Publications 2015

M’Hamed Bentourkia

Determination of the Input Function at the Entry of the Tissue of Interest and Its Impact on PET Kinetic Modeling Parameters
Bentourkia, M.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 17, no 6 (2015): 748 56.

A real-time follow-up of photodynamic therapy during PET imaging
Boubacar, P., O.Sarrhini, R. Lecomte, J. E. van Lier, et M. Bentourkia.
Photodiagnosis and Photodynamic Therapy 12, no 3 (2015): 428 35.

Optimization of the reference region method for dual pharmacokinetic modeling using Gd-DTPA/MRI and (18) F-FDG/PET
Poulin, E., R. Lebel, E. Croteau, M. Blanchette, L. Tremblay, R. Lecomte, M. Bentourkia, et M. Lepage.
Magnetic resonance in medicine 73, no 2 (2015): 740 48.

André Cantin

Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions
Boulanger, S., G. Mitchell, K. Bouarab, E. Marsault, A. Cantin, E. H. Frost, E. Deziel, et F. Malouin.
Antimicrobial Agents and Chemotherapy 59, no 12 (2015): 7458 64.

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy
Cantin, A. M.
, D. Hartl, M. W. Konstan, et J. F. Chmiel.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 14, no 4 (2015): 419 30.

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium
Freschi, L., J. Jeukens, I. Kukavica-Ibrulj, B. Boyle, M.-J. Dupont, J. Laroche, S. Larose, H. Maaroufi, JL. Fothergill , M. Moore , GL Winsor , SD Aaron, J Barbeau , SC Bell , JL Burns , M Camara, A.M. Cantin  et al.
Frontiers in Microbiology 6 (2015).

Proresolving Action of Docosahexaenoic Acid Monoglyceride in Lung Inflammatory Models Related to Cystic Fibrosis
Morin, C., A. M. Cantin, E. Rousseau, M. Sirois, C. Sirois, E. Rizcallah, et S. Fortin.
American journal of respiratory cell and molecular biology 53, no 4 (2015): 574 83.

Considerations for the Conduct of Clinical Trials with Antiinflammatory Agents in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report
Torphy, T. J., J. Allen, A. M. Cantin, M. W. Konstan, F. J. Accurso, E. Joseloff, F. A. Ratjen, J. F. Chmiel, et Antiinflammatory Therapy Working Group.
Annals of the American Thoracic Society 12, no 9 (2015): 1398 1406.

The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection
Traboulsi, H., A. Cloutier, K. Boyapelly, M. A. Bonin, E. Marsault, A. M. Cantin, et M. V. Richter.
Antimicrobial Agents and Chemotherapy 59, no 10 (2015): 6317 27.

Paul Charette

Improved resolution in SPR and MCWG microscopy by combining images acquired with distinct mode propagation directions
Banville, F. A., T. Söllradl, P.-J. Zermatten, M.Grandbois, et P. G. Charette.
Optics letters 40, no 7 (2015): 1165–1168.

Implementation Study of Single Photon Avalanche Diodes (SPAD) in HV CMOS Technology
Bérubé, B.-L., V.-P. Rhéaume, S. Parent, L. Maurais, A. Corbeil Therrien,P. G. Charette, S. A. Charlebois, R. Fontaine, et J.-F. Pratte.
IEEE Transactions on Nuclear Science 62, no 3 (2015): 710–718.

Surface Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells
Bourassa, P., T. Söllradl, J.-S. Maltais, P. G. Charette, L. Gendron, et M. Grandbois.
Label-Free Biosensor Methods in Drug Discovery, 2015, 183–195.

Enhancements to surface plasmon resonance imaging for biosensing
Charette, P. G.
In Photonics North, 2015, 1–1. IEEE, 2015.

Buried Quad Junction Photodetector Signal Processing for Multi-Label Fluorescence Detection
Courcier, T., P. Pittet, L. Quiquerez, P. G. Charette, V. Aimez, et G.-N. Lu.
Sensor Letters 13, no 5 (2015): 430–434.

Hybrid metallic ion-exchanged waveguides for SPR biological sensing
de Bonnault, S., D. Bucci, P. J. Zermatten,P. G. Charette, et J. E. Broquin.
In SPIE OPTO, 93650D–93650D. International Society for Optics and Photonics, 2015.

Plasmonic Imaging Systems and Dedicated Functionalized Biochips for Biosensing
de la Chapelle, M., Lamy, P. G. Gucciardi, N. Lidgi-Guigui, J. Moreau, J.-P. Cloarec, P. G. Charette, G. Barbillon, et M. Canvaa.
In Handbook of Enhanced Spectroscopy, 35–100. Pan Stanford, 2015.

A CMOS Buried Quad pn Junction Photodetector Model
Feruglio, S., T. Courcier, O. Tsiakaka, A. Karami, A. Alexandre-Gauthier, O. Romain, V. Aimez, P. G. Charette, P. Pittet, et G.-N. Lu.
IEEE Sensors Journal 16, no 6 (2015): 1611–1620.

CMOS buried multi-junction (BMJ) detector for bio-chemical analysis
Lu, G.-N., T. Courcier, B. Mamdy, S. Feruglio, P. G. Charette, V. Aimez, O. Romain, et P. Pittet.
In Applied Optics and Photonics China (AOPC2015), 967412–967412. International Society for Optics and Photonics, 2015.

Visualization and quantification of cell monolayer integrity and single cell activity using metal clad waveguide imaging based on a high numerical aperture microscope objective
Sollradl, T., F. A. Banville, U. Frohlich, V. Chabot, M. Grandbois, et P. G. Charette.
In Photonics North, 2015, 1–1. IEEE, 2015.

Robert Day

Therapeutic uses of furin and its inhibitors: a patent review
Couture, F., A. Kwiatkowska, Y. L. Dory, et R. Day.
Expert opinion on therapeutic patents 25, no 4 (2015): 379 96.

Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity
Couture, F., K. Ly, C. Levesque, A. Kwiatkowska, S. Ait-Mohand, R. Desjardins, B. Guerin, et R. Day.
BioMed research international 2015, no Journal Article (2015): 824014.

Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study
Duhamel, M., F. Rodet, N. Delhem, F. Vanden Abeele, F. Kobeissy, S. Nataf, L. Pays, R. Desjardins, H. Gagnon, M. Wisztorski, I. Fournier, R. Day, M. Salzet
Molecular & cellular proteomics : MCP 14, no 11 (2015): 2857 77.

The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2)
Kara, I., M. Poggi, B. Bonardo, R. Govers, J. F. Landrier, S. Tian, I. Leibiger, R. Day, J. W. Creemers, et F. Peiretti.
The Journal of biological chemistry 290, no 5 (2015): 2812 21.

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System
Le Coupanec, A., M. Desforges, M. Meessen-Pinard, M. Dube, R. Day, N. G. Seidah, et P. J. Talbot.
PLoS pathogens 11, no 11 (2015): e1005261.

PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation
Levesque, C., F. Couture, A. Kwiatkowska, R. Desjardins, B. Guerin, W. A. Neugebauer, et R. Day.
Oncotarget 6, no 6 (2015): 3680 93.

Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase
Semaan, W., L. Desbiens, M. Houde, J. Labonte, H. Gagnon, D. Yamamoto, S. Takai, T. Laidlaw, G. Bkaily, A. Schwertani, G. Pejler, C. Levesque, R. Desjardins, R. Day, P. D'Orleans-Juste
Biochemical pharmacology 94, no 2 (2015): 91 100.

Artur de Brum Fernandes

Depressive symptoms predict future simple disease activity index scores and simple disease activity index remission in a prospective cohort of patients with early inflammatory polyarthritis
Leblanc-Trudeau, C., P. L. Dobkin, N. Carrier, P. Cossette, A. J. de Brum-Fernandes, P. Liang, A. Masetto, et G. Boire.
Rheumatology (Oxford, England) 54, no 12 (2015): 2205 14.

Pedro d’Orléans-Juste

Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells
Bkaily, G., L. Avedanian, J. Al-Khoury, M. Chamoun, R. Semaan, C. Jubinville-Leblanc, P. D’Orleans-Juste, et D. Jacques.
Canadian journal of physiology and pharmacology 93, no 4 (2015): 291 97.

Using carboxyfluorescein diacetate succinimidyl ester to monitor intracellular protein glycation
Boucher, J., E. Simard, U. Froehlich, P. D’Orleans-Juste, et M. Grandbois.
Analytical Biochemistry 478, no Journal Article (2015): 73 81.

Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase
Semaan, W., L. Desbiens, M. Houde, J. Labonte, H. Gagnon, D. Yamamoto, S. Takai, T. Laidlaw, G. Bkaily, A. Schwertani, G. Pejler, C. Levesque, R. Desjardins, R. Day, P. D'Orleans-Juste
Biochemical pharmacology 94, no 2 (2015): 91 100.

Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function
Simard, E., T. Sollradl, J. S. Maltais, J. Boucher, P. D’Orleans-Juste, et M. Grandbois.
PloS one 10, no 8 (2015): e0128881.

Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment
Simplicio, J. A., L. B. Resstel, D. P. Tirapelli, P. D’Orleans-Juste, et C. R. Tirapelli.
Vascular pharmacology 73, no Journal Article (2015): 124 37. d

Yves Dory

Therapeutic uses of furin and its inhibitors: a patent review
Couture, F., A. Kwiatkowska, Y. L. Dory, et R. Day.
Expert opinion on therapeutic patents 25, no 4 (2015): 379 96.

A new comonomer design for enhancing the pH-triggered LCST shift of thermosensitive polymers
Zhang, H., T. Marmin, É. Cuierrier, A. Soldera, Y.L. Dory, et Y. Zhao.
Polymer Chemistry 6, no 37 (2015): 6644–6650.

Emanuel Escher

Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the beta-Arrestin Pathway Using Molecular Dynamics Simulations
Cabana, J., B. Holleran, R. Leduc, E. Escher, G. Guillemette, et P. Lavigne.
The Journal of biological chemistry 290, no 25 (2015): 15835 54.

Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity
Domazet, I., B. J. Holleran, A. Richard, C. Vandenberghe, P. Lavigne, E. Escher, R. Leduc, et G. Guillemette.
Molecular pharmacology 87, no 6 (2015): 982 95.

David Fortin

3D interactive tractography-informed resting-state fMRI connectivity
Chamberland, M., M. Bernier, D. Fortin, K. Whittingstall, et M. Descoteaux.
Frontiers in neuroscience 9, no Journal Article (2015): 275.

Cyclooxygenase-2 inhibitor prevents radiation-enhanced infiltration of F98 glioma cells in brain of Fischer rat
Desmarais, G., G. Charest,D. Fortin, R. Bujold, D. Mathieu, et B. Paquette.
International journal of radiation biology 91, no 8 (2015): 624 33.

Chemotherapy Delivery Strategies to the Central Nervous System: neither Optional nor Superfluous
Drapeau, A., et D. Fortin.
Current cancer drug targets 15, no 9 (2015): 752 68.

Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta
Roy, L. O., M. B. Poirier, et D. Fortin.
Investigational new drugs 33, no 5 (2015): 1020 31.

Transforming growth factor-beta and its implication in the malignancy of gliomas
Roy, L.O., M.B. Poirier, et D. Fortin
Targeted oncology 10, no 1 (2015): 1 14.

Convection-enhancement delivery of platinum-based drugs and Lipoplatin(TM) to optimize the concomitant effect with radiotherapy in F98 glioma rat model
Shi, M., D. Fortin, L. Sanche, et B. Paquette.
Investigational new drugs 33, no 3 (2015): 555 63.

Seeing More by Showing Less: Orientation-Dependent Transparency Rendering for Fiber Tractography Visualization
Tax, C. M., M. Chamberland, M. van Stralen, M. A. Viergever, K. Whittingstall, D. Fortin, M. Descoteaux, et A. Leemans.
PloS one 10, no 10 (2015): e0139434.

Luc Gaudreau

Detection of Short-Range DNA Interactions in Mammalian Cells Using High-Resolution Circular Chromosome Conformation Capture Coupled to Deep Sequencing
Millau, J. F., etL. Gaudreau.
Methods in molecular biology (Clifton, N.J.) 1334, no Journal Article (2015): 245 59.

Louis Gendron

Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain
Beaudry, H.,L. Gendron, et J. A. Morón.
European Journal of Neuroscience 41, no 7 (2015): 901–907.

Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5
Beaudry, H., A.-A. Mercier-Blais, C. Delaygue,C. Lavoie, J.-L. Parent, W. Neugebauer, et L. Gendron.
British journal of pharmacology 172, no 10 (2015): 2573–2587.

Surface Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells
Bourassa, P., T. Söllradl, J.-S. Maltais, P. G. Charette, L. Gendron, et M. Grandbois.
Label-Free Biosensor Methods in Drug Discovery, 2015, 183–195.

Recent advances on the delta opioid receptor: from trafficking to function
Gendron, L
., N. Mittal, H. Beaudry, et W. Walwyn.
British journal of pharmacology 172, no 2 (2015): 403 19.

Fernand Gobeil

High Resolution Imaging and Function of Nuclear G Protein-Coupled Receptors (GPCRs)
Bhosle, V. K., F. Gobeil, J. C. Rivera, A. Ribeiro-da-Silva, et S. Chemtob.
Methods in Molecular Biology (Clifton, N.J.) 1234 (2015): 81 97. doi:10.1007/978-1-4939-1755-6_8.

Kinin Receptor Agonism Restores Hindlimb Postischemic Neovascularization Capacity in Diabetic Mice
Desposito, D., L. Potier, C. Chollet, F. Gobeil, R. Roussel, F. Alhenc-Gelas, N. Bouby, et L. Waeckel.
The Journal of Pharmacology and Experimental Therapeutics 352, no 2 (février 2015): 218 26. doi:10.1124/jpet.114.219196.

Critical Insights into the Beneficial and Protective Actions of the Kallikrein-Kinin System
Regoli, D., et F. Gobeil.
Vascular Pharmacology 64 (janvier 2015): 1 10. doi:10.1016/j.vph.2014.12.003.

Michel Grandbois

Improved resolution in SPR and MCWG microscopy by combining images acquired with distinct mode propagation directions
Banville, F. A., T. Söllradl, P.-J. Zermatten, M.Grandbois, et P. G. Charette.
Optics letters 40, no 7 (2015): 1165–1168.

Using carboxyfluorescein diacetate succinimidyl ester to monitor intracellular protein glycation
Boucher, J., E. Simard, U. Froehlich, P. D’Orleans-Juste, et M. Grandbois.
Analytical Biochemistry 478, no Journal Article (2015): 73 81.

Surface Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells
Bourassa, P., T. Söllradl, J.-S. Maltais, P. G. Charette, L. Gendron, et M. Grandbois.
Label-Free Biosensor Methods in Drug Discovery, 2015, 183–195.

Increased Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity
Lacraz, G., A. J. Rouleau, V. Couture, T. Sollrald, G. Drouin, N. Veillette, M. Grandbois, et G. Grenier.
PloS one 10, no 8 (2015): e0136217.

Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function
Simard, E., T. Sollradl, J. S. Maltais, J. Boucher, P. D’Orleans-Juste, et M. Grandbois.
PloS one 10, no 8 (2015): e0128881.

Visualization and quantification of cell monolayer integrity and single cell activity using metal clad waveguide imaging based on a high numerical aperture microscope objective
Sollradl, T., F. A. Banville, U. Frohlich, V. Chabot, M. Grandbois, et P. G. Charette.
In Photonics North, 2015, 1–1. IEEE, 2015.

Increased microenvironment stiffness in damaged myofibers promotes myogenic progenitor cell proliferation
Trensz, F., F. Lucien, V. Couture, T. Sollrald, G. Drouin, A. J. Rouleau, M. Grandbois, G. Lacraz, et G. Grenier.
Skeletal muscle 5, no Journal Article (2015): 5 015 0030 1.

Brigitte Guérin

Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men
Blondin, D. P., S. M. Labbe, S. Phoenix, B. Guerin, E. E. Turcotte, D. Richard, A. C. Carpentier, et F. Haman.
The Journal of physiology 593, no 3 (2015): 701 14.

Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes
Blondin, D. P., S. M. Labbé, C. Noll, M. Kunach, S. Phoenix, B. Guerin, É. E. Turcotte, F. Haman, D. Richard, et A. C. Carpentier.
Diabetes 64, no 7 (2015): 2388 97. doi:10.2337/db14-1651.

Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity
Couture, F., K. Ly, C. Levesque, A. Kwiatkowska, S. Ait-Mohand, R. Desjardins, B. Guerin, et R. Day.
BioMed research international 2015, no Journal Article (2015): 824014.

Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans
Kunach, M., C. Noll, S. Phoenix, B. Guerin, J. P. Baillargeon, E. E. Turcotte, et A. C. Carpentier.
Diabetes 64, no 7 (2015): 2432 41.

PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation
Levesque, C., F. Couture, A. Kwiatkowska, R. Desjardins, B. Guerin, W. A. Neugebauer, et R. Day.
Oncotarget 6, no 6 (2015): 3680 93.

Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects
Noll, C., M. Kunach, F. Frisch, L. Bouffard, S. Dubreuil, F. Jean-Denis, S. Phoenix, S. C. Cunnane, B. Guerin, E. E. Turcotte et A. C. Carpentier.
Diabetes 64, no 11 (2015): 3690 99. doi:10.2337/db15-0337.

Phase I Clinical Trial Using Sodium Pertechnetate 99mTc Produced by Medium-Energy Cyclotron
Selivanova, S., É. Lavallée, H. Senta, L. Caouette, A. Zyuzin, A. McEwan, J. van Lier, B. Guerin,R. Lecomte, et É.Turcotte.
Journal of Nuclear Medicine 56, no supplement 3 (2015): 475 475.

Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications
Selivanova, S. V., É. Lavallée, H. Senta, L. Caouette, J. A. Sader, E. J. van Lier, A. Zyuzin, J. E. van Lier, B. Guérin, É. Turcotte et R. Lecomte
Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine 56, no 10 (2015): 1600 1608.

Gaetan Guillemette

Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the beta-Arrestin Pathway Using Molecular Dynamics Simulations
Cabana, J., B. Holleran, R. Leduc, E. Escher, G. Guillemette, et P. Lavigne.
The Journal of biological chemistry 290, no 25 (2015): 15835 54.

Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity
Domazet, I., B. J. Holleran, A. Richard, C. Vandenberghe, P. Lavigne, E. Escher, R. Leduc, et G. Guillemette.
Molecular pharmacology 87, no 6 (2015): 982 95.

Daniel Lafontaine

Functional Studies of DNA-Protein Interactions Using FRET Techniques
Blouin, S., T. D. Craggs, D. A. Lafontaine, et J. C. Penedo.
Methods in molecular biology (Clifton, N.J.) 1334, no Journal Article (2015): 115 41. doi:10.1007/978-1-4939-2877-4_8.

Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile
Bordeleau, E., E. B. Purcell, D. A. Lafontaine, L. C. Fortier, R. Tamayo, et V. Burrus.
Journal of Bacteriology 197, no 5 (2015): 819 32. doi:10.1128/JB.02340-14.

Probing of Nascent Riboswitch Transcripts
Chauvier, A., et D. A. Lafontaine.
Methods in molecular biology (Clifton, N.J.) 1334, no Journal Article (2015): 109 14. doi:10.1007/978-1-4939-2877-4_7.

A kissing loop is important for btuB riboswitch ligand sensing and regulatory control
Lussier, A., L. Bastet, A. Chauvier, et D. A. Lafontaine.
The Journal of biological chemistry 290, no 44 (2015): 26739 51. doi:10.1074/jbc.M115.684134.

Role of lysine binding residues in the global folding of the lysC riboswitch
Smith-Peter, E., A. M. Lamontagne, et D. A. Lafontaine.
RNA biology 12, no 12 (2015): 1372 82. doi:10.1080/15476286.2015.1094603.

Pierre Lavigne

Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the beta-Arrestin Pathway Using Molecular Dynamics Simulations
Cabana, J., B. Holleran, R. Leduc, E. Escher, G. Guillemette, et P. Lavigne.
The Journal of biological chemistry 290, no 25 (2015): 15835 54.

Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity
Domazet, I., B. J. Holleran, A. Richard, C. Vandenberghe, P. Lavigne, E. Escher, R. Leduc, et G. Guillemette.
Molecular pharmacology 87, no 6 (2015): 982 95.

The binding site specificity of STARD4 subfamily: Breaking the cholesterol paradigm
Letourneau, D., A. Lefebvre, P. Lavigne, et J. G. LeHoux.
Molecular and cellular endocrinology 408, no Journal Article (2015): 53 61.

GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival
Li, X., P. Lavigne, et C. Lavoie.
Molecular biology of the cell 26, no 24 (2015): 4412 26.

Christine Lavoie

Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5
Beaudry, H., A.-A. Mercier-Blais, C. Delaygue, C. Lavoie, J.-L. Parent, W. Neugebauer, et L. Gendron.
British journal of pharmacology 172, no 10 (2015): 2573–2587.

GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival
Li, X., P. Lavigne, et C. Lavoie.
Molecular biology of the cell 26, no 24 (2015): 4412 26.

Macrocyclic cell penetrating peptides: a study of structure-penetration properties
Traboulsi, H., H. Larkin, M. A. Bonin, L. Volkov, C. L. Lavoie, et E. Marsault.
Bioconjugate chemistry 26, no 3 (2015): 405 11.

Roger Lecomte

Improved LabPET Detectors Using (LGSO) Scintillator Blocks
Bergeron, M., C. M. Pepin, J. Cadorette, F. Loignon-Houle, R. Fontaine, et R. Lecomte.
IEEE Transactions on Nuclear Science 62, no 1 (2015): 36 41.

LabPET II, an APD-based Detector Module with PET and Counting CT Imaging Capabilities
Bergeron, M., C. Thibaudeau, J. Cadorette, M. A. Tétrault, C. M. Pepin, J. Clerk-Lamalice, F. Loignon-Houle, M. Davies, H. Dautet, P. Deschamps, R. Fontaine et R. Lecomte
IEEE Transactions on Nuclear Science 62, no 3 (2015): 756 65.

A real-time follow-up of photodynamic therapy during PET imaging
Boubacar, P., O.Sarrhini, R. Lecomte, J. E. van Lier, et M. Bentourkia.
Photodiagnosis and Photodynamic Therapy 12, no 3 (2015): 428 35.

Automatic Channel Fault Detection and Diagnosis System for a Small Animal APD-Based Digital PET Scanner
Charest, J., J. F. Beaudoin, J. Cadorette, R. Lecomte, C. A. Brunet, et R. Fontaine.
IEEE Transactions on Nuclear Science 62, no 3 (2015): 1070 76.

Comparison of Semi-Automatic Cardiac Analysis Software for the Evaluation of the Left Ventricular Ejection Fraction in Small Animal PET
Croteau, E., O. Sarrhini, S. Gascon, J. Rousseau, R. Lecomte, et P.-M. Jodoin.
Journal of Nuclear Medicine 56, no supplement 3 (2015): 1792 1792.

Cardiac PET Imaging of Perfusion, Metabolism and Function in a Mouse Model of Cardiotoxicity Induced by Doxorubicin Chemotherapy
Gascon, S., E. Croteau, O. Sarrhini, S. Tremblay, M.-O. B. Biancamano, É. Turcotte, et R. Lecomte.
ournal of Nuclear Medicine 56, no supplement 3 (2015): 1475 1475.

Real Time Artificial Neural Network FPGA Implementation for Triple Coincidences Recovery in PET
Geoffroy, C., J.-B. Michaud, M.-A. Tetrault, J. Clerk-Lamalice, C.-A. Brunet, R. Lecomte, et R. Fontaine.
IEEE Transactions on Nuclear Science 62, no 3 (2015): 824 31.

(18)F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain
Guillot, M., G. Chartrand, R. Chav, J. Rousseau, J. F. Beaudoin, J. Martel-Pelletier, J. P. Pelletier, R. Lecomte, J. A. de Guise, et E. Troncy.
Veterinary journal (London, England : 1997) 204, no 3 (2015): 299 303.

In Vivo Measurement of Energy Substrate Contribution to Cold-Induced Brown Adipose Tissue Thermogenesis
Labbé, S. M., A. Caron, I. Bakan, M. Laplante, A. C. Carpentier, R. Lecomte, et D. Richard.
The FASEB Journal 29, no 5 (2015): 2046 58..

Metal Chelate Grafting at the Surface of Mesoporous Silica Nanoparticles (MSNs): Physico-Chemical and Biomedical Imaging Assessment
Laprise-Pelletier, M., M. Bouchoucha, J. Lagueux, P. Chevallier, R. Lecomte, Y. Gossuin, Fr. Kleitz, et M.-A. Fortin.
J. Mater. Chem. B 3, no 5 (2015): 748 58.

Sensitivity Increase Through a Neural Network Method for LOR Recovery of ICS Triple Coincidences in High-Resolution Pixelated- Detectors PET Scanners
Michaud, J. B., M. A. Tétrault, J. F. Beaudoin, J. Cadorette, J. D. Leroux, C. A. Brunet, R. Lecomte, et R. Fontaine.
IEEE Transactions on Nuclear Science 62, no 1 (2015): 82 94.

Postprandial fatty acid uptake and adipocyte remodeling in angiotensin type 2 receptor-deficient mice fed a high-fat/high-fructose diet
Noll, C., S. M. Labbe, S. Pinard, M. Shum, L. Bilodeau, L. Chouinard, S. Phoenix, R. Lecomte, A. C. Carpentier, et N. Gallo-Payet.
Adipocyte 5, no 1 (2015): 43 52.

Optimization of the reference region method for dual pharmacokinetic modeling using Gd-DTPA/MRI and (18) F-FDG/PET
Poulin, E., R. Lebel, E. Croteau, M. Blanchette, L. Tremblay, R. Lecomte, M. Bentourkia, et M. Lepage.
Magnetic resonance in medicine 73, no 2 (2015): 740 48.

Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism
Roussel, E., M.-C. Drolet, E. Walsh-Wilkinson, W. Dhahri, D. Lachance, S. Gascon, O. Sarrhini, J.A. Rousseau, R. Lecomte, J. Couet et M. Arsenault
BioMed Research International 2015 (2015): e949624.

Phase I Clinical Trial Using Sodium Pertechnetate 99mTc Produced by Medium-Energy Cyclotron
Selivanova, S., É. Lavallée, H. Senta, L. Caouette, A. Zyuzin, A. McEwan, J. van Lier, B. Guerin,R. Lecomte, et É.Turcotte.
Journal of Nuclear Medicine 56, no supplement 3 (2015): 475 475.

Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications
Selivanova, S. V., É. Lavallée, H. Senta, L. Caouette, J. A. Sader, E. J. van Lier, A. Zyuzin, J. E. van Lier, B. Guérin, É. Turcotte et R. Lecomte
Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine 56, no 10 (2015): 1600 1608.

Multipinhole SPECT helical scan parameters and imaging volume
Yao, R., X. Deng, Q. Wei, T. Dai, T. Ma, et R. Lecomte.
Medical physics 42, no 11 (2015): 6599 6609.

Richard Leduc

Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the beta-Arrestin Pathway Using Molecular Dynamics Simulations
Cabana, J., B. Holleran, R. Leduc, E. Escher, G. Guillemette, et P. Lavigne.
The Journal of biological chemistry 290, no 25 (2015): 15835 54.

Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity
Domazet, I., B. J. Holleran, A. Richard, C. Vandenberghe, P. Lavigne, E. Escher, R. Leduc, et G. Guillemette.
Molecular pharmacology 87, no 6 (2015): 982 95.

Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues
Fanelli, R., E. Besserer-Offroy, A. Rene, J. Cote, P. Tetreault, J. Collerette-Tremblay, J. M. Longpre, R. Leduc, J. Martinez, P. Sarret et F. Cavelier
Journal of medicinal chemistry 58, no 19 (2015): 7785 95.

Signaling Switch of the Urotensin II Vasosactive Peptide GPCR: Prototypic Chemotaxic Mechanism in Glioma
Lecointre, C., L. Desrues, J. E. Joubert, N. Perzo, P.-O. Guichet, V. Le Joncour, C. Brulé, M. Chabbert, R. Leduc, L. Prézeau, A. Laquerrière, F. Proust P. Gandolfo, F. Morin et H. Castel
Oncogene 34, no 39 (2015): 5080 94.

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action
Murza, A., E. Besserer-Offroy, J. Cote, P. Berube, J. M. Longpre, R. Dumaine, O. Lesur, M. Auger-Messier, R. Leduc, P. Sarret et E. Marsault
Journal of medicinal chemistry 58, no 5 (2015): 2431 40.

Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling
Zoratti, G. L., L. M. Tanabe, F. A. Varela, A. S. Murray, C. Bergum, E. Colombo, J. E. Lang, A. A. Molinolo, R. Leduc, E. Marsault, J. Boerner et K. List
Nature communications 6, no Journal Article (2015): 6776.

Claude Legault

Enantioselective Iodine(III)-Mediated Synthesis of alpha-Tosyloxy Ketones: Breaking the Selectivity Barrier
Basdevant, B., et C. Y. Legault.
Organic letters 17, no 19 (2015): 4918 21.

Study of the Reactivity of [Hydroxy(tosyloxy)iodo]benzene Toward Enol Esters to Access alpha-Tosyloxy Ketones
B. Basdevant et C. Y. Legault.
The Journal of organic chemistry 80, no 13 (2015): 6897 6902.

Mechanistic insights on the iodine(III)-mediated alpha-oxidation of ketones
Beaulieu, S., et C. Y. Legault.
Chemistry (Weinheim an der Bergstrasse, Germany) 21, no 31 (2015): 11206 11.

Revised mechanistic explanation for the alcohol-promoted amination of benzylic fluorides under highly concentrated conditions: Computational and experimental evidence on a model substrate
Champagne, P. A., M. Drouin, C. Y. Legault, C. Audubert, et J.-F. Paquin.
Journal of Fluorine Chemistry 171 (2015): 113–119.

Metathetical Redox Reaction of (Diacetoxyiodo)arenes and Iodoarenes
Jobin-Des Lauriers, A., et C. Y. Legault.
Molecules (Basel, Switzerland) 20, no 12 (2015): 22635 44.

Origin of chemoselectivity in N-heterocyclic carbene catalyzed cross-benzoin reactions: DFT and experimental insights
Langdon, S. M., C. Y. Legault, et M. Gravel.
The Journal of organic chemistry 80, no 7 (2015): 3597 3610. doi:10.1021/acs.joc.5b00301.

Copper-catalyzed O-arylation of N-protected 1, 2-aminoalcohols using functionalized trivalent organobismuth reagents
Petiot, P., J. Dansereau, M. Hébert, I. Khene, T. Ahmad, S. Samaali, M. Leroy, F. Pinsonneault, C. Y. Legault, et A. Gagnon.
Organic & biomolecular chemistry 13, no 5 (2015): 1322–1327.

Martin Lepage

Exposition to group B streptococcal maternal inflammation: White matter injury and autistic-like behavior predominantly affecting male rat offspring.
Bergeron, J., J. Deslauriers, S. Grignon, L. C. Fortier, M. Lepage, T. Stroh, C. Poyart, et G. Sébire.
International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience 47, no Pt A (2015): 47.

Smart imaging of acute lung injury: exploration of myeloperoxidase activity using in vivo endoscopic confocal fluorescence microscopy
Chagnon, F., A. Bourgouin, R. Lebel, M. A. Bonin, E. Marsault, M. Lepage, et O. Lesur.
American journal of physiology.Lung cellular and molecular physiology 309, no 6 (2015): L543-51.

Optimization of the reference region method for dual pharmacokinetic modeling using Gd-DTPA/MRI and (18) F-FDG/PET
Poulin, E., R. Lebel, E. Croteau, M. Blanchette, L. Tremblay, R. Lecomte, M. Bentourkia, et M. Lepage.
Magnetic resonance in medicine 73, no 2 (2015): 740 48.

Éric Marsault

Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions
Boulanger, S., G. Mitchell, K. Bouarab, E. Marsault, A. Cantin, E. H. Frost, E. Deziel, et F. Malouin.
Antimicrobial Agents and Chemotherapy 59, no 12 (2015): 7458 64.

Smart imaging of acute lung injury: exploration of myeloperoxidase activity using in vivo endoscopic confocal fluorescence microscopy
Chagnon, F., A. Bourgouin, R. Lebel, M. A. Bonin, E. Marsault, M. Lepage, et O. Lesur.
American journal of physiology.Lung cellular and molecular physiology 309, no 6 (2015): L543-51.

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action
Murza, A., E. Besserer-Offroy, J. Cote, P. Berube, J. M. Longpre, R. Dumaine, O. Lesur, M. Auger-Messier, R. Leduc, P. Sarret et E. Marsault
Journal of medicinal chemistry 58, no 5 (2015): 2431 40.

The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection
Traboulsi, H., A. Cloutier, K. Boyapelly, M. A. Bonin, E. Marsault, A. M. Cantin, et M. V. Richter.
Antimicrobial Agents and Chemotherapy 59, no 10 (2015): 6317 27.

Macrocyclic cell penetrating peptides: a study of structure-penetration properties
Traboulsi, H., H. Larkin, M. A. Bonin, L. Volkov, C. L. Lavoie, et E. Marsault.
Bioconjugate chemistry 26, no 3 (2015): 405 11.

Solid-Phase Parallel Synthesis of Functionalised Medium-to-Large Cyclic Peptidomimetics through Three-Component Coupling Driven by Aziridine Aldehyde Dimers
Treder, A. P., J. L. Hickey, M. C. Tremblay, S. Zaretsky, C. C. Scully, J. Mancuso, A. Doucet, A. K. Yudin, et E. Marsault.
Chemistry (Weinheim an der Bergstrasse, Germany) 21, no 25 (2015): 9249 55.

Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling
Zoratti, G. L., L. M. Tanabe, F. A. Varela, A. S. Murray, C. Bergum, E. Colombo, J. E. Lang, A. A. Molinolo, R. Leduc, E. Marsault, J. Boerner et K. List
Nature communications 6, no Journal Article (2015): 6776.

Rafael Najmanovich

Detection of Binding Site Molecular Interaction Field Similarities
Chartier, M., et R. J. Najmanovich.
Journal of chemical information and modeling 55, no 8 (2015): 1600 1615.

ENCoM server: exploring protein conformational space and the effect of mutations on protein function and stability
Frappier, V., M. Chartier, et R. J. Najmanovich.
Nucleic acids research 43, no W1 (2015): W395-400.

Vibrational entropy differences between mesophile and thermophile proteins and their use in protein engineering
Frappier, V., et R. J. Najmanovich.
Protein science : a publication of the Protein Society 24, no 4 (2015): 474 83.

NRGsuite: a PyMOL plugin to perform docking simulations in real time using FlexAID
Gaudreault, F., L. P. Morency, et R. J. Najmanovich.
Bioinformatics (Oxford, England) 31, no 23 (2015): 3856 58.

FlexAID: Revisiting Docking on Non-Native-Complex Structures
Gaudreault, F., et R. J. Najmanovich.
Journal of chemical information and modeling 55, no 7 (2015): 1323 36.

Achievements and challenges in structural bioinformatics and computational biophysics
Samish, I., P. E. Bourne, et R. J. Najmanovich.
Bioinformatics (Oxford, England) 31, no 1 (2015): 146 50.

Jean-Luc Parent

Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5
Beaudry, H., A.-A. Mercier-Blais, C. Delaygue,C. Lavoie, J.-L. Parent, W. Neugebauer, et L. Gendron.
British journal of pharmacology 172, no 10 (2015): 2573–2587.

Characterization of the Interaction Between the Prostaglandin D2 DP1 Receptor and the Intracellular L-Prostaglandin D Synthase
Binda, C., et J.-L. Parent.
In Nuclear G-Protein Coupled Receptors, édité par Bruce G. Allen et Terence E. Hébert, 53 67. Methods in Molecular Biology 1234. Springer New York, 2015.

Marek Rola Pleszczynski

Platelet-Activating Factor Induces Du-al-Specificity Phosphatase 1 and 5 Gene Expression
Lapointe, F., M. Stiffel, J.-P. Auger, M. Rola-Pleszczynski, et J. Stankova.
Pharmacology & Pharmacy 6, no 9 (2015): 442 50.

Enhanced Cysteinyl-Leukotriene Type 1 Receptor Expression in T Cells from House Dust Mite-Allergic Individuals Following Stimulation with Der P
Thivierge, M., S. Turcotte, M. Rola-Pleszczynski, et J. Stankova.
Journal of Immunology Research 2015 (2015): e384780.

Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and Migration
Wang, M., N. Mostafa El-Maghraby, S. Turcotte, M. Rola-Pleszczynski, et J. Stankova.
Mediators of inflammation 2015, no Journal Article (2015): 389849.

Philippe Sarret

Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1alpha (MODY3)-Deficient Mice
Brial, F., C. R. Lussier, K. Belleville, P. Sarret, et F. Boudreau.
Diabetes 64, no 9 (2015): 3314 20. doi:10.2337/db15-0124.

The Impact of Oxidative Stress on Dopaminergic Neurotransmission
Deslauriers, J., P. Sarret, et S. Grignon.
In Studies on Psychiatric Disorders, édité par Anna Dietrich-Muszalska, Ved Chauhan, et Sylvain Grignon, 197 210. Oxidative Stress in Applied Basic Research and Clinical Practice. Springer New York, 2015. doi:10.1007/978-1-4939-0440-2_10.

Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues
Fanelli, R., E. Besserer-Offroy, A. Rene, J. Cote, P. Tetreault, J. Collerette-Tremblay, J. M. Longpre, R. Leduc, J. Martinez, P. Sarret et F. Cavelier
Journal of medicinal chemistry 58, no 19 (2015): 7785 95.

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action
Murza, A., E. Besserer-Offroy, J. Cote, P. Berube, J. M. Longpre, R. Dumaine, O. Lesur, M. Auger-Messier, R. Leduc, P. Sarret et E. Marsault
Journal of medicinal chemistry 58, no 5 (2015): 2431 40.

Relationship between blood- and cerebrospinal fluid-bound neurotransmitter concentrations and conditioned pain modulation in pain-free and chronic pain subjects
Parent, A. J., N. Beaudet, K. Daigle, R. Sabbagh, Y. Sansoucy, S. Marchand,P. Sarret, et P. Goffaux.
The journal of pain : official journal of the American Pain Society 16, no 5 (2015): 436 44.

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2
Thomas, J. B., A. M. Giddings, S. Olepu, R. W. Wiethe, D. L. Harris, S. Narayanan, K. R. Warner, P. Sarret, J. M. Longpre, S. P. Runyon et B. P. Gilmour
Bioorganic & medicinal chemistry letters 25, no 2 (2015): 292 96.

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2
Thomas, J. B., A. M. Giddings, S. Olepu, R. W. Wiethe, K. R. Warner, P. Sarret, J. M. Longpre, S. P. Runyon, et B. P. Gilmour.
Bioorganic & medicinal chemistry letters 25, no 10 (2015): 2060 64.

Claude Spino

N-Heterocycles from Chromium Aminocarbenes
Déry, M., K. Assouvie, N. Heinrich, I. Rajotte, L.-P. D. Lefebvre, M.-A. Legault, et C. Spino.
Organic letters 17, no 5 (2015): 1312–1315.

Jana Stankova

Platelet-Activating Factor Induces Du-al-Specificity Phosphatase 1 and 5 Gene Expression
Lapointe, F., M. Stiffel, J.-P. Auger, M. Rola-Pleszczynski, et J. Stankova.
Pharmacology & Pharmacy 6, no 9 (2015): 442 50.

Enhanced Cysteinyl-Leukotriene Type 1 Receptor Expression in T Cells from House Dust Mite-Allergic Individuals Following Stimulation with Der P
Thivierge, M., S. Turcotte, M. Rola-Pleszczynski, et J. Stankova.
Journal of Immunology Research 2015 (2015): e384780.

Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and Migration
Wang, M., N. Mostafa El-Maghraby, S. Turcotte, M. Rola-Pleszczynski, et J. Stankova.
Mediators of inflammation 2015, no Journal Article (2015): 389849.

Yue Zhao

Orientation of Azobenzene Mesogens in Side-Chain Liquid Crystalline Polymers: Interplay between Effects of Mechanical Stretching, Photoisomerization and Thermal Annealing
Fu, S., et Y. Zhao.
Macromolecules 48, no 15 (2015): 5088–5098.

Gold nanoparticle-catalysed photosensitized water reduction for hydrogen generation
Li, D., J.-F. Wehrung, et Y. Zhao.
Journal of Materials Chemistry A 3, no 9 (2015): 5176–5182.

Therapeutic-Ultrasound-Triggered Shape Memory of a Melamine-Enhanced Poly(vinyl alcohol) Physical Hydrogel
Li, G., Q. Yan, H. Xia, et Y. Zhao.
ACS applied materials & interfaces 7, no 22 (2015): 12067 73. doi:10.1021/acsami.5b02234.

Poly (vinyl alcohol)–Poly (ethylene glycol) Double-Network Hydrogel: A General Approach to Shape Memory and Self-Healing Functionalities
Li, G., H. Zhang, D. Fortin, H. Xia, et Y. Zhao.
Langmuir 31, no 42 (2015): 11709–11716.

Anisotropic optical properties of oriented silver nanorice and nanocarrots in stretched polymer films
Tong, X., H. Liang, Y. Liu, L. Tan, D. Ma, et Y. Zhao.
Nanoscale 7, no 19 (2015): 8858 63.

Microfluidic Synthesis of Photoresponsive Spool-Like Block Copolymer Nanoparticles: Flow-Directed Formation and Light-Triggered Dissociation
Xu, Z., B. Yan, J. Riordon, Y. Zhao, D. Sinton, et M. G. Moffitt.
Chemistry of Materials 27, no 23 (2015): 8094–8104.

ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies
Yan, Q., et Y. Zhao.
Chemical Science 6, no 7 (2015): 4343–4349.

A new comonomer design for enhancing the pH-triggered LCST shift of thermosensitive polymers
Zhang, H., T. Marmin, É. Cuierrier, A. Soldera, Y.L. Dory, et Y. Zhao.
Polymer Chemistry 6, no 37 (2015): 6644–6650.