Épisode 40 : Efficacité et sécurité de la sémaglutide chez les sujets avec embonpoint ou obésité (étude STEP1)

Diffusé le 24 mars 2021

Dans cette 40e baladodiffusion, les Drs Luc Lanthier et Marie-France Langlois discutent de sémaglutide dans le traitement de l’obésité, en plus de réviser la littérature médicale de janvier et février 2021.

Quiz clinique (5 min 05), article principal (6 min 04), critique (26 min 23), autres articles (43 min 10), réponse au quiz clinique (48 min 07)

Référence principale

Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. PubMed PMID: 33567185.

Infographie

Article résumé

Lanthier L, Langlois MF, Plourde MÉ, Cauchon M. Chez les sujets avec obésité ou embonpoint associé à une comorbidité, quelle est l’efficacité et la sécurité de la sémaglutide combinée à une intervention sur le mode de vie pour réduire le poids corporel et d’autres paramètres associés comparativement au placébo ?  Rev Med Interne. 2021;42:369-70. PubMed PMID : 33838950.

Articles associés

Wharton S, Lau DCW, Vallis M, Sharma AM, Biertho L, Campbell-Scherer D, et al. Obesity in adults: a clinical practice guideline. CMAJ. 2020;192(31):E875-E91. PubMed PMID : 32753461.

Ingelfinger JR, Rosen CJ. STEP 1 for Effective Weight Control - Another First Step? N Engl J Med. 2021;384(11):1066-1067. PubMed PMID: 33567184.

Latini R, Staszewsky L. Semaglutide and effective weight control. Lancet. 2021;397(10278):942-943. PubMed PMID: 33667415.

Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, et al; SCALE Obesity and Prediabetes NN8022-1839 Study Group. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015;373(1):11-22. PubMed PMID: 26132939.

Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, et al; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021;397(10278):971-984. PubMed PMID: 33667417.

Wadden TA, Bailey TS, Billings LK, Davies M, Frias JP, Koroleva A, et al; STEP 3 Investigators. Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial. JAMA. 2021 Feb 24:e211831. PubMed PMID: 33625476.

Kushner RF, Calanna S, Davies M, Dicker D, Garvey WT, Goldman B, et al. Semaglutide 2.4 mg for the Treatment of Obesity: Key Elements of the STEP Trials 1 to 5. Obesity (Silver Spring). 2020;28(6):1050-1061. PubMed PMID: 32441473.

https://obesitycanada.ca/

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Capsule méthodologique

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. PMID: 31462531.

Références du quiz clinique

Albassam OT, Redelmeier RJ, Shadowitz S, Husain AM, Simel D, Etchells EE. Did This Patient Have Cardiac Syncope?: The Rational Clinical Examination Systematic Review. JAMA. 2019;321(24):2448-2457. PMID: 31237649.

Sheldon R, Rose S, Ritchie D, Connolly SJ, Koshman ML, Lee MA, Frenneaux M, Fisher M, Murphy W. Historical criteria that distinguish syncope from seizures. J Am Coll Cardiol. 2002;40(1):142-8. PMID: 12103268.

Shmuely S, Bauer PR, van Zwet EW, van Dijk JG, Thijs RD. Differentiating motor phenomena in tilt-induced syncope and convulsive seizures. Neurology. 2018 Apr 10;90(15):e1339-e1346. PMID: 29549227.