Publications 2014

M’Hamed Bentourkia

Khalil, A., Orellana, M. R. M., Fulop, T., Turcotte, E. E. & Bentourkia, M. Positron emission tomography imaging for vascular inflammation evaluation in elderly subjects with different risk factors for cardiovascular diseases. Am J Nucl Med Mol Imaging 4, 283–292 (2014).

Guylain Boulay

Chevallet, M. et al. Functional consequences of the over-expression of TRPC6 channels in HEK cells: impact on the homeostasis of zinc. Metallomics 6, 1269–1276 (2014).

André Cantin

Fugère, A. et al. Interspecific small molecule interactions between clinical isolates of Pseudomonas aeruginosa and Staphylococcus aureus from adult cystic fibrosis patients. PLoS ONE 9, e86705 (2014).

Marois, I. et al. Inhibition of influenza virus replication by targeting broad host cell pathways. PLoS ONE 9, e110631 (2014).

Paul Charette

Bussonnière, A. et al. Cell detachment and label-free cell sorting using modulated surface acoustic waves (SAWs) in droplet-based microfluidics. Lab Chip 14, 3556–3563 (2014).

Courcier, T. et al. CMOS BQJ detector chip with integrated charge-amplifiers for fluorescence measurements. Sensors and Actuators, B: Chemical 190, 288–294 (2014).

Courcier, T., Pittet, P., Charette, P. G., Aimez, V. & Lu, G. N. BQJ photodetector signal processing. In Key Engineering Materials 605, 91–94 (Trans Tech Publ, 2014).

Robert Day

Couture, F. et al. PACE4-based molecular targeting of prostate cancer using an engineered 64Cu-radiolabeled peptide inhibitor. Neoplasia 16, 634–643 (2014).

D’Anjou, F., Couture, F., Desjardins, R. & Day, R. Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells. Methods Mol. Biol. 1103, 67–82 (2014).

Gagnon, H. et al. Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin. J. Med. Chem. 57, 29–41 (2014).

Kwiatkowska, A. et al. Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J. Med. Chem. 57, 98–109 (2014).

Longuespée, R. et al. Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target. Transl Oncol (2014).

Longuespée, R. et al. HFIP extraction followed by 2D CTAB/SDS-PAGE separation: a new methodology for protein identification from tissue sections after MALDI mass spectrometry profiling for personalized medicine research. OMICS 18, 374–384 (2014).

Ly, K. et al. Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9. J. Biol. Chem. 289, 17732–17746 (2014).

Artur de Brum Fernandes

Allard-Chamard, H., Dufort, P., Haroun, S. & de Brum-Fernandes, A. J. Cytosolic phospholipase A2 and eicosanoids modulate life, death and function of human osteoclasts in vitro. Prostaglandins Leukot. Essent. Fatty Acids 90, 117–123 (2014).

Allard-Chamard, H., Haroun, S. & de Brum-Fernandes, A. J. Secreted phospholipase A2 type II is present in Paget’s disease of bone and modulates osteoclastogenesis, apoptosis and bone resorption of human osteoclasts independently of its catalytic activity in vitro. Prostaglandins Leukot. Essent. Fatty Acids 90, 39–45 (2014).

Jones, J. D. et al. Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels. Arthritis Res. Ther. 16, R103 (2014).

Yue, L., Haroun, S., Parent, J.-L. & de Brum-Fernandes, A. J. Prostaglandin D(2) induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways. Bone 60, 112–121 (2014).

Jean-Bernard Denault

Boucher, D., Duclos, C. & Denault, J.-B. General in vitro caspase assay procedures. Methods Mol. Biol. 1133, 3–39 (2014).

Yves Dory

Baillargeon, P., Lussier, T. & Dory, Y. L. Hydrogen Bonds between Acidic Protons from Alkynes and Amides and Carbonyl Oxygen Atoms as Acceptor Partners. Journal of Crystallography 2014, 5 (2014).

Gagnon, H. et al. Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxinJ. Med. Chem. 57, 29–41 (2014).

Kwiatkowska, A. et al. Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J. Med. Chem. 57, 98–109 (2014).

Yan, L.-H., Skiredj, A., Dory, Y., Delpech, B. & Poupon, E. 5-Aminopenta-2,4-dienals: Synthesis, Activation towards Nucleophiles, Molecular Modeling and Biosynthetic Implications in Relation to the Manzamine Alkaloids. European Journal of Organic Chemistry 2014, 4973–4984 (2014).

Emanuel Escher

Sainsily, X. et al. Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor. Biochem. Pharmacol. 92, 280–288 (2014).

David Fortin

Blanchette, M., Tremblay, L., Lepage, M. & Fortin, D. Impact of drug size on brain tumor and brain parenchyma delivery after a blood-brain barrier disruption. J. Cereb. Blood Flow Metab. 34, 820–826 (2014).

Chamberland, M., Whittingstall, K., Fortin, D., Mathieu, D. & Descoteaux, M. Real-time multi-peak tractography for instantaneous connectivity display. Front Neuroinform 8, 59 (2014).

Fortin, D., Morin, P.-A., Belzile, F., Mathieu, D. & Paré, F.-M. Intra-arterial carboplatin as a salvage strategy in the treatment of recurrent glioblastoma multiforme. J. Neurooncol. 119, 397–403 (2014).

Gadji, M. et al. A new der(1;7)(q10;p10) leading to a singular 1p loss in a case of glioblastoma with oligodendroglioma component. Neuropathology 34, 170–178 (2014).

Whittingstall, K., Bernier, M., Houde, J.-C., Fortin, D. & Descoteaux, M. Structural network underlying visuospatial imagery in humans. Cortex 56, 85–98 (2014).

Luc Gaudreau

L’Héritier, F., Marques, M., Fauteux, M. & Gaudreau, L. Defining molecular sensors to assess long-term effects of pesticides on carcinogenesis. International journal of molecular sciences 15, 17148–17161 (2014).

Marques, M. et al. Low levels of 3, 3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol. BMC cancer 14, 524 (2014).

Louis Gendron

Bourassa, P., Tudashki, H. B., Pineyro, G., Grandbois, M. & Gendron, L. Label-free monitoring of μ-opioid receptor-mediated signaling. Mol. Pharmacol. 86, 138–149 (2014).

Desroches, J., Bouchard, J.-F., Gendron, L. & Beaulieu, P. Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia. Neuroscience 261, 23–42 (2014).

Thomas, J. B. et al. Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. J. Med. Chem. 57, 5318–5332 (2014).

Thomas, J. B. et al. Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J. Med. Chem. 57, 7472–7477 (2014).

Fernand Gobeil

Gobeil, F., Sirois, P. & Regoli, D. Preclinical pharmacology, metabolic stability, pharmacokinetics and toxicology of the peptidic kinin B1 receptor antagonist R-954. Peptides 52, 82–89 (2014).

Joyal, J.-S. et al. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat. Med. 20, 1165–1173 (2014).

Michel Grandbois

Boucher, J., Simard, E., Froehlich, U. & Grandbois, M. Amplification of AngII-dependent cell contraction by glyoxal: implication of cell mechanical properties and actomyosin activityIntegr Biol (Camb) 6, 411–421 (2014).

Bourassa, P., Tudashki, H. B., Pineyro, G., Grandbois, M. & Gendron, L. Label-free monitoring of μ-opioid receptor-mediated signaling. Mol. Pharmacol. 86, 138–149 (2014).

Bussonnière, A. et al. Cell detachment and label-free cell sorting using modulated surface acoustic waves (SAWs) in droplet-based microfluidics. Lab Chip 14, 3556–3563 (2014).

Brigitte Guérin

Ait-Mohand, S., Denis, C., Tremblay, G., Paquette, M. & Guérin, B. Development of bifunctional chelates bearing hydroxamate arms for highly efficient (64)Cu radiolabeling. Org. Lett. 16, 4512–4515 (2014).

Blondin, D. P. et al. Increased brown adipose tissue oxidative capacity in cold-acclimated humans. J. Clin. Endocrinol. Metab. 99, E438-446 (2014).

Couture, F. et al. PACE4-based molecular targeting of prostate cancer using an engineered 64Cu-radiolabeled peptide inhibitor. Neoplasia 16, 634–643 (2014).

Labbé, S. M. et al. Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance. Am. J. Physiol. Endocrinol. Metab. 306, E1388-1396 (2014).

Gaétan Guillemette

Béliveau, É., Lessard, V. & Guillemette, G. STIM1 positively regulates the Ca2+ release activity of the inositol 1,4,5-trisphosphate receptor in bovine aortic endothelial cells. PLoS ONE 9, e114718 (2014).

Daniel Lafontaine

Colizzi, F., Lamontagne, A.-M., Lafontaine, D. A. & Bussi, G. Probing riboswitch binding sites with molecular docking, focused libraries, and in-line probing assays. Methods Mol. Biol. 1103, 141–151 (2014).

Eschbach, S. H. & Lafontaine, D. A. RNA conformational changes analyzed by comparative gel electrophoresis. Methods Mol. Biol. 1086, 255–264 (2014).

McCluskey, K., Shaw, E., Lafontaine, D. A. & Penedo, J. C. Single-molecule fluorescence of nucleic acids. Methods Mol. Biol. 1076, 759–791 (2014).

Shaw, E., St-Pierre, P., McCluskey, K., Lafontaine, D. A. & Penedo, J. C. Using sm-FRET and denaturants to reveal folding landscapes. Meth. Enzymol. 549, 313–341 (2014).

St-Pierre, P., McCluskey, K., Shaw, E., Penedo, J. C. & Lafontaine, D. A. Fluorescence tools to investigate riboswitch structural dynamics. Biochim. Biophys. Acta 1839, 1005–1019 (2014).

Pierre Lavigne

Béland, M., Bédard, M., Tremblay, G., Lavigne, P. & Roucou, X. Aβ induces its own prion protein N-terminal fragment (PrPN1)-mediated neutralization in amorphous aggregates. Neurobiol. Aging 35, 1537–1548 (2014).

Sainsily, X. et al. Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor. Biochem. Pharmacol. 92, 280–288 (2014).

Christine Lavoie

Rosciglione, S., Thériault, C., Boily, M.-O., Paquette, M. & Lavoie, C. Gαs regulates the post-endocytic sorting of G protein-coupled receptors. Nat Commun 5, 4556 (2014).

Roger Lecomte

Bergeron, M. et al. Imaging performance of LabPET APD-based digital PET scanners for pre-clinical research. Phys Med Biol 59, 661–678 (2014).

Cadorette, J. et al. Comment on ‘Temperature dependence of APD-based PET scanners’ [Med. Phys. 40(9) 092506 (13pp.) (2013)]. Med Phys 41, 017101 (2014).

Cauchon, N., Hasséssian, H. M., Turcotte, E., Lecomte, R. & Van Lier, J. E. Deciphering PDT-induced inflammatory responses using real-time FDG-PET in a mouse tumour model. Photochem. Photobiol. Sci. 13, 1434–1443 (2014).

Charest, J. et al. Automatic Channel Fault Detection on a Small Animal APD-Based Digital PET Scanner. IEEE Transactions on Nuclear Science 61, 2494–2502 (2014).

Corbeil Therrien, A. et al. Modeling of Single Photon Avalanche Diode Array Detectors for PET Applications. IEEE Transactions on Nuclear Science 61, 14–22 (2014).

Croteau, E. et al. Arterial input function sampling without surgery in rats for positron emission tomography molecular imaging. Nucl Med Commun 35, 666–676 (2014).

Croteau, E. et al. [(11)C]-Acetoacetate PET imaging: a potential early marker for cardiac heart failure. Nucl. Med. Biol. 41, 863–870 (2014).

Di, L.-Z. et al. A Longitudinal Low Dose µCT Analysis of Bone Healing in Mice: A Pilot Study. Advances in Orthopedics. (2014).

Lachance, D. et al. Endurance training or beta-blockade can partially block the energy metabolism remodeling taking place in experimental chronic left ventricle volume overload. BMC Cardiovasc Disord 14, 190 (2014).

Richard Leduc

Barré, O. et al. Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries. PLoS ONE 9, e105984 (2014).

Brulé, C. et al. Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors. FASEB J. 28, 5148–5162 (2014).

Demeule, M. et al. Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. J. Clin. Invest. 124, 1199–1213 (2014).

Duchêne, D. et al. Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2. J. Med. Chem. 57, 10198–10204 (2014).

Sainsily, X. et al. Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor. Biochem. Pharmacol. 92, 280–288 (2014).

Tang, X. et al. Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis. Oncotarget 5, 1352–1362 (2014).

Claude Legault

Ba, S. et al. Synthesis and characterization of combined cross-linked laccase and tyrosinase aggregates transforming acetaminophen as a model phenolic compound in wastewaters. Sci. Total Environ. 487, 748–755 (2014).

Haroune, L., Salaun, M., Ménard, A., Legault, C. Y. & Bellenger, J.-P. Photocatalytic degradation of carbamazepine and three derivatives using TiO₂ and ZnO: effect of pH, ionic strength, and natural organic matter. Sci. Total Environ. 475, 16–22 (2014).

Schneider, Y., Prévost, J., Gobin, M. & Legault, C. Y. Diazirines as potent electrophilic nitrogen sources: application to the synthesis of pyrazoles. Org. Lett. 16, 596–599 (2014).

Martin Lepage

Blanchette, M., Tremblay, L., Lepage, M. & Fortin, D. Impact of drug size on brain tumor and brain parenchyma delivery after a blood-brain barrier disruption. J. Cereb. Blood Flow Metab. 34, 820–826 (2014).

Croteau, E. et al. Arterial input function sampling without surgery in rats for positron emission tomography molecular imaging. Nucl Med Commun 35, 666–676 (2014).

Lebel, R. & Lepage, M. A comprehensive review on controls in molecular imaging: lessons from MMP-2 imaging. Contrast Media Mol Imaging 9, 187–210 (2014).

Nugent, S. et al. Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults. Am. J. Physiol. Endocrinol. Metab. 306, E1315-1321 (2014).

Nugent, S. et al. Brain glucose and acetoacetate metabolism: a comparison of young and older adults. Neurobiol. Aging 35, 1386–1395 (2014).

Éric Marsault

Chagnon, F. et al. Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus. Eur J Med Chem 80, 605–620 (2014).

Demeule, M. et al. Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. J. Clin. Invest. 124, 1199–1213 (2014).

Duchêne, D. et al. Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2. J. Med. Chem. 57, 10198–10204 (2014).

Murza, A., Belleville, K., Longpré, J.-M., Sarret, P. & Marsault, É. Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid. Biopolymers 102, 297–303 (2014).

Treder, A. P., Tremblay, M.-C., Yudin, A. K. & Marsault, E. Solid-phase synthesis of piperazinones via disrupted Ugi condensation. Org. Lett. 16, 4674–4677 (2014).

Tremblay, H. et al. One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative properties. Bioorg. Med. Chem. Lett. 24, 5635–5638 (2014).

Rafael Najmanovich

Duchêne, D. et al. Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2. J. Med. Chem. 57, 10198–10204 (2014).

Frappier, V. & Najmanovich, R. J. A coarse-grained elastic network atom contact model and its use in the simulation of protein dynamics and the prediction of the effect of mutations. PLoS Comput. Biol. 10, e1003569 (2014).

Glouzon, J.-P. S., Bolduc, F., Wang, S., Najmanovich, R. J. & Perreault, J.-P. Deep-sequencing of the peach latent mosaic viroid reveals new aspects of population heterogeneity. PLoS ONE 9, e87297 (2014).

Larocque, M., Chénard, T. & Najmanovich, R. A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors. BMC Syst Biol 8, 117 (2014).

Jean-Luc Parent

Binda, C. et al. A G protein-coupled receptor and the intracellular synthase of its agonist functionally cooperate. J. Cell Biol. 204, 377–393 (2014).

Lachance, V., Angers, S. & Parent, J.-L. New insights in the regulation of Rab GTPases by G protein-coupled receptors. Small GTPases (2014).

Lachance, V. et al. Ubiquitylation and activation of a Rab GTPase is promoted by a β₂AR-HACE1 complex. J. Cell. Sci. 127, 111–123 (2014).

Yue, L., Haroun, S., Parent, J.-L. & de Brum-Fernandes, A. J. Prostaglandin D(2) induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways. Bone 60, 112–121 (2014).

Marek Rola Pleszczynski

Berthiaume, M., Rousseau, É., Rola-Pleszczynski, M. & Pasquier, J.-C. Rapid evaluation of the absence of inflammation after rupture of membranes. J. Matern. Fetal. Neonatal. Med. 27, 865–869 (2014).

Ramanathan, S. et al. Interleukin-15 in the Regulation of Obesity and Fatty Liver Disease. Journal of Clinical and Experimental Hepatology 4, S32 (2014).

Philippe Sarret

Beaudet, N., Courteau, J., Sarret, P. & Vanasse, A. Improving the selection of true incident cases of low back pain by screening retrospective administrative data. Eur J Pain 18, 923–931 (2014).

Belkouch, M. et al. Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation. J Neuroinflammation 11, 45 (2014).

Demeule, M. et al. Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. J. Clin. Invest. 124, 1199–1213 (2014).

Deslauriers, J., Racine, W., Sarret, P. & Grignon, S. Preventive effect of α-lipoic acid on prepulse inhibition deficits in a juvenile two-hit model of schizophrenia. Neuroscience 272, 261–270 (2014).

Deslauriers, J., Desmarais, C., Sarret, P. & Grignon, S. Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of (±)-α-lipoic acid in SH-SY5Y neuroblastoma cells. J. Mol. Neurosci. 52, 378–383 (2014).

Murza, A., Belleville, K., Longpré, J.-M., Sarret, P. & Marsault, É. Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid. Biopolymers 102, 297–303 (2014).

Thomas, J. B. et al. Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. J. Med. Chem. 57, 5318–5332 (2014).

Thomas, J. B. et al. Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J. Med. Chem. 57, 7472–7477 (2014).

Claude Spino

Spino, C. Modern Methods in Stereoselective Aldol Reactions. Edited by Rainer Mahrwald. Angew. Chem. Int. Ed. 53, 5498–5498 (2014).

Jana Stankova

Binda, C. et al. A G protein-coupled receptor and the intracellular synthase of its agonist functionally cooperate. J. Cell Biol. 204, 377–393 (2014).

Yue Zhao

Fan, W., Tong, X., Yan, Q., Fu, S. & Zhao, Y. Photodegradable and size-tunable single-chain nanoparticles prepared from a single main-chain coumarin-containing polymer precursor. Chemical Communications 50, 13492–13494 (2014).

He, J., Tremblay, L., Lacelle, S. & Zhao, Y. How can photoisomerization of azobenzene induce a large cloud point temperature shift of PNIPAM? Polymer Chemistry 5, 5403–5411 (2014).

Lu, X., Fei, G., Xia, H. & Zhao, Y. Ultrasound healable shape memory dynamic polymers. Journal of Materials Chemistry A 2, 16051–16060 (2014).

Shi, F. & Zhao, Y. Sub-10 nm and monodisperse β-NaYF 4: Yb, Tm, Gd nanocrystals with intense ultraviolet upconversion luminescence. Journal of Materials Chemistry C 2, 2198–2203 (2014).

Yan, Q., Zhang, H. & Zhao, Y. CO2-switchable supramolecular block glycopolypeptide assemblies. ACS Macro Letters 3, 472–476 (2014).

Yan, Q. & Zhao, Y. Block copolymer self-assembly controlled by the ‘green’ gas stimulus of carbon dioxide. Chemical Communications 50, 11631–11641 (2014).

Yan, Q. & Zhao, Y. Recent advances of CO2-responsive polymers and their applications. Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering 30, 170–178 (2014).

Zhang, H. et al. Light-healable hard hydrogels through photothermally induced melting–crystallization phase transition. Journal of Materials Chemistry A 2, 13373–13379 (2014).

Zhang, H., Xia, H. & Zhao, Y. Light-controlled complex deformation and motion of shape-memory polymers using a temperature gradient. ACS Macro Letters 3, 940–943 (2014).

Zhang, H., Tong, X. & Zhao, Y. Diverse thermoresponsive behaviors of uncharged UCST block copolymer micelles in physiological medium. Langmuir 30, 11433–11441 (2014).