Publications 2015

M’Hamed Bentourkia

Bentourkia, M. Determination of the Input Function at the Entry of the Tissue of Interest and Its Impact on PET Kinetic Modeling Parameters. Mol Imaging Biol 17, 748–756 (2015).

Boubacar, P., Sarrhini, O., Lecomte, R., van Lier, J. E. & Bentourkia, M. »hamed. A real-time follow-up of photodynamic therapy during PET imaging. Photodiagnosis Photodyn Ther 12, 428–435 (2015).

Poulin, É. et al. Optimization of the reference region method for dual pharmacokinetic modeling using Gd-DTPA/MRI and (18) F-FDG/PET. Magn Reson Med 73, 740–748 (2015).

André Cantin

Boulanger, S. et al. Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions. Antimicrob. Agents Chemother. 59, 7458–7464 (2015).

Cantin, A. M., Hartl, D., Konstan, M. W. & Chmiel, J. F. Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy. J. Cyst. Fibros. 14, 419–430 (2015).

Freschi, L. et al. Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Front Microbiol 6, 1036 (2015).

Morin, C. et al. Proresolving Action of Docosahexaenoic Acid Monoglyceride in Lung Inflammatory Models Related to Cystic Fibrosis. Am. J. Respir. Cell Mol. Biol. 53, 574–583 (2015).

Torphy, T. J. et al. Considerations for the Conduct of Clinical Trials with Antiinflammatory Agents in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report. Ann Am Thorac Soc 12, 1398–1406 (2015).

Traboulsi, H. et al. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrob. Agents Chemother. 59, 6317–6327 (2015).

Paul Charette

Banville, F. A., Söllradl, T., Zermatten, P.-J., Grandbois, M. & Charette, P. G. Improved resolution in SPR and MCWG microscopy by combining images acquired with distinct mode propagation directions. Opt Lett 40, 1165–1168 (2015).

Berube, B.-L. et al. Implementation Study of Single Photon Avalanche Diodes (SPAD) in 0.8 m HV CMOS Technology. IEEE Transactions on Nuclear Science 62, 710–18 (2015).

Bourassa, P. et al. Surgace Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells. in Label-Free Biosensor Methods in Drug Discovery (ed. Fang, Y.) 183–195 (Springer New York, 2015).

Courcier, T. et al. Buried Quad Junction Photodetector Signal Processing for Multi-Label Fluorescence Detection. Sensor Letters 13, 430–434 (2015).

Fekecs, A. et al. Critical process temperatures for resistive InGaAsP/InP heterostructures heavily implanted by Fe or Ga ions. Nuclear Instruments and Methods in Physics Research, Section B (Beam Interactions with Materials and Atoms) 359, 99–106 (2015).

Moreau, J., Cloarec, J.-P., Charette, P., Barbillon, G. & Canvaa, M. Plasmonic Imaging Systems and Dedicated Functionalized Biochips for Biosensing in Handbook of Enhanced Spectroscopy 35–100 (Pan Stanford, 2015).

Robert Day

Couture, F., Kwiatkowska, A., Dory, Y. L. & Day, R. Therapeutic uses of furin and its inhibitors: a patent review. Expert Opin Ther Pat 25, 379–396 (2015).

Couture, F. et al. Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity. Biomed Res Int 2015, 824014 (2015).

Duhamel, M. et al. Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study. Mol. Cell Proteomics 14, 2857–2877 (2015).

Kara, I. et al. The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2). J. Biol. Chem. 290, 2812–2821 (2015).

Le Coupanec, A. et al. Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System. PLoS Pathog. 11, e1005261 (2015).

Levesque, C. et al. PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation. Oncotarget 6, 3680–3693 (2015).

Quanico, J. et al. Parafilm-assisted microdissection: a sampling method for mass spectrometry-based identification of differentially expressed prostate cancer protein biomarkers. Chem. Commun. (Camb.) 51, 4564–4567 (2015).

Semaan, W. et al. Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase. Biochem. Pharmacol. 94, 91–100 (2015).

Artur de Brum Fernandes

Leblanc-Trudeau, C. et al. Depressive symptoms predict future simple disease activity index scores and simple disease activity index remission in a prospective cohort of patients with early inflammatory polyarthritis. Rheumatology (Oxford) 54, 2205–2214 (2015).

Pedro d’Orléans-Juste

Bkaily, G. et al. Nuclear membrane R-type calcium channels mediate cytosolic ET-1-induced increase of nuclear calcium in human vascular smooth muscle cells. Can. J. Physiol. Pharmacol. 93, 291–297 (2015).

Boucher, J., Simard, É., Froehlich, U., D’Orléans-Juste, P. & Grandbois, M. Using carboxyfluorescein diacetate succinimidyl ester to monitor intracellular protein glycation. Anal. Biochem. 478, 73–81 (2015).

Semaan, W. et al. Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase. Biochem. Pharmacol. 94, 91–100 (2015).

Simard, E. et al. Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLoS ONE 10, e0128881 (2015).

Simplicio, J. A., Resstel, L. B., Tirapelli, D. P. C., D’Orléans-Juste, P. & Tirapelli, C. R. Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. Vascul. Pharmacol. 73, 124–137 (2015).

Yves Dory

Couture, F., Kwiatkowska, A., Dory, Y. L. & Day, R. Therapeutic uses of furin and its inhibitors: a patent review. Expert Opin Ther Pat 25, 379–396 (2015).

Zhang, H. et al. A new comonomer design for enhancing the pH-triggered LCST shift of thermosensitive polymers. Polymer Chemistry 6, 6644–6650 (2015).

Emanuel Escher

Cabana, J. et al. Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations. J. Biol. Chem. 290, 15835–15854 (2015).

Domazet, I. et al. Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity. Mol. Pharmacol. 87, 982–995 (2015).

David Fortin

Chamberland, M., Bernier, M., Fortin, D., Whittingstall, K. & Descoteaux, M. 3D interactive tractography-informed resting-state fMRI connectivity. Front Neurosci 9, 275 (2015).

Desmarais, G. et al. Cyclooxygenase-2 inhibitor prevents radiation-enhanced infiltration of F98 glioma cells in brain of Fischer rat. Int. J. Radiat. Biol. 91, 624–633 (2015).

Drapeau, A. & Fortin, D. Chemotherapy Delivery Strategies to the Central Nervous System: neither Optional nor Superfluous. Curr Cancer Drug Targets 15, 752–768 (2015).

Roy, L.-O., Poirier, M.-B. & Fortin, D. Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta. Invest New Drugs 33, 1020–1031 (2015).

Roy, L.-O., Poirier, M.-B. & Fortin, D. Transforming growth factor-beta and its implication in the malignancy of gliomas. Target Oncol 10, 1–14 (2015).

Shi, M., Fortin, D., Sanche, L. & Paquette, B. Convection-enhancement delivery of platinum-based drugs and Lipoplatin(TM) to optimize the concomitant effect with radiotherapy in F98 glioma rat model. Invest New Drugs 33, 555–563 (2015).

Tax, C. M. W. et al. Seeing More by Showing Less: Orientation-Dependent Transparency Rendering for Fiber Tractography Visualization. PLoS ONE 10, e0139434 (2015).

Luc Gaudreau

Millau, J.-F. & Gaudreau, L. Detection of Short-Range DNA Interactions in Mammalian Cells Using High-Resolution Circular Chromosome Conformation Capture Coupled to Deep Sequencing. DNA-Protein Interactions: Principles and Protocols 245–259 (2015).

Louis Gendron

Beaudry, H., Gendron, L. & Morón, J. A. Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain. Eur. J. Neurosci. 41, 901--7 (2015).

Beaudry, H. et al. Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5. Br. J. Pharmacol. 172, 2573–2587 (2015).

Bourassa, P. et al. Surgace Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells. in Label-Free Biosensor Methods in Drug Discovery (ed. Fang, Y.) 183–195 (Springer New York, 2015).

Gendron, L., Mittal, N., Beaudry, H. & Walwyn, W. Recent advances on the δ opioid receptor: from trafficking to function. Br. J. Pharmacol. 172, 403–419 (2015).

Fernand Gobeil

Bhosle, V. K., Gobeil, F., Rivera, J. C., Ribeiro-da-Silva, A. & Chemtob, S. High resolution imaging and function of nuclear G protein-coupled receptors (GPCRs). Methods Mol. Biol. 1234, 81–97 (2015).

Desposito, D. et al. Kinin receptor agonism restores hindlimb postischemic neovascularization capacity in diabetic mice. J. Pharmacol. Exp. Ther. 352, 218–226 (2015).

Regoli, D. & Gobeil, F. Critical insights into the beneficial and protective actions of the kallikrein-kinin system. Vascul. Pharmacol. 64, 1–10 (2015).

Michel Grandbois

Banville, F. A., Söllradl, T., Zermatten, P.-J., Grandbois, M. & Charette, P. G. Improved resolution in SPR and MCWG microscopy by combining images acquired with distinct mode propagation directions. Opt Lett 40, 1165–1168 (2015).

Bourassa, P. et al. Surgace Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cells. in Label-Free Biosensor Methods in Drug Discovery (ed. Fang, Y.) 183–195 (Springer New York, 2015).

Boucher, J., Simard, É., Froehlich, U., D’Orléans-Juste, P. & Grandbois, M. Using carboxyfluorescein diacetate succinimidyl ester to monitor intracellular protein glycation. Anal. Biochem. 478, 73–81 (2015).

Lacraz, G. et al. Increased Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity. PLoS ONE 10, e0136217 (2015).

Simard, E. et al. Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLoS ONE 10, e0128881 (2015).

Trensz, F. et al. Erratum to: Increased microenvironment stiffness in damaged myofibers promotes myogenic progenitor cell proliferation. Skelet Muscle 5, 31 (2015).

Trensz, F. et al. Increased microenvironment stiffness in damaged myofibers promotes myogenic progenitor cell proliferation. Skelet Muscle 5, 5 (2015).

Brigitte Guérin

Blondin, D. P. et al. Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes. Diabetes 64, 2388–2397 (2015).

Blondin, D. P. et al. Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men. J. Physiol. (Lond.) 593, 701–714 (2015).

Couture, F. et al. Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity. Biomed Res Int 2015, 824014 (2015).

Kunach, M. et al. Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans. Diabetes 64, 2432–2441 (2015).

Levesque, C. et al. PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation. Oncotarget 6, 3680–3693 (2015).

Noll, C. et al. Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects. Diabetes 64, 3690 (2015).

Selivanova, S. V. et al. Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications. J. Nucl. Med. 56, 1600–1608 (2015).

Gaétan Guillemette

Cabana, J. et al. Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations. J. Biol. Chem. 290, 15835–15854 (2015).

Domazet, I. et al. Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity. Mol. Pharmacol. 87, 982–995 (2015).

Daniel Lafontaine

Blouin, S., Craggs, T. D., Lafontaine, D. A. & Penedo, J. C. Functional Studies of DNA-Protein Interactions Using FRET Techniques. Methods Mol. Biol. 1334, 115–141 (2015).

Bordeleau, E. et al. Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile. J. Bacteriol. 197, 819–832 (2015).

Boudreault, J., Perez-Gonzalez, D. C., Penedo, J. C. & Lafontaine, D. A. Single-Molecule Approaches for the Characterization of Riboswitch Folding Mechanisms. Methods Mol. Biol. 1334, 101–107 (2015).

Chauvier, A. & Lafontaine, D. A. Probing of Nascent Riboswitch Transcripts. Methods Mol. Biol. 1334, 109–114 (2015).

Lussier, A., Bastet, L., Chauvier, A. & Lafontaine, D. A. A kissing loop is important for btuB riboswitch ligand sensing and regulatory control. J. Biol. Chem. 290, 26739–26751 (2015).

Smith-Peter, E., Lamontagne, A.-M. & Lafontaine, D. A. Role of lysine binding residues in the global folding of the lysC riboswitch. RNA Biol 12, 1372–1382 (2015).

Pierre Lavigne

Cabana, J. et al. Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations. J. Biol. Chem. 290, 15835–15854 (2015).

Domazet, I. et al. Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity. Mol. Pharmacol. 87, 982–995 (2015).

Létourneau, D., Lefebvre, A., Lavigne, P. & LeHoux, J.-G. The binding site specificity of STARD4 subfamily: Breaking the cholesterol paradigm. Mol. Cell. Endocrinol. 408, 53–61 (2015).

Li, X., Lavigne, P. & Lavoie, C. GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. Mol. Biol. Cell 26, 4412–4426 (2015).

Montpas, N. et al. Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants. Biochemistry 54, 1505–1515 (2015).

Christine Lavoie

Beaudry, H. et al. Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5. Br. J. Pharmacol. 172, 2573–2587 (2015).

Li, X., Lavigne, P. & Lavoie, C. GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. Mol. Biol. Cell 26, 4412–4426 (2015).

Traboulsi, H. et al. Macrocyclic cell penetrating peptides: a study of structure-penetration properties. Bioconjug. Chem. 26, 405–411 (2015).

Roger Lecomte

Bergeron, M. et al. LabPET II, an APD-based Detector Module with PET and Counting CT Imaging Capabilities. IEEE Transactions on Nuclear Science 62, 756–765 (2015).

Bergeron, M. et al. Improved LabPET Detectors Using (LGSO) Scintillator Blocks. IEEE Transactions on Nuclear Science 62, 36–41 (2015).

Boubacar, P., Sarrhini, O., Lecomte, R., van Lier, J. E. & Bentourkia, M. A real-time follow-up of photodynamic therapy during PET imaging. Photodiagnosis Photodyn Ther 12, 428–435 (2015).

Croteau, E. et al. Comparison of semi-automatic cardiac analysis software for the evaluation of the left ventricular ejection fraction in small animal PET. Journal of Nuclear Medicine 56, 1792–1792 (2015).

Geoffroy, C. et al. Real Time Artificial Neural Network FPGA Implementation for Triple Coincidences Recovery in PET. IEEE Transactions on Nuclear Science 62, 824–831 (2015).

Guillot, M. et al. [(18)F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain. Vet. J. 204, 299–303 (2015).

Labbé, S. M. et al. In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis. FASEB J. 29, 2046–2058 (2015).

Laprise-Pelletier, M. et al. Metal chelate grafting at the surface of mesoporous silica nanoparticles (MSNs): physico-chemical and biomedical imaging assessment. Journal of Materials Chemistry B 3, 748–758 (2015).

Michaud, J. B. et al. Sensitivity Increase Through a Neural Network Method for LOR Recovery of ICS Triple Coincidences in High-Resolution Pixelated- Detectors PET Scanners. IEEE Transactions on Nuclear Science 62, 82–94 (2015).

Poulin, É. et al. Optimization of the reference region method for dual pharmacokinetic modeling using Gd-DTPA/MRI and (18) F-FDG/PET. Magn Reson Med 73, 740–748 (2015).

Roussel, E. et al. Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism. Biomed Res Int 2015, 949624 (2015).

Selivanova, S. V. et al. Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications. J. Nucl. Med. 56, 1600–1608 (2015).

Yao, R. et al. Multipinhole SPECT helical scan parameters and imaging volume. Med Phys 42, 6599–6609 (2015).

Richard Leduc

Cabana, J. et al. Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations. J. Biol. Chem. 290, 15835–15854 (2015).

Domazet, I. et al. Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity. Mol. Pharmacol. 87, 982–995 (2015).

Fanelli, R. et al. Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues. J. Med. Chem. 58, 7785–7795 (2015).

Lecointre, C. et al. Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma. Oncogene 34, 5080–5094 (2015).

Murza, A. et al. C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action. J. Med. Chem. 58, 2431–2440 (2015).

Perreault, S. et al. Association of Treatment with Carvedilol, Bisoprolol and Metoprolol on the Risk of Mortality and Hospital Admission Among Older Adults with Heart Failure. Value Health 18, A379 (2015).

Zoratti, G. L. et al. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun 6, 6776 (2015).

Claude Legault

Basdevant, B. & Legault, C. Y. Enantioselective Iodine(III)-Mediated Synthesis of α-Tosyloxy Ketones: Breaking the Selectivity Barrier. Org. Lett. 17, 4918–4921 (2015).

Basdevant, B. & Legault, C. Y. Study of the Reactivity of [Hydroxy(tosyloxy)iodo]benzene Toward Enol Esters to Access α-Tosyloxy Ketones. J. Org. Chem. 80, 6897–6902 (2015).

Beaulieu, S. & Legault, C. Y. Mechanistic insights on the iodine(III)-mediated α-oxidation of ketones. Chemistry 21, 11206–11211 (2015).

Champagne, P. A., Drouin, M., Legault, C. Y., Audubert, C. & Paquin, J.-F. Revised mechanistic explanation for the alcohol-promoted amination of benzylic fluorides under highly concentrated conditions: Computational and experimental evidence on a model substrate. Journal of Fluorine Chemistry 171, 113–119 (2015).

Déry, M. et al. N-Heterocycles from Chromium Aminocarbenes. Organic letters 17, 1312–1315 (2015).

Jobin-Des Lauriers, A. & Legault, C. Y. Metathetical Redox Reaction of (Diacetoxyiodo)arenes and Iodoarenes. Molecules 20, 22635–22644 (2015).

Langdon, S. M., Legault, C. Y. & Gravel, M. Origin of chemoselectivity in N-heterocyclic carbene catalyzed cross-benzoin reactions: DFT and experimental insights. J. Org. Chem. 80, 3597–3610 (2015).

Petiot, P. et al. Copper-catalyzed O-arylation of N-protected 1,2-aminoalcohols using functionalized trivalent organobismuth reagents. Org. Biomol. Chem. 13, 1322–1327 (2015).

Martin Lepage

Chagnon, F. et al. Smart imaging of acute lung injury: exploration of myeloperoxidase activity using in vivo endoscopic confocal fluorescence microscopy. Am. J. Physiol. Lung Cell Mol. Physiol. 309, L543-551 (2015).

Poulin, É. et al. Optimization of the reference region method for dual pharmacokinetic modeling using Gd-DTPA/MRI and (18) F-FDG/PET. Magn Reson Med 73, 740–748 (2015).

Éric Marsault

Boulanger, S. et al. Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions. Antimicrob. Agents Chemother. 59, 7458–7464 (2015).

Chagnon, F. et al. Smart imaging of acute lung injury: exploration of myeloperoxidase activity using in vivo endoscopic confocal fluorescence microscopy. Am. J. Physiol. Lung Cell Mol. Physiol. 309, L543-551 (2015).

Murza, A. et al. C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action. J. Med. Chem. 58, 2431–2440 (2015).

Traboulsi, H. et al. Macrocyclic cell penetrating peptides: a study of structure-penetration properties. Bioconjug. Chem. 26, 405–411 (2015).

Traboulsi, H. et al. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrob. Agents Chemother. 59, 6317–6327 (2015).

Treder, A. P. et al. Solid-Phase Parallel Synthesis of Functionalised Medium-to-Large Cyclic Peptidomimetics through Three-Component Coupling Driven by Aziridine Aldehyde Dimers. Chemistry 21, 9249–9255 (2015).

Zoratti, G. L. et al. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun 6, 6776 (2015).

Rafael Najmanovich

Chartier, M. & Najmanovich, R. Detection of Binding Site Molecular Interaction Field Similarities. J Chem Inf Model 55, 1600–1615 (2015).

Frappier, V., Chartier, M. & Najmanovich, R. J. ENCoM server : exploring protein conformational space and the effect of mutations on protein function and stability. Nucleic Acids Res. 43, W395-400 (2015).

Frappier, V. & Najmanovich, R. Vibrational entropy differences between mesophile and thermophile proteins and their use in protein engineering. Protein Sci. 24, 474–483 (2015).

Gaudreault, F., Morency, L.-P. & Najmanovich, R. J. NRGsuite : a PyMOL plugin to perform docking simulations in real time using FlexAID. Bioinformatics 31, 3856–3858 (2015).

Gaudreault, F. & Najmanovich, R. J. FlexAID : Revisiting Docking on Non-Native-Complex Structures. J Chem Inf Model 55, 1323–1336 (2015).

Samish, I., Bourne, P. E. & Najmanovich, R. J. Achievements and challenges in structural bioinformatics and computational biophysics. Bioinformatics 31, 146–150 (2015).

Jean-Luc Parent

Beaudry, H. et al. Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5. Br. J. Pharmacol. 172, 2573–2587 (2015).

Binda, C. & Parent, J.-L. Characterization of the interaction between the prostaglandin D2 DP1 receptor and the intracellular L-prostaglandin D synthase. Methods Mol. Biol. 1234, 53–67 (2015).

Marek Rola Pleszczynski

Thivierge, M., Turcotte, S., Rola-Pleszczynski, M. & Stankova, J. Enhanced cysteinyl-leukotriene type 1 receptor expression in T cells from house dust mite-allergic individuals following stimulation with Der p. J Immunol Res 2015, 384780 (2015).

Wang, M., Mostafa El-Maghraby, N., Turcotte, S., Rola-Pleszczynski, M. & Stankova, J. Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and Migration. Mediators Inflamm. 2015, 389849 (2015).

Philippe Sarret

Brial, F., Lussier, C. R., Belleville, K., Sarret, P. & Boudreau, F. Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)-Deficient Mice. Diabetes 64, 3314–3320 (2015).

Fanelli, R. et al. Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues. J. Med. Chem. 58, 7785–7795 (2015).

Murza, A. et al. C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action. J. Med. Chem. 58, 2431–2440 (2015).

Parent, A. J. et al. Relationship between blood- and cerebrospinal fluid-bound neurotransmitter concentrations and conditioned pain modulation in pain-free and chronic pain subjects. J Pain 16, 436–444 (2015).

Thomas, J. B. et al. Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Bioorg. Med. Chem. Lett. 25, 292–296 (2015).

Thomas, J. B. et al. The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2. Bioorg. Med. Chem. Lett. 25, 2060–2064 (2015).

Claude Spino

Déry, M. et al. N-Heterocycles from Chromium Aminocarbenes. Organic letters 17, 1312–1315 (2015).

Jana Stankova

Thivierge, M., Turcotte, S., Rola-Pleszczynski, M. & Stankova, J. Enhanced cysteinyl-leukotriene type 1 receptor expression in T cells from house dust mite-allergic individuals following stimulation with Der pJ Immunol Res 2015, 384780 (2015).

Wang, M., Mostafa El-Maghraby, N., Turcotte, S., Rola-Pleszczynski, M. & Stankova, J. Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and MigrationMediators Inflamm. 2015, 389849 (2015).

Yue Zhao

Fu, S. & Zhao, Y. Orientation of Azobenzene Mesogens in Side-Chain Liquid Crystalline Polymers: Interplay between Effects of Mechanical Stretching, Photoisomerization and Thermal Annealing. Macromolecules 48, 5088–5098 (2015).

Li, G., Yan, Q., Xia, H. & Zhao, Y. Therapeutic-Ultrasound-Triggered Shape Memory of a Melamine-Enhanced Poly (vinyl alcohol) Physical Hydrogel. ACS applied materials & interfaces 7, 12067–12073 (2015).

Li, G., Zhang, H., Fortin, D., Xia, H. & Zhao, Y. Poly (vinyl alcohol)–Poly (ethylene glycol) Double-Network Hydrogel: A General Approach to Shape Memory and Self-Healing Functionalities. Langmuir 31, 11709–11716 (2015).

Tong, X. et al. Anisotropic optical properties of oriented silver nanorice and nanocarrots in stretched polymer films. Nanoscale 7, 8858–8863 (2015).

Xu, Z. et al. Microfluidic Synthesis of Photoresponsive Spool-Like Block Copolymer Nanoparticles: Flow-Directed Formation and Light-Triggered Dissociation. Chem. Mater. 27, 8094–8104 (2015).

Yan, Q. & Zhao, Y. ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies. Chemical Science 6, 4343–4349 (2015).

Zhang, H. et al. A new comonomer design for enhancing the pH-triggered LCST shift of thermosensitive polymers. Polymer Chemistry 6, 6644–6650 (2015).