Publications Pr Marsault

1- Murza A, Parent A, Besserer-Offroy E, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault E, .

Titre: Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.

ChemMedChem. 2012 Feb 6;7(2):318-25.

2- Mitchell G, Lafrance M, Boulanger S, Seguin DL, Guay I, Gattuso M, Marsault E, Bouarab K, Malouin F.

Titre: Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression.

J Antimicrob Chemother. 2012 Mar;67(3):559-68. Epub 2011 Nov 30.

3- Hoveyda HR, Marsault E, Gagnon R, Mathieu AP, Vezina M, Landry A, Wang Z, Benakli K, Beaubien S, Saint-Louis C, Brassard M, Pinault JF, Ouellet L, Bhat S, Ramaseshan M, Peng X, Foucher L, Beauchemin S, Bherer P, Veber DF, Peterson ML, Fraser GL.

Titre: Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic.

J Med Chem. 2011 Dec 22;54(24):8305-20. Epub 2011 Nov 22.

4- Marsault E, Peterson ML.

Titre: Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.

J Med Chem. 2011 Apr 14;54(7):1961-2004. Epub 2011 Mar 7.

5- Mitchell G, Gattuso M, Grondin G, Marsault E, Bouarab K, Malouin F.

Titre: Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells.

Antimicrob Agents Chemother. 2011 May;55(5):1937-45. Epub 2011 Feb 28.

6- Marsault E, Hoveyda HR, Peterson ML, Gagnon R, Vezina M, Pinault JF, Landry A, Saint-Louis C, Ouellet LG, Beauchemin S, Benakli K, Beaubien S, Brassard M, Wang Z, Champagne M, Galaud F, Fortin N, Fortin D, Plourde V, Ramaseshan M, Bhat S, Bilodeau F, Lonergan D, Lan R, Li S, Berthiaume G, Foucher L, Peng X, Dory Y, Deslongchamps P.

Titre: High throughput solid phase parallel synthesis of macrocyclic peptidomimetics.

Adv Exp Med Biol. 2009;611:15-6.

7- Beaubien S, Hoveyda HR, Vezina M, Marsault E, Tremblay H, Foucher L, Benakli K.

Titre: Parallel solid-phase synthesis of macrocyclic peptidomimetics using Ru-catalyzed ring-closing metathesis and a new application of cross metathesis.

Adv Exp Med Biol. 2009;611:13-4.

8- Marsault E, Hoveyda HR, Gagnon R, Peterson ML, Vezina M, Saint-Louis C, Landry A, Pinault JF, Ouellet L, Beauchemin S, Beaubien S, Mathieu A, Benakli K, Wang Z, Brassard M, Lonergan D, Bilodeau F, Ramaseshan M, Fortin N, Lan R, Li S, Galaud F, Plourde V, Champagne M, Doucet A, Bherer P, Gauthier M, Olsen G, Villeneuve G, Bhat S, Foucher L, Fortin D, Peng X, Bernard S, Drouin A, Deziel R, Berthiaume G, Dory Y, Fraser GL, Deslongchamps P.

Titre: Efficient parallel synthesis of macrocyclic peptidomimetics.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4731-5. Epub 2008 Jun 28.

9- Marsault E, Benakli K, Beaubien S, Saint-Louis C, Deziel R, Fraser G.

Titre: Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids.

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4187-90. Epub 2007 May 18.

10- Marsault E, Hoveyda HR, Peterson ML, Saint-Louis C, Landry A, Vezina M, Ouellet L, Wang Z, Ramaseshan M, Beaubien S, Benakli K, Beauchemin S, Deziel R, Peeters T, Fraser GL.

Titre: Discovery of a new class of macrocyclic antagonists to the human motilin receptor.

J Med Chem. 2006 Nov 30;49(24):7190-7.