Geriatrie

Voici la liste des publications récentes des professeurs du service de gériatrie du Département de médecine. Les cliniciens et les professeurs-chercheurs avec octrois de ce service sont en caractères gras. Les professeurs associés sont en caractères italiques. 

Dernière mise à jour : 11 jan 2021

2019

1.      Al-enezi, M.S., Abdo, R.-A., Mokeddem, M.Y., Slimani, F.A.A., Khalil, A., Fülöp T., Turcotte, E., Bentourkia, M., 2019. Assessment of artery calcification in atherosclerosis with dynamic 18F-FDG-PET/CT imaging in elderly subjects. International Journal of Cardiovascular Imaging. https://doi.org/10.1007/s10554-019-01527-7

2.      Arguin G, Bourzac JF, Placet M, Molle CM, Paquette M, Beaudoin JF, Rousseau JA, Lecomte R, Plourde M, Gendron FP.2019 The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Sci Rep. 2017 Oct 10;7(1):12917. https://doi.org/10.1038/s41598-017-13300-8.

3.      Boukabous, Inès, Alexis Marcotte-Chénard, Taha Amamou, Pierre Boulay, Martin Brochu, Tessier D, Isabelle Dionne, et Eléonor Riesco. « Low-Volume High-Intensity Interval Training (HIIT) versus Moderate-Intensity Continuous Training on Body Composition, Cardiometabolic Profile and Physical Capacity in Older Women ». Journal of Aging and Physical Activity, 29 avril 2019, 1‑34. https://doi.org/10.1123/japa.2018-0309.

4.      Castellano, Christian-Alexandre, Carol Hudon, Etienne Croteau, Melanie Fortier, Valerie St-Pierre, Camille Vandenberghe, Scott Nugent, Fülöp T, Cunnane S et al. 2019. « Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up. » Frontiers in Aging Neuroscience 11: 15. https://doi.org/10.3389/fnagi.2019.00015.

5.      Chappus-McCendie H, Chevalier L, Roberge C, Plourde M. Omega-3 PUFA metabolism and brain modifications during aging. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109662. https:// doi.org/10.1016/j.pnpbp.2019.109662 

6.      Cohen, Alan A., Mélanie Levasseur, Parminder Raina, Linda P. Fried, et Fülöp T. « Is Aging Biology Ageist? » The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 1 octobre 2019. https://doi.org/10.1093/gerona/glz190.

7.      Cossette, B., Taseen, R., Roy-Petit, J., Villemure, M.-P., Grondin, M., Ricard, G., Goyer, F., Blanchard, C., Joly-Mischlich, T.,Éthier, J.-F., 2019. A pharmacist-physician intervention model using a computerized alert system to reduce high-risk medication use in primary care. European Journal of Clinical Pharmacology. https://doi.org/10.1007/s00228-019-02660-x

8.      Fortier, M, Castellano CA,  Croteau E, Langlois F,  Bocti, C, St-Pierre V, Vandenberghe C, Cunnane S T, Fülöp T et al. 2019. « A Ketogenic Drink Improves Brain Energy and Some Measures of Cognition in Mild Cognitive Impairment ». Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, février. https://doi.org/10.1016/j.jalz.2018.12.017.

9.      Fülöp T., Witkowski, J.M., Larbi, A., Khalil, A., Herbein, G., Frost, E.H., 2019. Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer’s disease? Journal of NeuroVirology. https://doi.org/10.1007/s13365-019-00732-3    

10.  Fülöp T, Larbi A, et Jacek M. Witkowski. « Human Inflammaging. » Gerontology, 3 mai 2019, 1‑10. https://doi.org/10.1159/000497375.

11.  Fülöp T, Larbi A,  A. Khalil, Alan A. Cohen, et Jacek M. Witkowski. « Are We Ill Because We Age? » Frontiers in Physiology 10 (2019): 1508. https://doi.org/10.3389/fphys.2019.01508.

12.  Haddad, M, Perrotte M,  Landri S, Lepage A, Fülöp T, et Ramassamy C. 2019. « Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease ». Journal of Alzheimer’s Disease: JAD 69 (3): 751‑62. https://doi.org/10.3233/JAD-181272.

13.  Haddad MPerrotte MKhedher MRBDemongin C, Lepage AFülöp T, Ramassamy C 2019 « Methylglyoxal and Glyoxal as Potential Peripheral Markers for MCI Diagnosis and Their Effects on the Expression of Neurotrophic, Inflammatory and Neurodegenerative Factors in Neurons and in Neuronal Derived-Extracellular Vesicles. Int J Mol Sci 3;20 (19) https://doi.org/10.3390/ijms20194906.

14.  Larbi, A., 2019. Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence. EBioMedicine 39, 44–58. https://doi.org/10.1016/j.ebiom.2018.11.053

15.  Le Page, A., A. Khalil, P. Vermette, E.H. Frost, A. Larbi, J.M. Witkowski, et Fülöp T. « The role of elastin-derived peptides in human physiology and diseases ». Matrix Biology, 2019. https://doi.org/10.1016/j.matbio.2019.07.004.

16.  Lu, Y., Karagounis, L.G., Ng, T.P., Carre, C., Narang, V., Wong, G., Ying Tan, C.T., Zin Nyunt, M.S., Gao, Q., Abel, B., Poidinger, M., Fulop, T., Bosco, N., Larbi, A., 2019. Systemic and Metabolic Signature of Sarcopenia in Community-Dwelling Older Adults. J. Gerontol. A Biol. Sci. Med. Sci. https://doi.org/10.1093/gerona/glz001

17.  Lu, Y., Monaco, G., Camous, X., Andiappan, A.K., Rotzschke, O., Ng, T.P., Larbi, A., 2019. Biomarker Signatures Predicting 10-Year All-Cause and Disease-Specific Mortality. Journals of Gerontology - Series A Biological Sciences and Medical Sciences 74, 469–479. https://doi.org/10.1093/gerona/gly138

18.  Lu, Y., M. Niti, K.B. Yap, C.T.Y. Tan, M.S. Zin Nyunt, L. Feng, B.Y. Tan, Larbi, A et al. « Assessment of Sarcopenia Among Community-Dwelling At-Risk Frail Adults Aged 65 Years and Older Who Received Multidomain Lifestyle Interventions: A Secondary Analysis of a Randomized Clinical Trial ». JAMA network open 2, no 10 (2019): e1913346. https://doi.org/10.1001/jamanetworkopen.2019.13346.

19.  Maréchal, R., Fontvieille, A., Parent-Roberge, H., Fülöp T., Riesco, E., Pavic, M., Dionne,I.J., 2019. Effect of a mixed-exercise program on physical capacity and sedentary behavior in older adults during cancer treatments. https://doi.org/10.1007/s40520-018-1097-4

20.  Monaco, G., Lee, B., Xu, W., Mustafah, S., Hwang, Y.Y., Carré, C., Burdin, N., Visan, L., Ceccarelli, M., Poidinger, M., Zippelius, A., Pedro de Magalhães, J., Larbi, A., 2019. RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types. https://doi.org/10.1016/j.celrep.2019.01.041

21.  Muscedere, J., P.M. Kim, J. Afilalo, C. Balion, V.E. Baracos, D. Bowdish, M. Cesari, Fülöp T et al. « Proceedings of the Canadian Frailty Network Workshop: Identifying Biomarkers of Frailty to Support Frailty Risk Assessment, Diagnosis and Prognosis. Toronto, January 15, 2018 ». The Journal of frailty & aging 8, no 3 (2019): 106‑16. https://doi.org/10.14283/jfa.2019.12.

22.  Nolze-Charron, Geneviève, Raphaël Dufort-Rouleau, Jean-Christophe Houde, Matthieu Dumont, Christian-Alexandre Castellano, Cunnane S-C , Dominique Lorrain, Fülöp T, Maxime Descoteaux, et Bocti C. « Tractography of the External Capsule and Cognition: A Diffusion MRI Study of Cholinergic Fibers ». Experimental Gerontology 130 (février 2020): 110792. https://doi.org/10.1016/j.exger.2019.110792.

23.  Perrotte MLe Page AFournet MLe Sayec MRassart ÉFülöp TRamassamy C« Blood-based redox-signature and their association to the cognitive scores in MCI and Alzheimer’s disease patients. Free Radic Biol Med. 2019 Jan;130:499-511. . https:// doi.org/10.1016/j.freeradbiomed

24.  Puts, M., T. Hsu, E. Szumacher, D. Dawe, M. Fitch, J. Jones, Fülöp T  S. Alibhai, F. Strohschein, et Network on Aging and Cancer Canadian. « Never too old to learn new tricks: Surveying Canadian health care professionals about learning needs in caring for older adults with cancer ». Current Oncology 26, no 2 (2019): 71‑72. https://doi.org/10.3747/co.26.4833.

25.  Sedighi, S.M., Prud’Homme, P., Ghachem, A., Lepage, S., Nguyen, M., Fülöp T., Khalil, A., 2019. Increased level of high-sensitivity cardiac Troponin T in a geriatric population is determined by comorbidities compared to age. IJC Heart and Vasculature. https://doi.org/10.1016/j.ijcha.2019.02.015¸

26.  Strickland, M., B. Yacoubi-Loueslati, B. Bouhaouala-Zahar, S.L.F. Pender, et Larbi A. 2019. « Relationships between ion channels, mitochondrial functions and inflammation in human aging ». Frontiers in Physiology 10 (MAR). https://doi.org/10.3389/fphys.2019.00158.

27.  Tizazu, A.M., M.S. Zin Nyunt, O. Cexus, K. Suku, E. Mok, C.H. Xian, J. Chong, Fülöp T Larbi A. et al. « Metformin monotherapy downregulates diabetes-associated inflammatory status and impacts on mortality ». Frontiers in Physiology 10, no MAY (2019). https://doi.org/10.3389/fphys.2019.00572.

28.  Valenzuela, Jesus Felix Bayta, Christopher Monterola, Victor Joo Chuan Tong, Fülöp T , Tze Pin Ng, et Larbi A. « Degree and Centrality-Based Approaches in Network-Based Variable Selection: Insights from the Singapore Longitudinal Aging Study ». PloS One 14, no 7 (2019): e0219186. https://doi.org/10.1371/journal.pone.0219186.

29.  Witkowski, Jacek M., Ewa Bryl, et Fülöp T. « Should We Try to Alleviate Immunosenescence and Inflammaging - Why, How and to What Extent? » Current Pharmaceutical Design 25, no 39 (2019): 4154‑62. https://doi.org/10.2174/1381612825666191111153016.

30.  Xu, W., Monaco, G., Wong, E.H., Tan, W.L.W., Kared, H., Simoni, Y., Tan, S.W., How, W.Z.Y., Tan, C.T.Y., Lee, B.T.K., Carbajo, D., Srinivasan, K.G., Low, I.C.H., Mok, E.W.H., Foo, S., Lum, J., Tey, H.L., Tan, W.P., Poidinger, M., Newell, E., Ng, T.P., Foo, R., Akbar, A.N., Fülöp, T.,

31.   Zhong XLu YGao QNyunt MSZFülöp TMonterola CPTong JCLarbi A Ng TP., 2019 Estimating Biological Age in the Singapore Longitudinal Aging Study. J Gerontol A Biol Sci Med Sci. 2019 Jun 8. pii: glz146. doi: 10.1093/gerona/glz146  

2018

  • Al-Enezi, M.S., Slimani, F.A.A., Khalil, A., Fulop, T., Bentourkia, M., 2018. Modeling and Correlation between CT Calcification and Glucose Metabolism in Atherosclerosis. Presented at the 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings. https://doi.org/10.1109/NSSMIC.2017.8532841
  • Brenna, J. Thomas, Mélanie Plourde, Ken D. Stark, Peter J. Jones, et Yu-Hong Lin. « Best Practices for the Design, Laboratory Analysis, and Reporting of Trials Involving Fatty Acids ». The American Journal of Clinical Nutrition, 21 juin 2018. https://doi.org/10.1093/ajcn/nqy089.
  • Conroy, T., Hammel, P., Hebbar, M., Ben Abdelghani, M., Wei, A.C., Raoul, J.-L., Choné, L., Francois, E., Artru, P., Biagi, J.J., Lecomte, T., Assenat, E., Faroux, R., Ychou, M., Volet, J., Sauvanet, A., Breysacher, G., Di Fiore, F., Cripps, C., Kavan, P., Texereau, P., Bouhier-Leporrier, K., Khemissa-Akouz, F., Legoux, J.-L., Juzyna, B., Gourgou, S., O’Callaghan, C.J., Jouffroy-Zeller, C., Rat, P., Malka, D., Castan, F., Bachet, J.-B., Lemay F, Canadian Cancer Trials Group and the Unicancer-GI–PRODIGE Group, 2018. FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. N. Engl. J. Med. 379, 2395–2406. https://doi.org/10.1056/NEJMoa1809775
  • Coulombe K, Kerdiles O, Tremblay C, Emond V, Lebel M, Boulianne AS, Plourde M, Cicchetti F, Calon F. «Impact of DHA intake in a mouse model of synucleinopathy » Exp Neurol. 2018 Mar; 301, 39-49.https://doi.org/10.1016/j.expneurol.2017.12.002 
  • Croteau, Etienne, Christian-Alexandre Castellano, Marie Anne Richard, Mélanie Fortier, Scott Nugent, Martin Lepage, Simon Duchesne,  Christian Bocti, Tamas Fulop, Stephen C Cunnane. « Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease ». Journal of Alzheimer’s Disease: JAD 64, no 2 (2018): 551‑61. https://doi.org/10.3233/JAD-180202.
  • Fulop, Tamas, Anis Larbi« Biology of aging: Paving the way for healthy aging. - PubMed - NCBI ». Consulté le 5 avril 2018. https://www.ncbi.nlm.nih.gov/pubmed/29550563.
  • Fulop, Tamas. « In Memoriam Ladislas Robert (1924-2018) ». Biogerontology 19, no 3‑4 (juillet 2018): 185‑87. https://doi.org/10.1007/s10522-018-9760-x.
  • Fulop, Tamas, Jacek M. Witkowski, Karine Bourgade, Abdelouahed Khalil, Echarki Zerif, Anis Larbi, Katsuiku Hirokawa, Bocti Christian, Lacombe Guy et al. « Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease? » Frontiers in Aging Neuroscience 10 (2018): 224. https://doi.org/10.3389/fnagi.2018.00224.
  • Fulop, Tamas, Jacek M. Witkowski, Fabiola Olivieri, et Anis Larbi. « The Integration of Inflammaging in Age-Related Diseases ». Seminars in Immunology, 1 octobre 2018. https://doi.org/10.1016/j.smim.2018.09.003.
  • Fülöp, T., R.F. Itzhaki, B.J. Balin, J. Miklossy, et A.E. Barron. « Role of microbes in the development of Alzheimer’s disease: State of the Art - An International Symposium Presented at the 2017 IAGG Congress in San Francisco ». Frontiers in Genetics 9, no SEP (2018). https://doi.org/10.3389/fgene.2018.00362.
  • Imbeault, Hélène, Lise Gagnon, Hélène Pigot, Sylvain Giroux, Nicolas Marcotte, Perrine Cribier-Delande, Julie Duval, Fulop Tamas et Guy Lacombe al. « Impact of AP@LZ in the Daily Life of Three Persons with Alzheimer’s Disease: Long-Term Use and Further Exploration of Its Effectiveness ». Neuropsychological Rehabilitation 28, no 5 (juillet 2018): 755‑78. https://doi.org/10.1080/09602011.2016.1172491.
  • Le Page, Aurélie, Gilles Dupuis, Anis Larbi, Jacek M. Witkowski, et Tamas Fülöp. « Signal Transduction Changes in CD4+ and CD8+ T Cell Subpopulations with Aging ». Experimental Gerontology, 5 janvier 2018. https://doi.org/10.1016/j.exger.2018.01.005.
  • Léveillé-, Pauline, Mathieu Hamel, Jean-Luc Ardilouze, Jean-Charles Pasquier, Charles Deacon, Kevin Whittingstall, et Mélanie Plourde. « Pilot Study of EEG in Neonates Born to Mothers with Gestational Diabetes Mellitus ». International Journal of Developmental Neuroscience: The Official Journal of the International Society for Developmental Neuroscience, 19 janvier 2018. https://doi.org/10.1016/j.ijdevneu.2018.01.003.
  • Léveillé, Pauline, Clémence Rouxel, et Mélanie Plourde. « Diabetic Pregnancy, Maternal and Fetal Docosahexaenoic Acid: A Review of Existing Evidence ». The Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 31, no 10 (mai 2018): 1358‑63. https://doi.org/10.1080/14767058.2017.1314460.
  • Lu, Y., H. Kared, S.W. Tan, E. Becht, E.W. Newell, Bever Van, T.P. Ng, et A. Larbi. « Dynamics of helper CD4 T cells during acute and stable allergic asthma ». Article in Press, 2018. Scopus. https://doi.org/10.1038/s41385-018-0057-9.
  • Meneilly, G.S., A. Knip, D.B. Miller, D. Sherifali, D. Tessier, A. Zahedi, et Diabetes Canada Clinical Practice Guidelines Expert Committee. « Diabetes in Older People ». Canadian Journal of Diabetes 42 (2018): S283‑95. https://doi.org/10.1016/j.jcjd.2017.10.021.
  • Perrotte, M., Le Page, A., Fournet, M., Le Sayec, M., Rassart, É., Fulop, T., Ramassamy, C., 2018. Blood-based redox-signature and their association to the cognitive scores in MCI and Alzheimer’s disease patients. Free Radic. Biol. Med. 130, 499–511. https://doi.org/10.1016/j.freeradbiomed.2018.10.452

2017

Arguin, G., Bourzac, J.-F., Placet, M., Molle, C.M., Paquette, M., Beaudoin, J.-F., Rousseau, J.A., Lecomte, R., Plourde, M., Gendron, F.-P., (2017). The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Sci. Rep. 7(1):12917. URL: www.ncbi.nlm.nih.gov/pubmed/29018292

Bergeron, D., Flynn, K., Verret, L., Poulin, S., Bouchard, R.W., Bocti, C., Fülöp, T., Lacombe, G., Gauthier, S., Nasreddine, Z., Laforce, R.J., 2017. Multicenter Validation of an MMSE-MoCA Conversion Table. J. Am. Geriatr. Soc. 65, 1067–1072. 

Bocti, C., Pépin, F., Tétreault, M., Cossette, P., Langlois, F., Imbeault, H., Duval, N., Lacombe, G., Fulop, T., (2017). Orthostatic hypotension associated with executive dysfunction in mild cognitive impairment. J. Neurol. Sci. 382:79–83. URL: linkinghub.elsevier.com/retrieve/pii/S0022510X17343186

Bourgade, K., Dupuis, G., Frost, E.H., Fülöp, T., (2017). Anti-viral properties of amyloid-β peptides, dans: Handbook of Infection and Alzheimer’s Disease. IOS Press, p. 221‑240 

Camponova, P., Le Page, A., Berrougui, H., Lamoureux, J., Pawelec, G., Witkowski, M.J., Fulop, T., Khalil, A., (2017). Alteration of high-density lipoprotein functionality in Alzheimer’s disease patients. Can. J. Physiol. Pharmacol. 95(8):894–903. URL: www.ncbi.nlm.nih.gov/pubmed/28384414

Castellano, C.-A., Paquet, N., Dionne, I.J., Imbeault, H., Langlois, F., Croteau, E., Tremblay, S., Fortier, M., Matte, J.J., Lacombe, G., Fülöp, T., Bocti, C., Cunnane, S.C., 2017. A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer’s Disease: Preliminary Results from a Neuroimaging Study. J. Alzheimers. Dis. 56, 1459–1468. 

Chan, H.Y., Ho, R.C.-M., Mahendran, R., Ng, K.S., Tam, W.W.-S., Rawtaer, I., Tan, C.H., Larbi, A., Feng, L., Sia, A., Ng, M.K.-W., Gan, G.L., Kua, E.H., (2017). Effects of horticultural therapy on elderly’ health: protocol of a randomized controlled trial. BMC Geriatr. 17(1):192. URL: www.ncbi.nlm.nih.gov/pubmed/28851276

Chouinard-Watkins, R., Vandal, M., Léveillé, P., Pinçon, A., Calon, F.,Plourde, M., 2017. Docosahexaenoic acid prevents cognitive deficits in human apolipoprotein E epsilon 4-targeted replacement mice. Neurobiol. Aging 57, 28–35. 

Cohen, A.A., Legault, V., Fuellen, G., Fülöp, T., Fried, L.P., Ferrucci, L., 2017. EPUB - The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations. Exp. Gerontol. 

Cossette, B., Éthier, J.-F., Joly-Mischlich, T., Bergeron, J., Ricard, G., Brazeau, S., Caron, M., Germain, O., Payette, H., Kaczorowski, J., Levine, M., (2017). Reduction in targeted potentially inappropriate medication use in elderly inpatients: a pragmatic randomized controlled trial. Eur. J. Clin. Pharmacol. 73(10):1237–1245. URL: www.ncbi.nlm.nih.gov/pubmed/28717929

Couchie, D., Vaisman, B., Abderrazak, A., Mahmood, D.F.D., Hamza, M.M., Canesi, F., Diderot, V., El Hadri, K., Nègre-Salvayre, A., Le Page, A., Fulop, T., Remaley, A.T., Rouis, M., 2017. Human Plasma Thioredoxin-80 Increases With Age and in ApoE(-/-) Mice Induces Inflammation, Angiogenesis, and Atherosclerosis. Circulation 136, 464–475. 

Croteau, E., Castellano, C.A., Fortier, M., Bocti, C., Fulop, T., Paquet, N., Cunnane, S.C., 2017. EPUB - A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer’s disease. Exp. Gerontol. 

Dubiel, E.A., Fülöp, T., Vigier, S., Vermette, P., (2017). Quartz crystal microbalance as an assay to detect anti-drug antibodies for the immunogenicity assessment of therapeutic biologics. Anal. Bioanal. Chem. 409(30):7153–7167. URL: www.ncbi.nlm.nih.gov/pubmed/29026983

Fulop, T., Witkowski, J.M.M., Le Page, A., Fortin, C., Pawelec, G., Larbi, A., 2017. Intracellular signalling pathways: targets to reverse immunosenescence. Clin. Exp. Immunol. 187, 35–43. 

Fülöp, T., Herbein, G., Cossarizza, A., Witkowski, J.M., Frost, E., Dupuis, G., Pawelec, G., Larbi, A., 2017. Cellular Senescence, Immunosenescence and HIV, in: Interdisciplinary Topics in Gerontology and Geriatrics. pp. 28–46. 

Fülöp, T., Nemes, R., Mészáros, T., Urbanics, R., Kok, R.J., Jackman, J.A., Cho, N., Storm, G., Szebeni, J., (2017). EPUB - Complement activation in vitro and reactogenicity of low-molecular weight dextran-coated SPIONs in the pig CARPA model correlation with physicochemical features and clinical information. J. Control. Release URL: www.ncbi.nlm.nih.gov/pubmed/29203414

Haq, K., Fulop, T., Tedder, G., Gentleman, B., Garneau, H., Meneilly, G.S., Kleppinger, A., Pawelec, G., McElhaney, J.E., (2017). Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status. J. Gerontol. A. Biol. Sci. Med. Sci. 72(9):1163–1170. URL: http://www.ncbi.nlm.nih.gov/pubmed/27789617

Ikhlef, S., Berrougui, H., Kamtchueng Simo, O., Zerif, E., Khalil, A., 2017. Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport. PLoS One 12, e0173385. 

Itzhaki, R.F., Lathe, R., Balin, B.J., Ball, M.J., Bearere, E.L., Braak, H., Bullido, M.J., Carter, C., Cleric, M., Cosby, S.L., Del Tredici, K., Field, H., Fulop, T., et al., (2017). Microbes and Alzheimer’s disease, dans: Handbook of Infection and Alzheimer’s Disease. IOS Press, p. 3‑8 

Johnstone, J., Parsons, R., Botelho, F., Millar, J., McNeil, S., Fulop, T., McElhaney, J.E., Andrew, M.K., Walter, S.D., Devereaux, P.J., Malek, M., Brinkman, R.R., Bramson, J., Loeb, M., 2017. T-Cell Phenotypes Predictive of Frailty and Mortality in Elderly Nursing Home Residents. J. Am. Geriatr. Soc. 65, 153–159. 

Kamtchueng Simo, O., Ikhlef, S., Berrougui, H., Khalil, A., (2017). Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages. Can. J. Physiol. Pharmacol. 95(8):977–984. URL: www.ncbi.nlm.nih.gov/pubmed/28704619

Khalil, A., Kamtchueng Simo, O., Ikhlef, S., Berrougui, H., (2017). The role of paraoxonase 1 in regulating high-density lipoprotein functionality during aging. Can. J. Physiol. Pharmacol. 95(10):1254–1262. URL: www.ncbi.nlm.nih.gov/pubmed/28746818

Le Page, A., Garneau, H., Dupuis, G., Frost, E.H., Larbi, A., Witkowski, J.M., Pawelec, G., Fülöp, T., (2017). Differential Phenotypes of Myeloid-Derived Suppressor and T Regulatory Cells and Cytokine Levels in Amnestic Mild Cognitive Impairment Subjects Compared to Mild Alzheimer Diseased Patients. Front. Immunol. 8:783. URL: www.ncbi.nlm.nih.gov/pubmed/28736551

Le Page, A., Lamoureux, J., Bourgade, K., Frost, E.H., Pawelec, G., Witkowski, J.M., Larbi, A., Dupuis, G., Fülöp, T., (2017). Polymorphonuclear Neutrophil Functions are Differentially Altered in Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease Patients. J. Alzheimers. Dis. 60(1):23–42. URL: http://www.ncbi.nlm.nih.gov/pubmed/28777750

Léveillé, P., Chouinard-Watkins, R., Windust, A., Lawrence, P., Cunnane, S.C., Brenna, J.T., Plourde, M., 2017. Metabolism of uniformly labeled (13)C-eicosapentaenoic acid and (13)C-arachidonic acid in young and old men. Am. J. Clin. Nutr. 106, 467–474. 

Léveillé, P., Rouxel, C., Plourde, M., 2017. EPUB - Diabetic pregnancy, maternal and fetal docosahexaenoic acid: a review of existing evidence. J. Matern. Fetal. Neonatal Med. 1–6. 

Li, M., Li, Y., Weeks, O., Mijatovic, V., [...], Fulop, T.et al., (2017). SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J. Am. Soc. Nephrol. 28(3):981‑994. URL: www.ncbi.nlm.nih.gov/pubmed/27920155

Ma, D.W.L., Bertolo, R.F., Robbins, S., Marchand, V., Duncan, A.M., Plourde, M., Grantham, A., 2017. Discussion of The Impact of CIHR Reforms on the Funding of Nutritional Sciences in Canada. Appl. Physiol. Nutr. Metab. 42, 86–87. 

Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V.D., Debonneuil, E., Dobrovolskaya, E., Fedichev, P., Fedintsev, A., Fraifeld, V., Franceschi, C., Freer, R., Fülöp, T., et al., 2017. A review of the biomedical innovations for healthy longevity. Aging (Albany. NY). 9, 7–25. 

Nock, T.G., Chouinard-Watkins, R., Plourde, M., (2017). Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline. Biochim. Biophys. Acta 1862(10 Pt A):1068‑1078. URL: http://www.ncbi.nlm.nih.gov/pubmed/28733268

Pannérec, A., Migliavacca, E., De Castro, A., Michaud, J., Karaz, S., Goulet, L., Rezzi, S., Ng, T.P., Bosco, N., Larbi, A., Feige, J.N., (2017). EPUB - Vitamin B12 deficiency and impaired expression of amnionless during aging. J. Cachexia. Sarcopenia Muscle URL: www.ncbi.nlm.nih.gov/pubmed/29159972

Takata, K., Kozaki, T., Lee, C.Z.W., Thion, M.S., Otsuka, M., Lim, S., [...],Larbi, A., et al. (2017). Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function. Immunity 47(1):183–198.e6. URL: http://www.ncbi.nlm.nih.gov/pubmed/28723550

Valenzuela, J.F., Monterola, C., Tong, V.J.C., Ng, T.P., Larbi, A., (2017). Health and disease phenotyping in old age using a cluster network analysis. Sci. Rep. 7(1):15608. URL: www.nature.com/articles/s41598-017-15753-3

Witkowski, J.M., Mikosik, A., Bryl, E., Fulop, T., (2017). EPUB - Proteodynamics in aging human T cells – The need for its comprehensive study to understand the fine regulation of T lymphocyte functions. Exp. Gerontol. URL: www.ncbi.nlm.nih.gov/pubmed/29038026

Xu, W., Larbi, A., (2017). Markers of T Cell Senescence in Humans. Int. J. Mol. Sci. 18(8)URL: www.ncbi.nlm.nih.gov/pubmed/28796199

[1] Les publications issues d’une collaboration inter-services sont répertoriées dans chacun des services impliqués.

[2] La liste des auteurs a parfois été raccourcie par […] ou et al. par soucis d’espace.

2016

Baëhl, S., Garneau, H., Lorrain, D., Viens, I., Svotelis, A., Lord, J.M., Cabana, F., Larbi, A., Dupuis, G., Fülöp, T., 2016. Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study. Gerontology 62, 477–490.             

Bourgade, K., Dupuis, G., Frost, E.H., Fülöp, T., 2016. Anti-Viral Properties of Amyloid-β Peptides. J. Alzheimer’s Dis. 54, 859–878.               

Bourgade, K., Le Page, A., Bocti, C., Witkowski, J.M., Dupuis, G., Frost, E.H., Fülöp, T., 2016. Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model. J. Alzheimer’s Dis. 50, 1227–1241.   

Bron, D., Soubeyran, P., Fulop, T., 2016. Innovative approach to older patients with malignant hemopathies. Haematologica.      

Chouinard-Watkins, R., Pincon, A., Coulombe, J.-D., Spencer, R., Massenavette, L., Plourde, M., 2016. A Diet Rich in Docosahexaenoic Acid Restores Liver Arachidonic Acid and Docosahexaenoic Acid Concentrations in Mice Homozygous for the Human Apolipoprotein E 4 Allele. J. Nutr. 146, 1315–1321. 

Cossette, B., Bergeron, J., Ricard, G., Éthier, J.-F., Joly-Mischlich, T., Levine, M., Sene, M., Mallet, L., Lanthier, L., Payette, H., Rodrigue, M.-C., Brazeau, S., 2016. Knowledge Translation Strategy to Reduce the Use of Potentially Inappropriate Medications in Hospitalized Elderly Adults. J. Am. Geriatr. Soc. 64, 2487–2494.

Cunnane, S.C., Courchesne-Loyer, A., Vandenberghe, C., St-Pierre, V., Fortier, M., Hennebelle, M., Croteau, E., Bocti, C., Fulop, T., Castellano, C.-A., 2016. Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease. Front. Mol. Neurosci. 9, 53.            

Goldeck, D., Witkowski, J.M., Fulop, T., 2016. Peripheral immune signatures in alzheimer disease. Curr. Alzheimer Res, 13, 739-749.                       

Desnoyers, A., Riesco, E., Fulop, T., Pavic, M., 2016. [Physical activity and cancer: Update and literature review]. La Rev. Med. interne 37, 399–405.        

Fulop, T., Dupuis, G., Baehl, S., Le Page, A., Bourgade, K., Frost, E., Witkowski, J.M., Pawelec, G., Larbi, A., Cunnane, S., 2016. From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation. Biogerontology.      

Fulop, T., 2016. Biological research into aging: from cells to clinic. Biogerontology 17, 1–6.   

Fülöp, T., Dupuis, G., Witkowski, J.M., Larbi, A., 2016. The Role of Immunosenescence in the Development of Age-Related Diseases. Rev. Invest. Clin. 68, 84–91.           

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Rink, L., Mariani, E., Fulop, T., Dedoussis, G., Herbein, G., Provinciali, M., Jajte, J., Lengyel, I., Mocchegiani, E., Malavolta, M., 2016. Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study. Eur. J. Nutr. 1–10.

Haq, K., Fulop, T., Tedder, G., Gentleman, B., Garneau, H., Meneilly, G.S., Kleppinger, A., Pawelec, G., McElhaney, J.E., 2016. Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status. J. Gerontol. A. Biol. Sci. Med. Sci.

Hennebelle, M., Courchesne-Loyer, A., St-Pierre, V., Vandenberghe, C., Castellano, C.-A., Fortier, M., Tessier, D., Cunnane, S.C., 2016. Preliminary evaluation of a differential effect of an α-linolenate-rich supplement on ketogenesis and plasma ω-3 fatty acids in young and older adults. Nutrition 32, 1211–1216.             

Ikhlef, S., Berrougui, H., Kamtchueng Simo, O., Khalil, A., 2016. Paraoxonase 1-treated oxLDL promotes cholesterol efflux from macrophages by stimulating the PPARγ-LXRα-ABCA1 pathway. FEBS Lett. 590, 1614–1629.    

Imbeault, H., Gagnon, L., Pigot, H., Giroux, S., Marcotte, N., Cribier-Delande, P., Duval, J., Bocti, C., Lacombe, G., Fülöp, T., Bier, N., 2016. Impact of AP@LZ in the daily life of three persons with Alzheimer’s disease: long-term use and further exploration of its effectiveness. Neuropsychol. Rehabil. 1–24.             

Itzhaki, R.F., […], Fulop, T., Grassi, C., Griffin, W.S.T., Haas, J., et al., 2016. Microbes and Alzheimer’s Disease. J. Alzheimer’s Dis. 51, 979–984.      

Kumar, A., Abbas, W., Colin, L., Khan, K.A., Bouchat, S., Varin, A., Larbi, A., Gatot, J.-S., Kabeya, K., Vanhulle, C., Delacourt, N., Pasquereau, S., Coquard, L., Borch, A., König, R., Clumeck, N., De Wit, S., Rohr, O., Rouzioux, C., Fulop, T., Van Lint, C., Herbein, G., 2016. Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line. Sci. Rep. 6, 24090.        

Léveillé, P., Ardilouze, J.-L., Pasquier, J.-C., Deacon, C., Whittingstall, K., Plourde, M., 2016. Fatty acid profile in cord blood of neonates born to optimally controlled gestational diabetes mellitus. Prostaglandins, Leukot. Essent. Fat. Acids 115, 48–52.         

Lu, Y., Tan, C.T.Y., Nyunt, M.S.Z., Mok, E.W.H., Camous, X., Kared, H., Fulop, T., Feng, L., Ng, T.P., Larbi, A., 2016. Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies. Oncotarget 7, 28783–95.      

Matta, J., Mayo, N., Dionne, I.J., Gaudreau, P., Fulop, T., Tessier, D., Gray-Donald, K., Shatenstein, B., Morais, J.A., 2016. Muscle mass index and animal source of dietary protein are positively associated with insulin resistance in participants of the NuAge study. J. Nutr. Heal. Aging 20, 90–97.         

Matta, J., Mayo, N., Dionne, I.J., Gaudreau, P., Fülöp, T., Tessier, D., Gray-Donald, Ka., Shatenstein, B., Scott, S.C., Morais, J.A., 2016. Determining the Development of Insulin Resistance in Older Adults of the NuAge cohort Using Trajectory Modeling of the Homeostatic Model Assessment of Insulin Resistance Score. J. Diabetes Obes. 3, 1–8. 

Meneilly, G.S., Sherifali, D., Tessier, D., 2016. Diabetes in Older Adults: Starting a National Dialogue. Can. J. Diabetes 40, 1.           

Meneilly, G.S., Tessier, D.M., 2016. Diabetes, Dementia and Hypoglycemia. Can. J. Diabetes 40, 73–76. 

Mikosik, A., Jasiulewicz, A., Daca, A., Henc, I., Frąckowiak, J.E., Ruckemann-Dziurdzińska, K., Foerster, J., Page, A. Le, Bryl, E., Fulop, T., Witkowski, J.M., 2016. Roles of calpain-calpastatin system (CCS) in human T cell activation. Oncotarget 7.    

Nugent, S., Castellano, C.A., Bocti, C., Dionne, I., Fulop, T., Cunnane, S.C., 2016. Relationship of metabolic and endocrine parameters to brain glucose metabolism in older adults: do cognitively-normal older adults have a particular metabolic phenotype? Biogerontology 17, 241–55.          

Pinçon, A., Coulombe, J.-D., Chouinard-Watkins, R., Plourde, M., 2016. Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. J. Nutr. Biochem. 34, 83–88.

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., Cossarizza, A., 2016. Aging of the immune system: Focus on inflammation and vaccination. Eur. J. Immunol. 46, 2286–2301.

Tessier, D.M., Meneilly, G.S., Moleski, L., Trottier, L., Lanthier, L., 2016. Influence of Blood Pressure and Other Clinical Variables on Long-Term Mortality in a Cohort of Elderly Subjects with Type 2 Diabetes. Can. J. Diabetes 40, 12–16.            

[1] Les publications issues d’une collaboration inter-services sont répertoriées dans chacun des services impliqués.

[2] La liste des auteurs a parfois été raccourcie par […] ou et al. par soucis d’espace.