Pr Stephen Cunnane, Ph. D.
Professeur titulaire

Titulaire d'une chaire de recherche sur le métabolisme cérébral et la cognition au cours du vieillissement de la Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke.

Chercheur de l'axe «Clinique » du Centre de recherche sur le vieillissement du CSSS-IUGS, et du thème porteur « Vieillissement » de la Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke.
Service d'endocrinologie
Département de médecine
Faculté de médecine et des sciences de la santé
Université de Sherbrooke
Institut universitaire de gériatrie de Sherbrooke
1036, rue Belvédère Sud
Sherbrooke (Québec)  J1H 4C4

Téléphone :   819 780-2220, poste 45670
Télécopieur :  819 829-7141

Courriel : Stephen.Cunnane@USherbrooke.ca
Appartenance mineure

Département de physiologie et biophysique.

Études postdoctorales

Aberdeen, London, 1980-1982

Études doctorales

Doctorat en physiologie
Université McGill
Montréal, 1980

Thème porteur de recherche

Vieillissement.

Axe de recherche

Biologie et physique du CDRV CSSS-IUGS.

Subventions de recherche en cours

Métabolisme cérébral et cognition au cours du vieillissement.

Chercheur principal : Cunnane S

Organisme subventionnaire : 
Chaire de recherche
Faculté de médecine et des sciences de la santé
Université de Sherbrooke
(10/2012-09/2018)

Brain Fuel Uptake and Cognitive Decline in the Elderly.

Chercheur principal : Cunnane S
Co-chercheurs : Bentourkia M, Fülöp T, Tessier D, Turcotte E.

Organisme subventionnaire : 
IRSC/CIHR
(01/04/2010-31/03/2015)

Fatty acid and ketone metabolism in the healthy elderly.

Chercheur principal : Cunnane S

Organisme subventionnaire : 
Conseil de recherche en sciences naturelles et génie du Canada (CRSNG)
(04/2008-03/2013)

Supervision d'étudiants - 5 dernières années

(2e, 3e cycles et stagiaires postdoctoraux)
En cours
Castellano, Alexandre

Programme : 

Diplôme : Fellow postdoctoral / en cours

Titre de la recherche :  Insulin resistance and brain metabolism.

Bourse :  --

Directeur : Cunnane S

Courchesne-Loyer, Alex

Programme :  Physiologie

Diplôme : Ph. D. / en cours

Titre de la recherche :  Stimulating ketogenesis and brain ketone uptake in he elderly.

Bourse :  --

Directeur : Cunnane S

Hennebelle, Marie

Programme : 

Diplôme : Stagiaire postdoctorale / en cours

Titre de la recherche :  Métabolisme des acides gras oméga-3 et déclin cognitif en lien avec le vieillissement.

Bourse :  --

Directeur : Cunnane S

Nugent, Scott

Programme :  Physiologie

Diplôme : Ph. D. / en cours

Titre de la recherche :  Brain energy metabolism by PET.

Bourse :  --

Directeur : Cunnane S

Roy, Maggie

Programme :  Physiologie

Diplôme : Ph. D. / En cours

Titre de la recherche :  Brain energy metabolism in cognitive decline.

Bourse :  --

Directeur : Cunnane S

St-Pierre, Valérie

Programme :  Physiologie

Diplôme : M.Sc. / en cours

Titre de la recherche : Cétose légère stimulée par certains suppléments nutritionnels.

Bourse :  --

Directeur : Cunnane S

Supervision terminée
Authier, S

Programme : Radiobiologie et médecine nucléaire

Diplôme : M. Sc. obtenue en 2009

Titre de la recherche : 11C-acetoacetate metabolism in mice.

Bourse : --

Directeur : Cunnane S
Co-directeur : Bérard F

Bégin, Michel

Programme :

Diplôme :  Fellow postdoctoral / fin 2009

Titre de la recherche : Thyroid function, cognition and aging.

Bourse : Centre de recherche sur le vieillissement.

Directeur : Cunnane S

Chouinard-Watkins, Raphael

Programme : Physiologie

Diplôme : M. Sc. obtenue en 2012

Titre de la recherche : ApoE4, omega-3 fatty acids and aging.

Bourse : --

Directeur : Cunnane S

Courchesne-Loyer, Alex

Programme :  Physiologie

Diplôme : M. Sc. obtenue en 2012

Titre de la recherche :  Ketone and brain function during aging.

Bourse :  --

Directeur : Cunnane S

Pifferi, Fabien

Programme : 

Diplôme : Fellow postdoctoral / fin 2009

Titre de la recherche : Étude de la captation cérébrale du glucose et des corps cétoniques au cours du vieillissement.

Bourse : Bourse de fellowship du Département de médecine, FMSS, Université de Sherbrooke (2008-2009)

Directeur : Cunnane S

Plourde, Mélanie

Programme :

Diplôme : Fellow postdoctoral / fin 2009

Titre de la recherche : Est-ce que certains acides gras alimentaires stimulent la formation des corps cétoniques - le carburant alternatif pour le cerveau vieillissant?  Effet des acides gras alimentaires sur les corps cétoniques plasmatiques et sur la cognition.

Bourse : FRSQ (2008-2010) et Bourse de fellowship du Département de médecine, FMSS, Université de Sherbrooke (2006-2008)

Directeur : Cunnane S

Tremblay-Mercier, Jennifer

Programme : Physiologie et biophysique

Diplôme : M. Sc. obtenue en 2009

Titre de la recherche : Fibrates and ketogenesis in the elderly.

Bourse : Centre de neurosciences de Sherbrooke.

Directeur : Cunnane S

Publications d'articles (2010-....)

Lower Brain 18F-Fluorodeoxyglucose Uptake But Normal 11C-Acetoacetate Metabolism in Mild Alzheimer's Disease Dementia.
Castellano CA, Nugent S, Paquet N, Tremblay S, Bocti C, Lacombe G, Imbeault H, Turcotte É, Fulop T, Cunnane SC.
J Alzheimers Dis. 2015 Jan 1;43(4):1343-53. doi: 10.3233/JAD-141074. PMID: 25147107

[(11)C]-Acetoacetate PET imaging: a potential early marker for cardiac heart failure.
Croteau E, Tremblay S, Gascon S, Dumulon-Perreault V, Labbé SM, Rousseau JA, Cunnane SC, Carpentier AC, Bénard F, Lecomte R.
Nucl Med Biol. 2014 Nov-Dec;41(10):863-70. doi: 10.1016/j.nucmedbio.2014.08.006. Epub 2014 Aug 13. PMID: 25195015

Gene expression of fatty acid transport and binding proteins in the blood-brain barrier and the cerebral cortex of the rat: differences across development and with different DHA brain status.
Pélerin H, Jouin M, Lallemand MS, Alessandri JM, Cunnane SC, Langelier B, Guesnet P.
Prostaglandins Leukot Essent Fatty Acids. 2014 Nov;91(5):213-20. doi: 10.1016/j.plefa.2014.07.004. Epub 2014 Jul 21. PMID: 25123062

Energetic and nutritional constraints on infant brain development: implications for brain expansion during human evolution.
Cunnane SC, Crawford MA.
J Hum Evol. 2014 Dec;77:88-98. doi: 10.1016/j.jhevol.2014.05.001. Epub 2014 Jun 11. PMID: 24928072

Kinetics of 13C-DHA before and during fish-oil supplementation in healthy older individuals.
Plourde M, Chouinard-Watkins R, Rioux-Perreault C, Fortier M, Dang MT, Allard MJ, Tremblay-Mercier J, Zhang Y, Lawrence P, Vohl MC, Perron P, Lorrain D, Brenna JT, Cunnane SC.
Am J Clin Nutr. 2014 May 14;100(1):105-112. [Epub ahead of print]
PMID: 24829492

Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults.
Nugent S, Castellano CA, Goffaux P, Whittingstall K, Lepage M, Paquet N, Bocti C, Fulop T, Cunnane SC.
Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1315-21. doi: 10.1152/ajpendo.00067.2014. Epub 2014 Apr 15. PMID: 24735889

RE: Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial.
Brenna JT, Burdge GC, Crawford MA, Clayton P, Cunnane SC, Gow R, Hibbeln JR, Sinclair AJ, Stein J, Willatts P.
J Natl Cancer Inst. 2014 Apr;106(4):dju015. doi: 10.1093/jnci/dju015. Epub 2014 Mar 31. No abstract available.  PMID: 24685922

A dual tracer PET-MRI protocol for the quantitative measure of regional brain energy substrates uptake in the rat.
Roy M, Nugent S, Tremblay S, Descoteaux M, Beaudoin JF, Tremblay L, Lecomte R, Cunnane SC.
J Vis Exp. 2013 Dec 28;(82):50761. doi: 10.3791/50761. PMID: 24430432

Brain glucose and acetoacetate metabolism: a comparison of young and older adults.
Nugent S, Tremblay S, Chen KW, Ayutyanont N, Roontiva A, Castellano CA, Fortier M, Roy M, Courchesne-Loyer A, Bocti C, Lepage M, Turcotte E, Fulop T, Reiman EM, Cunnane SC.
Neurobiol Aging. 2014 Jun;35(6):1386-95. doi: 10.1016/j.neurobiolaging.2013.11.027. Epub 2013 Dec 1. PMID: 24388785 

Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline.
Hennebelle M, Plourde M, Chouinard-Watkins R, Castellano CA, Barberger-Gateau P, Cunnane SC.
Proc Nutr Soc. 2014 Feb;73(1):80-6. doi: 10.1017/S0029665113003625. Epub 2013 Oct 9. Review. PMID: 24103099

A dual tracer PET-MRI protocol for the quantitative measure of regional brain energy substrates uptake in the rat.
Roy M, Nugent S, Tremblay S, Descoteaux M, Beaudoin JF, Tremblay L, Lecomte R, Cunnane SC.
J Vis Exp. 2013 Dec 28;(82):50761. doi: 10.3791/50761. PMID:24430432

Brain glucose and acetoacetate metabolism: a comparison of young and older adults.
Nugent S, Tremblay S, Chen KW, Ayutyanont N, Roontiva A, Castellano CA, Fortier M, Roy M, Courchesne-Loyer A, Bocti C, Lepage M, Turcotte E, Fulop T, Reiman EM, Cunnane SC.
Neurobiol Aging. 2013 Dec 1. pii: S0197-4580(13)00611-8. doi: 10.1016/j.neurobiolaging.2013.11.027. [Epub ahead of print] PMID:24388785

Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline.
Hennebelle M, Plourde M, Chouinard-Watkins R, Castellano CA, Barberger-Gateau P, Cunnane SC.
Proc Nutr Soc. 2013 Oct 9:1-7. [Epub ahead of print] PMID:24103099

Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy.
Umhau JC, Zhou W, Thada S, Demar J, Hussein N, Bhattacharjee AK, Ma K, Majchrzak-Hong S, Herscovitch P, Salem N Jr, Urish A, Hibbeln JR, Cunnane SC, Rapoport SI, Hirvonen J.
PLoS One. 2013 Oct 2;8(10):e75333. doi: 10.1371/journal.pone.0075333. eCollection 2013. PMID:24098376

Long-term calorie restriction has minimal impact on brain metabolite and fatty acid profiles in aged rats on a Western-style diet.
Roy M, Hennebelle M, St-Pierre V, Courchesne-Loyer A, Fortier M, Bouzier-Sore AK, Gallis JL, Beauvieux MC, Cunnane SC.
Neurochem Int. 2013 Nov;63(5):450-7. doi: 10.1016/j.neuint.2013.08.006. Epub 2013 Aug 22. PMID:23974047

Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype.
Samieri C, Lorrain S, Buaud B, Vaysse C, Berr C, Peuchant E, Cunnane SC, Barberger-Gateau P.
J Lipid Res. 2013 Sep;54(9):2559-67. doi: 10.1194/jlr.P036475. Epub 2013 Jun 25. PMID:23801662

Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study.
Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE.
Nutr Res. 2013 May;33(5):367-75. doi: 10.1016/j.nutres.2013.02.012. Epub 2013 Apr 1. PMID:23684438

Thyroid function and cognition in the euthyroid elderly: a case-control study embedded in Quebec longitudinal study - NuAge.
Castellano CA, Laurin D, Langlois MF, Fortier M, Tessier D, Gaudreau P, Ferland G, Payette H, Lorrain D, Cunnane SC.
Psychoneuroendocrinology. 2013 Sep;38(9):1772-6. doi: 10.1016/j.psyneuen.2013.02.013. Epub 2013 Mar 16. PMID:23507188

Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele.
Chouinard-Watkins R, Rioux-Perreault C, Fortier M, Tremblay-Mercier J, Zhang Y, Lawrence P, Vohl MC, Perron P, Lorrain D, Brenna JT, Cunnane SC, Plourde M.
Br J Nutr. 2013 Nov;110(10):1751-9. doi: 10.1017/S0007114513001268. Epub 2013 Apr 30. No abstract available. PMID: 23631810

Elusive Alzheimer's disease: Can immune signatures help our understanding of this challenging disease? Part 2: New immune paradigm.
Fulop T, Lacombe G, Cunnane S, Le Page A, Dupuis G, Frost EH, Bourgade-Navarro K, Goldeck D, Larbi A, Pawelec G.
Discov Med. 2013 Jan;15(80):33-42. PMID: 23375012

Elusive Alzheimer's disease: Can immune signatures help our understanding of this challenging disease? Part 1: Clinical and historical background.
Fulop T, Lacombe G, Cunnane S, Le Page A, Dupuis G, Frost EH, Bourgade-Navarro K, Goldeck D, Larbi A, Pawelec G.
Discov Med. 2013 Jan;15(80):23-32. PMID: 23375011

Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: Estimated potential contribution to brain energy metabolism.
Courchesne-Loyer A, Fortier M, Tremblay-Mercier J, Chouinard-Watkins R, Roy M, Nugent S, Castellano CA, Cunnane SC.
Nutrition. 2013 Apr;29(4):635-40. doi: 10.1016/j.nut.2012.09.009. Epub 2012 Dec 28. PMID: 23274095

Good fats, bad fats, polyunsaturated fatty acids, and cognition in the elderly.
Cunnane S.
Ann Neurol. 2013 Mar;73(3):438. doi: 10.1002/ana.23726. Epub 2012 Dec 7. PMID: 23225261

Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition.
Gillingham LG, Harding SV, Rideout TC, Yurkova N, Cunnane SC, Eck PK, Jones PJ.
Am J Clin Nutr. 2013 Jan;97(1):195-207. doi: 10.3945/ajcn.112.043117. Epub 2012 Dec 5. PMID: 23221573

Docosahexaenoic acid in translational medicine: The Tenth Fatty Acids and Cell Signaling meeting (FACS-10).
Brenna T, Bazan N, Calder P, Cunnane S.
Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):1. doi: 10.1016/j.plefa.2012.09.006. Epub 2012 Oct 24. No abstract available.  PMID: 23103099

The ketogenic diet increases brain glucose and ketone uptake in aged rats: a dual tracer PET and volumetric MRI study.
Roy M, Nugent S, Tremblay-Mercier J, Tremblay S, Courchesne-Loyer A, Beaudoin JF, Tremblay L, Descoteaux M, Lecomte R, Cunnane SC.
Brain Res. 2012 Dec 7;1488:14-23. doi: 10.1016/j.brainres.2012.10.008. Epub 2012 Oct 9. PMID: 23063891

Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe.
Samieri C, Maillard P, Crivello F, Proust-Lima C, Peuchant E, Helmer C, Amieva H, Allard M, Dartigues JF, Cunnane SC, Mazoyer BM, Barberger-Gateau P.
Neurology. 2012 Aug 14;79(7):642-50. doi: 10.1212/WNL.0b013e318264e394. Epub 2012 Aug 1. PMID: 22855869

n-3 PUFA status affects expression of genes involved in neuroenergetics differently in the fronto-parietal cortex compared to the CA1 area of the hippocampus: effect of rest and neuronal activation in the rat.
Harbeby E, Jouin M, Alessandri JM, Lallemand MS, Linard A, Lavialle M, Huertas A, Cunnane SC, Guesnet P.
Prostaglandins Leukot Essent Fatty Acids. 2012 Jun;86(6):211-20. doi: 10.1016/j.plefa.2012.04.008. Epub 2012 May 10. PMID: 22579067

Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?
Cunnane SC, Chouinard-Watkins R, Castellano CA, Barberger-Gateau P.
Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):61-70. doi: 10.1016/j.plefa.2012.04.006. Epub 2012 May 9. PMID: 22575581

Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease.
Cunnane SC, Schneider JA, Tangney C, Tremblay-Mercier J, Fortier M, Bennett DA, Morris MC.
J Alzheimers Dis. 2012;29(3):691-7. doi: 10.3233/JAD-2012-110629. PMID: 22466064

Linoleic acid recommendations--A house of cards.
Cunnane SC, Guesnet P.
Prostaglandins Leukot Essent Fatty Acids. 2011 Dec;85(6):399-402. Epub 2011 Oct 1. No abstract available. PMID: 21963263

α-Linolenate reduces the dietary requirement for linoleate in the growing rat.
Guesnet P, Lallemand SM, Alessandri JM, Jouin M, Cunnane SC.
Prostaglandins Leukot Essent Fatty Acids. 2011 Dec;85(6):353-60. Epub 2011 Aug 30. PMID: 21880475

Brain and systemic glucose metabolism in the healthy elderly following fish oil supplementation.
Nugent S, Croteau E, Pifferi F, Fortier M, Tremblay S, Turcotte E, Cunnane SC.
Prostaglandins Leukot Essent Fatty Acids. 2011 Nov;85(5):287-91. Epub 2011 Jul 26. PMID: 21795034

Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats.
Pifferi F, Tremblay S, Croteau E, Fortier M, Tremblay-Mercier J, Lecomte R, Cunnane SC.
Nutr Neurosci. 2011 Mar;14(2):51-8. PMID: 21605500

What Is the Link between Docosahexaenoic Acid, Cognitive Impairment, and Alzheimer’s Disease in the Elderly?.
Bégin ME, Plourde M, Pifferi F, Cunnane SC.
In: Montmayeur JP, le Coutre J, editors. Fat Detection: Taste, Texture, and Post Ingestive Effects. Boca Raton (FL): CRC Press; 2010. Chapter 19. PMID: 21452466

n-3 fatty acids and cardiovascular events.
Vos E, Cunnane SC, Lanzmann-Petithory D.
N Engl J Med. 2011 Mar 3;364(9):880-1; author reply 882. No abstract available.
PMID: 21366485

Plasma incorporation, apparent retroconversion and beta-oxidation of 13C-docosahexaenoic acid in the elderly.
Plourde M, Chouinard-Watkins R, Vandal M, Zhang Y, Lawrence P, Brenna JT, Cunnane SC.
Nutr Metab (Lond). 2011 Jan 27;8(1):5. [Epub ahead of print] PMID: 21272363

Brain fuel metabolism, aging, and Alzheimer's disease.
Cunnane S, Nugent S, Roy M, Courchesne-Loyer A, Croteau E, Tremblay S, Castellano A, Pifferi F, Bocti C, Paquet N, Begdouri H, Bentourkia M, Turcotte E, Allard M, Barberger-Gateau P, Fulop T, Rapoport SI.
Nutrition. 2011 Jan;27(1):3-20. Epub 2010 Oct 29. PMID: 21035308

Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects.
Normand-Lauzière F, Frisch F, Labbé SM, Bherer P, Gagnon R, Cunnane SC, Carpentier AC.
PLoS One. 2010 Jun 4;5(6):e10956. PMID: 20532041

Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain.
Croteau E, Lavallée E, Labbe SM, Hubert L, Pifferi F, Rousseau JA, Cunnane SC, Carpentier AC, Lecomte R, Bénard F.
Eur J Nucl Med Mol Imaging. 2010 Aug;37(8):1539-50. Epub 2010 May 2. PMID: 20437239

Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects.
Tremblay-Mercier J, Tessier D, Plourde M, Fortier M, Lorrain D, Cunnane SC.
J Pharmacol Exp Ther.  2010 Jul;334(1):341-6. Epub 2010 Apr 19. PMID: 20404010

Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: higher fish intake or aging-related change in n-3 fatty acid metabolism?
Fortier M, Tremblay-Mercier J, Plourde M, Chouinard-Watkins R, Vandal M, Pifferi F, Freemantle E, Cunnane SC.
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):277-80. Epub 2010 Mar 4. PMID: 20206489

n-3 long-chain fatty acids and regulation of glucose transport in two models of rat brain endothelial cells.
Pifferi F, Jouin M, Alessandri JM, Roux F, Perrière N, Langelier B, Lavialle M, Cunnane S, Guesnet P.
Neurochem Int. 2010 Apr;56(5):703-10. Epub 2010 Feb 11. PMID: 20153394

Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring.
D'Asti E, Long H, Tremblay-Mercier J, Grajzer M, Cunnane SC, Di Marzo V, Walker CD.
Endocrinology. 2010 Apr;151(4):1685-94. Epub 2010 Feb 16. PMID: 20160134

n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations.
Lucas M, Asselin G, Plourde M, Cunnane SC, Dewailly E, Dodin S.
Public Health Nutr. 2010 Jan;13(1):63-70. Epub 2009 May 12.  PMID: 19433004

Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men.
Plourde M, Vohl MC, Vandal M, Couture P, Lemieux S, Cunnane SC.
Br J Nutr. 2009 Oct;102(8):1121-4.  PMID: 19828088

Fish, docosahexaenoic acid and Alzheimer's disease.
Cunnane SC, Plourde M, Pifferi F, Bégin M, Féart C, Barberger-Gateau P.
Prog Lipid Res. 2009 Sep;48(5):239-56. Epub 2009 Apr 10.  PMID: 19362576

Metabolic response to a ketogenic breakfast in the healthy elderly.
Freemantle E, Vandal M, Tremblay Mercier J, Plourde M, Poirier J, Cunnane SC.
J Nutr Health Aging. 2009 Apr;13(4):293-8.  PMID: 19300863

alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans.
Brenna JT, Salem N Jr, Sinclair AJ, Cunnane SC; International Society for the Study of Fatty Acids and Lipids, ISSFAL.
Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):85-91. Epub 2009 Mar 9. Review.  PMID: 19269799

Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids.
Harris WS, Mozaffarian D, Lefevre M, Toner CD, Colombo J, Cunnane SC, Holden JM, Klurfeld DM, Morris MC, Whelan J.
J Nutr. 2009 Apr;139(4):804S-19S. Epub 2009 Feb 25.  PMID: 19244379

Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly
Plourde M, Tremblay-Mercier J, Fortier M, Pifferi F, Cunnane SC.
Nutrition. 2009 Mar;25(3):289-94. Epub 2008 Nov 26.  PMID: 19036560

PET study of 11C-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis.
Bentourkia M, Tremblay S, Pifferi F, Rousseau J, Lecomte R, Cunnane S.
Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E796-801. Epub 2009 Jan 27.  PMID: 19176356

Livres et chapitres de livre

Bégin M, Plourde M, Pifferi F, Cunnane SC. Docosahexaenoic Acid and Alzheimer's Disease: How good is the evidence? Chapter in book - New Research on Nutrition in the Prevention of Alzheimer's Disease. Eds. Ramassamy C, Bastianetto S. STM Books, invited chapter, in press.

Cunnane SC.  Human brain evolution: a question of solving the nutritional and metabolic constraints on mammalian brain development.  P. 33-64 In - Cunnane SC, Stewart K (co-editors).  Human Brain Evolution: Influences of Freshwater and Coastal Food Resources. Wiley-Blackwell, Hobokan, NJ, USA, 2010.

Cunnane SC, Stewart K. Human brain evolution: A new paradigm. Human Brain Evolution: Influences of Freshwater and Marine Food Resources. P. 203-209 in - Cunnane SC, Stewart K (co-editors). Wiley-Blackwell,, Hobokan, NJ, USA, 2010.

Stewart K, Cunnane SC, Stewart K. Human Brain Evolution: Influences of Freshwater and Marine Food Resources- and Introduction. P xiii-xix in - Cunnane SC, Stewart K (co-editors). Wiley-Blackwell, Hobokan, NJ, USA, 2010.

Bégin M, Plourde M, Pifferi F, Cunnane SC. Polyunsaturates and Brain Function During Aging. In Frontiers in Neuroscience, Eds. Montmayeur JP, LeCoutre J, Ch 19, in Fat detection: taste, texture and post-ingestive effects, CRC Press, Boca Raton, 2010.