracellular traffic of the delta opioid receptor. Mol. Cell. Neurosci. 79, 53–63 (2017).

Roger Lecomte

Caron, A. et al. Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue. Biochimie (2017).

Loignon-Houle, F., Bergeron, M., Pepin, C. M., Charlebois, S. A. & Lecomte, R. Simulation of scintillation light output in LYSO scintillators through a full factorial design. Phys Med Biol 62, 669–683 (2017).

Mansour, N. et al. Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [(64) Cu]Cu/NOTA peptide-based gastrin-releasing peptide receptors antagonists. J Labelled Comp Radiopharm 60, 200–212 (2017).

O’Farrell, A. C. et al. A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate. PLoS ONE 12, (2017).

Selivanova, S. V. et al. Clinical Trial with Sodium (99m)Tc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function. J. Nucl. Med. 58, 791–798 (2017).

Richard Leduc

Besserer-Offroy, É. et al. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur. J. Pharmacol. 805, 1–13 (2017).

Lahey, K. A. et al. Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS ONE 12, e0180259 (2017).

Murza, A. et al. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org. Biomol. Chem. 15, 449–458 (2017).

Perreault, S. et al. Older adults with heart failure treated with carvedilol, bisoprolol, or metoprolol tartrate: risk of mortality. Pharmacoepidemiol Drug Saf 26, 81–90 (2017).

Pirisedigh, A. et al. Synthesis and Evaluation of a (64)Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent. Org. Lett. 19, 2018–2021 (2017).

Wilkinson, D. J. et al. Matriptase induces metalloproteinase-dependent aggrecanolysis in vitro and in vivo: multiple mechanisms promote cartilage damage in osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.) (2017).

Claude Legault

Basdevant, B., Guilbault, A.-A., Beaulieu, S., Lauriers, A. J.-D. & Legault, C. Y. Iodine(III)-mediated synthesis of chiral α-substituted ketones: Recent advances and mechanistic insights. Pure and Applied Chemistry 89, 781–789 (2017).

Cocaud, C. et al. Tunable Approach for the Stereoselective Synthesis of 1-C-Diethylphosphono(difluoromethyl) Iminosugars as Glycosyl Phosphate Mimics. J. Org. Chem. 82, 2753–2763 (2017).

Dagenais, R., Lauriers, A. J.-D. & Legault, C. Y. Iodine(III)-Mediated Oxidative Hydrolysis of Haloalkenes: Investigation of the Effect of Iodine(III) Reagents. Synthesis (Germany) 49, 2928–2932 (2017).

Martin Lepage

Paré, G. et al. Emerging applications of intra-vital smart micro-imaging: from bench-to-bedside. in Microscopy and imaging science: practical approaches to applied research and education. (ed. Méndez-Vilas, A.) 120–133 (Formatex Research Center, 2017).

Olivier Lesur

Chagnon, F. et al. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit. Care Med. 45, e391–e398 (2017).

Murza, A. et al. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org. Biomol. Chem. 15, 449–458 (2017).

Paré, G. et al. Emerging applications of intra-vital smart micro-imaging: from bench-to-bedside. in Microscopy and imaging science: practical approaches to applied research and education. (ed. Méndez-Vilas, A.) 120–133 (Formatex Research Center, 2017).

Perez, J. R. et al. Tracking of Mesenchymal Stem Cells with Fluorescence Endomicroscopy Imaging in Radiotherapy-Induced Lung Injury. Sci Rep 7, 40748 (2017).

Jeffrey Leyton

Osati, S. et al. BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities. Bioorg. Med. Chem. Lett. 27, 443–446 (2017).

Éric Marsault

Besserer-Offroy, É. et al. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur. J. Pharmacol. 805, 1–13 (2017).

Chagnon, F. et al. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit. Care Med. 45, e391–e398 (2017).

Murza, A. et al. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org. Biomol. Chem. 15, 449–458 (2017).

Paré, G. et al. Emerging applications of intra-vital smart micro-imaging: from bench-to-bedside. in Microscopy and imaging science: practical approaches to applied research and education. (ed. Méndez-Vilas, A.) 120–133 (Formatex Research Center, 2017).

Rafaël Najmanovich

Chartier, M., Morency, L.-P., Zylber, M. I. & Najmanovich, R. J. Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects. BMC Pharmacol Toxicol 18, 18 (2017).

Chénard, T. et al. Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes. BMC Syst Biol 11, 60 (2017).

Frappier, V., Chartier, M. & Najmanovich, R. Applications of Normal Mode Analysis Methods in Computational Protein Design. Methods Mol. Biol. 1529, 203–214 (2017).

Jean-Luc Parent

Lucien, F. et al. Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance. Nat Commun 8, 15884 (2017).

St-Louis, É. et al. Involvement of the coatomer protein complex I in the intracellular traffic of the delta opioid receptor. Mol. Cell. Neurosci. 79, 53–63 (2017).

White, C. A. et al. β-Trace Protein Assays: A Comparison Between Nephelometric and ELISA Methodologies. Am. J. Kidney Dis. 69, 866–868 (2017).

Xavier Roucou

Delcourt, V. et al. Combined Mass Spectrometry Imaging and Top-down Microproteomics Reveals Evidence of a Hidden Proteome in Ovarian Cancer. EBioMedicine (2017).

Delcourt, V., Staskevicius, A., Salzet, M., Fournier, I. & Roucou, X. Small proteins encoded by unannotated ORFs are rising stars of the proteome, confirming shortcomings in genome annotations and current vision of an mRNA. Proteomics (2017).

Philippe Sarret

Besserer-Offroy, É. et al. The signaling signature of the neurotensin type 1 receptor with endogenous ligands. Eur. J. Pharmacol. 805, 1–13 (2017).

Chagnon, F. et al. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit. Care Med. 45, e391–e398 (2017).

Fanelli, R. et al. Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues. J. Med. Chem. 60, 3303–3313 (2017).

Murza, A. et al. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org. Biomol. Chem. 15, 449–458 (2017).

Patrick Vermette

Dubiel, E. A., Martin, B., Vigier, S. & Vermette, P. Real-time label-free detection and kinetic analysis of Etanercept—Protein A interactions using quartz crystal microbalance. Colloids and Surfaces B: Biointerfaces 149, 312–321 (2017).

Sharp, J. & Vermette, P. An In-situ glucose-stimulated insulin secretion assay under perfusion bioreactor conditions. Biotechnology Progress 33, 454–462 (2017).

Vigier, S. et al. Composition and organization of the pancreatic extracellular matrix by combined methods of immunohistochemistry, proteomics and scanning electron microscopy. Current Research in Translational Medicine 65, 31–39 (2017).