Voici la liste des publications récentes des professeurs du service de pneumologie du Département de médecine. Les cliniciens et les professeurs-chercheurs avec octrois de ce service sont en caractères gras. Les professeurs associés à ce service sont en italique.

Dernière mise à jour : 11 jan 2021


1.      Archambault, A.-S., S. Poirier, J.-S. Lefebvre, P.-P. Robichaud, M.-C. Larose, C. Turcotte, C. Martin, McDonald P P et al. « 20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4-mediated responses of human neutrophils and eosinophils ». Journal of Leukocyte Biology 105, no 6 (2019): 1131‑42.

2.      Bergeron, C., et Cantin AM . « Cystic Fibrosis: Pathophysiology of Lung Disease ». Seminars in Respiratory and Critical Care Medicine 40, no 6 (2019): 715‑26.

3.      Blanchard, A., et N. Bouchard. « Pembrolizumab-induced obstructive bronchiolitis in a patient with stage IV non-small-cell lung cancer ». Current Oncology 26, no 4 (2019): e571‑73.

4.       Boulkeroua, C., H. Ayari, T. Khalfaoui, M. Lafrance, É. Besserer-Offroy, N. Ekindi, R. Sabbagh, Lesur O, et al. « Apelin-13 regulates vasopressin-induced aquaporin-2 expression and trafficking in kidney collecting duct cells ». Cellular Physiology and Biochemistry 53, no 4 (2019): 687‑700.

5.      Couëtoux du Tertre MMarques MTremblay LBouchard NDiaconescu RBlais NCouture CPelsser V et al (2019) « Analysis of the Genomic Landscape in ALK+ NSCLC Patients Identifies Novel Aberrations Associated with Clinical Outcomes. - Mol Cancer Ther.  Sep;18(9):1628-1636. https://doi/10.1158/1535-7163.MCT-19-0105.

6.      Couillard S, Bélanger M, Bouchard N, 2019 Q Fever Presenting as Miliary Pneumonia: Case imagery and differential diagnosisCanadian Journal of Respiratory, Critical Care, and Sleep Medicine Vol 3, issue 9

7.      Cantin, A.M « Cystic Fibrosis Lung Disease and Immunometabolism. Targeting the NLRP3 Inflammasome ». American Journal of Respiratory and Critical Care Medicine 200, no 11 (1 décembre 2019): 1335‑37.

8.      Jeukens, J., L. Freschi, I. Kukavica-Ibrulj, J.-G. Emond-Rheault, C. Allard, J. Barbeau, Cantin A M, et al. 2019. « The Pseudomonas aeruginosa Population among Cystic Fibrosis Patients in Quebec, Canada: A disease hot spot without known epidemic isolates ». Journal of Clinical Microbiology 57 (6).

9.      Kaplan, A., P. Arsenault, B. Aw, V. Brown, G. Fox, R. Grossman, T. Jadavji, Poulin Y et al. « Vaccine strategies for prevention of community-acquired pneumonia in Canada Who would benefit most from pneumococcal immunization? » Canadian Family Physician 65, no 9 (2019): 625‑33.

10.  Khalil, N., Manganas, H., Ryerson, C.J., Shapera, S., Cantin, A.M., Hernandez, P., Turcotte, E.E., Parker, J.M., Moran, J.E., Albert, G.R., Sawtell, R., Hagerimana, A., Laurin, P., Gagnon, L., Cesari, F., Kolb, M., 2019. Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis. European Respiratory Journal 53.

11.  Li, Q. Larivée P, J. Courteau, S. Couillard, T.G. Poder, N. Carrier, M. Bélanger, et A. Vanasse. « Greater eosinophil counts at first COPD hospitalization are associated with more readmissions and fewer deaths ». International Journal of COPD 14 (2019): 331‑41.

12.  Marsault, E., C. Llorens-Cortes, X. Iturrioz, H.J. Chun, Lesur O, G.Y. Oudit, et Auger-Messier M. The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders. Annals of the New York Academy of Sciences, 2019.

13.  Millette, G. ,Langlois, J.-P,Brouillette, E. ,Frost, E.H. ,Cantin, A.M. Malouin, F

Despite Antagonism in vitro, Pseudomonas aeruginosa Enhances Staphylococcus aureus Colonization in a Murine Lung Infection Model . Frontier in microbiology, 10; 13 2019


14.  Murza, A., K. Trân, L. Bruneau-Cossette, O. Lesur, Auger-Messier M, Lavigne, P. Sarret, et É. Marsault. « Apelins, ELABELA, and their derivatives: Peptidic regulators of the cardiovascular system and beyond ». Peptide Science 111, no 1 (2019).


  • Besserer-Offroy, Élie, Patrick Bérubé, Jérôme Côté, Alexandre Murza, Jean-Michel Longpré, Robert Dumaine, Olivier Lesur, Mannix Auger-Messier « The Hypotensive Effect of Activated Apelin Receptor Is Correlated with β-Arrestin Recruitment ». Pharmacological Research 131 (9 mars 2018): 7‑16.
  • Cantin, A.M. « Low-hanging fruit and antioxidant therapy in cystic fibrosis ». American Journal of Respiratory and Critical Care Medicine 198, no 5 (2018): 555‑57.
  • Coquerel, David, Xavier Sainsily, Lauralyne Dumont, Philippe Sarret, Éric Marsault, Mannix Auger-Messier, et Olivier Lesur. « The Apelinergic System as an Alternative to Catecholamines in Low-Output Septic Shock ». Critical Care (London, England) 22, no 1 (19 janvier 2018): 10.
  • Grégoire, Marie-Chantal, Frédéric Leduc, Martin H. Morin, Tiphanie Cavé, Mélina Arguin, Martin Richter, Pierre-Étienne Jacques, et Guylain Boissonneault. « The DNA Double-Strand “Breakome” of Mouse Spermatids ». Cellular and Molecular Life Sciences: CMLS, 7 février 2018.
  • Lesur, O., Delile, E., Asfar, P., Radermacher, P., 2018. Hemodynamic support in the early phase of septic shock: a review of challenges and unanswered questions. Ann Intensive Care 8, 102.
  • Matthes, E., J.W. Hanrahan, et A.M. Cantin. « F508del-CFTR is not corrected by thymosin α1 ». Nature Medicine 24, no 7 (2018): 890‑91.
  • Morin, Caroline, André M. Cantin, Félix-Antoine Vézina, et Samuel Fortin. « The Efficacy of MAG-DHA for Correcting AA/DHA Imbalance of Cystic Fibrosis Patients ». Marine Drugs 16, no 6 (26 mai 2018).
  • Perez, J.R., N. Ybarra, F. Chagnon, O. Lesur, J. Seuntjens, et I.E. Naqa. « Fluorescence Endomicroscopy Imaging of Mesenchymal Stem Cells in the Rat Lung ». Current Protocols in Stem Cell Biology 45, no 1 (2018).      
  • Pittman, N, SM Rawn, M Wang, A Masseto, KA Beattie, et M Larché. « Treatment of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review. Rheumatology 1; 57 (10): 1802-1811.
  • Poder, T.G., N. Carrier, M. Bélanger, S. Couillard, J. Courteau, P. Larivée, et A. Vanasse. « Eosinophil counts in first COPD hospitalizations: a 1-year cost analysis in Quebec, Canada ». International journal of chronic obstructive pulmonary disease 13 (2018): 3065‑76.
  • Tatsiy, O., et P.P. McDonald. « Physiological stimuli induce PAD4-Dependent, ROS-Independent NETosis, with early and late events controlled by discrete signaling pathways ». Frontiers in Immunology 9, no SEP (2018).
  • Trân, Kien, Alexandre Murza, Xavier Sainsily, David Coquerel, Jérôme Côté, Karine Belleville, Lounès Haroune,  Lesur O, Auger-Messier MSarret PMarsault É. « A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects ». Journal of Medicinal Chemistry 61, no 6 (22 mars 2018): 2266‑77.


Boyapelly, K., Bonin, M.-A., Traboulsi, H., Cloutier, A., Phaneuf, S.C., Fortin, D., Cantin, A.M., Richter, M. V., Marsault, E., 2017. Synthesis and Characterization of a Phosphate Prodrug of Isoliquiritigenin. J. Nat. Prod. 80, 879–886. 

Cantin, A.M., Hanrahan, J.W., 2017. Thymosin α1: a single drug with multiple targets in cystic fibrosis. Nat. Med. 23, 536–538. 

Chagnon, F., Coquerel, D., Salvail, D., Marsault, E., Dumaine, R., Auger-Messier, M., Sarret, P., Lesur, O., 2017. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit. Care Med. 45, e391–e398. 

Coquerel, D., Chagnon, F., Sainsily, X., Dumont, L., Murza, A., Côté, J., Dumaine, R., Sarret, P., Marsault, É., Salvail, D., Auger-Messier, M., Lesur, O., (2017). ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock. Crit. Care Med. 45(11):e1139–e1148. URL:

Couillard, S., Larivée, P., Courteau, J., Vanasse, A., 2017. Eosinophils in COPD Exacerbations Are Associated With Increased Readmissions. Chest 151, 366–373. 

Ear, T., Tatsiy, O., Allard, F.L., McDonald, P.P., 2017. Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils. J. Immunol. Res. 2017, 4347121. 

Lacasse, Y., Bernard, S., Sériès, F., Nguyen, V.H., Bourbeau, J., Aaron, S., Maltais, F., the International Nocturnal Oxygen (INOX) Research Group [Larivée, P], 2017. Multi-center, randomized, placebo-controlled trial of nocturnal oxygen therapy in chronic obstructive pulmonary disease: a study protocol for the INOX trial. BMC Pulm. Med. 17, 8. 

Murza, A., Sainsily, X., Côté, J., Bruneau-Cossette, L., Besserer-Offroy, É., Longpré, J.-M., Leduc, R., Dumaine, R., Lesur, O., Auger-Messier, M., Sarret, P., Marsault, É., 2017. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org. Biomol. Chem. 15, 449–458. 

Perez, J.R., Ybarra, N., Chagnon, F., Serban, M., Lee, S., Seuntjens, J., Lesur, O., El Naqa, I., 2017. Tracking of Mesenchymal Stem Cells with Fluorescence Endomicroscopy Imaging in Radiotherapy-Induced Lung Injury. Sci. Rep. 7, 40748. 

Rodrigue, C., Beauchesne, M.-F., Mallette, V., Lemière, C., Larivée, P., Blais, L., 2017. Characterization of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: A Qualitative Analysis. COPD 14, 330–338. 

Vanasse, A., Courteau, J., Couillard, S., Beauchesne, M.-F.,Larivée, P., (2017). Predicting One-year Mortality After a “First” Hospitalization for Chronic Obstructive Pulmonary Disease: An Eight-Variable Assessment Score Tool. COPD 14(5):490–497. URL:

[1] Les publications issues d’une collaboration inter-services sont répertoriées dans chacun des services impliqués.

[2] La liste des auteurs a parfois été raccourcie par […] ou et al. par soucis d’espace.


Cantin, A.M., 2016. Cystic Fibrosis Transmembrane Conductance Regulator. Implications in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. Ann. Am. Thorac. Soc. 13 Suppl 2, S150-5.

Charbonneau, M., Lavoie, R.R., Lauzier, A., Harper, K., McDonald, P.P., Dubois, C.M., 2016. Platelet-Derived Growth Factor Receptor Activation Promotes the Prodestructive Invadosome-Forming Phenotype of Synoviocytes from Patients with Rheumatoid Arthritis. J. Immunol. 196, 3264–3275.         

Deny, L.J., Traboulsi, H., Cantin, A.M., Marsault, É., Richter, M. V., Bélanger, G., 2016. Bis-Michael Acceptors as Novel Probes to Study the Keap1/Nrf2/ARE Pathway. J. Med. Chem. 59, 9431–9442.  

Dumas, E., Neagoe, P.-E., McDonald, P.P., White, M., Sirois, M.G., 2016. New Insights into the Pro-Inflammatory Activities of Ang1 on Neutrophils: Induction of MIP-1β Synthesis and Release. PLoS One 11, e0163140.

Grondin Beaudoin, B., Chartrand-Lefebvre, C., Girard, M., 2016. Comparison of Four Scores for Ultrasound Assessment of Pulmonary Aeration. Am. J. Respir. Crit. Care Med. 193, A5156.          

Murza, A., Sainsily, X., Coquerel, D., Côté, J., Marx, P., Besserer-Offroy, É., Longpré, J.-M., Lainé, J., Reversade, B., Salvail, D., Leduc, R., Dumaine, R., Lesur, O., Auger-Messier, M., Sarret, P., Marsault, É., 2016. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions. J. Med. Chem. 59, 2962–72.     

Rodrigue, C., Beauchesne, M.-F., Savaria, F., Forget, A., Lemière, C., Larivée, P., Blais, L., RESP Investigators, 2016. Adverse events among COPD patients treated with long-acting anticholinergics and β2-agonists in an outpatient respiratory clinic. Respir. Med. 113, 65–73.         

Wanner, A., Boucher, R., Cantin, A., Kelsen, S., 2016. A Word from the Scientific Committee. 14th Gordon L. Snider Critical Issues Workshop. Ann. Am. Thorac. Soc. 13 Suppl 2, S111.

Ziai, S., Coriati, A., St-Pierre, D., Chabot, K., Desjardins, K., Leroux, C., Richter, M. V., Rabasa-Lhoret, R., 2016. Glucose Fluctuations are Not Modulated by the Proportion of Calories from Macronutrients or Spontaneous Total Energy Expenditure in Adults with Cystic Fibrosis. Can. J. Diabetes 40, 389–392.

[1] Les publications issues d’une collaboration inter-services sont répertoriées dans chacun des services impliqués.

[2] La liste des auteurs a parfois été raccourcie par […] ou et al. par soucis d’espace.