Leon Sanche
Laboratoire Léon Sanche
Léon Sanche
Professeur titulaire
Titulaire de la Chaire de recherche du Canada en science des radiations
Université de Sherbrooke
Département de médecine nucléaire et de radiobiologie
3001, 12e avenue Nord
Sherbrooke, QC, Canada, J1H 5N4
(819) 821-8000, poste 74678
(819) 564-5442 (Télécopieur)
leon.sanche@USherbrooke.ca Thèmes de recherche
Informations supplémentaires concernant notre programme de recherche. Publications récentes “Method to measure the absolute mass of desorbed products from biomolecules in vacuum” (en préparation)
P.O. Lahaie, A. Bass, M. Huels & L. Sanche. “Effectiveness of combining gold nanoparticles with Pt-chemotherapeutic agents in the chemoradiation treatment of colorectal tumors in nude mice” (en préparation)
G. Charest, B. Paquette & L. Sanche. Development and optimization of an injectable formulation of copper diethyldithiocarbamate and its potential use for treatment of cancer (in press) Moe Wehbe, Malathi Anantha, Minghan Shi, Ada Leung, Wieslawa H. Dragowska, Léon Sanche and Marcel Bally “Tuning the Radical-Mediated Chemistry of Water with Femtosecond Laser-Induced Low Density Plasma in Aqueous Solutions” (soumis)
Hakim Belmouaddine, Minghan Shi, Léon Sanche and Daniel Houde. “Convection-enhanced delivery of liposomal formulation of carboplatin significantly increased median survival of F98 glioma bearing rats”
(Soumis).
M. Shi, MD, M. Anantha, PhD, M. Bally, PhD, D. Fortin, MD, B. Paquette, PhD & L. Sanche, PhD “Synthesis of complex organic molecules in simulated interstellar ices”
(Soumis).
S. Esmaili, A.D. Bass, P. Cloutier, L. Sanche, and M. A. Huels “Dense Ionization and Subsequent Non-Homogeneous Radical-Mediated Chemistry of Femtosecond Laser-Induced Low Density Plasma in Aqueous Solutions: Synthesis of Colloidal Gold.”
Physical Chemistry Chemical Physics. 19, 7897-7909 (2017)
Hakim Belmouaddine, Minghan Shi, Paul-Ludovic Karsenti, Ridthee Meesat, Léon Sanche and Daniel Houde. “Low-energy electron-induced dissociation in condensed-phase L-cysteine II: a comparative study on anion desorption from chemisorbedand physisorbed films.”
Eur. Phys. D.70: 75. (2016)
Elahe Alizadeh, Sylvain Massey, Léon Sanche and Paul A. Rowntree. “Absolute cross sections for electronic excitation of condensed tetrahydrofuran (THF) by 11-16 eV electrons.”
Journal of Chemical Physics J. Chem. Phys.145(17): 174703 (2016).
V. Lemelin, A. Bass, P. Cloutier and L. Sanche. “Base release and modification in solid-phase DNA exposed to low-energy electrons.” Radiation Research Radiation Research, 186(5): 520-530 (2016). S. Choofong, P. Cloutier, L. Sanche, J. R. Wagner “Increased radio-sensitivity of colorectal tumor with intra-tumoral injection of low dose of gold nanoparticles.”
International Journal of Nanomedicine 11, 5323–5333 (2016).
M. Shi, B. Paquette, T. Thippayamontri, L. Gendron, B. Guérin & L. Sanche “Interaction of low energy electrons with DNA: Applications to cancer radiation therapy”
Radiation Physics and Chemistry 128, 36-43 (2016).
L. Sanche. “Low-energy electron-induced dissociation in condensed-phase L-cysteine II: a comparative study on anion desorption from chemisorbed and physisorbed films”
The European Physical Journal D 70, 75-80 (2016).
E. Alizadeh, S. Massey, L. Sanche, and P.A. Rowntree. “Convection-enhancement delivery of liposomal formulation of oxaliplatin (LipoxalTM) shows less toxicity yet maintains a similar median survival time in F98 glioma-bearing rat model”
Invest New Drugs 34, 269–276 (2016).
M. Shi, D Fortin, B Paquette & L. Sanche “Absolute vibrational cross sections for 1-19 eV electron scattering from condensed THF”
J. Chem. Phys. 144(7): 074701 (2016)
V. Lemelin, A.D. Bass, P.Cloutier and L. Sanche “On the possibility of using low-energy electron stimulated desorption of ions as a surface probe: Analysis of Au substrates.”
International Journal of Mass Spectrometry 394, 33-41(2016).
S. Massey, E. Alizadeh , P. A. Rowntree & L. Sanche “Low-energy Electron-induced Dissociation in Condensed-phase L-cysteine I: Desorption of Anions from Chemisorbed Films.”
Journal of Physics 635, 012001-8 (2015).
E. Alizadeh, S. Massey, L. Sanche & P. A. Rowntree. “Absolute vibrational cross sections for low energy electron (1-19 eV) scattering from condensed tetrahydrofuran (THF)”
Journal of Physics 635, 062013, (2015)
V. Lemelin, L. Sanche, E.Alizadeh & P. Cloutier “Cancer treatment: Low-energy electron therapy.”
Nature Materials, 14, 861–863 (2015)
L. Sanche “Electron induced degradation of condensed Fe (CO)5 studied by electron stimulated desorption.”
Journal of Physics 635, 062012 (2015)
S. Massey, A. D. Bass, E. Alizadeh & L. Sanche “Electron Resonance Decay into a Biological Function: Decrease in Viability of E. coli Transformed by Plasmid DNA Irradiated with 0.5−18 eV Electrons.” Journal of Physical Chemistry Letters, 6, 3911−3914 (2015)
S. Kouass Sahbani, P. Cloutier, A. D. Bass, D. J. Hunting, & L. Sanche “Radiosentization of DNA by Cisplatin Adducts Results from an Increase in the Rate Constant for the Reaction with Hydrated Electrons and Formation of PtI.” Journal of Physical Chemistry B 119 (30), 9496-9500 (2015)
B. Behmand, J.-L. Marignier, M. Mostafavi, J. R. Wagner, D. J. Hunting & L. Sanche “Rare reaction channels in real-time time-dependent density functional theory: the test case of electron attachment.”
European Physical Journal D 69, 195-203 (2015)
L. Lacombe, P. Huong Mai Dinh, P.-G. Reinhard, E. Suraud & L. Sanche “Role of Low-Energy Electrons (<35 eV) in the Degradation of Fe(CO)5 for Focused Electron Beam Induced Deposition Applications: Study by Electron Stimulated Desorption of Negative and Positive Ions.”
Journal of Physical Chemistry C 119, 12708−12719 (2015)
S. Massey, A. D. Bass & L. Sanche “Low-energy Electrons Interactions with Chemisorbed and Physisorbed Films of L-cysteine/Au (111)”
Journal of Physics 635, 062008 (2015)
E. Alizadeh, S. Massey, L. Sanche & P. A. Rowntree. Loss of cellular transformation efficiency induced by DNA irradiation with low-energy (10 eV) electrons. The Journal of Physical Chemistry B 118(46), 13123-13131. (2015)
S. Kouass Sahbani, L. Sanche, P. Cloutier, A. Bass & D.J. Hunting. Convection-enhancement delivery of platinum-based drugs and LipoplatinTM to optimize the concomitant effect with radiotherapy in F98 glioma rat model.
Invest New Drugs 33,555–563 (2015).
M. Shi, D. Fortin, L.Sanche & B. Paquette Biomolecular damage induced by ionizing radiation: the direct and indirect effects of low-energy electrons on DNA. Annual Review of Physical Chemistry, 66, 379-398 (2015).
E. Alizadeh, T. Orlando & L. Sanche New therapeutic possibilities of combined treatment of radiotherapy with oxaliplatin and its liposomal formulations Lipoxal™ in rectal cancer using nude mouse xenograft.
Anticancer Research 34(10), 5303-5312 (2014).
T. Tippayamontri, R. Kotb, L. Sanche & B. Paquette. Dynamics of dissociative electron-molecule interactions in condensed methanol.
J. Phys. Chem. C 118, 22592-22600 (2014)
M. C. Boyer, M. D. Boamah, K. K. Sullivan, C. R. Arumainayagam, M.M. Bazin,
A. D. Bass & L. Sanche. “Correlation between energy deposition and molecular damage from Auger electrons: A case study of ultra-low energy (5–18 eV) electron interactions with DNA”
Medical Physics. 41, 072502-1-8 (2014)
M. Rezaee, D. J. Hunting & L. Sanche. Non-DSB clustered DNA lesions induced by ionizing radiation are largely responsible for the loss of plasmid DNA functionality in the presence of cisplatin.
Chemico-Biological Interactions. 217, 9-18 (2014)
S. Kouass Sahbani, M. Rezaee, P. Cloutier, L. Sanche and D.J. Hunting Optimal timing in concomitant chemoradiation therapy of colorectal tumors in nude mouse treated with Cisplatin and LipoplatinTM.
World Biomedical Frontiers ISSN: 2328-0166 (2014)
T. Tippayamontri, R. Kotb, B. Paquette & L. Sanche. Thymidine decomposition induced by low-energy electrons and soft X-rays under N2 and O2 atmospheres. Radiation Research. 181, 629-640 (2014)
E. Alizadeh, A.G. Sanz, G.S. Madugundu, G. Garcia, J.R. Wagner & L. Sanche. Cisplatin Intrastrand Adducts Sentitize DNA to Base Damage by Hydrated Electrons
The Journal of Physical Chemistry B. 118, 4803-4808 (2014)
B. Behmand, J.R. Wagner, L. Sanche & D.J. Hunting. The relative contributions of DNA strand breaks, base damage and clustered lesions to the loss of DNA functionality induced by ionizing radiation.
Radiation Research 181, 99-110 (2014).
S. Sahbani, S. Girouard, P. Cloutier, D.J. Hunting & L. Sanche. Low-energy-electron interactions with DNA: Approaching cellular conditions with atmospheric experiments. European Physical Journal D. 68, 40775-1-5 (2014)
E. Alizadeh & L. Sanche A single subexcitation-energy electron can induce a double strand break in DNA modified by platinum chemotherapeutic drugs.
Chem. Med. Chem. 9, 1145-1149 (2014).
M. Rezaee, E. Alizadeh, P. Cloutier, D.J. Hunting & L. Sanche. Absolute measurement of low energy electron-induced strand-break damage in films of plasmid DNA and plasmid DNA/Dap2+ complexes.
Journal of Physics 488, 052030 (2014)
O. Boulanouar, M. Rezaee, M. Fromm, P. Cloutier, Y. Zheng, A.D. Bass, M. Michaud, D.J. Hunting & L. Sanche. Hydrated electrons react with high specificity with Cisplatin bound to single-stranded DNA. The Journal of Physical Chemistry B. 117, 15944-15999 (2013)
B. Behmand, P. Cloutier, S. Girouard, J.R. Wagner, L. Sanche & D.J. Hunting. Optimization of the route of platinum drugs administration to optimize the concomitant treatment with radiotherapy for gioblastoma implanted in the Fischer rat brain.
Journal of Neurooncology 115, 365-73 (2013).
G. Charest, L. Sanche, D. Fortin, D. Mathieu & B. Paquette. Absolute cross section for loss of supercoiled topology induced by 10 eV electrons in highly uniform ∕DNA∕1, 3-diaminopropane films deposited on highly ordered pyrolitic graphite. Journal of Chemical Physics 139, 055104-7 (2013).
O. Boulanouar, M. Fromm, A.D. Bass, P. Cloutier & L. Sanche. Dissociative electron attachment to DNA-diamine thin films: Impact of the DNA close environment on the OH¯ and O¯ decay channels.
Journal of Chemical Physics 139, 055101-8 (2013).
O. Boulanouar, M. Fromm, C. Mavon, P. Cloutier & L. Sanche. New Insights into the Mechanism Underlying the Synergistic Action of Ionizing Radiation with Platinum Chemotherapeutic Drugs: The Role of Low-Energy Electrons.
International Journal of Radiation Oncology Biology Physics 87, 847-53 (2013).
M. Rezaee, D.J. Hunting & L. Sanche. Side-by-Side Comparison of DNA Damage Induced by Low-Energy Electrons and High-Energy Photons with Solid TpTpT Trinucleotide.
Journal of Physical Chemistry B 117, 10122-10131 (2013).
Y. Park, A.R. Peoples, G.S Madugundu, L. Sanche & J.R.Wagner. Note: Transient negative ions as initiators of oxygen fixation in <20 eV electron-irradiated DNA. Journal of Chemical Physics 139, 186101-2 (2013).
S. Massey, A.D. Bass & L. Sanche. Role of Humidity and Oxygen Level on Damage to DNA Induced by Soft X-rays and Low-Energy Electrons. Journal of Physical Chemistry C 117, 22445–22453 (2013).
E. Alizadeh & L. Sanche. Nanodosimetry of Auger electrons: A case study from the decay of 125I and 0–18-eV electron stopping cross sections of cytosine Physical Review E 87, 032701-4 (2013).
M. Michaud, M. Bazin & L. Sanche. Efficacy of Cisplatin and Lipoplatin™ in combined treatment with radiation of a colorectal tumor in nude mouse. Anticancer Research 33, 3005-3014 (2013).
T. Tippayamontria, R. Kotb, B. Paquette & L. Sanche Radiation Damage to DNA: The Indirect Effect of Low-Energy Electrons
Journal of Physical Chemistry Letters 4, 820-825 (2013).
E. Alizadeh, A. G. Sanz, G. García & L. Sanche. Oxygen Attachment on Alkanethiolate SAMs Induced by Low-Energy Electron Irradiation. Langmuir 29, 5222-5229 (2013).
S. Massey, A. Bass, M. Steffenhagen & L. Sanche. Cisplatin enhances the formation of DNA single and double strand breaks by hydrated electrons and hydroxyl radicals.
Radiation Research 179, 323-331 (2013).
M. Rezaee, L. Sanche & D.J. Hunting. Synergism in Concomitant Chemoradiotherapy of Cisplatin and Oxaliplatin and their Liposomal Formulation in the Human Colorectal Cancer HCT116 Model.
Anticancer Research 32, 4395-404 (2012).
T. Tippayamontria, R. Kotb, B. Paquette & L. Sanche. Radiation-Induced Formation of 2′,3′-Dideoxyribonucleosides in DNA: A Potential Signature of Low-Energy Electrons.
Journal of the American Chemical Society 134, 17366-8 (2012).
G. Madugundu, Y. Park, L. Sanche & J.R. Wagner. Absolute cross section for low energy electron damage to condensed macromolecules: A case study of DNA. Physical Review E 86, 031913 (2012).
M. Rezaee, P. Cloutier, A.D. Bass, D.J. Hunting & L. Sanche. Absolute cross sections for vibrational excitations of cytosine by low energy electron impact. Journal of Chemical Physics 137, 115103 (2012).
M. Michaud, M. Bazin & L. Sanche. Fundamental Mechanisms of DNA Radiosensitization: Damage Induced by Low-Energy Electrons in Brominated Oligonucleotide Trimers.
Journal of Physical Chemistry B 116, 9676-82 (2012).
Y. Park, K. Polska, J. Rak, J.R. Wagner & L. Sanche. Precursors of solvated electrons in radiation biology.
Chemical Reviews 112, 5578-5602 (2012).
E. Alizadeh & L. Sanche. Low energy electron stimulated desorption from DNA films dosed with oxygen.
Journal of Chemical Physics, 136, 235104 (2012).
N. Mirsaleh Kohan, A.D. Bass, P. Cloutier, S. Massey & L. Sanche. Electron simulated desorption of anions from native and brominated single stranded oligonucleotide trimers. Journal of Chemical Physics 136, 075101 (2012).
K. Polska, J. Rak, A.D. Bass, P. Cloutier & L. Sanche. Glioblastoma treatment: Bypassing the toxicity of platinum compounds by using liposomal formulation and increasing treatment efficiency with concomitant radiotherapy.
International Journal of Radiation Oncology, Biology, Physics 84, 244-249 (2012).
G. Charest, B. Paquette, L. Sanche, D. Fortin & D. Mathieu. Induction of Strand Breaks in DNA films by Low Energy Electrons and Soft X-ray under Nitrous Oxide Atmosphere. Radiation Physics and Chemistry 81, 33-39 (2012).
E. Alizadeh & L. Sanche. DNA-Platinum Thin Films for Use in Chemoradiation Therapy Studies,
Bioinorganic Chemistry and Applications 2012, 923914-1-9 (2012).
M. Rezaee, E. Alizadeh, D. Hunting & L. Sanche. Measurement of inelastic cross sections for low-energy electron scattering from DNA bases. International Journal of Radiation Biology 88, 15-21 (2012).
M. Michaud, M. Bazin & L. Sanche. Measurements of G-values for DNA Damage Induced by Low Energy Electrons.
The Journal of Physical Chemistry B 115, 14852–14858 (2011).
E. Alizadeh & L. Sanche. Energy Dependence of Gold Nanoparticle Radio-Sensitisation in Plasmid DNA.
Journal of Physical Chemistry C 115, 20160–20167 (2011).
S. McMahon, W. Hyland, E. Brun, K. Butterworth, J. Coulter, T. Douki, D. Hirst, S. Jain, A. Kavanagh, Z. Krpetic, M. Mendenhall, M. Muir, K. Prise, H. Requardt, L. Sanche, G. Schettino, F. Currell & C. Sicard-Roselli. Soft adsorption of densely packed multi-layer of DNA-plasmid • 1, 3-diaminopropane complexes onto highly oriented pyrolitic graphite designed to erode in water.
Journal of Physical Chemistry C 115, 21291-21298 (2011).
O. Boulamouar, A. Khatyr, G. Herlem, F. Palmino, L. Sanche & M. Fromm. Low energy electron induced DNA damage in a trinucleotide containing 5-bromouracil.
Journal of Physical Chemistry B 115, 13668–13673 (2011).
Z. Li, P. Cloutier, L. Sanche & J.R. Wagner. Soft X-ray and LEE induced damage to DNA in N2 and O2 atmospheres.
The Journal of Physical Chemistry B 115, 4523-4531 (2011).
E. Alizadeh, P. Cloutier, D. Hunting & L. Sanche. DNA damage induced by low energy electrons: Conversion of thymine to
5, 6-dihydrothymine in the oligonucleotide trimer TpTpT.
Radiation Research 175, 240-246 (2011).
Y. Park, Z. Li, P. Cloutier, L. Sanche & J.R. Wagner. Effect of morphology of thin DNA films on the electron stimulated desorption of anions. The Journal of Chemical Physics 134, 015102 (2011).
N. Mirsaleh-Kohan, A.D. Bass & L. Sanche. Cellular uptake and cytoplasm/DNA distribution of liposomal formulation of cisplatin and oxaliplatin in human colorectal cancer cell HCT116.
Invest New Drugs 29, 1321–1327 (2011).
T. Tippayamontri, R. Kobt, B. Paquette & L. Sanche. Absolute cross sections for electronic excitations of cytosine by low energy electron impact. Journal of Chemical Physics 133, 155104 (2010).
M. Bazin, M. Michaud & L. Sanche. “Damage to amino acid-nucleotide pairs induced by 1 eV electrons.
Physical Chemistry Chemical Physics 12, 9367-9372 (2010).
S. Ptasińska, Z. Li, N.J. Mason & L. Sanche. Electron Stimulated Desorption of anions and cations from condensed allyl-glycidyl ether”. Physical Chemistry Chemical Physics 12, 7950-8 (2010).
Y. Yildirim, M. Balcan A.D. Bass, P. Cloutier & L. Sanche. Preferential tumor accumulation of gold nanoparticles, visualized by magnetic resonance imaging: radiosensitization studies in vivo and in vitro.
International Journal of Radiation Biology 86, 692-700 (2010).
E. Hébert, P.-J. Debouttière, M. Lepage, L. Sanche & D.J. Hunting. Low Energy Electron Induced DNA Damage: Effect of Base Sequence in Oligonucleotide Trimers.
Journal of the American Chemical Society 132, 5422–5427 (2010).
Z. Li, P. Cloutier, L. Sanche & J.R. Wagner. XPS analysis of gold surfaces after removal of thiolated DNA oligomers by UV/ozone treatment. Langmuir 26, 6508–6514 (2010).
N. Mirsaleh-Kohan, A.D. Bass & L. Sanche. Electron induced dissociation in the condensed-phase nitromethane: II Desorption of neutral fragments. Journal of Physics Condensed Matter 22, 084003 (2010).
M. Bazin, S. Ptasińska, A.D. Bass, L. Sanche, E. Burean & P. Swiderek. Electron Stimulated Desorption of Anions Containing Oxygen and Nitrogen from Self-Assembled Monolayers of DNA.
Journal of Physics: Conference Series 204, 012005 (2010).
N. Mirsaleh-Kohan, A.D. Bass, P. Cloutier & L. Sanche. Concomittant treatment of F98 glioma cells with new liposomal compounds and ionizing radiation. Journal of Neuro-Oncology 97, 187–193 (2010).
G. Charest, B. Paquette, D. Fortin, D. Mathieu & L. Sanche. Low-energy electrons and X-ray irradiation effects on plasma-polymerized allylamine bioactive coatings for stents. Polymer Degradation and Stability 95, 153-163 (2010).
S. Massey, E. Gallino, P. Cloutier, M. Tatoulian, L. Sanche, D. Mantovani & D. Roy. Protection by organic ions against DNA damage induced by low energy electrons .
Journal of Chemical Physics 132, 045102 (2010).
A. Dumont, Y. Zheng, D. Hunting & L. Sanche. Biological chemistry: Beyond radical thinking.
Nature 461, 358-359 (2009).
L. Sanche. Low-energy electron scattering from DNA including structural water and base-pair irregularities. Physical Review A 80, 012705-1-6 (2009).
L. Caron, L. Sanche, S. Tonzani & C.H. Greene. Damage Induced to DNA by Low-Energy (0-30 eV) Electrons under Vacuum and Atmospheric Conditions. Journal of Physical Chemistry B 113, 10008–10013 (2009).
E. Brun, P. Cloutier, C. Sicard-Roselli, M. Fromm & L. Sanche. Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution”.
Colloids Surface B Biointerfaces 72, 128–134 (2009).
E. Brun, L. Sanche & C. Sicard-Roselli. Polymer gel in rat skull to assess the accuracy of a new rat stereotactic device for use with the Gamma Knife. Acta Neurochirurgica 151, 677–684 (2009).
G. Charest, D. Mathieu, M. Lepage, D. Fortin, B. Paquette & L. Sanche. Gold nanoparticles enhanceDNA damage induced by anti-cancer drugs and radiation.
Radiation Research, 172, 114-119 (2009).
Y. Zheng & L. Sanche. “Role of secondary low energy electrons in radiobiology and chemoradiation therapy of cancer”. Chemical Physics Letters 474, 1-6 (2009).
L. Sanche. Electron induced dissociation in the condensed-phase nitromethane: I. Desorption of ionic fragments. Physical Chemistry Chemical Physics 11, 1610-8 (2009).
M. Bazin, S. Ptasińska, A.D. Bass & L. Sanche. Gold nanoparticles enhance the X-ray-induced degradation of human centrin 2 protein.
Radiation Physics and Chemistry 78, 177–183 (2009)
E. Brun, P. Duchambon, Y. Blouquit, G. Keller, L. Sanche & C. Sicard-Roselli. Radiosensitization by gold nanoparticles: Comparison of DNA damage induced by low and high-energy electrons. Journal of Biomedical Nanotechnology 4, 469-481 (2008).
Y. Zheng, P. Cloutier, D.J. Hunting & L. Sanche. Chemical synthesis induced by dissociative electron attachment.
Journal of Physical Chemistry C 112, 17319-17326 (2008).
M. Rajappan, L. Zhu, A. Bass, L. Sanche & C. Arumainayagam. Diffraction in low-energy electron scattering from DNA: bridging gas phase and solid state theory. Physical Review A 78, 042710 (2008).
L.G. Caron, S. Tonzani, C.H. Greene & L. Sanche. Revisiting the electron stimulated desorption of anions from thin films of CF2CL2.
International Journal of Mass Spectrometry 277, 251-255 (2008).
A.D. Bass, C.R. Arumainayagam & L. Sanche. Small steps on the slippery road to life: Molecular synthesis in astrophysical ices initiated by low energy electron impact.
International Journal of Mass Spectrometry 277, 256–261 (2008).
M.A. Huels, L. Parenteau, A.D. Bass & L. Sanche. DNA damage by X-ray and low energy electron beam irradiation.
Journal of Radiation Protection, 23, 53-59 (2008).
Y.S. Park, Y.A. Noh, H. Cho, A. Dumont, S. Ptasińska, A.D. Bass & L. Sanche. X-ray induced damage in DNA monitored by X-ray photoelectron spectroscopy.
Journal of Chemical Physics, 129, 065102 (2008).
S. Ptasińska, A. Stypczyńska, T.Nixon, N.J. Mason, D.V. Klyachko & L. Sanche. Electron transfer reactions for image and image-derived states in dielectric thin films.
Journal of Chemical Physics, 129, 074703-1-9 (2008).
E.T. Jensen & L. Sanche. Low energy electron attachment to condensed formic acid
Journal of Physics Conference Series 115,012018-1-8 (2008).
S. Ptasińska, A.D. Bass & L. Sanche. Mass spectrometry investigation of the degradation of polyethylene terephtalate induced by low-energy (<100 eV) electrons.
Radiation Physics and Chemistry 77, 889–897 (2008).
S. Massey, P. Cloutier, L. Sanche & D. Roy. Role of secondary low-energy electrons in the concomitant chemoradiation therapy of cancer. Physical Review Letters 100, 198101 (2008).
Y. Zheng, D.J. Hunting, P. Ayotte, and L. Sanche. Low Energy Electron Induced DNA Damage: Effects of Terminal Phosphate and Base Moieties on the Distribution of Damage.
Journal of the American Chemical Society 130, 5612–5613 (2008).
Z. Li, Y. Zheng, P. Cloutier, L. Sanche & J.R. Wagner. Chemical modication of polystyrene by low-energy (<100 eV) electron irradiation studied by mass spectrometry.
Journal of Applied Polymer Science 108, 3163–3168 (2008).
S. Massey, P. Cloutier, M. Bazin, L. Sanche & D. Roy. Multiple scattering approach to elastic low-energy electron collisions with the water dimer. Journal of Physics B: Atomic, Molecular and Optical Physics 41, 045204 (2008).
D. Bouchiha, L.G. Caron, J.D. Gorfinkiel & L. Sanche. Low-energy electron and X-ray degradation of biomedical plasma-fluoropolymer
Polymer Degradation and Stability 93, 383-391 (2008).
S. Massey, P. Cloutier, P. Hale, M. Bazin, L. Sanche D. Mantovani & D. Roy. TDAB-induced DNA plasmid condensation on the surface of a reconstructed boron doped silicon substrate Surface Science 602, 142-150 (2008).
A. Mougin, V.G. Babak, F. Palmino, E. Bêche, F. Baros, D.J. Hunting, L. Sanche &
M. Fromm. Radiosensitization of DNA by gold nanoparticles irradiated with high energy electrons
Radiation Research 169, 19-27 (2008).
Y. Zheng, D.J. Hunting, P. Ayotte & L. Sanche. “From DNA to nucleic bases - the effects of low-energy electron impact”
Journal of Physics: Conference Series 88, 012074-1-8 (2007).
R. Panajotovic, M. Michaud & L. Sanche. Low-energy electron induced processes in fluorinated copper phthalocyanine films observed by F-desorption: Why so little damage.
Journal of Physical Chemistry 111, 12427-12433 (2007).
D. Menzel, P. Cloutier, L. Sanche & T.E. Madey. Adapting gas phase electron scattering R-matrix calculations to a condensed matter environment Physical Review A 76, 032716-1-7 (2007).
L. Caron, D. Bouchiha, J.D. Gorfinkiel & L. Sanche. Elastic scattering of electrons and positrons.
Journal of the International Commission on Radiation Unit, ICRU Report 77, ISSN 1473-6691, 7, 1-151 (2007).
L. Sanche et al. Low-energy electron transmission through thin-film molecular and biomolecular solids.
Chemical Reviews 107, 1553-1579 (2007).
R. Naaman & L. Sanche. Low energy electron stimulated desorption of ions from whole human blood.
International Journal of Mass Spectrometry 263, 179–184 (2007).
S. Ptasińska & L. Sanche. Dissociative electron attachment to abasic DNA.
Physical Chemistry Chemical Physics 9, 1730-1735 (2007).
S. Ptasińska & L. Sanche. Dissociative electron attachment to hydrated single DNA strands.
Physical Review E 75, 031915-1-5 (2007)
S. Ptasińska & L. Sanche. Low-energy electron collisions with methanol.
Journal of Physics B: Atomic, Molecular and Optical Physics 40 1259–1270 (2007).
D. Bouchiha, J.D. Gorfinkiel, L.G. Caron & L. Sanche. Low-energy (3-24 eV) electron damage to the peptide backbone.
The Journal of Physical Chemistry B 111, 1620-1624 (2007).
P. Cloutier, C. Sicard-Roselli, E. Escher & L. Sanche. Cross sections for low-energy electron scattering from adenine in the condensed phase.
Physical Chemistry Chemical Physics 9, 138-48 (2007).
R. Panajotović, M. Michaud & L. Sanche. Electron photoemission from charged films: Absolute cross section for trapping 0-5 eV electrons in condensed CO2. The Journal of Chemical Physics 126, 024701 (2007).
M. Michaud, E.M. Hébert, P. Cloutier & L. Sanche. On the mechanism of anion desorption from DNA induced by low energy electrons.
The Journal of Chemical Physics 125, 144713 (2006).
S. Ptasinska & L. Sanche. Absolute cross section for trapping low-energy electrons (0-18 eV) in molecular films of n-hexane. Journal of Applied Physics 100, 073705-1-9 (2006).
M. Michaud, E. Hébert, P. Cloutier & L. Sanche. Electron stimulated desorption of anionic fragments from films of pure and electron-irradiated thiophene. Journal of Chemical Physics 125, 094704-1-12 (2006).
M.N. Hedhilli, P. Cloutier, A.D. Bass, T.E. Madey & L. Sanche. Cross sections for electron trapping by DNA and its component subunits I: Condensed tetrahydrofuran deposited on Kr. The Journal of Chemical Physics 125, 074714 (2006).
Y.S. Park, H. Cho, L. Parenteau, A.D. Bass & L. Sanche. Products and reaction sequences in tetrahydrofuran exposed to low-energy electrons.
Journal of Physical Chemistry B, 110, 12512-22 (2006).
C. Jäggle, P. Swiderek, S.-Ph. Breton, M. Michaud & L. Sanche. Temporary electron localization and scattering in disordered single-strands of DNA.
Physical Review A, 73, 062707-1-062707-7 (2006).
L.G. Caron & L. Sanche. Base Release in Nucleosides Induced by Low-Energy Electrons: A DFT Study
Radiation Research, 165, 721-729 (2006).
X. Li, L. Sanche & M.D. Sevilla. DNA damage induced by low energy electrons: electron transfer and diffraction.
Physical Review Letters 96, 208101-1-208101-4 (2006).
Y. Zheng, R. Wagner & L. Sanche. Dissociative electron attachment to DNA basic constituents: the phosphate group.
Chemical Physics Letters, 421, 404-408 (2006).
X. Pan & L. Sanche. Effective cross sections for single strand break production in plasmid DNA by 0.1 to 4.7 eV electrons. Radiation Research 165, 452-459 (2006).
R. Panajotovic, F. Martin, P. Cloutier, D.J. Hunting & L. Sanche Phosphodiester and N-glycosidic bond cleavage in DNA induced by 4-15 eV electrons.
Journal of Chemical Physics, 124, 064710-1-9 (2006).
Y. Zheng, P. Cloutier, D.J. Hunting, J.R. Wagner & L. Sanche. Enhanced DNA damage induced by secondary electron emission from a tantalum surface exposed to soft X-rays. Radiation Research, 165, 365-371(2006).
Z.Cai, P. Cloutier, D. Hunting & L. Sanche. Induction of strand breaks by low energy electrons (8-68 eV) in a self-assembled monolayer of oligonucleotides: Effective cross-sections and attenuation lengths.
Journal of Chemical Physics, 124, 024705-1-5 (2006).
Z. Cai, M.-E. Dextraze, P. Cloutier, D. Hunting & L. Sanche. Low energy electron collisions with tetrahydrofuran.
J. Phys. B: At. Mol. Op. Phys., 39, 975-986 (2006).
D. Bouchiha, J.D. Gorfinkiel, L.G. Caron &L. Sanche. Interstrand cross-link induction by UV radiation in bromodeoxyuridine substituted DNA: dependence on DNA conformation. Biochemistry, 44, 16957-16966 (2005).
S. Cecchini, C. Masson, C. La Madeleine, M.A. Huels, L. Sanche & D.J. Hunting. Chemical basis of DNA sugar-phosphate cleavage by low-energy electrons.
Journal of the American Chemical Society, 127, 16592-16598 (2005).
Y. Zheng, P. Cloutier, D.J. Hunting, L. Sanche & J.R. Wagner. Double sublimation system to deposit molecules from solid organic compounds onto a cryogenic substrate: Thymine on solid argon.
Review of Scientific Instruments, 76, 103901-103906 (2005).
P. Lévesque, M. Michaud & L. Sanche. Diffraction in resonant electron scattering from helical macromolecules: Effects of the DNA backbone. Physical Review A, 72, 032726-1-6 (2005).
L. Caron & L. Sanche. Low energy electron-driven damage in biomolecules.
European Physics Journal D – Atom., Mol. Opt. Phys., 35, 367-390 (2005).
L. Sanche. Response to Dr. Ward's comments on sensitization of single stranded DNA.
Radiation Reseach, 164, 342 (2005).
S. Cecchini, S. Girouard, M.A. Huels, L. Sanche & D.J. Hunting. Low energy electron and O¯ reactions in films of O2 coadsorbed with benzene or toluene. Physical Chemistry Chemical Physics, 7, 3359-5567 (2005).
M. Imhoff, L. Parenteau, L. Sanche & M.A. Huels. Absolute electronic excitation cross sections for low-energy electron (5-12 eV) scattering from condensed thymine.
Journal of Chemical Physics, 122, 224704-1-7 (2005).
P.L. Lévesque, M. Michaud, W. Cho & L. Sanche. Mechanism and site of attack for direct damage to DNA by low-energy electrons.
Physical Review Letters, 94, 198104-1-4 (2005).
X. Pan & L. Sanche. Electron attachment in ice-HCl clusters: An Ab Initio study.
Journal of Physical Chemistry, 109, 4591-4600 (2005).
X. Li, L. Sanche, A. Rauk & D. Armstrong. Interstrand cross-links: a new type of gamma ray damage in bromodeoxyuridine substituted DNA. Biochemistry, 44, 1932-1940 (2005).
S. Cecchini, S. Girouard, M.A. Huels, L. Sanche & D.J. Hunting. Comparison between X-ray photon and secondary electron damage to DNA in vacuum.
Journal of Physical Chemistry B, 109, 4796-4800 (2005).
Z. Cai, P. Cloutier, D. Hunting & L. Sanche. Absolute vibrational and electronic cross sections for low-energy electron (2-12 eV) scattering from condensed pyrimidines.
Journal of Chemical Physics, 122, 094701-1-095701-10 (2005).
P.L. Lévesque, M. Michaud & L. Sanche. Cross sections for electron scattering from selected components of DNA and RNA.
Radiation Physics and Chemistry, 73, 74-84 (2005).
P. Mozejko & L. Sanche. DNA inter-duplex crosslinks induced by AlKa X-rays under vacuum.
Radiation Research, 164, 173-179 (2005).
Z. Cai, P. Cloutier, L. Sanche & D. Hunting. D¯, O¯ and OD¯ desorption induced by low-energy (0-20 eV) electron impact on amorphous D2O films. Radiation Physics and Chemistry, 72, 193-199 (2005).
X. Pan, H. Abdoul-Carime, P. Cloutier, A.D. Bass & L. Sanche. Publications représentatives Resonant formation of DNA strand breaks by low energy (3-20 eV) electrons. Science 287, 1658-1660 (2000). B. Boudaiffa, P. Cloutier, D. Hunting, M.A. Huels & L. Sanche. Cross sections for low-energy (1-100 eV) electron elastic and inelastic scattering in amorphous ice. Radiation Research, 159, 3-22 (2003). M. Michaud, A. Wen & L. Sanche. Dissociative electron attachment to DNA. Physical Review Letters, 90, 208102-1-208102-4 (2003). X. Pan, P. Cloutier, D. Hunting & L. Sanche. Density functional theory studies of electron interaction with DNA: Can zero eV electrons induce strand breaks? Journal of the American Chemical Society, 125, 13668-13669 (2003). X.F. Li, M.D. Sevilla & L. Sanche. DNA strand breaks induced by 0-4 eV electrons: the role of shape resonances. Physical Review Letters, 93, 068101-1-4 (2004). F. Martin, P.D. Burrow, Z. Cai, P. Cloutier, D.J. Hunting & L. Sanche. Low energy electron attachment to condensed formic acid Journal of Physics Conference Series 115, 012018-1-8 (2008).S. Ptasińska, A.D. Bass & L. Sanche. Gold nanoparticles enhance DNA damage induced by anti-cancer drugs and radiation. Radiation Research, 172, 114-119 (2009). Y. Zheng & L. Sanche. Biological chemistry: Beyond radical thinking.Nature 461, 358-359 (2009). L. Sanche. Low Energy Electron Induced DNA Damage: Effect of Base Sequence in Oligonucleotide Trimers. Journal of the American Chemical Society 132, 5422–5427 (2010). Z. Li, P. Cloutier, L. Sanche & J.R. Wagner. On the role of low-energy electrons in the radiosensitization of DNA by gold nanoparticles. Nanotechnology 22, 465101 (2011). F. Xiao, Y. Zheng, P. Cloutier, Y. He, D. Hunting & L. Sanche. Precursors of solvated electrons in radiation biology. Chemical Reviews 112, 5578-5602 (2012). E. Alizadeh & L. Sanche. Efficacy of Cisplatin and Lipoplatin™ in combined treatment with radiation of a colorectal tumor in nude mouse. Anticancer Research 33, 3005-3014 (2013). T. Tippayamontria, R. Kotb, B. Paquette & L. Sanche New Insights into the Mechanism Underlying the Synergistic Action of Ionizing Radiation with Platinum Chemotherapeutic Drugs: The Role of Low-Energy Electrons. International Journal of Radiation Oncology Biology Physics 87, 847-53 (2013). M. Rezaee, D.J. Hunting & L. Sanche. “Electron Resonance Decay into a Biological Function: Decrease in Viability of E. coli Transformed by Plasmid DNA Irradiated with 0.5−18 eV Electrons.” Journal of Physical Chemistry Letters, 6, 3911−3914 (2015) S. Kouass Sahbani, P. Cloutier, A. D. Bass, D. J. Hunting, & L. Sanche “Cancer treatment: Low-energy electron therapy.” Nature Materials, 14, 861–863 (2015) L. Sanche “Interaction of low energy electrons with DNA: Applications to cancer radiation therapy” Radiation Physics and Chemistry 128, 36-43 (2016). L. Sanche. Ressources
Professeur titulaire
Titulaire de la Chaire de recherche du Canada en science des radiations
Université de Sherbrooke
Département de médecine nucléaire et de radiobiologie
3001, 12e avenue Nord
Sherbrooke, QC, Canada, J1H 5N4
(819) 821-8000, poste 74678
(819) 564-5442 (Télécopieur)
leon.sanche@USherbrooke.ca Thèmes de recherche
Nos études portent sur les sujets suivant
- Les phénomènes ultrarapides en radiobiologie
- Le rôle des électrons secondaires au niveau du dommage radiobiologique et de la radiothérapie avec ou sans chimiothérapie
- L'interaction des électrons lents et secondaires avec l'ADN, les protéines, les radiosensibilisateurs et les agents chimiothérapeutiques
- Analyse des produits formés par les électrons secondaires et les électrons de faible énergie dans les systèmes d'intérêt biologique
- Mesure de sections efficaces d'interaction des électrons de faible énergie avec des molécules cellulaires pour la radiothérapie
- Applications de la physique des radiations au traitement du cancer par la radiothérapie et la thérapie combinée (radiation + chimiothérapie)
Informations supplémentaires concernant notre programme de recherche. Publications récentes “Method to measure the absolute mass of desorbed products from biomolecules in vacuum” (en préparation)
P.O. Lahaie, A. Bass, M. Huels & L. Sanche. “Effectiveness of combining gold nanoparticles with Pt-chemotherapeutic agents in the chemoradiation treatment of colorectal tumors in nude mice” (en préparation)
G. Charest, B. Paquette & L. Sanche. Development and optimization of an injectable formulation of copper diethyldithiocarbamate and its potential use for treatment of cancer (in press) Moe Wehbe, Malathi Anantha, Minghan Shi, Ada Leung, Wieslawa H. Dragowska, Léon Sanche and Marcel Bally “Tuning the Radical-Mediated Chemistry of Water with Femtosecond Laser-Induced Low Density Plasma in Aqueous Solutions” (soumis)
Hakim Belmouaddine, Minghan Shi, Léon Sanche and Daniel Houde. “Convection-enhanced delivery of liposomal formulation of carboplatin significantly increased median survival of F98 glioma bearing rats”
(Soumis).
M. Shi, MD, M. Anantha, PhD, M. Bally, PhD, D. Fortin, MD, B. Paquette, PhD & L. Sanche, PhD “Synthesis of complex organic molecules in simulated interstellar ices”
(Soumis).
S. Esmaili, A.D. Bass, P. Cloutier, L. Sanche, and M. A. Huels “Dense Ionization and Subsequent Non-Homogeneous Radical-Mediated Chemistry of Femtosecond Laser-Induced Low Density Plasma in Aqueous Solutions: Synthesis of Colloidal Gold.”
Physical Chemistry Chemical Physics. 19, 7897-7909 (2017)
Hakim Belmouaddine, Minghan Shi, Paul-Ludovic Karsenti, Ridthee Meesat, Léon Sanche and Daniel Houde. “Low-energy electron-induced dissociation in condensed-phase L-cysteine II: a comparative study on anion desorption from chemisorbedand physisorbed films.”
Eur. Phys. D.70: 75. (2016)
Elahe Alizadeh, Sylvain Massey, Léon Sanche and Paul A. Rowntree. “Absolute cross sections for electronic excitation of condensed tetrahydrofuran (THF) by 11-16 eV electrons.”
Journal of Chemical Physics J. Chem. Phys.145(17): 174703 (2016).
V. Lemelin, A. Bass, P. Cloutier and L. Sanche. “Base release and modification in solid-phase DNA exposed to low-energy electrons.” Radiation Research Radiation Research, 186(5): 520-530 (2016). S. Choofong, P. Cloutier, L. Sanche, J. R. Wagner “Increased radio-sensitivity of colorectal tumor with intra-tumoral injection of low dose of gold nanoparticles.”
International Journal of Nanomedicine 11, 5323–5333 (2016).
M. Shi, B. Paquette, T. Thippayamontri, L. Gendron, B. Guérin & L. Sanche “Interaction of low energy electrons with DNA: Applications to cancer radiation therapy”
Radiation Physics and Chemistry 128, 36-43 (2016).
L. Sanche. “Low-energy electron-induced dissociation in condensed-phase L-cysteine II: a comparative study on anion desorption from chemisorbed and physisorbed films”
The European Physical Journal D 70, 75-80 (2016).
E. Alizadeh, S. Massey, L. Sanche, and P.A. Rowntree. “Convection-enhancement delivery of liposomal formulation of oxaliplatin (LipoxalTM) shows less toxicity yet maintains a similar median survival time in F98 glioma-bearing rat model”
Invest New Drugs 34, 269–276 (2016).
M. Shi, D Fortin, B Paquette & L. Sanche “Absolute vibrational cross sections for 1-19 eV electron scattering from condensed THF”
J. Chem. Phys. 144(7): 074701 (2016)
V. Lemelin, A.D. Bass, P.Cloutier and L. Sanche “On the possibility of using low-energy electron stimulated desorption of ions as a surface probe: Analysis of Au substrates.”
International Journal of Mass Spectrometry 394, 33-41(2016).
S. Massey, E. Alizadeh , P. A. Rowntree & L. Sanche “Low-energy Electron-induced Dissociation in Condensed-phase L-cysteine I: Desorption of Anions from Chemisorbed Films.”
Journal of Physics 635, 012001-8 (2015).
E. Alizadeh, S. Massey, L. Sanche & P. A. Rowntree. “Absolute vibrational cross sections for low energy electron (1-19 eV) scattering from condensed tetrahydrofuran (THF)”
Journal of Physics 635, 062013, (2015)
V. Lemelin, L. Sanche, E.Alizadeh & P. Cloutier “Cancer treatment: Low-energy electron therapy.”
Nature Materials, 14, 861–863 (2015)
L. Sanche “Electron induced degradation of condensed Fe (CO)5 studied by electron stimulated desorption.”
Journal of Physics 635, 062012 (2015)
S. Massey, A. D. Bass, E. Alizadeh & L. Sanche “Electron Resonance Decay into a Biological Function: Decrease in Viability of E. coli Transformed by Plasmid DNA Irradiated with 0.5−18 eV Electrons.” Journal of Physical Chemistry Letters, 6, 3911−3914 (2015)
S. Kouass Sahbani, P. Cloutier, A. D. Bass, D. J. Hunting, & L. Sanche “Radiosentization of DNA by Cisplatin Adducts Results from an Increase in the Rate Constant for the Reaction with Hydrated Electrons and Formation of PtI.” Journal of Physical Chemistry B 119 (30), 9496-9500 (2015)
B. Behmand, J.-L. Marignier, M. Mostafavi, J. R. Wagner, D. J. Hunting & L. Sanche “Rare reaction channels in real-time time-dependent density functional theory: the test case of electron attachment.”
European Physical Journal D 69, 195-203 (2015)
L. Lacombe, P. Huong Mai Dinh, P.-G. Reinhard, E. Suraud & L. Sanche “Role of Low-Energy Electrons (<35 eV) in the Degradation of Fe(CO)5 for Focused Electron Beam Induced Deposition Applications: Study by Electron Stimulated Desorption of Negative and Positive Ions.”
Journal of Physical Chemistry C 119, 12708−12719 (2015)
S. Massey, A. D. Bass & L. Sanche “Low-energy Electrons Interactions with Chemisorbed and Physisorbed Films of L-cysteine/Au (111)”
Journal of Physics 635, 062008 (2015)
E. Alizadeh, S. Massey, L. Sanche & P. A. Rowntree. Loss of cellular transformation efficiency induced by DNA irradiation with low-energy (10 eV) electrons. The Journal of Physical Chemistry B 118(46), 13123-13131. (2015)
S. Kouass Sahbani, L. Sanche, P. Cloutier, A. Bass & D.J. Hunting. Convection-enhancement delivery of platinum-based drugs and LipoplatinTM to optimize the concomitant effect with radiotherapy in F98 glioma rat model.
Invest New Drugs 33,555–563 (2015).
M. Shi, D. Fortin, L.Sanche & B. Paquette Biomolecular damage induced by ionizing radiation: the direct and indirect effects of low-energy electrons on DNA. Annual Review of Physical Chemistry, 66, 379-398 (2015).
E. Alizadeh, T. Orlando & L. Sanche New therapeutic possibilities of combined treatment of radiotherapy with oxaliplatin and its liposomal formulations Lipoxal™ in rectal cancer using nude mouse xenograft.
Anticancer Research 34(10), 5303-5312 (2014).
T. Tippayamontri, R. Kotb, L. Sanche & B. Paquette. Dynamics of dissociative electron-molecule interactions in condensed methanol.
J. Phys. Chem. C 118, 22592-22600 (2014)
M. C. Boyer, M. D. Boamah, K. K. Sullivan, C. R. Arumainayagam, M.M. Bazin,
A. D. Bass & L. Sanche. “Correlation between energy deposition and molecular damage from Auger electrons: A case study of ultra-low energy (5–18 eV) electron interactions with DNA”
Medical Physics. 41, 072502-1-8 (2014)
M. Rezaee, D. J. Hunting & L. Sanche. Non-DSB clustered DNA lesions induced by ionizing radiation are largely responsible for the loss of plasmid DNA functionality in the presence of cisplatin.
Chemico-Biological Interactions. 217, 9-18 (2014)
S. Kouass Sahbani, M. Rezaee, P. Cloutier, L. Sanche and D.J. Hunting Optimal timing in concomitant chemoradiation therapy of colorectal tumors in nude mouse treated with Cisplatin and LipoplatinTM.
World Biomedical Frontiers ISSN: 2328-0166 (2014)
T. Tippayamontri, R. Kotb, B. Paquette & L. Sanche. Thymidine decomposition induced by low-energy electrons and soft X-rays under N2 and O2 atmospheres. Radiation Research. 181, 629-640 (2014)
E. Alizadeh, A.G. Sanz, G.S. Madugundu, G. Garcia, J.R. Wagner & L. Sanche. Cisplatin Intrastrand Adducts Sentitize DNA to Base Damage by Hydrated Electrons
The Journal of Physical Chemistry B. 118, 4803-4808 (2014)
B. Behmand, J.R. Wagner, L. Sanche & D.J. Hunting. The relative contributions of DNA strand breaks, base damage and clustered lesions to the loss of DNA functionality induced by ionizing radiation.
Radiation Research 181, 99-110 (2014).
S. Sahbani, S. Girouard, P. Cloutier, D.J. Hunting & L. Sanche. Low-energy-electron interactions with DNA: Approaching cellular conditions with atmospheric experiments. European Physical Journal D. 68, 40775-1-5 (2014)
E. Alizadeh & L. Sanche A single subexcitation-energy electron can induce a double strand break in DNA modified by platinum chemotherapeutic drugs.
Chem. Med. Chem. 9, 1145-1149 (2014).
M. Rezaee, E. Alizadeh, P. Cloutier, D.J. Hunting & L. Sanche. Absolute measurement of low energy electron-induced strand-break damage in films of plasmid DNA and plasmid DNA/Dap2+ complexes.
Journal of Physics 488, 052030 (2014)
O. Boulanouar, M. Rezaee, M. Fromm, P. Cloutier, Y. Zheng, A.D. Bass, M. Michaud, D.J. Hunting & L. Sanche. Hydrated electrons react with high specificity with Cisplatin bound to single-stranded DNA. The Journal of Physical Chemistry B. 117, 15944-15999 (2013)
B. Behmand, P. Cloutier, S. Girouard, J.R. Wagner, L. Sanche & D.J. Hunting. Optimization of the route of platinum drugs administration to optimize the concomitant treatment with radiotherapy for gioblastoma implanted in the Fischer rat brain.
Journal of Neurooncology 115, 365-73 (2013).
G. Charest, L. Sanche, D. Fortin, D. Mathieu & B. Paquette. Absolute cross section for loss of supercoiled topology induced by 10 eV electrons in highly uniform ∕DNA∕1, 3-diaminopropane films deposited on highly ordered pyrolitic graphite. Journal of Chemical Physics 139, 055104-7 (2013).
O. Boulanouar, M. Fromm, A.D. Bass, P. Cloutier & L. Sanche. Dissociative electron attachment to DNA-diamine thin films: Impact of the DNA close environment on the OH¯ and O¯ decay channels.
Journal of Chemical Physics 139, 055101-8 (2013).
O. Boulanouar, M. Fromm, C. Mavon, P. Cloutier & L. Sanche. New Insights into the Mechanism Underlying the Synergistic Action of Ionizing Radiation with Platinum Chemotherapeutic Drugs: The Role of Low-Energy Electrons.
International Journal of Radiation Oncology Biology Physics 87, 847-53 (2013).
M. Rezaee, D.J. Hunting & L. Sanche. Side-by-Side Comparison of DNA Damage Induced by Low-Energy Electrons and High-Energy Photons with Solid TpTpT Trinucleotide.
Journal of Physical Chemistry B 117, 10122-10131 (2013).
Y. Park, A.R. Peoples, G.S Madugundu, L. Sanche & J.R.Wagner. Note: Transient negative ions as initiators of oxygen fixation in <20 eV electron-irradiated DNA. Journal of Chemical Physics 139, 186101-2 (2013).
S. Massey, A.D. Bass & L. Sanche. Role of Humidity and Oxygen Level on Damage to DNA Induced by Soft X-rays and Low-Energy Electrons. Journal of Physical Chemistry C 117, 22445–22453 (2013).
E. Alizadeh & L. Sanche. Nanodosimetry of Auger electrons: A case study from the decay of 125I and 0–18-eV electron stopping cross sections of cytosine Physical Review E 87, 032701-4 (2013).
M. Michaud, M. Bazin & L. Sanche. Efficacy of Cisplatin and Lipoplatin™ in combined treatment with radiation of a colorectal tumor in nude mouse. Anticancer Research 33, 3005-3014 (2013).
T. Tippayamontria, R. Kotb, B. Paquette & L. Sanche Radiation Damage to DNA: The Indirect Effect of Low-Energy Electrons
Journal of Physical Chemistry Letters 4, 820-825 (2013).
E. Alizadeh, A. G. Sanz, G. García & L. Sanche. Oxygen Attachment on Alkanethiolate SAMs Induced by Low-Energy Electron Irradiation. Langmuir 29, 5222-5229 (2013).
S. Massey, A. Bass, M. Steffenhagen & L. Sanche. Cisplatin enhances the formation of DNA single and double strand breaks by hydrated electrons and hydroxyl radicals.
Radiation Research 179, 323-331 (2013).
M. Rezaee, L. Sanche & D.J. Hunting. Synergism in Concomitant Chemoradiotherapy of Cisplatin and Oxaliplatin and their Liposomal Formulation in the Human Colorectal Cancer HCT116 Model.
Anticancer Research 32, 4395-404 (2012).
T. Tippayamontria, R. Kotb, B. Paquette & L. Sanche. Radiation-Induced Formation of 2′,3′-Dideoxyribonucleosides in DNA: A Potential Signature of Low-Energy Electrons.
Journal of the American Chemical Society 134, 17366-8 (2012).
G. Madugundu, Y. Park, L. Sanche & J.R. Wagner. Absolute cross section for low energy electron damage to condensed macromolecules: A case study of DNA. Physical Review E 86, 031913 (2012).
M. Rezaee, P. Cloutier, A.D. Bass, D.J. Hunting & L. Sanche. Absolute cross sections for vibrational excitations of cytosine by low energy electron impact. Journal of Chemical Physics 137, 115103 (2012).
M. Michaud, M. Bazin & L. Sanche. Fundamental Mechanisms of DNA Radiosensitization: Damage Induced by Low-Energy Electrons in Brominated Oligonucleotide Trimers.
Journal of Physical Chemistry B 116, 9676-82 (2012).
Y. Park, K. Polska, J. Rak, J.R. Wagner & L. Sanche. Precursors of solvated electrons in radiation biology.
Chemical Reviews 112, 5578-5602 (2012).
E. Alizadeh & L. Sanche. Low energy electron stimulated desorption from DNA films dosed with oxygen.
Journal of Chemical Physics, 136, 235104 (2012).
N. Mirsaleh Kohan, A.D. Bass, P. Cloutier, S. Massey & L. Sanche. Electron simulated desorption of anions from native and brominated single stranded oligonucleotide trimers. Journal of Chemical Physics 136, 075101 (2012).
K. Polska, J. Rak, A.D. Bass, P. Cloutier & L. Sanche. Glioblastoma treatment: Bypassing the toxicity of platinum compounds by using liposomal formulation and increasing treatment efficiency with concomitant radiotherapy.
International Journal of Radiation Oncology, Biology, Physics 84, 244-249 (2012).
G. Charest, B. Paquette, L. Sanche, D. Fortin & D. Mathieu. Induction of Strand Breaks in DNA films by Low Energy Electrons and Soft X-ray under Nitrous Oxide Atmosphere. Radiation Physics and Chemistry 81, 33-39 (2012).
E. Alizadeh & L. Sanche. DNA-Platinum Thin Films for Use in Chemoradiation Therapy Studies,
Bioinorganic Chemistry and Applications 2012, 923914-1-9 (2012).
M. Rezaee, E. Alizadeh, D. Hunting & L. Sanche. Measurement of inelastic cross sections for low-energy electron scattering from DNA bases. International Journal of Radiation Biology 88, 15-21 (2012).
M. Michaud, M. Bazin & L. Sanche. Measurements of G-values for DNA Damage Induced by Low Energy Electrons.
The Journal of Physical Chemistry B 115, 14852–14858 (2011).
E. Alizadeh & L. Sanche. Energy Dependence of Gold Nanoparticle Radio-Sensitisation in Plasmid DNA.
Journal of Physical Chemistry C 115, 20160–20167 (2011).
S. McMahon, W. Hyland, E. Brun, K. Butterworth, J. Coulter, T. Douki, D. Hirst, S. Jain, A. Kavanagh, Z. Krpetic, M. Mendenhall, M. Muir, K. Prise, H. Requardt, L. Sanche, G. Schettino, F. Currell & C. Sicard-Roselli. Soft adsorption of densely packed multi-layer of DNA-plasmid • 1, 3-diaminopropane complexes onto highly oriented pyrolitic graphite designed to erode in water.
Journal of Physical Chemistry C 115, 21291-21298 (2011).
O. Boulamouar, A. Khatyr, G. Herlem, F. Palmino, L. Sanche & M. Fromm. Low energy electron induced DNA damage in a trinucleotide containing 5-bromouracil.
Journal of Physical Chemistry B 115, 13668–13673 (2011).
Z. Li, P. Cloutier, L. Sanche & J.R. Wagner. Soft X-ray and LEE induced damage to DNA in N2 and O2 atmospheres.
The Journal of Physical Chemistry B 115, 4523-4531 (2011).
E. Alizadeh, P. Cloutier, D. Hunting & L. Sanche. DNA damage induced by low energy electrons: Conversion of thymine to
5, 6-dihydrothymine in the oligonucleotide trimer TpTpT.
Radiation Research 175, 240-246 (2011).
Y. Park, Z. Li, P. Cloutier, L. Sanche & J.R. Wagner. Effect of morphology of thin DNA films on the electron stimulated desorption of anions. The Journal of Chemical Physics 134, 015102 (2011).
N. Mirsaleh-Kohan, A.D. Bass & L. Sanche. Cellular uptake and cytoplasm/DNA distribution of liposomal formulation of cisplatin and oxaliplatin in human colorectal cancer cell HCT116.
Invest New Drugs 29, 1321–1327 (2011).
T. Tippayamontri, R. Kobt, B. Paquette & L. Sanche. Absolute cross sections for electronic excitations of cytosine by low energy electron impact. Journal of Chemical Physics 133, 155104 (2010).
M. Bazin, M. Michaud & L. Sanche. “Damage to amino acid-nucleotide pairs induced by 1 eV electrons.
Physical Chemistry Chemical Physics 12, 9367-9372 (2010).
S. Ptasińska, Z. Li, N.J. Mason & L. Sanche. Electron Stimulated Desorption of anions and cations from condensed allyl-glycidyl ether”. Physical Chemistry Chemical Physics 12, 7950-8 (2010).
Y. Yildirim, M. Balcan A.D. Bass, P. Cloutier & L. Sanche. Preferential tumor accumulation of gold nanoparticles, visualized by magnetic resonance imaging: radiosensitization studies in vivo and in vitro.
International Journal of Radiation Biology 86, 692-700 (2010).
E. Hébert, P.-J. Debouttière, M. Lepage, L. Sanche & D.J. Hunting. Low Energy Electron Induced DNA Damage: Effect of Base Sequence in Oligonucleotide Trimers.
Journal of the American Chemical Society 132, 5422–5427 (2010).
Z. Li, P. Cloutier, L. Sanche & J.R. Wagner. XPS analysis of gold surfaces after removal of thiolated DNA oligomers by UV/ozone treatment. Langmuir 26, 6508–6514 (2010).
N. Mirsaleh-Kohan, A.D. Bass & L. Sanche. Electron induced dissociation in the condensed-phase nitromethane: II Desorption of neutral fragments. Journal of Physics Condensed Matter 22, 084003 (2010).
M. Bazin, S. Ptasińska, A.D. Bass, L. Sanche, E. Burean & P. Swiderek. Electron Stimulated Desorption of Anions Containing Oxygen and Nitrogen from Self-Assembled Monolayers of DNA.
Journal of Physics: Conference Series 204, 012005 (2010).
N. Mirsaleh-Kohan, A.D. Bass, P. Cloutier & L. Sanche. Concomittant treatment of F98 glioma cells with new liposomal compounds and ionizing radiation. Journal of Neuro-Oncology 97, 187–193 (2010).
G. Charest, B. Paquette, D. Fortin, D. Mathieu & L. Sanche. Low-energy electrons and X-ray irradiation effects on plasma-polymerized allylamine bioactive coatings for stents. Polymer Degradation and Stability 95, 153-163 (2010).
S. Massey, E. Gallino, P. Cloutier, M. Tatoulian, L. Sanche, D. Mantovani & D. Roy. Protection by organic ions against DNA damage induced by low energy electrons .
Journal of Chemical Physics 132, 045102 (2010).
A. Dumont, Y. Zheng, D. Hunting & L. Sanche. Biological chemistry: Beyond radical thinking.
Nature 461, 358-359 (2009).
L. Sanche. Low-energy electron scattering from DNA including structural water and base-pair irregularities. Physical Review A 80, 012705-1-6 (2009).
L. Caron, L. Sanche, S. Tonzani & C.H. Greene. Damage Induced to DNA by Low-Energy (0-30 eV) Electrons under Vacuum and Atmospheric Conditions. Journal of Physical Chemistry B 113, 10008–10013 (2009).
E. Brun, P. Cloutier, C. Sicard-Roselli, M. Fromm & L. Sanche. Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution”.
Colloids Surface B Biointerfaces 72, 128–134 (2009).
E. Brun, L. Sanche & C. Sicard-Roselli. Polymer gel in rat skull to assess the accuracy of a new rat stereotactic device for use with the Gamma Knife. Acta Neurochirurgica 151, 677–684 (2009).
G. Charest, D. Mathieu, M. Lepage, D. Fortin, B. Paquette & L. Sanche. Gold nanoparticles enhanceDNA damage induced by anti-cancer drugs and radiation.
Radiation Research, 172, 114-119 (2009).
Y. Zheng & L. Sanche. “Role of secondary low energy electrons in radiobiology and chemoradiation therapy of cancer”. Chemical Physics Letters 474, 1-6 (2009).
L. Sanche. Electron induced dissociation in the condensed-phase nitromethane: I. Desorption of ionic fragments. Physical Chemistry Chemical Physics 11, 1610-8 (2009).
M. Bazin, S. Ptasińska, A.D. Bass & L. Sanche. Gold nanoparticles enhance the X-ray-induced degradation of human centrin 2 protein.
Radiation Physics and Chemistry 78, 177–183 (2009)
E. Brun, P. Duchambon, Y. Blouquit, G. Keller, L. Sanche & C. Sicard-Roselli. Radiosensitization by gold nanoparticles: Comparison of DNA damage induced by low and high-energy electrons. Journal of Biomedical Nanotechnology 4, 469-481 (2008).
Y. Zheng, P. Cloutier, D.J. Hunting & L. Sanche. Chemical synthesis induced by dissociative electron attachment.
Journal of Physical Chemistry C 112, 17319-17326 (2008).
M. Rajappan, L. Zhu, A. Bass, L. Sanche & C. Arumainayagam. Diffraction in low-energy electron scattering from DNA: bridging gas phase and solid state theory. Physical Review A 78, 042710 (2008).
L.G. Caron, S. Tonzani, C.H. Greene & L. Sanche. Revisiting the electron stimulated desorption of anions from thin films of CF2CL2.
International Journal of Mass Spectrometry 277, 251-255 (2008).
A.D. Bass, C.R. Arumainayagam & L. Sanche. Small steps on the slippery road to life: Molecular synthesis in astrophysical ices initiated by low energy electron impact.
International Journal of Mass Spectrometry 277, 256–261 (2008).
M.A. Huels, L. Parenteau, A.D. Bass & L. Sanche. DNA damage by X-ray and low energy electron beam irradiation.
Journal of Radiation Protection, 23, 53-59 (2008).
Y.S. Park, Y.A. Noh, H. Cho, A. Dumont, S. Ptasińska, A.D. Bass & L. Sanche. X-ray induced damage in DNA monitored by X-ray photoelectron spectroscopy.
Journal of Chemical Physics, 129, 065102 (2008).
S. Ptasińska, A. Stypczyńska, T.Nixon, N.J. Mason, D.V. Klyachko & L. Sanche. Electron transfer reactions for image and image-derived states in dielectric thin films.
Journal of Chemical Physics, 129, 074703-1-9 (2008).
E.T. Jensen & L. Sanche. Low energy electron attachment to condensed formic acid
Journal of Physics Conference Series 115,012018-1-8 (2008).
S. Ptasińska, A.D. Bass & L. Sanche. Mass spectrometry investigation of the degradation of polyethylene terephtalate induced by low-energy (<100 eV) electrons.
Radiation Physics and Chemistry 77, 889–897 (2008).
S. Massey, P. Cloutier, L. Sanche & D. Roy. Role of secondary low-energy electrons in the concomitant chemoradiation therapy of cancer. Physical Review Letters 100, 198101 (2008).
Y. Zheng, D.J. Hunting, P. Ayotte, and L. Sanche. Low Energy Electron Induced DNA Damage: Effects of Terminal Phosphate and Base Moieties on the Distribution of Damage.
Journal of the American Chemical Society 130, 5612–5613 (2008).
Z. Li, Y. Zheng, P. Cloutier, L. Sanche & J.R. Wagner. Chemical modication of polystyrene by low-energy (<100 eV) electron irradiation studied by mass spectrometry.
Journal of Applied Polymer Science 108, 3163–3168 (2008).
S. Massey, P. Cloutier, M. Bazin, L. Sanche & D. Roy. Multiple scattering approach to elastic low-energy electron collisions with the water dimer. Journal of Physics B: Atomic, Molecular and Optical Physics 41, 045204 (2008).
D. Bouchiha, L.G. Caron, J.D. Gorfinkiel & L. Sanche. Low-energy electron and X-ray degradation of biomedical plasma-fluoropolymer
Polymer Degradation and Stability 93, 383-391 (2008).
S. Massey, P. Cloutier, P. Hale, M. Bazin, L. Sanche D. Mantovani & D. Roy. TDAB-induced DNA plasmid condensation on the surface of a reconstructed boron doped silicon substrate Surface Science 602, 142-150 (2008).
A. Mougin, V.G. Babak, F. Palmino, E. Bêche, F. Baros, D.J. Hunting, L. Sanche &
M. Fromm. Radiosensitization of DNA by gold nanoparticles irradiated with high energy electrons
Radiation Research 169, 19-27 (2008).
Y. Zheng, D.J. Hunting, P. Ayotte & L. Sanche. “From DNA to nucleic bases - the effects of low-energy electron impact”
Journal of Physics: Conference Series 88, 012074-1-8 (2007).
R. Panajotovic, M. Michaud & L. Sanche. Low-energy electron induced processes in fluorinated copper phthalocyanine films observed by F-desorption: Why so little damage.
Journal of Physical Chemistry 111, 12427-12433 (2007).
D. Menzel, P. Cloutier, L. Sanche & T.E. Madey. Adapting gas phase electron scattering R-matrix calculations to a condensed matter environment Physical Review A 76, 032716-1-7 (2007).
L. Caron, D. Bouchiha, J.D. Gorfinkiel & L. Sanche. Elastic scattering of electrons and positrons.
Journal of the International Commission on Radiation Unit, ICRU Report 77, ISSN 1473-6691, 7, 1-151 (2007).
L. Sanche et al. Low-energy electron transmission through thin-film molecular and biomolecular solids.
Chemical Reviews 107, 1553-1579 (2007).
R. Naaman & L. Sanche. Low energy electron stimulated desorption of ions from whole human blood.
International Journal of Mass Spectrometry 263, 179–184 (2007).
S. Ptasińska & L. Sanche. Dissociative electron attachment to abasic DNA.
Physical Chemistry Chemical Physics 9, 1730-1735 (2007).
S. Ptasińska & L. Sanche. Dissociative electron attachment to hydrated single DNA strands.
Physical Review E 75, 031915-1-5 (2007)
S. Ptasińska & L. Sanche. Low-energy electron collisions with methanol.
Journal of Physics B: Atomic, Molecular and Optical Physics 40 1259–1270 (2007).
D. Bouchiha, J.D. Gorfinkiel, L.G. Caron & L. Sanche. Low-energy (3-24 eV) electron damage to the peptide backbone.
The Journal of Physical Chemistry B 111, 1620-1624 (2007).
P. Cloutier, C. Sicard-Roselli, E. Escher & L. Sanche. Cross sections for low-energy electron scattering from adenine in the condensed phase.
Physical Chemistry Chemical Physics 9, 138-48 (2007).
R. Panajotović, M. Michaud & L. Sanche. Electron photoemission from charged films: Absolute cross section for trapping 0-5 eV electrons in condensed CO2. The Journal of Chemical Physics 126, 024701 (2007).
M. Michaud, E.M. Hébert, P. Cloutier & L. Sanche. On the mechanism of anion desorption from DNA induced by low energy electrons.
The Journal of Chemical Physics 125, 144713 (2006).
S. Ptasinska & L. Sanche. Absolute cross section for trapping low-energy electrons (0-18 eV) in molecular films of n-hexane. Journal of Applied Physics 100, 073705-1-9 (2006).
M. Michaud, E. Hébert, P. Cloutier & L. Sanche. Electron stimulated desorption of anionic fragments from films of pure and electron-irradiated thiophene. Journal of Chemical Physics 125, 094704-1-12 (2006).
M.N. Hedhilli, P. Cloutier, A.D. Bass, T.E. Madey & L. Sanche. Cross sections for electron trapping by DNA and its component subunits I: Condensed tetrahydrofuran deposited on Kr. The Journal of Chemical Physics 125, 074714 (2006).
Y.S. Park, H. Cho, L. Parenteau, A.D. Bass & L. Sanche. Products and reaction sequences in tetrahydrofuran exposed to low-energy electrons.
Journal of Physical Chemistry B, 110, 12512-22 (2006).
C. Jäggle, P. Swiderek, S.-Ph. Breton, M. Michaud & L. Sanche. Temporary electron localization and scattering in disordered single-strands of DNA.
Physical Review A, 73, 062707-1-062707-7 (2006).
L.G. Caron & L. Sanche. Base Release in Nucleosides Induced by Low-Energy Electrons: A DFT Study
Radiation Research, 165, 721-729 (2006).
X. Li, L. Sanche & M.D. Sevilla. DNA damage induced by low energy electrons: electron transfer and diffraction.
Physical Review Letters 96, 208101-1-208101-4 (2006).
Y. Zheng, R. Wagner & L. Sanche. Dissociative electron attachment to DNA basic constituents: the phosphate group.
Chemical Physics Letters, 421, 404-408 (2006).
X. Pan & L. Sanche. Effective cross sections for single strand break production in plasmid DNA by 0.1 to 4.7 eV electrons. Radiation Research 165, 452-459 (2006).
R. Panajotovic, F. Martin, P. Cloutier, D.J. Hunting & L. Sanche Phosphodiester and N-glycosidic bond cleavage in DNA induced by 4-15 eV electrons.
Journal of Chemical Physics, 124, 064710-1-9 (2006).
Y. Zheng, P. Cloutier, D.J. Hunting, J.R. Wagner & L. Sanche. Enhanced DNA damage induced by secondary electron emission from a tantalum surface exposed to soft X-rays. Radiation Research, 165, 365-371(2006).
Z.Cai, P. Cloutier, D. Hunting & L. Sanche. Induction of strand breaks by low energy electrons (8-68 eV) in a self-assembled monolayer of oligonucleotides: Effective cross-sections and attenuation lengths.
Journal of Chemical Physics, 124, 024705-1-5 (2006).
Z. Cai, M.-E. Dextraze, P. Cloutier, D. Hunting & L. Sanche. Low energy electron collisions with tetrahydrofuran.
J. Phys. B: At. Mol. Op. Phys., 39, 975-986 (2006).
D. Bouchiha, J.D. Gorfinkiel, L.G. Caron &L. Sanche. Interstrand cross-link induction by UV radiation in bromodeoxyuridine substituted DNA: dependence on DNA conformation. Biochemistry, 44, 16957-16966 (2005).
S. Cecchini, C. Masson, C. La Madeleine, M.A. Huels, L. Sanche & D.J. Hunting. Chemical basis of DNA sugar-phosphate cleavage by low-energy electrons.
Journal of the American Chemical Society, 127, 16592-16598 (2005).
Y. Zheng, P. Cloutier, D.J. Hunting, L. Sanche & J.R. Wagner. Double sublimation system to deposit molecules from solid organic compounds onto a cryogenic substrate: Thymine on solid argon.
Review of Scientific Instruments, 76, 103901-103906 (2005).
P. Lévesque, M. Michaud & L. Sanche. Diffraction in resonant electron scattering from helical macromolecules: Effects of the DNA backbone. Physical Review A, 72, 032726-1-6 (2005).
L. Caron & L. Sanche. Low energy electron-driven damage in biomolecules.
European Physics Journal D – Atom., Mol. Opt. Phys., 35, 367-390 (2005).
L. Sanche. Response to Dr. Ward's comments on sensitization of single stranded DNA.
Radiation Reseach, 164, 342 (2005).
S. Cecchini, S. Girouard, M.A. Huels, L. Sanche & D.J. Hunting. Low energy electron and O¯ reactions in films of O2 coadsorbed with benzene or toluene. Physical Chemistry Chemical Physics, 7, 3359-5567 (2005).
M. Imhoff, L. Parenteau, L. Sanche & M.A. Huels. Absolute electronic excitation cross sections for low-energy electron (5-12 eV) scattering from condensed thymine.
Journal of Chemical Physics, 122, 224704-1-7 (2005).
P.L. Lévesque, M. Michaud, W. Cho & L. Sanche. Mechanism and site of attack for direct damage to DNA by low-energy electrons.
Physical Review Letters, 94, 198104-1-4 (2005).
X. Pan & L. Sanche. Electron attachment in ice-HCl clusters: An Ab Initio study.
Journal of Physical Chemistry, 109, 4591-4600 (2005).
X. Li, L. Sanche, A. Rauk & D. Armstrong. Interstrand cross-links: a new type of gamma ray damage in bromodeoxyuridine substituted DNA. Biochemistry, 44, 1932-1940 (2005).
S. Cecchini, S. Girouard, M.A. Huels, L. Sanche & D.J. Hunting. Comparison between X-ray photon and secondary electron damage to DNA in vacuum.
Journal of Physical Chemistry B, 109, 4796-4800 (2005).
Z. Cai, P. Cloutier, D. Hunting & L. Sanche. Absolute vibrational and electronic cross sections for low-energy electron (2-12 eV) scattering from condensed pyrimidines.
Journal of Chemical Physics, 122, 094701-1-095701-10 (2005).
P.L. Lévesque, M. Michaud & L. Sanche. Cross sections for electron scattering from selected components of DNA and RNA.
Radiation Physics and Chemistry, 73, 74-84 (2005).
P. Mozejko & L. Sanche. DNA inter-duplex crosslinks induced by AlKa X-rays under vacuum.
Radiation Research, 164, 173-179 (2005).
Z. Cai, P. Cloutier, L. Sanche & D. Hunting. D¯, O¯ and OD¯ desorption induced by low-energy (0-20 eV) electron impact on amorphous D2O films. Radiation Physics and Chemistry, 72, 193-199 (2005).
X. Pan, H. Abdoul-Carime, P. Cloutier, A.D. Bass & L. Sanche. Publications représentatives Resonant formation of DNA strand breaks by low energy (3-20 eV) electrons. Science 287, 1658-1660 (2000). B. Boudaiffa, P. Cloutier, D. Hunting, M.A. Huels & L. Sanche. Cross sections for low-energy (1-100 eV) electron elastic and inelastic scattering in amorphous ice. Radiation Research, 159, 3-22 (2003). M. Michaud, A. Wen & L. Sanche. Dissociative electron attachment to DNA. Physical Review Letters, 90, 208102-1-208102-4 (2003). X. Pan, P. Cloutier, D. Hunting & L. Sanche. Density functional theory studies of electron interaction with DNA: Can zero eV electrons induce strand breaks? Journal of the American Chemical Society, 125, 13668-13669 (2003). X.F. Li, M.D. Sevilla & L. Sanche. DNA strand breaks induced by 0-4 eV electrons: the role of shape resonances. Physical Review Letters, 93, 068101-1-4 (2004). F. Martin, P.D. Burrow, Z. Cai, P. Cloutier, D.J. Hunting & L. Sanche. Low energy electron attachment to condensed formic acid Journal of Physics Conference Series 115, 012018-1-8 (2008).S. Ptasińska, A.D. Bass & L. Sanche. Gold nanoparticles enhance DNA damage induced by anti-cancer drugs and radiation. Radiation Research, 172, 114-119 (2009). Y. Zheng & L. Sanche. Biological chemistry: Beyond radical thinking.Nature 461, 358-359 (2009). L. Sanche. Low Energy Electron Induced DNA Damage: Effect of Base Sequence in Oligonucleotide Trimers. Journal of the American Chemical Society 132, 5422–5427 (2010). Z. Li, P. Cloutier, L. Sanche & J.R. Wagner. On the role of low-energy electrons in the radiosensitization of DNA by gold nanoparticles. Nanotechnology 22, 465101 (2011). F. Xiao, Y. Zheng, P. Cloutier, Y. He, D. Hunting & L. Sanche. Precursors of solvated electrons in radiation biology. Chemical Reviews 112, 5578-5602 (2012). E. Alizadeh & L. Sanche. Efficacy of Cisplatin and Lipoplatin™ in combined treatment with radiation of a colorectal tumor in nude mouse. Anticancer Research 33, 3005-3014 (2013). T. Tippayamontria, R. Kotb, B. Paquette & L. Sanche New Insights into the Mechanism Underlying the Synergistic Action of Ionizing Radiation with Platinum Chemotherapeutic Drugs: The Role of Low-Energy Electrons. International Journal of Radiation Oncology Biology Physics 87, 847-53 (2013). M. Rezaee, D.J. Hunting & L. Sanche. “Electron Resonance Decay into a Biological Function: Decrease in Viability of E. coli Transformed by Plasmid DNA Irradiated with 0.5−18 eV Electrons.” Journal of Physical Chemistry Letters, 6, 3911−3914 (2015) S. Kouass Sahbani, P. Cloutier, A. D. Bass, D. J. Hunting, & L. Sanche “Cancer treatment: Low-energy electron therapy.” Nature Materials, 14, 861–863 (2015) L. Sanche “Interaction of low energy electrons with DNA: Applications to cancer radiation therapy” Radiation Physics and Chemistry 128, 36-43 (2016). L. Sanche. Ressources
- 10 systèmes « hyper-vide » permettant d'utiliser plusieurs techniques d'analyse d'échantillons
- Les techniques accessibles sont :
- La désorption d'ions et de radicaux stimulée par impact d'électrons
- La spectroscopie par transmission d'électrons de faible énergie (LEET)
- La spectroscopie à haute résolution par perte d'énergie d'électrons (HREEL)
- Piégeage de charges par la technique LEET et par la sonde Kelvin
- La spectroscopie de photoélectrons XPS
- Irradiateurs par électrons de faible énergie
- Analyse des produits induits par la radiation ionisante et les électrons de basse énergie, par la spectrométrie de masse, le gel électrophorèse et la chromatographie liquide à haute pression
- Méthode de manipulation des échantillons de molécules lourdes d'intérêt biologique
- Refroidissement des échantillons à analyser jusqu' à 15K par des cryostats (à cycle fermé)
- Les dispositifs électroniques et les programmes informatiques pour l'acquisition des données, «faits maison » ou commerciaux