Épisode 36 : Colchicine chez les sujets avec maladie coronarienne stable (étude LoDoCo2)

Diffusé le 18 septembre 2020

Dans cette 36e baladodiffusion, les Drs Luc Lanthier et Charles Dussault discutent de l’efficacité de la colchicine chez les sujets avec maladie coronarienne athérosclérotique chronique et stable, en plus de réviser la littérature médicale d’août 2020.

Quiz clinique (2 min 10), article principal (2 min 40), critique (18 min 07), autres articles (24 min 47), réponse au quiz clinique (28 min 05)

Référence principale

Nidorf SM, Fiolet ATL, Mosterd A, Eikelboom JW, Schut A, Opstal TSJ, et al. Colchicine in Patients with Chronic Coronary Disease. N Engl J Med. 2020;383(19):1838-47. PubMed PMID : 32865380.

Infographie

Article résumé

Lanthier L, Dussault C, Huard G, Plourde MÉ, Cauchon M. Chez les patients avec maladie coronarienne athérosclérotique chronique stable, quelle est l’efficacité de la colchicine pour prévenir les événements cardiovasculaires et son innocuité comparativement au placébo?  Rev Med Interne. 2020 (accepté pour publication). PubMed PMID: 33168351

Articles associés

WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne JAC, Murthy S, et al. Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis. JAMA. 2020;324(10):1330-41. PubMed PMID  : 32876694.

Gaudino M, Arvind V, Hameed I, Di Franco A, Spadaccio C, Bhatt DL, et al. Effects of the COVID pandemic on active non-COVID clinical trials. [published online ahead of print, 2020 Jul 29]. J Am Coll Cardiol. 2020;S0735-1097(20)36164-7. PubMed PMID : 32745501.

Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL. Low-dose colchicine for secondary prevention of cardiovascular disease. J Am Coll Cardiol. 2013;61(4):404-410. PubMed PMID: 23265346.

Ridker PM, Everett BM, Pradhan A, MacFadyen JG, Solomon DH, Zaharris E, et al. Low-Dose Methotrexate for the Prevention of Atherosclerotic Events. N Engl J Med. 2019;380(8):752-62. PubMed PMID: 30415610.

Tardif J-C, Kouz S, Waters DD, Bertrand OF, Diaz R, Maggioni AP, et al. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med. 2019;381(26):2497-2505. PubMed PMID : 31733140.

Tong DC, Quinn S, Nasis A, et al. Colchicine in Patients with Acute Coronary Syndrome: The Australian COPS Randomized Clinical Trial. Circulation. 2020;142(20):1890-1900. PubMed PMID : 32862667.

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Guides de pratique récents

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Référence du quiz clinique

Hydes TJ, Burton R, Inskip H, Bellis MA, Sheron N. A comparison of gender-linked population cancer risks between alcohol and tobacco: how many cigarettes are there in a bottle of wine?. BMC Public Health. 2019;19(1):316. PubMed PMID : 30917803.

GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2018;392(10152):1015-1035. PubMed PMID : 30146330.

Manthey J, Shield KD, Rylett M, Hasan OSM, Probst C, Rehm J. Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study. Lancet. 2019;393(10190):2493-2502. PubMed PMID : 31076174.