Pre Mélanie Plourde, Ph. D.
Professeure agrégée

Chercheure-boursière - Junior 2, FRSQ

Titulaire de la  Chaire CRMUS sur le métabolisme des lipides lors du vieillissement
Membre de  l'axe de recherche « Clinique » du Centre de recherche sur le vieillissement du CSSS-IUGS, et du  thème porteur « Vieillissement »  de la Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke.
Service de gériatrie
Département de médecine
Faculté de médecine et des sciences de la santé
Université de Sherbrooke
CSSS-IUGS, Pavillon D'Youville
1036, rue Belvédère Sud
Sherbrooke (Québec) J1H 4C4

Téléphone :  819 780-2220, poste 45664
Télécopieur : 819 829-7141

Courriel : Melanie.Plourde2@USherbrooke.ca
Études postdoctorales
  • 07/2006-08/2009
    Lipide, nutrition et métabolisme
    Centre de recherche sur le vieillissement
    CSSS-IUGS
    Superviseur : Pr Stephen C. Cunnane
    Université de Sherbrooke
  • 08/2009-07/2010
    Nutrition et génétique
    Superviseurs : Pre Marie-Claude Vohl et Pr Louis Pérusse
    Université Laval
Études doctorales
  • 01/2003-04/2006
    Ph. D. en Sciences de la santé - Nutrition
    Université de Bourgogne, France
Maîtrise
  • 05/2001-06/2003
    Technologie et sciences de l'alimentation
    Directeur de maîtrise : Pr Khaled Belkacemi
    Université Laval
Thème porteur de recherche

Vieillissement

Axe de recherche

Clinique du CDRV CSSS-IUGS

Subventions de recherche en cours

Towards investigating apolipoprotein E genotypes on the metabolism of long chain fatty acids.

Chercheuse principale :  Mélanie Plourde

Organisme subventionnaire :
CRSNG
04/2012-04/2017

Causal Relationship Between a LC-Omega-3-Enriched Diet and Cognition.

Chercheuse principale :  Mélanie Plourde
Co-chercheurs : Calon F, Lorrain D

Organisme subventionnaire :
IRSC/CIHR - Subvention de fonctionnement
04/2012-03/2017

Évaluer si les fonctions physiologiques et cognitives dépendent du métabolisme des acides gras.

Chercheuse principale :  Mélanie Plourde

Organisme subventionnaire :
FRQ-S - Établissement de jeunes chercheurs - Junior 1
10/2012-10/2015

Les fonctions du cerveau dépendent-elles des niveaux d’acides gras libres oméga-3 reçus au cours de la vie intra-utérine?

Chercheuse principale :  Mélanie Plourde
Co-chercheurs : Léonard G, Pasquier JC, Ardilouze JL, Whittingstall K

Organisme subventionnaire :
Centre de neurosciences de l'Université de Sherbrooke
PIFIR - Université de Sherbrooke
12/2012-04/2014

Effets d'un régime alimentaire riche en acide gras oméga-3 chez un modèle animal de la maladie de Huntington.

Chercheur principal : Calon F
Co-chercheurs : Plourde M, Samadi P

Organisme subventionnaire :
Projet pilote (INAF)
Institut des nutraceutiques et des aliments fonctionnels.
03/2013-03/2014

Métabolisme d'un acide gras oméga-3 chez les personnes atteintes de la maladie d'Alzheimer à l'aide d'un traceur innovateur - l'acide docosahexaénoïque marqué au carbone-13 (13C-DHA).

Chercheur principal : Cunnane S
Co-chercheurs : Plourde M, Calon F, Vohl MC

Organisme subventionnaire :
Projet pilote (INAF)
Institut des nutraceutiques et des aliments fonctionnels.
03/2013-03/2014

Métabolisme des lipides et risque de diabète de type 2 : étude des individus avec une histoire familiale.

Chercheuse principale :  Riesco E
Co-chercheuses : Plourde M, Dionne I

Organisme subventionnaire :
Initiative stratégique
Centre de recherche sur le vieillissement de l'IUGS
01/2013-03/2014

Les acides gras contenus dans les fibres musculaires affectent la force musculaire et le maintien de la cognition.

Chercheuse principale :  Mélanie Plourde
Co-chercheuse : Aubertin-Leheudre M

Organisme subventionnaire :
Initiative stratégique
Centre de recherche sur le vieillissement de l'IUGS
01/2013-03/2014

Évaluer si le dérèglement du métabolisme des acides gras oméga-3 affecte les fonctions physiologiques et cognitives.

Chercheuse principale :  Mélanie Plourde

Organisme subventionnaire :
Subvention de chercheur en région
Fonds de la recherche du Québec en santé (FRQ - S)
03/2013-09/2013

Supervision d'étudiants - 5 dernières années

(2e, 3e cycles et stagiaires postdoctoraux)
Chouinard-Watkins, Raphael

Programme : Physiologie et biophysique

Diplôme : Ph. D. / En cours

Titre de la recherche : ApoE4 and metabolism of omega-3 fatty acids.

Bourse : N/A

Directrice :  Plourde, Mélanie

Conway, Valérie

Programme :

Diplôme :  Stagiaire postdoctorale / En cours

Titre de la recherche : Étude du dérèglement de l'homéostasie du DHA chez les porteurs de l'apolipoprotéine E4.

Bourse : Département de médecine (2013-2014)

Directrice :  Plourde, Mélanie

Mai Dang, Marie Thuy

Programme : Physiologie et biophysique

Diplôme :  M. Sc. / En cours

Titre de la recherche : Does Incorporation of EPA and DHA in Lipoproteins Differ According to Apolipoprotein E Genotype?

Bourse : N/A

Directrice :  Plourde, Mélanie

Supervision terminée
Chouinard-Watkins, Raphael

Programme : Physiologie et biophysique

Diplôme :  M. Sc. obtenue en 2012

Titre de la recherche : ApoE4 and metabolism of omega-3 fatty acids.

Bourse : N/A

Co-directrice :  Plourde, Mélanie

Focillon, Caroline

Programme : Physiologie et biophysique

Diplôme :  M. Sc. obtenue en 2011

Titre de la recherche : Plasma fatty acid profile in ApoE4 carrier.

Bourse : N/A

Directrice :  Plourde, Mélanie

Publications d'articles (2009-...)

Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2.
Vandal M, Alata W, Tremblay C, Rioux-Perreault C, Salem Jr N, Calon F, Plourde M.
J Neurochem. 2013 Dec 18. doi: 10.1111/jnc.12640. [Epub ahead of print] PMID: 24345162

Safety of dietary conjugated α-linolenic acid (CLNA) in a neonatal pig model.
Castellano CA, Plourde M, Briand SI, Angers P, Giguère A, Matte JJ.Food Chem Toxicol. 2014 Feb;64:119-25. doi: 10.1016/j.fct.2013.11.025. Epub 2013 Nov 28. PMID:24291452

Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline.
Hennebelle M, Plourde M, Chouinard-Watkins R, Castellano CA, Barberger-Gateau P, Cunnane SC.
Proc Nutr Soc. 2013 Oct 9:1-7. [Epub ahead of print] PMID:24103099

Dietary conjugated α-linolenic acid did not improve glucose tolerance in a neonatal pig model.
Castellano CA, Baillargeon JP, Plourde M, Briand SI, Angers P, Giguère A, Matte JJ.
Eur J Nutr. 2013 Sep 5. [Epub ahead of print] PMID: 24005871

Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele.
Chouinard-Watkins R, Rioux-Perreault C, Fortier M, Tremblay-Mercier J, Zhang Y, Lawrence P, Vohl MC, Perron P, Lorrain D, Brenna JT, Cunnane SC, Plourde M.
Br J Nutr. 2013 Nov;110(10):1751-9. doi: 10.1017/S0007114513001268. Epub 2013 Apr 30. No abstract available. PMID: 23631810

A Variant in the LRRFIP1 Gene Is Associated With Adiposity and Inflammation.
Plourde M, Vohl MC, Bellis C, Carless M, Dyer T, Dolley G, Marette A, Després JP, Bouchard C, Blangero J, Pérusse L.
Obesity (Silver Spring). 2012 Jun 28. doi: 10.1038/oby.2012.181. [Epub ahead of print] PMID: 22739583

Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype.
Barberger-Gateau P, Samieri C, Féart C, Plourde M.
Curr Alzheimer Res. 2011 Aug;8(5):479-91. Review.PMID: 21605054

Omega-3 PUFA in Aging.
Plourde M
Lipid Technology, 2011, 23(2), 1-3.  Invited Paper

Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men.
Joseph SV, Jacques H, Plourde M, Mitchell PL, McLeod RS, Jones PJ.
J Nutr. 2011 Jul;141(7):1286-91. Epub 2011 May 18. PMID: 21593349

Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly.
Plourde M, Chouinard-Watkins R, Vandal M, Zhang Y, Lawrence P, Brenna JT, Cunnane SC.
Nutr Metab (Lond). 2011 Jan 27;8:5. PMID: 21272363

Early Docosahexaenoic Acid Supplementation of Mothers during Lactation Leads to High Plasma Concentrations in Very Preterm Infants.
Marc I, Plourde M, Lucas M, Sterescu A, Piedboeuf B, Dufresne A, Nuyt AM, Lévy E, Dodin S.
J Nutr. 2011 Feb;141(2):231-6. Epub 2010 Dec 15. PMID: 21169226

Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects.
Tremblay-Mercier J, Tessier D, Plourde M, Fortier M, Lorrain D, Cunnane SC.
J Pharmacol Exp Ther. 2010 Jul;334(1):341-6. Epub 2010 Apr 19. PMID: 20404010

Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: higher fish intake or aging-related change in n-3 fatty acid metabolism?
Fortier M, Tremblay-Mercier J, Plourde M, Chouinard-Watkins R, Vandal M, Pifferi F, Freemantle E, Cunnane SC.
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):277-80. Epub 2010 Mar 4. PMID: 20206489

Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men.
Plourde M, Vohl MC, Vandal M, Couture P, Lemieux S, Cunnane SC.
Br J Nutr. 2009 Oct;102(8):1121-4.PMID: 19828088

Fish, docosahexaenoic acid and Alzheimer's disease.
Cunnane SC, Plourde M, Pifferi F, Bégin M, Féart C, Barberger-Gateau P.
Prog Lipid Res. 2009 Sep;48(5):239-56. Epub 2009 Apr 10. PMID: 19362576

Metabolic response to a ketogenic breakfast in the healthy elderly.
Freemantle E, Vandal M, Tremblay Mercier J, Plourde M, Poirier J, Cunnane SC.
J Nutr Health Aging. 2009 Apr;13(4):293-8. PMID: 19300863

n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations.
Lucas M, Asselin G, Plourde M, Cunnane SC, Dewailly E, Dodin S.
Public Health Nutr. 2010 Jan;13(1):63-70. Epub 2009 May 12.PMID: 19433004

Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate.
Pifferi F, Tremblay S, Plourde M, Tremblay-Mercier J, Bentourkia M, Cunnane SC.
Epilepsia. 2008 Nov;49 Suppl 8:76-9. Review.PMID: 19049595

Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly.
Plourde M, Tremblay-Mercier J, Fortier M, Pifferi F, Cunnane SC.
Nutrition. 2009 Mar;25(3):289-94. Epub 2008 Nov 26.PMID: 19036560

Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly.
Vandal M, Freemantle E, Tremblay-Mercier J, Plourde M, Fortier M, Bruneau J, Gagnon J, Bégin M, Cunnane SC.
Lipids. 2008 Nov;43(11):1085-9. Epub 2008 Sep 16.PMID: 18795357

Conjugated linoleic acids: why the discrepancy between animal and human studies?
Plourde M, Jew S, Cunnane SC, Jones PJ.
Nutr Rev. 2008 Jul;66(7):415-21. Review.PMID: 18667017

Chapitres de livre / Contributions à un ouvrage collectif

Fatty acid intake and cognitive decline. 
Plourde M
In: Lifetime nutritional influences on cognition, behaviour and psychiatric illness, David Benton (ed), Woodhead Publishing Ltd, Abington, Cambridge, UK, 2011, 525-542.

What Is the Link between Docosahexaenoic Acid, Cognitive Impairment, and Alzheimer’s Disease in the Elderly?.
Bégin ME, Plourde M, Pifferi F, Cunnane SC.
In: Montmayeur JP, le Coutre J, editors. Fat Detection: Taste, Texture, and Post Ingestive Effects. Boca Raton (FL): CRC Press; 2009, p. 485-506. Chapter 19. PMID: 21452466

Plourde M, Fatty acid intake and cognitive decline. In Lifetime nutritional influences on cognition. In Behaviour and psychiatric illness, David Benton (ed), Woodhead Publishing Ltd, Abington, Cambridge, UK, 2010.

Plourde M. Does altered omega-3 fatty acid metabolism contributing to cognitive aging? In Cognitive Aging: Causes, Processes and Effects. Columbus F (ed), Nova Science Publishers, Hauppauge, NY, USA, 2009, p. 305-332.

Bégin ME, Plourde M, Pifferi F, and Cunnane SC. Are fish and docosahexaenoic acid linked to lower cognitive decline and Alzheimer’s disease? In New Research on Nutrition in the prevention of Alzheimer's disease, Ramassamy C and Bastianetto S (eds), Research Signpost/Transworld Research Network, Philadelphia, PA, USA, 2010, p. 71-96.

Bégin ME, Plourde M, Pifferi F, and Cunnane SC. What is the link between DHA, progressive cognitive deterioration and Alzheimer’s disease in the elderly? In Fat Detection: Taste, Texture, and Post Ingestive Effects, Montmayeur JP and Le-Coutre J (eds). CRC Press Taylor and Francis Group, Boca Raton, FL, USA, 2009, 485-506.

Résumés

Conway V, Allard MJ, Minihane AM, Jackson KG, Lovegrove JA, Plourde M. Postprandial omega-3 fatty acids in lipoproteins: lack of an interaction with apolipoprotein E epsilon 4 genotype. 11th Biennial International Society for the Study of Fatty Acids and Lipid Congress, Stockholm, Sweden, 28th June-2nd July 2014.

Conway V, Larouche A, Alata W, Vandal M, Calon F, Plourde M. Human apolipoprotein E epsilon 4 genotype disrupts fatty acids distribution in organs of transgenic mice. 11th Biennial International Society for the Study of Fatty Acids and Lipid Congress, Stockholm, Sweden, 28th June-2nd July 2014.

Plourde M. The story of apolipoprotein E epsition 4 genotype and docosahexaenoic acid metabolism: data from mice and humans. 11th Biennial International Society for the Study of Fatty Acids and Lipid Congress, Stockholm, Sweden, 28th June-2nd July 2014.

Chouinard-Watkins R, Vandal M, Calon F, Plourde M. A diet rich in DHA prevent visual and spatial memory loss in 12 months old mice carrying the human apolipoprotein E ɛ4 polymorphism. 11th Biennial International Society for the Study of Fatty Acids and Lipid Congress, Stockholm, Sweden, 28th June-2nd July 2014.

Chouinard-Watkins R, Minihane AM, Jackson KG, Lovegrove JA, Plourde M. Interaction between diet and APOE genotype on relative % of total saturated fatty acids and docosapentaenoic acid in plasma lipid classes. 11th Biennial International Society for the Study of Fatty Acids and Lipid Congress, Stockholm, Sweden, 28th June-2nd July 2014.

Conway V, Allard MJ, Rioux-Perreault C, Minihane AM, Jackson KG,Lovegrove JA, Plourde M. Post-prandial transport of omega-3 fatty acids : Lack of an interaction with apolipoprotein E epsilon 4 genotype? International Society of Nutrigenetics and Nutrigenomics, Quebec, Canada, 5-8th October 2013.

Dang MTM, Rioux-Perreault C, Plourde M. Transport of omega-3 fatty acids in lipoproteins according to apolipoprotein E genotype. International Society of Nutrigenetics and Nutrigenomics, Quebec, Canada, 5-8th October 2013.

Plourde M, Chouinard-Watking R, Rioux-Perreault C, Fortier M, Dang MTM, Allard MJ, Tremblay-Mercier J, Zhang Y, Lawrence P, Wohl M, Perron P, Lorrain D, Brenna T, Cunnane S. 13C-DHA Metabolism before and after a fish oil supplement in healthy older humans. 11e édition des Journées de la recherche du Réseau québécois de recherche sur le vieillissement, Québec, Canada, 1er octobre 2013.

Castellano CA, Baillargeon JP, Plourde M, Matte JJ. L’acide alpha-linolénique conjugué (CLNA) peut-il contrer le surpoids et la résistance à l’insuline? Journée scientifique duDocc, Sherbrooke, Canada, 23rd May 2013.

Chouinard-Watkins R, Lorrain D, Viens I, Normand MP, Perron P, Rioux-Perreault C, Cunnane S, Plourde M.  Performances cognitives et huile de poisson: où en sommes-nous rendu dans les connaissances? 9e journée scientifique du centre de recherche sur le vieillissement, Sherbrooke, 9th November 2012.(As a new investigator)

Chouinard-Watkins R, Lorrain D, Viens I, Normand MP, Perron P, Rioux-Perreault C, Cunnane S, Plourde M, Performances cognitives avant et après une supplémentation en huile de poisson.  Journée du centre des neurosciences de Sherbrooke, Sherbrooke, 11th December 2012. (As a new investigator)

Dang TM, Rioux-Perreault C, Plourde M. Réponse de biomarqueurs à la suite d’une consommation d’acides gras oméga-3. Journée du centre des neurosciences de Sherbrooke, Sherbrooke, 11th Décember 2012. (As a new investigator)

Allard MJ, Rioux-Perreault C, Minihane AM, Jackson KG, Lovegrove J, Plourde M. Transport des acides gras oméga-3 en post-prandial : Interaction avec le génotype de l’Apolipoprotéine E epsilon 4? Journée du centre des neurosciences de Sherbrooke, Sherbrooke, 11th Décember 2012. (As a new investigator)

Chouinard-Watkins R, Zhang Y, Lawrence P, Lorrain D, Perron P, Brenna JT, Cunnane SC,

Plourde M. Métabolisme de l’acide docosahexaénoïque marqué au carbone 13 avant et après une supplémentation en huile de poisson. 9e journée scientifique du centre de recherche sur le vieillissement, Sherbrooke, 9th November 2012. (As a new investigator)

Dang TM, Rioux-Perreault C, Plourde M. Réponse de biomarqueurs à la suite d’une consommation d’acides gras oméga-3. 9e journée scientifique du centre de recherche sur le vieillissement, Sherbrooke, 9th November 2012. (As a new investigator)

Allard MJ, Rioux-Perreault C, Minihane AM, Jackson KG, Lovegrove J, Plourde M. Transport des acides gras oméga-3 en post-prandial : Interaction avec le génotype de l’Apolipoprotéine E epsilon 4? 9e journée scientifique du centre de recherche sur le vieillissement, Sherbrooke, 9th November 2012. (As a new investigator)

Chouinard-Watkins R, Lorrain D, Viens I, Normand MP, Perron P, Rioux-Perreault C, Cunnane S, Plourde M, Performances cognitives avant et après une supplémentation en huile de poisson. 10e journée scientifique du Réseau québécois de recherche sur le vieillissement, Montréal, 1st and 2nd October 2012. (As a new investigator)

Chouinard-Watkins R, Rioux-Perreault C, Zhang Y, Lawrence P, Brenna JT, Cunnane SC, Plourde M. Métabolisme de l’acide docosahexaénoïque selon le génotype de l’apolipoprotéine E epsilon 4. 9e Journée du Réseau québécois de recherche sur le vieillissement, Magog, Canada, 6-7th October 2011. (As a new investigator)

Rioux-Perreault C., Focillon C., Chouinard-Watkins R., Cunnane S.C., Plourde M. Débalancement de la distribution des acides gras oméga-3 chez les porteurs de l’APOE4. 9e Journée du Réseau québécois de recherche sur le vieillissement, Magog, Canada, 6-7th October 2011. (As a new investigator)

Beltempo M, Bélanger S, Sterescu A, Plourde M, Lucas M, Piedboeuf B, Dufresne A, Njoya M, Nuyt AM, Lévy E, Dodin S, Marc I. Impact of docosahexaenoic acid supplementation on neonatal outcomes and development in very preterm infants, 88th CPS Annual Conference, Quebec, Canada, 15-18th June 2011. (As a new investigator)

 Plourde M. Captation cérébrale de l’acide docosahexaénoïque chez les souris porteuses de l’apolipoprotéine E epsilon 4 humaine. 79e congrès de l’ACFAS, Sherbrooke, Canada, 9-12th May 2011. (As a new investigator)

Chouinard-Watkins R, Plourde M, Viens I, Vigneault M, Fortier M, Lorrain D, Brenna JT, Cunnane SC. Métabolisme de l’acide docosahexaénoïque selon le génotype de l’apolipoprotéine E epsilon 4. 79e congrès de l’ACFAS, Sherbrooke, Canada, 9-12th May 2011. (As a newinvestigator)

Chouinard-Watkins R, Plourde M, Zhang Y, Lawrence P, Brenna JT, Cunnane SC. 13C-DHA metabolism before and after an omega-3 fatty acids supplementation. Lipids and brain 2, Paris,France, 28-30th March 2011. (As a new investigator)

Chouinard-Watkins R, Plourde M, Viens I, Vigneault M, Fortier M, Lorrain D, Brenna JT, Cunnane SC, Métabolisme de l’acide docosahexaénoïque selon le génotype de l’apolipoprotéine E. Journée de la recherche, Faculté de médecine et des sciences de la santé, Sherbrooke, Canada, 22nd March 2011. (As a new investigator)

Plourde, M.Vieillissement, nutrition et génétique : comprendre leurs interactions pour prévenir le déclin cognitif. Faculty of Medicine and Health Science. Université de Sherbrooke, Sherbrooke, Canada, 29th October 2010.

Plourde M.Omega-3 FA and non-cardiovascular Health Benefits. Canadian Nutrition Society, Edmonton, Canada, 3-5th June 2010.

Marc I, Plourde M, Lucas M, Dufresne A, Piedboeuf P, Dodin S.Docosahexaenoic acid in plasma of very premature infants: Impact of an early supplementation of the mother during lactation. 9th Biennial Scientific Meeting of ISSFAL, Maastricht, The Netherlands, 29th May-2nd June 2010.

Plourde M,Chouinard-Watkins R, Vandal M, Zhang Y, Lawrence P, Brenna JT, Cunnane SC. Altered metabolism of 13C-docosahexaenoic acid during healthy aging. 9th Biennial International Meeting of ISSFAL, Maastricht, The Netherlands, 29th May-2nd June 2010.

Plourde M.Does altered EPA and DHA metabolism contributing to cognitive decline: impact of aging and ApoE4, 9th Biennial International Meeting of ISSFAL, Maastricht, The Netherlands, 29th May-2nd June 2010.

Marc I, Plourde M, Lucas M, Dufresne A, Piedboeuf P, Dodin S.Docosahexaenoic acid in plasma of very premature infants: Impact of an early supplementation of the mother during lactation. DHA Celebration meeting, London, England, 26-27th May 2010.

Plourde M, Vohl MC, Caron-Dorval D, Couture P, Lemieux S, Cunnane SC. Apolipoprotein E4 polymorphism altered levels in EPA and DHA following an omega-3 supplementation. DHA Celebration meeting, London, England, 26-27th May 2010.

Chouinard-Watkins R, Viens I, Fortier M, Tremblay-Mercier J, Lorrain D, Zhang Y, Lawrence P, Brenna JT, Plourde M. DHA metabolism in ApoE4 carriers, AFMNet's 6th Annual Scientific Conference, Halifax, Canada, 26-29th May2010.

Viens I, Chouinard-Watkins R, Fortier M, Tremblay-Mercier J, Lorrain D, Plourde M. Does the link between cognitive scores and plasma omega-3 status is altered by Apolipoprotein E4 polymorphism? AFMNet's 6th Annual Scientific Conference, Halifax, Canada, 26-29th May2010.

Plourde M, Lorrain D, Cunnane SC. Do apolipoprotein E polymorphisms influence risk of cognitive decline by modulating omega-3 fatty acid metabolism? AFMNet's 6th Annual Scientific Conference, Halifax, Canada, 26-29th May2010.

Chouinard-Watkins R, Vandal M, Plourde M, Cunnnane SC. Métabolisme de l’acide docosahexaènoïque lors du vieillissement, 7e Journée scientifique du centre de recherche sur le vieillissement, Magog, Canada, 16th May2010. RCW Awarded the Réjean Hébert price for the best poster.

Marc I, Plourde M, Lucas M, Dufresne A, Piedboeuf P, Dodin S.High dose of docosahexaenoic acid (DHA) for very premature infants: Effects of mother supplementation on breastfed infant fatty acid status.Pediatric Academic Societies' Annual Meeting, Vancouver, Canada, 1-4th May 2010. Media exposure after the conference.

Plourde M, Vohl MC, Bouchard C, Dolley G, Marette A, Pérusse L. Une analyse d’association à l’échelle du génome suggère la présence de gènes communs entre l’obésité et l’inflammation. 11e réunion annuelle de la Société québécoise de lipidologie, nutrition et métabolisme, Québec, Canada, 29th April-1st May 2010.

Rudkowska I, Plourde M, Julien P, Lemieux S, Couture P, Vohl MC. Fatty acids of plasma phospholipids and erythrocytes are reliable biomarkers of n-3 polyunsaturated fatty acid supplementation. FASEB, Anaheim, USA, 24-28th April 2010.

Plourde M., Vieillissement, nutrition et génétique: Comprendre leurs interactions pour prévenir le déclin cognitif. Gérontoclub, 12th March 2010.

Chouinard-Watkins R, Vandal M, Plourde M, Cunnnane SC. Métabolisme de l’acide docosahexaènoïque lors du vieillissement RQRV, Québec, Canada, 27th November 2009. Awarded the best poster

Pérusse L, Plourde M, Bellis C, Dyer T, Carless MA, Després JP, Bouchard C, Marette A, Blangero J, Vohl MC. Genome-wide association studies identifies gene linking abdominal fat, inflammation, and other cardiovascular disease risk factor in the Quebec Family Study. American Heart Association Scientific Sessions, Orlando, USA, 14-18th November 2009.

Plourde M.Genetics, nutrition and aging: Investigating their interactions to prevent cognitive decline. New principal investigator meeting – CIHR, Jackson Point, Canada, 6-8th November 2009.

Pifferi F, Plourde M, Tremblay-Mercier J, Tremblay S, Bégin ME, Cunnane SC. Do problems of energy substrate supply contribute to age-related brain diseases? IAGG World Congress, Paris, France, 5-9th July 2009.

Plourde M, Cunnane SC. Do apolipoprotein E polymorphisms influence risk of cognitive decline by modulating omega-3 fatty acid metabolism? AFMNet's 5th Annual Scientific Conference, Guelph, Canada, 11-14th June 2009

Plourde M, Vohl MC, Cunnane SC. Métabolisme des acides gras oméga-3, génétique et cognition : existe-t-il un lien entre ces facteurs? 6e Journée scientifique du Centre de recherchesur le vieillissement, Magog, Canada, 8th May 2009. Awarded the best oral presentation

Pifferi F, Plourde M, Cunnane SC. Imaging brain fuel uptake in the elderly : Implication for understanding the link between cognition and brain metabolism. Uppsala, Sweden, 12th March 2009.

Plourde M, Fortier M, Vandal M, Tremblay-Mercier J, Bégin M, Pifferi F, Cunnane SC. Unresolved issues in the link between docosahexaenoic acid and Alzheimer disease. Brain Lipids Conference, Oslo, Norway, 8-11th September 2008.

Plourde M, Vohl MC, Caron-Dorval D, Couture P, Lemieux S, Cunnane SC. Apolipoprotein E4 polymorphism influence plasma omega-3 incorporation in adult men following an omega-3 supplementation. Brain Lipids Conference, Oslo, Norway, 8-11th September 2008.

Plourde M, Tremblay-Mercier J, Fortier M, Cunnane SC. Omega-3 supplementation lowers plasma b-hydroxybutyrate and free fatty acids concentrations in healthy young and elderly adults. CFBS annual meeting, Winnipeg, Canada, 17-20th June 2008.

Plourde M, Fortier M, Vandal, M, Tremblay-Mercier J, Freemantle E, Bégin M, Pifferi F, Cunnane SC. Unresolved issues in the link between docosahexaenoic acid and Alzheimer disease. Winnipeg, Canada, CFBS annual meeting, 17-20th June 2008.

Pifferi F, Plourde M, Tremblay-Mercier J, Vandal M, Freemantle E, Tremblay S, Fortier M, Bégin M, Cunnane SC. Is the aging brain starving? Symposium Nutrition and cerebral functions, Quebec, Canada, 22-23rd May 2008.

Vandal M, Pifferi F, Plourde M, Freemantle E, Zhang Y, Tremblay-Mercier J, Fortier M, Bégin M, Brenna JT, Cunnane SC. DHA metabolism in the healthy elderly. 8th Biennial International Scientific Meeting of ISSFAL, Kansas City, USA, 17-22nd May 2008.

Plourde M, Tremblay-Mercier J, Fortier M, Cunnane SC. Omega-3 supplementation lowers plasma b-hydroxybutyrate and free fatty acids concentrations in healthy young and elderly adults. 8th Biennial International Scientific Meeting of ISSFAL, Kansas City, USA, 17-22nd May 2008.

Plourde M, Fortier M, Vandal, M, Tremblay-Mercier J, Freemantle E, Bégin M, Pifferi F, Cunnane SC. Unresolved issues in the link between docosahexaenoic acid and Alzheimer disease. 8th Biennial International Scientific Meeting of ISSFAL, Kansas City, USA, 17-22nd May 2008.

Plourde M,Vohl MC, Caron-Dorval D, Couture P, Lemieux S, Cunnane SC. Apolipoprotein E and PPAR-aL162V polymorphisms influence plasma omega-3 response. 8th Biennial International Scientific Meeting of ISSFAL, Kansas City, USA, 17-22nd May 2008.

Vandal M, Zhang Y, Plourde M, Fortier M, Tremblay-Mercier J, Pifferi F, Bégin M, Windust A, Brenna T and Cunnane SC. 13C-DHA metabolism during aging. Société Québécoise de Lipidologie, Nutrition et Métabolisme, Laval, Canada, 1-3rd May 2008.

Tremblay-Mercier J, Fortier M, Plourde M, Vandal M, Cunnane SC. Impact of Bezafibrate on plasma lipids and ketones in 8 subjects with slight hypertriglyceridemia. Société Québécoise de Lipidologie, Nutrition et Métabolisme, Laval, Canada, 1-3rd May 2008.

Plourde M, Vohl MC, Caron-Dorval D, Couture P, Lemieux S, Cunnane SC. Impact of ApoE4 and PPAR-alpha L162V polymorphisms on plasma omega-3 fatty acid incorporation. Société Québécoise de Lipidologie, Nutrition et Métabolisme, Laval, Canada, 1-3rd May 2008.

Pifferi F, Tremblay S,Plourde M, Tremblay-Mercier J, Bentourkia M, Cunnane SC. Ketones, intractable seizures and brain function: Possible links involving polyunsaturated fatty acids (PUFA), and availability of carbon-11 acetoacetate (11C-AcAc) - a new tracer for brain PET studies. International symposium on dietary therapies for epilepsy and other neurological disorders, Phoenix, Arizona, 2-5th  April 2008.

Plourde M. Omega-3 fatty acids, cognition and aging. Lipids, multiple sources of functional foods and nutraceuticals, Centre Québécois de valorisation de la biomasse, Québec, Canada, 27th March 2008.

Plourde M. Fueling the aging brain: Roles of ketones and omega-3 fatty acids.Faculty of Medicine and Health Science, Université de Sherbrooke, 25th January 2008.

Plourde M and Cunnane SC. Omega-3 fatty acids in the maintenance of brain alertness. 2nd symposium of the student-scientists and postdoctoral fellows of the Institute of Nutraceuticals and Functional Foods, Bromont, Canada, 1-2nd November 2007.

Gagnon J, Plourde M, Fortier M, Paradis AM, Vohl MC, Cunnane SC. Ketone production and plasma lipid profile in men carriers of the L162V polymorphism of PPAR-α. 3rd edition of undergraduate Scientific Day, Sherbrooke, Canada, 28th September 2007.

Cunnane SC, Vandal M, Tremblay-Mercier J, Plourde M, Freemantle E, Tremblay S, Bégin M. Linking low docosahexaenoic acid to Alzheimer's disease: caution recommended.8th Fatty Acids in Cells Signalling meeting, Québec, Canada, 26-28th June 2007.

Plourde M, Jew J, Cunnane SC, Jones P.Conjugated linoleic acids: Why the discrepancy between animal and human studies? Canadian Workshop on Conjugated Linoleic Acid 2007, Winnipeg, Canada, 18thJune 2007.

Plourde M, Jew J, Cunnane SC, Jones P.Conjugated linoleic acids: Why the discrepancy between animal and human studies? Canadian Nutrition Congress,Winnipeg, Canada 18-21st June 2007.

Plourde M and Cunnane SC. How much ALA do humans convert to EPA and DHA and what are the health implications? Canadian Nutrition Congress, Winnipeg, Canada 18-21st June 2007.

Plourde M and Cunnane SC. Very limited synthesis of long chain polyunsaturates in adults: A review. 98th Annual Meeting of the AOCS, Québec, Canada, 13-16th May 2007.

Tremblay-Mercier J, Freemantle E, Vandal M, Plourde M, Tremblay S, Bégin ME, Morris MC, Schneider J, Cunnane SC. Omega-3 PUFA, brain energy substrates and brain function during aging. AFECG and DGF Joint Meeting on PUFA Metabolism, Function and Protection Against Diseases, Paris, France, 13-14th March 2007.

Tremblay-Mercier J, Freemantle E, Vandal M, Bruneau J, Plourde M, Tremblay S, Bégin M, Cunnane SC. Genetics, omega-6 and omega 3 fatty acid metabolism and brain function during early development and aging. A symposium of the Letten and Mother and Child Foundations. London, United Kingdom, 21-24th October 2006.

Vandal M, Tremblay-Mercier J, Freemantle E, Bruneau J, Plourde M, Tremblay S, Bégin M, Cunnane SC. Fatty acids and brain function across the lifespan : Dual roles as indirect energy substrates and as membrane components. CAOCS, Longueuil, Canada, 1-3rd October 2006.

Plourde M,Angers P, Sébédio JL. Evaluation of the physiological effects of conjugated alpha-linolenic acids. 13th International Union of Food Science & Technology World Congress(IUFOST), Nantes, France, 17-21st September, 2006.

Plourde M,Ledoux M, Fontaine JJ, Portois L, Carpentier Y, Chardigny JM, Grégoire S, Angers P, Sébédio JL. Comparative effects of rumenic acid and conjugated a-linolenic acids (CLnAs) on experimental atherosclerosis in hamsters. Société Québécoise de Lipidologie, de Nutrition et de Métabolisme,Québec, Canada, 27-29th April 2006.

Plourde M,Sergiel JP, Chardigny JM,Grégoire S, Angers P, Sébédio JL. Absorption and metabolism of conjugated a-linolenic acid given as free fatty acids or triacylglycerols in rats. Symposium INAF, Québec, Canada, 6-7th October 2005.

Plourde M,Ledoux M, Fontaine JJ, Portois L, Carpentier Y, Chardigny JM, Grégoire S, Angers P, Sébédio JL. Comparative effects of rumenic acid and conjugated a-linolenic acids (CLnAs) on experimental atherosclerosis in hamsters. Symposium INAF, Québec, Canada, 6-7th October 2005.

Plourde M,Ledoux M, Fontaine JJ, Portois L, Carpentier Y, Chardigny JM, Grégoire S, Angers P, Sébédio JL. Comparative effects of rumenic acid and conjugated a-linolenic acids (CLnAs) on experimental atherosclerosis in hamsters. 26th World Congress and Exhibition of the ISF, Prague, Czech Republic, 25-27th September 2005.

Plourde M,Sergiel JP, Chardigny JM,Grégoire S, Angers P, Sébédio JL. Absorption and metabolism of conjugated a-linolenic acid given as free fatty acids or triacylglycerols in rats. Symposium STELA, Sainte-Foy, Canada, 30-31st May 2005.

Plourde M,Chardigny JM,Grégoire S, Angers P, Sébédio JL. Effect of conjugated a-linolenic acid (CLnA) on feed intake. 96th AOCS Annual Meeting & Expo,Salt Lake City, USA, 1-4th May 2005.