Professors for the programs of physiology
- Physiology of the fat tissue
- Pharmacokinetics of the insulin
- Gestationnel diabetes
- Type 2 diabetes
- Complications of the pregnancy: prééclampsie, foetal delay of growth, gestationnel diabetes, prematurity and abortion.
- Infertility and endometriosis
- Gynecological cancers
- Lysosomal storage disorders.
Department of medicine (service of endocrinology)
- Role of the action of the insulin in the syndrome of polykystiques ovaries.
- Insulin resistance and alternative pathways in insulin signalisation via D-chiro-inositol.
- Pathogenesis of the type 2 diabetes.
- Metabolism of lipids and lipoproteins.
- Interactions between the metabolism of the food fatty acids and the dysfonction of the immune system
- Mechanisms of the cardiac lipotoxicity in the type 2 diabetes.
- Cerebral mechanisms underlying the normal vision and pathophysiology.
Department of Physiology and Biophysics
Head of the Master and PhD programs in physiology.
- Study of the molecular mechanisms of the regulation of the epithelial amiloride sensitive sodium channel (ENaC).
- Metabolism and cognition during the ageing.
- Cardiac electrophysiology. Molecular biology of the sodium channels.
- Study of the electrophysiological characteristics and adrenergic modulation of ion channel mutations involved in inherited cardiac diseases such as Long QT (LQT) and Brugada syndromes.
- Expression and distribution of sodium and potassium (KCNQ1, KCNE1) ion channel genes in the heart ventricles, atrium and conduction pathway and their potential contribution to arrhythmias.
- Studying the neural control of locomotion by the central nervous system before and after injury to the spinal cord and/or peripheral nerves.
- Evaluating adaptive neuromuscular mechanisms that facilitate locomotor recovery following spinal cord injury.
- Devising or improving approaches to facilitate the recovery of locomotion following spinal cord injury, such as pharmacotherapy and strength training.
- Functional regulation of the ACTH receptor (adrenocorticotrophine hormone)
- Role of the cellular environment and the cytosquelette in the mechanisms of action of hormones angiotensin II and ACTH in the cerebral cortex of the adrenal gland
- Mechanisms of action of certain proteins playing a major role in the development and the functions of the cerebral cortex of the adrenal gland(DAX-1; Seladin-1).
- Role and mechanism of action of the receptor AT2 of the angiotensin II in the neuronal differentiation
- Involvement of glucocorticoids, melanocortins and angiotensin II in the development of the obesity and of the resistance in the insulin.
Department of Physiology and Biophysics
Responsible and Director of the thematic inflammation and pain.
- Study of the roles and regulation of the opioid receptor delta.
- Study of chronic pain (inflammatory and neuropathic) and of the anxiety / depression.
- Evaluation of the analgesic properties and the side effects of drugs.
- Study of the pathways associated with the activation of the receptors coupled with G proteins .
- Mechanisms of induction of apoptosis of epithelial cells of kidney glomeruli and glomerular dysfunction causing diabetic nephropathy.Understanding of metabolic disorders of glucose and lipids on the regulation of signaling pathways of VEGF, angiopoietins and angiotensin leading to kidney failure.
- Understanding the mechanisms leading to resistance to insulin and other growth factors related to the inhibition of angiogenic pathways in the formation of new blood vessels following ischemia. Study of the role of protein kinase C and other glucose metabolites on endothelial dysfunction.
- Characterization of the role of the metabolism of glucose and fatty acids in the formation of atherosclerotic plate.
- Outline the critical, common steps involved in the development of neurological diseases.
- Help identify treatments that could delay or prevent brain degeneration.
- Explore the biology of caspase-6 and other caspases to develop successful treatments to slow or prevent nerve cell atrophy.
- Interaction of the oxydatif status on the regulation and the mechanisms of transduction of the type D2 dopaminergic receptors.
- Role of adipokines in development of insulin resistance and type 2 diabetes.
- Atherosclerosis and ageing.
- Paraoxonase (PON1) in MCV.
- Oxydative stress and antioxydant system.
- Study of HDL anti-athérogenic's fonctions during ageing.
- Mechanisms of action of the natural antioxidants or the synthesis in the protection of the LDL against lipid oxidation.
- Mechanisms of action of hormones (nuclear receptors).
Cancer of the thyroid and thyroid disorders.
- Obesity (prevention, treatment, organization of health care).
- Metabolic syndrome (molecular mechanisms and treatment).
- Acute respiratory distress syndrome ( SDRA), shock, organic failures, permeability, repair, sepsis, vasopressine, epithelium.
- Evaluation of the experimental and clinical pain.
- Clinical trials on analgesic approaches.
- Study of the endogenous mechanisms of control of the pain to the animal and the human being.
- The role of sex hormones in the pain.
- Placebo effect.
- Regulation of the excitation-contraction coupling in the squeletal muscle.
Head of the department of medicine
Department of medicine, service of endocrinology
- Type 2 diabetes
- Primary dyslipidemia
- Metabolic syndrome
Apneas of the premature baby, the grave illness of the infant and the syndrome of sudden death of the infant.
- Study of the mechanisms of action of new generation of eicosanoids which regulate via a paracrine and autocrine pathway the relaxation and decrease the bronchial inflammation of the bronchial wall of human lungs.
- Analysis of electrophysiological properties of the cellular membranes of the human bronchial wall.
- Analysis of the role of ionic conductances (K + and Cl-) of the surface membrane of the smooth muscles of the respiratory tracts.
- Study of the mode of action of capsazenoids on the non-selective ionic conductances and the Ca2 + sensitivity in the cells of the smooth muscles of respiratory tracts.
- Structure-activity study of the ryanodine receptor, (Ca2 + RELEASE CHANNEL) of the sarcoplasmic reticulum of the diaphragm.
- Involvement of the G protein coupled receptors (RCPG) in the pain.
- Study of the analgesic effects of the RCPG of the neurotensin, the chimiokines and the apelin in preclinical models of pain (Arthritis, Cancer, Neuropathy).
- Circulatory (stroke) and infectious agressions which occur during childhood in the developing brain.
- Immunopathology of perinatal cerebral lesions and development of neuroprotective treatments.
- Impact of the chemical environment on the health of the population and, in particular, the progress of the pregnancy and the development of the child.
- Clinical applications of the liquidic ventilation.