Épisode 35 : Dexaméthasone chez les sujets hospitalisés pour la COVID-19 (étude RECOVERY)

Diffusé le 28 août 2020

Dans cette 35e baladodiffusion, les Drs Luc Lanthier et Michaël Mayette discutent de l’efficacité de la dexaméthasone dans le traitement des patients hospitalisés pour la COVID-19, en plus de réviser la littérature médicale de juin et juillet 2020.

Quiz clinique (2 min 10), article principal (2 min 40), critique (18 min 07), autres articles (24 min 47), réponse au quiz clinique (28 min 05)

Référence principale

Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, et al. Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report. N Engl J Med. 2020. PubMed PMID: 32678530.

Infographie

Articles associés

Lane HC, Fauci AS. Research in the Context of a. N Engl J Med. 2020;NEJMe2024638. PubMed PMID : 32678528.

Normand ST. The RECOVERY Platform. N Engl J Med. 2020;NEJMe2025674. PubMed PMID : 32706531.

Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. Remdesivir for the Treatment of Covid-19 - Preliminary Report. N Engl J Med. 2020. PubMed PMID : 32445440

Tang W, Cao Z, Han M, Wang Z, Chen J, Sun W, et al. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial. BMJ. 2020;369:m1849. PubMed PMID : 32409561

Boulware DR, Pullen MF, Bangdiwala AS, et al. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. N Engl J Med. 2020;383(6):517-525. PubMed PMID : 32492293.

Fosbol EL, Butt JH, Ostergaard L, Andersson C, Selmer C, Kragholm K, et al. Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality. JAMA. 2020. PubMed PMID : 32558877.

Shafran DM, Bunce PE, Gold WL. Reducing the risk of infection in a 74-year-old man who is to receive prednisone. CMAJ. 2014;186(16):1239-1240. PubMed PMID : 25024293.

Pericàs JM, Hernandez-Meneses M, Sheahan TP, et al. COVID-19: from epidemiology to treatment. Eur Heart J. 2020;41(22):2092-2112. PubMed PMID: 32511724.

https://www.inesss.qc.ca/covid-19/traitements-specifiques-a-la-covid-19/dexamethasone-mise-a-jour-completee-03-08-2020.html

https://www.inesss.qc.ca/covid-19/etudes-cliniques-en-cours-prophylaxie-et-traitement.html

https://covid-nma.com

https://www.bmj.com/content/370/bmj.m2980

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